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Cefepime sulbactam

Mona M Abdelkader, Khaled M Aboshanab, Marwa A El-Ashry, Mohammad M Aboulwafa
The aim of this study was identifying bacterial pathogens involved in meningitis, studying their antibiotic resistance profiles, investigating the antibiotic resistance genes as well as evaluating the use of various antibiotic combinations. Antibiotic susceptibility tests were evaluated according to CLSI guidelines. Antibiotic combinations were evaluated by calculating the Fractional Inhibitory Concentration (FIC) index. A total of 71 bacterial isolates were recovered from 68 culture positive CSF specimens...
2017: PloS One
Fatih Şaban Beriş, Emine Esra Budak, Duygu Gülek, Aytül Uzun, Zeynep Çizmeci, Fırat Zafer Mengeloğlu, Şahin Direkel, Yeliz Çetinkol, Yasemin Ay Altıntop, Meryem Iraz, Tuba Dal, Safiye Umut Say Coşkun, Pervin Özlem Balcı, Tuba Kayman, Ahmet Çalışkan, Yelda Yazıcı, İsmail Tosun, Ayşe Ertürk, Ayşegül Çopur Çiçek
The diversity and distribution of TEM, SHV and CTX-M type of extended-spectrum beta-lactamases (ESBLs) are important for the treatment and control of infections. Determination of ESBL genes in clinical isolates by polymerase chain reaction (PCR) and DNA sequencing can obtain useful data for their molecular epidemiology and risk. The aim of this study was to investigate the frequency of beta-lactamase genes in Acinetobacter baumannii strains isolated from different regions of Turkey. A total of 519 A.baumannii strains collected from hospitals located at 12 different provinces of Turkey (Bolu (n= 67), Tokat (n= 47), Trabzon (n= 25), Ordu (n= 27), Diyarbakır (n= 47), Niğde (n=31), Kayseri (n= 36), Ankara (n= 41), Kirikkale (n= 26), Kahramanmaraş (n= 25), Mersin (n= 40), Istanbul (n= 107)] between 2011-2012 period were included in the study...
October 2016: Mikrobiyoloji Bülteni
Chih-Chien Chiu, Tzu-Chao Lin, Rui-Xin Wu, Ya-Sung Yang, Po-Jen Hsiao, Yi Lee, Jung-Chung Lin, Feng-Yee Chang
BACKGROUND: Community-onset urinary tract infections (CoUTIs) are the most common bacterial infections, and a decline in antibiotic susceptibility causes many clinical challenges. Adequate empiric antibiotic treatment can decrease unnecessary hospital stays and complications, while reducing the antimicrobial resistance progression. METHODS: From October 2014 to April 2015, we retrospectively enrolled patients who were at least 18 years old and required hospitalization for CoUTIs...
December 18, 2016: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
Wonhee So, Liz Kim, Abrar K Thabit, David P Nicolau, Joseph L Kuti
PURPOSE: The physical compatibility of isavuconazonium sulfate with 95 i.v. drugs during simulated Y-site administration was studied. METHODS: Isavuconazonium sulfate for injection and all other drugs were reconstituted according to the manufacturer's recommendation and further diluted with 0.9% sodium chloride injection or 5% dextrose injection to a final concentration (1.5 mg/mL for isavuconazonium sulfate and standard concentrations used clinically for other drugs)...
January 1, 2017: American Journal of Health-system Pharmacy: AJHP
Annelien Everaert, Tom Coenye
BACKGROUND: Bacteria belonging to the Burkholderia cepacia complex (Bcc) are an important cause of chronic respiratory tract infections in cystic fibrosis patients. Intrinsic resistance to a wide range of antimicrobial agents, including a variety of β-lactam antibiotics, is frequently observed in Bcc strains. Resistance to β-lactams is most commonly mediated by efflux pumps, alterations in penicillin-binding proteins or the expression of β-lactamases. β-lactamase inhibitors are able to restore the in vitro activity of β-lactam molecules against a variety of Gram-negative species, but the effect of these inhibitors on the activity of β-lactam treatment against Bcc species is still poorly investigated...
