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pharyngeal tumor

W H Hou, P Wei, J L Xie, Y Y Zheng, Y L Zhang, X G Zhou
Objective: To investigate clinicopathological features and prognosis of tonsillar mantle cell lymphoma(TMCL). Methods: Clinical data of 25 patients with TMCL at Beijing Friendship Hospital, Capital Medical University from 2002 to 2016 were included. All the cases were reviewed microscopically. Various immunohistochemical stains were performed using the MaxVision two-step method. IgH/CCND1 gene fusion was detected by fluorescent in situ hybridization(FISH). Additionally, randomly selected 40 cases of non-tonsil MCL of the same period were compared...
March 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
Liang Li, Fengjuan Zhou, Fanzhong Lin, Cuihong Han
Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma (TL-LGNPPA) is an extremely rare neoplasm. It morphologically resembles papillary thyroid carcinoma and is immunochemically positive for thyroid transcription factor 1. Herein, we reported a case of TL-LGNPPA in a female patient of 35 years old. She felt pharyngeal foreign body sensation of unknown cause and subsequently developed dyspnea after activities. Nasopharyngeal plain computerized tomography showed no abnormalities, but laryngoscopy showed a peanut-sized smooth neoplasm with a pedicel at the posterior edge of the nasal septum...
February 28, 2018: Applied Immunohistochemistry & Molecular Morphology: AIMM
Shaghik Barani, Bijan Khademi, Elham Ashouri, Abbas Ghaderi
BACKGROUND: Activatingandinhibitory KIRreceptors (aKIR, iKIR) control the development and function of NK cells whose function alterations adjust the tumor microenvironment immunity. This research was conducted to determine the KIRs gene impact on genetic predisposition to Head and Neck Squamous Cell Carcinoma (HNSCC) in Iranians. METHODS: KIR genotyping usingsequence-specific primers-polymerase chain reaction (SSP-PCR) method was performed to identify the presence of all 16 KIRgenes in 285 HNSCC patients, including laryngeal, oral cavity and pharyngeal SCC and 273 controls (CNs)...
February 2, 2018: Human Immunology
Saloni P Sheth, Paul Ilkanich, Blaise Congeni
Fusobacterium infections and Lemierre Syndrome are traditionally associated with pharyngitis. We report three cases of Fusobacterium sinusitis that resulted in Pott Puffy Tumor. One of these cases also had Lemierre Syndrome. We encourage expansion of the clinical spectrum of Lemierre Syndrome to include complicated Fusobacterium sinusitis.
January 31, 2018: Pediatric Infectious Disease Journal
Stefania Gallo, Francesco Bandi, Marco-Paolo Maffioli, Marco Giudice, Paolo Castelnuovo, Enrico Fazio, Apostolos Karligkiotis
Introduction: Retropharyngeal space schwannomas are rare entities. About 20-45% of schwannomas occur in the head and neck region; however, they represent less than 1% of all head and neck tumors. Case Report: We present the case of a 36-year-old woman complaining of dysphagia caused by a large schwannoma arising in the posterior pharyngeal wall with remarkable reduction of the oropharyngeal space. The tumor was resected through a combined transoral and cervicotomic transmandibular approach due to its dimension...
November 2017: Iranian Journal of Otorhinolaryngology
L Jansen, N Buttmann-Schweiger, S Listl, M Ressing, B Holleczek, A Katalinic, S Luttmann, K Kraywinkel, H Brenner
INTRODUCTION: The epidemiology of squamous cell oral cavity and pharyngeal cancers (OCPC) has changed rapidly during the last years, possibly due to an increase of human papilloma virus (HPV) positive tumors and successes in tobacco prevention. Here, we compare incidence and survival of OCPC by HPV-relation of the site in Germany and the United States (US). MATERIALS AND METHODS: Age-standardized and age-specific incidence and 5-year relative survival was estimated using data from population-based cancer registries in Germany and the US Surveillance Epidemiology and End Results (SEER) 13 database...
January 2018: Oral Oncology
Gianluigi Mazzoccoli, Stefano Castellana, Massimo Carella, Orazio Palumbo, Cristiana Tiberio, Caterina Fusilli, Daniele Capocefalo, Tommaso Biagini, Tommaso Mazza, Lorenzo Lo Muzio
Oral squamous cell carcinoma (OSCC) is the most common oral and pharyngeal cancer, and is responsible of approximately 3% of cancers in men and 2% in women in the Western World, with increasing incidence rates in developing countries. Early detection by screening is necessary to prevent fatal disease because early, curable lesions are rarely symptomatic. The overall 5-yr survival rate is approximately 50% when surgery, radiation, or both are employed as treatment options, but lymph node involvement greatly influences this estimate, by decreasing the survival rate by about 50%...
