keyword
MENU ▼
Read by QxMD icon Read
search

Vascular inflammation

keyword
https://www.readbyqxmd.com/read/28635612/consequences-of-lipopolysaccharide-and-n-3-polyunsaturated-fatty-acid-administration-on-aortic-function-of-spontaneously-hypertensive-rats
#1
Barbara Kaprinay, Ruzena Sotnikova, Karel Frimmel, Jakub Krizak, Iveta Bernatova, Jana Navarova, Ludmila Okruhlicova
The aim of the work was to study the delayed effect of lipopolysaccharide (LPS) administration on endothelial function of the aorta of rats with genetic hypertension. Further, the possibility to ameliorate LPS-induced changes by n-3 polyunsaturated fatty acids (n-3 PUFA) was tested. Rats received a bolus of 1 mg/kg LPS i.p.; n-3 PUFA were administered in the dose of 30 mg/kg daily for 10 days p.o.. Ten days after receiving of LPS, the body weight gain of rats was statistically lower compared to control rats (p < 0...
July 2017: General Physiology and Biophysics
https://www.readbyqxmd.com/read/28635361/role-of-licochalcone-a-in-vegf-induced-proliferation-of-human-airway-smooth-muscle-cells-implications-for-asthma
#2
Sung-Ho Kim, Qing-Mei Pei, Ping Jiang, Min Yang, Xue-Jiao Qian, Jiang-Bo Liu
Asthma is a chronic respiratory disease characterized by reversible airway obstruction with persistent airway inflammation and airway remodeling, which is associated with increased airway smooth muscle (ASM) mass. Licochalcone A is the predominant characteristic chalcone in licorice root. We found that licochalcone A inhibited vascular endothelial growth factor (VEGF)-induced ASM cell proliferation and induced cell cycle arrest. Additionally, VEGF-induced ASM cell proliferation was suppressed via inhibition of extracellular signal-regulated kinase 1/2 (ERK1/2) activity, but not that of Akt...
February 2017: Growth Factors
https://www.readbyqxmd.com/read/28635324/gliptins-suppress-inflammatory-macrophage-activation-to-mitigate-inflammation-fibrosis-oxidative-stress-and-vascular-dysfunction-in-models-of-non-alcoholic-steatohepatitis-and-liver-fibrosis
#3
Xiaoyu Wang, Michael Hausding, Shih-Yen Weng, Yong Ook Kim, Sebastian Steven, Thomas Klein, Andreas Daiber, Detlef Schuppan
AIMS: Non-alcoholic steatohepatitis (NASH) is characterized by steatosis, panlobular inflammation, liver fibrosis and increased cardiovascular mortality. Dipeptidyl peptidase-4 (DPP-4) inhibitors (gliptins) are indirect glucagon like peptide 1 (GLP-1) agonists with antidiabetic and anti-inflammatory activity, used for the treatment of type 2 diabetes. Their potential and underlying mechanisms to treat metabolic liver inflammation and fibrosis as well as the associated vascular dysfunction remain to be explored...
June 21, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28634464/anti-inflammatory-and-neuroprotective-effects-of-co-ultrapealut-in-a-mouse-model-of-vascular-dementia
#4
Rosalba Siracusa, Daniela Impellizzeri, Marika Cordaro, Rosalia Crupi, Emanuela Esposito, Stefania Petrosino, Salvatore Cuzzocrea
Vascular dementia (VaD), the second most common cause of cognitive impairment in the population, is a disease that results from reduction in regional cerebral blood flow and involves oxidative stress and inflammation. Co-ultramicronized PEALut (co-ultra PEALut) is a new compound with beneficial effects, which include anti-inflammatory and antioxidant properties. Recently, co-ultraPEALut has been shown to exhibit neuroprotective effects in models of Parkinson's disease, cerebral ischemia and Alzheimer's disease...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28634421/the-role-of-von-willebrand-factor-in-vascular-inflammation-from-pathogenesis-to-targeted-therapy
#5
REVIEW
Felice Gragnano, Simona Sperlongano, Enrica Golia, Francesco Natale, Renatomaria Bianchi, Mario Crisci, Fabio Fimiani, Ivana Pariggiano, Vincenzo Diana, Andreina Carbone, Arturo Cesaro, Claudia Concilio, Giuseppe Limongelli, Mariagiovanna Russo, Paolo Calabrò
Beyond its role in hemostasis, von Willebrand factor (VWF) is an emerging mediator of vascular inflammation. Recent studies highlight the involvement of VWF and its regulator, ADAMTS13, in mechanisms that underlie vascular inflammation and immunothrombosis, like leukocyte rolling, adhesion, and extravasation; vascular permeability; ischemia/reperfusion injury; complements activation; and NETosis. The VWF/ADAMTS13 axis is implicated in the pathogenesis of atherosclerosis, promoting plaque formation and inflammation through macrophage and neutrophil recruitment in inflamed lesions...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28634267/30-years-of-the-mineralocorticoid-receptor-the-role-of-the-mineralocorticoid-receptor-in-the-vasculature
#6
REVIEW
Jennifer J DuPont, Iris Z Jaffe
Since the mineralocorticoid receptor (MR) was cloned 30 years ago, it has become clear that MR is expressed in extra-renal tissues, including the cardiovascular system, where it is expressed in all cells of the vasculature. Understanding the role of MR in the vasculature has been of particular interest as clinical trials show that MR antagonism improves cardiovascular outcomes out of proportion to changes in blood pressure. The last 30 years of research have demonstrated that MR is a functional hormone-activated transcription factor in vascular smooth muscle cells and endothelial cells...
