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Andrographis

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https://www.readbyqxmd.com/read/27926533/andrographolide-impedes-cancer-stemness-and-enhances-radio-sensitivity-in-oral-carcinomas-via-mir-218-activation
#1
Po-Yu Yang, Pei-Ling Hsieh, Tong Hong Wang, Cheng-Chia Yu, Ming-Yi Lu, Yi-Wen Liao, Tzu-Hsin Lee, Chih-Yu Peng
Current evidence suggests that oral cancer stem cells (OCSCs) possess high tumorigenic and metastatic properties as well as chemo- and radioresistance. In this study, we demonstrated that andrographolide, the main bioactive component in the medicinal plant Andrographis, significantly reduced oncogenicity and restored radio-sensitivity of ALDH1+CD44+ OCSCs. Mechanistic studies showed that andrographolide treatment increased the expression of microRNA-218 (miR-218), leading to the downregulation of Bmi1. We showed that knockdown of miR-218 in ALDH1-CD44- non-OCSCs enhanced cancer stemness, while silencing of Bmi1 significantly counteracted it...
December 1, 2016: Oncotarget
https://www.readbyqxmd.com/read/27896563/broad-spectrum-antiviral-properties-of-andrographolide
#2
REVIEW
Swati Gupta, K P Mishra, Lilly Ganju
Andrographolide, a diterpenoid, is known for its anti-inflammatory effects. It can be isolated from various plants of the genus Andrographis, commonly known as 'creat'. This purified compound has been tested for its anti-inflammatory effects in various stressful conditions, such as ischemia, pyrogenesis, arthritis, hepatic or neural toxicity, carcinoma, and oxidative stress, Apart from its anti-inflammatory effects, andrographolide also exhibits immunomodulatory effects by effectively enhancing cytotoxic T cells, natural killer (NK) cells, phagocytosis, and antibody-dependent cell-mediated cytotoxicity (ADCC)...
November 28, 2016: Archives of Virology
https://www.readbyqxmd.com/read/27887650/the-anti-inflammatory-effect-of-andrographis-paniculata-burm-f-nees-on-pelvic-inflammatory-disease-in-rats-through-down-regulation-of-the-nf-%C3%AE%C2%BAb-pathway
#3
Wei Zou, Zuoqi Xiao, Xiaoke Wen, Jieying Luo, Shuqiong Chen, Zeneng Cheng, Daxiong Xiang, Jian Hu, Jingyu He
BACKGROUND: Andrographis paniculata (Burm. f.) Nees (APN), a principal constituent of a famous traditional Chinese medicine Fukeqianjin tablet which is used for the treatment of pelvic inflammatory disease (PID), has been reported to have anti-inflammatory effect in vitro. However, whether it has pharmacological effect on PID in vivo is unclear. Therefore, the aim of this study is to test the anti-inflammatory effect of APN and illuminate a potential mechanism. METHODS: Thirty-six female specific pathogen-free SD rats were randomly divided into control group, PID group, APN1 group, APN2 group, APN3 group and prednisone group...
November 25, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27847337/herb-drug-interaction-of-andrographis-paniculata-nees-extract-and-andrographolide-on-pharmacokinetic-and-pharmacodynamic-of-naproxen-in-rats
#4
Aishwarya Balap, Sathiyanarayanan Lohidasan, Arulmozhi Sinnathambi, Kakasaheb Mahadik
ETHNOPHARMACOLOGICAL RELEVANCE: Andrographis paniculata Nees (Acanthacae) have broad range of pharmacological effects such as hepatoprotective, antifertility, antimalarial, antidiabetic, suppression of various cancer cells and anti-inflammatory properties and is widely used medicinal plant in the traditional Unani and Ayurvedic medicinal systems. Andrographolide (AN) is one of the active constituent of the A. paniculata Nees extract (APE). They have been found in many traditional herbal formulations in India and proven to be effective as anti-inflammatory drug...
November 12, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27846838/effects-of-shenlian-extract-on-experimental-atherosclerosis-in-apoe-deficient-mice-based-on-ultrasound-biomicroscopy
#5
Yan Guo, Xu-Cen Liu, Ya-Jie Wang, Qi Li, Qing Yang, Xiao-Gang Weng, Ying Chen, Wei-Yan Cai, Xiao-Xi Kan, Xi Chen, He-Fei Huang, Xiao-Xin Zhu, Yu-Jie Li
BACKGROUND: This study directly and dynamically investigated the effects of SL extract (i.e., a combination of Radix Salviae miltiorrhizae and Andrographis paniculata extract) on plaque progression in vivo by high resolution ultrasound biomicroscopy (UBM). METHODS: An atherosclerosis model was established by placing a perivascular collar on the right common carotid artery in apolipoprotein E-deficient (ApoE(-/-)) mice. Thickness, plaque area and local blood flow were observed by UBM, pathological changes were observed by histochemical staining, and lipid levels were measured by respective commercially available kits...
