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https://www.readbyqxmd.com/read/29158347/pillars-article-requirement-for-the-transcription-factor-lsirf-irf4-for-mature-b-and-t-lymphocyte-function-science-1997-275-540-543
#1
Hans-Willi Mittrücker, Toshifumi Matsuyama, Alex Grossman, Thomas M Kündig, Julia Potter, Arda Shahinian, Andrew Wakeham, Bruce Patterson, Pamela S Ohashi, Tak W Mak
No abstract text is available yet for this article.
December 1, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29156865/antibacterial-resistance-patterns-and-incidence-of-hospital-acquired-staphylococcus-aureus-bacteremia-in-a-tertiary-care-educational-hospital-in-turkey-a-perspective-from-2001-to-2013
#2
Oğuz Reşat Sipahi, Serhat Uysal, Sabire Şöhret Aydemir, Hüsnü Pullukçu, Meltem Taşbakan, Alper Tünger, Fatma Feriha Çilli, Tansu Yamazhan, Bilgin Arda, Hilal Sipahi, Sercan Ulusoy
Background/aim: Staphylococcus aureus is an important nosocomial pathogen and a successful antimicrobial-resistance developer. In this study we retrospectively evaluated the resistance patterns and incidence of microbiologically confirmed nosocomial bacteremia (MCNB) related S. aureus strains between 2001 and 2013. Materials and methods: Any patient in whom S. aureus was isolated in at least one set of blood cultures (sent to the bacteriology laboratory 72 h after hospital admission) was considered to have MCNB...
August 23, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29151329/epidemiology-and-analysis-of-invasive-fungal-infections-in-patients-withhematological-malignancies-a-single-center-real-life-experience
#3
Nur Soyer, Hatice Demet Kiper Ünal, Filiz Vural, Fahri Şahin, Mahmut Töbü, Ayhan Dönmez, Murat Tombuloğlu, Bilgin Arda, Güray Saydam
Background/aim: Invasive fungal infection (IFI) causes morbidity and mortality among patients with hematological malignancies. We evaluated the incidence and treatment characteristics of IFIs between October 2012 and December 2013. Materials and methods: Patients who received chemotherapy or stem cell transplantation were retrospectively evaluated. Fungal infections were classified according to EORTC criteria.Results: Prophylaxis and antifungal therapy were given in 30.5% and 23.6% of 522 chemotherapy courses, respectively...
November 13, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29104343/low-intensity-pulsed-ultrasound-lipus-for-the-treatment-of-intervertebral-disc-degeneration
#4
Devante Horne, Peter Jones, Vasant Salgaonkar, Matt Adams, B Arda Ozilgen, Peter Zahos, Xinyan Tang, Ellen Liebenburg, Dezba Coughlin, Jeffrey Lotz, Chris Diederich
Discogenic back pain presents a major public health issue, with current therapeutic interventions limited to short-term symptom relief without providing regenerative remedies for diseased intervertebral discs (IVD). Many of these interventions are invasive and can diminish the biomechanical integrity of the IVDs. Low intensity pulsed ultrasound (LIPUS) is a potential treatment option that is both non-invasive and regenerative. LIPUS has been shown to be a clinically effective method for the enhancement of wound and fracture healing...
January 2017: Proceedings of SPIE
https://www.readbyqxmd.com/read/29067040/long-term-outcomes-of-laparoscopic-and-open-modified-lich-gregoir-reimplantation-in-adults-a-multicentric-comparative-study
#5
Arda Atar, Mithat Eksi, Ahmet Faysal Güler, Murat Tuncer, Fatih Akkas, Volkan Tugcu
BACKGROUND & OBJECTIVE: Obstructive ureteral pathologies in adult patients are most commonly due to ureteral strictures and secondary to surgical interventions. In this study, we aimed to compare open and laparoscopic modified Lich-Gregoir ureteral reimplantation with regards to outcomes in benign ureteral pathologies in adult patients. METHODS: Between December 2008 and December 2014, 32 open cases and 29 laparoscopic cases were performed as per the data retrieved from surgical databases...
