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https://www.readbyqxmd.com/read/29152129/protective-effect-of-dehydroandrographolide-on-obstructive-cholestasis-in-bile-duct-ligated-mice
#1
Zhiyong Weng, Xuefeng Liu, Jiehua Hu, Jingzhou Mu, Jing Xie, Chenjuan Yao, Lihua Li
Background: Dehydroandrographolide (DA) is the main contributor to the therapeutic properties of the medicinal plant Andrographis paniculata (AP). However, it is unknown whether DA has a hepatoprotective effect on obstructive cholestasis in mice and humans. Methods: We administered DA to mice for 5 days prior to bile duct ligation (BDL) and for the 7 days. Liver function markers, liver histology and necrosis, compensatory responses of hepatocytes, liver fibrosis and the expression of hepatic fibrogenesis markers were evaluated in BDL mice and/or human LX-2 cells...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29146293/andrographolide-a-promising-therapeutic-agent-negatively-regulates-glial-cell-derived-neurodegeneration-of-prefrontal-cortex-hippocampus-and-working-memory-impairment
#2
Sudeshna Das, K P Mishra, Lilly Ganju, S B Singh
Over activation of glial cell derived innate immune factors induces neuro-inflammation that results in neurodegenerative disease, like working memory impairment. In this study, we have investigated the role of andrographolide, a major constituent of Andrographis paniculata plant, in reduction of reactive glial cell derived working memory impairment. Real time PCR, Western bloting, flow cytometric and immunofluorescence studies demonstrated that andrographolide inhibited lipopolysaccharide (LPS)-induced overexpression of HMGB1, TLR4, NFκB, COX-2, iNOS, and release of inflammatory mediators in primary mix glial culture, adult mice prefrontal cortex and hippocampus region...
November 8, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29143537/camphor-sulphonic-acid-mediated-quantitative-1-3-diol-protection-of-major-labdane-diterpenes-isolated-from-andrographis-paniculata
#3
Venu Sharma, Kamal K Kapoor, Debaraj Mukherjee, Vivek K Gupta, Manoj K Dhar, Sanjana Kaul
Phytochemical survey of the methanol extract of the dried aerial parts of Andrographis paniculata led to the isolation of major labdane diterpenes, namely 14-deoxy-11,12-didehydroandrographolide, andrographolide and neoandrographolide. Andrographolide was found to be the major phytoconstituent of the plant which was biologically active. For better physiochemical characteristics and bioefficacy, andrographolide is subjected to semi-synthetic modifications. However, presence of several free hydroxyl groups associated with this molecule make it quite polar and poorly soluble in many organic solvents and hence unsuitable for synthetic modifications...
November 16, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29133027/nutrient-analysis-of-kunapa-jala-and-pancha-gavya-and-their-evaluation-on-germination-of-ashwagandha-withania-somnifera-dunal-and-kalamegha-andrographis-paniculata-nees-seeds-a-comparative-study
#4
Gireesh M Ankad, Jagadishchandra Hiremath, R T Patil, H J Pramod, Harsha V Hegde
BACKGROUND: Vrikshayurveda, an ancient science of plant life described by Surapala, deals with healthy growth and productivity of plants, which has clearly outlined a systematized agricultural practice that insisted the use of Kunapa jala (KJ) and Pancha gavya (PG). OBJECTIVE: An experiment was conducted to validate KJ and PG by nutrient analysis and their effect on the germination parameters of Ashwagandha and Kalamegha seeds in comparison with other treatment groups...
November 10, 2017: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/29111187/a-review-of-five-traditionally-used-anti-diabetic-plants-of-bangladesh-and-their-pharmacological-activities
#5
REVIEW
Md Rajdoula Rafe
Plants are used traditionally throughout the globe to treat various diseases. Traditionally used medicinal plants are an essential part of the health sector in Bangladesh due to its abundance of a vast source of ethno-medicine. Rural people from developing country like Bangladesh are greatly dependent on traditional source of medicine. The prevalence of diabetes mellitus is increasing from recent years; therefore various researches are going on to discover better medicine to treat this disease. This study has focused on five plants which are Andrographis paniculata, Ageratum conyzoides, Swertia chirata, Terminalia arjuna, and Azadirachta indica to find out their traditional formulation as anti-diabetic medicine and their pharmacological activity has also been explored through literature search...
