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https://www.readbyqxmd.com/read/29682203/mutation-analysis-of-the-egfr-pathway-genes-egfr-ras-pik3ca-braf-and-akt1-in-salivary-gland-adenoid-cystic-carcinoma
#1
Kosuke Saida, Takayuki Murase, Mayuko Ito, Kana Fujii, Hisashi Takino, Ayako Masaki, Daisuke Kawakita, Kei Ijichi, Yuichiro Tada, Kimihide Kusafuka, Yoshiyuki Iida, Tetsuro Onitsuka, Yasushi Yatabe, Nobuhiro Hanai, Yasuhisa Hasegawa, Hitomi Shinomiya, Ken-Ichi Nibu, Kazuo Shimozato, Hiroshi Inagaki
Adenoid cystic carcinoma (AdCC), one of the most common salivary gland carcinomas, usually has a fatal outcome. Epidermal growth factor receptor (EGFR) pathway gene mutations are important in predicting a patient's prognosis and estimating the efficacy of molecular therapy targeting the EGFR pathway. In this study of salivary gland AdCC (SAdCC), we looked for gene mutations in EGFR, RAS family ( KRAS, HRAS, and NRAS ), PIK3CA, BRAF, and AKT1 , using a highly sensitive single-base extension multiplex assay, SNaPshot...
March 30, 2018: Oncotarget
https://www.readbyqxmd.com/read/29678584/genome-wide-profiles-of-metastasis-associated-mrnas-and-micrornas-in-salivary-adenoid-cystic-carcinoma
#2
Shubin Wang, Lei Zhang, Pengwei Shi, Yuanyuan Zhang, Hong Zhou, Xuanping Cao
Salivary adenoid cystic carcinoma (SACC) is often accompanied with poor prognosis due to local recurrence, distant metastasis, and perineural invasion. The mechanism involved in SACC metastasis is not yet fully understood. In this study, we profiled the expression of messenger RNA (mRNA) and microRNA (miRNA) in an SACC cell line, ACC-2, and a highly metastatic SACC cell line, ACC-M, using high-throughput sequencing. We discovered that: (1) differentially expressed (DE) mRNAs and DE miRNAs are potentially involved in SACC metastasis; (2) multiple regulatory interactions between DE miRNAs and DE mRNAs exist; and (3) miR-338-5p/3p target LAMC2 to impair motility and invasion of ACC-M and MDA-MB-231 cells...
April 17, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29675107/reassessing-the-potential-of-myb-targeted-anti-cancer-therapy
#3
REVIEW
Xiaofeng Liu, Yunxiao Xu, Liping Han, Yan Yi
Transcription factor MYB is essential for the tumorigenesis of multiple cancers, especially leukemia, breast cancer, colon cancer, adenoid cystic carcinoma and brain cancer. Thus, MYB has been regarded as an attractive target for tumor therapy. However, pioneer studies of antisense oligodeoxynucleotides against MYB, which were launched three decades ago in leukemia therapy, were discontinued because of their unsatisfactory clinical outcomes. In recent years, the roles of MYB in tumor transformation have become increasingly clear...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29671211/characterisation-of-dog-1-expression-in-salivary-gland-tumours-and-comparison-with-myoepithelial-markers
#4
Syed A Khurram, Paul M Speight
DOG1 is an established diagnostic marker for gastrointestinal stromal tumours (GIST), but has been reported in salivary gland tumours (SGT) as an acinar and intercalated duct marker. However, its specificity and distribution is not well established. The aim of this study was to evaluate the diagnostic utility of DOG-1 expression in SGT in addition to comparing it with myoepithelial markers. Normal salivary tissue and SGT (n = 184) were examined for expression of DOG1 and a range of myoepithelial markers...
April 18, 2018: Head and Neck Pathology
https://www.readbyqxmd.com/read/29669190/analysis-of-histologic-follow-up-and-risk-of-malignancy-for-salivary-gland-neoplasm-of-uncertain-malignant-potential-proposed-by-the-milan-system-for-reporting-salivary-gland-cytopathology
#5
Haiyan Liu, Clarissa Ljungren, Fan Lin, Matthew A Zarka, Longwen Chen
BACKGROUND: The Milan System for Reporting Salivary Gland Cytopathology is a tiered classification scheme that includes 6 diagnostic categories. Neoplasm, which is 1 of the 6 proposed categories, consists of benign neoplasm and neoplasm of uncertain malignant potential (NUMP). NUMP is reserved for a salivary gland neoplasm without clear distinction between benign and malignant. The objective of this study was to assess the risk of malignancy (ROM) of NUMP. METHODS: A retrospective analysis was conducted on 656 salivary gland fine-needle aspiration specimens from 2010 to 2016...
