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https://www.readbyqxmd.com/read/28345455/recurrent-epigenetic-silencing-of-the-ptprd-tumor-suppressor-in-laryngeal-squamous-cell-carcinoma
#1
Marcin Szaumkessel, Sonia Wojciechowska, Joanna Janiszewska, Natalia Zemke, Ewa Byzia, Katarzyna Kiwerska, Magdalena Kostrzewska-Poczekaj, Adam Ustaszewski, Malgorzata Jarmuz-Szymczak, Reidar Grenman, Malgorzata Wierzbicka, Anna Bartochowska, Krzysztof Szyfter, Maciej Giefing
Cellular processes like differentiation, mitotic cycle, and cell growth are regulated by tyrosine kinases with known oncogenic potential and tyrosine phosphatases that downmodulate the first. Therefore, tyrosine phosphatases are recurrent targets of gene alterations in human carcinomas. We and others suggested recently a tumor suppressor function of the PTPRD tyrosine phosphatase and reported homozygous deletions of the PTPRD locus in laryngeal squamous cell carcinoma. In this study, we investigated other gene-inactivating mechanisms potentially targeting PTPRD, including loss-of-function mutations and also epigenetic alterations like promoter DNA hypermethylation...
March 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28341337/anti-inflammatory-effects-of-hyperbaric-oxygen-on-irradiated-laryngeal-tissues
#2
Mitat Arıcıgil, Mehmet Akif Dündar, Abitter Yücel, Hamdi Arbağ, Abdullah Arslan, Meryem Aktan, Sıdıka Fındık, İbrahim Kılınç
INTRODUCTION: To manage the complications of irradiation of head and neck tissue is a challenging issue for the otolaryngologist. Definitive treatment of these complications is still controversial. Recently, hyperbaric oxygen therapy is promising option for these complications. OBJECTIVE: In this study, we used biochemical and histopathological methods to investigate the efficacy of hyperbaric oxygen against the inflammatory effects of radiotherapy in blood and laryngeal tissues when radiotherapy and hyperbaric oxygen are administered on the same day...
February 27, 2017: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28338500/differential-diagnosis-in-neuroendocrine-neoplasms-of-the-larynx
#3
Jennifer L Hunt, Alfio Ferlito, Henrik Hellquist, Alessandra Rinaldo, Alena Skálová, Pieter J Slootweg, Stefan M Willems, Antonio Cardesa
The differential diagnosis of neuroendocrine neoplasms of the larynx is broad and includes lesions of epithelial, mesenchymal, and neuroectodermal origin. These lesions have overlapping clinical and pathologic aspects and must be carefully considered in the differential diagnosis of laryngeal neoplasms. The prognosis and treatment are also different among these tumor types, which necessitates making these distinctions clinically. The current literature was reviewed to provide updated information regarding the epithelial-derived tumors, including carcinoid, atypical carcinoid, small cell neuroendocrine carcinomas, large cell neuroendocrine carcinoma, and squamous cell carcinoma with neuroendocrine component...
March 23, 2017: Advances in Anatomic Pathology
https://www.readbyqxmd.com/read/28327951/hpv16-dna-and-integration-in-normal-and-malignant-epithelium-implications-for-the-etiology-of-laryngeal-squamous-cell-carcinoma
#4
X Chen, L Gao, E M Sturgis, Z Liang, Y Zhu, X Xia, X Zhu, X Chen, G Li, Z Gao
Background: Molecular evidence suggests that human papillomavirus (HPV) has a role in the etiology of oropharyngeal squamous cell carcinoma. However, the role of HPV in laryngeal squamous cell carcinoma (LSCC) is unclear. Patients and Methods: We conducted a case-control study using tumor tissue specimens from 300 LSCC patients and vocal cord polyp specimens from 300 cancer-free controls. HPV genotype, HPV16 viral load and viral integration status, and p16 expression were determined...