November 15, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27836761/effect-of-holarrhena-antidysentrica-ha-and-andrographis-paniculata-ap-on-the-biofilm-formation-and-cell-membrane-integrity-of-opportunistic-pathogen-salmonella-typhimurium
#6
Ankit Tanwar, Raman Chawla, Ankita Singh Chakotiya, Pallavi Thakur, Rajeev Goel, Mitra Basu, Rajesh Arora, Haider Ali Khan
Increasing occurrence of gastroenteritis outbreaks caused by food borne opportunistic microorganisms has become a major problem in food industry as well as in immunocompromised host. Antimicrobial agents are losing their efficacy due to increase in the microbial resistance. For such reasons, conventional treatment has become limited to manage the infections state. Need of the hour is to instigate the search for safer holistic alternatives. The present study was hence conducted to assess the antibiofilm effect and mode of action of aquo alcoholic extracts of Holarrhena antidysentrica (Ha) and Andrographis paniculata (Ap) against the Salmonella enterica serovar typhimurium...
November 9, 2016: Microbial Pathogenesis
https://www.readbyqxmd.com/read/27816824/biochemical-and-histochemical-analyses-revealing-endophytic-alcaligenes-faecalis-mediated-suppression-of-oxidative-stress-in-abelmoschus-esculentus-challenged-with-sclerotium-rolfsii
#7
Shatrupa Ray, Vivek Singh, Surendra Singh, Birinchi Kumar Sarma, Harikesh Bahadur Singh
Sclerotium rolfsii is a highly aggressive pathogen that causes huge economic losses, especially in temperate climates. Alcaligenes faecalis, particularly in endophytic form, has rarely been used to control this fungus. In this study, endophytic Alcaligenes sp. strain BHU 12, BHU 16 (isolated from Abelmoschus esculentus leaf) and BHU M7 (isolated from Andrographis paniculata leaf) were reported to trigger a wide range of host defenses in Okra plant against the collar-rot pathogen S. rolfsii. Endophytic colonization of the strains in ten days old plants was assessed through re-isolation of the rif-tagged strains on rifampicin augmented nutrient agar media...
October 25, 2016: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/27812015/understanding-the-antifungal-mechanism-of-ag-zno-core-shell-nanocomposites-against-candida-krusei
#8
Bhaskar Das, Md Imran Khan, R Jayabalan, Susanta K Behera, Soon-Il Yun, Suraj K Tripathy, Amrita Mishra
In the present paper, facile synthesis of Ag@ZnO core-shell nanocomposites is reported where zinc oxide is coated on biogenic silver nanoparticles synthesized using Andrographis paniculata and Aloe vera leaf extract. Structural features of as synthesized nanocomposites are characterized by UV-visible spectroscopy, XRD, and FTIR. Morphology of the above core-shell nanocomposites is investigated by electron microscopy. As synthesized nanocomposite material has shown antimicrobial activity against Candida krusei, which is an opportunistic pathogen known to cause candidemia...
November 4, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27793918/cytotoxic-components-against-human-oral-squamous-cell-carcinoma-isolated-from-andrographis-paniculata
#9
Ryuichiro Suzuki, Yasuaki Matsushima, Noriyuki Okudaira, Hiroshi Sakagami, Yoshiaki Shirataki
BACKGROUND: The 5-year survival rate of patients with oral cancer has remained approximately 50% during the past 30 years, possibly due to the poor tumor selectivity of conventional anticancer drugs. This prompted us to search for new candidates for anticancer drugs that have higher cytotoxicity and tumor selectivity. MATERIALS AND METHODS: Dried leaves of Andrographis paniculata were supplied from a market in Shanghai. The methanolic fraction of A. paniculata was further fractionated to identify cytotoxic principles by spectroscopic analysis and comparison with literature values...
November 2016: Anticancer Research
https://www.readbyqxmd.com/read/27769076/the-role-of-dietary-supplements-in-inflammatory-bowel-disease-a-systematic-review
#10
Roberta E Rossi, Tara Whyand, Charles D Murray, Mark I Hamilton, Dario Conte, Martyn E Caplin
Inflammatory bowel diseases (IBD) are chronic immune disorders of unclear aetiology. Dietary deficiencies may be a potential pathogenic factor in their development. Patients often take food supplements without knowledge of any evidence base. We have therefore assessed the evidence for food supplementation in the management of IBD. A PubMed search was performed for the terms Inflammatory bowel disease; nutritional deficiencies; dietary supplements; curcumin; green tea; vitamin D/other vitamins; folic acid; iron; zinc; probiotics; andrographis paniculata; and boswellia serrate...