2016: Antimicrobial Resistance and Infection Control
Shailesh C Trivedi, Sanjeev R Phatak, Renu S Trivedi
INTRODUCTION: Acute Pyelonephritis (APN) is a common infection in community. Diabetes Mellitus (DM) may have different effect on clinical characteristics and outcomes of APN compared to non-diabetic individuals. AIM: To compare clinical characteristics and assess outcomes of APN patients with and without DM. MATERIALS AND METHODS: A retrospective analysis of 122 patients with DM (n=61) and without DM (n=61) was conducted at a single, private, urban set-up from Gujarat, India...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
Sofia Maraki, Elpis Mantadakis, Viktoria Eirini Mavromanolaki, Diamantis P Kofteridis, George Samonis
BACKGROUND: Acinetobacter baumannii has emerged as a major cause of nosocomial outbreaks. It is particularly associated with nosocomial pneumonia and bloodstream infections in immunocompromised and debilitated patients with serious underlying pathologies. Over the last two decades, a remarkable rise in the rates of multidrug resistance to most antimicrobial agents that are active against A. baumannii has been noted worldwide. We evaluated the rates of antimicrobial resistance and changes in resistance over a 5-year period (2010-2014) in A...
September 2016: Infection & Chemotherapy
Y L Gong, Z C Yang, S P Yin, M X Liu, C Zhang, X Q Luo, Y Z Peng
Objective: To analyze the distribution and drug resistance of pathogen isolated from severely burned patients with bloodstream infection, so as to provide reference for the clinical treatment of these patients. Methods: Blood samples of 162 severely burned patients (including 120 patients with extremely severe burn) with bloodstream infection admitted into our burn ICU from January 2011 to December 2014 were collected. Pathogens were cultured by fully automatic blood culture system, and API bacteria identification panels were used to identify pathogen...
September 20, 2016: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
Saori Fukuda, Masaru Komatsu, Tatuya Nakamura, Takumi Jikimoto, Hisaaki Nishio, Katsutoshi Yamasaki, Kaori Satoh, Hirofumi Toda, Tamaki Orita, Noriyuki Sueyoshi, Machiko Kita, Isao Nishi, Masahiro Akagi, Takeshi Higuchi, Tomomi Kofuku, Isako Nakai, Tamotsu Ono, Kaneyuki Kida, Masanobu Ohama, Hideo Watari, Satoshi Shimura, Makoto Niki, Tomokazu Kuchibiro, Yasunao Wada
A study was conducted of the 1,225 Pseudomonas aeruginosa strains that were isolated at 20 medical institutions in the Kinki district between 2011 and 2013 to determine their antimicrobial susceptibility and to characterize the strains of multidrug-resistant Pseudomonas aeruginosa (MDRP) and the metallo-β-lactamase (MBL) -producing strains. The MIC50/MIC90 values (μg/mL) of the various antimicrobial agents were as follows: imipenem, 2/>8; meropenem, 1/>8; doripenem, 0.5/8; biapenem, 1/>8; tazobactam/piperacillin, 8/>64; piperacillin, 8/>64; sulbactam/cefoperazone, 8/64; cefepime, 4/16; cefozopran, 2/>16; aztreonam, 8/>16; amikacin, 4/16; levofloxacin, 1/>4; and ciprofloxacin, 0...
April 2016: Japanese Journal of Antibiotics
Capan Konca, Mehmet Tekin, Fatih Uckardes, Sadik Akgun, Habip Almis, Ibrahim Hakan Bucak, Yeliz Genc, Mehmet Turgut
BACKGROUND: Urinary tract infections (UTIs) are common infections affecting children. In this study, in order to determine a guide for the empirical antibiotic treatment of community-acquired UTIs, we aimed to investigate the etiology and antimicrobial resistance patterns of uropathogens and to evaluate epidemiological and clinical characteristics of patients. METHODS: A total of 158 children with a positive urine culture were included in the study. Antibiotic susceptibility testing was performed by Vitek 2 Compact for twenty eight commonly used antimicrobials...
