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https://www.readbyqxmd.com/read/28724969/pathways-to-clinical-clarity-volumetric-analysis-of-irregular-soft-and-heterogeneous-tissues-in-development-and-disease
#1
Brian Hsueh, Vanessa M Burns, Philip Pauerstein, Katherine Holzem, Li Ye, Kristin Engberg, Ai-Chi Wang, Xueying Gu, Harini Chakravarthy, H Efsun Arda, Gregory Charville, Hannes Vogel, Igor R Efimov, Seung Kim, Karl Deisseroth
Three-dimensional tissue-structural relationships are not well captured by typical thin-section histology, posing challenges for the study of tissue physiology and pathology. Moreover, while recent progress has been made with intact methods for clearing, labeling, and imaging whole organs such as the mature brain, these approaches are generally unsuitable for soft, irregular, and heterogeneous tissues that account for the vast majority of clinical samples and biopsies. Here we develop a biphasic hydrogel methodology, which along with automated analysis, provides for high-throughput quantitative volumetric interrogation of spatially-irregular and friable tissue structures...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28722354/risk-factors-for-amputation-in-patients-with-diabetic-foot-infection-a-prospective-study
#2
Serhat Uysal, Bilgin Arda, Meltem I Taşbakan, Şevki Çetinkalp, Ilgın Y Şimşir, Anıl M Öztürk, Ayşe Uysal, İlgen Ertam
There is a variety of diagnostic and therapeutic algorithms for diabetic foot infections (DFIs). Some of them are too difficult to be applied in routine clinical approach. In the routine clinical approach, it is necessary to find new risk factors and end up with a quick and easy assessment of DFIs. In this study, we aimed to evaluate the independent risk factors for osteomyelitis, amputation and major amputation in patients with DFI using standard scoring procedures. We prospectively studied 379 patients with DFI...
July 19, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28720397/cardioprotective-effect-of-nesfatin-1-against-isoproterenol-induced-myocardial-infarction-in-rats-role-of-the-akt-gsk-3%C3%AE-pathway
#3
Arda Tasatargil, Nilay Kuscu, Selvinaz Dalaklioglu, Dileyra Adiguzel, Ciler Celik-Ozenci, Sebahat Ozdem, Ayse Barutcigil, Sadi Ozdem
The present study was designed to evaluate the cardioprotective effects of nesfatin-1, a novel peptide with anorexigenic properties, in rats with isoproterenol (ISO)-induced myocardial infarction (MI), and to further investigate the role of Akt/GSK-3β signaling pathway in the protective effect of nesfatin-1. To induce MI, ISO was subcutaneously injected into the rats for two consecutive days at a dosage of 85mg/kg/day. ISO-induced myocardial damage was indicated by elevated levels of cardiac specific troponin-T, enhanced myocardial expression of proinflammatory cytokines (interleukin-1β, interleukin-6 and tumor necrosis factor-α), and increased number of cells with apoptotic and necrotic appearance in the myocardial tissue...
July 15, 2017: Peptides
https://www.readbyqxmd.com/read/28702076/the-management-of-intra-abdominal-infections-from-a-global-perspective-2017-wses-guidelines-for-management-of-intra-abdominal-infections
#4
REVIEW
Massimo Sartelli, Alain Chichom-Mefire, Francesco M Labricciosa, Timothy Hardcastle, Fikri M Abu-Zidan, Abdulrashid K Adesunkanmi, Luca Ansaloni, Miklosh Bala, Zsolt J Balogh, Marcelo A Beltrán, Offir Ben-Ishay, Walter L Biffl, Arianna Birindelli, Miguel A Cainzos, Gianbattista Catalini, Marco Ceresoli, Asri Che Jusoh, Osvaldo Chiara, Federico Coccolini, Raul Coimbra, Francesco Cortese, Zaza Demetrashvili, Salomone Di Saverio, Jose J Diaz, Valery N Egiev, Paula Ferrada, Gustavo P Fraga, Wagih M Ghnnam, Jae Gil Lee, Carlos A Gomes, Andreas Hecker, Torsten Herzog, Jae Il Kim, Kenji Inaba, Arda Isik, Aleksandar Karamarkovic, Jeffry Kashuk, Vladimir Khokha, Andrew W Kirkpatrick, Yoram Kluger, Kaoru Koike, Victor Y Kong, Ari Leppaniemi, Gustavo M Machain, Ronald V Maier, Sanjay Marwah, Michael E McFarlane, Giulia Montori, Ernest E Moore, Ionut Negoi, Iyiade Olaoye, Abdelkarim H Omari, Carlos A Ordonez, Bruno M Pereira, Gerson A Pereira Júnior, Guntars Pupelis, Tarcisio Reis, Boris Sakakhushev, Norio Sato, Helmut A Segovia Lohse, Vishal G Shelat, Kjetil Søreide, Waldemar Uhl, Jan Ulrych, Harry Van Goor, George C Velmahos, Kuo-Ching Yuan, Imtiaz Wani, Dieter G Weber, Sanoop K Zachariah, Fausto Catena
Intra-abdominal infections (IAIs) are common surgical emergencies and have been reported as major contributors to non-trauma deaths in the emergency departments worldwide. The cornerstones of effective treatment of IAIs are early recognition, adequate source control, and appropriate antimicrobial therapy. Prompt resuscitation of patients with ongoing sepsis is of utmost important. In hospitals worldwide, non-acceptance of, or lack of access to, accessible evidence-based practices and guidelines result in overall poorer outcome of patients suffering IAIs...