December 2016: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27765367/herbalog-a-tool-for-target-based-identification-of-herbal-drug-efficacy-through-molecular-docking
#11
Yan Wang, Jian-Shu Hu, Huang-Quan Lin, Tsz-Ming Ip, David Chi-Cheong Wan
BACKGROUND: Traditionally, molecular docking is primarily employed to screen pure compounds; the top-ranking chemicals are subsequently selected for experimental validation. Unlike synthetic chemicals, most natural products are commercially unavailable. The isolation and purification of each natural product is extremely time-consuming, which has restricted the screening of lead compounds from natural products. PURPOSE: We developed a protocol, Herbalog, to facilitate the identification of bioactive phytochemicals through molecular docking...
November 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/27714886/pharmacokinetic-and-pharmacodynamic-interaction-of-andrographolide-and-standardized-extract-of-andrographis-paniculata-nees-with-nabumetone-in-wistar-rats
#12
Aishwarya Balap, Sathiyanarayanan Lohidasan, Arulmozhi Sinnathambi, Kakasaheb Mahadik
The aim of the study was to investigate the herb-drug interaction of Andrographis paniculata Nees (Acanthaceae) and Andrographolide (AN) with nabumetone (NAB) in wistar rats. Pharmacokinetic and pharmacodynamic interactions were studied after co-administration of APE and AN with NAB in Wistar rats. In pharmacokinetic studies, significant decrease in Cmax, AUC0-t and AUC0-∞ of 6-MNA after co-administration with pure AN and APE has been observed. Tmax of 6-MNA has been increased to 2 h from 1.5 h in AN + NAB treated group...
October 7, 2016: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/27702690/andrographis-paniculata-dissolution-investigation-and-pharmacokinetic-studies-of-four-major-active-diterpenoids-after-multiple-oral-dose-administration-in-healthy-thai-volunteers
#13
Nanthanit Pholphana, Duangchit Panomvana, Nuchanart Rangkadilok, Tawit Suriyo, Porranee Puranajoti, Teerapat Ungtrakul, Wanwisa Pongpun, Saichit Thaeopattha, Phanit Songvut, Jutamaad Satayavivad
ETHNOPHARMACOLOGICAL RELEVANCE: Andrographis paniculata is included in 'The National List of Essential Herbal Drugs A.D. 1999' of Thailand as an herbal drug for the treatment of common cold symptoms and non-infectious diarrhea. The therapeutic activities of A. paniculata are attributed to four major active diterpenoids: andrographolide (1), 14-deoxy-11, 12-didehydroandrographolide (2), neoandrographolide (3), and 14-deoxyandrographolide (4). However, the pharmacokinetic studies in humans of this plant were performed after a single oral dose administration and reported the parameters related to be of only 1...
October 1, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27697058/multi-targeting-andrographolide-and-its-natural-analogs-as-potential-therapeutic-agents
#14
V Kishore, Nagend Nagendra Sastry Yarla, Anupam Bishayee, Swathi Putta, Ramarao Malla, Nageswara Rao Reddy Neelapu, Yallappa Shiralgi, Gurumurthy Hegde, Bhadrapura Lakkappa Dhananjaya
Andrographis paniculata (A. paniculata), a medicinal plant used in the traditional Indian and Chinese medicinal systems for its various beneficial properties owing to the presence of a diterpene lactone called 'andrographolide'. Several biological activities like anti-inflammatory, antitumour, anti-hyperglycaemic, anti-fertility, antiviral, cardio protective and hepatoprotective properties are attributed to andrographolide and its analogs. The studies have shown that not only this diterpene lactone (andrographolide), and other related terpenoid analogs from A...
September 27, 2016: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/27695271/inhibition-of-human-cytochrome-p450-2c8-catalyzed-amodiaquine-n-desethylation-effect-of-five-traditionally-and-commonly-used-herbs
#15
Yasotha Devi Muthiah, Chin Eng Ong, Siti Amrah Sulaiman, Rusli Ismail
BACKGROUND: In Southeast Asia and many parts of the world, herbal products are increasingly used in parallel with modern medicine. OBJECTIVE: This study aimed to investigate the effects of herbs commonly used in Southeast Asia on activity of cytochrome P450 2C8 (CYP2C8), an important human hepatic enzyme in drug metabolism. MATERIALS AND METHODS: The selected herbs, such as Eurycoma longifolia Jack (ELJ), Labisia pumila (LP), Echinacea purpurea (EP), Andrographis paniculata (AP), and Ginkgo biloba (GB), were subjected to inhibition studies using an in vitro CYP2C8 activity marker, amodiaquine N-desethylase assay...