July 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29060009/ultrasonic-thermal-dust-a-method-to-monitor-deep-tissue-temperature-profiles
#6
B Arda Ozilgen, Michel M Maharbiz
We demonstrate a tetherless, sub-millimeter implantable temperature sensing system employing ultrasonic powering and ultrasonic backscatter modulation assembled using commercially available components. We demonstrate two sizes of sensors based on available components with volumes of 1.45 mm(3) and 0.118 mm(3). Individual sensors are able to resolve ±0.5°C changes in temperature, suitable for medical diagnostic and monitoring purposes. We verify less than 0.3°C drift in temperature readings over 14 days in physiological conditions...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29058819/involvement-of-dying-beta-cell-originated-messenger-molecules-in-differentiation-of-pancreatic-mesenchymal-stem-cells-under-glucotoxic-and-glucolipotoxic-conditions
#7
Selda Gezginci-Oktayoglu, Evren Onay-Ucar, Serap Sancar-Bas, Ayse Karatug-Kacar, Emine Sekure Nazli Arda, Sehnaz Bolkent
Beta cell mass regulation represents a critical issue for understanding and treatment of diabetes. The most important process in the development of diabetes is beta cell death, generally induced by glucotoxicity or glucolipotoxicity, and the regeneration mechanism of new beta cells that will replace dead beta cells is still not fully understood. The aim of this study was to investigate the generation mechanism of new beta cells by considering the compensation phase of type2 diabetes mellitus. Pancreatic islet derived mesenchymal stem cells (PI-MSCs) were isolated from adult rats and characterized...
October 23, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29055829/density-and-distribution-of-nitrifying-guilds-in-rapid-sand-filters-for-drinking-water-production-dominance-of-nitrospira-spp
#8
Karolina Tatari, Sanin Musovic, Arda Gülay, Arnaud Dechesne, Hans-Jørgen Albrechtsen, Barth F Smets
We investigated the density and distribution of total bacteria, canonical Ammonia Oxidizing Bacteria (AOB) (Nitrosomonas plus Nitrosospira), Ammonia Oxidizing Archaea (AOA), as well as Nitrobacter and Nitrospira in rapid sand filters used for groundwater treatment. To investigate the spatial distribution of these guilds, filter material was sampled at four drinking water treatment plants (DWTPs) in parallel filters of the pre- and after-filtration stages at different locations and depths. The target guilds were quantified by qPCR targeting 16S rRNA and amoA genes...
October 10, 2017: Water Research
https://www.readbyqxmd.com/read/29027818/effects-of-nesfatin-1-on-atrial-contractility-and-thoracic-aorta-reactivity-in-male-rats
#9
Ayşe Barutcigil, Arda Tasatargil
BACKGROUND: This study aimed to examine the effects of nesfatin-1 on thoracic aorta vasoreactivity and to investigate the inotropic and chronotropic effects of nesfatin-1 on the spontaneous contractions of the isolated rat atria. METHODS: Isolated right atria and thoracic aorta were used in organ baths. The reactivity of the thoracic aorta was evaluated by potassium chloride (KCl), phenylephrine (Phe), acetylcholine (ACh), and sodium nitroprusside (SNP). The effects of nesfatin-1 on the spontaneous contractions of the rat atria were also examined...
October 13, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29027695/shear-wave-elastographic-alterations-in-the-kidney-after-extracorporeal-shock-wave-lithotripsy
#10
Rustu Turkay, Ercan Inci, Derya Bas, Arda Atar
OBJECTIVES: Extracorporeal shock wave lithotripsy (ESWL) is a method used frequently for the treatment of renal stone disease. Although its safety is proven, there are still concerns about its unwanted effects on kidneys. In this prospective study, we aimed to evaluate renal tissue alterations with shear wave elastography (SWE) after ESWL. We also studied the correlation between SWE and resistive index (RI) changes. METHODS: The study included 59 patients who underwent ESWL treatment for renal stone disease...
