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Psoralea

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https://www.readbyqxmd.com/read/28069007/the-benzopyrone-biochanin-a-as-a-reversible-competitive-and-selective-monoamine-oxidase-b-inhibitor
#1
Najla O Zarmouh, Suresh K Eyunni, Karam F A Soliman
BACKGROUND: Monoamine oxidase-B (MAO-B) inhibitors are widely used in the treatment of Parkinson's disease. They increase vital monoamine neurotransmitters in the brain. However, there is a need for safer natural reversible MAO inhibitors with MAO-B selectivity. Our previous studies showed that Psoralea corylifolia seeds (PCS) extract contains compounds that inhibit monoamine oxidase-B. METHODS: In this study, six of PCS constituents sharing a benzopyrone structure were investigated...
January 10, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28060896/isobavachalcone-attenuates-mptp-induced-parkinson-s-disease-in-mice-by-inhibition-of-microglial-activation-through-nf-%C3%AE%C2%BAb-pathway
#2
Haoran Jing, Shaoxia Wang, Min Wang, Wenliang Fu, Chao Zhang, Donggang Xu
Parkinson's disease (PD) is a complex multi-system and age-related neurodegenerative disorder. The intervention targeting neuroinflammation in PD patients is one effective strategy to slow down or inhibit disease progression. Microglia-mediated inflammatory response plays an important role in Parkinson's, Alzheimer's and other cerebral diseases. Isobavachalcone is a main component of Chinese herb medicine Psoralea corylifolia, which function includes immunoregulation, anti-oxidation and the regulation of β-amyloid (Aβ42) deposited in hippocampus in Alzheimer's patients...
2017: PloS One
https://www.readbyqxmd.com/read/27994628/the-extract-of-fructus-psoraleae-promotes-viability-and-cartilaginous-formation-of-rat-chondrocytes-in-vitro
#3
Xin Pan, Kang Xu, Xuefeng Qiu, Wen Zhao, Dong Wang, Li Yang
This study aimed to investigate the extract components of FP on rat chondrocyte function and cartilaginous formation in vitro. Petroleum ether extract (P-e) of FP extract components was selected to treat Sprague-Dawley rat chondrocytes. Cell viability was tested with different concentrations (0.1, 1, 10, and 100 μg/mL) of P-e treatment. Concentrations of 0.1 and 1 μg/mL P-e conditioned culture mediums were used for treating chondrocytes in experiments. Cell proliferation was measured via DNA incorporation assay...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27965579/in-vitro-anti-viral-activity-of-psoraleae-semen-water-extract-against-influenza-a-viruses
#4
Jang-Gi Choi, Young-Hee Jin, Ji-Hye Kim, Tae Woo Oh, Nam-Hui Yim, Won-Kyung Cho, Jin Yeul Ma
Influenza causes respiratory infections and poses health risks to humans and animals; its effects are complicated by increasing resistance to existing anti-influenza viral agents. Therefore, novel therapeutic approaches against influenza virus infection are required. Psoraleae semen has been widely used in traditional medicine in Korea, Taiwan, China, and Japan for treating and preventing various diseases. In this study, we examined the anti-viral activities and mechanism of action of the water extract of Psoraleae semen (WPS) using RAW 264...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27956922/phytochemical-and-pharmacological-studies-on-the-genus-psoralea-a-mini-review
#5
REVIEW
Cong-Cong Li, Teng-Long Wang, Zhong-Qun Zhang, Wen-Qiang Yang, Yue-Fei Wang, Xin Chai, Chun-Hua Wang, Zheng Li
The genus Psoralea, which belongs to the family Fabaceae, comprises ca. 130 species distributed all over the world, and some of the plants are used as folk medicine to treat various diseases. Psoralea corylifolia is a typical example, whose seeds have been widely used in many traditional Chinese medicine formulas for the treatment of various diseases such as leucoderma and other skin diseases, cardiovascular diseases, nephritis, osteoporosis, and cancer. So, the chemical and pharmacological studies on this genus were performed in the past decades...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27920496/fabrication-of-anti-vitiligo-ointment-containing-psoralea-corylifolia-in-vitro-and-in-vivo-characterization
#6
Irshad Hussain, Nisar Hussain, Abdul Manan, Abdur Rashid, Barkat Khan, Sattar Bakhsh
BACKGROUND: Vitiligo is a repugnant and odious dermatological malady of the time. It has an detrimental impact on the pigmentation of the human skin as a result of the destruction of cutaneous melanocytes. It affects 1%-2% of the population worldwide. Different therapeutic regimens have been deployed to treat vitiligo, but none of them could stand alone to be stated as a perfect cure. Recently, a change has been observed through novel experimental-designed optimization leading to the development of an anti-vitiligo ointment containing Psoralea corylifolia (PC) seed powder...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/27904813/glycyrrhetinic-acid-might-increase-the-nephrotoxicity-of-bakuchiol-by-inhibiting-cytochrome-p450-isoenzymes
#7
Aifang Li, Nana Ma, Zijing Zhao, Mei Yuan, Hua Li, Qi Wang
BACKGROUND: Licorice, a popular traditional Chinese medicine (TCM), is widely used to moderate the effects (detoxification) of other herbs in TCM and often combined with Fructus Psoraleae. However, the classical TCM book states that Fructus Psoraleae is incompatible with licorice; the mechanism underlying this incompatibility has not been identified. Glycyrrhetinic acid (GA), the active metabolite of licorice, may increase the toxicity of bakuchiol (BAK), the main chemical ingredient in Psoralea corylifolia, by inhibiting its detoxification enzymes CYP450s...