December 1, 2017: Oncotarget
Sang-Yeon Kim, Young-Soo Rho, Eun-Chang Choi, Min-Sik Kim, Joo-Hyun Woo, Dong Hoon Lee, Eun Jae Chung, Min Woo Park, Da-Hee Kim, Young-Hoon Joo
BACKGROUND: The purpose of this study was to determine prognostic factors influencing outcomes of surgical treatment in patients with T4a hypopharyngeal cancer. METHODS: The present study enrolled 93 patients diagnosed with T4a hypopharyngeal cancer who underwent primary surgery between January 2005 and December 2015 at six medical centers in Korea. Primary tumor sites included pyriform sinus in 71 patients, posterior pharyngeal wall in 14 patients, and postcricoid region in 8 patients...
December 29, 2017: BMC Cancer
Shigeyuki Murono, Hiroshi Yoshida, Tetsuro Kobayashi, Tomotaka Kawase, Daisuke Kikuchi, Toshihiko Suzuki, Yosuke Nakanishi, Kazuhira Endo, Satoru Kondo, Naohiro Wakisaka, Tomokazu Yoshizaki
BACKGROUND: Multifocal human papillomavirus (HPV) infection into the palatine and pharyngeal tonsils, which might be linked to a second primary tumor of HPV-positive oropharyngeal cancer (OPC), was investigated. PATIENTS AND METHODS: One hundred and five patients with various head and neck diseases including 14 patients with OPC were enrolled in this study. Swabs from the palatine and pharyngeal tonsils were collected in each individual, and auto-nested GP5+/GP6+ PCR for HPV DNA was performed...
November 29, 2017: Acta Oto-laryngologica
Jun Won Kim, Hyung Kwon Byeon, Hong-Shik Choi, Ik Jae Lee
We evaluated the efficacy of dose de-escalation to the normal larynx using conformal radiotherapy (CRT) for T1/T2 glottic cancer. For conventional RT (2DRT, n = 38), the laryngeal box received a median equivalent dose in 2 Gy fractions (EQD2) of 66 Gy. For CRT (n = 42; 3D-CRT, 20; intensity-modulated RT, 22), clinical target volume (CTV)1 (gross tumor with a 3-mm margin) and CTV2 (laryngeal box) received median EQD2s of 66.6 Gy and 52.2 Gy, respectively. With a 71-month median follow-up, five-year local control and overall survival rates for 2DRT vs...
November 16, 2017: Scientific Reports
Zhong-Xin Zhou, Shao-Feng Mou, Xiao-Qin Chen, Li-Li Gong, Wen-Sheng Ge
Recent studies have demonstrated that resveratrol can reduce blood sugar, improve insulin resistance, regulate abnormalities in lipid metabolism, and lower the secretion and expression of inflammatory factors. The present study investigated the anti‑inflammatory effects of resveratrol in animal models of acute pharyngitis, and its possible mechanisms. Commercial ELISA kits were used to measure tumor necrosis factor‑α, interleukin (IL)‑6, macrophage inflammatory protein‑2, cyclooxygenase‑2 levels and caspase‑3/9 activity...
January 2018: Molecular Medicine Reports
Xuejun Liu, Chuqin Zhang, Zhonghua Zhang, Zuping Zhang, Wei Ji, Shengda Cao, Xiaolan Cai, Dapeng Lei, Xinliang Pan
The E26 transformation-specific (ETS) family is one of the largest families of transcription factors. Upon activation by MAPK pathway, ETS participates in cell proliferation, differentiation, migration, apoptosis, and metastasis. However, the mechanism by which ETS is deregulated in cancer is unclear. In this study, the authors investigated the role of ETS factor, ETS2, in hypopharyngeal cancer pathogenesis in hypopharyngeal cancer tissues (N = 20) and corresponding non-neoplastic tissues (N = 20). The results showed that expression of ETS2 was increased in cancer tissues as compared with the expression in corresponding non-neoplastic tissues...
November 2017: Cancer Biotherapy & Radiopharmaceuticals
Rui-Yun Chen, Ying-Chun Lin, Shang-Wen Chen, Tze-Yi Lin, Te-Chun Hsieh, Kuo-Yang Yen, Ji-An Liang, Shih-Neng Yang, Yao-Ching Wang, Ya-Huey Chen, Shu-Fen Chiang, Chia-Hung Kao
BACKGROUND: This study determined the prognostic effects of immunohistochemical biomarkers and volumetric parameters predicting radiotherapy-based treatment in patients with p16-negative squamous cell carcinoma of the oropharynx or hypopharynx. RESULTS: VEGF immunoreactivity > 2 and GLUT1 overexpression were prognostic factors for lower cause-specific survival. Moreover, both factors were associated with lower disease-free survival. The predictors of lower primary relapse-free survival were VEGF immunoreactivity > 2 and CT-based gross tumor volume > 16 mL...