October 13, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29025589/potential-circulating-mirna-signature-for-early-detection-of-nsclc
#11
Ayda Arab, Morteza Karimipoor, Shiva Irani, Arda Kiani, Sirous Zeinali, Elham Tafsiri, Kambiz Sheikhy
Circulating microRNAs (c-miRNAs) are promising biomarkers for screening, early detection and prognosis of cancer. The purpose of this investigation was to identify a panel of c-miRNAs in plasma that could contribute to early detection of non-small cell lung cancer (NSCLC). We profiled the expression of 44 unique plasma miRNAs in training set of 34 NSCLC patients and 20 matched healthy individuals by miRCURY LNA™ Universal RT microRNA PCR Panel and calculated dysregulation fold changes using the 2-ΔΔCt equation...
October 2017: Cancer Genetics
https://www.readbyqxmd.com/read/28976340/effects-of-keratinocytes-differentiated-from-embryonic-and-adipogenic-stem-cells-on-wound-healing-in-a-diabetic-mouse-model
#12
Bilgin Arda, Serhat Uysal, Meltem Taşbakan, Ilgın Yıldırım Şimşir, Murat Öztürk, İlgen Ertam, Ayşe Uysal, Sercan Ulusoy
OBJECTIVE: The aim of this study is to evaluate tigecycline for diabetic foot infections (DFIs). MATERIALS AND METHODS: In this prospective observational study, the investigators included patients who had consultation with the Diabetic Foot Council of Ege University Faculty of Medicine (Izmir, Turkey) between March 2013 and July 2015 and who used tigecycline during their treatment. Treatment success was assessed by design-specific criteria for each evaluation. RESULTS: The study included 105 cases...
November 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28969400/single-plus-one-port-robotic-radical-prostatectomy-sporp-initial-experience
#13
Volkan Tugcu, Abdulmuttalip Simsek, Ismail Evren, Kamil Gokhan Seker, Ramazan Kocakaya, Bugra Dogukan Torer, Arda Atar, Ali Ihsan Tasci
OBJECTIVE: This article reports on patients with early stage prostate cancer treated with single plus one port robotic radical prostatectomy (SPORP). MATERIALS AND METHODS: Since January 2014, we performed SPORP in 8 patients with localized prostate cancer. Age of patients, clinical stage, operation time, intraoperative and postoperative complications, blood loss, histopathological evaluation, postoperative continence, serum level of PSA were evaluated. RESULTS: Mean age of the 8 patients was 59...
October 3, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28965763/single-cell-analysis-of-human-pancreas-reveals-transcriptional-signatures-of-aging-and-somatic-mutation-patterns
#14
Martin Enge, H Efsun Arda, Marco Mignardi, John Beausang, Rita Bottino, Seung K Kim, Stephen R Quake
As organisms age, cells accumulate genetic and epigenetic errors that eventually lead to impaired organ function or catastrophic transformation such as cancer. Because aging reflects a stochastic process of increasing disorder, cells in an organ will be individually affected in different ways, thus rendering bulk analyses of postmitotic adult cells difficult to interpret. Here, we directly measure the effects of aging in human tissue by performing single-cell transcriptome analysis of 2,544 human pancreas cells from eight donors spanning six decades of life...
October 5, 2017: Cell
https://www.readbyqxmd.com/read/28957117/heterodyne-locking-of-a-fully-integrated-optical-phase-locked-loop-with-on-chip-modulators
#15
Shamsul Arafin, Arda Simsek, Mingzhi Lu, Mark J Rodwell, Larry A Coldren
We design and experimentally demonstrate a highly integrated heterodyne optical phase-locked loop (OPLL) consisting of an InP-based coherent photonic receiver, high-speed feedback electronics, and an RF synthesizer. Such coherent photonic integrated circuits contain two widely tunable lasers, semiconductor optical amplifiers, phase modulators, and a pair of balanced photodetectors. Offset phase-locking of the two lasers is achieved by applying an RF signal to an on-chip optical phase modulator following one of the lasers and locking the other one to a resulting optical sideband...
