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https://www.readbyqxmd.com/read/28710224/assessing-the-effectiveness-of-a-3-month-day-and-night-home-closed-loop-control-combined-with-pump-suspend-feature-compared-with-sensor-augmented-pump-therapy-in-youths-and-adults-with-suboptimally-controlled-type-1-diabetes-a-randomised-parallel-study-protocol
#1
Lia Bally, Hood Thabit, Martin Tauschmann, Janet M Allen, Sara Hartnell, Malgorzata E Wilinska, Jane Exall, Viki Huegel, Judy Sibayan, Sarah Borgman, Peiyao Cheng, Maxine Blackburn, Julia Lawton, Daniela Elleri, Lalantha Leelarathna, Carlo L Acerini, Fiona Campbell, Viral N Shah, Amy Criego, Mark L Evans, David B Dunger, Craig Kollman, Richard M Bergenstal, Roman Hovorka
INTRODUCTION: Despite therapeutic advances, many individuals with type 1 diabetes are unable to achieve tight glycaemic target without increasing the risk of hypoglycaemia. The objective of this study is to determine the effectiveness of a 3-month day-and-night home closed-loop glucose control combined with a pump suspend feature, compared with sensor-augmented insulin pump therapy in youths and adults with suboptimally controlled type 1 diabetes. METHODS AND ANALYSIS: The study adopts an open-label, multi-centre, multi-national (UK and USA), randomised, single-period, parallel design and aims for 84 randomised patients...
July 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/28703178/an-investigation-into-the-variability-of-primary-care-oral-surgery-contracts-and-tariffs-in-england-and-wales-2014-2015
#2
R J Hierons, G Gerrard, R Jones
Primary care oral surgery services vary markedly throughout the country but until now there has been a paucity of data on these services. The British Association of Oral Surgeons (BAOS) primary care group (the authors) were tasked to gather data around primary care oral surgery contracts and tariffs and provide evidence-based recommendations on the commissioning of these services. Following a freedom of information (FOI) request, data were obtained for 27 English local area teams and seven Welsh local health boards...
June 9, 2017: British Dental Journal
https://www.readbyqxmd.com/read/28694536/orbital-fractures-treated-in-auckland-from-2010-2015-review-of-patient-outcomes
#3
Lanit Anand, Christopher Sealey
AIM: The purpose of this study was to review patient outcomes from surgical reconstruction of isolated orbital fractures, performed by the Auckland District Health Board (ADHB) Oral and Maxillofacial Surgery service (OMFS), from 2010 to 2015. In particular, we wished to assess titanium as an orbital reconstructive material and compare outcomes with the international literature. METHOD: Hospital records for 103 adults (>18 years old) who underwent repair of isolated orbital fractures by the OMFS department at Middlemore Hospital, between 2010 and 2015, were reviewed...
July 7, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/28685865/development-and-evaluation-of-online-education-to-increase-the-forensic-relevance-of-oral-health-records
#4
Lauren Stow, Denice Higgins
BACKGROUND: Human identification can be reliably established by dental comparison; success is significantly impacted by inadequate antemortem information. Previous Australian research revealed suboptimal recording of features important for forensic dental identification and compliance with Dental Board of Australia guidelines. We hence created and evaluated an online education programme aimed at improving oral health practitioner recording. METHODS: An Interactive Learning Module (ILM) was constructed and released to three focus groups representing practitioners with varying experience levels - Australian Society of Forensic Odontology members, third year dental students and the wider dental community...
July 7, 2017: Australian Dental Journal
https://www.readbyqxmd.com/read/28678855/does-a-presentation-s-medium-affect-its-message-powerpoint-prezi-and-oral-presentations
#5
Samuel T Moulton, Selen Türkay, Stephen M Kosslyn
Despite the prevalence of PowerPoint in professional and educational presentations, surprisingly little is known about how effective such presentations are. All else being equal, are PowerPoint presentations better than purely oral presentations or those that use alternative software tools? To address this question we recreated a real-world business scenario in which individuals presented to a corporate board. Participants (playing the role of the presenter) were randomly assigned to create PowerPoint, Prezi, or oral presentations, and then actually delivered the presentation live to other participants (playing the role of corporate executives)...
2017: PloS One
https://www.readbyqxmd.com/read/28658595/flexor-digitorum-superficialis-tenodesis-for-traumatic-digit-amputation-at-the-level-of-the-proximal-phalanx
#6
Maureen A O'Shaughnessy, Sanjeev Kakar
BACKGROUND: Traumatic amputation of the digit requiring revision amputation at the level of the proximal phalanx provides the opportunity to improve flexor function via tenodesis of the remaining flexor digitorum superficialis (FDS) tendon. Salvage of the remaining FDS and performing flexor tenodesis to the proximal phalanx allows increased flexion at the metacarpophalangeal (MCP) joint. METHODS: This series reviews FDS tenodesis, outlining its surgical technique with clinical and functional outcomes...