2016: PeerJ
https://www.readbyqxmd.com/read/27899116/the-correlation-between-antimutagenic-activity-and-total-phenolic-content-of-extracts-of-31-plant-species-with-high-antioxidant-activity
#8
Tshepiso Jan Makhafola, Esameldin Elzein Elgorashi, Lyndy Joy McGaw, Luc Verschaeve, Jacobus Nicolaas Eloff
BACKGROUND: Antimutagenic activity of plant extracts is important in the discovery of new, effective cancer preventing agents. There is increasing evidence that cancer and other mutation-related diseases can be prevented by intake of DNA protective agents. The identification of antimutagenic agents present in plants presents an effective strategy to inhibit pathogenic processes resulting from exposure to mutagenic and/or carcinogenic substances present in the environment. There are no reports on the antimutagenic activities of the plant species investigated in this study...
November 29, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27880856/direct-analysis-in-real-time-mass-spectrometry-for-rapid-identification-of-traditional-chinese-medicines-with-coumarins-as-primary-characteristics
#9
Zhiyong Chen, Yuanyuan Yang, Hongxun Tao, Liping Liao, Ye Li, Zijia Zhang
INTRODUCTION: The increasing popularity of traditional Chinese medicines (TCMs) necessitates rapid and reliable methods for controlling their quality. Direct analysis in real-time mass spectrometry (DART-MS) represents a novel approach to analysing TCMs. OBJECTIVE: To develop a quick and reliable method of identifying TCMs with coumarins as primary characteristics. METHODOLOGY: DART-MS coupled with ion trap mass spectrometry was employed to rapidly identify TCMs with coumarins as primary characteristics and to explore the ionisation mechanisms of simple coumarins, furocoumarins and pyranocoumarins in detail...
November 23, 2016: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/27848901/herb-medicines-against-osteoporosis-active-compounds-relevant-biological-mechanisms
#10
Lei Wu, Zhuoyan Ling, Xueqin Feng, Caiping Mao, Zhice Xu
Osteoporosis is one of common bone disorders, affecting millions of people worldwide. Treatments of osteoporosis consist of pharmacotherapy and non-pharmacological interventions, such as mineral supplementation, lifestyle changes, and exercise programs. Due to the minimum side effects and favorable cost-effective therapeutic effects, herbal medicine has been widely applied in clinical practices for more than 2,000 years in China. Of the many traditional formulas reported for treating bone diseases, 4 single herbs namely (1) Herba Epimedii, (2) Rhizoma Drynariae, (3) Fructus Psoraleae, and (4) Cortex Eucommiae, are considered as the featured "Kidney-Yang" tonics, and frequently and effectively applied for preventing and treating osteoporosis...