2017: World Journal of Emergency Surgery: WJES
https://www.readbyqxmd.com/read/28697608/spatiotemporal-patterns-of-clinical-bovine-dermatophilosis-in-zimbabwe-1995-2014
#5
Felistas Ndhlovu, Daud N Ndhlovu, Sylvester M Chikerema, Mhosisi Masocha, Mudavanhu Nyagura, Davies M Pfukenyi
A retrospective study of clinical bovine dermatophilosis outbreaks and cases for the period 1995-2014 was conducted, using data obtained from the Division of Veterinary Services (DVS). A total of 3856 outbreaks and 26 659 cases of dermatophilosis were reported countrywide during this period. The post rainy season accounted for 37.9% of the outbreaks followed by the rainy season (26.7%), cold dry season (22.1%) and the hot dry season (13.2%). A retrospective space-time scan statistic in SaTScanTM was used to detect clusters...
June 27, 2017: Onderstepoort Journal of Veterinary Research
https://www.readbyqxmd.com/read/28679187/outcome-of-buccal-mucosa-urethroplasty-in-the-management-of-urethral-strictures
#6
Basri Cakiroglu, Orhun Sinanoglu, Ersan Arda
OBJECTIVE: The objective of the study is to report the outcome of buccal mucosal urethroplasty. MATERIALS AND METHODS: The follow up data of 15 patients undergoing single stage urethroplasty from September 2010 to September 2015 were retropectively reviewed. They received buccal mucosa graft for urethroplasty. The patients were followed for complications and outcome. RESULTS: Mean age was 53.7 ± 13.6 The stricture length ranged from 3 to 6 cm (mean 4...
June 30, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28679176/comparison-of-robotic-and-laparoscopic-partial-nephrectomy-for-small-renal-tumours
#7
Abdulmuttalip Simsek, Abdullah Hizir Yavuzsan, Yunus Colakoglu, Arda Atar, Selcuk Sahin, Volkan Tugcu
OBJECTIVE: To evaluate a single surgeon oncological and functional outcomes of laparoscopic partial nephrectomy (LPN) compared to robotic partial nephrectomy (RPN) for pT1a renal tumours. MATERIALS AND METHODS: Between 2006 and 2016, a retrospective review of 42 patients who underwent LPN (n = 20) or RPN (n = 22) by same surgeon was performed. Patients were matched for gender, age, body mass index (BMI), American Society of Anaesthesiologists (ASA) score, tumour side, RENAL and PADUA scores, peri-operative and post-operative outcomes...
June 30, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28656645/regulation-of-nuclear-receptor-interacting-protein-1-nrip1-gene-expression-in-response-to-weight-loss-and-exercise-in-humans
#8
Yang De Marinis, Jiangming Sun, Pradeep Bompada, Judit Domènech Omella, Cheng Luan, Arda Halu, Erik Renström, Amitabh Sharma, Martin Ridderstråle
OBJECTIVE: Nuclear receptor interacting protein 1 (NRIP1) is an important energy regulator, but few studies have addressed its role in humans. This study investigated adipose tissue and skeletal muscle NRIP1 gene expression and serum levels in response to weight loss and exercise in humans. METHODS: NRIP1 expression was measured by microarray and serum NRIP1 by ELISA and Western blotting. Skeletal muscle transcriptomes were analyzed from Gene Expression Omnibus databases...