June 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28650253/diagnosis-and-treatment-of-osteoporosis-before-and-after-fracture-a-side-by-side-analysis-of-commercially-insured-and-medicare-advantage-osteoporosis-patients
#7
Jessica Weaver, Shiva Sajjan, E Michael Lewiecki, Steven T Harris
BACKGROUND: Although treatment for osteoporosis is recommended by U.S. clinical guidelines, a lack of diagnosis and treatment is common among patients with osteoporotic fractures. OBJECTIVE: To determine the rates of osteoporosis diagnosis and treatment before and after various types of fractures. METHODS: This was a retrospective claims analysis using data from the Humana Medicare Advantage claims (Medicare group) and Optum Insight Clinformatics Data Mart commercial claims (Commercial group)...
July 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28646558/neurology-concepts-young-women-and-ischemic-stroke-evaluation-and-management-in-the-emergency-department
#8
Bernard P Chang, Charles Wira, Joseph Miller, Murtaza Akhter, Bradley E Barth, Joshua Willey, Lauren Nentwich, Tracy Madsen
OBJECTIVE: Ischemic stroke is a leading cause of morbidity and mortality worldwide. While the incidence of ischemic stroke is highest in older populations, incidence of ischemic stroke in adults has been rising particularly rapidly among young (e.g. premenopausal) women. The evaluation and timely diagnosis of ischemic stroke in young women presents a challenging situation in the emergency department, due to a range of sex-specific risk factors and to broad differentials. The goals of this concepts paper are to summarize existing knowledge regarding the evaluation and management of young women with ischemic stroke in the acute setting...
June 24, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/28644942/total-wrist-arthroplasty-versus-wrist-fusion-utilization-and-complication-rates-as-reported-by-abos-part-ii-candidates
#9
Richard M Hinds, John T Capo, Marco Rizzo, James R Roberson, Michael B Gottschalk
BACKGROUND: The aim of this study was to assess national trends in the utilization and complication rates of total wrist arthroplasty (TWA) and total wrist fusion (WF) as identified via review of the American Board of Orthopedic Surgery (ABOS) Part II candidate database. METHODS: The ABOS Part II candidate database is a collection of cases reported by candidates of the ABOS Part II board certification oral exam. The ABOS database was queried for all TWA and WF cases performed from 2005 to 2014...
July 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28632531/a-descriptive-survey-of-anesthesiology-residency-simulation-programs-how-are-programs-preparing-residents-for-the-new-american-board-of-anesthesiology-applied-certification-examination
#10
Robert S Isaak, Fei Chen, Harendra Arora, Susan M Martinelli, David A Zvara, Marjorie P Stiegler
BACKGROUND: Anesthesiology residency programs may need new simulation-based programs to prepare residents for the new Objective Structured Clinical Examination (OSCE) component of the American Board of Anesthesiology (ABA) Primary Certification process. The design of such programs may require significant resources, including faculty time, expertise, and funding, as are currently needed for structured oral examination (SOE) preparation. This survey analyzed the current state of US-based anesthesiology residency programs regarding simulation-based educational programming for SOE and OSCE preparation...
June 19, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28623686/temporomandibular-prosthetic-joint-infections-associated-with-propionibacterium-acnes-a-case-series-and-a-review-of-the-literature
#11
Ruba Khader, Joseph Tingey, Steven Sewall
PURPOSE: The orthopedic literature has shown an increasing incidence of prosthetic joint infections (PJIs) associated with Propionibacterium acnes (P acnes). These infections present serious diagnostic and management challenges to the treating surgeons. In this review, the authors report on cases of P acnes-related temporomandibular joint (TMJ) PJIs that have been diagnosed and treated at their institution. MATERIALS AND METHODS: After approval by the institutional review board, information was obtained through a retrospective chart review...
May 24, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28619391/pharmacists-attitudes-regarding-provision-of-sexual-and-reproductive-health-services
#12
Austin T Hilverding, Natalie A DiPietro Mager
OBJECTIVES: The primary objective was to assess attitudes from Ohio pharmacists about contraceptive authority. Secondary objectives included determining pharmacists' perceptions of benefits, barriers, and preparedness for offering such services and examining attitudes about and experiences with other reproductive health topics to inform future research. METHODS: An anonymous 26-question Institutional Review Board-approved electronic survey was developed and distributed via Qualtrics to a random sample of 500 licensed pharmacists in Ohio...
June 12, 2017: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/28573839/what-proportion-of-caries-into-dentine-at-age-5-is-present-at-age-3
#13
N Monaghan, M Morgan
OBJECTIVE: To explore the proportion of decay at age 5 in Wales presenting by and after age 3 years from geographical and deprivation perspectives. BASIC RESEARCH DESIGN: Retrospective analysis of data from independent cross-sectional studies of 3-year-olds in early 2013 and 5-year-olds in school year 2014/5. This includes novel graphical presentation of caries at age 3 and estimated 3-5 caries increment at age 5. SETTING AND PARTICIPANTS: NHS oral health surveillance programme in Wales examining children in nurseries at age 3 and in schools two years later...
