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https://www.readbyqxmd.com/read/29913153/pag1-promotes-the-inherent-radioresistance-of-laryngeal-cancer-cells-via-activation-of-stat3
#1
Li Shen, Qing Ke, Jingjing Chai, Chuanyi Zhang, Li Qiu, Feng Peng, Xinzhou Deng, Zhiguo Luo
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1(PAG1) is a ubiquitous protein that is essential for the development and progression of various malignancies. A previous study in our laboratory confirmed that PAG1 plays an important role in modulating the inherent radioresistance of laryngeal cancer cells, but the underlying mechanisms are still poorly defined. In this study, we found that PAG1 was significantly increased in laryngeal cancer tissues compared to adjacent non-tumor tissues (P < 0...
June 15, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29909903/systemic-therapy-in-non-conventional-cancers-of-the-larynx
#2
REVIEW
Elaine Tan, Mayur D Mody, Nabil F Saba
Laryngeal cancer (LC) remains a challenging disease to treat. The majority of LCs diagnosed worldwide are squamous cell carcinomas (SCC), and current treatment guidelines are designed to address conventional laryngeal SCC. However, several histologically rare tumor types can originate in the larynx. There is a lack of guidelines regarding the best therapeutic approaches to these tumors and their treatment is often modeled after their recommended management at non-laryngeal sites. Understanding the role for systemic therapy in these rare tumors is important, especially for patients with advanced disease or those who are not surgical candidates...
July 2018: Oral Oncology
https://www.readbyqxmd.com/read/29900085/target-volume-delineation-using-diffusion-weighted-imaging-for-mr-guided-radiotherapy-a-case-series-of-laryngeal-cancer-validated-by-pathology
#3
Hans Ligtenberg, Tim Schakel, Jan Willem Dankbaar, Lilian N Ruiter, Boris Peltenburg, Stefan M Willems, Nicolien Kasperts, Chris H J Terhaard, Cornelis P J Raaijmakers, Marielle E P Philippens
In radiotherapy treatment planning, tumor delineation based on diffusion-weighted imaging (DWI) by magnetic resonance imaging (MRI) is a promising technique. MR-only-based target definition becomes important with the recent development of MRI integrated radiotherapy treatment modalities. In this case series, DWI-based gross tumor volume (GTV) was validated using pathology and compared with a clinical GTV based on computed tomography (CT) imaging and MRI. This case series includes three patients with a laryngeal tumor...
April 11, 2018: Curēus
https://www.readbyqxmd.com/read/29884508/prevalence-of-dysphagia-in-patients-with-non-neoplastic-vocal-fold-pathology
#4
Abdul-Latif Hamdan, Elie Khalifee, Hussein Jaffal, Anthony Ghanem, Samer Abou Rizk, Aya El Hage
OBJECTIVES: To examine the prevalence of dysphagia in patients presenting with dysphonia and diagnosed with non-neoplastic vocal fold pathology. METHODS: A total of 45 patients presenting with dysphonia and diagnosed with non-neoplastic vocal fold pathology and a control group matched according to age and gender were included. Patients with recent history of respiratory tract infection, laryngeal surgery or manipulation, neurologic disorders, head and neck tumors, or history of chemotherapy/radiotherapy were excluded...
June 5, 2018: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/29884412/comparative-genomic-analysis-of-oral-versus-laryngeal-and-pharyngeal-cancer
#5
David M Vossen, Caroline V M Verhagen, Marcel Verheij, Lodewyk F A Wessels, Conchita Vens, Michiel W M van den Brekel
OBJECTIVE: Locally advanced oral squamous cell carcinoma (OSCC) shows lower locoregional control and disease specific survival rates than laryngeal and pharyngeal squamous cell carcinoma (L/P-SCC) after definitive chemoradiotherapy treatment. Despite clinical factors, this can point towards a different tumor biology that could impact chemoradiotherapy response rates. This prompted us to compare the mutational profiles of OSCC with L/P-SCC. METHODS: We performed target capture DNA sequencing on 111 HPV-negative HNSCC samples (NKI dataset), 55 oral and 56 laryngeal/pharyngeal, and identified somatic point mutations and copy number aberrations...
