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MiR-1915

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https://www.readbyqxmd.com/read/27852979/expansion-induced-microrna-changes-in-bone-marrow-mesenchymal-stromal-cells-reveals-interplay-between-immune-regulation-and-cell-cycle
#1
Lotta Kilpinen, Amarjit Parmar, Dario Greco, Matti Korhonen, Petri Lehenkari, Päivi Saavalainen, Saara Laitinen
Mesenchymal stromal cells (MSC) are currently used in many cell based therapies. Prior to use in therapy, extensive expansion is required. We used microarray profiling to investigate expansion induced miRNA and mRNA expression changes of bone marrow MSCs (BM-MSCs) derived from old and young donors. The expression levels of 36 miRNAs were altered in cells derived from the old and respectively 39 miRNAs were altered in cells derived from young donors. Of these, only 12 were differentially expressed in both young and old donor BM-MSCs, and their predicted target mRNAs, were mainly linked to cell proliferation and senescence...
November 9, 2016: Aging
https://www.readbyqxmd.com/read/27586203/mirna-expression-profiling-of-noninvasive-follicular-thyroid-neoplasms-with-papillary-like-nuclear-features-compared-with-adenomas-and-infiltrative-follicular-variants-of-papillary-thyroid-carcinomas
#2
Nicla Borrelli, Maria Denaro, Clara Ugolini, Anello Marcello Poma, Mario Miccoli, Paolo Vitti, Paolo Miccoli, Fulvio Basolo
Follicular variants of papillary thyroid carcinoma include encapsulated (with or without capsular/vascular invasion) and infiltrative forms, which have different clinical behaviors. The encapsulated forms that lack capsular invasion have an indolent clinical behavior that is similar to benign lesions; therefore, they were recently reclassified as 'noninvasive follicular thyroid neoplasms with papillary-like nuclear features' (NIFTPs). Because NIFTPs have nuclear features of papillary carcinomas, distinguishing between NIFTPs and infiltrative follicular variant of papillary thyroid carcinoma is almost impossible with cytological examination...
September 2, 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/27144561/ewing-s-sarcoma-an-analysis-of-mirna-expression-profiles-and-target-genes-in-paraffin-embedded-primary-tumor-tissue
#3
Antonina Parafioriti, Caterina Bason, Elisabetta Armiraglio, Lucia Calciano, Primo Andrea Daolio, Martina Berardocco, Andrea Di Bernardo, Alessia Colosimo, Roberto Luksch, Anna C Berardi
The molecular mechanism responsible for Ewing's Sarcoma (ES) remains largely unknown. MicroRNAs (miRNAs), a class of small non-coding RNAs able to regulate gene expression, are deregulated in tumors and may serve as a tool for diagnosis and prediction. However, the status of miRNAs in ES has not yet been thoroughly investigated. This study compared global miRNAs expression in paraffin-embedded tumor tissue samples from 20 ES patients, affected by primary untreated tumors, with miRNAs expressed in normal human mesenchymal stromal cells (MSCs) by microarray analysis...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/26930277/urinary-exosomal-mirna-signature-in-type-ii-diabetic-nephropathy-patients
#4
Denis Delić, Claudia Eisele, Ramona Schmid, Patrick Baum, Franziska Wiech, Martin Gerl, Heike Zimdahl, Steven S Pullen, Richard Urquhart
MicroRNAs (miRNAs) are short non-coding RNA species which are important post-transcriptional regulators of gene expression and play an important role in the pathogenesis of diabetic nephropathy. miRNAs are present in urine in a remarkably stable form packaged in extracellular vesicles, predominantly exosomes. In the present study, urinary exosomal miRNA profiling was conducted in urinary exosomes obtained from 8 healthy controls (C), 8 patients with type II diabetes (T2D) and 8 patients with type II diabetic nephropathy (DN) using Agilent´s miRNA microarrays...
2016: PloS One
https://www.readbyqxmd.com/read/25955157/correction-mir-1915-and-mir-1225-5p-regulate-the-expression-of-cd133-pax2-and-tlr2-in-adult-renal-progenitor-cells
#5
Fabio Sallustio, Grazia Serino, Vincenzo Costantino, Claudia Curci, Sharon N Cox, Giuseppe De Palma, Francesco P Schena
No abstract text is available yet for this article.
2015: PloS One
https://www.readbyqxmd.com/read/25682967/circulating-and-urinary-microrna-profile-in-focal-segmental-glomerulosclerosis-a-pilot-study
#6
COMPARATIVE STUDY
Ali Ramezani, Joseph M Devaney, Scott Cohen, Maria R Wing, Richard Scott, Susan Knoblach, Rishi Singhal, Lilian Howard, Jeffrey B Kopp, Dominic S Raj
BACKGROUND: MicroRNAs (miRNAs) are noncoding RNA molecules that play important roles in the pathogenesis of various kidney diseases. We investigated whether patients with minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS) have distinct circulating and urinary miRNA expression profiles that could lead to potential development of noninvasive biomarkers of the disease. MATERIALS AND METHODS: Exosome miRNAs were extracted from plasma and urine samples of patients with primary FSGS (n = 16) or MCD (n = 5) and healthy controls (n = 5)...
April 2015: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/25682061/differential-expression-profiling-of-circulation-micrornas-in-ptc-patients-with-non-131i-and-131i-avid-lungs-metastases-a-pilot-study
#7
Zhong-Ling Qiu, Chen-Tian Shen, Hong-Jun Song, Wei-Jun Wei, Quan-Yong Luo
INTRODUCTION: Loss of the ability to concentrate (131)I is one of the important causes of radioiodine-refractory disease in papillary thyroid carcinoma (PTC). Recent advantages of serum microRNAs (miRNAs) open a new realm of possibilities for noninvasive diagnosis and prognosis of many cancers. The aim of the current study was to identify differential expression profiling of circulation miRNAs in PTC patients with non-(131)I and (131)I-avid lungs metastases. METHODS: The expressions of miRNAs were examined using miRNA microarray chip...
