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https://www.readbyqxmd.com/read/29653204/epha3-maintains-radioresistance-in-head-and-neck-cancers-through-epithelial-mesenchymal-transition
#1
Song Hee Kim, Won Hyeok Lee, Seong Who Kim, Je Hyoung Uk, Jong Cheol Lee, Hyo Won Chang, Young Min Kim, Kyungbin Kim, Sang Yoon Kim, Myung Woul Han
Radiotherapy is a well-established therapeutic modality used in the treatment of many cancers. However, radioresistance remains a serious obstacle to successful treatment. Radioresistance can cause local recurrence and distant metastases in some patients after radiation treatment. Thus, many studies have attempted to identify effective radiosensitizers. Eph receptor functions contribute to tumor development, modulating cell-cell adhesion, invasion, neo-angiogenesis, tumor growth and metastasis. However, the role of EphA3 in radioresistance remains unclear...
April 10, 2018: Cellular Signalling
https://www.readbyqxmd.com/read/29626364/elevated-expression-of-keratin-17-in-oropharyngeal-squamous-cell-carcinoma-is-associated-with-decreased-survival
#2
Elliot Regenbogen, Michelle Mo, Jamie Romeiser, A Laurie W Shroyer, Luisa F Escobar-Hoyos, Stephanie Burke, Kenneth R Shroyer
BACKGROUND: Overexpression of keratin 17 (K17) is highly associated with poor prognosis in squamous cell carcinoma (SCC) of the cervix. This study was performed to (1) determine whether K17 may be a prognostic biomarker in head and neck squamous cell carcinoma (HNSCC) and (2) to establish if K17 expression is associated with human papillomavirus (HPV) status. METHODS: Immunohistochemical staining was performed for K17 of oral, oropharyngeal, and laryngeal SCCs, and normal oropharyngeal mucosa...
April 6, 2018: Head & Neck
https://www.readbyqxmd.com/read/29599595/non-hodgkin-s-lymphoma-of-the-mandible-in-hiv-patient-a-rare-case-report
#3
Mahesh Neerupakam, Jacob Prakash, Sridevi Koduri, Thejasri Vishnubhatla
Non-Hodgkin's lymphoma (NHL) is a lymphatic system tumor originating from either B or T lymphocytes and shows a high malignant potential. In HIV-seropositive patients, NHL of head and neck is mainly found in Waldeyer's ring, oral mucosa, salivary glands, paranasal sinuses, and laryngeal tissue. Primary NHL rarely affects the bone. When the lesion affects the bones of the jaws, it is rare in the mandible when compared to the maxilla. In the reported cases, only 0.6% are found in the mandible. NHL of the mandible can be difficult to diagnose, and so the prime aim of the present case report is to establish appropriate diagnosis of one of such kinds...
January 2018: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/29598944/three-dimensional-imaging-assessment-of-anatomic-invasion-and-volumetric-considerations-for-chemo-radiotherapy-based-laryngeal-preservation-in-t3-larynx-cancer
#4
Mona Kamal, Sweet Ping Ng, Salman A Eraj, Crosby D Rock, Brian Pham, Jay A Messer, Adam S Garden, William H Morrison, Jack Phan, Steven J Frank, Adel K El-Naggar, Jason M Johnson, Lawrence E Ginsberg, Renata Ferrarotto, Jan S Lewin, Katherine A Hutcheson, Carlos E Cardenas, Mark E Zafereo, Stephen Y Lai, Amy C Hessel, Randal S Weber, G Brandon Gunn, Clifton D Fuller, Abdallah S R Mohamed, David I Rosenthal
OBJECTIVES: To investigate the impact of 3-Diminsional (3D) tumor volume (TV) and extent of involvement of primary tumor on treatment outcomes in a large uniform cohort of T3 laryngeal carcinoma patients treated with nonsurgical laryngeal preservation strategies. MATERIALS AND METHODS: The pretreatment contrast-enhanced computed tomography images of 90 patients with T3 laryngeal carcinoma were reviewed. Primary gross tumor volume (GTVp) was delineated to calculate the 3D TV and define the extent of invasion...
