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https://www.readbyqxmd.com/read/29777891/surgical-strategy-for-and-anatomical-locations-of-petroapex-and-petroclival-meningiomas-based-on-evaluation-of-the-feeding-artery
#1
Kazuhide Adachi, Mituhiro Hasegawa, Shinichiro Tateyama, Yushi Kawazoe, Yuichi Hirose
OBJECTIVE: The anterior transpetrosal (ATP) approach is the most appropriate approach for petroclival meningiomas, which are typically located from the dorsum sellae to the upper border of the internal acoustic meatus (IAM). Although neurosurgeons can resect over this area if the tumor is detached from the dura, tumors within the indication area for petroclival meningiomas is insufficient for the selection of the ATP approach because it can be difficult to evaluate whether the tumor is attached or only touching the dura...
May 16, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29771093/-pharyngeal-space-carcinoma-ex-pleomorphic-adenoma%C3%AF-a-case-report
#2
Y L Jiang, H S Peng, S H Wu, X H Xie, X H Zhu, Y H Liu
Carcinoma ex pleomorphic adenoma is an epithelial malignant tumor of pleomorphic adenoma. This may be due to the accumulation of genetic instability caused by long-term pleomorphic adenomas. There are few reports of parapharyngeal space carcinoma ex pleomorphic adenoma in the literature study both at home and abroad. This article retrospectively summarized the clinical data of 1 case of pharyngeal space carcinoma ex pleomorphic adenoma and reviewed the literature. We strengthened the understanding of parapharyngeal space carcinoma ex pleomorphic adenoma, improve the accuracy of diagnosis and reduce misdiagnosis and mistreatment...
May 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29771050/-fibrous-hemangioma-of-esophagus-portal-a-case-report
#3
Y P Wang, L X Li
A 33 year old male patient has found in the oral cavity tumor with nausea and vomiting after 20 days ago. The patients feel pharyngeal foreign body sensation, occasional sense of suffocation, the oropharyngeal tumor disappeared and foreign body sensation disappeared after swallowing. The patients without angina, no hemoptysis, no hoarseness, no acid reflux symptoms and weight loss phenomenon. The gastroscope showed giant tumor, esophagus smooth surface, visible local gray blue blood vessels, from the entrance of esophagus has been extended to the esophagus from the upper incisors 25 cm...
May 20, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29771043/-the-effect-of-tanshinone-%C3%A2-a-potentiates-the-effects-of-cisplatin-in-fadu-cells-in-vitro-through-downregulation-of-survivin
#4
Y X Zhao, D Luo, Y H Zhang, B Shen, B X Wang, Z F Sun
Objective: The aim of this study is to investigate the inhibitory effect and mechanism of tanshinone ⅡA combined with cisplatin on tumor Fadu cells in pharyngeal squamous cell carcinoma. Method: Cytotoxicity was determined by CCK8 assay. Flow cytometry was used to detect apoptosis and cell cycle distribution. Western blotting was used to assess the protein expression of related signaling proteins. Result: Compared with the two single drug groups treated with Tan ⅡA and DDP respectively, the combination group showed significantly higher anti-proliferative rate ( P <0...
May 20, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29765820/a-comparative-analysis-of-endoscopic-assisted-transoral-and-transnasal-approaches-to-parapharyngeal-space-a-cadaveric-study
#5
Xicai Sun, Bo Yan, Huy Q Truong, Hamid Borghei-Razavi, Carl H Snyderman, Juan C Fernandez-Miranda
Background  Surgical resection of parapharyngeal space (PPS) tumors is very challenging. An endoscopic-assisted surgical approach to this region requires detailed and precise anatomic knowledge. The main purpose of this study is to describe and compare the detailed anatomy of the PPS via transnasal transpterygoid (TP) and endoscopic-assisted transoral (TO) approaches. Materials and Methods  Six fresh injected cadaver heads (12 sides) were prepared for dissection of the PPS via TP and TO approaches. Computed tomography (CT) with image-based navigation (Navigation System II; Stryker, Kalamazoo, Michigan, United States) was used to identify bony structures around the PPS...