October 2016: Pharmacognosy Research
https://www.readbyqxmd.com/read/27693317/andrographolide-reversed-5-fu-resistance-in-human-colorectal-cancer-by-elevating-bax-expression
#16
Weicheng Wang, Wenjie Guo, Lele Li, Zan Fu, Wen Liu, Jian Gao, Yongqian Shu, Qiang Xu, Yang Sun, Yanhong Gu
5-FU is the first line therapy for colorectal cancer, however, treatment effect is often hampered by the development of drug resistance or toxicity at high doses. Andrographolide is a natural diterpenoid from Andrographis paniculata which has anti-bacterial, anti-antiviral and anti-inflammation activities. In the current study, we test the hypothesis that Andrographolide reverses 5-FU resistance in colorectal cancer and examine the underlying mechanism. In vitro and vivo studies indicated that Andrographolide treatment significantly re-sensitizes HCT116/5-FUR cells (HCT116 cells which are 5-FU resistant) to cytotoxicity of 5-FU...
October 1, 2016: Biochemical Pharmacology
https://www.readbyqxmd.com/read/27667514/a-new-biocompatible-microemulsion-increases-extraction-yield-and-bioavailability-of-andrographis-paniculata
#17
Xiao-Yan Liu, Xin Niu, Qian-Jin Feng, Xue-Zhi Yang, Dan-Wei Wang, Tong Zhao, Lei Li, Hong DU
The purpose of this study was to design and prepare a biocompatible microemulsion of Andrographis paniculata (BMAP) containing both fat-soluble and water-soluble constituents. We determined the contents of active constituents of BMAP and evaluated its bioavailability. The biocompatible microemulsion (BM), containing lecithin and bile salts, was optimized in the present study, showing a good physical stability. The mean droplet size was 19.12 nm, and the average polydispersity index (PDI) was 0.153. The contents of andrographolide and dehydroandrographolide in BMAP, as determined by high performance liquid chromatography (HPLC), were higher than that in ethanol extraction...
September 2016: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/27663973/andrographolide-induces-nrf2-and-heme-oxygenase-1-in-astrocytes-by-activating-p38-mapk-and-erk
#18
Siew Ying Wong, Michelle G K Tan, Peter T H Wong, Deron R Herr, Mitchell K P Lai
BACKGROUND: Andrographolide is the major labdane diterpenoid originally isolated from Andrographis paniculata and has been shown to have anti-inflammatory and antioxidative effects. However, there is a dearth of studies on the potential therapeutic utility of andrographolide in neuroinflammatory conditions. Here, we aimed to investigate the mechanisms underlying andrographolide's effect on the expression of anti-inflammatory and antioxidant heme oxygenase-1 (HO-1) in primary astrocytes...
2016: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/27613615/a-phenylurea-cytokinin-cppu-elevated-reducing-sugar-and-correlated-to-andrographolide-contents-in-leaves-of-andrographis-paniculata-burm-f-wall-ex-nees
#19
Phapawee Worakan, Netiya Karaket, Nuchada Maneejantra, Kanyaratt Supaibulwatana
Cytokinins are phytohormones that play multiple roles to control plant growth and development. In this study, leaf biomass and the production of andrographolide compounds in a medicinal plant Andrographis paniculata were significantly increased after exogenously treating with the synthetic cytokinin cytokinin-1-(2-chloro-4-pyridyl)-3-phenylurea (CPPU) at 0 (water), 5, or 10 mg L(-1) and observed the results for 24 h, 48 h, and 7 days of treatment. It was found that CPPU could significantly enhance new axillary bud formation and further promote branching 4...
September 9, 2016: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/27599453/pro%C3%A2-neurogenic-effects-of-andrographolide-on-rsc96-schwann-cells-in%C3%A2-vitro
#20
Fuben Xu, Huayu Wu, Kun Zhang, Peizhen Lv, Li Zheng, Jinmin Zhao
Nerve regeneration remains a challenge to the treatment of peripheral nerve injury. Andrographolide (Andro) is the main active constituent of Andrographis paniculata, which has been applied in the treatment of several diseases, including inflammation, in ancient China. Andro has been reported to facilitate the reduction of edema and to exert analgesic effects in the treatment of various diseases. These findings suggest that Andro may be considered a promising anti‑inflammatory agent that may suppress destruction and accelerate proliferation of Schwann cells following peripheral nerve injury...
October 2016: Molecular Medicine Reports
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