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https://www.readbyqxmd.com/read/27920556/the-prognostic-value-of-systemic-and-local-inflammation-in-patients-with-laryngeal-squamous-cell-carcinoma
#1
Jie Wang, Shengzi Wang, Xinmao Song, Wenjiao Zeng, Shuyi Wang, Fu Chen, Hao Ding
BACKGROUND: Cancer-related systemic inflammation has been demonstrated to be associated with poor outcome in multiple types of cancers. Meanwhile, the local inflammation, which is characterized by dense intratumoral immune infiltrate, is a favorable predictor of survival outcome. PURPOSE: To evaluate the role of systemic and local inflammation in predicting outcome in patients with laryngeal squamous cell carcinoma. PATIENTS AND METHODS: In this retrospective study, 120 patients who had undergone postoperative radiotherapy were enrolled...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27919993/laryngo-esophageal-dysfunction-free-survival-in-a-preservation-protocol-for-t3-laryngeal-squamous-cell-carcinoma
#2
Philippe Gorphe, Margarida Matias, Caroline Even, Charles Ferte, François Bidault, Gabriel Garcia, Stéphane Temam, France Nguyen, Pierre Blanchard, Yungan Tao, François Janot
BACKGROUND: We reviewed the outcomes of patients with T3 laryngeal neoplasms with a fixed hemilarynx, a large gross tumor volume or a subglottic extension (SGE), treated with a laryngeal-preservation protocol with induction chemotherapy. PATIENTS AND METHODS: The study end-points were laryngo-esophageal dysfunction-free survival (LEDFS), laryngectomy-free survival (LFS), overall survival (OS), and disease-free survival (DFS). RESULTS: A total of 104 patients were included...
December 2016: Anticancer Research
https://www.readbyqxmd.com/read/27916735/laryngeal-mucus-hypersecretion-is-exacerbated-after-smoking-cessation-and-ameliorated-by-glucocorticoid-administration
#3
Rumi Ueha, Satoshi Ueha, Kenji Kondo, Takaharu Nito, Yoko Fujimaki, Hironobu Nishijima, Koichi Tsunoda, Francis H W Shand, Kouji Matsushima, Tatsuya Yamasoba
INTRODUCTION: The mechanisms underlying the effects of cigarette smoke and smoking cessation on respiratory secretion, especially in the larynx, remain unclear. OBJECTIVES: The aims of this study were to determine the effects of cigarette smoke and smoking cessation on laryngeal mucus secretion and inflammation, and to investigate the effects of glucocorticoid administration. METHODS: We administered cigarette smoke solution (CSS) to eight-week-old male Sprague Dawley rats for four weeks, then examined laryngeal mucus secretion and inflammatory cytokine expression on days 1, 28 and 90 after smoking cessation...
December 1, 2016: Toxicology Letters
https://www.readbyqxmd.com/read/27909719/the-expression-and-function-of-epithelial-membrane-protein-1-in-laryngeal-carcinoma
#4
Hong Li, Xiaowen Zhang, Xuejun Jiang, Xu Ji
In this study, we compared the expression of epithelial membrane protein 1 (EMP1) on the steady-state mRNA level (by quantitative real-time PCR) and on the protein level (by western immunoblot and immunohistochemistry) in 51 pairs of laryngeal carcinoma tissues and matched cancer-free peritumor tissues, and we analyzed the correlation between EMP1 expression and different clinicopathological factors. Furthermore, we ectopically expressed EMP1 in human laryngeal carcinoma Hep-2 cells and examined the effects on cell viability, apoptosis, colonogenicity, and motility, by MTT assay, flow cytometry, colony formation assay and Transwell migration assay, respectively...
November 28, 2016: International Journal of Oncology
https://www.readbyqxmd.com/read/27902487/identification-of-laryngeal-cancer-prognostic-biomarkers-using-an-inflammatory-gene-related-competitive-endogenous-rna-network
#5
Qun He, Linli Tian, Hao Jiang, Jiarui Zhang, Qiang Li, Yanan Sun, Jiannan Zhao, Huijun Li, Ming Liu
Competitive endogenous RNAs (ceRNAs) act as molecular sponges for microRNAs (miRNAs), and are associated with tumorigenesis in various cancers, including laryngeal cancer (LC). In this work, we constructed an LC-specific inflammatory gene-related ceRNA network (IceNet). In IceNet, ceRNAs targeting inflammation-related genes tended to be network hubs. Additionally, the betweenness centralities of these hub ceRNAs were higher than those of the inflammation-related genes themselves, indicating that the hub ceRNAs in this study played critical roles in communication between IceNet molecules...