January 23, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28316781/dyspnea-and-dysphagia-associated-to-hypopharyngeal-fibrolipoma-a-case-report
#5
Marco A Mendez Saenz, Vicente J Villagomez Ortiz, Mario Jesús Jr Villegas González, Baltazar Gonzalez Andrade, Miguel Angel Liñan Arce, German A Soto-Galindo, José Luis Treviño González
Fibrolipomas are benign lesions conformed by fat and connective tissue, classified as histologic variants of lipomas. They are rarely located in the head and neck and represent less than 0.6% of the benign tumors of the larynx and hypopharynx. Their clinical presentation depends on its location and size. We present the case of a 51-year-old male patient who reported progressive dyspnea, dysphagia and obstructive sleep symptoms with a duration of 3 months, without apparent cause. A pharyngolaryngeal fiberoptic endoscopy showed a smooth, rounded mass in the posterior wall of the hypopharynx, partially obstructing the laryngeal vestibule, creating a valve effect...
April 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/28304089/phosphorylated-fadd-is-not-prognostic-for-local-control-in-t1-t2-supraglottic-laryngeal-carcinoma-treated-with-radiotherapy
#6
Jan E Wachters, Michiel L Schrijvers, Lorian Slagter-Menkema, Mirjam Mastik, Johannes A Langendijk, Geertruida H de Bock, Jan L Roodenburg, Bernard F A M van der Laan, Jacqueline E van der Wal, Ed Schuuring
OBJECTIVE: The Fas-Associated Death Domain (FADD) gene is located in the chromosome 11q13-region and frequently is amplified in head and neck squamous cell carcinoma. Expression of FADD and its phosphorylated isoform (pFADD) have been associated with aggressive tumor growth, lymph node metastasis, and overall survival. Previously, we demonstrated that pFADD expression was related to a significantly improved local control in early stage (tumor [T]1 to T2) glottic laryngeal squamous cell carcinoma (LSCC)...
March 17, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28297754/-clinicopathologic-characteristics-of-head-and-neck-carcinoma-showing-thymus-like-element
#7
X J Cui, C Y Zhang, P Su, B Lyu, Y B Ren, X S Fan, X F Zhang, Y Wang, Y H Song, Z Y Liu
Objective: To investigate clinicopathological features of carcinoma showing thymus-like elements (CASTLE) in the head and neck regions. Methods: Clinicopathological data of 7 patients with CASTLE in the head and neck regions were retrospectively reviewed.Immunohistochemical staining and in situ hybridization for EBER were performed. BRAF(V600E) mutation was examined by ARMS method in 6 cases. Results: There were 5 females and 2 males with age between 49 and 78 years (average of 65.6 years). All tumors were solitary nodular lesions with an infiltrative border, including 6 intrathyroid tumors and 1 extrathyroid tumor in the laryngeal pharynx...
March 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/28296244/-watchful-observation-follow-up-scheme-after-endoscopic-co2-laser-treatment-for-small-glottic-carcinomas-a-retrospective-study-of-93-cases
#8
Patrice Gallet, Cécile Rumeau, Duc Trung Nguyen, Pedro Augusto Teixeira, Cédric Baumann, Bruno Toussaint
OBJECTIVES: Evaluate the clinical outcome of patients treated with CO2-laser surgery for early-stage glottic carcinomas followed-up with 3 month laryngoscopy regardless of tumor grade and margins. DESIGN: Case series. SETTING: Retrospective review of the clinical records of patients treated at the ENT department of a tertiary university hospital. PARTICIPANTS AND METHOD: Clinical records from patients with early-stage glottic carcinomas (Tis-T2) treated with curative intent by CO2-laser surgery in a ten year period were evaluated...
March 10, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28295829/chondroradionecrosis-of-the-larynx-24-year-university-of-wisconsin-experience
#9
Thomas G Gessert, Christopher J Britt, Austin M W Maas, Aaron M Wieland, Paul M Harari, Gregory K Hartig
BACKGROUND: Chondroradionecrosis (CRN) is an uncommon but significant complication of laryngeal radiotherapy that presents a diagnostic challenge to clinicians through its similarity in presentation to cancer recurrence. METHODS: Two hundred ninety-four patients underwent primary, adjuvant, or salvage radiation for laryngeal cancer from 1991 to 2015 at the University of Wisconsin. Medical records were reviewed to identify and characterize patients with a diagnosis of CRN...
