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Caro Edelbroek, Michel Terheggen
INTRODUCTION: High-frequency spinal cord stimulation (HF SCS) is a relatively new modality of SCS. The present general advice concerning pregnancy and SCS, in general, is to turn the device off because of insufficient knowledge concerning the impact on the developing fetus. As HF stimulation generates higher energies, potential adverse fetal effects could be theoretically stronger. CASE: This case report describes a 36-year-old woman who had two pregnancies with an active HF SCS system...
December 2015: Neuromodulation: Journal of the International Neuromodulation Society
Jan S Burgerhart, Pim W J van Rutte, Michela A L Edelbroek, Dirk N J Wyndaele, Johannes F Smulders, Paul C van de Meeberg, Peter D Siersema, André J P M Smout
BACKGROUND: Laparoscopic sleeve gastrectomy (LSG) is an effective bariatric procedure. However, postprandial symptoms can compromise its beneficial effect. It is not known if a changed gastric emptying and these symptoms are related. This study aimed to assess the association between postprandial symptoms and the gastric emptying pattern after LSG. METHODS: A gastric emptying study with a solid and liquid meal component was performed in the second year after LSG...
February 2015: Obesity Surgery
Koen D Quint, Jeroen R J Edelbroek, A J Hans Gelderblom, Romco van Doorn, Maarten H Vermeer
BACKGROUND: Paraneoplastic dermatoses may be the first manifestation of a malignancy. Rapid recognition is therefore important. CASE DESCRIPTION: A 72-year-old woman who had been treated in the past for metastasised neuroendocrine carcinoma and had undergone curative treatment for stage-1c endometrial carcinoma developed three paraneoplastic dermatoses over a 2-year period: acanthosis nigricans, tripe palms and acquired hypertrichosis lanuginosa. Half a year later, cutaneous metastases derived from the endometrial carcinoma treated 12 years prior were discovered...
2013: Nederlands Tijdschrift Voor Geneeskunde
Gilles van Luijtelaar, Asht M Mishra, Peter Edelbroek, Daniel Coman, Nikita Frankenmolen, Pauline Schaapsmeerders, Giulio Covolato, Nathan Danielson, Hannah Niermann, Kryzstof Janeczko, Anne Kiemeneij, Julija Burinov, Chhitij Bashyal, Madeline Coquillette, Annika Lüttjohann, Fahmeed Hyder, Hal Blumenfeld, Clementina M van Rijn
The beneficial effects of chronic and early pharmacological treatment with ethosuximide on epileptogenesis were studied in a genetic absence epilepsy model comorbid for depression. It was also investigated whether there is a critical treatment period and treatment length. Cortical excitability in the form of electrical evoked potentials, but also to cortico-thalamo-cortical network activity (spike-wave discharges, SWD and afterdischarges), white matter changes representing extra cortico-thalamic functions and depressive-like behavior were investigated...
December 2013: Neurobiology of Disease
J R Edelbroek, M H Vermeer, P M Jansen, T J Stoof, M M D van der Linden, B Horváth, J van Baarlen, R Willemze
BACKGROUND: Langerhans cell histiocytosis (LCH) in adults first presenting in the skin is rare. Guidelines for staging, treatment and follow-up are lacking. OBJECTIVES: To better define staging procedures, treatment results and clinical course in adult patients with LCH first presenting in the skin. METHODS: Eighteen adult patients with LCH first presenting in the skin were collected from five centres collaborating in the Dutch Cutaneous Lymphoma Group...
December 2012: British Journal of Dermatology
D H Vu, J W C Alffenaar, P M Edelbroek, J R B J Brouwers, D R A Uges
Tuberculosis (TB) is a high-burden infectious disease, especially in low and middle-income countries. The efforts to eliminate this disease are challenged by the emergence of multidrug resistance and TB-HIV coinfection. The cumulative knowledge on pharmacokinetics/ pharmacodynamics of antituberculosis agents has recently encouraged therapeutic drug monitoring (TDM) in patient care. However, logistical problems related to conventional sampling limit the application of TDM in research-oriented institutions. Dried blood spot (DBS) compared with conventional venous blood sampling has the advantages of easier sampling, storage and transportation, thus enabling the application of TDM even in remote areas...
2011: Current Pharmaceutical Design
H Graf, S Fast, F Pacini, A Pinchera, A Leung, M Vaisman, C Reiners, J L Wemeau, D Huysmans, W Harper, A Driedger, H Noemberg de Souza, M G Castagna, L Antonangeli, L Braverman, R Corbo, C Düren, E Proust-Lemoine, M A Edelbroek, C Marriott, I Rachinsky, P Grupe, T Watt, J Magner, L Hegedus
BACKGROUND: Recombinant human TSH (rhTSH) can be used to enhance (131)I therapy for shrinkage of multinodular goiter (MG). OBJECTIVE, DESIGN, AND SETTING: The objective of the study was to compare the efficacy and safety of 0.01 and 0.03 mg modified-release (MR) rhTSH as an adjuvant to (131)I therapy, vs. (131)I alone, in a randomized, placebo-controlled, international, multicenter study. PATIENTS AND INTERVENTION: Ninety-five patients (57...