November 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27898173/an-update-on-larynx-cancer
#6
REVIEW
Conor E Steuer, Mark El-Deiry, Jason R Parks, Kristin A Higgins, Nabil F Saba
Answer questions and earn CME/CNE Laryngeal cancer remains one of the most common tumors of the respiratory tract. Fortunately, significant advancements have been made over the past decade in the treatment of laryngeal cancer. Although surgery has been the historical mainstay for localized disease and still is an integral part of treatment, nonsurgical options like radiation and systemic therapy have emerged as viable options. In addition, in the metastatic setting, novel agents are showing promise for this patient population...
November 29, 2016: CA: a Cancer Journal for Clinicians
https://www.readbyqxmd.com/read/27895741/the-prognostic-significance-of-estrogen-receptor-%C3%AE-in-head-and-neck-squamous-cell-carcinoma
#7
Kresimir Grsic, Iva Ledinsky Opacic, Sanda Sitic, Marija Milkovic Perisa, Petar Suton, Bozena Sarcevic
Head and neck squamous cell carcinoma (HNSCC) is the fifth most common cancer in the world. Although multimodal and targeted therapy is now used in therapeutic procedures, the survival of patients with HNSCC has remained unchanged over the last 30 years. A number of studies have demonstrated that the increased expression of intranuclear ERβ in breast, lung and colon cancer is a favorable prognostic marker associated with higher survival rates. However, the clinical significance of sex hormone receptors in HNSCC remains unclear...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27888826/clinical-significance-of-ki-67-c-erbb-2-and-e-cadherin-expressions-in-open-partial-laryngectomy-patients
#8
Ozan Barutçu, Medine Kara, Aslı Muratlı, Oğuz Güçlü, Sefa Dereköy
OBJECTIVES: This study aims to analyze the correlation between biomarkers and risks of cervical lymph node invasion, recurrence, distant metastasis and survival regarding the clinicopathological variables in laryngeal cancers. PATIENTS AND METHODS: Forty-one patients with laryngeal cancers were examined retrospectively. The correlations evaluated between E-cadherin, Ki-67, c-erbB-2 expressions, tumor site, differentiation, the risk of cervical lymph node metastasis, perineural, perivascular, pericapsular invasion and recurrence as well as survival time...
September 2016: Kulak Burun Boğaz Ihtisas Dergisi: KBB, Journal of Ear, Nose, and Throat
https://www.readbyqxmd.com/read/27882174/reduction-of-p38-mitogen-activated-protein-kinase-and-cyclooxygenase-2-signaling-by-isoflurane-inhibits-proliferation-and-apoptosis-evasion-in-human-papillomavirus-infected-laryngeal-papillomas
#9
Hongbo Ren, Xiaojuan Shi, Ying Li
Human laryngeal papilloma (LP) is a human papillomavirus-induced hyperplastic tumor of the respiratory tract, which is characterized by rapid growth and apoptosis resistance. Isoflurane (ISO) inhibits proliferation and elicits apoptosis in cancer cells. The results of the present study found that the mRNA and protein levels of cyclooxygenase-2 (COX2) were higher in LP tissues than in normal laryngeal samples, and prostaglandin E2 (PGE2) production was increased in LP cells, as determined by quantitative polymerase chain reaction, western blot and radioimmunoassay analyses...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27882007/therapeutic-effects-of-sequential-chemoradiotherapy-with-pemetrexed-and-cisplatin-on-locally-advanced-laryngeal-cancer
#10
Youmao Tao, Chong Ma, Xiangdang Yin, Xuedong Fang, Lixiu Liu
OBJECTIVE: To explore the therapeutic effects of sequential chemoradiotherapy with pemetrexed and cisplatin on locally advanced laryngeal cancer (LALC). METHODS: Fifty LALC patients who were treated in our hospital between January 2010 and January 2012 were selected and randomly divided into an observation group and a control group (n=25). The two groups were given conventional radiotherapy in the same manner, before which two cycles of chemotherapy were performed...
