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https://www.readbyqxmd.com/read/28217048/radiofrequency-ablation-of-hepatocellular-carcinomas-a-new-spectrum-of-anesthetic-experience-at-a-tertiary-care-hospital-in-pakistan
#1
Faisal Shamim, Ali Asghar, Saman Tauheed, Muhammad Yahya
BACKGROUND: Radiofrequency ablation (RFA) is a minimally invasive technique of tumor destruction for patients with hepatic cancer who are not candidates for conventional therapy. The therapy required general anesthesia (GA) or sedation to ensure patient safety and comfort. The study is aimed to report and evaluate factors that influenced the periprocedural anesthetic management, drugs used, and complications during and immediately after RFA procedure for hepatocellular carcinoma. METHODS: For this retrospective study, we included 46 patients who underwent percutaneous RFA under GA or conscious sedation from January 2010 to June 2013 in Aga Khan University Hospital, Pakistan...
January 2017: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/28217020/correlation-of-positron-emission-tomography-computed-tomography-scan-with-smoking-tumor-size-stage-and-differentiation-in-head-and-neck-cancer-patients
#2
Jordan L Pleitz, Partha Sinha, Emily V Dressler, Rony K Aouad
The goal of this study was to identify associations between positron emission tomography/computed tomography (PET/CT) maximum standardized uptake value (SUVmax) in patients presenting with head and neck squamous cell carcinoma (SCC) with tumor site, size, histologic differentiation, smoking, and diabetes. Charts of patients with oropharyngeal and laryngeal SCC who underwent (18)F-fluorodeoxyglucose PET/CT scans were reviewed between May 2007 and August 2013. Statistical analyses included modeling log-transformed SUVmax values by tumor site, size, histologic differentiation, smoking status, and diabetes using unadjusted linear regressions...
January 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28207586/open-partial-laryngectomy-after-failure-of-chemo-radiation-indications-oncologic-and-functional-outcomes
#3
Geoffrey Mortuaire, Dominique Chevalier, François Mouawad
PURPOSE OF REVIEW: Early-stage squamous cell carcinoma of the larynx can be successfully treated with radiotherapy or surgery (transoral or open approaches). Oncologic results are comparable while functional results may be different according to the volume of resection. In some countries radiotherapy is often preferred as primary treatment. In case of recurrence, surgical salvage is the only option. Careful examination, endoscopic assessment, computed tomography or magnetic resonance imaging are necessary to assess superficial and deep extensions into the larynx, including cartilage framework and to restage the tumor...
February 15, 2017: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/28194664/phrenic-nerve-stimulation-during-neck-dissection-for-advanced-thyroid-cancer-involving-level-iv-is-it-worth-doing-it
#4
Carlos S Duque, Juan P Dueñas, Marcela Marulanda, Diana Pérez, Andres Londoňo, Soham Roy, Mai Al Khadem
During thyroidectomy and neck dissection surgery for advanced or recurrent metastatic thyroid cancer under intraoperative monitoring, we used the available technology to assess the feasibility of such an intervention to monitor those patients with phrenic nerves at risk. A retrospective review of patients operated on from January 2009 to December 2015 by a single surgeon (CSD) was conducted. Patients who had neck and mediastinal dissection, with or without total thyroidectomy, due to advanced or recurrent metastatic disease to the neck were selected...
February 13, 2017: Updates in Surgery
https://www.readbyqxmd.com/read/28188026/clinical-significance-of-integrin-linked-kinase-in-laryngeal-squamous-cell-carcinoma
#5
Ping-An Wu, Shi-Sheng Li, Qing-Lai Tang, Bing-Bing Liu, Xin-Ming Yang
OBJECTIVE: To investigate the expression of integrin-linked kinase (ILK) and its relationship with clinicopathological parameters in laryngeal squamous cell carcinoma (LSCC). METHODS: 116 patients who had previously undergone complete resection of tumor for LSCC were studied retrospectively. The level of ILK expression in tumor tissues and adjacent nontumor tissues were determined by immunohistochemistry. RESULTS: Increased expression of ILK was found in 65...
