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pharyngeal tumor

Huei-Tzu Chien, Sou-De Cheng, Wen-Yu Chuang, Chun-Ta Liao, Hung-Ming Wang, Shiang-Fu Huang
Amplification of 11q13.3 is a frequent event in human cancers, including head and neck squamous cell carcinoma. This chromosome region contains several genes that are potentially cancer drivers, including FADD (Fas associated via death domain), an apoptotic effector that was previously identified as a novel oncogene in laryngeal/pharyngeal cancer. This study was designed to explore the role of FADD in oral squamous cell carcinomas (OSCCs) samples from Taiwanese patients, by assessing copy number variations (CNVs) and protein expression and the clinical implications of these factors in 339 male OSCCs...
2016: PloS One
Ying-Chun Lin, Rui-Yun Chen, Shang-Wen Chen, Te-Chun Hsieh, Kuo-Yang Yen, Ji-An Liang, Shih-Neng Yang, Yao-Ching Wang, Ya-Huey Chen, Nan-Haw Chow, Chia-Hung Kao
OBJECTIVES: This study correlated immunohistochemical studies with fluorodeoxyglucose (FDG) uptake on positron emission tomography-computed tomography (PET-CT) and identified prognostic factors for radiotherapy (RT)-based treatment outcomes in patients with squamous cell carcinoma of the oropharynx and hypopharynx. METHODS: Genomic data from pretreatment biopsy specimens (Glut1, CAIX, VEGF, HIF-1α, EGFR, Ki-67, Bcl-2, CLAUDIN-4, YAP-1, c-Met, and p16) of 76 patients were analyzed using tissue microarrays...
October 20, 2016: Clinical Otolaryngology
F Bootz, S Greschus, T van Bremen
The parapharyngeal space extends from the nasopharynx to the oropharynx. It is bordered medially by the pharyngeal wall and the constrictor pharyngis muscles, and laterally by the mandible. One distinguishes between a pre- and a poststyloid space. Tumors of the parapharyngeal space are rare and represent less than 1 % of all head and neck neoplasms. Benign (70-80 %) as well as malignant (20-30 %) tumors arise from different structures of the parapharyngeal space, mainly from salivary glands and nerve structures...
October 18, 2016: HNO
Kathrin Günther, Ronja Foraita, Juliane Friemel, Frauke Günther, Jörn Bullerdiek, Rolf Nimzyk, Dominique Nadine Markowski, Thomas Behrens, Wolfgang Ahrens
BACKGROUND: The transcription factor high-mobility AT-hook 2 (HMGA2) is involved in stem cell renewal and is expressed in many tumor tissues. Head and neck squamous cell carcinomas (HNSCC) comprise tumors of the upper aerodigestive tract and are characterized by high recurrence rates that represent a challenge to patient management. The study addresses the potential of HMGA2 as a molecular biomarker for HNSCC patient survival. METHODS: Patients with HNSCC of the larynx, pharynx, tonsils, or oral cavity were recruited in a hospital-based case-control study (n=202)...
October 14, 2016: Cancer Epidemiology, Biomarkers & Prevention
Atsumori Hamahata, Takeshi Beppu, Takao Tokumaru, Takashi Yamaki, Hiroyuki Sakurai
Background For soft palate defects of more than two-thirds, we previously described the bent anterolateral thigh (ALT) method in which the pharyngeal isthmus was reconstructed as a tunnel structure. In this study, we compared the new "tunnel structure" reconstruction in our bent ALT flap method and the traditional "port structure" reconstruction. Methods From April 2010 to March 2015, 25 patients in Saitama Cancer Center (Saitama, Japan) underwent oropharyngeal tumor resection including soft palate resection...
October 3, 2016: Journal of Reconstructive Microsurgery
Stuart E Samuels, Avraham Eisbruch, Karen Vineberg, Jae Lee, Choonik Lee, Martha M Matuszak, Randall K Ten Haken, Kristy K Brock
PURPOSE: Strategies to reduce the toxicities of head and neck radiation (ie, dysphagia [difficulty swallowing] and xerostomia [dry mouth]) are currently underway. However, the predicted benefit of dose and planning target volume (PTV) reduction strategies is unknown. The purpose of the present study was to compare the normal tissue complication probabilities (NTCP) for swallowing and salivary structures in standard plans (70 Gy [P70]), dose-reduced plans (60 Gy [P60]), and plans eliminating the PTV margin...
November 1, 2016: International Journal of Radiation Oncology, Biology, Physics
W Chen, F L Xu, Y Chen, Y Zhang, K M Wu, Y Cheng, J F Ji, H L Zheng
Objective: To summarize clinical experience on application of transoral robotic surgery (TORS) in pharyngeal tumour resection. Methods: Six patients underwent TORS with da Vinci(®) surgical system in our department from November 2013 to July 2015 and their clinical data were analyzed retrospectively. Results: TORS was accomplished successfully in all 6 patients. The surgical field-exposed time ranged from 30 to 40 minutes with an average of 35 minutes. The operative time ranged from 30 to 130 minutes with an average of 72 minutes...
