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Fracture healing

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https://www.readbyqxmd.com/read/29149841/establishment-of-rat-ankle-post-traumatic-osteoarthritis-model-induced-by-malleolus-fracture
#1
Dawei Liang, Jian Sun, Fangyuan Wei, Jianzhong Zhang, Pengcui Li, Yingke Xu, Xianwen Shang, Jin Deng, Ting Zhao, Lei Wei
BACKGROUND: Malleolar fracture, which is present in 37-53% of human ankle osteoarthritis (OA), is the most common type of fracture in the ankle joint. In spite of this, no rat animal model has been developed for this type of injury to date. Here, we established a rat ankle post-traumatic OA (PTOA) model induced by malleolar fracture; this model will be useful in ankle OA research. METHODS: Two-month-old male Sprague Dawley (SD) rats were randomized into 2 groups (n = 19 per group): 1) malleolus articular fracture, dislocation, and immediate reduction on the right joints and 2) malleolus articular fracture on the right ankle...
November 17, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29149352/prognostic-potential-of-markers-of-bone-turnover-in-delayed-healing-tibial-diaphyseal-fractures
#2
Malhar Kumar, Dnyaneshwar Shelke, Saumil Shah
INTRODUCTION: Clinical and radiographic examinations detect delayed or nonunion only after the event has occurred. Biochemical markers of bone turnover (BTMs) are promising laboratory tools that offer an early insight into the likelihood of delayed union. We hypothesized that BTMs display temporal variations following fractures and the behavior of BTMs differ between normal and delayed union of fractures. METHODS: This was a prospective study of patients with closed fracture of tibia treated with intramedullary, interlocking nailing...
November 17, 2017: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/29146509/isolated-coronal-shear-fracture-of-the-nonossified-humeral-trochlea-in-a-7-year-old-patient
#3
Michiyo Tomaru, Denju Osada, Kazuya Tamai, Hiroshi Taneichi
Coronal shear fractures of the nonossified humeral trochlea are extremely rare in skeletally immature children. This fracture is difficult to diagnose accurately on routine radiographs. In addition, the mechanism of injury and appropriate treatment methods are unknown. We present the case of a 7-year-old boy who sustained an isolated coronal shear fracture of the nonossified humeral trochlea. Internal fixation of the fracture was performed with 2 K-wires. Two and a half years after surgery, the patient had pain-free active range of motion of the elbow from 0° to 130° with full forearm rotation and magnetic resonance imaging showed healing of the chondral fragment of the trochlea...
November 14, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29146294/distinct-effects-of-interleukin-6-classic-and-trans-signaling-in-bone-fracture-healing
#4
Katja Prystaz, Kathrin Kaiser, Anna Kovtun, Melanie Haffner-Luntzer, Verena Fischer, Anna E Rapp, Astrid Liedert, Gudrun Strauss, Georg H Waetzig, Stefan Rose-John, Anita Ignatius
Bone healing is a complex process with closely linked phases of inflammation, regeneration, and remodeling. Interleukin-6 (IL-6) may crucially regulate this process; however, the underlying mechanisms are presently unclear. IL-6 signals are transmitted via the transmembrane glycoprotein 130 by two distinct mechanisms: classic signaling employing the membrane-anchored IL-6 receptor, and trans-signaling using its soluble form. Here, we investigated the hypothesis that IL-6 classic and trans-signaling have different functions during bone healing...
November 13, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/29145967/bone-intramedullary-reaming-grafts-the-fracture-site-with-cd146-skeletal-progenitors-and-downmodulates-the-inflammatory-environment
#5
Leonardo R Rocha, Rafaela C Sartore, Ana C Leal, Rhayra B Dias, Maria Eugenia L Duarte, João Antônio M Guimarães, Danielle C Bonfim
INTRODUCTION: Femoral shaft fractures generally occur in young adults following a high-energy trauma and are prone to delayed union/non-union. Novel therapies to stimulate bone regeneration will have to mimic some of the aspects of the biology of fracture healing; however, which are these aspects is unclear. Locked intramedullary nailing is the current treatment of choice for the stabilisation of femur shaft fractures, and it is associated with accelerated healing and increased union rates...
