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https://www.readbyqxmd.com/read/28223797/fabrication-and-in-vitro-in-vivo-evaluation-of-amorphous-andrographolide-nanosuspensions-stabilized-by-d-%C3%AE-tocopheryl-polyethylene-glycol-1000-succinate-sodium-lauryl-sulfate
#1
Hongzhi Qiao, Lihua Chen, Tianqi Rui, Jingxian Wang, Ting Chen, Tingming Fu, Junsong Li, Liuqing Di
Andrographolide (ADG) is a diterpenoid isolated from Andrographis paniculata with a wide spectrum of biological activities, including anti-inflammatory, anticancer and hepatoprotective effects. However, its poor water solubility and efflux by P-glycoprotein have resulted in lower bioavailability. In this study, ADG nanosuspensions (ADG-NS) were prepared using a wet media milling technique followed by freeze drying. d-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS), a surfactant that inhibits P-glycoprotein function, and sodium lauryl sulfate were used as surface stabilizers...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28131848/dehydroandrographolide-inhibits-oral-cancer-cell-migration-and-invasion-through-nf-%C3%AE%C2%BAb-ap-1-and-sp-1-modulated-matrix-metalloproteinase-2-inhibition
#2
Ming-Ju Hsieh, Jui-Chieh Chen, Wei-En Yang, Su-Yu Chien, Mu-Kuan Chen, Yu-Sheng Lo, Yi-Ting Hsi, Yi-Ching Chuang, Chia-Chieh Lin, Shun-Fa Yang
BACKGROUND AND PURPOSE: Oral cancer is a type of head and neck cancer that is characterized by cancerous tissue growth in the oral cavity. Andrographolide and dehydroandrographolide (DA) are the two principal components of Andrographis paniculata (Burm.f.) Nees and are the main contributors to its therapeutic properties. However, the pharmacological activities of DA remain unclear. EXPERIMENTAL APPROACH: In this study, we used wound closure assay and Boyden chamber assay to determine the effects of DA on oral cancer cell migration and invasion...
January 25, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28129629/hepatoprotective-effect-of-engineered-silver-nanoparticles-coated-bioactive-compounds-against-diethylnitrosamine-induced-hepatocarcinogenesis-in-experimental-mice
#3
Prasannaraj Govindaraj, Venkatachalam Perumal
Nanoparticle based drug delivery can rapidly improves the therapeutic potential of anti-cancer agents. The present study focused to evaluate the hepatoprotective activity of silver nanoparticles (AgNPs) synthesized using aqueous extracts of Andrographis paniculata leaves (ApAgNPs) and Semecarpus anacardium nuts (SaAgNPs) against diethylnitrosamine (DEN) induced liver cancer in mice model. The physico-chemical properties of synthesized AgNPs were characterized by Fourier transform infrared (FTIR) spectroscopy, Transmission Electron Microscopy (TEM), Selected Area Electron Diffraction (SAED), X-ray Diffraction (XRD), Energy Dispersive X-ray (EDX) spectrum, Zeta potential and Dynamic Light Scattering (DLS) analysis...
January 10, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28097636/andrographolide-antibacterial-activity-against-common-bacteria-of-human-health-concern-and-possible-mechanism-of-action
#4
Malabika Banerjee, Debaprasad Parai, Subrata Chattopadhyay, Samir Kumar Mukherjee
Increasing bacterial resistance to common drugs is a major public health concern for the treatment of infectious diseases. Certain naturally occurring compounds of plant sources have long been reported to possess potential antimicrobial activity. This study was aimed to investigate the antibacterial activity and possible mechanism of action of andrographolide (Andro), a diterpenoid lactone from a traditional medicinal herb Andrographis paniculata. Extent of antibacterial action was assessed by minimal bactericidal concentration method...
January 17, 2017: Folia Microbiologica
https://www.readbyqxmd.com/read/28049346/genoproteomics-assisted-improvement-of-andrographis-paniculata-toward-a-promising-molecular-and-conventional-breeding-platform-for-autogamous-plants-affecting-the-pharmaceutical-industry
#5
Alireza Valdiani, Daryush Talei, Surrinder K Lattoo, Rodomiro Ortiz, Søren Kjærsgaard Rasmussen, Jacqueline Batley, Mohd Yusop Rafii, Mahmood Maziah, Kallevettankuzhy K Sabu, Rambod Abiri, Suchirat Sakuanrungsirikul, Soon Guan Tan
Andrographis paniculata (Burm. f.) Wall. ex Nees. (AP) is a hermaphroditic, self-compatible, and habitual inbreeding plant. Its main bioactive component is andrographolide, which is capable of inducing autophagic cell death in some human cancer cells and helps fight HIV/AIDS. Increasing the andrographolide content by investigating the genetic mechanisms controlling its biosynthesis in order to improve and develop high-yielding cultivars are the main breeding targets for AP. However, there might exist some limitations or barriers for crossability within AP accessions...
