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https://www.readbyqxmd.com/read/28916031/dermatosis-papulosa-nigra-a-clinically-and-histopathologically-distinct-entity
#1
Simon Arda Metin, Brian W Lee, William Clark Lambert, Lawrence Charles Parish
Dermatosis papulosa nigra was first described by Aldo Castellani (1874-1971) more than 90 years ago, and it has since been presumed to be a variant of seborrheic keratosis. Despite their morphologic similarities both macroscopically and microscopically, key differences have yet to be explained. These lesions also exhibit different demographics, with dermatosis papulosa nigra having a predilection for dark-skinned individuals and a female predominance. No studies to date have investigated this, but studies assessing the mechanisms of similar dermatologic conditions may yield significant clues...
September 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/28894850/cost-effectiveness-of-breast-cancer-screening-in-turkey-a-developing-country-results-from-bah%C3%A3-e%C3%A5-ehir-mammography-screening-project
#2
Vahit Özmen, Sibel Ö Gürdal, Neslihan Cabioğlu, Beyza Özcinar, A Nilüfer Özaydın, Arda Kayhan, Erkin Arıbal, Cennet Sahin, Pınar Saip, Oğuzhan Alagöz
OBJECTIVE: We used the results from the first three screening rounds of Bahcesehir Mammography Screening Project (BMSP), a 10-year (2009-2019) and the first organized population-based screening program implemented in a county of Istanbul, Turkey, to assess the potential cost-effectiveness of a population-based mammography screening program in Turkey. MATERIALS AND METHODS: Two screening strategies were compared: BMSP (includes three biennial screens for women between 40-69) and Turkish National Breast Cancer Registry Program (TNBCRP) which includes no organized population-based screening...
July 2017: Eur J Breast Health
https://www.readbyqxmd.com/read/28893946/a-radial-axis-defined-by-semaphorin-to-neuropilin-signaling-controls-pancreatic-islet-morphogenesis
#3
Philip T Pauerstein, Krissie Tellez, Kirk B Willmarth, Keon Min Park, Brian Hsueh, H Efsun Arda, Xueying Gu, Haig Aghajanian, Karl Deisseroth, Jonathan A Epstein, Seung K Kim
The islets of Langerhans are endocrine organs characteristically dispersed throughout the pancreas. During development, endocrine progenitors delaminate, migrate radially, and cluster to form islets. Despite the distinctive distribution of islets, spatially localized signals that control islet morphogenesis have not been discovered. Here we identify a radial signaling axis that instructs developing islet cells to disperse throughout the pancreas. A screen of pancreatic extracellular signals identified factors that stimulated islet cell development...
September 11, 2017: Development
https://www.readbyqxmd.com/read/28890466/changes-in-aortic-pulse-wave-velocity-and-the-predictors-of-improvement-in-arterial-stiffness-following-aortic-valve-replacement
#4
Emir Cantürk, Beytullah Çakal, Oğuz Karaca, Onur Omaygenç, Salih Salihi, Arda Özyüksel, Atıf Akçevin
BACKGROUND: The interaction between valvular aortic stenosis (AS) and arterial stiffness, as well as the impact of aortic valve replacement (AVR) on arterial stiffness, remains unclear. In this study, we aimed to evaluate the degree of AS severity on non-invasive pulse wave velocity (PWV) measurements. We also searched whether the AVR procedure favorably affects PWV. METHODS: In all, 38 patients undergoing AVR for chronic AS were included. The degree of aortic stiffness was measured with PWV at both baseline and 6 months after AVR...
September 8, 2017: Annals of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28880313/3d-printed-poly-%C3%AE%C2%B5-caprolactone-scaffolds-modified-with-hydroxyapatite-and-poly-propylene-fumarate-and-their-effects-on-the-healing-of-rabbit-femur-defects
#5
Senem Buyuksungur, Tugba Endogan Tanir, Arda Buyuksungur, Ezgi Irem Bektas, Gamze Torun Kose, Deniz Yucel, Tahsin Beyzadeoglu, Engin Cetinkaya, Cagri Yenigun, Ergin Tönük, Vasif Hasirci, Nesrin Hasirci
A large variety of approaches have been used to treat large and irregular shaped bone defects with less than optimal success due to material or design issues. In recent years patient specific constructs prepared by additive manufacturing provided a solution to the need for shaping implants to fit irregular defects in the surgery theater. In this study, cylindrical disks of poly(ε-caprolactone) (PCL) were printed by fused deposition modeling and modified with nanohydroxyapatite (HAp) and poly(propylene fumarate) (PPF) to create a mechanically strong implant with well-defined pore size and porosity, controllable surface hydrophilicity (with PPF) and osteoconductivity (with HAp)...