August 20, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
C Del Rio-Avila, C Rosario, S Arroyo-Escalante, E M Carrillo-Casas, E Díaz-Aparicio, F Suarez-Güemes, J Silva-Sanchez, J Xicohtencatl-Cortes, P Maravilla, R Hernández-Castro
Forty-two enrofloxacin-resistant Escherichia coli strains isolated from eggs and first-week mortality associated with yolk sac infection of two vertically integrated poultry companies of Central Mexico in 1997 and 2005 were characterised. E. coli resistance to 19 antibiotics was determined, as well as the minimum inhibitory concentrations (broth dilution) for ciprofloxacin. The presence of gyrA,B, parC,E chromosomal point mutations, qnrA,B,S plasmid genes and the aminoglycoside acetyltransferase aac(6')-Ib-cr were determined by PCR and sequencing...
August 2016: British Poultry Science
Geehan Suleyman, Mary Perri, Dora Vager, Linoj Samuel, Marcos J Zervos, George Alangaden, Robert J Tibbetts
Over an approximately 50-day period in 2015, an outbreak of CTX-M-15 extended spectrum β-lactamase-(ESBL)-possessing Salmonella Isangi occurred among 19 adult surgical patients and one healthcare worker (HCW) at a large urban tertiary care hospital in the United States. A total of 45 S. Isangi isolates were isolated from stool (35), blood (4), urine (3), respiratory (2), and wound (1) cultures. Phenotypically, all but three isolates demonstrated resistance to ampicillin, ampicillin/sulbactam, ceftriaxone, and cefepime, and one isolate was resistant to ertapenem...
July 2016: Diagnostic Microbiology and Infectious Disease
Ya-Sung Yang, Yi Lee, Kuo-Chuan Tseng, Wei-Cheng Huang, Ming-Fen Chuang, Shu-Chen Kuo, Tsai-Ling Yang Lauderdale, Te-Li Chen
Minocycline-based combination therapy has been suggested to be a possible choice for the treatment of infections caused by minocycline-susceptible Acinetobacter baumannii, but its use for the treatment of infections caused by minocycline-resistant A. baumannii is not well established. In this study, we compared the efficacy of minocycline-based combination therapy (with colistin, cefoperazone-sulbactam, or meropenem) to that of colistin in combination with meropenem for the treatment of minocycline-resistant A...
July 2016: Antimicrobial Agents and Chemotherapy
Josef Yayan, Beniam Ghebremedhin, Kurt Rasche
BACKGROUND: Many antibiotics have no effect on Gram-positive and Gram-negative microbes, which necessitates the prescription of broad-spectrum antimicrobial agents that can lead to increased risk of antibiotic resistance. These pathogens constitute a further threat because they are also resistant to numerous beta-lactam antibiotics, as well as other antibiotic groups. This study retrospectively investigates antimicrobial resistance in hospitalized patients suffering from pneumonia triggered by Gram-negative Serratia marcescens or Proteus mirabilis...
March 23, 2016: BMC Pharmacology & Toxicology
Summaiya Mulla, Jaykaran Charan, Sangita Rajdev
BACKGROUND: Some studies published in recent time revealed that many bacteria from Enterobacteriaceae group are multi-antibiotic-resistant because of the production enzymes carbapenemase particularly New Delhi metallo-beta-lactamase encoded by gene called blaNDM-1. Looking at public health importance of this issue there is a need for studies at other centers to confirm or refute published findings. OBJECTIVES: This study was designed with the aim of exploring antibiotic resistance in Enterobacteriaceae group of bacteria and also to explore gene and enzyme responsible for it...