July 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28632747/selective-cyclooxygenase-inhibition-by-sc-560-improves-hepatopulmonary-syndrome-in-cirrhotic-rats
#7
Ching-Chih Chang, Wen-Shin Lee, Hsian-Guey Hsieh, Chiao-Lin Chuang, Hui-Chun Huang, Fa-Yauh Lee, Shou-Dong Lee
OBJECTIVE: Hepatopulmonary syndrome (HPS) is characterized by hypoxia in patients with chronic liver disease. The mechanism of HPS includes pulmonary vasodilatation, inflammation, and angiogenesis. Prostaglandins synthesized by cyclooxygenases (COX) participate in vascular responsiveness, inflammation and angiogenesis, which can be modulated by COX inhibitors. We therefore evaluated the impact of COX inhibition in rats with common bile duct ligation (CBDL)-induced liver cirrhosis and HPS...
2017: PloS One
https://www.readbyqxmd.com/read/28632169/the-novel-mechanisms-concerning-the-inhibitions-of-palmitate-induced-proinflammatory-factor-releases-and-endogenous-cellular-stress-with-astaxanthin-on-min6-%C3%AE-cells
#8
Atsuko Kitahara, Kazuto Takahashi, Naru Morita, Toshitaka Murashima, Hirohisa Onuma, Yoshikazu Sumitani, Toshiaki Tanaka, Takuma Kondo, Toshio Hosaka, Hitoshi Ishida
Astaxanthin, an antioxidant agent, can protect pancreatic β-cells of db/db mice from glucotoxicity and resolve chronic inflammation in adipose tissue. Nonetheless, the effects of astaxanthin on free-fatty-acid-induced inflammation and cellular stress in β-cells remain to be demonstrated. Meanwhile, palmitate enhances the secretion of pro-inflammatory adipokines monocyte chemoattractant protein-1 (MCP-1) and VEGF120 (vascular endothelial growth factor). We therefore investigated the influence of astaxanthin on palmitate-stimulated MCP-1 and VEGF120 secretion in mouse insulinoma (MIN6) pancreatic β-cells...
June 20, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28631505/methylglyoxal-derived-hydroimidazolone-1-evokes-inflammatory-reactions-in-endothelial-cells-via-an-interaction-with-receptor-for-advanced-glycation-end-products
#9
Yuji Ishibashi, Takanori Matsui, Nobutaka Nakamura, Ami Sotokawauchi, Yuichiro Higashimoto, Sho-Ichi Yamagishi
OBJECTIVE: Glyceraldehyde-derived advanced glycation end products contribute to vascular inflammation in diabetes. However, what advanced glycation end product structure could evoke inflammatory reactions remains unknown. We examined whether and how methylglyoxal-derived hydroimidazolone 1, one of the advanced glycation end products formed from glyceraldehyde, elicits inflammatory reactions in human umbilical vein endothelial cells. MATERIALS AND METHODS: Glyceraldehyde-advanced glycation end products-aptamer was prepared using a systemic evolution of ligands by exponential enrichment...