October 2017: Injury
https://www.readbyqxmd.com/read/29145966/outcome-evaluation-of-staged-treatment-for-bicondylar-tibial-plateau-fractures
#6
Vincenzo Giordano, Ney Pecegueiro do Amaral, Hilton A Koch, Rodrigo Pires E Albuquerque, Felipe Serrão de Souza, José Félix Dos Santos Neto
BACKGROUND: The universal accepted strategy for treating high-energy tibial plateau fractures remains a topic of ongoing debate. The challenge for the practicing orthopaedic trauma surgeon is to provide anatomical articular fracture reduction, with successfully managing the complex soft-tissue injury that is commonly present at patient admission. The primary aim of the actual study was to evaluate the results of a staged protocol for the treatment of high-energy bicondylar tibial plateau fractures...
October 2017: Injury
https://www.readbyqxmd.com/read/29145316/application-of-ultrasound-guided-c5-nerve-root-block-using-polydeoxyribonucleotide-in-traumatic-c5-nerve-root-injury-caused-by-fracture-of-the-articular-process-of-the-cervical-spine-a-case-report
#7
Donghwi Park
RATIONALE: Cervical nerve root injury is one of the complications of traumatic cervical spine fracture. Although one of the most effective treatments to reduce inflammation in nerve root injuries is the use of corticosteroids or nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids and NSAIDs can inhibit bone healing. So, when nerve injury accompanies bone fractures, corticosteroids and NSAIDs have limitations as therapeutic agents. However, polydeoxyribonucleotide (PDRN) may be useful in the treatment of neuropathy or musculoskeletal pain patients with contraindication of the use of corticosteroids because of its anti-inflammatory effect, as revealed in previous studies...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29144380/a-passive-and-wireless-sensor-for-bone-plate-strain-monitoring
#8
Yisong Tan, Jiale Hu, Limin Ren, Jianhua Zhu, Jiaqi Yang, Di Liu
This paper reports on a sensor for monitoring bone plate strain in real time. The detected bone plate strain could be used for judging the healing state of fractures in patients. The sensor consists of a magnetoelastic material, which can be wirelessly connected and passively embedded. In order to verify the effectiveness of the sensor, a tibia-bone plate-screw (TBS) model was established using the finite element analysis method. A variation of the bone plate strain was obtained via this model. A goat hindquarter tibia was selected as the bone fracture model in the experiment...
November 16, 2017: Sensors
https://www.readbyqxmd.com/read/29143915/effects-of-aging-on-fracture-healing
#9
REVIEW
Dan Clark, Mary Nakamura, Ted Miclau, Ralph Marcucio
PURPOSE OF REVIEW: This review summarizes research on the physiological changes that occur with aging and the resulting effects on fracture healing. RECENT FINDINGS: Aging affects the inflammatory response during fracture healing through senescence of the immune response and increased systemic pro-inflammatory status. Important cells of the inflammatory response, macrophages, T cells, mesenchymal stem cells, have demonstrated intrinsic age-related changes that could impact fracture healing...
November 16, 2017: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/29142870/intracorporeal-reduction-of-condylar-fracture-using-both-pedicled-condylar-and-seperated-ramal-fragments-after-vertical-ramal-osteotomy
#10
Il-Kyu Kim, Jun-Min Jang, Hyun-Young Cho, Ji-Hoon Seo, Dong-Hwan Lee
The aim of this study is to introduce a surgical technique that can maintain blood supply to prevent condylar resorption in the extracorporeal reduction of condylar fracture. Neither the medial pterygoid muscle on the ramal bone nor the lateral pterygoid muscle on the condylar fragment was detached after vertical ramal osteotomy. Thus, reduction was performed in the intracorporeal state. Therefore, blood supply was expected to be maintained to the fragments of both the condylar and ramal bones. On postoperative radiographs, the anatomical outline of the fractured condyle was well restored, and the occlusion was stable...