February 7, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28185819/expression-of-polysialic-acid-in-primary-laryngeal-squamous-cell-carcinoma
#6
Marko Klobučar, Sarah Visentin, Antonija Jakovčević, Mario Bilić, Lana Kovač-Bilić, Davorin Đanić, Krešimir Pavelić, Sandra Kraljević Pavelić
AIMS: Expression of polySia is associated with metastatic dissemination and progression of various malignant diseases. In particular, it may contribute to tumorigenesis by a negative modulatory effect on cellular signaling cascades responsible for cellular migration, differentiation and proliferation. In this study, we investigated the expression of polySia in primary metastatic and non-metastatic laryngeal squamous cell carcinoma (LSCC) tumor tissues and its potential impact on the LSCC progression...
February 6, 2017: Life Sciences
https://www.readbyqxmd.com/read/28185009/relationship-between-the-time-to-locoregional-recurrence-and-survival-in-laryngeal-squamous-cell-carcinoma
#7
Philippe Gorphe, Yungan Tao, Pierre Blanchard, Caroline Even, Antoine Moya-Plana, Haïtham Mirghani, France Nguyen, Stéphane Temam, François Janot
To assess the relationship between the locoregional disease-free interval after treatment of the primary tumor and survival after a recurrence in patients with laryngeal carcinoma. We retrospectively investigated patients treated in our Cancer Center for a laryngeal cancer who subsequently developed a locoregional recurrence and were followed up until death. Post-recurrence survival was defined as the time from the locoregional recurrence to death. One hundred and twenty-three patients were included. Median post-recurrence survival was 7 months...
February 9, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28182829/transoral-endoscopic-thyroidectomy-vestibular-approach-toetva-from-a-to-z
#8
Gianlorenzo Dionigi, Matteo Lavazza, Alessandro Bacuzzi, Davide Inversini, Vincenzo Pappalardo, Ralph P Tufano, Hoon Yub Kim, Angkoon Anuwong
We depict the transoral endoscopic thyroidectomy vestibular approach (TOETVA). Patient selection criteria are (1) ultrasonographically (US) estimated thyroid diameter no larger than 10cm, (2) US estimated gland volume ≥45mL, (3) nodule size ≥5mm, (4) a benign tumor, such as a thyroid cyst, single-nodular goiter, or multinodular goiter, (5) follicular neoplasm, and (6) papillary microcarcinoma without evidence of metastasis. TOETVA is carried out through a three-port technique placed at the oral vestibule, one 10mm port for 30° endoscope and two additional 5mm ports for dissecting and coagulating instruments...
February 7, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/28166396/elmo3-predicts-poor-outcome-in-t1-laryngeal-cancer
#9
Georg Haymerle, Lorenz Kadletz, Robert Wiebringhaus, Bahar Golabi, Michael Mildner, Dietmar Thurnher, Gregor Heiduschka
OBJECTIVES: Despite the excellent overall survival of 92-97% in early glottic cancer, recurrence rates of 13-20% have not improved in the last decades. The engulfment and cell motility protein 3 (ELMO3) has been described as prognostic marker in lung cancer patients. The aim of this study was to investigate the expression of ELMO3 in early laryngeal cancer patients treated with TLM and to evaluate its prognostic significance on clinical outcome. DESIGN, SETTING AND PARTICIPANT: 48 patients with glottic carcinoma (T1N0M0) that underwent primary treatment with TLM between 1994 and 2012 were analyzed...
February 6, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28160429/the-role-of-sentinel-lymph-node-biopsy-in-the-management-of-laryngeal-carcinoma
#10
Mohamed T El Tabbakh, Mohamed Rifaat Ahmed, Yasser Taha Madian
Laryngeal carcinoma is considered as the most common head and neck neoplasm and the incidence of lymph node metastasis depends on the tumor stage. Sentinel Lymph Node Biopsy (SLNB) is an investigational tool in treatment of the clinical N0. The aim of the study is to determine the accuracy of sentinel lymph node biopsy (SLNB) in Laryngeal carcinoma and whether it can be used in the diagnostic and therapeutic approach to the clinical N0 neck. 47 patients were with Laryngeal carcinoma were divide into N0 group (20 patient) and N+ positive group (27 patients)...