September 22, 2017: Oncotarget
Rumi Ueha, Takaharu Nito, Takao Goto, Taku Sato, Tetsuo Ushiku, Tatsuya Yamasoba
Human cytomegalovirus (CMV) is an infectious herpes virus present in approximately 50% of the world's population. Pharyngitis is an uncommon manifestation of CMV infection, and vocal cord immobility (VCI) following CMV pharyngitis is quite rare. An 83-year-old man with well-controlled diabetes mellitus and hypertension was admitted due to dyspnea, odynophagia, and dysphagia. Laryngeal fiberscopy revealed bilateral vocal cords almost fixed at the median position, with mucosal redness, swelling, and edema at the hypopharyngeal area...
October 17, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
Jeon Yeob Jang, Kyoung June Pak, Keun-Ik Yi, Yong Kan Ki, Won Taek Kim, Hyojeong Kim, Young Jin Choi, Seong Jang Kim, In Joo Kim, Soo-Geun Wang, Young Mi Seol
BACKGROUND/AIM: We aimed to explore the prognostic value of metabolic heterogeneity of (18)F-FDG uptake in chemoradiotherapy-treated pharyngeal cancer patients. PATIENTS AND METHODS: This study included 52 consecutive patients with pharyngeal cancer who underwent (18)F-FDG PET/CT before definitive chemoradiotherapy. The heterogeneity factor (HF) was defined as the derivative (dV/dT) of a volume-threshold function for primary tumors and metastatic lymph nodes. The relationships between clinical parameters and HFs of primary tumors (pHF) and metastatic lymph nodes (nHF) were analyzed...
October 2017: Anticancer Research
Takuma Matoba, Kei Ijichi, Takeshi Yanagi, Kayoko Kabaya, Daisuke Kawakita, Shintaro Beppu, Junichi Torii, Shingo Murakami
Background: Induction chemotherapy for patients with head and neck cancer is widely performed, and several advantages of induction chemotherapy have been reported. However, there is currently insufficient evidence to strongly recommend induction chemotherapy. In this study, we analyzed the outcomes for patients treated with induction chemotherapy and subsequent definitive treatments. Methods: Operable patients with untreated oropharyngeal, hypopharyngeal and laryngeal squamous cell carcinoma treated with induction chemotherapy were included in this retrospective study...
August 18, 2017: Japanese Journal of Clinical Oncology
Xingwen Wang, Eldan Eichbaum, Fengzeng Jian, Dean Chou
BACKGROUND: En bloc excision of cervical chordoma is a technically complex procedure, due to the involvement and closeness of the tumor to the spinal cord, cervical nerve roots, and vertebral arteries. Studies have previously shown that en bloc excision of chordomas with negative margins improves local control and prolongs disease-free survival compared with intralesional excision. True en bloc spondylectomy in the cervical spine is not feasible since bilateral vertebral artery sacrifice is not possible...
August 9, 2017: Operative Neurosurgery (Hagerstown, Md.)
Bing-Zhao Du, Xin-Yao Yang, Xiao Feng, Xu Yin, He-Xin-Ge Zhang, Feng Zhao, Zeng-Ping Gao, Peng-Fei Tu, Xing-Yun Chai
Ilex asprella is one of representative medicinal plants in South of the Five Ridges of China. The roots and rhizomes of I. asprella have the effects of clearing heat and detoxifying, stimulating salvia, and reducing thirst, which has been used to treat wind-heat cold, acute and chronic pharyngitis, and sore throat. Contemporary studies showed that I. asprella contains the major triterpenoids and glycosides, phenolic acids, and minor steroids. The extracts and compounds show activities of anti-inflammatory, antiviral, anti-tumor, and regulating lipid metabolism...
January 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Kim Wopken, Hendrik P Bijl, Johannes A Langendijk
BACKGROUND: Tube feeding dependence is a commonly observed debilitating side-effect of curative (chemo-) radiation in head and neck cancer patients that severely affects quality of life. Prevention of this side-effect can be obtained using advanced radiation techniques, such as IMRT. For radiotherapy treatment plan optimization, it has become increasingly important to develop prediction models that enable clinicians to predict the risk of tube feeding dependence for individual patients...
September 21, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Federico Attene, Ilia Patrizia Pisano, Carlo Pala, Antonio Marrosu, Corrado Bozzo, Fabrizio Scognamillo
INTRODUCTION: Carcinoma showing thymous-like elements (CASTLE) is a rare tumor with only a few cases described in the scientific literature. The aim of the present review is to analyze the data available on the therapeutic options employed in CASTLE tumors and to outline the best surgical management to adopt. MATERIALS AND METHODS: English-language articles published from 1985 through November 2016, and related to CASTLE cases were retrieved using the Pubmed database and specific key-words...
2017: Annali Italiani di Chirurgia
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