keyword
https://read.qxmd.com/read/37976725/psoralea-corylifolia-formula-extract-loaded-silk-fibroin-polycaprolactone-fibrous-membrane-for-the-treatment-of-colorectal-cancer
#21
JOURNAL ARTICLE
Yusheng Feng, Zhifen Han, Chong Chen, Xuchen Wang, Jing Liu, Yousef Khan, Maobin Xie, Yufeng Chen, Yue Zhang, Gang Li
Intestinal obstructions caused by intestinal tumors pose life-threatening risks to patients. Adjuvant treatment using intestinal stents carrying drug loaded membranes has the advantages of timely relief of intestinal obstruction, as well as effective inhibition of tumor progression. The present work is to develop an intestinal stent loaded with a combination of traditional Chinese medicines capable of good biocompatibility, degradability, sustained drug release and anti-tumor properties. The drug combination extract was obtained from Psoralea corylifolia formula (PCF) and then was loaded into silk fibroin (SF)/polycaprolactone (PCL) fibrous membranes using emulsion electrospinning technology...
November 7, 2023: Colloids and Surfaces. B, Biointerfaces
https://read.qxmd.com/read/37918280/identification-of-pik3r5-as-a-hub-in-septic-myocardial-injury-and-the-cardioprotective-effects-of-psoralidin
#22
JOURNAL ARTICLE
Xue Wang, Zhenxing Liang, Qiong Liu, Xingyan Ye, Xue Wu, Chao Deng, Lin Zhao, Chenxi Lu, Zhenye Qiu, Yu Yao, Yang Yang, Xuezeng Xu
BACKGROUND: Myocardial injury is a severe complication of sepsis, resulting in substantial morbidity and mortality. Psoralidin (PSO), derived from the seeds of Psoralea corylifolia L., has garnered considerable attention due to its potent pharmacological effects, including anti-inflammatory and antibacterial effects. PURPOSE: Our previous work conducted affirmed that PSO has a protective effect on sepsis and septic myocardial injury, however the specific molecular mechanisms need further clarification...
October 17, 2023: Phytomedicine
https://read.qxmd.com/read/37867998/a-gene-expression-profile-based-approach-to-screen-the-occurrence-and-predisposed-host-characteristics-of-drug-induced-liver-injury-a-case-study-of-psoralea-corylifolia-linn
#23
JOURNAL ARTICLE
Ming-Liang Zhang, Wei-Xia Li, Xiao-Yan Wang, Hui Zhang, Ya-Li Wu, Liu-Qing Yang, Xiao-Fei Chen, Shu-Qi Zhang, Yu-Long Chen, Ke-Ran Feng, Jin-Fa Tang
Drug-induced liver injury (DILI) is one of the most common causes of a drug being withdrawn, and identifying the culprit drugs and the host factors at risk of causing DILI has become a current challenge. Recent studies have found that immune status plays a considerable role in the development of DILI. In this study, DILI-related differentially expressed genes mediated by immunoinflammatory cytokines were obtained from the Gene Expression Omnibus (GEO) database to predict the occurrence of DILI (named the DILI predictive gene set, DILI_PGS), and the predictability of the DILI_PGS was verified using the Connectivity Map (CMap) and LiverTox platforms...
2023: Frontiers in Chemistry
https://read.qxmd.com/read/37866487/bavachin-combined-with-epimedin-b-induce-idiosyncratic-liver-injury-under-immunological-stress-conditions
#24
JOURNAL ARTICLE
Mengmeng Lin, Yingying Li, Bo Cao, Jing Xu, Yujun Zhang, Guohui Li, Xiaohe Xiao, Chunyu Li
Reports on Chinese patent medicines preparations containing Epimedii Folium (EF) and Psoraleae Fructus (PF) resulting in idiosyncratic drug-induced liver injury (IDILI) have received widespread attention. Previous studies have shown that bavachin and epimedin B-two active ingredients derived from both EF and PF-are potential components associated with IDILI, but the underlying mechanism remains unclear. We evaluated bavachin and epimedin B-induced IDILI under TNF-α-mediated immunological stress conditions and generated liver lipid metabolism profiles using lipidomics and multivariate statistical analysis...