October 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/29096375/solid-lipid-nanoparticles-for-delivery-of-andrographolide-across-the-blood-brain-barrier-in-vitro-and-in-vivo-evaluation
#6
Giulia Graverini, Vieri Piazzini, Elisa Landucci, Daniela Pantano, Pamela Nardiello, Fiorella Casamenti, Domenico E Pellegrini-Giampietro, Anna Rita Bilia, Maria Camilla Bergonzi
Andrographolide is a major diterpenoid of Andrographis paniculata and possesses several biological activities, including protection against oxidative stress mediated neurotoxicity, inflammation-mediated neurodegeneration, and cerebral ischemia. However, this molecule shows low bioavailability, poor water solubility, and high chemical and metabolic instability. The present study reports preparation of solid lipid nanoparticles (SLN) to deliver andrographolide (AG) into the brain. SLN were prepared using Compritol 888 ATO as solid lipid and Brij 78 as surfactant and applying emulsion/evaporation/solidifying method as preparative procedure...
October 27, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29080615/antiviral-activity-of-five-asian-medicinal-pant-crude-extracts-against-highly-pathogenic-h5n1-avian-influenza-virus
#7
Benjaporn Sornpet, Teerapong Potha, Yingmanee Tragoolpua, Kidsadagon Pringproa
OBJECTIVE: To study the antiviral properties of the five Asian medicinal plants against in vitro infection by the highly pathogenic avian influenza virus (H5N1). METHODS: Crude extracts of Andrographis paniculata, Curcuma longa (C. longa), Gynostemma pentaphyllum, Kaempferia parviflora (K. parviflora), and Psidium guajava obtained by both water and ethanol extractions were investigated for their cytotoxicity in the Madin-Darby canine kidney cells. Thereafter, they were investigated in vitro for antiviral activity and cytokine response upon H5N1 virus infection...
September 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/29071789/online-hyphenation-of-extraction-sephadex-lh-20-column-chromatography-and-high-speed-counter-current-chromatography-a-highly-efficient-strategy-for-the-preparative-separation-of-andrographolide-from-andrographis-paniculata-in-a-single-step
#8
Ying-Qi Zhang, Shan-Shan Wang, Chao Han, Jin-Fang Xu, Jian-Guang Luo, Ling-Yi Kong
A novel isolation strategy, on-line hyphenation of ultrasonic extraction, Sephadex LH-20 column chromatography combined with high-speed counter-current chromatography, was developed for pure compounds extraction and purification. Andrographolide from Andrographis paniculata was achieved only in a single step purification protocol via the present strategy. The crude powder was ultrasonic extracted and extraction was pumped into Sephadex LH-20 column directly to cut the non-target fractions followed by the second dimensional high-speed counter-current chromatography, hyphenated by a six-port valve equipped at the post-end of Sephadex LH-20 column, for the final purification...
October 26, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/29042302/attenuation-of-pseudomonas-aeruginosa-quorum-sensing-virulence-and-biofilm-formation-by-extracts-of-andrographis-paniculata
#9
Malabika Banerjee, Soumitra Moulick, Kunal Kumar Bhattacharya, Debaprasad Parai, Subrata Chattopadhyay, Samir Kumar Mukherjee
Quorum-sensing (QS) is known to play an essential role in regulation of virulence factors and toxins during Pseudomonas aeruginosa infection which may frequently cause antibiotic resistance and hostile outcomes of inflammatory injury. Therefore, it is an urgent need to search for a novel agent with low risk of resistance development that can target QS and inflammatory damage prevention as well. Andrographis paniculata, a herbaceous plant under the family Acanthaceae, native to Asian countries and also cultivated in Scandinavia and some parts of Europe, has a strong traditional usage with its known antibacterial, anti-inflammatory, antipyretic, antiviral and antioxidant properties...
October 14, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29034193/comparative-study-of-herbal-plants-on-the-phenolic-and-flavonoid-content-antioxidant-activities-and-toxicity-on-cells-and-zebrafish-embryo
#10
Hassan Fahmi Ismail, Zanariah Hashim, Wong Tet Soon, Nur Syukriah Ab Rahman, Ain Nabihah Zainudin, Fadzilah Adibah Abdul Majid
Natural antioxidants derived from plants have shown a tremendous inhibitory effect on free radicals in actively metabolizing cells. Overproduction of free radicals increases the risk factor of chronic diseases associated with diabetes, cancer, arthritis and cardiovascular disease. Andrographis paniculata, Cinnamon zeylanicum, Curcuma xanthorrhiza, Eugenia polyantha and Orthosiphon stamineus are ethnomedicinal plants used in the Asian region to treat various illnesses from a common fever to metabolic disease...