June 2018: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/29764017/-significance-of-retropharyngeal-node-dissection-in-treatment-of-hypopharyngeal-carcinoma
#6
Z H Lyu, W Xu, N Sa, J K Ma, J J Tian, S H Feng, H Y Cao
Objective: investigate the incidence of retropharyngeal lymph node (RPLN) metastasis and the risk factors for RPLN metastasis in hypopharyngeal cancer, and the relationship of planned dissection of the RPLN with the survival and tumor control rates in patients with hypopharyngeal cancer. Methods: A total of 203 patients with hypopharyngeal squamous cell carcinoma who underwent radical surgery as initial treatment from February 2011 to July 2015 were analyzed retrospectively. There were 167 cases of pyriform sinus carcinoma, 23 cases of posterior pharyngeal wall carcinoma, and 13 cases of postcricoid carcinoma...
May 7, 2018: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/29751190/preoperative-embolization-of-skull-base-meningiomas-outcomes-in-the-onyx-era
#7
Colin J Przybylowski, Jacob F Baranoski, Alfred P See, Bruno C Flores, Rami O Almefty, Dale Ding, Kristina M Chapple, Nader Sanai, Andrew F Ducruet, Felipe C Albuquerque
OBJECTIVE: Preoperative embolization may facilitate skull base meningioma resection, but its safety and efficacy in the Onyx era have not been investigated. In this retrospective cohort study, we evaluated the outcomes of preoperative embolization of skull base meningiomas using Onyx as the primary embolysate. METHODS: We queried an endovascular database for patients with skull base meningiomas who underwent preoperative embolization at our institution in 2007-2017...
May 8, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29747255/-endoscopic-screening-for-upper-gastrointestinal-second-primary-malignancies-in-patients-with-hypopharyngeal-squamous-cell-carcinoma
#8
J J Tian, W Xu, Z H Lyu, J K Ma, P Cui, N Sa, H Y Cao
Objective: To evaluate the usefullness of flexible esophagoscopy and chromoendoscopy with Lugol's solution in the detection of synchronous esophageal neoplasm in patients with hypopharyngeal squamous cell carcinoma (HSCC). Methods: A retrospective review of 96 cases with HSCC that received surgical treatment from March 2016 to March 2017 was accomplished. In these patients, the site of origin were pyriform sinus ( n =75), posterior pharyngeal wall ( n =11) and postcricoid ( n =10). Esophagoscopy was prospectively performed on all patients before treatment for HSCC...
April 7, 2018: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/29731889/swallowing-disorder-following-salvage-total-pharyngo-laryngo-esophagectomy-with-free-jejunum-reconstruction
#9
Takashi Maruo, Minoru Sakuraba, Takeshi Shinozaki, Toshifumi Tomioka, Wataru Okano, Satoko Arahira, Yoshie Iino, Ryuichi Hayashi
For recurrent cases or residual cases following concomitant chemo-radiation therapy (CCRT), salvage surgery is a frequently used treatment options. A swallowing disorder is one of the major complications of CCRT. The purpose of the present study was to evaluate the effect of CCRT on swallowing function in patients who underwent salvage total pharyngo-laryngo-esophagectomy (TPLE), and to evaluate the importance of pharyngeal constriction in patients who underwent TPLE. Between 2008 January and 2014 May, 54 patients were treated with salvage TPLE following CCRT or TPLE at the National Cancer Center Hospital East, Chiba, Japan and were included in the present study...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29721187/total-lesion-glycolysis-on-fdg-pet-ct-before-salvage-surgery-predicts-survival-in-laryngeal-or-pharyngeal-cancer
#10
Hidenori Suzuki, Tsuneo Tamaki, Masami Nishio, Yusuke Nakata, Nobuhiro Hanai, Daisuke Nishikawa, Yusuke Koide, Yasuhisa Hasegawa
We investigated whether 18F-fluorodeoxyglucose uptake parameters using positron emission tomography combined with computed tomography predicts several survival outcomes, including lung metastasis-free survival, in patients with laryngeal or pharyngeal cancer who underwent salvage surgery. The maximum standardized uptake value, metabolic tumor volume, and total lesion glycolysis were calculated as 18F-fluorodeoxyglucose uptake parameters in 51 patients with laryngeal or pharyngeal cancer before salvage surgery...
