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https://www.readbyqxmd.com/read/27931212/pdgf-aa-mediates-mesenchymal-stromal-cell-chemotaxis-to-the-head-and-neck-squamous-cell-carcinoma-tumor-microenvironment
#1
Tammara L Watts, Ruwen Cui, Peter Szaniszlo, Vicente A Resto, Don W Powell, Irina V Pinchuk
BACKGROUND: The robust desmoplasia associated with head and neck squamous cell carcinoma (HNSCC) suggests that the tumor microenvironment may be an important component in the pathophysiology of this cancer. Moreover, the high recurrence rate and poor clinical response to chemotherapy and radiation treatment further underscores that the non-cancerous cells of the microenvironment, such as mesenchymal stromal cells (MSCs), cancer associated fibroblasts (CAFs), and pericytes, may be important in the pathophysiology of HNSCC...
December 8, 2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27930761/transoral-robotic-surgery-assisted-endoscopy-with-primary-site-detection-and-treatment-in-occult-mucosal-primaries
#2
Kyle M Hatten, Bert W O'Malley, Andres M Bur, Mihir R Patel, Christopher H Rassekh, Jason G Newman, Steven B Cannady, Ara A Chalian, Benjamin L Hodnett, Alexander Lin, John N Lukens, Roger B Cohen, Joshua M Bauml, Kathleen T Montone, Virginia A Livolsi, Gregory S Weinstein
Importance: Management of cervical lymph node metastasis without a known primary tumor is a diagnostic and treatment challenge for head and neck oncologists. Identification of the occult mucosal primary tumor minimizes the morbidity of treatment. Objective: To analyze the role of transoral robotic surgery (TORS) in facilitating the identification of a primary tumor site for patients presenting with squamous cell carcinoma of unknown primary (CUP). In addition, we assessed treatment deintensification by determining the number of patients who did not undergo definitive radiation therapy and chemotherapy...
December 8, 2016: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/27901506/squamous-cell-carcinoma-in-a-wild-european-bullhead-cottus-gobio
#3
F Quaglio, V Zappulli, L Poppi, P Capovilla, F Capparucci, F Marino
A pharyngeal tumor was found in a wild European bullhead. The tumor mass appeared underneath the operculum and was bilobed. The major neoplastic component showed diffuse epithelial squamous differentiation. Crossmonn's trichrome allowed identification of connective tissues whereas no neoplastic cells were stained. Periodic acid-Schiff was negative within the mass, and Giemsa did not show any further diagnostic significance. Immunohistochemistry showed diffuse positive cytoplasmic staining of the neoplastic population with an anti-human pancytokeratin antibody...
November 22, 2016: Diseases of Aquatic Organisms
https://www.readbyqxmd.com/read/27805282/toll-like-receptor-3-stimulation-triggers-metabolic-reprogramming-in-pharyngeal-cancer-cell-line-through-myc-mapk-and-hif
#4
Tanja Matijevic Glavan, Ana Cipak Gasparovic, Benjamin Vérillaud, Pierre Busson, Jasminka Pavelic
Toll-like receptor 3 (TLR3) has a dual role in cancer; its activation can trigger apoptosis as well as stimulate cancer cell survival, proliferation, and progression. We have shown here that TLR3 activation can induce metabolic reprogramming in a pharyngeal cancer cell line, leading to increased aerobic glycolysis, cell migration, elevated levels of reactive oxidative species (ROS), and decreased anti-oxidative response. Key proteins in these signaling pathways are heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1), pyruvate kinase M2 (PKM2), and CD44 variants, which were over-expressed after TLR3 stimulation...
November 2, 2016: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/27801551/sample-preparation-method-considerations-for-integrated-transcriptomic-and-proteomic-analysis-of-tumors
#5
Anupama Rajan Bhat, Manoj Kumar Gupta, Priya Krithivasan, Kunal Dhas, Jayalakshmi Nair, Ram Bhupal Reddy, H V Sudheendra, Sandip Chavan, Harsha Vardhan, Sujatha Darsi, Lavanya Balakrishnan, Shanmukh Katragadda, Vikram Kekatpure, Amritha Suresh, Pramila Tata, Binay Panda, Moni A Kuriakose, Ravi Sirdeshmukh
Sample processing protocols that enable compatible recovery of differentially expressed (DE) transcripts and proteins are necessary for integration of the multiomics data applied in the analysis of tumors. In this pilot study, we compared two different isolation methods for extracting RNA and protein from laryngo-pharyngeal tumor tissues and the corresponding adjacent normal sections. In Method 1, RNA and protein were isolated from a single tissue section sequentially and in Method 2, the extraction was carried out using two different sections and two independent and parallel protocols for RNA and protein...
