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https://www.readbyqxmd.com/read/29354870/knowledge-and-practice-of-oral-cancer-screening-in-teaching-faculty-comparison-of-specialty-and-year-of-clinical-experience
#1
Shintaro Kogi, John DaSilva, Yusuke Mikasa, Cliff Lee, Shigemi Ishikawa-Nagai, Qian Yang, Hidemichi Kihara, Ryosuke Abe, Hiroyuki Yamada
The purpose of this study was to assess the knowledge, practice, confidence, and perceived barriers to oral cancer screening among teaching faculty in Japan. Results were compared by specialist as well as years of clinical experience. A 25-question survey was used to assess the oral cancer screening practices of faculty dentists at Iwate Medical University, School of Dental Medicine, the only dental school located in the northeast (Tohoku) region of Japan. The study was approved by the Institutional Review Board of Iwate Medical University...
January 21, 2018: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/29336342/-homogeneity-of-the-european-training-program-the-role-of-the-european-board-of-urology
#2
José Luís Domínguez Escrig
From its origins and acting through its specific committees, the E.B.U. has been dedicated to the improvement and standardization of urological training across Europe. Identifying minimal requirements for urology training, publishing a European Curriculum and defining basic rules for accreditation of educational activities, hence, offering a systematic assessment for the recognition of quality. Working through different dedicated committees, the E.B.U. oversees every aspect on the urological training in Europe...
January 2018: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/29318957/research-brief-self-reports-of-a-constellation-of-persistent-antiandrogenic-estrogenic-physical-and-psychological-effects-of-finasteride-usage-among-men
#3
Alicia A Walf, Shan Kaurejo, Cheryl A Frye
Our research objective is to understand more, through subjective, self-reports on discussion boards/forums, persons' experiences associated with the use of drugs that alter androgen metabolism, such as finasteride. Finasteride is an orally active, specific inhibitor of 5α-reductase, which is localized to many androgen-dependent tissues. Finasteride inhibits the conversion of testosterone (T) to dihydrotestosterone (DHT), and is commonly used to treat benign prostatic hypertrophy (BPH) and male pattern baldness (MPB), both disorders associated with elevated DHT levels and 5α-reductase activity in the prostate and hair follicles, respectively...
January 1, 2018: American Journal of Men's Health
https://www.readbyqxmd.com/read/29303871/a-systematic-evaluation-of-state-laws-governing-optometric-glaucoma-management-in-the-united-states-up-to-2015
#4
Kevin Chodnicki, Sachin Kalarn, Laura Quinn, Henry Jampel, Osamah Saeedi
PURPOSE: To describe state laws that govern the optometric practice of glaucoma management in the United States and to correlate those laws with state demographics up to 2015. MATERIALS AND METHODS: We performed a cross-sectional ecological study of the 50 United States and the District of Columbia. Regulations governing optometric scope of practice as written by each state Board of Optometry were reviewed. Specific optometric privileges assessed included: ability to manage glaucoma independently, use of diagnostic pharmaceutical agents, use of therapeutic pharmaceutical agents (including topical and oral steroids and other oral pharmaceutical agents), intravenous injections, intraocular injections, therapeutic lasers, presence of defined referral and co-management guidelines, and hours of yearly continuing education needed for glaucoma management...
January 4, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29301050/field-detection-of-drugs-of-abuse-in-oral-fluid-using-the-alere%C3%A2-dds%C3%A2-2-mobile-test-system-with-confirmation-by-liquid-chromatography-tandem-mass-spectrometry-lc-ms-ms
#5
Alex J Krotulski, Amanda L A Mohr, Melissa Friscia, Barry K Logan
The collection and analysis of drugs in oral fluid (OF) at the roadside has become more feasible with the introduction of portable testing devices such as the Alere™ DDS®2 Mobile Test System (DDS®2). The objective of this study was to compare the on-site results for the DDS®2 to laboratory-based confirmatory assays with respect to detection of drugs of abuse in human subjects. As part of a larger Institutional Review Board approved study, two OF samples were collected from each participant at a music festival in Miami, FL, USA...
December 28, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/29299507/outpatient-management-of-cholesteatoma-with-canal-wall-reconstruction-tympanomastoidectomy
#6
Richard Kao, Todd Wannemuehler, Charles W Yates, Rick F Nelson
Objectives: The postoperative wound infection rate for canal wall reconstruction (CWR) tympanomastoidectomy with mastoid obliteration in the treatment of chronic otitis media with cholesteatoma has been reported to be 3.6%. Postoperative administration of 24-48 hours of intravenous antibiotics has been recommended. We aim to determine the infection rate of CWR with postoperative outpatient oral antibiotics. Study Design: Institutional review board-approved retrospective case review...
