Zhuo Shi, Jin-Chao Pan, Yi Ru, Ning-Ning Shen, Yu-Fu Liu, Cheng Zhang, Xiang-Jun Wu, Fang-Yang Li, Jia-Lu Cui, Chun-Qi Yang, Jun-Ling Yang, Mao-Xing Li, Cheng-Rong Xiao, Zeng-Chun Ma, Chuan Li, Yu-Guang Wang, Yue Gao
ETHNOPHARMACOLOGICAL RELEVANCE: Psoraleae Fructus (PF), the dried fruit of Psoralea corylifolia L., is a commonly used traditional medicine that has contributed to the treatment of orthopedic diseases for thousands of years in China. However, recent PF-related liver injury reports have drawn widespread attention regarding its potential hepatotoxicity risks. AIM OF THE STUDY: This study was aimed to evaluate the long-term efficacy and chronic toxicity of PF using a 26-week administration experiment on rats in order to simulate the clinical usage situation...
February 29, 2024: Journal of Ethnopharmacology