October 2017: Journal of the Korean Association of Oral and Maxillofacial Surgeons
https://www.readbyqxmd.com/read/29142558/transpedical-interbody-bone-grafting-in-the-treatment-of-senile-osteoporotic-vertebral-fracture
#11
Zhiwei Qin, Hong Liu, Guiying Chen, Guifeng Liu, Peng Zhang, Haitao Zhu
Objective: To evaluate the clinical effect of transpedical interbody bone grafting in the treatment of senile osteoporotic vertebral fracture. Methods: Eighty-six elders with osteoporotic vertebral fracture were selected and divided into a control group and a test group using random double-blind method. Patients in the control group were treated by short-segment transpedicular screw system internal fixation, while patients in the test group were treated by short-segment transpedicular screw system internal fixation in combination with transpedical interbody bone grafting...
September 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29141673/a-customized-fixation-plate-with-novel-structure-designed-by-topological-optimization-for-mandibular-angle-fracture-based-on-finite-element-analysis
#12
Yun-Feng Liu, Ying-Ying Fan, Xian-Feng Jiang, Dale A Baur
BACKGROUND: The purpose of this study was to design a customized fixation plate for mandibular angle fracture using topological optimization based on the biomechanical properties of the two conventional fixation systems, and compare the results of stress, strain and displacement distributions calculated by finite element analysis (FEA). METHODS: A three-dimensional (3D) virtual mandible was reconstructed from CT images with a mimic angle fracture and a 1 mm gap between two bone segments, and then a FEA model, including volume mesh with inhomogeneous bone material properties, three loading conditions and constraints (muscles and condyles), was created to design a customized plate using topological optimization method, then the shape of the plate was referenced from the stress concentrated area on an initial part created from thickened bone surface for optimal calculation, and then the plate was formulated as "V" pattern according to dimensions of standard mini-plate finally...
November 15, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/29137295/clinical-outcome-of-dynamic-hip-locking-plates-and-proximal-femoral-nails-anti-rotation-asia-for-treating-intertrochanteric-femur-fracture-with-lateral-wall-fractures-in-the-elder-patients
#13
Hui Xie, Zhan Wang, Junji Zhang, Langhai Xu, Bao Chen
Purpose: To compare the clinical results of DHLP (Dynamic hip locking plates) and PFNA-IIs (proximal femoral nails anti-rotation-Asia) for treating intertrochanteric femur fracture (IFF) with lateral wall fractures in the elder patients and provide a rationale for the clinical practice. Methods: A retrospective analysis of 43 patients of IFF with lateral wall fractures was performed from December 2009 to April 2015. Intraoperative variables and postoperative complications and function were compared between the two groups...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29133966/effect-of-low-level-laser-therapy-on-fracture-healing-in-rabbits
#14
Fahimeh Kamali Sarvestani, Nasrin Salehi Dehno, Seifollah Dehghani Nazhvani, Mohammad Hadi Bagheri, Soheila Abbasi, Yasaman Khademolhosseini, Elham Gorji
Background and aims: The purpose of this study was to investigate the effect of low-level laser therapy (LLLT) on radial bone fracture gap healing in a rabbit model. Materials Subjects and Methods: Thirty male white New Zealand rabbits under general anesthesia had a 3mm slice of radial bone surgically removed. Fifteen rabbits were treated by 830 nm laser at 4 J/cm(2) and 15 were used as non-treated controls. Callus development was assessed by X-ray and radiographs every 7 days for 3 weeks...
September 30, 2017: Laser Therapy
https://www.readbyqxmd.com/read/29133198/study-of-the-mechanical-reliability-of-an-s-shaped-adjustable-osteosynthesis-plate-for-bilateral-sagittal-split-osteotomies-study-on-15-consecutive-cases
#15
Alexis Veyssiere, Nicols Leprovost, Béatrice Ambroise, Raphaelle Prévost, Anne Chatellier, Hervé Bénateau
INTRODUCTION: The main challenge during the osteosynthesis of a bilateral sagittal split osteotomy (BSSO) is to take into account the correct position of the condyle. Adjustable plates can be used to fine-tune the final occlusion without changing the osteosynthesis. A new type of adjustable plate is presented in this article. The aim is to assess the mechanical reliability of this system during the surgery and during the healing period, thanks to a preliminary prospective on 15 consecutive cases...