January 3, 2017: Critical Reviews in Biotechnology
https://www.readbyqxmd.com/read/28034742/activity-of-andrographolide-against-dengue-virus
#6
Patcharee Panraksa, Suwipa Ramphan, Sarawut Khongwichit, Duncan R Smith
Dengue is the most prevalent arthropod-transmitted viral illness of humans, with an estimated 100 million symptomatic infections occurring each year and more than 2.5 billion people living at risk of infection. There are no approved antiviral agents against dengue virus, and there is only limited introduction of a dengue vaccine in some countries. Andrographolide is derived from Andrographis paniculata, a medicinal plant traditionally used to treat a number of conditions including infections. The antiviral activity of andrographolide against dengue virus (DENV) serotype 2 was evaluated in two cell lines (HepG2 and HeLa) while the activity against DENV 4 was evaluated in one cell line (HepG2)...
December 26, 2016: Antiviral Research
https://www.readbyqxmd.com/read/27984106/andrographolide-loaded-polymerized-phenylboronic-acid-nanoconstruct-for-stimuli-responsive-chemotherapy
#7
Jinhwan Kim, Junseok Lee, Yeong Mi Lee, Swapan Pramanick, Sooseok Im, Won Jong Kim
Along with the successful discovery of paclitaxel as an anticancer drug, natural products have drawn great attention in drug discovery. Recently, andrographolide (AND) from Andrographis paniculata was reported to provide several benefits, including an anticancer effect. However, the extremely low solubility of the compound in an aqueous medium was an obstacle to overcome for the systemic administration and clinical application of AND. Based on our previous report, we formulated a water-soluble nanoconstruct by forming a boronic ester between the cis-1,3-diol of AND with hydrophilically polymerized phenylboronic acid (pPBA)...
October 27, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27926533/andrographolide-impedes-cancer-stemness-and-enhances-radio-sensitivity-in-oral-carcinomas-via-mir-218-activation
#8
Po-Yu Yang, Pei-Ling Hsieh, Tong Hong Wang, Cheng-Chia Yu, Ming-Yi Lu, Yi-Wen Liao, Tzu-Hsin Lee, Chih-Yu Peng
Current evidence suggests that oral cancer stem cells (OCSCs) possess high tumorigenic and metastatic properties as well as chemo- and radioresistance. In this study, we demonstrated that andrographolide, the main bioactive component in the medicinal plant Andrographis, significantly reduced oncogenicity and restored radio-sensitivity of ALDH1+CD44+ OCSCs. Mechanistic studies showed that andrographolide treatment increased the expression of microRNA-218 (miR-218), leading to the downregulation of Bmi1. We showed that knockdown of miR-218 in ALDH1-CD44- non-OCSCs enhanced cancer stemness, while silencing of Bmi1 significantly counteracted it...
December 1, 2016: Oncotarget
https://www.readbyqxmd.com/read/27896563/broad-spectrum-antiviral-properties-of-andrographolide
#9
REVIEW
Swati Gupta, K P Mishra, Lilly Ganju
Andrographolide, a diterpenoid, is known for its anti-inflammatory effects. It can be isolated from various plants of the genus Andrographis, commonly known as 'creat'. This purified compound has been tested for its anti-inflammatory effects in various stressful conditions, such as ischemia, pyrogenesis, arthritis, hepatic or neural toxicity, carcinoma, and oxidative stress, Apart from its anti-inflammatory effects, andrographolide also exhibits immunomodulatory effects by effectively enhancing cytotoxic T cells, natural killer (NK) cells, phagocytosis, and antibody-dependent cell-mediated cytotoxicity (ADCC)...
November 28, 2016: Archives of Virology
https://www.readbyqxmd.com/read/27887650/the-anti-inflammatory-effect-of-andrographis-paniculata-burm-f-nees-on-pelvic-inflammatory-disease-in-rats-through-down-regulation-of-the-nf-%C3%AE%C2%BAb-pathway
#10
Wei Zou, Zuoqi Xiao, Xiaoke Wen, Jieying Luo, Shuqiong Chen, Zeneng Cheng, Daxiong Xiang, Jian Hu, Jingyu He
BACKGROUND: Andrographis paniculata (Burm. f.) Nees (APN), a principal constituent of a famous traditional Chinese medicine Fukeqianjin tablet which is used for the treatment of pelvic inflammatory disease (PID), has been reported to have anti-inflammatory effect in vitro. However, whether it has pharmacological effect on PID in vivo is unclear. Therefore, the aim of this study is to test the anti-inflammatory effect of APN and illuminate a potential mechanism. METHODS: Thirty-six female specific pathogen-free SD rats were randomly divided into control group, PID group, APN1 group, APN2 group, APN3 group and prednisone group...