November 1, 2016: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/27793330/otorhinolaryngology-manifestations-secondary-to-oral-sex
#6
Claudia Fernández-López, Carmelo Morales-Angulo
INTRODUCTION: Over the last few years, oral and pharyngeal signs and symptoms due to oral sex have increased significantly. However, no review articles related to this subject have been found in the medical literature. The objective of our study was to identify otorhinolaryngological manifestations associated with orogenital/oroanal contact, both in adults and children, in the context of consensual sex or sexual abuse. METHODS: We performed a review of the medical literature on otorhinolaryngological pathology associated with oral sex published in the last 20 years in the PubMed database...
October 25, 2016: Acta Otorrinolaringológica Española
https://www.readbyqxmd.com/read/27764170/clinical-implications-of-fadd-gene-amplification-and-protein-overexpression-in-taiwanese-oral-cavity-squamous-cell-carcinomas
#7
Huei-Tzu Chien, Sou-De Cheng, Wen-Yu Chuang, Chun-Ta Liao, Hung-Ming Wang, Shiang-Fu Huang
Amplification of 11q13.3 is a frequent event in human cancers, including head and neck squamous cell carcinoma. This chromosome region contains several genes that are potentially cancer drivers, including FADD (Fas associated via death domain), an apoptotic effector that was previously identified as a novel oncogene in laryngeal/pharyngeal cancer. This study was designed to explore the role of FADD in oral squamous cell carcinomas (OSCCs) samples from Taiwanese patients, by assessing copy number variations (CNVs) and protein expression and the clinical implications of these factors in 339 male OSCCs...
2016: PloS One
https://www.readbyqxmd.com/read/27762071/immunohistochemical-studies-and-fluorodeoxyglucose-uptake-on-positron-emission-tomography-in-pharyngeal-cancer-for-predicting-radiotherapy-based-treatment-outcomes
#8
Y-C Lin, R-Y Chen, S-W Chen, T-C Hsieh, K-Y Yen, J-A Liang, S-N Yang, Y-C Wang, Y-H Chen, N-H Chow, C-H Kao
OBJECTIVES: This study correlated immunohistochemical studies with fluorodeoxyglucose (FDG) uptake on positron emission tomography-computed tomography (PET-CT) and identified prognostic factors for radiotherapy (RT)-based treatment outcomes in patients with squamous cell carcinoma of the oropharynx and hypopharynx. METHODS: Genomic data from pre-treatment biopsy specimens (Glut1, CAIX, VEGF, HIF-1α, EGFR, Ki-67, Bcl-2, CLAUDIN-4, YAP-1, c-Met and p16) of 76 patients were analysed using tissue microarrays...
October 20, 2016: Clinical Otolaryngology
https://www.readbyqxmd.com/read/27757479/-diagnosis-and-treatment-of-parapharyngeal-space-tumors
#9
F Bootz, S Greschus, T van Bremen
The parapharyngeal space extends from the nasopharynx to the oropharynx. It is bordered medially by the pharyngeal wall and the constrictor pharyngis muscles, and laterally by the mandible. One distinguishes between a pre- and a poststyloid space. Tumors of the parapharyngeal space are rare and represent less than 1 % of all head and neck neoplasms. Benign (70-80 %) as well as malignant (20-30 %) tumors arise from different structures of the parapharyngeal space, mainly from salivary glands and nerve structures...
October 18, 2016: HNO
https://www.readbyqxmd.com/read/27742669/the-stem-cell-factor-hmga2-is-expressed-in-non-hpv-associated-head-and-neck-squamous-cell-carcinoma-and-predicts-patient-survival-of-distinct-subsites
#10
Kathrin Günther, Ronja Foraita, Juliane Friemel, Frauke Günther, Jörn Bullerdiek, Rolf Nimzyk, Dominique Nadine Markowski, Thomas Behrens, Wolfgang Ahrens
BACKGROUND: The transcription factor high-mobility AT-hook 2 (HMGA2) is involved in stem cell renewal and is expressed in many tumor tissues. Head and neck squamous cell carcinomas (HNSCC) comprise tumors of the upper aerodigestive tract and are characterized by high recurrence rates that represent a challenge to patient management. The study addresses the potential of HMGA2 as a molecular biomarker for HNSCC patient survival. METHODS: Patients with HNSCC of the larynx, pharynx, tonsils, or oral cavity were recruited in a hospital-based case-control study (n=202)...