September 2016: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/27880721/inhibition-of-hax-1-by-mir-125a-reverses-cisplatin-resistance-in-laryngeal-cancer-stem-cells
#11
Jiajia Liu, Qinglai Tang, Shisheng Li, Xinming Yang
Chemoresistance is a major obstacle in chemotherapy of laryngeal carcinoma. Recently, studies indicate that cancer stem cells are responsible for chemotherapy failure. In addition, microRNAs play important roles in tumor initiation, development and multidrug resistance. In the present study, we found that the expression of microRNA-125a was decreased in laryngeal carcinoma tissues and Hep-2 laryngeal cancer stem cells (Hep-2-CSCs). MicroRNA-125a gain-of-function significantly increased the sensitivity of Hep-2-CSCs to cisplatin in vitro and in vivo...
November 17, 2016: Oncotarget
https://www.readbyqxmd.com/read/27874955/expression-and-significances-of-mirna-let-7-and-hmga2-in-laryngeal-carcinoma
#12
F-C Song, Y Yang, J-X Liu
OBJECTIVE: High mobility group protein A2 (HMGA2) is a reported new oncogene been regulated by tumor suppressor microRNA Let-7. HMGA2 has become a hot topic in fundamental and clinical research of laryngeal carcinoma. The aim of the current study is to investigate the molecular mechanism of Let-7 and HMGA2 in oncogenesis and progression of laryngeal cancer. PATIENTS AND METHODS: We used quantitative RT-PCR to detect the expression of miRNA Let-7a and HMGA2 mRNA from 59 pairs of fresh laryngeal cancer tissues and adjacent tissues collected for the laryngeal cancer patient...
November 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27868407/-effect-of-dj-1-silencing-by-rna-interference-on-growth-of-xenografted-human-laryngeal-squamous-cell-carcinoma-hep-2-cells-in-nude-mice
#13
Zhisen Shen, Hongxia Deng, Dong Ye, Jian Zhang, Shijie Qiu, Qun Li, Xiang Cui
Objective: To investigate the effect of silencing DJ-1 on xenografted human laryngeal squamous cell carcinoma (LSCC) Hep-2 cells in nude mice. Methods: Xenograft model of human LSCC was established by subcutaneous transplantation of Hep-2 cells in 24 nude mice. The LSCC-bearing nude mice were randomly divided into 3 groups (n=8 in each):DJ-1 siRNA low dose group and DJ-1 siRNA high dose group were injected in tumors with 20 μg of DJ-1 siRNA or 40 μg of DJ-1 siRNA in 50 μL, respectively; control group was injected with 5% glucose solution in 50 μL, twice a week for 3 weeks...
May 25, 2016: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
https://www.readbyqxmd.com/read/27867556/recurrent-laryngeal-nerve-lymph-node-dissection-may-not-be-suitable-for-all-early-stage-esophageal-squamous-cell-carcinoma-patients-an-8-year-experience
#14
Shaobin Yu, Jihong Lin, Chenshu Chen, Jiangbo Lin, Ziyang Han, Wenwei Lin, Mingqiang Kang
BACKGROUND: Recurrent laryngeal nerve (RLN) injury is one of the most frequent postoperative complications of esophageal squamous cell carcinoma (ESCC) radical resection. This study aims to develop a novel scoring system to predict recurrent laryngeal nerve lymph node (RLNLN) metastases in early ESCC and explore the indications for precise RLN lymphadenectomy. METHODS: Early stage ESCC patients from 2006 to 2014 were analyzed. Patient and pathologic characteristics were compared between patients with RLNLN metastases and those without...
October 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27865371/assessing-head-and-neck-cancer-patient-preferences-and-expectations-a-systematic-review
#15
REVIEW
Pierre Blanchard, Robert J Volk, Jolie Ringash, Susan K Peterson, Katherine A Hutcheson, Steven J Frank
INTRODUCTION: To enhance the value of care, interventions should aim at improving endpoints that matter to patients. The preferences of head and neck cancer patients regarding treatment outcomes are therefore a major topic for patient-centered research. METHODS: A systematic review (PROSPERO number CRD42016035692) was conducted by searching electronic databases (Medline, Embase, Cochrane, CINAHL) for articles evaluating patient or surrogate preferences in head and neck cancer...