June 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28631302/l-hcy-induced-cathepsin-v-mediates-the-vascular-endothelial-inflammation-in-hyperhomocysteinemia
#10
Yi-Ping Leng, Ye-Shuo Ma, Xiao-Gang Li, Rui-Fang Chen, Ping-Yu Zeng, Xiao-Hui Li, Cheng-Feng Qiu, Ya-Pei Li, Zhen Zhang, Alex F Chen
BACKGROUND AND PURPOSE: Vascular inflammation, including the expression of inflammatory cytokines in endothelial cells, plays a critical role in hyperhomocysteinemia-associated vascular diseases. Cathepsin V, specifically expressed in humans, is involved in vascular diseases through its elastolytic and collagenolytic activities. The aim of this study was to determine the effects of cathepsin V on the L-homocysteine (L-Hcy)-induced vascular inflammation. EXPERIMENTAL APPROACH: A high methionine diet-induced hyperhomocysteinemic mice model was used to assess the cathepsin V expression and vascular inflammation...
June 20, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28631245/hypoxia-and-inflammation-in-the-release-of-vegf-and-interleukins-from-human-retinal-pigment-epithelial-cells
#11
Olli Arjamaa, Vesa Aaltonen, Niina Piippo, Tamás Csont, Goran Petrovski, Kai Kaarniranta, Anu Kauppinen
PURPOSE: Retinal diseases are closely associated with both decreased oxygenation and increased inflammation. It is not known if hypoxia-induced vascular endothelial growth factor (VEGF) expression in the retina itself evokes inflammation, or whether inflammation is a prerequisite for the development of neovascularization. METHODS: Human ARPE-19 cell line and primary human retinal pigment epithelium (RPE) cells were used. ARPE-19 cells were kept either under normoxic (24 h or 48 h) or hypoxic conditions (1% O2, 24 h)...
June 19, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28630926/vasculogenic-hydrogel-enhances-islet-survival-engraftment-and-function-in-leading-extrahepatic-sites
#12
Jessica D Weaver, Devon M Headen, Jahizreal Aquart, Christopher T Johnson, Lonnie D Shea, Haval Shirwan, Andrés J García
Islet transplantation is a promising alternative therapy for insulin-dependent patients, with the potential to eliminate life-threatening hypoglycemic episodes and secondary complications of long-term diabetes. However, widespread application of this therapy has been limited by inadequate graft function and longevity, in part due to the loss of up to 60% of the graft in the hostile intrahepatic transplant site. We report a proteolytically degradable synthetic hydrogel, functionalized with vasculogenic factors for localized delivery, engineered to deliver islet grafts to extrahepatic transplant sites via in situ gelation under physiological conditions...
June 2017: Science Advances
https://www.readbyqxmd.com/read/28630603/elevated-il-37-levels-in-the-plasma-of-patients-with-severe-coronary-artery-calcification
#13
Meng Chai, Hai-Tao Zhang, Yu-Jie Zhou, Qing-Wei Ji, Qing Yang, Yu-Yang Liu, Ying-Xin Zhao, Dong-Mei Shi, Wei Liu, Li-Xia Yang, Lin-Lin Zhang, Jing Liang
BACKGROUND: Coronary artery calcification (CAC) is a predictor of cardiovascular events and plaque burden and is closely associated with chronic inflammation. Interleukin (IL)-37 is a newly discovered member of the IL-1 family and is considered an anti-inflammatory cytokine. Our recent study on mice indicated that IL-37 could attenuate atherosclerosis and vascular calcification, which suggests that IL-37 could be associated with the development of atherosclerosis and related diseases...
May 2017: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/28630485/acute-administration-of-catalase-targeted-to-icam-1-attenuates-neuropathology-in-experimental-traumatic-brain-injury
#14
Evan M Lutton, Roshanak Razmpour, Allison M Andrews, Lee Anne Cannella, Young-Jin Son, Vladimir V Shuvaev, Vladimir R Muzykantov, Servio H Ramirez
Traumatic brain injury (TBI) contributes to one third of injury related deaths in the US. Treatment strategies for TBI are supportive, and the pathophysiology is not fully understood. Secondary mechanisms of injury in TBI, such as oxidative stress and inflammation, are points at which intervention may reduce neuropathology. Evidence suggests that reactive oxygen species (ROS) propagate blood-brain barrier (BBB) hyperpermeability and inflammation following TBI. We hypothesized that targeted detoxification of ROS may improve the pathological outcomes of TBI...
June 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28629772/impact-of-the-cardiovascular-system-associated-adipose-tissue-on-atherosclerotic-pathology
#15
REVIEW
Dimitry A Chistiakov, Andrey V Grechko, Veronika A Myasoedova, Alexandra A Melnichenko, Alexander N Orekhov
Cardiac obesity makes an important contribution to the pathogenesis of cardiovascular disease. One of the important pathways of this contribution is the inflammatory process that takes place in the adipose tissue. In this review, we consider the role of the cardiovascular system-associated fat in atherosclerotic cardiovascular pathology and a non-atherosclerotic cause of coronary artery disease, such as atrial fibrillation. Cardiovascular system-associated fat not only serves as the energy store, but also releases adipokines that control local and systemic metabolism, heart/vascular function and vessel tone, and a number of vasodilating and anti-inflammatory substances...
