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Simon Andreasen
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June 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
Ji-Hyeon Shin, Byung-Guk Kim, Boo Young Kim, Soo Whan Kim, Sung Won Kim, Hojong Kim
BACKGROUND: Low vitamin D levels have been linked to the risk of sleep-disordered breathing (SDB) in children. Although adenotonsillar hypertrophy (ATH) is the major contributor to childhood SDB, the relationship between ATH and serum vitamin D is uncertain. We therefore investigated the relationship between vitamin D levels and associated factors in children with ATH. METHODS: We reviewed data from all children with SDB symptoms who were treated from December 2013 to February 2014...
June 19, 2018: BMC Pediatrics
Y D Huang, J J Tan, X Y Han, F F Zeng, Y F Li, L Wang, X P Li
Objective: To discuss the correlation between adenoid hypertrophy and laryngopharyngeal reflux in children, and to determine the accuracy of reflux symptom index(RSI) and reflux finding score(RFS) in predicting adenoid hypertrophy and laryngopharyngeal reflux(LPR). Method: Assessment of RSI and RFS was performed in 71 children with adenoid hypertrophy who underwent surgery.The adenoid biopsy specimens were examined by pepsin immunohistochemical staining. According to the positive results of pepsin staining to evaluate the sensitivity and specificity of RSI and RFS to predict LPR...
June 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Elaine Tan, Mayur D Mody, Nabil F Saba
Laryngeal cancer (LC) remains a challenging disease to treat. The majority of LCs diagnosed worldwide are squamous cell carcinomas (SCC), and current treatment guidelines are designed to address conventional laryngeal SCC. However, several histologically rare tumor types can originate in the larynx. There is a lack of guidelines regarding the best therapeutic approaches to these tumors and their treatment is often modeled after their recommended management at non-laryngeal sites. Understanding the role for systemic therapy in these rare tumors is important, especially for patients with advanced disease or those who are not surgical candidates...
July 2018: Oral Oncology
Jenny Joselyne Sotelo-Gavito, Mariana Pérez-Montaño, Georgia Alderete-Vázquez, Guadalupe Capetillo-Hernández, Peter Grube-Pagola
Background: The aim of this paper was to know the epidemiological characteristics of the salivary gland tumors in a Mexican population. Methods: A descriptive, retrospective and cross-sectional study was performed. All cases of salivary gland tumor were collected in a period of 5 years (2009-2014) in two hospitals of our State, the Hospital General de Veracruz and the Unidad Médica de Alta Especialidad y Hospital de Especialidades No. 14, with the study of variables like: age, gender, location, biological behavior and histological type...
March 2018: Revista Médica del Instituto Mexicano del Seguro Social
Xiaofeng Yao, Yu Wang, Yuansheng Duan, Qiang Zhang, Ping Li, Rui Jin, Yingjie Tao, Wenchao Zhang, Xudong Wang, Chao Jing, Xuan Zhou
Metastasis is a major cause of poor prognosis in patients suffered with salivary adenoid cystic carcinoma (SACC), in which many factors are implicated. In this study, we identified that IGFBP2, overexpressed in SACC, correlated positively with perineural invasion or metastasis and indicated worse outcome. Moreover, IGFBP2 overexpression could dramatically improve motility and invasion capacity of SACC cells in vitro. Mechanically, IGFBP2 enhanced expression of ZEB1 in a NF-κB (p65)-dependent manner and then promoted epithelial-mesenchymal transition (EMT) in SACC...
June 6, 2018: Cancer Letters
James Jordan Johnston, Richard Douglas
Pathogenic bacteria associated with the adenoids and tonsils cause much morbidity in the paediatric population. Hyperplasia of the adenoids is associated with otitis media with effusion and hyperplasia of the palatine tonsils is associated with both recurrent tonsillitis and obstructive sleep apnoea. Most current knowledge of the microbiology of the upper airways has been derived from culture-based studies, which usually reflect only a small fraction of the bacteria present on the mucosal surface. Culture-independent molecular surveys based on 16S ribosomal RNA sequencing are now being employed to determine the microbiota on the surface and within the tissue of adenoids and palatine tonsils...