April 2018: Oral Oncology
https://www.readbyqxmd.com/read/29573243/lncrna-nkila-nf-%C3%AE%C2%BAb-feedback-loop-modulates-laryngeal-cancer-cell-proliferation-invasion-and-radioresistance
#5
Tao Yang, Shisheng Li, Jiajia Liu, Danhui Yin, Xinming Yang, Qinglai Tang
Laryngeal cancer is one of the most common head and neck malignant tumors and is commonly resistant to X-ray-based radiotherapy. NF-κB interacting lncRNA (NKILA) has been reported to serve as a tumor suppressor in several cancers through combining with NF-κB: IκB complex thereby inhibiting NF-κB activation. Herein, we demonstrated a low NKILA expression in laryngeal cancer and its correlation with shorter overall survival in patients with laryngeal cancer. NKILA serves as a tumor suppressor in laryngeal cancer by suppressing laryngeal cancer cell viability and migration, whereas promoting cell apoptosis; NKILA knockdown reverses the cytotoxicity of X-ray radiation on laryngeal cancer cells through combining with NF-κB: IκB complex to inhibit IκB phosphorylation, inhibit p65 nuclear translocation, and finally inhibit NF-κB activation...
March 23, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29566279/recurrent-transcriptional-loss-of-the-pcdh17-tumor-suppressor-in-laryngeal-squamous-cell-carcinoma-is-partially-mediated-by-aberrant-promoter-dna-methylation
#6
Ewa Byzia, Natalia Soloch, Magdalena Bodnar, Marcin Szaumkessel, Katarzyna Kiwerska, Magdalena Kostrzewska-Poczekaj, Malgorzata Jarmuz-Szymczak, Lukasz Szylberg, Malgorzata Wierzbicka, Anna Bartochowska, Ewelina Kalinowicz, Reidar Grenman, Krzysztof Szyfter, Andrzej Marszalek, Maciej Giefing
Protocadherins are cell-cell adhesion molecules encoded by a large family of genes. Recent reports demonstrate recurrent silencing of protocadherin genes in tumors and provide strong arguments for their tumor supresor functionality. Loss of protocadherins may contribute to cancer development not only by altering cell-cell adhesion, that is a hallmark of cancer, but also by enhancing proliferation and epithelial mesenchymal transition of cells via deregulation of the WNT signaling pathway. In this study we have further corroborated our previous findings on the involvement of PCDH17 in laryngeal squamous cell carcinoma (LSCC)...
March 22, 2018: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/29563964/comparative-assessment-of-hpv-alcohol-and-tobacco-etiological-fractions-in-algerian-patients-with-laryngeal-squamous-cell-carcinoma
#7
Nora Kariche, Montserrat Torres Hortal, Samir Benyahia, Laia Alemany, Nabila Moulaï, Omar Clavero, Marleny Muñoz, Wahiba Ouahioune, Djamel Djennaoui, Chafia Touil-Boukoffa, Silvia de Sanjosé, Mehdi Bourouba
Background: Despite the increasing incidence of laryngeal squamous cell carcinoma (LSCC) in Algeria, scarce information is available on the importance of the preventable etiological factors which may drive the disease. Remarkably, a significant number of cases occur in nonsmoker and nondrinker patients; hence, suggesting that alternative risk factors, like Human papillomavirus (HPV), might be etiologically involved. To gain more insight on the risk factors associated with the disease in the country, we evaluated the etiological fraction of HPV in comparison to tobacco and alcohol intake in LSCC patients...
2018: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/29563911/seroprevalence-of-neutralizing-antibodies-against-human-adenovirus-type-5-and-chimpanzee-adenovirus-type-68-in-cancer-patients
#8
Hua Zhao, Can Xu, Xiaoli Luo, Feng Wei, Ning Wang, Huiying Shi, Xiubao Ren
Since the preclinical results about chimpanzee adenovirus serotype-68 (AdC68)-based vaccine showed an encouraging results, it reminded us that AdC68 may be a suitable cancer vaccine vector. Previous study indicated that the seroprevalence of neutralizing antibodies (NAbs) against adenovirus was different between cancer patients and healthy volunteers. Knowledge regarding the prevalence rates of AdC68 NAbs for cancer patients is lacking. Therefore, assessing the preexistence of NAbs against AdC68 in cancer patients could provide useful insights for developing future AdC68-based cancer vaccines...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29563811/creb-promotes-laryngeal-cancer-cell-migration-via-myct1-nat10-axis
#9
Zhao-Xiong Zhang, Wan-Ni Zhang, Yuan-Yuan Sun, Yun-Hui Li, Zhen-Ming Xu, Wei-Neng Fu
Purpose: CREB, MYCY1 and NAT10 are involved in cancer cell migration. However, the relationship between these three proteins and their role in laryngeal cancer cell migration remains unknown. Methods: Transient gene transfection was performed in laryngeal cancer cells. Bioinformatics analysis was used to predict the binding of CREB to MYCT1 promoter. Binding of CREB to the promoter of MYCT1 was monitored by luciferase reporter assay and chromatin immuno-precipitation method in vitro and in vivo, respectively...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29562960/mir-632-promotes-laryngeal-carcinoma-cell-proliferation-migration-and-invasion-through-negative-regulation-of-gsk3%C3%AE
#10
Zhong-Xin Zhou, Zu-Ping Zhang, Ze-Zhang Tao, Ting-Zhao Tan
Laryngeal cancer, one of the most common head and neck malignancies, is an aggressive neoplasm. Increasing evidence hasdemonstrated that microRNAs (miRNAs) exert important roles in oncogenesis and progression of diverse types of human cancers. MiR-632, a tumor-related miRNA, has been reported to be dysregulated and implicated in human malignancies; however, its biological role in laryngeal carcinoma remains to be elucidated. The present study aimed at exploring the role of miR-632 in laryngeal cancer and clarifying the potential molecular mechanisms involved...