November 16, 2016: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/27843479/protective-effect-of-psoralea-corylifolia-l-seed-extract-against-palmitate-induced-neuronal-apoptosis-in-pc12-cells
#11
Yunkyoung Lee, Hee-Sook Jun, Yoon Sin Oh
The extract of Psoralea corylifolia seeds (PCE) has been widely used as a herbal medicine because of its beneficial effect on human health. In this study, we investigated the protective effects and molecular mechanisms of PCE on palmitate- (PA-) induced toxicity in PC12 cells, a neuron-like cell line. PCE significantly increased cell viability in PA-treated PC12 cells and showed antiapoptotic effects, as evidenced by decreased expression of cleaved caspase-3, cleaved poly(ADP-ribose) polymerase, and bax protein as well as increased expression of bcl-2 protein...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27771162/multi-locus-sequence-analysis-and-symbiotic-characterization-of-novel-ensifer-strains-nodulating-tephrosia-spp-in-the-indian-thar-desert
#12
Nisha Tak, Esha Awasthi, Garima Bissa, Raju Ram Meghwal, Euan K James, Janet S Sprent, Hukam S Gehlot
Phylogenetically diverse Ensifer strains associated with five species of Tephrosia growing in alkaline soils of semi-arid regions of the Thar Desert were characterized using multi locus sequence analysis. Based on 16S rRNA and four protein-coding housekeeping gene (recA, atpD, glnII and dnaK) sequences, the Tephrosia-Ensifer strains were genetically different from the type strains of Ensifer saheli, Ensifer kostiensis, Ensifer terangae (African origin) and Ensifer psoraleae (Asiatic origin). One strain, Ensifer sp...
December 2016: Systematic and Applied Microbiology
https://www.readbyqxmd.com/read/27670681/anti-cancer-activity-of-psoralea-fructus-through-the-downregulation-of-cyclin-d1-and-cdk4-in-human-colorectal-cancer-cells
#13
Gwang Hun Park, Ji Ho Sung, Hun Min Song, Jin Boo Jeong
BACKGROUND: Psoralea Fructus (PF), the dried and ripe fruit of Psoralea corylifolia exhibits an anti-cancer activity. However, the molecular mechanisms by which PF inhibits the proliferation of cancer cells have not been elucidated in detail. Cyclin D1 and CDK4 are important regulatory proteins in cell growth and are overexpressed in many cancer cells. In this study, we investigated the molecular mechanism of PF on the downregulation of cyclin D1 and CDK4 level. METHODS: Cell growth was evaluated by MTT assay...
September 26, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27587300/psc-afp-from-psoralea-corylifolia-l-overexpressed-in-pichia-pastoris-increases-antimicrobial-activity-and-enhances-disease-resistance-of-transgenic-tobacco
#14
Xiu-Mei Luo, Cheng-Jian Xie, De Wang, Yun-Min Wei, Jie Cai, Shan-Shan Cheng, Xing -Yong Yang, An -Ping Sui
Psc-AFP, isolated from the seeds of Psoralea corylifolia L., is an antimicrobial protein with trypsin inhibitor activity. Its encoding gene was cloned by 3'- rapid amplification of cDNA ends (RACE) combined with Y-shaped adaptor-dependent extension (YADE) method. The gene Psc-AFP encodes a protein of 203 amino acids with a deduced signal peptide of 24 residues. The growth inhibition effect exerted by the heterologously expressed Psc-AFP in Pichia pastoris revealed that the recombinant Psc-AFP inhibited mycelium growth of Aspergillus niger, Rhizoctonia solani, and Alternaria brassicae and conidial germination of Alternaria alternata...
February 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27581277/effects-of-angelicin-on-ovalbumin-ova-induced-airway-inflammation-in-a-mouse-model-of-asthma
#15
Da-Zhen Wei, Xian-Yang Guo, Li-Na Lin, Meng-Xiang Lin, Yu-Qiang Gong, Bin-Yu Ying, Ming-Yuan Huang
Angelicin, a furocoumarin found in Psoralea corylifolia L. fruit, has been reported to have anti-inflammatory activity. The purpose of this study was to determine the protective effects of angelicin on allergic asthma induced by ovalbumin (OVA) in mice. Mice were sensitized to OVA (on days 0 and 14) and challenged with OVA three times (on days 21 to 23). Angelicin (2.5, 5, 10 mg/kg) was given intraperitoneally 1 h before OVA treatment after the initial OVA sensitization. The production of IL-4, IL-5, and IL-13 in BALF and IgE in the serum were measured by ELISA...
