Hillary Nepon, Raphaela Allgayer, Cedric Julien, Sarah Petrecca, Nikita Kalashnikov, Tyler Safran, Amanda Murphy, Tassos Dionisopolous, Peter Davison, Marta Cerruti, Joshua Vorstenbosch
Soft implantable devices are crucial to optimizing form and function for many patients. However, periprosthetic capsule fibrosis is one of the major challenges limiting the use of implants. Currently, little is understood about how spatial and temporal factors influence capsule physiology and how the local capsule environment affects the implant structure. In this work, we analyzed breast implant capsule specimens with staining, immunohistochemistry, and real-time polymerase chain reaction to investigate spatiotemporal differences in inflammation and fibrosis...
April 19, 2024: ACS Biomaterials Science & Engineering