September 7, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28875572/hybrid-3d-printing-of-soft-electronics
#6
Alexander D Valentine, Travis A Busbee, John William Boley, Jordan R Raney, Alex Chortos, Arda Kotikian, John Daniel Berrigan, Michael F Durstock, Jennifer A Lewis
Hybrid 3D printing is a new method for producing soft electronics that combines direct ink writing of conductive and dielectric elastomeric materials with automated pick-and-place of surface mount electronic components within an integrated additive manufacturing platform. Using this approach, insulating matrix and conductive electrode inks are directly printed in specific layouts. Passive and active electrical components are then integrated to produce the desired electronic circuitry by using an empty nozzle (in vacuum-on mode) to pick up individual components, place them onto the substrate, and then deposit them (in vacuum-off mode) in the desired location...
September 6, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28859731/acne-keloidalis-nuchae-is-the-barber-really-to-blame
#7
EDITORIAL
Simon Arda Metin, Lawrence Charles Parish
No abstract text is available yet for this article.
2017: Skinmed
https://www.readbyqxmd.com/read/28845679/micro-ct-and-nano-ct-analysis-of-filling-quality-of-three-different-endodontic-sealers
#8
Yan Huang, Berkan Celikten, Karla de Faria Vasconcelos, Laura Ferreira Pinheiro Nicolielo, Nicholas Lippiatt, Arda Buyuksungur, Reinhilde Jacobs, Kaan Orhan
OBJECTIVES: To investigate voids in different root canal sealers using micro-CT and nano-CT, and to explore the feasibility of using nano-CT for quantitative analysis of sealer filling quality. METHODS: Thirty extracted mandibular central incisors were randomly assigned into three groups according to the applied root canal sealers (Total BC Sealer, Sure Seal Root, AH Plus) by the single cone technique. Subsequently, micro-CT and nano-CT were performed to analyze the incidence rate of voids, void fraction, void volume and their distribution in each sample...
August 27, 2017: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/28769833/possession-zone-as-a-performance-indicator-in-football-the-game-of-the-best-teams
#9
Claudio A Casal, Rubén Maneiro, Toni Ardá, Francisco J Marí, José L Losada
Possession time in football has been widely discussed in research but few studies have analyzed the importance of the field area in which possession occurs. The objective of this study was to identify the existence of significant differences in the field zone of ball possession between successful and unsuccessful teams and to acknowledge if the match status modulates the possession model. To this end, 2,284 attacks were analyzed corresponding to the matches in the final phase of the UEFA Euro 2016 France, recording possession time and field zone in which possession occurred...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28765096/effects-of-bpa-on-global-dna-methylation-and-global-histone-3-lysine-modifications-in-sh-sy5y-cells-an-epigenetic-mechanism-linking-the-regulation-of-chromatin-modifiying-genes
#10
Mine Senyildiz, Ecem Fatma Karaman, Serap Sancar Bas, Pelin Arda Pirincci, Sibel Ozden
Bisphenol A (BPA), an estrogenic endocrine disruptor, is widely used in the production of polycarbonate plastic and epoxy resins, resulting in high risk on human health. In present study we aimed to investigate the effects of BPA on global and gene specific DNA methylation, global histone modifications and regulation of chromatin modifiying enzymes in human neuroblastoma cells (SH-SY5Y). Cells were treated with BPA at 0.1, 1 and 10μM concentrations for 48 and 96h. IC50 value of BPA was determined as 183 and 129μM in SH-SY5Y cells after 24h by MTT and NRU tests, respectively...
October 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28724969/pathways-to-clinical-clarity-volumetric-analysis-of-irregular-soft-and-heterogeneous-tissues-in-development-and-disease
#11
Brian Hsueh, Vanessa M Burns, Philip Pauerstein, Katherine Holzem, Li Ye, Kristin Engberg, Ai-Chi Wang, Xueying Gu, Harini Chakravarthy, H Efsun Arda, Gregory Charville, Hannes Vogel, Igor R Efimov, Seung Kim, Karl Deisseroth
Three-dimensional tissue-structural relationships are not well captured by typical thin-section histology, posing challenges for the study of tissue physiology and pathology. Moreover, while recent progress has been made with intact methods for clearing, labeling, and imaging whole organs such as the mature brain, these approaches are generally unsuitable for soft, irregular, and heterogeneous tissues that account for the vast majority of clinical samples and biopsies. Here we develop a biphasic hydrogel methodology, which along with automated analysis, provides for high-throughput quantitative volumetric interrogation of spatially-irregular and friable tissue structures...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28722354/risk-factors-for-amputation-in-patients-with-diabetic-foot-infection-a-prospective-study
#12
Serhat Uysal, Bilgin Arda, Meltem I Taşbakan, Şevki Çetinkalp, Ilgın Y Şimşir, Anıl M Öztürk, Ayşe Uysal, İlgen Ertam
There is a variety of diagnostic and therapeutic algorithms for diabetic foot infections (DFIs). Some of them are too difficult to be applied in routine clinical approach. In the routine clinical approach, it is necessary to find new risk factors and end up with a quick and easy assessment of DFIs. In this study, we aimed to evaluate the independent risk factors for osteomyelitis, amputation and major amputation in patients with DFI using standard scoring procedures. We prospectively studied 379 patients with DFI...