June 28, 2017: Obesity
https://www.readbyqxmd.com/read/28651625/iopromide-and-gadopentetic-acid-derived-preparates-used-in-mr-arthrography-may-be-harmful-to-chondrocytes
#9
Kadir Oznam, Duygu Yasar Sirin, Ibrahim Yilmaz, Yasin Emre Kaya, Mehmet Isyar, Seyit Ali Gumustas, Hanefi Ozbek, Semih Akkaya, Arda Kayhan, Mahir Mahirogullari
BACKGROUND: Magnetic resonance arthrography, a procedure through which contrast agents containing gadolinium and/or iopromide are administered intra-articularly, has become a useful tool in musculoskeletal diagnosis. Nevertheless, despite being considered safe for systemic use, certain tissue toxicities have been identified for both drugs. In this study, the effects of short-term exposure of human primary chondrocyte cell cultures to gadolinium and/or iopromide contrast agents were examined by assaying for stage-specific embryonic antigen-1 (SSEA-1) protein expression (a chondrogenic differentiation marker), cell viability, toxicity, and proliferation...
June 26, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28650615/selective-peptide-mediated-enhanced-deposition-of-polymer-fragrance-delivery-systems-on-human-hair
#10
Kemal Arda Günay, Damien L Berthier, Huda A Jerri, Daniel Benczédi, Harm-Anton Klok, Andreas Herrmann
The deposition of fragrance delivery systems onto human hair from a shampoo formulation is a challenging task, as the primary function of shampoo is to cleanse the hair by removing primarily hydrophobic moieties. In this work, to tackle this challenge, phage-display-identified peptides that can bind to human hair under shampooing conditions are first identified and subsequently used to enhance the deposition of model fragrance delivery systems. These delivery systems are based on either poly(N-(2-hydroxypropyl)methacrylamide) (PHPMA) copolymers as a representative for polymeric profragrances or polyurethane/polyurea-type core-shell microcapsules as a model physical fragrance carrier...
July 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28625222/a-small-spot-inert-gas-ion-milling-process-as-a-complementary-technique-to-focused-ion-beam-specimen-preparation
#11
Paul E Fischione, Robert E A Williams, Arda Genç, Hamish L Fraser, Rafal E Dunin-Borkowski, Martina Luysberg, Cecile S Bonifacio, András Kovács
This paper reports on the substantial improvement of specimen quality by use of a low voltage (0.05 to ~1 keV), small diameter (~1 μm), argon ion beam following initial preparation using conventional broad-beam ion milling or focused ion beam. The specimens show significant reductions in the amorphous layer thickness and implanted artifacts. The targeted ion milling controls the specimen thickness according to the needs of advanced aberration-corrected and/or analytical transmission electron microscopy applications...
June 19, 2017: Microscopy and Microanalysis
https://www.readbyqxmd.com/read/28618764/what-is-the-rectal-colonization-rate-of-carbapenem-resistant-enterobacteriaceae-cre-infected-patients-what-is-the-decolonization-rate-of-cre-colonized-patients-in-the-hospital
#12
Fatma Feriha Çilli, Bilgin Arda, Ayşe Uyan, Münevver Kayin, Demet Dikiş, Nilay Korkmaz, Nilgün Deniz Küçükler, Nurhayat Kepeli, Behiye Ulusoy, Şükran Akşit Barik, Mehmet Ali Özinel, Sercan Ulusoy, Oğuz Reşat Sipahi
No abstract text is available yet for this article.
June 12, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28613078/the-impact-of-textile-wastewater-irrigation-on-growth-and-development-of-apple-plant
#13
Hamdi Zenginbal, Gamze Dogdu Okcu, Arda Yalcuk
In this work, the effect of irrigation with textile wastewaters on the growth and development of 'Golden Delicious' apple sapling was examined over a one-year period. Municipal water prepared as a control sample (T0), 1/3 diluted (T1) and undiluted (T2) raw textile wastewater was used as the three different irrigation water samples. Two replications of each test were performed on three random samples each time. When examining the effects of T0, T1 and T2 irrigation water on plant growth, it was found that T1 irrigation water significantly increased the weight, the shoot length and the diameter of the sapling...