December 2017: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/29295762/from-nature-to-creation-going-around-in-circles-the-art-of-peptide-cyclization
#7
REVIEW
Rui-Yang Zhang, Parashar Thapa, Michael J Espiritu, Vinay Menon, Jon-Paul Bingham
Cyclic peptides and cyclotides are becoming common identities within the present efforts seen in peptide engineering - as we seek approaches to achieve potent biological activity, pharmacological selectivity, structurally stability and oral bioavailability. Yet this unique family of peptides has faced uncommon hurdles in their discovery, synthesis and bioengineering, retaining to characteristics that truly deviate these from their linear counterparts. In this mini-review we take a board spectrum approach to introduce this novel family of biomolecules and the troubles that they face in their sequence and disulfide connectivity assignment, together highlighting the present combined strategies involved in cyclic peptide/cyclotide synthesis and modification...
December 14, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29279828/rare-finding-of-eustachian-tube-calcifications-with-cone-beam-computed-tomography
#8
Ali Z Syed, Anna Hawkins, Leela Subashini Alluri, Buthainah Jadallah, Kiran Shahid, Michael Landers, Hussein M Assaf
Soft tissue calcification is a pathological condition in which calcium and phosphate salts are deposited in the soft tissue organic matrix. This study presents an unusual calcification noted in the cartilaginous portion of the Eustachian tube. A 67-year-old woman presented for dental treatment, specifically for implant placement, and cone-beam computed tomography (CBCT) was performed. The CBCT scan was reviewed by a board-certified oral and maxillofacial radiologist and revealed incidental findings of 2 distinct calcifications in the cartilaginous portion of the Eustachian tube...
December 2017: Imaging Science in Dentistry
https://www.readbyqxmd.com/read/29279063/evaluating-satisfaction-of-patients-with-hereditary-angioedema-with-their-past-and-present-treatments-implications-for-future-therapies
#9
Jaison Jose, Erik B Lehman, Timothy Craig
BACKGROUND: Ever-expanding armamentarium of treatments for hereditary angioedema (HAE) are associated with various adverse effects, issues with vascular access, or lack of self-administration. OBJECTIVE: To understand patients' impressions and confidence in their past and present treatments, and identifying adverse events while also directly asking patients to reveal their hope for the future of HAE management and treatments. METHODS: After institutional review board approval, all subjects with laboratory-confirmed HAE were mailed a survey that they completed and returned to the researchers, and data were collected and entered into a secure online web application for surveys...
January 1, 2018: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/29251544/consensus-recommendations-for-managing-osteoarthritic-pain-with-topical-nsaids-in-asia-pacific
#10
Bonifacio S Rafanan, Benedict F Valdecañas, Boon Ping Lim, Anan Malairungsakul, Warat Tassanawipas, Chen Shiyi, Lung Fung Tse, Tuan Khanh Luong
Osteoarthritis prevalence is expected to increase markedly in the Asia-Pacific region due to rapid population aging. Identifying effective and safe therapeutic options to manage osteoarthritic pain is viewed as a priority. The Asia-Pacific Experts on Topical Analgesics Advisory Board developed consensus statements for use of topical NSAIDs in musculoskeletal pain. Evidence supporting these statements in osteoarthritic pain was reviewed. Best available evidence indicates that topical NSAIDs have a moderate effect on relief of osteoarthritic pain, comparable to that of oral NSAIDs but with a better risk-to-benefit ratio...
December 18, 2017: Pain Management
https://www.readbyqxmd.com/read/29248859/impact-of-age-comorbidity-and-polypharmacy-on-the-efficacy-and-safety-of-edoxaban-for-the-treatment-of-venous-thromboembolism-an-analysis-of-the-randomized-double-blind-hokusai-vte-trial
#11
Thomas Vanassche, Peter Verhamme, Philip S Wells, Annelise Segers, Walter Ageno, Marjolein P A Brekelmans, Cathy Z Chen, Alexander T Cohen, Michael A Grosso, Andria P Medina, Michele F Mercuri, Shannon M Winters, George Zhang, Jeffrey I Weitz, Gary E Raskob, Harry R Büller
BACKGROUND: Many patients with venous thromboembolism (VTE) are elderly, have multiple comorbidities and take several concomitant medications. Physicians may prefer warfarin over direct oral anticoagulants (DOACs) in such patients because comparative data are lacking. This analysis was designed to determine the effects of advanced age, comorbidities, and polypharmacy on the efficacy and safety of edoxaban and warfarin in patients with VTE. METHODS: Using data from the Hokusai-VTE study, we report rates of recurrent VTE and of clinically relevant bleeding by age category (<65, 65-75, and ≥75; <80 versus ≥80years), and by number of comorbidities (0, 1-2, >2) and concomitant medications (<3, 3-5, >5)...