April 10, 2018: Oncotarget
https://www.readbyqxmd.com/read/29693014/epithelial-mesenchymal-transition-during-metastasis-of-hpv-negative-pharyngeal-squamous-cell-carcinoma
#11
Friedrich Ihler, Ronja Gratz, Hendrik A Wolff, Bernhard G Weiss, Mattis Bertlich, Julia Kitz, Gabriela Salinas, Margret Rave-Fränk, Martin Canis
In epithelial tumors, a shift towards a mesenchymal phenotype has been associated with increased invasiveness and metastasis. It is assumed that this phenomenon plays a major role in disease progression and ultimately prognosis. This study investigated epithelial-mesenchymal transition (EMT) in human papillomavirus- (HPV-) negative pharyngeal squamous cell carcinoma. Tissue was obtained from one hypopharyngeal primary tumor and a regional lymph node metastasis during surgery with curative intention. A cell culture was established from the primary tumor and mesenchymal growth conditions were emulated...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29663604/primary-extracranial-nasopharyngeal-meningioma-in-a-dog
#12
Emilie Fauchon, Jean-Charles Husson, Juan Hernandez, Eymeric Gomes
An 8-year-old Labrador Retriever was presented for inspiratory efforts with stertor. A rhinoscopy and a magnetic resonance imaging scan were performed and revealed a naso-pharyngeal mass. The mass was identified in the nasopharynx without meningeal extension. This mass was both T1- and T2-hyperintense, compared to normal brain parenchyma without significant postcontrast enhancement. The mass was surgically removed and the histologic diagnosis was a mesenchymal tumor. Immunohistochemistry with antibodies was conducted and consistent with an extracranial meningioma...
April 16, 2018: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/29643997/new-antimicrobial-peptide-kills-drug-resistant-pathogens-without-detectable-resistance
#13
Jong-Kook Lee, Tudor Luchian, Yoonkyung Park
Clavaspirin peptide (CSP) is derived from the pharyngeal tissues of the tunicate Styela clava . The 23-amino acid peptide is histidine-rich and amidated at the N-terminus. CSP possesses low antimicrobial and high hemolytic activity at pH 7.4. Therefore, we designed 4 CSP analogs with substituted hydrophobic amino acids to reduce hydrophobic amino acid interactions. These modifications reduced the aggregation and cytotoxicity of the analogs at pH 7.4. The analogs also showed potent antimicrobial activity by accumulating on bacterial cell surfaces and inducing the lytic mechanism against gram-negative and gram-positive cells at pH 5...
March 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29611769/predictors-of-complications-in-patients-receiving-head-and-neck-free-flap-reconstructive-procedures
#14
Antoine Eskander, Stephen Kang, Ben Tweel, Jigar Sitapara, Matthew Old, Enver Ozer, Amit Agrawal, Ricardo Carrau, James W Rocco, Theodoros N Teknos
Objective To (1) determine the overall complication rate, wound healing, and wound infection complications and (2) identify preoperative, intraoperative, and postoperative predictors of these complications. Study Design Case series with chart review. Setting Tertiary academic cancer hospital. Subjects and Methods All head and neck free flap patients at The Ohio State University (2006-2012) were assessed. Multivariable logistic regression assessed the impact of patient factors, flap and wound factors, and intraoperative factors on the aforementioned quality metric outcomes...
April 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29594240/skull-base-or-cervical-vertebral-osteomyelitis-following-chemoradiotherapy-for-pharyngeal-carcinoma-a-serious-but-treatable-complication
#15
Nafisha Lalani, Shao Hui Huang, Coleman Rotstein, Eugene Yu, Jonathan Irish, Brian O'Sullivan
Osteomyelitis, infection of the bone and marrow, following high dose (chemo-)radiotherapy for head and neck cancer is uncommon and rarely seen in the cervical spine or temporal bone. Due to its proximity to critical structures, osteomyelitis in the latter regions could carry potentially important consequences. Furthermore, involvement near the skull base (e.g. temporal bone and high cervical vertebrae) presents unique challenges in diagnosis (especially in the differentiation from disease recurrence) and treatment, making early detection and timely intervention critical...