May 2011: Journal of Clinical Endocrinology and Metabolism
Monique M R de Maat, Henk J van Leeuwen, Peter M Edelbroek
OBJECTIVE: To describe a hypoalbuminemic critically ill patient with subtherapeutic total valproic acid serum concentrations but unbound valproic acid concentrations within normal limits. CASE SUMMARY: During an intensive care unit admission, a 61-year-old woman with urosepsis and multiorgan dysfunction syndrome developed tonic-clonic seizures with respiratory failure, and tracheal intubation was performed. An intravenous loading dose of valproic acid 1500 mg (25 mg/kg) was administered and therapy was continued with valproic acid 750 mg (12...
March 2011: Annals of Pharmacotherapy
Ilse Wegner, Peter Edelbroek, Gerrit-Jan de Haan, Dick Lindhout, Josemir W Sander
Little is known about pregnancy-induced alterations in the pharmacokinetics of the newer antiepileptic drugs, especially when used in combinations. Two women receiving combination therapy of lamotrigine (LTG) and oxcarbazepine (OXC) were followed prospectively during pregnancy and puerperium. Steady-state concentrations of LTG and the active metabolite of OXC, 10-hydroxycarbazepine (MHD), were measured at regular intervals using a dried blood spot method, and clearances were calculated. A strong effect of pregnancy on the clearance of both LTG and MHD was seen...
December 2010: Epilepsia
Martijn Goosens, Sietske A Smulders, Frank W Smeenk, Alette W Daniëls-Gooszen, Astrid B Donkers-van Rossum, Michela A Edelbroek, Dyde A Huysmans, Arent-Jan Michels, Bart A H M van Straten, Pieter E Postmus
PURPOSE: In this study, we investigated the impact of implementation of [(18)F] fluorodeoxyglucose positron emission tomography (FDG-PET) in daily practice on adherence to mediastinal staging protocols and performance of mediastinoscopy in non-small-cell lung cancer (NSCLC) patients who are possible candidates for surgical resection. Institutional review board approval was obtained. PATIENTS AND METHODS: From a nonuniversity teaching hospital and three surrounding community hospitals in Eindhoven, the Netherlands, we studied data from 143 patients with NSCLC who underwent mediastinoscopy and/or thoracotomy in three consecutive periods (1, 0 to 9 months; 2, 10 to 18 months; and 3, 19 to 31 months) after introduction of PET...
September 2007: Journal of Oncology Practice
Linda Holtman, Erwin A van Vliet, Peter M Edelbroek, Eleonora Aronica, Jan A Gorter
PURPOSE: Status epilepticus (SE) leads to upregulation of pro-inflammatory proteins including cyclooxygenase-2 (cox-2) which could be implicated in the epileptogenic process and epileptic seizures. Recent studies show that cox-2 can regulate expression of P-glycoprotein (P-gp) during epileptogenesis and epilepsy. P-gp could cause pharmacoresistance by reducing brain entry of anti-epileptic drugs such as phenytoin (PHT). Here we have investigated the effects of cox-2 inhibition on epileptogenesis, spontaneous seizures and PHT treatment in a rat model for temporal lobe epilepsy (TLE)...
September 2010: Epilepsy Research
Hermina C Wisgerhof, Jeroen R J Edelbroek, Johan W de Fijter, Geert W Haasnoot, Frans H J Claas, Rein Willemze, Jan N Bouwes Bavinck
BACKGROUND: The risk of skin cancer is highly increased in kidney-transplant recipients (KTR), but the risk of subsequent skin cancers is less well studied. The aim of this study was to estimate the cumulative incidence of subsequent squamous- and basal-cell carcinomas (BCCs) and to analyze potential risk factors. METHODS: All histologically confirmed skin cancers between 1966 and 2006 were included in the study and counted. Cumulative incidences of subsequent squamous- and BCCs were calculated using Kaplan-Meier survival analyses...
May 27, 2010: Transplantation
Patricia Bakvis, Philip Spinhoven, Erik J Giltay, Jarl Kuyk, Peter M Edelbroek, Frans G Zitman, Karin Roelofs
PURPOSE: Several studies have indicated that psychogenic nonepileptic seizures (PNES) are associated with psychological trauma, but only a few studies have examined the associations with neurobiologic stress systems, such as the hypothalamus-pituitary-adrenal (HPA) axis and its end-product cortisol. We tested several relevant HPA-axis functions in patients with PNES and related them to trauma history. METHODS: Cortisol awakening curve, basal diurnal cortisol, and negative cortisol feedback (using a 1 mg dexamethasone suppression test) were examined in 18 patients with PNES and 19 matched healthy controls (HCs) using saliva cortisol sampling on two consecutive days at 19 time points...