December 13, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/29247621/peripheral-ameloblastoma-a-study-of-18-cases-and-usage-of-ber-ep4-immunohistochemistry-to-rule-out-a-diagnosis-of-intraoral-basal-cell-carcinoma
#12
Jasbir D Upadhyaya, Indraneel Bhattacharyya, Sarah G Fitzpatrick, Donald M Cohen, Mohammed N Islam
PURPOSE: Peripheral ameloblastoma (PA) is a rare odontogenic tumor arising in the mucosa of tooth-bearing areas of the jaws that typically shows no radiographic evidence of bone involvement. It bears close histologic resemblance to intraoral basal cell carcinoma (IOBCC), an extremely rare entity. In our experience from previous published data, 3 cases of IOBCC were initially misdiagnosed as PA and were later differentiated from PA on the basis of Ber-EP4 protein expression. This unusual but significant experience set the premise for us to rule out a diagnosis of IOBCC by evaluating Ber-EP4 expression in all previously diagnosed cases of PA from the University of Florida Oral Pathology (UFOP) biopsy service archives...
November 23, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29234384/screening-of-natural-bioactive-metabolites-and-investigation-of-antioxidant-antimicrobial-antihyperglycemic-neuropharmacological-and-cytotoxicity-potentials-of-litsea-polyantha-juss-ethanolic-root-extract
#13
Nripendra Nath Biswas, Amit Kumar Acharzo, Shams Anamika, Shamsunnahar Khushi, Bishwajit Bokshi
This study was designed to identify some bioactive phytochemicals from ethanolic extract of roots of Litsea polyantha and to evaluate some of its pharmacological activities. Phytochemical tests indicated the presence of reducing sugar, combined reducing sugar, tannins, flavonoids, alkaloids, terpenoids, and phenol. In the antioxidant assay using 2-diphenyl-1-picryl-hydrazyl (DPPH) free radical scavenging method, the IC50 value was found to be 82.31 μg/mL. Total content of phenolic compounds, flavonoid, and tannin was found to be 152...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29174128/intrauterine-insemination-with-ovarian-stimulation-versus-expectant-management-for-unexplained-infertility-tui-a-pragmatic-open-label-randomised-controlled-two-centre-trial
#14
Cynthia M Farquhar, Emily Liu, Sarah Armstrong, Nicola Arroll, Sarah Lensen, Julie Brown
BACKGROUND: Women with unexplained infertility are often offered intrauterine insemination (IUI) with ovarian stimulation as an alternative to in-vitro fertilisation (IVF). However, little evidence exists that IUI is an effective treatment. In 2013, the UK National Institute for Health and Care Excellence recommended that IUI should not be routinely offered for couples with unexplained infertility. METHODS: For this pragmatic, open-label, randomised, controlled, two-centre study, we enrolled women attending two fertility clinics in New Zealand with unexplained infertility and an unfavourable prognosis of natural conception...
November 23, 2017: Lancet
https://www.readbyqxmd.com/read/29166935/phytochemical-and-pharmacological-evaluation-of-ethanolic-extract-of-lepisanthes-rubiginosa-l-leaves
#15
Md Mahedi Hasan, Amir Hossain, Abdullah Shamim, Md Mustafizur Rahman
BACKGROUND: The current study was conducted to evaluate the antioxidant, analgesic, antihyperglycemic, neuropharmacological and antidiarrheal activities of ethanolic extract of Lepisanthes rubiginosa L. leaves in different experimental models. METHODS: Quantitative and qualitative analysis were done by TLC (thin layer chromatography) and DPPH (1,1-diphenyl-2-picrylhydrazyl) free radical scavenging assay. Analgesic, antihyperglycemic and antidiarrheal activities were evaluated using acetic acid induced writhing in mice, oral glucose tolerance test and castor oil induced diarrhea, respectively...