November 25, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27847337/herb-drug-interaction-of-andrographis-paniculata-nees-extract-and-andrographolide-on-pharmacokinetic-and-pharmacodynamic-of-naproxen-in-rats
#11
Aishwarya Balap, Sathiyanarayanan Lohidasan, Arulmozhi Sinnathambi, Kakasaheb Mahadik
ETHNOPHARMACOLOGICAL RELEVANCE: Andrographis paniculata Nees (Acanthacae) have broad range of pharmacological effects such as hepatoprotective, antifertility, antimalarial, antidiabetic, suppression of various cancer cells and anti-inflammatory properties and is widely used medicinal plant in the traditional Unani and Ayurvedic medicinal systems. Andrographolide (AN) is one of the active constituent of the A. paniculata Nees extract (APE). They have been found in many traditional herbal formulations in India and proven to be effective as anti-inflammatory drug...
January 4, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27846838/effects-of-shenlian-extract-on-experimental-atherosclerosis-in-apoe-deficient-mice-based-on-ultrasound-biomicroscopy
#12
Yan Guo, Xu-Cen Liu, Ya-Jie Wang, Qi Li, Qing Yang, Xiao-Gang Weng, Ying Chen, Wei-Yan Cai, Xiao-Xi Kan, Xi Chen, He-Fei Huang, Xiao-Xin Zhu, Yu-Jie Li
BACKGROUND: This study directly and dynamically investigated the effects of SL extract (i.e., a combination of Radix Salviae miltiorrhizae and Andrographis paniculata extract) on plaque progression in vivo by high resolution ultrasound biomicroscopy (UBM). METHODS: An atherosclerosis model was established by placing a perivascular collar on the right common carotid artery in apolipoprotein E-deficient (ApoE(-/-)) mice. Thickness, plaque area and local blood flow were observed by UBM, pathological changes were observed by histochemical staining, and lipid levels were measured by respective commercially available kits...
November 15, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27836761/effect-of-holarrhena-antidysentrica-ha-and-andrographis-paniculata-ap-on-the-biofilm-formation-and-cell-membrane-integrity-of-opportunistic-pathogen-salmonella-typhimurium
#13
Ankit Tanwar, Raman Chawla, Ankita Singh Chakotiya, Pallavi Thakur, Rajeev Goel, Mitra Basu, Rajesh Arora, Haider Ali Khan
Increasing occurrence of gastroenteritis outbreaks caused by food borne opportunistic microorganisms has become a major problem in food industry as well as in immunocompromised host. Antimicrobial agents are losing their efficacy due to increase in the microbial resistance. For such reasons, conventional treatment has become limited to manage the infections state. Need of the hour is to instigate the search for safer holistic alternatives. The present study was hence conducted to assess the antibiofilm effect and mode of action of aquo alcoholic extracts of Holarrhena antidysentrica (Ha) and Andrographis paniculata (Ap) against the Salmonella enterica serovar typhimurium...
December 2016: Microbial Pathogenesis
https://www.readbyqxmd.com/read/27816824/biochemical-and-histochemical-analyses-revealing-endophytic-alcaligenes-faecalis-mediated-suppression-of-oxidative-stress-in-abelmoschus-esculentus-challenged-with-sclerotium-rolfsii
#14
Shatrupa Ray, Vivek Singh, Surendra Singh, Birinchi Kumar Sarma, Harikesh Bahadur Singh
Sclerotium rolfsii is a highly aggressive pathogen that causes huge economic losses, especially in temperate climates. Alcaligenes faecalis, particularly in endophytic form, has rarely been used to control this fungus. In this study, endophytic Alcaligenes sp. strain BHU 12, BHU 16 (isolated from Abelmoschus esculentus leaf) and BHU M7 (isolated from Andrographis paniculata leaf) were reported to trigger a wide range of host defenses in Okra plant against the collar-rot pathogen S. rolfsii. Endophytic colonization of the strains in ten days old plants was assessed through re-isolation of the rif-tagged strains on rifampicin augmented nutrient agar media...
December 2016: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/27812015/understanding-the-antifungal-mechanism-of-ag-zno-core-shell-nanocomposites-against-candida-krusei
#15
Bhaskar Das, Md Imran Khan, R Jayabalan, Susanta K Behera, Soon-Il Yun, Suraj K Tripathy, Amrita Mishra
In the present paper, facile synthesis of Ag@ZnO core-shell nanocomposites is reported where zinc oxide is coated on biogenic silver nanoparticles synthesized using Andrographis paniculata and Aloe vera leaf extract. Structural features of as synthesized nanocomposites are characterized by UV-visible spectroscopy, XRD, and FTIR. Morphology of the above core-shell nanocomposites is investigated by electron microscopy. As synthesized nanocomposite material has shown antimicrobial activity against Candida krusei, which is an opportunistic pathogen known to cause candidemia...