October 20, 2023: Chemico-biological Interactions
https://read.qxmd.com/read/37857572/bakuchiol-modulates-acetylcholine-synthesis-and-alleviates-a%C3%AE-proteotoxicity
#25
JOURNAL ARTICLE
Sachin Ranjan, Shalini Trivedi, Shruti Sharma, Salman Khan, Rakesh Pandey
The transmission of acetylcholine (ACh) is critically important for memory, learning, and behaviour. The most promising approaches for the treatment of cholinergic dysfunction involve the enhancement of ACh via nootropic phytomolecules. In the same line, the present study identifies the active molecule Bakuchiol derived from Psoralea corylifolia . Bakuchiol demonstrated significant elevation of ACh transmission, reduction of reactive oxygen species (ROS) levels, and extension of lifespan. Further investigation indicated that modulation of mRNA expression of genes encoding choline transporter, choline acetyltransferase, and acetylcholine transporter as possible effectors of amassed neural transmission...
October 19, 2023: Natural Product Research
https://read.qxmd.com/read/37827069/lipidomics-reveals-the-lipid-metabolism-disorders-in-fructus-psoraleae-induced-hepatotoxicity-in-rats-with-kidney-yin-deficiency-syndrome
#26
JOURNAL ARTICLE
Xiao-Yan Wu, Li-Juan Xie, Jun-Jie He, Xing-Xu Yan, Fang-Fang Zhang, Yan-Yan Xu, Yu-Bo Li
Fructus Psoraleae (FP), one of the important traditional Chinese medicines, is widely used in clinic and has been reported to be hepatotoxic. However, there is no report on the mechanism of FP-induced hepatotoxicity based on the theory of You Gu Wu Yun. In this study, plasma samples of rats with different kidney deficiency syndromes were investigated using a lipidomics approach based on UPLC/Q-TOF-MS technique. Firstly, multivariate statistical analysis, VIP value test, statistical test and other methods were used to find the lipid metabolites in the two syndrome model groups that were different from the normal group...
September 26, 2023: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://read.qxmd.com/read/37816590/exploring-quality-evaluation-markers-of-fructus-psoraleae-based-on-chemometric-analysis-integrated-with-network-pharmacology
#27
JOURNAL ARTICLE
Yuting Zhao, Junfeng Guo, Qixuan Mu, Ruojin Liu, Hui Liu, Yanyan Xu, Yubo Li
INTRODUCTION: Fructus Psoraleae (FP) is a well-known traditional Chinese medicine for the treatment of osteoporosis. However, major quality differences were witnessed owing to its various origins, thus influencing its safety and efficacy. OBJECTIVES: The study aimed to evaluate the quality of FP from different origins and predict its quality evaluation markers. METHODS: Ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry was employed for tentative characterisation of the constituents in 10 batches of FP, followed by the utilisation of multivariate statistical analysis methods including principal component analysis and orthogonal partial least squares discriminant analysis for quality evaluation...
October 10, 2023: Phytochemical Analysis: PCA
https://read.qxmd.com/read/37802872/-effect-of-28-day-administration-of-psoraleae-fructus-water-extract-on-early-liver-injury-in-rats
#28
JOURNAL ARTICLE
Bo Xu, Guang-Tao Yao, Jun Xie, Lei Ran, Xin-Yu A, Lian-Bo Xiao
This study aims to investigate the hepatotoxicity of Psoraleae Fructus water extract and the underlying mechanism in rats. Forty-eight rats were randomly assigned into four groups: a blank group and low-(BZGL, 6.25 g·kg~(-1)), medium-(BGZM, 12.5 g·kg~(-1)), and high-dose(BGZH, 25 g·kg~(-1)) Psoraleae Fructus water extract groups. The rats were treated for 28 days, and toxicity and mortality were observed daily. After 28 days, the rats were sacrificed, and the body weight, liver index, and liver-to-brain ratio were calculated...