April 18, 2018: Cancer Cytopathology
https://www.readbyqxmd.com/read/29665790/the-oncogenic-effects-of-hes1-on-salivary-adenoid-cystic-carcinoma-cell-growth-and-metastasis
#6
Xiao-Yu Huang, Rui-Huan Gan, Jian Xie, Lin She, Yong Zhao, Lin-Can Ding, Bo-Hua Su, Da-Li Zheng, You-Guang Lu
BACKGROUND: Our previous study demonstrated a close relationship between NOTCH signaling pathway and salivary adenoid cystic carcinoma (SACC). HES1 is a well-known target gene of NOTCH signaling pathway. The purpose of the present study was to further explore the molecular mechanism of HES1 in SACC. METHODS: Comparative transcriptome analyses by RNA-Sequencing (RNA-Seq) were employed to reveal NOTCH1 downstream gene in SACC cells. Immunohistochemical staining was used to detect the expression of HES1 in clinical samples...
April 17, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29656683/clinicopathologic-analysis-of-2736-salivary-gland-cases-over-a-11-year-period-in-southwest-china
#7
S Y Shen, W H Wang, R Liang, G Q Pan, Y M Qian
OBJECTIVE: To investigate the epidemiological and clinicopathological characteristics of salivary gland tumors in southwest China in order to provide data for clinical diagnosis and other similar research. METHODS: Between March 2007 and December 2017, 2736 patients with salivary gland tumors were recruited, the clinical and pathological data were retrospectively analyzed. RESULTS: A total of 2736 patients had a ratio of males to females of about 1...
April 14, 2018: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29649882/local-atopy-in-childhood-adenotonsillar-hypertrophy
#8
Kyu-Sup Cho, Seong Heon Kim, Sung-Lyong Hong, Jaeyoung Lee, Sue Jean Mun, Young Eun Roh, Young Mi Kim, Hye-Young Kim
Background Although the cause of adenotonsillar hypertrophy remains unknown, some studies have shown that allergy may be a risk factor. Purpose This study determined the levels of allergen-specific immunoglobulin E (sIgE) in the adenotonsillar tissues of children with adenotonsillar hypertrophy and evaluated the clinical significance of local atopy in adenotonsillar tissues. Methods We measured 21 types of specific immunoglobulin E in the serum and adenotonsillar tissues of 102 children with adenotonsillar hypertrophy and compared the sensitization patterns of the serum and local tissues...
January 1, 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29643544/-bronchial-adenoid-cystic-carcinoma-masquerading-as-bronchial-asthma-a-case-report
#9
M Lu, M Wang, X Zhu, Y H Chen, W Z Yao
Here we reported a case of bronchial adenoid cystic carcinoma from Peking University Third Hospital. A 40-year-old female presented with dry cough for 1 year and nocturnal paroxysmal attacks of wheezing for 4 months. She was a non-smoker, and did not have past histories of asthma or allergy. On physical examination, no stridor, wheezing and cyanosis were present and the general appearance was good. The results of the laboratory analysis, including blood eosinophils count, immunoglobulin E level and chest X-ray were normal...
April 18, 2018: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29629953/utility-of-ber-ep4-and-moc-31-in-basaloid-skin-tumor-detection
#10
Pavandeep Gill, Christopher Naugler, Marie S Abi Daoud
Ber-EP4 has been the traditional immunostain used for the detection of basaloid skin tumors. Recently, MOC-31 has shown be superior to Ber-EP4 in the detection of basosquamous basal cell carcinoma (BCC) and many centers are now using both Ber-EP4 and MOC-31 antibodies together to detect these lesions. The objective of this study was to compare the utility of using both Ber-EP4 and MOC-31 immunostains in the detection of basaloid skin tumors and to better characterize the previously unknown staining properties of MOC-31 in cutaneous lesions...