December 2016: Inflammation
https://www.readbyqxmd.com/read/27548120/quantitative-analysis-of-psoralea-corylifolia-linne-and-its-neuroprotective-and-anti-neuroinflammatory-effects-in-ht22-hippocampal-cells-and-bv-2-microglia
#16
Yu Jin Kim, Hye-Sun Lim, Jun Lee, Soo-Jin Jeong
The seeds of Psoralea corylifolia L. (P. corylifolia), also known as "Bo-Gol-Zhee" in Korea, are used in a traditional herbal medicine for treating various skin diseases. In the present study, we performed quantitative analyses of the seven standard components of P. corylifolia: psoralen, angelicin, neobavaisoflavone, psoralidin, isobavachalcone, bavachinin, and bakuchiol, using high-performance liquid chromatography. We also investigated the neuroprotective and anti-neuroinflammation effects of P. corylifolia and its standard components in the hippocampal cell line HT22 and microglia cell line BV-2...
August 17, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27347412/qing-e-formula-alleviates-the-aging-process-in-d-galactose-induced-aging-mice
#17
Lin Zhong, Fei Huang, Hailian Shi, Hui Wu, Beibei Zhang, Xiaojun Wu, Xiaohui Wei, Zhengtao Wang
Qing'E formula (QEF) is a clinically used prescription with four ingredients, Eucommiae Cortex, Psoraleae Fructus, Juglandis Semen and Garlic Rhizoma, from the Song dynasty (10th century CE). The present study aimed to investigate the anti-aging effect and mechanisms of QEF on D-galactose-induced aging mice. A mouse subacute aging model was established by subcutaneous injection of D-galactose at the neck consecutively for 8 weeks. Motor activity and memory impairment of the mice were evaluated by the rotarod test and passive avoidance test, respectively...
July 2016: Biomedical Reports
https://www.readbyqxmd.com/read/27341283/natural-products-screening-for-the-identification-of-selective-monoamine-oxidase-b-inhibitors
#18
Najla O Zarmouh, Samia S Messeha, Faisel M Elshami, Karam F A Soliman
AIMS: Monoamine oxidase-B inhibitors (MAO-BIs) are used for the initial therapy of Parkinson's disease. Also, MAO-BIs have shown to be effective neuroprotective agents in several neurodegenerative diseases. However, some concerns exist regarding the long-term use of these compounds. Meanwhile, natural compounds showed potential MAO-B selective inhibitions. To date, few selective natural MAO-BIs have been identified. Therefore, the current study is designed to identify plants with potent and specific MAO-B inhibition...
May 2016: European Journal of Medicinal Plants
https://www.readbyqxmd.com/read/27322374/bioactivity-guided-identification-of-botanical-inhibitors-of-ketohexokinase
#19
MyPhuong T Le, Miguel A Lanaspa, Christina M Cicerchi, Jatinder Rana, Jeffrey D Scholten, Brandi L Hunter, Christopher J Rivard, R Keith Randolph, Richard J Johnson
OBJECTIVE: In developed countries with westernized diets, the excessive consumption of added sugar in beverages and highly refined and processed foods is associated with increased risk for obesity, diabetes, and cardiovascular diseases. As a major constituent of added sugars, fructose has been shown to cause a variety of adverse metabolic effects, such as impaired insulin sensitivity, hypertriglyceridemia, and oxidative stress. Recent studies have shown that ketohexokinase isoform C is the key enzyme responsible in fructose metabolism that drive's fructose's adverse effects...
2016: PloS One
https://www.readbyqxmd.com/read/27314830/identification-of-udp-glucuronosyltransferases-1a1-1a3-and-2b15-as-the-main-contributors-to-glucuronidation-of-bakuchiol-a-natural-biologically-active-compound
#20
Feng Li, Shuai Wang, Danyi Lu, Yifei Wang, Dong Dong, Baojian Wu
1. Bakuchiol, one of the main active compounds of Psoralea corylifolia, possesses a variety of pharmacological activities such as anti-tumor and anti-aging effects. Here, we aimed to characterize the glucuronidation of bakuchiol using human liver microsomes (HLM) and expressed UDP-glucuronosyltransferase (UGT) enzymes. 2. The glucuronide of bakuchiol was confirmed by liquid chromatography-mass spectrometry (LC-MS) and β-glucuronidase hydrolysis assay. Glucuronidation rates and kinetic parameters were derived by enzymatic incubation and model fitting...
June 17, 2016: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
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