August 2023: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://read.qxmd.com/read/37802771/-serum-metabolomics-study-of-psoraleae-fructus-in-improving-learning-and-memory-ability-of-app-ps1-mice
#29
JOURNAL ARTICLE
Jia-Ming Gu, Hui Xue, Ao Xue, Jing Jiang, Fang Geng, Ji-Hui Zhao, Bo Yang, Ning Zhang
This study aimed to investigate the mechanism of Psoraleae Fructus in improving the learning and memory ability of APP/PS1 mice by serum metabolomics, screen the differential metabolites of Psoraleae Fructus on APP/PS1 mice, and reveal its influence on the metabolic pathway of APP/PS1 mice. Thirty 3-month-old APP/PS1 mice were randomly divided into a model group and a Psoraleae Fructus extract group, and another 15 C57BL/6 mice of the same age were assigned to the blank group. The learning and memory ability of mice was evaluated by the Morris water maze and novel object recognition tests, and metabolomics was used to analyze the metabolites in mouse serum...
August 2023: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://read.qxmd.com/read/37752710/phytochemical-and-pharmacological-aspects-of-psoralen-a-bioactive-furanocoumarin-from-psoralea-corylifolia-linn
#30
JOURNAL ARTICLE
Nancy Tripathi, Nivedita Bhardwaj, Sanjay Kumar, Shreyans Kumar Jain
Since long ago, medicinal plants have played a vital role in drug discovery. Being blessed and rich in chemovars with diverse scaffolds, they have unique characteristics of evolving based on the need. The World Health Organization also mentions that medicinal plants remain at the center for meeting primary healthcare needs as the population relies on them. The plant-derived natural products have remained an attractive choice for drug development owing to their specific biological functions relevant to human health and also the high degree of potency and specificity they offer...
September 26, 2023: Chemistry & Biodiversity
https://read.qxmd.com/read/37748667/bavachin-induces-liver-injury-and-cell-apoptosis-by-targeting-wnt-%C3%AE-catenin-drp1-signaling-pathway-mediated-mitochondrial-dysfunction
#31
JOURNAL ARTICLE
Ying Yang, Wei Zhou, Yihao Wang, Yunxuan Ge, Zheng Fan, Qingquan Liu, Yue Gao
Psraleae Fructus (PF) is a well-known traditional Chinese medicine in China. While numerous liver injury reports caused by PF limits its clinical application. Bavachin, a flavonoid compound isolated from the fruits of Psoralea corylifolia L., has been validated to induce direct apoptosis in hepatocytes and liver tissues in our previous studies. However, the subcellular mechanisms of bavachin induced liver injury is still elusive. Here, utilizing 6-week-old C57BL/6J mice and human embryonic hepatocytes (L02 cells), we report that bavachin activates dynamic-related protein 1 (DRP1) mediated excess mitochondrial fission and endoplasmic reticulum (ER) stress related apoptosis via Wnt/β-catenin signaling pathway...
September 23, 2023: Toxicology Letters
https://read.qxmd.com/read/37685978/psoralen-alleviates-renal-fibrosis-by-attenuating-inflammasome-dependent-nlrp3-activation-and-epithelial-mesenchymal-transition-in-a-mouse-unilateral-ureteral-obstruction-model
#32
JOURNAL ARTICLE
Tae Won Lee, Eunjin Bae, Jin Hyun Kim, Myeong Hee Jung, Dong Jun Park
The role of psoralen (PS), a major active component extracted from Psoralea corylifolia L. seed, in renal fibrosis is still unclear. Thus, the objective of this study was to evaluate the effects of PS on the development and progression of renal fibrosis induced by unilateral ureteral obstruction (UUO) in a mouse model. Mice were divided into four groups: PS (20 mg/kg, i.g., n = 5), PS + sham ( n = 5), UUO ( n = 10), and PS + UUO ( n = 10). PS was intragastrically administered 24 h before UUO and continued afterwards for 7 days...