April 7, 2018: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/29627048/pathology-of-primary-tracheobronchial-malignancies-other-than-adenoid-cystic-carcinomas
#11
REVIEW
Darroch Moores, Paresh Mane
Most primary tracheal tumors are malignant. Malignancy of larynx and bronchi are much more likely than trachea. Tracheal tumors are most likely due to direct extension for surrounding tumors. Squamous cell carcinoma and adenoid cystic carcinoma make up about two-thirds of adult primary tracheal tumors. Because of their predominantly local growth pattern, malignant salivary gland-type tumors show a better outcome than other histologic types.
May 2018: Thoracic Surgery Clinics
https://www.readbyqxmd.com/read/29627047/biology-of-adenoid-cystic-carcinoma-of-the-tracheobronchial-tree-and-principles-of-management
#12
REVIEW
Donna E Maziak
Adenoid cystic carcinoma of the trachea is a rare tumor. The mainstay of treatment remains surgical resection, even in the presence of positive margins or metastatic disease. Perineural involvement commonly causes positive margins and should not deter from resection. Knowledge of releasing maneuvers is essential for surgical success. Long-term follow-up is required with patients presenting late and surviving with recurrent disease for years.
May 2018: Thoracic Surgery Clinics
https://www.readbyqxmd.com/read/29624714/two-cases-of-discrete-adenoid-pseudogland-formation-within-benign-intradermal-melanocytic-nevi
#13
Jonathan C Banta, Justin P Bandino
We report two cases of benign intradermal melanocytic nevi with discrete glandular elements and mucin deposition engendering a diagnostic dilemma. The preliminary differential included entrapment of adnexal structures, collision with an adnexal neoplasm such as adenoid cystic carcinoma, or metastatic adenocarcinoma. A colloidal iron special stain confirmed the deposition of mucin, however a pankeratin AE1/AE3 immunohistochemical cocktail was surprisingly negative. Closer cytological examination of the discrete "glands" combined with nearby pseudoangiomatous (almost Kaposiform) change hinted at melanocytic origin, and was confirmed with a positive MART-1 immunohistochemical stain...
April 6, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29622120/imaging-of-minor-salivary-glands
#14
REVIEW
Ahmed Abdel Khalek Abdel Razek, Suresh K Mukherji
Neoplastic and non-neoplastic lesions may involve the minor salivary glands. Tumors of minor salivary glands are commonly seen in the oral cavity. Malignant tumors are more common than benign minor salivary gland tumors. The most common malignant tumors are adenoid cystic carcinoma and mucoepidermoid carcinoma, and the most common benign tumor is pleomorphic adenoma. Non-neoplastic lesions may involve minor salivary glands such as Sjogrene disease, immunoglobulin G4-related disease, necrotizing sialometaplasia, and subacute necrotizing sialadenitis...
May 2018: Neuroimaging Clinics of North America
https://www.readbyqxmd.com/read/29619555/prognostic-significance-of-1p36-locus-deletion-in-adenoid-cystic-carcinoma-of-the-salivary-glands
#15
Petr Šteiner, Simon Andreasen, Petr Grossmann, Lukáš Hauer, Tomáš Vaněček, Markéta Miesbauerová, Thalita Santana, Katalin Kiss, David Slouka, Alena Skálová
Adenoid cystic carcinoma (AdCC) of the salivary glands is characterized by MYB-NFIB or MYBL1-NFIB fusion, prolonged but relentlessly progressive clinical course with frequent recurrences, and development of distant metastasis resulting in high long-term mortality. Currently, no effective therapy is available for patients with advanced non-resectable and/or metastatic disease. Complicating the clinical management of this patient group is the lack of prognostic markers. The purpose of this study is to investigate the prognostic value of 1p36 loss in patients with AdCC...