November 22, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29146647/initial-non-operative-management-of-uncomplicated-appendicitis-in-children-a-protocol-for-a-multicentre-randomised-controlled-trial-apac-trial
#16
Max Knaapen, Johanna H van der Lee, Roel Bakx, Sarah-May L The, Ernst W E van Heurn, Hugo A Heij, Ramon R Gorter
INTRODUCTION: Based on epidemiological, immunological and pathology data, the idea that appendicitis is not necessarily a progressive disease is gaining ground. Two types are distinguished: simple and complicated appendicitis. Non-operative treatment (NOT) of children with simple appendicitis has been investigated in several small studies. So far, it is deemed safe. However, its effectiveness and effect on quality of life (QoL) have yet to be established in an adequately powered randomised trial...
November 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/29128151/is-the-choosing-wisely-%C3%A2-campaign-model-applicable-to-the-management-of-multiple-sclerosis-in-france-a-gresep-pilot-study
#17
B Trumbic, H Zéphir, J-C Ouallet, E Le Page, D Laplaud, C Bensa, J de Sèze
BACKGROUND: Launched in the US in 2012, Choosing Wisely(®) is a campaign promoted by the American Board of Internal Medicine (ABIM) Foundation with the goal of improving healthcare effectiveness by avoiding wasteful or unnecessary medical tests, treatments and procedures. It uses concise recommendations produced by national medical societies to start discussions between physicians and patients on the relevance of these services as part of a shared decision-making process. The Multiple Sclerosis Focus Group (Groupe de Reflexion Autour de la Sclérose en Plaques; GRESEP) undertook a pilot study to assess the relevance and feasibility of this approach in the management of multiple sclerosis (MS) in France...
November 8, 2017: Revue Neurologique
https://www.readbyqxmd.com/read/29103736/the-impact-of-intraoperative-opioid-use-on-survival-after-oral-cancer-surgery
#18
Miguel A Patino, Rafael E Ramirez, Carlos A Perez, Lei Feng, Pranav Kataria, Jeffrey Myers, Juan P Cata
OBJECTIVES: To investigate the impact of opioid use on cancer recurrence after oral cancer surgery. We hypothesized that the amount of opioids administered during oral cancer surgery is an independent predictor of recurrence free survival (RFS) and overall survival (OS). METHODS: After Institutional Review Board approval, we collected demographic, tumor related, intraoperative and survival data of patients who had oral cancer surgery. Multivariable Cox proportional hazards models were used to determine the impact of important covariates on RFS and OS...
November 2017: Oral Oncology
https://www.readbyqxmd.com/read/29101128/oral-chinese-herbal-medicine-for-psoriasis-vulgaris-protocol-for-a-randomised-double-blind-double-dummy-multicentre-clinical-trial
#19
Jingwen Deng, Danni Yao, Chuanjian Lu, Zehuai Wen, Yuhong Yan, Ziyang He, Huimei Wu, Hao Deng
INTRODUCTION: Psoriasis vulgaris is a common skin disease that is characterised by persistent localised erythematous scaly plaques. Yinxieling is a Chinese herbal formula for psoriasis that has been used for more than 20 years in China. To facilitate application, PSORI-CM01 was developed based on the optimisation and simplification of Yinxieling tablets performed in a previous study and in clinical practice. However, the scientific evidence regarding whether PSORI-CM01 is more effective for psoriasis than the original Yinxieling remains insufficient...
November 3, 2017: BMJ Open
https://www.readbyqxmd.com/read/29058370/proton-therapy-for-pediatric-head-and-neck-malignancies
#20
Jennifer Vogel, Stefan Both, Maura Kirk, Hann-Hsiang Chao, Rochelle Bagatell, Yimei Li, Richard Womer, Naomi Balamuth, Anne Reilly, Goldie Kurtz, Robert Lustig, Zelig Tochner, Christine Hill-Kayser
PURPOSE: Pediatric head and neck malignancies are managed with intensive multimodality therapy. Proton beam therapy (PBT) may reduce toxicity by limiting exposure of normal tissue to radiation. In this study, we report acute toxicities and early outcomes following PBT for pediatric head and neck malignancies. MATERIALS AND METHODS: Between 2010 and 2016, pediatric patients with nonhematologic malignancies of the head and neck were treated with PBT. Clinical and dosimetric data were abstracted from the medical record and treatment planning system with institutional review board approval...
October 23, 2017: Pediatric Blood & Cancer
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