March 11, 2017: Head & Neck
https://www.readbyqxmd.com/read/28291932/online-dosimetric-evaluation-of-larynx-sbrt-a-pilot-study-to-assess-the-necessity-of-adaptive-replanning
#10
Weihua Mao, Timothy Rozario, Weiguo Lu, Xuejun Gu, Yulong Yan, Xun Jia, Baran Sumer, David L Schwartz
PURPOSE: We have initiated a multi-institutional phase I trial of 5-fraction stereotactic body radiotherapy (SBRT) for Stage III-IVa laryngeal cancer. We conducted this pilot dosimetric study to confirm potential utility of online adaptive replanning to preserve treatment quality. METHODS: We evaluated ten cases: five patients enrolled onto the current trial and five patients enrolled onto a separate phase I SBRT trial for early-stage glottic larynx cancer. Baseline SBRT treatment plans were generated per protocol...
January 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28280643/synovial-sarcoma-of-the-larynx-report-of-a-case-and-review-of-literature
#11
Geetha Narayanan, Anto Baby, Thara Somanathan, Sreedevi Konoth
Sarcomas account for less than 1% of malignant neoplasms arising in the head and neck in adults. Laryngeal synovial sarcoma is an extremely rare form of laryngeal malignancy with less than 20 cases reported in the literature. We report the case of a 48-year-old man with synovial sarcoma of the larynx. He underwent excision of the tumor followed by radiation. He is alive in remission at 36 months. The literature on synovial sarcoma of the larynx is reviewed.
2017: Case Reports in Otolaryngology
https://www.readbyqxmd.com/read/28277256/-anesthetic-considerations-for-awake-craniotomy-case-report
#12
Cassiano Hamacek de Freitas, Celso Homero Santos Oliveira, Daniel Câmara de Rezende, Joyce Romano, Henrique Rodrigues Lemos Silva, Ivana Mares Trivellato
BACKGROUND AND OBJECTIVES: The conscious patient cooperation during neurological procedures has become necessary for the delimitation of areas to be managed by a neurosurgeon, with better results in the treatment of tumor lesions, vascular or epileptic foci, and sequelae minimization. The need for perioperative awareness (responsiveness to commands) challenges anesthesiologists to further ensure patient safety during the procedure. Several techniques have been described for this purpose...
October 26, 2016: Revista Brasileira de Anestesiologia
https://www.readbyqxmd.com/read/28272707/reduced-mir-300-expression-predicts-poor-prognosis-in-patients-with-laryngeal-squamous-cell-carcinoma
#13
F-Y He, H-J Liu, Q Guo, J-L Sheng
OBJECTIVE: miR-300 has been demonstrated to play an important role in the progression of several tumors, but its role in tumorigenesis of laryngeal squamous cell carcinoma (LSCC) is still unclear. The purpose of this study was to explore miR-300 expression in LSCC patients and analyze its association with clinicopathological factors and prognosis. PATIENTS AND METHODS: In the present study, we measured the expression level of miR-300 in LSCC tissues by RT-PCR. Associations between miRNA-300 expressions and various clinicopathological characteristics were analyzed...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28269752/a-80-gene-set-potentially-predicts-the-relapse-in-laryngeal-carcinoma-optimized-by-support-vector-machine
#14
Bo Yang, Qing Guo, Fei Wang, Kemin Cai, Xueli Bao, Jiusheng Chu
OBJECTIVE: The present study was performed to identify a gene set for predicting the relapse in laryngeal carcinoma using large data analysis methods. METHODS: Two gene expression profile data of laryngeal carcinoma (GSE27020 and GSE25727) were downloaded from public database. Genes associated with tumor relapse, namely informative genes, were identified by Cox regression analysis. Then the protein-protein interaction (PPI) network consisting of informative genes was constructed...
February 27, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28266802/polydatin-inhibits-cell-proliferation-and-induces-apoptosis-in-laryngeal-cancer-and-hela-cells-via-suppression-of-the-pdgf-akt-signaling-pathway
#15
Haixia Li, Baoyuan Shi, Yanyun Li, Fengfang Yin
Polydatin (PD), a stilbene compound extracted from Polygonum cuspidatum, is suggested to possess anti-cancer activities, including inhibition of cell proliferation, cell cycle arrest, and induction of apoptosis. The platelet-derived growth factor (PDGF)/AKT signaling pathway plays complex roles in tumor suppression. However, the effect of PD on the PDGF/AKT signaling pathway in laryngeal cancer and HeLa cells has not been explored. MTT assay and flow cytometry showed that PD inhibited cell proliferation and induced apoptosis in Hep-2 and AMC-HN-8 cells...