October 14, 2016: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/27699727/a-comparison-of-large-soft-palate-defect-reconstruction-using-the-new-tunnel-structure-and-traditional-port-structure-methods
#11
Atsumori Hamahata, Takeshi Beppu, Takao Tokumaru, Takashi Yamaki, Hiroyuki Sakurai
Background For soft palate defects of more than two-thirds, we previously described the bent anterolateral thigh (ALT) method in which the pharyngeal isthmus was reconstructed as a tunnel structure. In this study, we compared the new "tunnel structure" reconstruction in our bent ALT flap method and the traditional "port structure" reconstruction. Methods From April 2010 to March 2015, 25 patients in Saitama Cancer Center (Saitama, Japan) underwent oropharyngeal tumor resection including soft palate resection...
October 3, 2016: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/27681761/methods-for-reducing-normal-tissue-complication-probabilities-in-oropharyngeal-cancer-dose-reduction-or-planning-target-volume-elimination
#12
Stuart E Samuels, Avraham Eisbruch, Karen Vineberg, Jae Lee, Choonik Lee, Martha M Matuszak, Randall K Ten Haken, Kristy K Brock
PURPOSE: Strategies to reduce the toxicities of head and neck radiation (ie, dysphagia [difficulty swallowing] and xerostomia [dry mouth]) are currently underway. However, the predicted benefit of dose and planning target volume (PTV) reduction strategies is unknown. The purpose of the present study was to compare the normal tissue complication probabilities (NTCP) for swallowing and salivary structures in standard plans (70 Gy [P70]), dose-reduced plans (60 Gy [P60]), and plans eliminating the PTV margin...
November 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27666710/-application-of-transoral-robotic-surgery-in-pharyngolaryngeal-tumour-resection
#13
W Chen, F L Xu, Y Chen, Y Zhang, K M Wu, Y Cheng, J F Ji, H L Zheng
Objective: To summarize clinical experience on application of transoral robotic surgery (TORS) in pharyngeal tumour resection. Methods: Six patients underwent TORS with da Vinci(®) surgical system in our department from November 2013 to July 2015 and their clinical data were analyzed retrospectively. Results: TORS was accomplished successfully in all 6 patients. The surgical field-exposed time ranged from 30 to 40 minutes with an average of 35 minutes. The operative time ranged from 30 to 130 minutes with an average of 72 minutes...
September 7, 2016: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/27599684/-head-and-neck-intensity-modulated-radiation-therapy-normal-tissues-dose-constraints-pharyngeal-constrictor-muscles-and-larynx
#14
P Graff, V Woisard, S Racadot, J Thariat, Y Pointreau
Radio-induced pharyngolaryngeal chronic disorders may challenge the quality of life of head and neck cancer long survivors. Many anatomic structures have been identified as potentially impaired by irradiation and responsible for laryngeal edema, dysphonia and dysphagia. Some dose constraints might be plausible such as keeping the mean dose to the pharyngeal constrictor muscles under 50 to 55Gy, the mean dose to the supra-glottic larynx under 40 to 45Gy and, if feasible, the mean dose to the glottic larynx under 20Gy...
October 2016: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/27598805/distribution-of-cervical-lymph-node-metastases-from-squamous-cell-carcinoma-of-the-oropharynx-in-the-era-of-risk-stratification-using-human-papillomavirus-and-smoking-status
#15
Mark J Amsbaugh, Mehran Yusuf, Elizabeth Cash, Craig Silverman, Elizabeth Wilson, Jeffrey Bumpous, Kevin Potts, Cesar Perez, Robert Bert, Rebecca Redman, Neal Dunlap
PURPOSE/OBJECTIVE(S): To investigate the factors contributing to the clinical presentation of oropharyngeal squamous cell carcinoma (OPSCC) in the era of risk stratification using human papilloma virus (HPV) and smoking status. METHODS AND MATERIALS: All patients with OPSCC presenting to our institutional multidisciplinary clinic from January 2009 to June 2015 were reviewed from a prospective database. The patients were grouped as being at low risk, intermediate risk, and high risk in the manner described by Ang et al...