October 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/28994531/-cloning-subcellular-localization-and-heterologous-expression-of-apnac1-gene-from-andrographis-paniculata
#11
Jian Wang, Meng-Die Qi, Juan Guo, Ye Shen, Hui-Xin Lin, Lu-Qi Huang
Andrographis paniculata is widely used as medicinal herb in China for a long time and andrographolide is its main medicinal constituent. To investigate the underlying andrographolide biosynthesis mechanisms, RNA-seq for A. paniculata leaves with MeJA treatment was performed. In A. paniculata transcriptomic data, the expression pattern of one member of NAC transcription factor family (ApNAC1) matched with andrographolide accumulation. The coding sequence of ApNAC1 was cloned by RT-PCR, and GenBank accession number was KY196416...
March 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28959670/is-andrographis-paniculata-extract-and-andrographolide-anaphylactic
#12
Edwin Jothie Richard, Sasikumar Murugan, Bharathi Bethapudi, Ramanaiah Illuri, Deepak Mundkinajeddu, Chandrasekaran Chinampudur Velusami
Andrographis paniculata, "King of bitters" is a popularly known medicinal plant extensively used in many parts of the world for treatment of various diseases. Since recent past, anaphylactic/allergic type adverse events were reported upon A. paniculata usage, the study aimed to evaluate the anaphylactic and anaphylactoid potential of A. paniculata extract and andrographolide (a major phytoactive of A. paniculata). The anaphylactic potential was evaluated using active systemic anaphylaxis (ASA) assay in guinea pigs...
2017: Toxicology Reports
https://www.readbyqxmd.com/read/28948486/efficacy-and-tolerability-of-phytomedicines-in-multiple-sclerosis-patients-a-review
#13
REVIEW
Mohammad Hosein Farzaei, Zahra Shahpiri, Roodabeh Bahramsoltani, Marjan Moghaddam Nia, Fariba Najafi, Roja Rahimi
Multiple sclerosis (MS) is a chronic inflammatory and demyelinating disorder of the central nervous system (CNS) that can cause cognition, mobility, and sensory impairments. It is considered one of the most common non-traumatic causes of disability in the world. The aim of the present article was to review the clinical evidence related to medicinal plants in the management of MS symptoms. Electronic databases, including the Cochrane Library, Pubmed, and Scopus, were searched for entries from 1966 to February 2017...
October 2017: CNS Drugs
https://www.readbyqxmd.com/read/28918484/drug-herb-interactions-in-the-elderly-patient-with-ibd-a-growing-concern
#14
REVIEW
Haider Rahman, Marina Kim, Galen Leung, Jesse A Green, Seymour Katz
Inflammatory bowel disease (IBD), which includes conditions such as Crohn's disease and ulcerative colitis, is becoming more prevalent with the elderly being the fastest growing group. Parallel to this, there is an increasing interest in the use of complementary and alternative medicine (CAM). Nearly half of patients with IBD have used CAM at one time. The elderly patients, however, are burdened by comorbid conditions, polypharmacy, and altered functional status. With increasing use of complementary and alternative medicine in our elderly patients with IBD, it is vital for the provider to provide counsel on drug-herb potential interactions...
December 2017: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/28916855/green-approach-for-synthesis-of-zinc-oxide-nanoparticles-from-andrographis-paniculata-leaf-extract-and-evaluation-of-their-antioxidant-anti-diabetic-and-anti-inflammatory-activities
#15
Govindasamy Rajakumar, Muthu Thiruvengadam, Govindarasu Mydhili, Thandapani Gomathi, Ill-Min Chung
Bio-mediated synthesis of zinc oxide nanoparticles (ZnO NPs) was carried out by utilizing the reducing and capping potential of Andrographis paniculata leaf extract. The capped ZnO NPs were characterized using UV-Vis, XRD, FTIR, SEM, TEM and SAED analyses. FTIR analysis suggested the role of phenolic compounds, terpenoids, and proteins of A. paniculata leaf extract, in nucleation and stability of ZnO NPs. XRD pattern compared with the standard confirmed spectrum of zinc oxide particles formed in the present experiments were in the form of nanocrystals, as evidenced by the peaks at 2θ values...