April 4, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29618938/bimodality-treatment-of-patients-with-pelvic-adenoid-cystic-carcinoma-with-photon-intensity-modulated-radiotherapy-plus-carbon-ion-boost-a-case-series
#16
Denise Bernhardt, Florian Sterzing, Sebastian Adeberg, Klaus Herfarth, Sonja Katayama, Robert Foerster, Juliane Hoerner-Rieber, Laila König, Juergen Debus, Stefan Rieken
Background: Treatment of patients with pelvic adenoid cystic carcinoma (ACC) remains a challenge owing to the rarity of the disease, the lack of data, and the relative radioresistance of these tumors. Case reports: This case series presents the results of three patients with recurrent or inoperable pelvic ACC treated with intensity-modulated radiotherapy (IMRT) plus carbon ion (C12) boost. Patients received C12 therapy at a dose of 3 Gray equivalents (GyE) (relative biological effectiveness [RBE]) per fraction up to 24 GyE RBE, followed by 50 GyE of photon IMRT in 25 fractions...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29617171/lenvatinib-induced-renal-failure-two-first-time-case-reports-and-review-of-literature
#17
Stefano Cavalieri, Laura Cosmai, Augusto Genderini, Manuela Nebuloni, Antonella Tosoni, Federica Favales, Paola Pistillo, Cristiana Bergamini, Paolo Bossi, Lisa Licitra, Laura D Locati, Salvatore Alfieri
Lenvatinib (LEN) is a multi-kinase anti-angiogenic drug recently approved in several cancers. LEN is not easily manageable due to its complex safety profile. Proteinuria and renal failure (RF) were reported among the most frequent LEN-induced adverse events (AEs), often leading to discontinuations or dose modifications. Understanding the pathogenesis of these AEs could ameliorate the management of LEN-induced renal toxicity. Areas covered: We present two cases of LEN-induced renal failure (LIRF) with different pathogenesis...
April 4, 2018: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/29610392/personalized-oncogenomic-analysis-of-metastatic-adenoid-cystic-carcinoma-using-whole-genome-sequencing-to-inform-clinical-decision-making
#18
Manik Chahal, Erin Pleasance, Jasleen Grewal, Eric Zhao, Tony Ng, Erin Chapman, Martin R Jones, Yaoqing Shen, Karen L Mungall, Melika Bonakdar, Gregory A Taylor, Yussanne Ma, Andrew J Mungall, Richard A Moore, Howard Lim, Daniel Renouf, Stephen Yip, Steven J M Jones, Marco A Marra, Janessa Laskin
Metastatic adenoid cystic carcinomas (ACCs) can cause significant morbidity and mortality. Because of their slow growth and relative rarity, there is limited evidence for systemic therapy regimens. Recently, molecular profiling studies have begun to reveal the genetic landscape of these poorly understood cancers, and new treatment possibilities are beginning to emerge. The objective is to use whole-genome and transcriptome sequencing and analysis to better understand the genetic alterations underlying the pathology of metastatic and rare ACCs and determine potentially actionable therapeutic targets...
April 2018: Cold Spring Harbor Molecular Case Studies
https://www.readbyqxmd.com/read/29608903/the-efficacy-of-touch-smear-cytology-in-the-diagnosis-of-salivary-gland-cancers
#19
Seiji Hosokawa, Satoru Takebayashi, Yutaka Sasaki, Hiroyuki Mineta
PURPOSE: Methods for cytologic diagnosis, such as fine-needle aspiration (FNA) and touch smear (TS) cytology, have been frequently used for malignant tumor screening; however, false-negative cases often result in misdiagnosis. The purpose of this study was to investigate the causes of false-negative cases and methods to decrease the false-negative rate in salivary gland tumor TS cytology. MATERIALS AND METHODS: In this cross-sectional study, the authors examined pathologically confirmed salivary gland tumors in 127 cases in which FNA and TS cytology were performed before the operation or open biopsy at Numazu City Hospital (Numazu, Japan) from 2002 to 2016...
March 10, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29607203/3d-printing-aided-resection-of-intratracheal-adenoid-cystic-carcinoma-and-mediastinal-mature-cystic-teratoma-in-a-26-year-old-female-a-case-report
#20
Di Lu, Siyang Feng, Xiguang Liu, Xiaoying Dong, Mei Li, Hua Wu, Pengfei Ren, Dingwei Diao, Kaican Cai
Complete resection remains the ideal treatment for most patients with primary intratracheal tumors. Due to the limit in the resection length, the localization of the tumor during the surgery could be rather difficult if it hasn't invaded out of the trachea, which might be more difficult when there's another tumor in the anterior mediastinum. A 26-year-old woman with intratracheal adenoid cystic carcinoma (ACC) presented with dyspnea. CT scan revealed not only an ACC without extension out of trachea, but also a mediastinal teratoma (MT) near aorta, making the operation much more complicated than usual...
February 2018: Journal of Thoracic Disease
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