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27525634/efficacy-of-double-scope-endoscopic-submucosal-dissection-and-long-term-outcomes-of-endoscopic-resection-for-superficial-pharyngeal-carcinomas
#16
Toshiyuki Yoshio, Tomohiro Tsuchida, Akiyoshi Ishiyama, Masami Omae, Toshiaki Hirasawa, Yorimasa Yamamoto, Junko Fujisaki, Yukiko Sato, Tohru Sasaki, Kazuyoshi Kawabata, Masahiro Igarashi
OBJECTIVES: Owing to increased awareness and the use of narrow band imaging, there are more opportunities to treat superficial pharyngeal cancer (SPC). This study aimed to describe the short- and long-term outcomes of ER (endoscopic resection) for SPC. METHODS: This study included 166 consecutive SPCs in 113 patients treated during 2006-2013 at one referral cancer center. In the first period, we treated patients using endoscopic mucosal resection (EMR), in the second period using conventional ESD (cESD) and in the recent period using double-scope ESD (dsESD), which involves a second thin endoscope for assistance to produce traction...
August 15, 2016: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/27484451/wtip-is-required-for-proepicardial-organ-specification-and-cardiac-left-right-asymmetry-in-zebrafish
#17
Rebecca Powell, Ekaterina Bubenshchikova, Yayoi Fukuyo, Chaonan Hsu, Olga Lakiza, Hiroki Nomura, Erin Renfrew, Deborah Garrity, Tomoko Obara
Wilm's tumor 1 interacting protein (Wtip) was identified as an interacting partner of Wilm's tumor protein (WT1) in a yeast two-hybrid screen. WT1 is expressed in the proepicardial organ (PE) of the heart, and mouse and zebrafish wt1 knockout models appear to lack the PE. Wtip's role in the heart remains unexplored. In the present study, we demonstrate that wtip expression is identical in wt1a‑, tcf21‑, and tbx18‑positive PE cells, and that Wtip protein localizes to the basal body of PE cells. We present the first genetic evidence that Wtip signaling in conjunction with WT1 is essential for PE specification in the zebrafish heart...
September 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27465275/-non-neoplastic-lesions-of-the-mediastinum
#18
A Tzankov
The mediastinum is a complex body region of limited space but containing numerous organs of different embryonic origins. A variety of lesions that are difficult to distinguish from each other can occur here. Non-neoplastic lesions of the mediastinum represent important differential diagnostic pitfalls to mediastinal tumors, clinically, radiologically and histopathologically. It is important to bear these lesions in mind and to adequately verify or exclude them before starting further differential diagnostic considerations on mediastinal neoplasms...
September 2016: Der Pathologe
https://www.readbyqxmd.com/read/27435376/intestinal-anti-inflammatory-effect-of-the-rhizome-extracts-of-menispermum-dauricum-dc-on-trinitrobenzene-sulfonic-acid-induced-ulcerative-colitis-in-mice
#19
Qi Su, Jiao He, Ziye Wang, Le Lv, Yuan Suo, Jingjing Wang, Zongwei Zheng, Chuanchuan Huo, Jing Li
ETHNOPHARMACOLOGICAL RELEVANCE: Menispermum dauricum DC., commonly known as "Bei Dou Gen" (BDG) in China, has been used extensively in folk medicine to treat inflammatory diseases, especially intestinal inflammations such as enteritis and dysentery, and in pharyngitis, tonsillitis, rheumatism and bronchitis. Although previous studies showed that BDG has anti-inflammatory activities, its effects on ulcerative colitis (UC) have not yet been explored. AIM OF THE STUDY: To investigate the intestinal anti-inflammatory effect of the rhizome extracts of Menispermum dauricum DC...
July 16, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27431077/-a-clinical-study-of-fungal-esophagitis-in-13-patients-with-hematologic-malignancies
#20
Y L Zhou, X D Wei, R H Mi, H Ai, L N Zhang, Y Y Liu, Y F Li, Y P Song
OBJECTIVE: To improve the clinical understanding of fungal esophagitis in patients with hematologic malignancies. METHOD: The clinical data of a cohort of 279 patients with hematologic malignancies who underwent gastroscopy between 2012 and 2015 in the Endoscopy Center of Henan Tumor Hospital were retrospectively analyzed. To investigate the clinical characteristics and prognosis of fungal esophagitis in patients with heratologic malignancies. RESULTS: 13 of the 279 patients were diagnosed as fungal esophagitis (4...
June 14, 2016: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
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