February 3, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28153131/laryngeal-dysplasia-squamous-cell-carcinoma-and-variants
#11
REVIEW
Lester D R Thompson
Squamous cell carcinoma (SCC) is a malignant epithelial tumor showing evidence of squamous differentiation. It is the most common malignancy of the larynx, with several variants (verrucous, exophytic or papillary, spindle-cell, basaloid, acantholytic, adenosquamous) recognized, with well-established precursor lesions. Dysplasia is now separated into only low-grade and high-grade categories. Each SCC variant has unique cytomorphologic features and histologic differential diagnoses that are important to consider, as management and outcomes are different...
March 2017: Surgical Pathology Clinics
https://www.readbyqxmd.com/read/28152117/survival-rates-using-individualized-bioselection-treatment-methods-in-patients-with-advanced-laryngeal-cancer
#12
Gregory T Wolf, Emily Bellile, Avraham Eisbruch, Susan Urba, Carol R Bradford, Lisa Peterson, Mark E Prince, Theodoros N Teknos, Douglas B Chepeha, Norman D Hogikyan, Scott A McLean, Jeffery Moyer, Jeremy M G Taylor, Francis P Worden
Importance: Use of chemoradiotherapy for advanced laryngeal cancer led to a major shift in treatment as an alternative to laryngectomy. Despite widespread adoption of chemoradiotherapy, survival rates have not improved and the original premise of matching neoadjuvant chemotherapy tumor response to determine subsequent treatment has not been followed. Objective: To determine whether improved survival could be achieved by incorporating a single cycle of neoadjuvant chemotherapy to select patients with advanced disease for either laryngectomy or concurrent chemoradiotherapy...
February 2, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28149802/operative-bed-recurrence-of-thyroid-cancer-utility-of-a-preoperative-needle-localization-technique
#13
Oliver S Eng, Scott B Grant, Jason Weissler, Mitchell Simon, Sudipta Roychowdhury, Tomer Davidov, Stanley Z Trooskin
BACKGROUND: Surgical management of recurrent disease after total thyroidectomy and/or neck dissection for thyroid carcinoma remains a challenging clinical problem. Reoperation is associated with a significant increase in morbidity. Preoperative needle localization technique for non-palpable breast tumors has recently been extrapolated to head and neck surgery. We report on the use of preoperative ultrasound-guided needle localization for non-palpable recurrent operative bed disease as an intraoperative aid in resection...
December 2016: Gland Surgery
https://www.readbyqxmd.com/read/28147340/proposed-modifications-of-supraclavicular-lymph-node-metastasis-in-the-esophageal-squamous-cell-carcinoma-staging-system-for-improved-survival-stratification
#14
Yuzhen Zheng, Zhen Wang, Feng Wang, Qingyuan Huang, Shuoyan Liu
The present study aims to investigate the clinical implication of supraclavicular lymph nodes (SCLNs) in thoracic esophageal squamous cell carcinoma (ESCC). A total of 1156 ESCC patients who underwent three-field lymphadenectomy with node metastasis were analyzed retrospectively. SCLNs were defined as regional nodes in the current system or as distant nodes in the modified system. Survival was analyzed using the Kaplan-Meier method, and values were compared using the log-rank test. Multivariate analysis was performed using the Cox proportional hazard model...
January 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28139070/pediatric-laryngeal-carcinoma-in-a-heterozygous-carrier-of-fanconi-anemia
#15
A M D'Souza, J Mark, M Demarcantonio, D Leino, R Sisson, J I Geller
A case of invasive, keratinizing squamous cell carcinoma of the larynx in an 8-year-old female treated with laryngectomy is presented. Perinatal exposure to human papilloma virus and constitutional heterozygosity for a FANCC mutation were identified, though FANCC heterozygosity is not known to be cancer predisposing. An additional tumor-associated mutation in NOTCH1 was also identified potentially contributing to oncogenesis. This case illustrates an exceedingly rare type of cancer in the pediatric population and discusses diagnostic workup, evaluation of risk factors for head and neck cancer, and treatment options...