June 8, 2018: Postgraduate Medical Journal
Sean G Byars, Stephen C Stearns, Jacobus J Boomsma
Importance: Surgical removal of adenoids and tonsils to treat obstructed breathing or recurrent middle-ear infections remain common pediatric procedures; however, little is known about their long-term health consequences despite the fact that these lymphatic organs play important roles in the development and function of the immune system. Objective: To estimate long-term disease risks associated with adenoidectomy, tonsillectomy, and adenotonsillectomy in childhood...
June 7, 2018: JAMA Otolaryngology—Head & Neck Surgery
Y G Lan, K Chen, Z X Zhang, Y H Ye, Z G Zhang
Objective: To remove the immune function of children with obstructive sleep apnea hypopnea syndrome by resection of adenoids and tonsillar. Method: The fasting peripheral venous blood of children with OSAHS and healthy children were collected. The lymphocyte subsets, NK cells and immunoglobulin levels were compared between the two groups. The fasting blood samples of OSAHS children were collected again after 2d, 30d, 60d and 90d after operation. The changes of lymphocyte subsets, NK cells and immunoglobulin levels were observed after operation...
May 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Muna Kamal, Sukhpreet K Tamana, Lisa Smithson, Linda Ding, Amanda Lau, Joyce Chikuma, Jennifer Mariasine, Diana L Lefebvre, Padmaja Subbarao, Allan B Becker, Stuart E Turvey, Malcolm R Sears, Jacqueline Pei, Piush J Mandhane
OBJECTIVE: Childhood sleep-disordered breathing (SDB) symptoms may comprise multiple phenotypes depending on craniofacial anatomy, tonsil and adenoid growth, body habitus, and rhinitis symptoms. The primary objective of this study is to identify and characterize the different SDB phenotypes to two years of age. METHODS: Data from 770 infants in the Edmonton sub-cohort of the Canadian Healthy Infant Longitudinal Study (CHILD) were analyzed to identify SDB phenotypes based on age of onset and duration of symptoms...
May 3, 2018: Sleep Medicine
Matthew N Mills, George Q Yang, Daniel E Oliver, Casey L Liveringhouse, Kamran A Ahmed, Amber G Orman, Christine Laronga, Susan J Hoover, Nazanin Khakpour, Ricardo L B Costa, Roberto Diaz
BACKGROUND: Triple negative breast cancer (TNBC) is an aggressive disease, but recent studies have identified heterogeneity in patient outcomes. However, the utility of histologic subtyping in TNBC has not yet been well-characterised. This study utilises data from the National Cancer Center Database (NCDB) to complete the largest series to date investigating the prognostic importance of histology within TNBC. METHODS: A total of 729,920 patients (pts) with invasive ductal carcinoma (IDC), metaplastic breast carcinoma (MBC), medullary breast carcinoma (MedBC), adenoid cystic carcinoma (ACC), invasive lobular carcinoma (ILC) or apocrine breast carcinoma (ABC) treated between 2004 and 2012 were identified in the NCDB...
June 2, 2018: European Journal of Cancer
Vivek Kumar, Parita Soni, Mohit Garg, Abhishek Goyal, Trishala Meghal, Stephan Kamholz, Abhinav Binod Chandra
Background: Pulmonary mucoepidermoid carcinoma (PMEC) and pulmonary adenoid cystic carcinoma (PACC) are the two major types of primary salivary gland-type (PSGT) lung cancers. The demographic profile, clinicopathological features, and predictors of survival as an overall group have not been described for PSGT cancers of lung. Methods: In this study, we analyzed demographic, clinical, and survival data from 1,032 patients (546 PMEC and 486 PACC) who were diagnosed of PSGT lung cancer in the Surveillance, Epidemiology and End Results database from 1973 to 2014...
2018: Frontiers in Oncology
Manas Bajpai, Nilesh Pardhe
Adenoid cystic carcinoma (ACC) is a malignant tumor of salivary glands characterized histopathologically by biphasic epithelial tumor comprised of myoepithelial and ductal cells. There is a paucity of the literature regarding the immunohistochemical labelling of ACC arising in minor salivary glands. This paper reports an additional case of palatal ACC with an emphasis on its immunohistochemical staining using three different markers. Immunohistochemistry allows a better differentiation of ACC with its closest imitators, like polymorphous low grade adenocarcinoma (PLGA), considering that the latter is lesser aggressive and demands a lesser aggressive treatment approach...