September 7, 2016: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
P Graff, V Woisard, S Racadot, J Thariat, Y Pointreau
Radio-induced pharyngolaryngeal chronic disorders may challenge the quality of life of head and neck cancer long survivors. Many anatomic structures have been identified as potentially impaired by irradiation and responsible for laryngeal edema, dysphonia and dysphagia. Some dose constraints might be plausible such as keeping the mean dose to the pharyngeal constrictor muscles under 50 to 55Gy, the mean dose to the supra-glottic larynx under 40 to 45Gy and, if feasible, the mean dose to the glottic larynx under 20Gy...
October 2016: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
Mark J Amsbaugh, Mehran Yusuf, Elizabeth Cash, Craig Silverman, Elizabeth Wilson, Jeffrey Bumpous, Kevin Potts, Cesar Perez, Robert Bert, Rebecca Redman, Neal Dunlap
PURPOSE/OBJECTIVE(S): To investigate the factors contributing to the clinical presentation of oropharyngeal squamous cell carcinoma (OPSCC) in the era of risk stratification using human papilloma virus (HPV) and smoking status. METHODS AND MATERIALS: All patients with OPSCC presenting to our institutional multidisciplinary clinic from January 2009 to June 2015 were reviewed from a prospective database. The patients were grouped as being at low risk, intermediate risk, and high risk in the manner described by Ang et al...
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Toshiyuki Yoshio, Tomohiro Tsuchida, Akiyoshi Ishiyama, Masami Omae, Toshiaki Hirasawa, Yorimasa Yamamoto, Junko Fujisaki, Yukiko Sato, Tohru Sasaki, Kazuyoshi Kawabata, Masahiro Igarashi
OBJECTIVES: Owing to increased awareness and the use of narrow band imaging, there are more opportunities to treat superficial pharyngeal cancer (SPC). This study aimed to describe the short- and long-term outcomes of ER (endoscopic resection) for SPC. METHODS: This study included 166 consecutive SPCs in 113 patients treated during 2006-2013 at one referral cancer center. In the first period, we treated patients using endoscopic mucosal resection (EMR), in the second period using conventional ESD (cESD) and in the recent period using double-scope ESD (dsESD), which involves a second thin endoscope for assistance to produce traction...
August 15, 2016: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
Rebecca Powell, Ekaterina Bubenshchikova, Yayoi Fukuyo, Chaonan Hsu, Olga Lakiza, Hiroki Nomura, Erin Renfrew, Deborah Garrity, Tomoko Obara
Wilm's tumor 1 interacting protein (Wtip) was identified as an interacting partner of Wilm's tumor protein (WT1) in a yeast two-hybrid screen. WT1 is expressed in the proepicardial organ (PE) of the heart, and mouse and zebrafish wt1 knockout models appear to lack the PE. Wtip's role in the heart remains unexplored. In the present study, we demonstrate that wtip expression is identical in wt1a‑, tcf21‑, and tbx18‑positive PE cells, and that Wtip protein localizes to the basal body of PE cells. We present the first genetic evidence that Wtip signaling in conjunction with WT1 is essential for PE specification in the zebrafish heart...
September 2016: Molecular Medicine Reports
A Tzankov
The mediastinum is a complex body region of limited space but containing numerous organs of different embryonic origins. A variety of lesions that are difficult to distinguish from each other can occur here. Non-neoplastic lesions of the mediastinum represent important differential diagnostic pitfalls to mediastinal tumors, clinically, radiologically and histopathologically. It is important to bear these lesions in mind and to adequately verify or exclude them before starting further differential diagnostic considerations on mediastinal neoplasms...
September 2016: Der Pathologe
Qi Su, Jiao He, Ziye Wang, Le Lv, Yuan Suo, Jingjing Wang, Zongwei Zheng, Chuanchuan Huo, Jing Li
ETHNOPHARMACOLOGICAL RELEVANCE: Menispermum dauricum DC., commonly known as "Bei Dou Gen" (BDG) in China, has been used extensively in folk medicine to treat inflammatory diseases, especially intestinal inflammations such as enteritis and dysentery, and in pharyngitis, tonsillitis, rheumatism and bronchitis. Although previous studies showed that BDG has anti-inflammatory activities, its effects on ulcerative colitis (UC) have not yet been explored. AIM OF THE STUDY: To investigate the intestinal anti-inflammatory effect of the rhizome extracts of Menispermum dauricum DC...