March 21, 2018: Oncology Research
https://www.readbyqxmd.com/read/29559790/the-use-of-the-c-mac-videolaryngoscope-for-awake-intubation-in-patients-with-a-predicted-extremely-difficult-airway-case-series
#11
Tomasz Gaszyński
The C-MAC videolaryngoscope was evaluated for intubation in patients with predicted extremely difficult airway. The presented cases are patients with neoplasm tumors in larynx. In all cases, awake intubation using C-MAC videolaryngoscope was performed in patients breathing spontaneously, under local anaesthesia, with oxygen administered via nasal catheter. All intubations were successful and uneventful. The pre-surgery examination (CT scans and fiberscope laryngeal examination) was compared with view of larynx obtained during laryngoscopy...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29554402/quality-of-life-in-patients-with-larynx-cancer-in-latin-america-comparison-between-laryngectomy-and-organ-preservation-protocols
#12
Alvaro Sanabria, Daniel Sánchez, Andrés Chala, Andres Alvarez
The effect on quality of life (QOL) of laryngectomy and organ preservation protocols is important in decision making. The aim of this cross-sectional study was to evaluate QOL outcomes of patients with advanced laryngeal tumors who were treated with laryngectomy or organ preservation protocols in Latin America. A total of 35 patients from three oncology units were enrolled. Patients with stage III/IV laryngeal cancer who were treated using organ preservation protocols or laryngectomy were assessed with the University of Washington QOL Questionnaire...
March 2018: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/29549895/the-prevalence-of-lymph-node-metastasis-for-pathological-t1-esophageal-cancer-a-retrospective-study-of-143-cases
#13
Xiao-Feng Duan, Peng Tang, Xiao-Bin Shang, Hong-Jing Jiang, Zhen-Tao Yu
OBJECTIVE: To evaluate the prevalence, pattern and risk factors of lymph node metastasis (LNM) for pathological T1 (pT1) esophageal cancer (EC). METHODS: The clinical data of 143 cases of pT1 patients who underwent esophagectomy and lymph node dissection during January 2011 and July 2016 were reviewed, including 120 male patients and 23 female patients with a median age of 60 years. The pattern of LNM was analyzed and the risk factors related to LNM were assessed by logistic regression analysis...
March 2018: Surgical Oncology
https://www.readbyqxmd.com/read/29548015/granular-cell-tumor-report-of-13-cases-in-a-veterans-administration-hospital
#14
Alexander D Jobrack, Suman Goel, Alvin M Cotlar
Introduction: Granular cell tumors (GCTs) are of neuroectodermal origin and account for 0.5% of soft tissue tumors. They are most prevalent in African-Americans in the fourth to sixth decades, with a predilection for the head and neck regions. GCTs usually resemble more common lesions and hence are difficult to diagnose preoperatively. The tumor is readily identified on needle biopsy. Although usually benign with a malignancy rate of only 2-3%, the malignant form has a reported 3-yr mortality of 60%...
March 14, 2018: Military Medicine
https://www.readbyqxmd.com/read/29545847/expression-of-dna-dependent-protein-kinase-catalytic-subunit-in-laryngeal-squamous-cell-carcinoma-and-its-importance
#15
Jian-Song Sun, Xiu-Hai Yang
The aim of the present study was to explore the expression and distribution of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) in tumor tissues and adjacent normal mucosa tissues of patients with laryngeal squamous cell carcinoma (LSCC), and further analyze the association between the expression and the clinicopathological parameters of patients with LSCC. Clinical data of tumor tissues and corresponding adjacent normal mucosa tissues of pathologically diagnosed LSCC in 96 cases were collected in the present study...