August 24, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37660943/mechanistic-study-of-cytochrome-p450-enzyme-mediated-cytotoxicity-of-psoralen-and-isopsoralen
#33
JOURNAL ARTICLE
Shuaishuai Chen, Weiyu Guo, Huan Liu, Jiang Zheng, Dingyan Lu, Jia Sun, Chun Li, Chunhua Liu, Yonglin Wang, Yong Huang, Wen Liu, Yongjun Li, Ting Liu
Psoralen and isopsoralen are the major components responsible for Psoraleae Fructus-induced hepatotoxicity. This study explored the role of metabolic activation by cytochrome P450 (CYP) enzymes in psoralen- and isopsoralen-induced cytotoxicity and its potential mechanisms. Inhibitors of CYP1A2, 2C9, 2C19, 2D6, 2E1, and 3A4 were used to screen specific CYP enzymes responsible for the metabolic activation of psoralen and isopsoralen in mouse primary hepatocytes, which was verified using the corresponding transfected cell lines...
September 1, 2023: Food and Chemical Toxicology
https://read.qxmd.com/read/37598872/4-hydroxylonchocarpin-and-corylifol-a-the-potential-hepatotoxic-components-of-psoralea-corylifolia-l
#34
JOURNAL ARTICLE
Linqi Ouyang, Zhiqiang Fan, Yang He, Long Tan, Guoyan Deng, Qin He, Yiran He, Ting Ouyang, Congjie Li, Qin Zhang, Hongyu Liu, Yajie Zuo
Psoralea corylifolia L. (P. corylifolia) has attracted increasing attention because of its potential hepatotoxicity. In this study, we used network analysis (toxic component and hepatotoxic target prediction, proteinprotein interaction, GO enrichment analysis, KEGG pathway analysis, and molecular docking) to predict the components and mechanism of P. corylifolia-induced hepatotoxicity and then selected 4-hydroxylonchocarpin and corylifol A for experimental verification. HepG2 cells were treated with low, medium, and high concentrations of 4-hydroxylonchocarpin or corylifol A...
August 18, 2023: Toxicology Letters
https://read.qxmd.com/read/37592331/yin-yang-associated-differential-responses-to-psoralea-corylifolia-linn-in-rat-models-an-integrated-metabolomics-and-transcriptomics-study
#35
JOURNAL ARTICLE
Ming-Liang Zhang, Xu Zhao, Wei-Xia Li, Xiao-Yan Wang, Ming Niu, Hui Zhang, Yu-Long Chen, De-Xin Kong, Yuan Gao, Yu-Ming Guo, Zhao-Fang Bai, Yan-Ling Zhao, Jin-Fa Tang, Xiao-He Xiao
ETHNOPHARMACOLOGICAL RELEVANCE: Psoralea corylifolia Linn. (BGZ) is a commonly used traditional Chinese medicine (TCM) for the treatment of kidney-yang deficiency syndrome (Yangsyn ) with good curative effect and security. However, BGZ was also reported to induce liver injury in recent years. According to TCM theory, taking BGZ may induce a series of adverse reactions in patients with kidney-yin deficiency syndrome (Yinsyn ), which suggests that BGZ-induced liver damage may be related to its unreasonable clinical use...
August 17, 2023: Chinese Medicine
https://read.qxmd.com/read/37586115/undesirable-er-stress-induced-by-bavachin-contributed-to-follicular-atresia-in-zebrafish-ovary
#36
JOURNAL ARTICLE
Cong-Shu Huang, Hui-Fang Deng, Lei Zhou, Pan Shen, Yu-Hao Ni, Ning-Ning Wang, Gao-Fu Li, Lan-Xin Yue, Yong-Qiang Zhou, Wei Zhou, Yue Gao
Fructus psoraleae (FP) is a commonly used herb with potential reproductive toxicity. Bavachin (BV), one of essential active ingredients of FP, was found to exhibit estrogenic activity, but its effect on female reproductive system remains unknown. In this study, the impact of BV on the female zebrafish reproductive system and underlying molecular mechanism were determined in vivo and ex vivo. The results showed that BV could accumulate in zebrafish ovary, leading to obvious follicular atresia and increase in gonadal index and vitellogenin content...