June 2018: Oral Oncology
https://www.readbyqxmd.com/read/29878389/long-term-outcomes-of-530-esophageal-squamous-cell-carcinoma-patients-with-minimally-invasive-ivor-lewis-esophagectomy
#6
Wang Qi, Wu Zixiang, Zhan Tianwei, Fang Shuai, Zhang Sai, Shen Gang, Wu Ming
BACKGROUND AND OBJECTIVES: The short-term benefits of minimally invasive esophagectomy (MIE) Ivor Lewis were proved, but 6-year outcomes in esophageal squamous cell carcinoma (ESCC) patients remain unclear. We sought to investigate perioperative outcomes, quality of life (QOL), survival and impact of adjuvant therapy in ESCC patients who underwent MIE Ivor Lewis. METHODS: We conducted a retrospective review of 530 ESCC patients treated with MIE Ivor Lewis from 2011 to 2016...
April 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29878161/prognostic-role-of-p16-in-nonoropharyngeal-head-and-neck-cancer
#7
Alex K Bryant, Elena J Sojourner, Lucas K Vitzthum, Kaveh Zakeri, Hanjie Shen, Cammie Nguyen, James D Murphy, Joseph A Califano, Ezra E W Cohen, Loren K Mell
Background: Previous studies have reported conflicting information regarding the prognostic role of p16 in nonoropharyngeal head and neck squamous cell carcinoma (HNSCC). Methods: Using the US Veterans Affairs database, we analyzed 1448 patients with locoregionally advanced HNSCC and known p16 status diagnosed between 2005 and 2015 and treated with surgery, radiotherapy, or chemoradiotherapy. Tumor p16 status was determined through manual review of pathology reports of primary tumor specimens...
June 5, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29876330/predictors-of-thyroid-gland-invasion-in-laryngeal-squamous-cell-carcinoma
#8
Keyvan Aghazadeh, Sasan Dabiri Satri, Amirsina Sharifi, Maryam Lotfi, Bita Maraghehpour, Arsalan Hashemiaghdam
Introduction: Laryngeal squamous cell carcinoma (SCC) can invade the thyroid gland leading to unnecessary thyroidectomies with subsequent hypothyroidism and hyperparathyroidism. Thus, clinicopathological variables should be defined in order to predict thyroid gland invasion preoperatively. Materials and Methods: We performed a retrospective analysis of 1,465 patients with laryngeal SCC referred to our center between March 2009 and January 2016. Among these patients, 60 individuals underwent total laryngectomy and either thyroid lobectomy and isthmectomy or total thyroidectomy...
May 2018: Iranian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/29874469/mir-154-inhibits-the-growth-of-laryngeal-squamous-cell-carcinoma-by-targeting-the-galnt7
#9
Jun-Tao Niu, Li-Jun Zhang, Yong-Wang Huang, Chao Li, Ning Jiang, Yuan-Jie Niu
MicroRNAs are critical regulators of the development and progression of laryngeal squamous cell carcinoma (LSCC). However, the role of microRNA-154 (miR-154) in the development and progression of LSCC has not been clarified. We found that down-regulated miR-154 expression in LSCC tissues was associated with poorer prognosis in LSCC patients. MiR-154 over-expression inhibited the proliferation, clonogenicity and migration of LSCC cells and induced their cell cycle arrest, which were reversed by miR-154 inhibition...
June 6, 2018: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/29873209/-retrospective-analysis-of-760-laryngeal-squamous-cell-carcinoma-patients-treated-with-open-laryngeal-function-preserving-operations
#10
L Tao, L Zhou, H T Wu, X M Li, X L Chen, C Li, M Xie, M Zhang, L Cheng, D Tang
Objective: To explore the fundamental clinical characteristics and survival prognostic factors of laryngeal squamous cell carcinoma (LSCC) patients treated with open laryngeal function-preserving operations. Method: The collected clinical data and the follow-up survival information from 760 patients with LSCC undergoing open laryngeal function-preserving operations between January 2005 and December 2010 in Eye & ENT Hospital of Fudan University were retrospectively analyzed. Kaplan-Meier was applied to calculate survival rates...