October 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28953646/botulinum-toxin-in-the-treatment-of-trigeminal-neuralgia-6-month-follow-up
#16
Ülkü Türk Börü, Arda Duman, Cem Bölük, Sanem Coşkun Duman, Mustafa Taşdemir
BACKGROUND: Botulinum toxin type-A (BTX-A) has been successfully utilized to treat trigeminal neuralgia. In this study, through the use of a new technique, the efficacy of the injection of BTX-A to the maxillary and mandibular nerves was evaluated. METHODS: A total of 27 patients were injected with 100 Units of BTX-A to the maxillary and mandibular nerves. Visual analogue scale score and pain frequency were assessed before treatment and at the first week, second month, and sixth month after treatment...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28925338/foraging-behaviour-of-the-exotic-wasp-vespula-germanica-hymenoptera-vespidae-on-a-native-caterpillar-defoliator
#17
A L Pietrantuono, S Moreyra, M Lozada
Vespula germanica is a social wasp and an opportunistic predator. While foraging, these wasps learn and integrate different kinds of cues. They have successfully invaded many parts of the world, including native Nothofagus and Lophozonia forests located in the Andean-Patagonian region, where they forage on native arthropods. Perzelia arda, a lepidopteron defoliator of Lophozonia obliqua, uses the foliage to hide in and feed on. The purpose of this work is to study whether V. germanica use olfactory cues when foraging on P...
September 19, 2017: Bulletin of Entomological Research
https://www.readbyqxmd.com/read/28916031/dermatosis-papulosa-nigra-a-clinically-and-histopathologically-distinct-entity
#18
Simon Arda Metin, Brian W Lee, William Clark Lambert, Lawrence Charles Parish
Dermatosis papulosa nigra was first described by Aldo Castellani (1874-1971) more than 90 years ago, and it has since been presumed to be a variant of seborrheic keratosis. Despite their morphologic similarities both macroscopically and microscopically, key differences have yet to be explained. These lesions also exhibit different demographics, with dermatosis papulosa nigra having a predilection for dark-skinned individuals and a female predominance. No studies to date have investigated this, but studies assessing the mechanisms of similar dermatologic conditions may yield significant clues...
September 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/28894850/cost-effectiveness-of-breast-cancer-screening-in-turkey-a-developing-country-results-from-bah%C3%A3-e%C3%A5-ehir-mammography-screening-project
#19
Vahit Özmen, Sibel Ö Gürdal, Neslihan Cabioğlu, Beyza Özcinar, A Nilüfer Özaydın, Arda Kayhan, Erkin Arıbal, Cennet Sahin, Pınar Saip, Oğuzhan Alagöz
OBJECTIVE: We used the results from the first three screening rounds of Bahcesehir Mammography Screening Project (BMSP), a 10-year (2009-2019) and the first organized population-based screening program implemented in a county of Istanbul, Turkey, to assess the potential cost-effectiveness of a population-based mammography screening program in Turkey. MATERIALS AND METHODS: Two screening strategies were compared: BMSP (includes three biennial screens for women between 40-69) and Turkish National Breast Cancer Registry Program (TNBCRP) which includes no organized population-based screening...
July 2017: Eur J Breast Health
https://www.readbyqxmd.com/read/28893946/a-radial-axis-defined-by-semaphorin-to-neuropilin-signaling-controls-pancreatic-islet-morphogenesis
#20
Philip T Pauerstein, Krissie Tellez, Kirk B Willmarth, Keon Min Park, Brian Hsueh, H Efsun Arda, Xueying Gu, Haig Aghajanian, Karl Deisseroth, Jonathan A Epstein, Seung K Kim
The islets of Langerhans are endocrine organs characteristically dispersed throughout the pancreas. During development, endocrine progenitors delaminate, migrate radially and cluster to form islets. Despite the distinctive distribution of islets, spatially localized signals that control islet morphogenesis have not been discovered. Here, we identify a radial signaling axis that instructs developing islet cells to disperse throughout the pancreas. A screen of pancreatic extracellular signals identified factors that stimulated islet cell development...
October 15, 2017: Development
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