August 14, 2023: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/37577386/a-scd1-mediated-metabolic-alteration-participates-in-liver-responses-to-low-dose-bavachin
#37
JOURNAL ARTICLE
Pan Shen, Zhi-Jie Bai, Lei Zhou, Ning-Ning Wang, Zhe-Xin Ni, De-Zhi Sun, Cong-Shu Huang, Yang-Yi Hu, Cheng-Rong Xiao, Wei Zhou, Bo-Li Zhang, Yue Gao
Hepatotoxicity induced by bioactive constituents in traditional Chinese medicines or herbs, such as bavachin (BV) in Fructus Psoraleae, has a prolonged latency to overt drug-induced liver injury in the clinic. Several studies have described BV-induced liver damage and underlying toxicity mechanisms, but little attention has been paid to the deciphering of organisms or cellular responses to BV at no-observed-adverse-effect level, and the underlying molecular mechanisms and specific indicators are also lacking during the asymptomatic phase, making it much harder for early recognition of hepatotoxicity...
July 2023: Journal of Pharmaceutical Analysis
https://read.qxmd.com/read/37560226/network-pharmacology-of-the-yigu-decoction-empirical-formula-on-the-treatment-of-knee-osteoarthritis
#38
JOURNAL ARTICLE
Jiaxin Wang, Chengyiye Ren, Yuepeng Xie
OBJECTIVE: To investigate the mechanism of the Yigu Decoction empirical formula in the treatment of knee osteoarthritis (KOA) using network pharmacology and molecular docking methods. METHODS: The active ingredients and targets of Yigu Decoction were screened using the TCMSP database. Relevant targets were predicted using several databases. A "drug-component-target-disease" network was constructed using Cytoscape software. A protein-protein interaction network was constructed using the STRING database...
2023: American Journal of Translational Research
https://read.qxmd.com/read/37508388/diversity-genomics-and-symbiotic-characteristics-of-sinorhizobia-that-nodulate-desmanthus-spp-in-northwest-argentina
#39
JOURNAL ARTICLE
Nicolás Emilio Zuber, Laura Viviana Fornasero, Sofía Agostina Erdozain Bagolín, Mauricio Javier Lozano, Juan Sanjuán, María Florencia Del Papa, Antonio Lagares
Desmanthus spp. are legumes with the ability to associate with diverse α-proteobacteria-a microsymbiont-in order to establish nitrogen-fixing root nodules. A previous investigation from our laboratory revealed that the main bacteria associated with Desmanthus paspalaceus in symbiosis in central Argentina (Province of Santa Fe) were quite diverse and belonged to the genera Rhizobium and Mesorhizobium . To achieve a more extensive view of the local microsymbionts associated with Desmanthus spp., we sampled three different sites in Jujuy and Salta, in northwest Argentina...
July 4, 2023: Biology
https://read.qxmd.com/read/37464553/a-practical-method-for-rapid-discrimination-of-constituents-in-psoraleae-fructus-by-uplc-q-orbitrap-ms
#40
JOURNAL ARTICLE
Yanyan Chen, Luhuan Tang, Mengru Wu, Lexin Shu, Yanyan Xu, Yaqi Yao, Yubo Li
Psoraleae Fructus (PF) is one of the most frequently used traditional Chinese medicine, which has good efficacy in warming kidney to activate yang, promoting inspiration to relieve asthma and warming spleen to stop diarrhea. However, the chemical composition of PF is complex, which makes it difficult to determine its active and toxic components. In order to rapidly classify and identify the chemical components of the extracts from PF, this research was processed with CNKI, PubMed, and PubChem databases and data post-processing technique basing on ultrahigh performance liquid chromatography quadrupole orbitrap mass spectrometry (UPLC-Q-Orbitrap MS) technique...
August 2023: Journal of Mass Spectrometry: JMS
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