March 7, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/28266295/simultaneous-total-esophagectomy-and-anterior-mediastinal-tracheostomy-for-recurrent-laryngeal-cancer-extended-to-the-superior-mediastinum
#16
Marius Fodor, Marcel Cosgarea, Lucian Fodor
Recurrent laryngeal cancer has an incidence of 25-50% and a 23-35% fiveyear survival rate. Surgery is the best treatment in order to control local recurrence. Herein, we present our surgical strategy for a patient with a history of modified radical laryngectomy for laryngeal cancer and with recurrent tumor at the cervical tracheostomy site extended to the thoracic trachea and esophagus. The wide resection included the sternal manubrium, the upper thoracic trachea, the entire esophagus and the upper mediastinal lymph nodes...
January 2017: Chirurgia
https://www.readbyqxmd.com/read/28259905/matrix-stiffness-regulates-the-proliferation-stemness-and-chemoresistance-of-laryngeal-squamous-cancer-cells
#17
Lian Hui, Jingru Zhang, Xiaoxu Ding, Xing Guo, Xuejun Jiang
Increasing evidence shows that matrix stiffness plays a critical role in affecting the phenotype and behavior of tumor cells. We report that matrix stiffness significantly regulated the proliferation and chemotherapeutic response of Hep-2 cells. Increasing substrate stiffness promotes the proliferation of Hep-2 cells. When cultured on soft gels, Hep-2 cells expressed higher level of stem cell markers. Following treatment with cisplatin or 5-FU, we observed reduced apoptosis in Hep-2 cells cultured on soft supports...
April 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28259450/modality-specific-target-definition-for-laryngeal-and-hypopharyngeal-cancer-on-fdg-pet-ct-and-mri
#18
Hans Ligtenberg, Elise Anne Jager, Joana Caldas-Magalhaes, Tim Schakel, Frank A Pameijer, Nicolien Kasperts, Stefan M Willems, Chris H J Terhaard, Cornelis P J Raaijmakers, Marielle E P Philippens
BACKGROUND AND PURPOSE: The goal of this study was to improve target definition by deriving modality-specific margins for clinical target volumes (CTV) for laryngeal and hypopharyngeal cancer on CT, MRI and 18-FDG-PET. MATERIAL AND METHODS: Twenty-five patients with T3/T4 laryngeal/hypopharyngeal cancer underwent CT, MRI and 18-FDG-PET scans before laryngectomy. HE-sections were obtained from the surgical specimen and tumor was delineated (tumorHE). The GTVs on CT and MRI were delineated in consensus...
March 1, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28252821/transoral-laser-microsurgery-or-total-laryngectomy-for-recurrent-squamous-cell-carcinoma-of-the-larynx-retrospective-analysis-of-199-cases
#19
Bernhard G Weiss, Mattis Bertlich, Martin Canis, Friedrich Ihler
BACKGROUND: Surgical treatment options for local recurrences of laryngeal cancer can be either organ-preserving surgery or total laryngectomy. The purpose of this study was to present our evaluation of the treatment with transoral laser microsurgery (TLM) in comparison to laryngectomy. METHODS: We conducted a retrospective review of 199 consecutive patients with recurrent laryngeal cancer at 1 tertiary referral center. RESULTS: The 5-year overall survival, disease-specific survival, and local control rates were 64...
March 2, 2017: Head & Neck
https://www.readbyqxmd.com/read/28251322/circulating-calprotectin-as-a-biomarker-of-laryngeal-carcinoma
#20
Muhammet Fatih Topuz, Adem Binnetoglu, Ali Cemal Yumusakhuylu, Murat Sarı, Tekin Baglam, Fetullah Gerin
Calprotectin is an S100 protein and marker of inflammation found in neutrophils and monocytes; S100 proteins are a family of calcium-modulated proteins. The aim of this study was to determine if the serum concentration of calprotectin is higher in patients with laryngeal carcinoma than in patients with benign laryngeal pathologies and controls. The study included 107 participants. The serum calprotectin concentration was analyzed using the calprotectin ELISA (enzyme-linked immunosorbent assay) kit (Calpo AS, Norway)...
March 1, 2017: European Archives of Oto-rhino-laryngology
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