Chihiro Kiyoshima, Naoto Shirasu, Daichi Urushiyama, Satoshi Fukagawa, Toyofumi Hirakawa, Kenichi Yoshikawa, Daisuke Izuchi, Kohei Miyata, Masamitsu Kurakazu, Fusanori Yotsumoto, Kenji Hiromatsu, Makoto Nomiyama, Ohta Eiji, Shinichi Hirose, Yoshitoshi Ogura, Tetsuya Hayashi, Kenichiro Hata, Kazuki Nabeshima, Shin'ichiro Yasunaga, Shingo Miyamoto
BACKGROUND: This study was performed to investigate the clinical significance of miR-4535 and miR-1915-5p in severe chorioamnionitis. MATERIALS & METHODS: Amniotic fluid samples from 37 patients with severe chorioamnionitis were subjected to miRNA array analysis and ddPCR™. Diagnostic values were assessed using the receiver operating characteristic curve. The patients were separated into three groups according to Blanc's criteria. RESULTS: The expression of miR-4535 and miR-1915-5p was significantly correlated with the copy number of 16S rDNA, had extremely high diagnostic accuracy for severe chorioamnionitis, and was linked to maternal and fetal inflammation...
February 15, 2021: Future Science OA