January 2016: International Journal of Applied and Basic Medical Research
A Batarseh, A Al-Sarhan, M Maayteh, S Al-Khatirei, M Alarmouti
This study was conducted to determine the prevalence and the local antibiogram of multidrug-resistant Acinetobacter baumannii isolates in Al-Hussein Hospital at King Hussein Medical Centre in Amman, Jordan. In a retrospective study from January to December 2013, data on 116 non-repetitive positive clinical samples were retrieved from patients' laboratory records. The resistance rates of A. baumannii isolates were high for ceftriaxone, cefotaxime and ticarcillin (100%), ceftazidime, cefepime and piperacillin (98...
February 1, 2016: Eastern Mediterranean Health Journal, la Revue de Santé de la Méditerranée Orientale
Adel A Hagag, Samir M Hassan, Mohamed A Elgamasy, Ibtesam K Afifi
BACKGROUND: Infection 'is a common complication in children with hematological malignancies' during febrile neutropenia. ' OBJECTIVE: The aim of this study was to' evaluate common bacterial and fungal pathogens in children with hematological malignancies during febrile neutropenia in single center Egyptian study. ' PATIENTS AND METHODS: This study was carried out on 90' children with hematological malignancies during febrile neutropenia including 54 with ALL, 27 with AML and 9 with NHL with their ages ranging from 2...
2016: Infectious Disorders Drug Targets
Qi Wang, Hui Wang, Yunsong Yu, Xiuli Xu, Ziyong Sun, Juan Lu, Bin Yang, Liyan Zhang, Zhidong Hu, Xianju Feng, Yingchun Xu, Yuxing Ni, Yaning Mei, Kang Liao, Ping Ji, Yunzhuo Chu
OBJECTIVE: To investigate the current situation of antimicrobial resistance of nosocomial gram-negative bacilli in 2014 in China. METHODS: About 1 430 consecutive and non-repetitive strains of gram-negative bacilli were isolated from 15 teaching hospitals from March to August in 2014. All of these isolates were sent to the central laboratory for reidentification and susceptibility testing. The minimal inhibitory concentration (MIC) of meropenem and other antibacterial agents were determined by agar dilution method...
October 2015: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
Ruike Zhao, Jinfang Shi, Yimin Shen, Yanmeng Li, Qingzhen Han, Xianfeng Zhang, Guohao Gu, Jie Xu
OBJECTIVES: The present study was aimed to investigate the antibiotic resistance, virulence potential and phylogenetic grouping of ESBL-producing uropathogenic Escherichia coli (EP-UPEC) isolated from long-term hospitalized patients. MATERIALS AND METHODS: EP-UPEC isolates from September 2013 to June 2014 at a tertiary care hospital of China were screened for ESBL-production by the double disk diffusion test. Isolates with ESBL-phenotype were further characterized by antibiotic resistance testing, PCR of different ESBL and virulence genes, and phylogenetic grouping...
July 2015: Journal of Clinical and Diagnostic Research: JCDR
Meryem Iraz, Azer Özad Düzgün, Cemal Sandallı, Mehmet Ziya Doymaz, Yasemin Akkoyunlu, Ayşegül Saral, Anton Y Peleg, Osman Birol Özgümüş, Fatih Şaban Beriş, Hakan Karaoğlu, Ayşegül Çopur Çiçek
BACKGROUND: The emergence of carbapenem-resistant Klebsiella pneumoniae poses a serious problem to antibiotic management. We investigated the β-lactamases in a group of carbapenem-resistant K. pneumoniae clinical isolates from Turkey. METHODS: Thirty-seven strains of K. pneumoniae isolated from various clinical specimens were analyzed by antimicrobial susceptibility testing, PCR for the detection of β-lactamase genes, DNA sequencing, and repetitive extragenic palindronic (REP)-PCR analysis...
November 2015: Annals of Laboratory Medicine
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