January 2018: Clinical and translational radiation oncology
https://www.readbyqxmd.com/read/29573005/bocca-s-hemipharyngo-total-laryngectomy-for-hypopharyngeal-carcinoma-to-avoid-reconstruction-with-a-pedicled-flap
#16
Marco Lucioni, Marco Lionello, Gianni Salis, Andy Bertolin, Giuseppe Rizzotto
BACKGROUND: Major pharyngeal defects after total pharyngolaryngectomy for hypopharyngeal squamous cell carcinoma (SCC) frequently demand reconstruction strategies that include myocutaneous pedicled flaps, such as the pectoralis major flap. METHODS: We retrospectively reviewed the clinical charts of 24 patients with hypopharyngeal SCC treated with Bocca's hemipharyngo-total laryngectomy (HPTL) at our Institution. RESULTS: Eighteen patients (80%) experienced no disease recurrence after primary surgery and were alive with no evidence of disease after a mean follow-up of 43 months...
March 23, 2018: Head & Neck
https://www.readbyqxmd.com/read/29552173/multi-institutional-survey-of-carotid-body-tumors-in-japan
#17
Aya Ikeda, Kiyoto Shiga, Katsunori Katagiri, Daisuke Saito, Jun Miyaguchi, Shin-Ichi Oikawa, Kodai Tsuchida, Takahiro Asakage, Hiroyuki Ozawa, Ken-Ichi Nibu, Naoki Ohtsuki, Yasushi Fujimoto, Ken-Ichi Kaneko
There has been no attempt to clarify the status of patients with carotid body tumor (CBT) in Japan. This multi-institutional survey analyzed patients with CBT throughout Japan by gathering information on these patients from institutions that performed head and neck surgeries. Information from a total of 150 patients from 25 institutions from the past 20 years was employed in the present survey. There were 87 females and 63 males, and their mean age was 48.0 years old. The most common chief complaint was a neck mass and the mean suffering period was 46...
April 2018: Oncology Letters
https://www.readbyqxmd.com/read/29534352/-clinicopathologic-characteristics-and-prognositic-indicators-of-tonsillar-mantle-cell-lymphoma
#18
W H Hou, P Wei, J L Xie, Y Y Zheng, Y L Zhang, X G Zhou
Objective: To investigate clinicopathological features and prognosis of tonsillar mantle cell lymphoma(TMCL). Methods: Clinical data of 25 patients with TMCL at Beijing Friendship Hospital, Capital Medical University from 2002 to 2016 were included. All the cases were reviewed microscopically. Various immunohistochemical stains were performed using the MaxVision two-step method. IgH/CCND1 gene fusion was detected by fluorescent in situ hybridization(FISH). Additionally, randomly selected 40 cases of non-tonsil MCL of the same period were compared...
March 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29494399/clinicopathologic-characteristics-of-thyroid-like-low-grade-nasopharyngeal-papillary-adenocarcinoma-a-case-report
#19
Liang Li, Fengjuan Zhou, Fanzhong Lin, Cuihong Han
Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma (TL-LGNPPA) is an extremely rare neoplasm. It morphologically resembles papillary thyroid carcinoma and is immunochemically positive for thyroid transcription factor 1. Herein, we reported a case of TL-LGNPPA in a female patient of 35 years old. She felt pharyngeal foreign body sensation of unknown cause and subsequently developed dyspnea after activities. Nasopharyngeal plain computerized tomography showed no abnormalities, but laryngoscopy showed a peanut-sized smooth neoplasm with a pedicel at the posterior edge of the nasal septum...
February 28, 2018: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/29408295/kir2ds1-2ds5-3ds1-and-kir2dl5-are-associated-with-the-risk-of-head-and-neck-squamous-cell-carcinoma-in-iranians
#20
Shaghik Barani, Bijan Khademi, Elham Ashouri, Abbas Ghaderi
BACKGROUND: Activating and inhibitory KIR receptors (aKIR, iKIR) control the development and function of NK cells whose function alterations adjust the tumor microenvironment immunity. This research was conducted to determine the KIRs gene impact on genetic predisposition to Head and Neck Squamous Cell Carcinoma (HNSCC) in Iranians. METHODS: KIR genotyping using sequence-specific primers-polymerase chain reaction (SSP-PCR) method was performed to identify the presence of all 16 KIR genes in 285 HNSCC patients, including laryngeal, oral cavity and pharyngeal SCC and 273 controls (CNs)...
April 2018: Human Immunology
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