April 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29541239/-prr4-a-novel-downregulated-gene-in-laryngeal-cancer
#16
Seda Ekizoglu, Turgut Ulutin, Jalal Guliyev, Nur Buyru
Head and neck squamous cell carcinomas (HNSCC) are a diverse group of tumor types, including neoplasia of the paranasal sinuses, oral cavity, trachea, pharynx and larynx. Laryngeal cancer is the most common type of HNSCC. The proline-rich 4 (PRR4) protein is synthesized in the acinar cells of human lacrimal glands. Previous studies have demonstrated that PRR4 may function as an antimicrobial protein protecting the ocular surface and the oral cavity. In order to determine differentially expressed genes (DEGs) in laryngeal tumors, a GeneFishing Assay was performed; 27 DEGs were identified...
April 2018: Oncology Letters
https://www.readbyqxmd.com/read/29538201/salivary-duct-carcinoma-of-the-supraglottis-with-a-distinct-presentation-a-case-report-and-literature-review
#17
Cheng-Chieh Hsu, Wing-Yin Li, Pen-Yuan Chu
RATIONALE: Salivary duct carcinoma (SDC) is a rare and aggressive subtype of salivary gland carcinoma that histologically resembles in situ and invasive ductal carcinoma of the breast. We present the first case of advanced SDC of the minor salivary gland arising from the supraglottis and review the literature on the clinicopathologic characteristics and prognosis of SDC. PATIENT CONCERNS: A 59-year-old male patient with progressive difficulty in swallowing and a muffled voice for 2 months...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29533345/the-value-of-whole-body-contrast-enhanced-18f-fdg-pet-ct-imaging-in-the-diagnosis-and-staging-of-patients-with-laryngeal-carcinoma
#18
Gamze Tatar, Tevfik F Cermik, Yesim Karagoz, Cihan Gundogan, Didem Karacetin, Elif Yildiz, Ozgur Yigit
PURPOSE: This study aimed to determine whether intravenous contrast-enhanced dual-phase fluorine-18--fluorodeoxyglucose (F-FDG) PET/CT scans provide additional diagnostic information compared with the MRI/CT in patients with laryngeal carcinoma during the initial staging. PATIENTS AND METHODS: Forty-five consecutive patients (44 men, one woman; mean age±SD, 67.0±9.0 years, range: 45-80 years) with carcinoma of the larynx who had MRI/CT and intravenous contrast-enhanced PET/CT were enrolled...
April 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29523110/cd31-and-vegf-are-prognostic-biomarkers-in-early-stage-but-not-in-late-stage-laryngeal-squamous-cell-carcinoma
#19
Anke Schlüter, Patrick Weller, Oliver Kanaan, Ivonne Nel, Lukas Heusgen, Benedikt Höing, Pia Haßkamp, Sebastian Zander, Magis Mandapathil, Nina Dominas, Judith Arnolds, Boris A Stuck, Stephan Lang, Agnes Bankfalvi, Sven Brandau
BACKGROUND: Patients suffering from squamous cell carcinoma of the larynx (LSCC) with lymphatic metastasis have a relatively poor prognosis and often require radical therapeutic management. The mechanisms which drive metastasis to the lymph nodes are largely unknown but may be promoted by a pro-angiogenic tumor microenvironment. In this study, we examined whether the number of microvessels and the expression level of vascular endothelial growth factor (VEGF) in the primary tumor are correlated with the degree of lymph node metastasis (N-stage), tumor staging (T) and survival time in LSCC patients...
March 9, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29519647/transoral-robotic-surgery-for-the-treatment-of-laryngeal-chondrosarcoma-a-case-report
#20
Ashley J Guthrie, Raymond L Chai
IMPORTANCE: Transoral robotic surgery has revolutionized the practice of head and neck surgery over the past decade, with indications now expanding to include laryngeal pathology. Although laryngeal chondrosarcoma is a rare entity, trends in otolaryngology literature suggest that it can frequently be managed with conservative approaches. We hope to inspire other head and neck surgeons to consider transoral robotic surgery for the treatment of such tumors so that outcomes data can be collected and studied...
March 1, 2018: American Journal of Otolaryngology
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