May 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29869708/oncological-and-functional-outcomes-of-transoral-laser-surgery-for-laryngeal-carcinoma
#11
Daniel Pedregal-Mallo, Mario Sánchez Canteli, Fernando López, César Álvarez-Marcos, José Luis Llorente, Juan Pablo Rodrigo
INTRODUCTION: Transoral laser microsurgery (TLM) has become the standard approach for treatment of early-stage laryngeal carcinoma in most institutions due to their good oncological and functional results with few local complications. The purpose of this study was to analyze the oncological and functional results of TLM in the treatment of laryngeal tumors at our Hospital. MATERIALS AND METHODS: Patients with laryngeal squamous cell carcinoma (LSCC) treated from 1998 to 2013 with TLM with curative intention, and with a minimum follow-up of 24 months, were reviewed...
June 5, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29864898/mir-125b-5p-suppressed-the-glycolysis-of-laryngeal-squamous-cell-carcinoma-by-down-regulating-hexokinase-2
#12
Lian Hui, Jingru Zhang, Xing Guo
Laryngeal squamous cell carcinoma (LSCC) is the most common form of laryngeal carcinoma with poor prognosis. Exploring novel factors involved in the progression of LSCC is quite necessary for understanding the mechanisms and designing therapeutic strategies for LSCC. In this study, we showed that miR-125b-5p was significantly down-regulated in LSCC tissues and cell lines. The decreased expression of miR-125b-5p was associated with the tumor differentiation, metastasis and high clinical stage of the LSCC patients...
July 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29858797/assessment-of-tumor-response-to-chemoradiotherapy-and-predicting-prognosis-in-patients-with-head-and-neck-squamous-cell-carcinoma-by-percist
#13
Takayuki Katsuura, Kazuhiro Kitajima, Masayuki Fujiwara, Tomonori Terada, Nobuhiro Uwa, Kazuma Noguchi, Hiroshi Doi, Yukihisa Tamaki, Rika Yoshida, Tatsuya Tsuchitani, Masahiro Fujita, Koichiro Yamakado
PURPOSE: To evaluate therapeutic response to chemoradiotherapy and prediction of recurrence and death in patients with head and neck squamous cell carcinoma (HNSCC) using Positron Emission Tomography Response Criteria in Solid Tumors (PERCIST). MATERIALS AND METHODS: Forty-two patients (mean 63.4, range 20-79 years) with nasopharyngeal (n = 10), oropharyngeal (n = 13), hypopharyngeal (n = 11), or laryngeal (n = 8) cancer underwent fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) before and approximately 3 months (mean 95...
June 1, 2018: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/29843929/microrna-4497-functions-as-a-tumor-suppressor-in-laryngeal-squamous-cell-carcinoma-via-negatively-modulation-the-gbx2
#14
Xudong Chen, Litao Zhang, Shixiong Tang
OBJECTIVE: MicroRNAs (miRNAs) are aberrantly expressed in various tumors and play a critical role in the progression and development of tumors. However, there is little information about the role of miR-4497 in laryngeal squamous cell carcinoma (LSCC). The aim of this study is to investigate the role of miR-4497 in LSCC. METHODS: MiR-4497 expression in tumor tissues and adjacent normal tissues was measured by RT-PCR. The effects of miR-4497 on cell viability and apoptosis were evaluated by the MTT assay, Flow cytometry and caspase-3 activity assay...
May 26, 2018: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29806412/-applications-of-one-stage-total-spondylectomy-by-anterior-and-posterior-approaches-for-solitary-plasmacytoma-of-cervical-spine
#15
Minhao Wu, Lin Cai, Feifei Yan, Keke Xu, Wenchao Sun, Zhouming Deng, Yuanlong Xie
Objective: To investigate the feasibility of one-stage total spondylectomy by anterior and posterior approaches for treating solitary plasmacytoma (SP) of cervical spine. Methods: Between June 2000 and March 2015, the clinical data, diagnosis, and treatment of 12 patients with SP of cervical spine were retrospectively analyzed. There were 8 males and 4 females, with a mean age of 46 years (range, 28-74 years). The mean disease duration was 8.4 months (range, 3-15 months)...