November 4, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27793918/cytotoxic-components-against-human-oral-squamous-cell-carcinoma-isolated-from-andrographis-paniculata
#16
Ryuichiro Suzuki, Yasuaki Matsushima, Noriyuki Okudaira, Hiroshi Sakagami, Yoshiaki Shirataki
BACKGROUND: The 5-year survival rate of patients with oral cancer has remained approximately 50% during the past 30 years, possibly due to the poor tumor selectivity of conventional anticancer drugs. This prompted us to search for new candidates for anticancer drugs that have higher cytotoxicity and tumor selectivity. MATERIALS AND METHODS: Dried leaves of Andrographis paniculata were supplied from a market in Shanghai. The methanolic fraction of A. paniculata was further fractionated to identify cytotoxic principles by spectroscopic analysis and comparison with literature values...
2016: Anticancer Research
https://www.readbyqxmd.com/read/27769076/the-role-of-dietary-supplements-in-inflammatory-bowel-disease-a-systematic-review
#17
Roberta E Rossi, Tara Whyand, Charles D Murray, Mark I Hamilton, Dario Conte, Martyn E Caplin
Inflammatory bowel diseases (IBD) are chronic immune disorders of unclear aetiology. Dietary deficiencies may be a potential pathogenic factor in their development. Patients often take food supplements without knowledge of any evidence base. We have therefore assessed the evidence for food supplementation in the management of IBD. A PubMed search was performed for the terms Inflammatory bowel disease; nutritional deficiencies; dietary supplements; curcumin; green tea; vitamin D/other vitamins; folic acid; iron; zinc; probiotics; andrographis paniculata; and boswellia serrate...
December 2016: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27765367/herbalog-a-tool-for-target-based-identification-of-herbal-drug-efficacy-through-molecular-docking
#18
Yan Wang, Jian-Shu Hu, Huang-Quan Lin, Tsz-Ming Ip, David Chi-Cheong Wan
BACKGROUND: Traditionally, molecular docking is primarily employed to screen pure compounds; the top-ranking chemicals are subsequently selected for experimental validation. Unlike synthetic chemicals, most natural products are commercially unavailable. The isolation and purification of each natural product is extremely time-consuming, which has restricted the screening of lead compounds from natural products. PURPOSE: We developed a protocol, Herbalog, to facilitate the identification of bioactive phytochemicals through molecular docking...
November 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/27714886/pharmacokinetic-and-pharmacodynamic-interaction-of-andrographolide-and-standardized-extract-of-andrographis-paniculata-nees-with-nabumetone-in-wistar-rats
#19
Aishwarya Balap, Sathiyanarayanan Lohidasan, Arulmozhi Sinnathambi, Kakasaheb Mahadik
The aim of the study was to investigate the herb-drug interaction of Andrographis paniculata Nees (Acanthaceae) and Andrographolide (AN) with nabumetone (NAB) in wistar rats. Pharmacokinetic and pharmacodynamic interactions were studied after co-administration of APE and AN with NAB in Wistar rats. In pharmacokinetic studies, significant decrease in Cmax, AUC0-t and AUC0-∞ of 6-MNA after co-administration with pure AN and APE has been observed. Tmax of 6-MNA has been increased to 2 h from 1.5 h in AN + NAB treated group...
January 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/27702690/andrographis-paniculata-dissolution-investigation-and-pharmacokinetic-studies-of-four-major-active-diterpenoids-after-multiple-oral-dose-administration-in-healthy-thai-volunteers
#20
Nanthanit Pholphana, Duangchit Panomvana, Nuchanart Rangkadilok, Tawit Suriyo, Porranee Puranajoti, Teerapat Ungtrakul, Wanwisa Pongpun, Saichit Thaeopattha, Phanit Songvut, Jutamaad Satayavivad
ETHNOPHARMACOLOGICAL RELEVANCE: Andrographis paniculata is included in 'The National List of Essential Herbal Drugs A.D. 1999' of Thailand as an herbal drug for the treatment of common cold symptoms and non-infectious diarrhea. The therapeutic activities of A. paniculata are attributed to four major active diterpenoids: andrographolide (1), 14-deoxy-11, 12-didehydroandrographolide (2), neoandrographolide (3), and 14-deoxyandrographolide (4). However, the pharmacokinetic studies in humans of this plant were performed after a single oral dose administration and reported the parameters related to be of only 1...
December 24, 2016: Journal of Ethnopharmacology
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