November 2016: Oral Oncology
https://www.readbyqxmd.com/read/27859417/runx3-inhibits-laryngeal-squamous-cell-carcinoma-malignancy-under-the-regulation-of-mir-148a-3p-dnmt1-axis
#16
Su Jili, Lu Eryong, Lu Lijuan, Zhang Chao
Laryngeal squamous cell carcinoma (LSCC) is a highly aggressive malignant cancer and accounts for 1% to 2% of all malignancies diagnosed worldwide. Runt-related transcription factor 3 (RUNX3), an important tumor suppressor, is known to related to lymph node metastasis and the development of LSCC. However, the biological roles and potential mechanisms RUNX3 expression was not well understood. In this study, we reported that the RUNX3 was significantly downregulated and highly methylated in LSCC compared with their matched normal...
November 15, 2016: Cell Biochemistry and Function
https://www.readbyqxmd.com/read/27855370/cd47-is-a-potential-target-for-the-treatment-of-laryngeal-squamous-cell-carcinoma
#17
ChunPing Yang, ShuFeng Gao, HaiZhen Zhang, Lian Xu, JianGuo Liu, Meiqun Wang, ShaoRong Zhang
BACKGROUND/AIMS: This study aims to investigate the effect of CD47 on the development of laryngeal squamous cell carcinoma (LSCC) and the therapeutic potential of monoclonal antibody against CD47 and its ligand SIRPα in the treatment of LSCC. METHODS: We firstly detected the expressions of CD47 mRNA and protein in LSCC and para-carcinoma tissues, introduced the most efficient CD47siRNA sequence into LSCC cells by lentiviral transfection and employed three monoclonal antibodies to evaluate their anti-LSCC effects in vitro and in vivo...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27846184/minimal-endoscope-assisted-thyroidectomy-through-a-retroauricular-approach-an-evolving-solo-surgery-technique
#18
Myung Jin Ban, Jae Won Chang, Won Shik Kim, Hyung Kwon Byeon, Yoon Woo Koh, Jae Hong Park
This study aimed to evaluate the feasibility and efficacy of minimal endoscope-assisted thyroidectomy (MEAT) through a retroauricular (RA) approach. Most of the thyroidectomy operative time was accounted for by direct visualization through the RA window, minimizing interference between surgical instruments. Endoscope use was minimized and limited to critical surgical aspects, including preservation of the recurrent laryngeal nerve and parathyroid glands. The recurrent laryngeal nerve was neuromonitored throughout the procedure...
November 11, 2016: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/27833963/anterior-commissure-laryngeal-neoplasm-endoscopic-management
#19
Nicolae Constantin Balica, Mărioara Poenaru, Eugen HoraŢiu Ştefănescu, Eugen Radu Boia, Caius Ion Doroş, Flavia Baderca, Octavian Mazilu
The CO2 laser surgery represents a treatment method of laryngeal bicordal and anterior commissure glottic cancer T1b, T2, N0. In Department of ENT, Timisoara, Romania, during 1.01.2001-31.12.2011 were analyzed 781 files from patients with laryngeal neoplasm. One hundred twenty-seven patients presented the tumor that involved both vocal cords and anterior commissure, stages T1b, T2 and T3. Therapeutic options included CO2 laser microsurgical excision for 55 (43.30%) patients, frontolateral hemilaryngectomy for 16 (12...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/27833496/unusual-cause-of-bilateral-vocal-cord-paralysis
#20
W M Hajjar, H A AlShalan, M A Alsowayyan, S A Al-Nassar
The most common cause of vocal cord paralysis (VCP) as a result of recurrent laryngeal nerve compression is malignant tumors. A benign and inflammatory causes of VCP is rarely reported in the literature, and in almost all reported cases it was a unilateral paralysis. We report a rare case of tuberculous mediastinal lymphadenopathy causing bilateral VCP in a young female patient.
October 2016: Saudi Journal of Anaesthesia
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