June 2017: Community Dental Health
https://www.readbyqxmd.com/read/28573836/improving-care-for-bariatric-dental-patients-in-north-wales
#14
P Dowey
This paper presents the experiences of Betsi Cadwaladr University Health Board, North Wales, UK in improving facilities, access and quality of care for bariatric dental patients. It includes the multi-stakeholder audit of existing practice which informed those improvements. Public health competencies illustrated: needs assessment; development and implementation of oral health strategies; oral health improvement; development of clinical pathways; improving patient safety; clinical and public engagement; addressing inequalities...
June 2017: Community Dental Health
https://www.readbyqxmd.com/read/28565759/oral-administration-of-ampelopsin-protects-against-acute-brain-injury-in-rats-following-focal-cerebral-ischemia
#15
Xiao-Li Ye, Ling-Qun Lu, Wei Li, Qi Lou, Hong-Gang Guo, Qiao-Juan Shi
Ampelopsin (AMP) is isolated from the Chinese medicinal herb Ampelopsis grossedentata (Hand-Mazz) and has been associated with numerous biological and pharmacological activities. However, it is not clear whether AMP has a direct protective effect on cerebral ischemia reperfusion injury. Therefore, the present study investigated its role in acute brain injury following focal cerebral ischemia in rats. The current study induced transient focal cerebral ischemia by performing middle cerebral artery occlusion (MCAO) for 60 min, followed by 24 h of reperfusion...
May 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28564613/high-dose-tetrabromobisphenol-a-impairs-hippocampal-neurogenesis-and-memory-retention
#16
Ah Hyun Kim, Hye Jeong Chun, Seulah Lee, Hyung Sik Kim, Jaewon Lee
Tetrabromobisphenol A (TBBPA) is a brominated flame retardant that is commonly used in commercial and household products, such as, computers, televisions, mobile phones, and electronic boards. TBBPA can accumulate in human body fluids, and it has been reported that TBBPA possesses endocrine disruptive activity. However, the neurotoxic effect of TBBPA on hippocampal neurogenesis has not yet been investigated. Accordingly, the present study was undertaken to evaluate the effect of TBBPA on adult hippocampal neurogenesis and cognitive function...
May 28, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28557753/oral-corticosteroid-prescribing-for-children-with-asthma-in-a-medicaid-managed-care-program
#17
Harold J Farber, Edwin A Silveira, Douglas R Vicere, Viral D Kothari, Angelo P Giardino
BACKGROUND AND OBJECTIVE: Short courses of oral corticosteroid (OCS) medication are recommended for treatment of moderate to severe asthma exacerbations. Concern has been raised about OCS overuse. Our objective is to describe rates of OCS dispensing among children with asthma and factors associated with variation in OCS dispensing. METHODS: Claims data for children 1 to <18 years of age with an asthma diagnosis between January 2011 and January 2016 were extracted from the computerized databases of Texas Children's Health Plan...
May 2017: Pediatrics
https://www.readbyqxmd.com/read/28529196/the-usage-of-mock-oral-examinations-for-program-improvement
#18
Shari L Meyerson, Stuart Lipnick, Edward Hollinger
OBJECTIVE: Mock oral examinations are often used to prepare residents for the American Board of Surgery certifying examination. Another potential use of these examinations is to identify programmatic weaknesses. Results from a multi-institutional mock oral examination were evaluated to determine if specific areas of weakness within each of the participating programs could be identified to facilitate program development. DESIGN: A mock oral examination was administered annually consisting of 3 examination rooms per resident with 3 cases in each room...
May 18, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28501522/long-term-effects-of-flosequinan-on-the-morbidity-and-mortality-of-patients-with-severe-chronic-heart-failure-primary-results-of-the-profile-trial-after-24-years
#19
Milton Packer, Bertram Pitt, Jean-Lucien Rouleau, Karl Swedberg, David L DeMets, Lloyd Fisher
OBJECTIVES: The objective of this clinical trial was to evaluate the long-term effects of flosequinan on the morbidity and mortality of patients with severe chronic heart failure. BACKGROUND: Flosequinan was the first oral vasodilator to be used in the clinic to augment the effects of digitalis, diuretics, and angiotensin-converting enzyme inhibitors in heart failure. However, the drug activated neurohormonal systems and exerted both positive inotropic and chronotropic effects, raising concerns about its safety during long-term use...
May 2, 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/28485529/exosomes-mediate-interepithelial-transfer-of-functional-p-glycoprotein-in-chronic-rhinosinusitis-with-nasal-polyps
#20
Angela L Nocera, Marcel M Miyake, Philip Seifert, Xue Han, Benjamin S Bleier
OBJECTIVE: P-glycoprotein (P-gp) drives type-2 helper T-cell inflammation in chronic rhinosinusitis with nasal polyps (CRSwNP) through unknown posttranslational mechanisms of overexpression. A recent randomized clinical trial demonstrated that inhibition of P-gp was as effective as oral steroids and biologics in treating CRSwNP. Exosomes are 30- to 150-nm vesicles capable of intercellular membrane protein transfer. The aims of this study were 1) to determine whether CRSwNP mucus exosomes are enriched with P-gp, and 2) whether exosomal P-gp can be functionally transferred to autologous epithelial cells as a putative mechanism for the proinflammatory overexpression of P-gp in CRSwNP...
May 9, 2017: Laryngoscope
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