January 31, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28134697/massive-idiopathic-oropharyngeal-and-laryngeal-granulomatosis-on-fdg-pet-ct
#16
Yiyan Liu
Idiopathic granulomatosis is a rare entity and has varied manifestations and imaging findings. A 44-year-old woman with sore throat and worsening dyspnea had multiple oropharyngeal and supraglottic masses on laryngoscopic examination. FDG PET/CT demonstrated diffuse tumor-like mucosal/submucosal lesions with intense uptake involving the oropharynx, supraglottis, and hypopharynx. Surgical biopsy showed chronically inflamed granulation tissue without malignancy, necrosis, or vasculitis. All stains were negative for any organisms...
January 27, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28133243/-a-case-of-thyroid-carcinoma-in-consideration-for-perioperative-management
#17
Katsuhisa Enomoto, Kenichi Sakurai
When patients are on long-term dialysis, various kinds of medication are given. We report our experience with a 75-yearold woman with thyroid carcinoma incidentally discovered during dialysis. Ultrasonography of the thyroid showed a tumor of about 3 cm in the right lobe center. The dialysis performed surgery on the day when we were not dialyzed. Heparinization for anticoagulation was not administered. Adhesion with the circumferential organ was strong, and in the perioperative findings, the thyroid gland showed difficulty in sublation...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28123594/histone-deacetylase-inhibitor-saha-as-potential-targeted-therapy-agent-for-larynx-cancer-cells
#18
Aneta Grabarska, Jarogniew J Łuszczki, Ewa Nowosadzka, Ewelina Gumbarewicz, Witold Jeleniewicz, Magdalena Dmoszyńska-Graniczka, Krystyna Kowalczuk, Krzysztof Kupisz, Krzysztof Polberg, Andrzej Stepulak
Objective: Laryngeal squamous cell carcinoma is one of the most common malignant tumors in the head and neck region. Due to the poor response to chemotherapeutics in patients and low survival rate, successful treatment of larynx cancer still remains a challenge. Therefore, the identification of novel treatment options is needed. We investigated the anticancer effects of suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor, on two different laryngeal cancer cell lines RK33 and RK45. We also studied the antiproliferative action of SAHA in combination with cisplatin and defined the type of pharmacological interaction between these drugs...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28121481/robotic-thymectomy-learning-curve-and-associated-perioperative-outcomes
#19
Mohamed K Kamel, Mohamed Rahouma, Brendon M Stiles, Abu Nasar, Nasser K Altorki, Jeffrey L Port
INTRODUCTION: Recently, robotic-assisted thymectomy (RAT) has emerged as an alternative to either, an open transsternal approach or to a video-assisted thoracoscopic approach, for both thymic tumors and benign lesions. We have reviewed our early experience with RAT to assess the associated learning curve as well as the short-term perioperative outcomes. METHODS: A prospectively collected database was reviewed for patients who underwent RAT for all causes in the period 2012-2016...
January 25, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28116994/expression-of-lysyl-oxidase-predictive-of-distant-metastasis-of-laryngeal-cancer
#20
Yoon Se Lee, Yangsoon Park, Minsu Kwon, Jong-Lyel Roh, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim
Objective To investigate the prognostic significance of lysyl oxidase (LOX) expression in laryngeal cancer. Study Design Retrospective chart review and histologic analysis. Setting Tertiary referral academic center. Subjects and Methods Patients (N = 100) underwent surgical treatment for laryngeal cancer and had tissue specimens available. Immunohistochemical staining for LOX was performed on laryngeal cancer tissue microarrays, and the proportion and intensity of staining were evaluated. Patients with LOX scores ≤6 were classified into the low LOX group, while those with scores >6 were classified into the high LOX group...
January 1, 2017: Otolaryngology—Head and Neck Surgery
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