February 1, 2018: Chinese Journal of Reparative and Reconstructive Surgery
https://www.readbyqxmd.com/read/29800964/patterns-of-tobacco-cessation-attempts-and-symptoms-experienced-among-smokers-with-head-and-neck-squamous-cell-carcinoma
#16
Samir S Khariwala, Dorothy K Hatsukami, Irina Stepanov, Nathan Rubin, Heather H Nelson
Importance: Among smokers with head and neck squamous cell carcinoma (HNSCC), there is ample evidence regarding the benefits of smoking cessation prior to treatment. Prior data indicates that increased attempts at cessation result in higher likelihood of cessation after diagnosis but the prediagnostic patterns of smoking cessation attempts among those smokers developing HNSCC has not been characterized. Data of this kind may direct cessation efforts toward increased efficacy. Objective: To determine the frequency and character of tobacco cessation attempts and symptoms experienced prior to development of HNSCC, as well as to determine the correlation of these symptoms with number of cessation attempts and maximum quit days...
April 12, 2018: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29800033/feasibility-of-bioengineered-tracheal-and-bronchial-reconstruction-using-stented-aortic-matrices
#17
Emmanuel Martinod, Kader Chouahnia, Dana M Radu, Pascal Joudiou, Yurdagul Uzunhan, Morad Bensidhoum, Ana M Santos Portela, Patrice Guiraudet, Marine Peretti, Marie-Dominique Destable, Audrey Solis, Sabiha Benachi, Anne Fialaire-Legendre, Hélène Rouard, Thierry Collon, Jacques Piquet, Sylvie Leroy, Nicolas Vénissac, Joseph Santini, Christophe Tresallet, Hervé Dutau, Georges Sebbane, Yves Cohen, Sadek Beloucif, Alexandre C d'Audiffret, Hervé Petite, Dominique Valeyre, Alain Carpentier, Eric Vicaut
Importance: Airway transplantation could be an option for patients with proximal lung tumor or with end-stage tracheobronchial disease. New methods for airway transplantation remain highly controversial. Objective: To establish the feasibility of airway bioengineering using a technique based on the implantation of stented aortic matrices. Design, Setting, and Participants: Uncontrolled single-center cohort study including 20 patients with end-stage tracheal lesions or with proximal lung tumors requiring a pneumonectomy...
May 20, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29798516/-advances-in-the-regulation-of-lncrna-on-laryngeal-squamous-cell-carcinoma
#18
REVIEW
X B Liang, J T Lang, Y H Liu
Laryngeal cancer (LC) is one of the most common malignant tumors that occur in the head and neck. Emerging evidence shows that coding RNAs and non-coding RNAs play key roles in the formation and progression of LC. In this review, we focus on the regulation of lncRNAs in LC. LncRNAs appear to be involved in laryngeal cancer growth, invasion, and metastasis and in establishment of the laryngeal tumor microenvironment through various mechanisms. Furthermore, we also discuss the possibilities of establishing lncRNAs as potential biomarkers and therapeutic targets for laryngeal cancer...
February 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29798388/-the-effect-of-regional-neck-dissection-on-positive-cervical-lymph-node-of-cn0-laryngeal-carcinoma
#19
X Y Li, J R Li, H G Guo
Objective: To evaluate the efficacy and safety of regional neck dissection in the treatment of cN0 laryngeal carcinoma with positive cervical lymph node. Method: A retrospective analysis of 120 cases with cN0 laryngeal squamous cell carcinoma who received the first time for primary tumor resection and regional neck dissection (Ⅱ-Ⅳ) in our hospital during the period of 2000.01-2016.06 were performed. Twenty-two patients with lymph node positive (pN+) were selected by postoperative paraffin pathology in Ⅱ-Ⅳ region and followed up to 2017...
December 5, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29798360/-laryngeal-undifferentiated-soft-tissue-sarcoma-a-case-report-and-review-of-literature
#20
Y B Dong, L F Liu, L Y Xue, C Lu
Patient presented as a 74-year-old male complaining of hoarseness. Electronic laryngoscope showed a neoplasm whose size was about 1.0 cm×0.5 cm×0.5 cm at anterior commissure. A surgery was conducted to excise the neoplasm en bloc. The histopathological and immunohistochemistry examination suggested inflammatory myofibroblastic tumor. A month later, the patient presented with dyspnea and blood-stained sputum. CT scan of neck showed an occupation lesions under glottis. A tracheotomy and a CO₂ laser surgery was conducted due to patient's will...
August 5, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
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