July 19, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28720397/cardioprotective-effect-of-nesfatin-1-against-isoproterenol-induced-myocardial-infarction-in-rats-role-of-the-akt-gsk-3%C3%AE-pathway
#13
Arda Tasatargil, Nilay Kuscu, Selvinaz Dalaklioglu, Dileyra Adiguzel, Ciler Celik-Ozenci, Sebahat Ozdem, Ayse Barutcigil, Sadi Ozdem
The present study was designed to evaluate the cardioprotective effects of nesfatin-1, a novel peptide with anorexigenic properties, in rats with isoproterenol (ISO)-induced myocardial infarction (MI), and to further investigate the role of Akt/GSK-3β signaling pathway in the protective effect of nesfatin-1. To induce MI, ISO was subcutaneously injected into the rats for two consecutive days at a dosage of 85mg/kg/day. ISO-induced myocardial damage was indicated by elevated levels of cardiac specific troponin-T, enhanced myocardial expression of proinflammatory cytokines (interleukin-1β, interleukin-6 and tumor necrosis factor-α), and increased number of cells with apoptotic and necrotic appearance in the myocardial tissue...
July 15, 2017: Peptides
https://www.readbyqxmd.com/read/28702076/the-management-of-intra-abdominal-infections-from-a-global-perspective-2017-wses-guidelines-for-management-of-intra-abdominal-infections
#14
REVIEW
Massimo Sartelli, Alain Chichom-Mefire, Francesco M Labricciosa, Timothy Hardcastle, Fikri M Abu-Zidan, Abdulrashid K Adesunkanmi, Luca Ansaloni, Miklosh Bala, Zsolt J Balogh, Marcelo A Beltrán, Offir Ben-Ishay, Walter L Biffl, Arianna Birindelli, Miguel A Cainzos, Gianbattista Catalini, Marco Ceresoli, Asri Che Jusoh, Osvaldo Chiara, Federico Coccolini, Raul Coimbra, Francesco Cortese, Zaza Demetrashvili, Salomone Di Saverio, Jose J Diaz, Valery N Egiev, Paula Ferrada, Gustavo P Fraga, Wagih M Ghnnam, Jae Gil Lee, Carlos A Gomes, Andreas Hecker, Torsten Herzog, Jae Il Kim, Kenji Inaba, Arda Isik, Aleksandar Karamarkovic, Jeffry Kashuk, Vladimir Khokha, Andrew W Kirkpatrick, Yoram Kluger, Kaoru Koike, Victor Y Kong, Ari Leppaniemi, Gustavo M Machain, Ronald V Maier, Sanjay Marwah, Michael E McFarlane, Giulia Montori, Ernest E Moore, Ionut Negoi, Iyiade Olaoye, Abdelkarim H Omari, Carlos A Ordonez, Bruno M Pereira, Gerson A Pereira Júnior, Guntars Pupelis, Tarcisio Reis, Boris Sakakhushev, Norio Sato, Helmut A Segovia Lohse, Vishal G Shelat, Kjetil Søreide, Waldemar Uhl, Jan Ulrych, Harry Van Goor, George C Velmahos, Kuo-Ching Yuan, Imtiaz Wani, Dieter G Weber, Sanoop K Zachariah, Fausto Catena
Intra-abdominal infections (IAIs) are common surgical emergencies and have been reported as major contributors to non-trauma deaths in the emergency departments worldwide. The cornerstones of effective treatment of IAIs are early recognition, adequate source control, and appropriate antimicrobial therapy. Prompt resuscitation of patients with ongoing sepsis is of utmost important. In hospitals worldwide, non-acceptance of, or lack of access to, accessible evidence-based practices and guidelines result in overall poorer outcome of patients suffering IAIs...
2017: World Journal of Emergency Surgery: WJES
https://www.readbyqxmd.com/read/28697608/spatiotemporal-patterns-of-clinical-bovine-dermatophilosis-in-zimbabwe-1995-2014
#15
Felistas Ndhlovu, Daud N Ndhlovu, Sylvester M Chikerema, Mhosisi Masocha, Mudavanhu Nyagura, Davies M Pfukenyi
A retrospective study of clinical bovine dermatophilosis outbreaks and cases for the period 1995-2014 was conducted, using data obtained from the Division of Veterinary Services (DVS). A total of 3856 outbreaks and 26 659 cases of dermatophilosis were reported countrywide during this period. The post rainy season accounted for 37.9% of the outbreaks followed by the rainy season (26.7%), cold dry season (22.1%) and the hot dry season (13.2%). A retrospective space-time scan statistic in SaTScanTM was used to detect clusters...