November 10, 2017: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29130655/-efficacy-of-sacroiliac-joint-anterior-approach-with-double-reconstruction-plate-and-computer-assisted-navigation-percutaneous-sacroiliac-screw-for-treating-tile-c1-pelvic-fractures
#16
Zhen Tan, Yue Fang, Hui Zhang, Lei Liu, Zhou Xiang, Gang Zhong, Fu-Guo Huang, Guang-Lin Wang
OBJECTIVE: To compare the efficacy of sacroiliac joint anterior approach with double reconstruction plate and computer assisted navigation percutaneous sacroiliac screw for treating Tile C1 pelvic fractures. METHODS: Fifty patients with pelvic Tile C1 fractures were randomly divided into two groups ( n=25 for each) in the orthopedic department of West China Hospital of Sichuan University from December 2012 to November 2014. Patients in group A were treated by sacroiliac joint dislocation with anterior plate fixation...
September 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/29130654/-classification-and-treatment-of-sacroiliac-joint-dislocation
#17
Zhen Tan, Zhong Huang, Liang Li, Wei-Kun Meng, Lei Liu, Hui Zhang, Guang-Lin Wang, Fu-Guo Huang
OBJECTIVE: To develop a renewed classification and treatment regimen for sacroiliac joint dislocation. METHODS: According to the direction of dislocation of sacroiliac joint,combined iliac,sacral fractures,and fracture morphology,sacroiliac joint dislocation was classified into 4 types. Type Ⅰ (sacroiliac anterior dislocation): main fracture fragments of posterior iliac wing dislocated in front of sacroiliac joint. Type Ⅱ (sacroiliac posterior dislocation): main fracture fragments of posterior iliac wing dislocated in posterior of sacroiliac joint...
September 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/29129131/increased-wound-complication-with-intramedullary-screw-fixation-of-clavicle-fractures-is-it-thermal-necrosis
#18
Peter Domos, Graham Tytherleigh-Strong, Lee Van Rensburg
PURPOSE: Adult mid-shaft clavicle fractures are common injuries. For displaced fractures, open reduction with plate or intramedullary (IM) fixation is the widely used techniques. All methods have their own potential drawbacks, especially related to local soft tissue complications. There is little information about outcome and management of local wound complications after clavicle fracture fixations. METHODS: Ninety-seven patients underwent open reduction and internal fixation, 17 were treated with IM screw fixation and 80 with plate fixation...
September 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/29127918/management-of-type-iib-and-iiib-olecranon-fractures-case-series
#19
Mohammed Ali, Catherine Hatzantonis, Dimitrios Aspros, Nirad Joshi, D I Clark, Amol Tambe
OBJECTIVES: to report and evaluate the functional outcome of plate fixation in comminuted olecranon fractures (Mayo types IIB and IIIB). METHOD: 23 consecutive patients with comminuted fractures of the olecranon presenting to our unit Between Feb 2011 and Jan 2015, at a mean follow-up of thirty-six months. Main outcome measurements include radiographic healing, post-operative range of motion, complications, outcome score and patient satisfaction. RESULTS: Our study included thirteen females and ten males with a mean age of 55(18-97)...
November 6, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29125707/vascularized-humeral-periosteal-flap-to-treat-lateral-humeral-condyle-nonunion-an-anatomical-study-and-report-of-two-successfully-treated-pediatric-cases
#20
S Sergi Barrera-Ochoa, Francisco Soldado, Alfonso Rodriguez-Baeza, Paula Diaz-Gallardo, Felipe Hodgson, Pablo S Corona, Jorge Knörr
PURPOSE: Nonunion is a common complication of lateral condyle humeral (LCH) fractures in children. In situ fixation with a screw and bone grafting is the classically-recommended method of treatment. The purpose of this study is to analyze the feasibility of obtaining a vascularized periosteal flap obtained from the lateral humerus and based on the posterior collateral radial vessels (PCRV). Second, to report the results after the application in two pediatric cases. METHODS: Periosteal branches of PCRV were studied in ten upper limbs from fresh human cadavers...
November 10, 2017: Microsurgery
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