July 16, 2016: Journal of Ethnopharmacology
Y L Zhou, X D Wei, R H Mi, H Ai, L N Zhang, Y Y Liu, Y F Li, Y P Song
OBJECTIVE: To improve the clinical understanding of fungal esophagitis in patients with hematologic malignancies. METHOD: The clinical data of a cohort of 279 patients with hematologic malignancies who underwent gastroscopy between 2012 and 2015 in the Endoscopy Center of Henan Tumor Hospital were retrospectively analyzed. To investigate the clinical characteristics and prognosis of fungal esophagitis in patients with heratologic malignancies. RESULTS: 13 of the 279 patients were diagnosed as fungal esophagitis (4...
June 14, 2016: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
Qiang Zhang, Guowei Lu, Dajian Li
Neurogenic tumors located in the posterior mediastinum, generally require surgery which be confronted with greater risk,therefore, to design the best surgical approach and surgical methods is essential. A 67-year-old female patient had pharyngeal foreign body sensation and dysphagia. Thyroid ultrasound showed the right thyroid had a little nodule, and the left thyroid had a hypoechoic lumps. Neck enhanced CT showd mediastinal mass, esophageal tumor origin or stromal tumor? We used the jugular approach to resect the tumor which eventually diagnosed as schwannoma...
February 2016: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Chengyuan Wang, Summit Kundaria, Juan Fernandez-Miranda, Umamaheswar Duvvuri
OBJECTIVES/HYPOTHESIS: To illustrate detailed anatomy of the extracranial portion of the glossopharyngeal nerve in the parapharyngeal space as encountered during transoral surgery. STUDY DESIGN: Prospective cadaveric dissection. All dissections were performed transorally and confirmed with transcervical dissection. METHODS: Eight color-injected cadaveric heads (16 sides) were dissected to demonstrate the course and anatomy of the glossopharyngeal nerve...
September 2016: Laryngoscope
Shang-Wen Chen, Ying-Chun Lin, Rui-Yun Chen, Te-Chun Hsieh, Kuo-Yang Yen, Ji-An Liang, Shih-Neng Yang, Yao-Ching Wang, Ya-Huey Chen, Nan-Haw Chow, Chia-Hung Kao
BACKGROUND: This study examined genomic factors associated with a reduction in (18)fluoro-2-deoxy-D-glucose (FDG) uptake during positron emission tomography-computed tomography (PET-CT) for definitive chemoradiotherapy (CRT) in patients with pharyngeal cancer. METHODS: The pretreatment and interim PET-CT images of 25 patients with advanced pharyngeal cancers receiving definitive CRT were prospectively evaluated. The maximum standardized uptake value (SUVmax) of the interim PET-CT and the reduction ratio of the SUVmax (SRR) between the two images were measured...
June 16, 2016: European Journal of Nuclear Medicine and Molecular Imaging
Kamal Kishor Lakhera, Ashok M Shenoy, P Chavan, K Siddappa
To analyse pharyngocutaneous fistula, post Pectoralis major myocutaneous patch pharnygoplasty, and its association with various tumor, patient and treatment related factors. It is a retrospective study that included 48 patients who underwent laryngectomy and PMMC patch pharyngeal reconstruction from year 2009 to 2013. We studied the previously reported factors that could influence fistula formation such as age, gender, previous radiotherapy, previous tracheostomy, location of tumor, extent of tumor, tumor volume, tumor stage and surgical margins...
September 2015: Indian Journal of Surgical Oncology
Y M Zhu, H Zhang, S Ni, J Wang, D Z Li, S Y Liu
OBJECTIVE: To investigate the survival status of patients with pharyngeal, laryngeal or cervical esophageal cancers, who received free jejunal flap (FJF) to repair the defects following tumor resection, and to analyze the effect of multi-disciplinary treatment on their survival. METHODS: Fifty-eight patients with pharyngeal, laryngeal or cervical esophageal cancer underwent free jejunal flap (FJF) reconstruction after cancer resection between 2010 and 2013. All their clinical records were reviewed and analyzed...
May 23, 2016: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
Pei Zhang, Haiyu Hong, Xiaojin Sun, Hao Jiang, Shiyin Ma, Surong Zhao, Mengxiao Zhang, Zhiwei Wang, Chenchen Jiang, Hao Liu
Epithelial-mesenchymal transition (EMT) is an initiating event in tumor cell invasion and metastasis that contributes to therapeutic resistance to compounds including cisplatin. MicroRNAs (miRNAs) have been associated with EMT as well as resistance to standard therapies. However, the underlying mechanisms by which miRNAs control the development of resistance to cisplatin (DDP), and the accompanying EMT-like properties are required to elucidate. Here we show that microRNA-10b (miR-10b) is up-regulated in HNE1/DDP cells, and inhibition of miR-10b expression reversed the EMT phenotype...
2016: American Journal of Cancer Research
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