June 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Timothy Els, Ian Paul Olwoch
INTRODUCTION: Otitis media with effusion (OME) is a leading cause of acquired hearing loss in children worldwide. However, previous South African studies have consistently reported the local paediatric OME prevalence to be lower than typically published in international literature. Furthermore, no South African studies have investigated OME in children with adenotonsillar hypertrophy. The objective of this study was to determine the prevalence of OME in children admitted for adeno-tonsillectomy at our institution in Pretoria, South Africa...
July 2018: International Journal of Pediatric Otorhinolaryngology
Ahmed Eweiss, Chadwan Al Yaghchi, Sunil Sharma, Phui Yee Wong
OBJECTIVES: The aim of the study is to compare the degree of posterior choanal obstruction caused by adenoidal hypertrophy intra-operatively, when assessed by mirror versus rigid nasendoscopic examination, in children undergoing adenoidectomy. METHODS: This is a prospective blinded study including all consecutive paediatric cases undergoing adenoidectomy under care of the senior author during the period from June 2015 to December 2016. All cases were performed under general anaesthesia...
July 2018: International Journal of Pediatric Otorhinolaryngology
Mian Xie, Shenhai Wei, Xiaojun Wu, Xiaoxiang Li, You You, Chaosheng He
INTRODUCTION: Adenoid cystic carcinoma (ACC) of the trachea lacks of well-characterized molecular markers. There is currently no specific treatment for metastatic ACC of the trachea. This study aimed to identify genomic mutations of Notch pathway and investigate the efficacy of NOTCH inhibitor in ACC of the trachea. METHODS: 73 Patients with ACC of the trachea at four institutions from 2008 to 2016 were identified. Analysis of hotspot mutations in cancer-related genes of Notch pathway was performed using next generation sequencing...
July 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
Wei-Jie Guan, Shi-Yue Li, Nan-Shan Zhong
Pulmonary adenoid cystic carcinoma (ACC) is a rare type of non-small cell lung carcinoma that may develop life-threatening severe malignant airway obstruction (SMAO). Currently, limited therapeutic approaches exist for ACC-SMAO. We investigated the efficacy and safety of para-toluenesulfonamide (PTS) intratumoral injection for ACC-SMAO. In this phase III, multicenter, non-randomized, single-arm, open-label trial, we recruited eight hospitalized patients with ACC-SMAO between October 2009 and January 2011. Within the first year, patients received PTS injection for 2-3 sessions weekly, with 2 weeks as a single course...
April 2018: Journal of Thoracic Disease
Daniela Adorno-Farias, Vinícius Rio Verde Melo Muniz, Amanda Pinheiro Soares, Patrícia Ramos Cury, Rosângela Góes Rabelo, Ricardo Fernández-Ramires, Roberto Almeida de Azevedo, Jean Nunes Dos Santos
BACKGROUND: Ameloblastoma with adenoid features are characterized by the presence of duct-like structures formed from the parenchyma of the tumor. This study was conducted to report a series of eight ameloblastomas with adenoid features, highlighting their clinicopathological and immunohistochemical aspects. MATERIAL AND METHODS: Out of 71 cases of ameloblastomas, this study classified 8 cases as ameloblastomas with adenoid features. Clinicopathological data and immunohistochemistry for CK7, CK14, CK19, IMP3, p53 and Ki-67 were evaluated...
May 21, 2018: Acta Histochemica
Y Y She, M Zhang, X L Nong
Objective: This Meta-analysis was performed to explore the association between survivin expression and clinical pathological features of salivary gland adenoid cystic carcinoma (SACC). Method: Literature was searched in some databases such as PubMed, Embase, Cochrane Library, web of science, OVID, Springerlink, CNKI, CBM, Wanfang and CQVIP. The pooled odds ratios ( ORs ) and 95% confidence intervals (95% CIs ) were estimated to determine the correlation between survivin expression and SACC using a fixed or random effects model according to heterogeneity...
June 20, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
W Li, L Yang, M Chen, M M Zhang, Y K Zhang
Objective: To evaluate the feasibility of immediate reconstruction of facial nerve defect by using cable grafting of the greater auricular nerve after parotid cancer resection. Method: Clinical data of 11 patients suffering from parotid cancer was reviewed.9 cases were diagnosed as mucoepidermoid carcinoma and 2 cases were adenoid cystic carcinoma. Total parotidectomy and elective neck dissection were performed before cable grafting of the greater auricular nerve was interposed between stumps of facial nerve trunk and its branches...
August 20, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
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