June 27, 2017: Onderstepoort Journal of Veterinary Research
https://www.readbyqxmd.com/read/28679187/outcome-of-buccal-mucosa-urethroplasty-in-the-management-of-urethral-strictures
#16
Basri Cakiroglu, Orhun Sinanoglu, Ersan Arda
OBJECTIVE: The objective of the study is to report the outcome of buccal mucosal urethroplasty. MATERIALS AND METHODS: The follow up data of 15 patients undergoing single stage urethroplasty from September 2010 to September 2015 were retropectively reviewed. They received buccal mucosa graft for urethroplasty. The patients were followed for complications and outcome. RESULTS: Mean age was 53.7 ± 13.6 The stricture length ranged from 3 to 6 cm (mean 4...
June 30, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28679176/comparison-of-robotic-and-laparoscopic-partial-nephrectomy-for-small-renal-tumours
#17
Abdulmuttalip Simsek, Abdullah Hizir Yavuzsan, Yunus Colakoglu, Arda Atar, Selcuk Sahin, Volkan Tugcu
OBJECTIVE: To evaluate a single surgeon oncological and functional outcomes of laparoscopic partial nephrectomy (LPN) compared to robotic partial nephrectomy (RPN) for pT1a renal tumours. MATERIALS AND METHODS: Between 2006 and 2016, a retrospective review of 42 patients who underwent LPN (n = 20) or RPN (n = 22) by same surgeon was performed. Patients were matched for gender, age, body mass index (BMI), American Society of Anaesthesiologists (ASA) score, tumour side, RENAL and PADUA scores, peri-operative and post-operative outcomes...
June 30, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28656645/regulation-of-nuclear-receptor-interacting-protein-1-nrip1-gene-expression-in-response-to-weight-loss-and-exercise-in-humans
#18
Yang De Marinis, Jiangming Sun, Pradeep Bompada, Judit Domènech Omella, Cheng Luan, Arda Halu, Erik Renström, Amitabh Sharma, Martin Ridderstråle
OBJECTIVE: Nuclear receptor interacting protein 1 (NRIP1) is an important energy regulator, but few studies have addressed its role in humans. This study investigated adipose tissue and skeletal muscle NRIP1 gene expression and serum levels in response to weight loss and exercise in humans. METHODS: NRIP1 expression was measured by microarray and serum NRIP1 by ELISA and Western blotting. Skeletal muscle transcriptomes were analyzed from Gene Expression Omnibus databases...
August 2017: Obesity
https://www.readbyqxmd.com/read/28651625/iopromide-and-gadopentetic-acid-derived-preparates-used-in-mr-arthrography-may-be-harmful-to-chondrocytes
#19
Kadir Oznam, Duygu Yasar Sirin, Ibrahim Yilmaz, Yasin Emre Kaya, Mehmet Isyar, Seyit Ali Gumustas, Hanefi Ozbek, Semih Akkaya, Arda Kayhan, Mahir Mahirogullari
BACKGROUND: Magnetic resonance arthrography, a procedure through which contrast agents containing gadolinium and/or iopromide are administered intra-articularly, has become a useful tool in musculoskeletal diagnosis. Nevertheless, despite being considered safe for systemic use, certain tissue toxicities have been identified for both drugs. In this study, the effects of short-term exposure of human primary chondrocyte cell cultures to gadolinium and/or iopromide contrast agents were examined by assaying for stage-specific embryonic antigen-1 (SSEA-1) protein expression (a chondrogenic differentiation marker), cell viability, toxicity, and proliferation...
June 26, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28650615/selective-peptide-mediated-enhanced-deposition-of-polymer-fragrance-delivery-systems-on-human-hair
#20
Kemal Arda Günay, Damien L Berthier, Huda A Jerri, Daniel Benczédi, Harm-Anton Klok, Andreas Herrmann
The deposition of fragrance delivery systems onto human hair from a shampoo formulation is a challenging task, as the primary function of shampoo is to cleanse the hair by removing primarily hydrophobic moieties. In this work, to tackle this challenge, phage-display-identified peptides that can bind to human hair under shampooing conditions are first identified and subsequently used to enhance the deposition of model fragrance delivery systems. These delivery systems are based on either poly(N-(2-hydroxypropyl)methacrylamide) (PHPMA) copolymers as a representative for polymeric profragrances or polyurethane/polyurea-type core-shell microcapsules as a model physical fragrance carrier...
July 19, 2017: ACS Applied Materials & Interfaces
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