HaiShan Li, Wei Deng, JiaMin Yang, YueWei Lin, ShiYin Zhang, ZiXuan Liang, JunChun Chen, MinHua Hu, Teng Liu, GuoYe Mo, Zhen Zhang, DongPing Wang, Peng Gu, YongChao Tang, Kai Yuan, LiangLiang Xu, JiaKe Xu, ShunCong Zhang, YongXian Li
Osteoporosis is a systemic disease characterized by an imbalance in bone homeostasis, where osteoblasts fail to fully compensate for the bone resorption induced by osteoclasts. Corylifol A, a flavonoid extracted from Fructus psoraleae, has been identified as a potential treatment for this condition. Predictions from network pharmacology and molecular docking studies suggest that Corylifol A exhibits strong binding affinity with NFATc1, Nrf2, PI3K, and AKT1. Empirical evidence from in vivo experiments indicates that Corylifol A significantly mitigates systemic bone loss induced by ovariectomy by suppressing both the generation and activation of osteoclasts...
January 19, 2024: Biomedicine & Pharmacotherapy