May 2015: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/24886442/role-of-non-coding-rnas-in-maintaining-primary-airway-smooth-muscle-cells
#8
Mark M Perry, Eleni Tsitsiou, Philip J Austin, Mark A Lindsay, David S Gibeon, Ian M Adcock, Kian Fan Chung
BACKGROUND: The airway smooth muscle (ASM) cell maintains its own proliferative rate and contributes to the inflammatory response in the airways, effects that are inhibited by corticosteroids, used in the treatment of airways diseases. OBJECTIVE: We determined the differential expression of mRNAs, microRNAs (miRNAs) and long noncoding RNA species (lncRNAs) in primary ASM cells following treatment with a corticosteroid, dexamethasone, and fetal calf serum (FCS). METHODS: mRNA, miRNA and lncRNA expression was measured by microarray and quantitative real-time PCR...
2014: Respiratory Research
https://www.readbyqxmd.com/read/24814047/tumor-suppressor-p53-induces-mir-1915-processing-to-inhibit-bcl-2-in-the-apoptotic-response-to-dna-damage
#9
Kazuya Nakazawa, Nurmaa Dashzeveg, Kiyotsugu Yoshida
The antiapoptotic protein Bcl-2 is overexpressed in human cancers, and confers resistance to antitumor agents in cancer cells. Bcl-2 is negatively regulated by the tumor suppressor p53 in response to DNA damage during apoptotic cell death. However, this molecular mechanism remains unclear. The available evidence indicates that miR-1915 represses Bcl-2 expression at the post-transcriptional level in human colorectal carcinoma cells, which is correlated with drug resistance. Here, we show that p53 controls miR-1915 expression in response to DNA damage...
July 2014: FEBS Journal
https://www.readbyqxmd.com/read/23861881/mir-1915-and-mir-1225-5p-regulate-the-expression-of-cd133-pax2-and-tlr2-in-adult-renal-progenitor-cells
#10
Fabio Sallustio, Grazia Serino, Vincenzo Costantino, Claudia Curci, Sharon N Cox, Giuseppe De Palma, Francesco P Schena
Adult renal progenitor cells (ARPCs) were recently identified in the cortex of the renal parenchyma and it was demonstrated that they were positive for PAX2, CD133, CD24 and exhibited multipotent differentiation ability. Recent studies on stem cells indicated that microRNAs (miRNAs), a class of noncoding small RNAs that participate in the regulation of gene expression, may play a key role in stem cell self-renewal and differentiation. Distinct sets of miRNAs are specifically expressed in pluripotent stem cells but not in adult tissues, suggesting a role for miRNAs in stem cell self-renewal...
2013: PloS One
https://www.readbyqxmd.com/read/23255549/refining-diagnostic-microrna-signatures-by-whole-mirnome-kinetic-analysis-in-acute-myocardial-infarction
#11
Britta Vogel, Andreas Keller, Karen S Frese, Wanda Kloos, Elham Kayvanpour, Farbod Sedaghat-Hamedani, Sarah Hassel, Sabine Marquart, Markus Beier, Evangelos Giannitis, Stefan Hardt, Hugo A Katus, Benjamin Meder
BACKGROUND: Alterations in microRNA (miRNA) expression patterns in whole blood may be useful biomarkers of diverse cardiovascular disorders. We previously reported that miRNAs are significantly dysregulated in acute myocardial infarction (AMI) and applied machine-learning techniques to define miRNA subsets with high diagnostic power for AMI diagnosis. However, the kinetics of the time-dependent sensitivity of these novel miRNA biomarkers remained unknown. METHODS: To characterize temporal changes in the expressed human miRNAs (miRNome), we performed here the first whole-genome miRNA kinetic study in AMI patients...
February 2013: Clinical Chemistry
https://www.readbyqxmd.com/read/22121083/mir-1915-inhibits-bcl-2-to-modulate-multidrug-resistance-by-increasing-drug-sensitivity-in-human-colorectal-carcinoma-cells
#12
Ke Xu, Xin Liang, Daling Cui, Yixin Wu, Weibin Shi, Jianwen Liu
Colorectal carcinoma is a frequent cause of cancer-related death in the world for men and women. microRNAs are endogenous small noncoding RNAs that regulate gene expression negatively at post-transcriptional level. Here, we investigated the possible role of microRNAs in the development of multidrug resistance (MDR) in colorectal carcinoma cells. We analyzed microRNA (miRNA) expression levels between multidrug resistant colorectal carcinoma cell line HCT116/L-OHP and its parent cell line HCT116 using a miRNA microarray...
January 2013: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/21042738/short-gc-rich-rna-similar-to-mir-1909-and-1915-folds-in-silico-with-the-5-utr-and-orf-of-notch-and-responders-potential-for-the-elimination-of-cancer-stem-cells
#13
Yufeng Li, Takashi Mine, Constantin G Ioannides
Novel therapeutic approaches to eliminate cancer stem cells (CSCs) are being developed. This development is imperative as CSCs are resistant to drugs; they divide activated by ligands on the epithelium or on neighboring cancer cells. Specific commands for division originate from Notch-1 ligands. Notch-1 cleavage inhibitors can have opposite effects from the ones expected when the levels of Notch ligands are high on neighboring cancer cells. High levels of Jagged-1 are a common feature of ovarian tumors. Some gene pathways enhance, others repress transcription of Notch-1, while Notch-1 itself activates Myc and HIF-1α...
December 2010: Oncology Reports
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