May 2010: Epilepsia
Ilse Wegner, Peter M Edelbroek, Saskia Bulk, Dick Lindhout
OBJECTIVE: We prospectively evaluated the fluctuation of lamotrigine (LTG) clearance during the menstrual cycle. We also assessed the effect of postmenopausal status and investigated in detail the effect of oral contraceptives (OCs) on LTG clearance. METHODS: Three groups of women with epilepsy using LTG monotherapy were evaluated. Women in the first group (n = 7) had a regular cycle and did not use OCs; the second group used a 1-phase combined OC (n = 7), and the third group (n = 7) was postmenopausal...
October 27, 2009: Neurology
Gerrit-Jan de Haan, Peter van der Geest, Gerard Doelman, Edward Bertram, Peter Edelbroek
Rectal diazepam is established as a standard rescue or emergency treatment for seizure or status epilepticus; however, the rectal route of administration has not been universally accepted. To determine if an alternative route of administration of a benzodiazepine was equally effective, we compared a novel midazolam HCl concentrated nasal spray (MDZ-n) with diazepam rectal solution (DZP-r) in the treatment of prolonged seizures in a residential epilepsy center. In 21 adult patients with medically refractory epilepsy, 124 seizure-exacerbations were treated by their caregivers, alternatively with 10 mg DZP-r and 10 mg concentrated MDZ-n, two or three treatments with each medication for each patient...
March 2010: Epilepsia
H C Wisgerhof, J R J Edelbroek, J W de Fijter, M C W Feltkamp, R Willemze, J N Bouwes Bavinck
BACKGROUND: Skin diseases are frequently observed in organ-transplant recipients (OTRs). OBJECTIVES: To count the registered skin diseases in all 2136 OTRs who had been transplanted in a single centre between 1966 and 2006 and to calculate their relative contribution in relation to the number of years after transplantation. METHODS: All registered skin diseases which were entered into a computerized system between 1994 and 2006 at the Leiden University Medical Centre were counted and their relative contributions were calculated...
February 1, 2010: British Journal of Dermatology
P Houthuizen, P E Polak, M A L Edelbroek, C H Peels
Giant cell arteritis (GCA) is a relatively infrequent disorder that is underdiagnosed and little appraised in the field of general cardiology. However, it is important to be familiar with the clinical picture of this disease, especially because of the risk of developing fatal aortic aneurysms. If the disease is suspected after a thorough history and clinical examination combined with laboratory investigation, the diagnosis can be confirmed with (18)F-2-deoxy-glucose positron emission tomographic (FDG-PET) imaging...
August 2009: Netherlands Heart Journal
Erwin A van Vliet, Guido Zibell, Anton Pekcec, Juli Schlichtiger, Peter M Edelbroek, Linda Holtman, Eleonora Aronica, Jan A Gorter, Heidrun Potschka
Epileptic seizures drive expression of the blood-brain barrier efflux transporter P-glycoprotein via a glutamate/cyclooxygenase-2 mediated signalling pathway. Targeting this pathway may represent an innovative approach to control P-glycoprotein expression in the epileptic brain and to enhance brain delivery of antiepileptic drugs. Therefore, we tested the effect of specific cyclooxygenase-2 inhibition on P-glycoprotein expression in two different status epilepticus models. Moreover, the impact of a cyclooxygenase-2 inhibitor on expression of the efflux transporter and on brain delivery of an antiepileptic drug was evaluated in rats with recurrent spontaneous seizures...
February 2010: Neuropharmacology
Erwin A van Vliet, Peter M Edelbroek, Jan A Gorter
PURPOSE: Tolerance to drug treatment is a serious problem in the treatment of epilepsy. We previously showed that tolerance to levetiracetam (LEV) developed within 4 days after the start of the treatment in a rat model for spontaneous seizures after electrically induced status epilepticus. In the current study we tested whether the development of tolerance to LEV could be prevented by alternating between LEV and valproate (VPA) treatment. METHODS: Before starting the alternating therapy with LEV and VPA (3 day LEV-3 day VPA, two cycles), we assessed the efficacy of VPA monotherapy by administering VPA to chronic epileptic rats via osmotic minipumps during 7 days...
March 2010: Epilepsia
Peter M Edelbroek, Jacques van der Heijden, Leo M L Stolk
This article reviews dried blood spot (DBS) sampling in therapeutic drug monitoring. The DBS method involves applying whole blood obtained via a fingerprick to a sampling paper. After drying and transportation, the blood spot is extracted and analyzed in the laboratory. Assays of many medicines in DBS have already been reported in the literature and are reviewed here. The technique involved in and factors that may influence the accuracy and reproducibility of DBS methods are also discussed. DBS sampling ultimately seems to be a useful technique for therapeutic drug monitoring that could have many advantages in comparison with conventional venous sampling...
June 2009: Therapeutic Drug Monitoring
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