September 15, 2017: Bioprocess and Biosystems Engineering
https://www.readbyqxmd.com/read/28898904/the-protective-effect-of-the-ethanol-leaf-extract-of-andrographis-paniculata-on-cisplatin-induced-acute-kidney-injury-in-rats-through-nrf2-kim-1-signalling-pathway
#16
Bisi Olajumoke Adeoye, Ebunoluwa Racheal Asenuga, Ademola Adetokunbo Oyagbemi, Temidayo Olutayo Omobowale, Adeolu A Adedapo
The ethanol leaf extract of Andrographis paniculata was used to ameliorate the renal toxicity induced by cisplatin in 28 rats divided into four groups of seven rats per group. Group A received normal saline for the duration of the experiment. Group B animals were treated with cisplatin (10 mg/kg i.p) on day 1 and 3 days after received normal saline for the next 7 days while groups C and D animals also received 10 mg/kg dose of cisplatin on day 1 but after 3 days were then respectively treated with 200 and 400 mg/kg doses of the extract of Andrographis paniculata for the remaining 7 days through oral administration...
September 12, 2017: Drug Research
https://www.readbyqxmd.com/read/28889969/andrographolide-inhibits-influenza-a-virus-induced-inflammation-in-a-murine-model-through-nf-%C3%AE%C2%BAb-and-jak-stat-signaling-pathway
#17
Yi Ding, Lizhu Chen, Wenjiao Wu, Jie Yang, Zifeng Yang, Shuwen Liu
Influenza viruses, the main cause of respiratory tract diseases, cause high morbidity and mortality in humans. Excessive inflammation in the lungs is proposed to be a hallmark for the severe influenza virus infection, especially influenza A virus infection. Strategies against inflammation induced by influenza A virus infection could be a potential anti-influenza therapy. Here, lethal dose of mouse-adapted H1N1 strain PR8A/PR/8/34 was inoculated C57BL/6 mice to detect the anti-influenza activity of andrographolide, the active component of traditional Chinese medicinal herb Andrographis paniculata, with or without influenza virus entry inhibitor CL-385319...
September 7, 2017: Microbes and Infection
https://www.readbyqxmd.com/read/28878680/andrographolide-a-new-hope-in-the-prevention-and-treatment-of-metabolic-syndrome
#18
REVIEW
Muhammad T Islam
Recently, the use of plant-derived medicines is increasing interest in the prevention and treatment of a variety of disorders including metabolic syndromes. Metabolic syndrome is one of the major risk factors for cardiovascular diseases (CVDs) and incidence of mortality worldwide. Scientific evidence suggests that Andrographis paniculata and its derived components, especially andrographolide (AGL) and its analogs/derivatives have a broad spectrum of biological activities. This review aims to sketch the activity of AGL and its analogs/derivatives against the components of metabolic syndromes such as diabetes, hyperlipidemia, hypertension, and obesity...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28870345/mechanism-of-antagonistic-effects-of-andrographis-paniculata-methanolic-extract-against-staphylococcus-aureus
#19
Roslinah Mohamad Hussain, Zayan Nabilah Rasyidah Abd Razak, Wan Mazlina Md Saad, Maimunah Mustakim
OBJECTIVE: To investigate the effects of Andrographis paniculata (Burm.f.) Wall. Ex Nees (A. paniculata) on expressions and activities of catalase, superoxide dismutase and alkylhydroperoxide reductase C in Staphylococcus aureus (S. aureus) with respect to its survival in vitro. METHODS: Antioxidative property of methanolic leaves extract of A. paniculata (0.06 mg/mL). Minimum inhibitory concentration (MIC) was determined by its ability to reduce hydrogen peroxide (H2O2) toxicity against S...
July 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28863380/effect-of-two-andrographolide-derivatives-on-cellular-and-rodent-models-of-non-alcoholic-fatty-liver-disease
#20
Erenius Toppo, S Sylvester Darvin, S Esakkimuthu, Mahesh Kumar Nayak, K Balakrishna, K Sivasankaran, P Pandikumar, S Ignacimuthu, N A Al-Dhabi
The prevalence of Non-Alcoholic Fatty Liver Disease (NAFLD) is increasing and there is an increasing interest in natural products to treat NAFLD. This study aimed to evaluate the hepatoprotective effect of andrographolide and two of its derivatives; in one the OH group at C-14 was removed and in the other OH groups at C-3 and C-19 were protected. Andrographolide (AN) was isolated from the aerial parts of Andrographis paniculata Wall. Isoandrographolide (IAN) and 3,19-acetonylidene andrographolide (ANA) were derivatized from AN...
November 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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