June 8, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28629689/advanced-power-doppler-technique-increases-synovial-vascularity-detection-in-patients-with-rheumatoid-arthritis
#16
Davide Orlandi, Salvatore Gitto, Silvia Perugin Bernardi, Angelo Corazza, Luca De Flaviis, Enzo Silvestri, Marco Amedeo Cimmino, Luca Maria Sconfienza
We compared the diagnostic performance of an advanced power Doppler technique (superb microvascular imaging [SMI]) with that of power Doppler Imaging (PDI) and B-mode ultrasound (US) in patients with early rheumatoid arthritis (RA) and RA under treatment with rituximab. Thirty patients (21 women aged 45 ± 11 y) affected by RA with remission to moderate disease activity were examined. Both hand joints were evaluated using US, PDI and SMI. Two radiologists reviewed all video clips and evaluated synovial vascularity intensity using a semi-quantitative scoring system...
June 16, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28629640/is-physical-activity-a-modifier-of-the-association-between-air-pollution-and-arterial-stiffness-in-older-adults-the-sapaldia-cohort-study
#17
Simon Endes, Emmanuel Schaffner, Seraina Caviezel, Julia Dratva, Daiana Stolz, Christian Schindler, Nino Künzli, Arno Schmidt-Trucksäss, Nicole Probst-Hensch
INTRODUCTION AND OBJECTIVES: Air pollution and insufficient physical activity have been associated with inflammation and oxidative stress, molecular mechanisms linked to arterial stiffness and cardiovascular disease. There are no studies on how physical activity modifies the association between air pollution and arterial stiffness. We examined whether the adverse cardiovascular effects of air pollution were modified by individual physical activity levels in 2823 adults aged 50-81 years from the well-characterized Swiss Cohort Study on Air Pollution and Lung and Heart Diseases (SAPALDIA)...
June 13, 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/28628153/-13-cases-of-littoral-cell-angioma-in-spleens
#18
(no author information available yet)
OBJECTIVE: To investigate the clinicopathological features, morphological characteristics, immunophenotypes of littoral cell angioma (LCA) in spleen, and to provide new evidence for making diagnosis and avoiding misdiagnosis. METHODS: Clinicopathological data, histological characteristics of 13 cases of LCA were retrospectively studied and immunohistochemical staining was imposed on the paraffi-nembedded specimens, and 5 cases of cavernous hemangioma, 4 cases of normal littoral cells of spleens were used as control groups, simultaneously...
June 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28627664/sodium-tanshinone-iia-sulfonate-suppresses-heat-stress-induced-endothelial-cell-apoptosis-by-promoting-no-production-through-upregulating-the-pi3k-akt-enos-pathway
#19
Qing Cheng, Yan Zhao, Jianguo Li
Heat shock is a life-threatening disease involving systematic inflammation that is closely related to endothelial injury and can lead to multiple organ dysfunction syndrome. Sodium tanshinone IIA sulfonate (STS) has various functions in the vascular endothelium. In the present study, STS is presented to suppress heat stress‑induced apoptosis of human umbilical vein endothelial cells (HUVECs) and high ambient temperature‑induced systematic inflammation in Sprague Dawley rats. In addition, the STS apoptosis‑suppression mechanism was explored...
June 13, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28627342/-baicalein-attenuates-acute-lung-injury-induced-by-intestinal-ischemia-reperfusion-via-inhibition-of-nuclear-factor-%C3%AE%C2%BAb-pathway-in-mice
#20
Lei Chu, Fenyong Zhu, Wenjun Zhou, Zhongxiang Du, Jie Li, Xiaohong Wang, Lihui Wang, Anding Liu
OBJECTIVE: To investigate the effects of baicalein (Bai) on acute lung injury (ALI) induced by intestinal ischemia/reperfusion (I/R) and its mechanism in mice. METHODS: Twenty-four male C57BL/6J mice were divided into three groups by random number table: namely sham group, I/R group and Bai+I/R group, with 8 mice in each group. Intestinal I/R induced lung injury model was reproduced by clamping superior mesenteric artery for 90 minutes, followed by reperfusion. Bai (100 mg/kg) was intraperitoneally injected 1 hour before ischemic challenge in the Bai+I/R group...
March 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
keyword
keyword
57612
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"