June 14, 2017: International Journal of Phytoremediation
https://www.readbyqxmd.com/read/28590581/bilateral-intra-areolar-polythelia
#14
Arda Isik, Deniz Firat
No abstract text is available yet for this article.
June 7, 2017: Breast Journal
https://www.readbyqxmd.com/read/28588814/coincidence-of-follicular-lymphoma-and-hurtle-cell-thyroid-carcinoma-in-a-patient-at-presentation-which-one-is-the-source-of-bone-metastasis-case-report-and-review-of-the-literature
#15
Hasan Atilla Ozkan, Arda Akoluk, Turhan Ozler, Isin Dogan Ekici, Nalan Alan Selcuk
Thyroid incidentaloma is defined as a new identified thyroid lesion occasionally detected during imaging studies. Incidence of thyroid incidentalomas is relatively rare in patients with lymphoma. Because of high rate of malignancy, these lesions with high intensity focal (18) FDG uptake detected on positron emission tomography with computed tomography (PET/CT) should undergo to biopsy regardless of size.
June 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28583483/toolkit-for-automated-and-rapid-discovery-of-structural-variants
#16
Arda Soylev, Can Kockan, Fereydoun Hormozdiari, Can Alkan
Structural variations (SV) are broadly defined as genomic alterations that affect > 50 bp of DNA, which are shown to have significant effect on evolution and disease. The advent of high throughput sequencing (HTS) technologies and the ability to perform whole genome sequencing (WGS), makes it feasible to study these variants in depth. However, discovery of all forms of SV using WGS has proven to be challenging as the short reads produced by the predominant HTS platforms (<200bp for current technologies) and the fact that most genomes include large amounts of repeats make it very difficult to unambiguously map and accurately characterize such variants...
June 2, 2017: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/28538449/sonographic-and-magnetic-resonance-imaging-characteristics-of-juvenile-papillomatosis-three-cases-with-different-manifestations
#17
Ravza Yilmaz, Zuhal Bayramoglu, Fuat Bicen, Arda Kayhan, Semen Yesil, Gulden Acunas
Juvenile papillomatosis (JP) is an infrequently seen benign proliferative lesion in women younger than 30 years. Herein, we present different clinical manifestations of histopathologically proven JP of the breast, in addition to magnetic resonance and sonographic imaging features of these cases. Patient 1 exhibited nipple discharge and papillary carcinoma accompanied after the operation. Patient 2 presented with a giant mass with cystic and numerous solid nodular components that filled the entire right breast...
June 2017: Ultrasound Quarterly
https://www.readbyqxmd.com/read/28528610/targeted-treatment-of-atopic-dermatitis
#18
Simon Arda Metin, Marc Wallace
No abstract text is available yet for this article.
2017: Skinmed
https://www.readbyqxmd.com/read/28490163/effects-of-quercetin-and-mannitol-on-erythropoietin-levels-in-rats-following-acute-severe-traumatic-brain-injury
#19
Orhan Kalemci, Hasan Emre Aydin, Ceren Kizmazoglu, Ismail Kaya, Hulya Yılmaz, Nuri M Arda
OBJECTIVE: The aim of this study to investigate the normal values of erythropoietin (EPO) and neuroprotective effects of quercetin and mannitol on EPO and hematocrit levels after acute severe traumatic brain injury (TBI) in rat model. METHODS: A weight-drop impact acceleration model of TBI was used on 40 male Wistar rats. The animals were divided into sham (group I), TBI (group II), TBI+quercetin (50 mg/kg intravenously) (group III), and TBI+mannitol (1 mg/kg intravenously) (group IV) groups...
May 2017: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/28488787/nitrotoga-is-selected-over-nitrospira-in-newly-assembled-biofilm-communities-from-a-tap-water-source-community-at-increased-nitrite-loading
#20
Marta Kinnunen, Arda Gülay, Hans-Jørgen Albrechtsen, Arnaud Dechesne, Barth F Smets
Community assembly is a central topic in microbial ecology: how do assembly processes interact and what is the relative contribution of stochasticity and determinism? Here, we exposed replicate flow-through biofilm systems, fed with nitrite-supplemented tap water, to continuous immigration from a source community, present in the tap water, to determine the extent of selection and neutral processes in newly assembled biofilm communities at both the community and the functional guild (of nitrite-oxidizing bacteria, NOB) levels...
May 10, 2017: Environmental Microbiology
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