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Albert Y Wu, Michael G Daniel
With the rapid growth of the stem cell biology field, the prospect of regenerative medicine across multiple tissue types comes closer to reality. Several groundbreaking steps paved the way for applying stem cell biology to the several subfields within ophthalmology and oculoplastic surgery. These steps include the use of stem cell transplants as well as studies of various ophthalmologic pathologies at the molecular level. The necessity of stem cell transplant is readily apparent, having already been used for several studies such as artificial lacrimal gland design and eyelid reconstruction...
April 2017: Taiwan Journal of Ophthalmology
Haifa Zaibi, Jihen Ben Amar, Hatem Frikha, Besma Dhahri, Hichem Aouina
No abstract text is available yet for this article.
November 2016: La Tunisie Médicale
Gülistan Karadeniz, Zehra Yaşar, Fatma Üçsular, Gülcan Ürpek, Melih Büyükşirin
Persence of multipl primary tumors in an organism is called as multiple primary cancer (MPC). Multipl tumors that occur at the same time are synchronized tumors, while those occuring at the different times called metachronous. MPCs are very rare entities. Here in we report a 96-year-old man who presented with synchronous MPC including squamous cell Lung cancer and tongue adenoid cystic carcinoma.
June 2017: Tüberküloz Ve Toraks
Frank J Barbiero, Anita J Huttner, Joachim M Baehring, Benjamin L Judson
Leiomyosarcomas are malignant tumors displaying strong smooth muscle differentiation [ 1 ]. They can often develop within the GI tract and myometrium, but are particularly rare in the head and neck [ 2 , 3 ]. Perineurial spread of head and neck cancer is observed in patients with neoplasms of the skin (squamous cell carcinoma, melanoma) or skin appendages (adenoid cystic carcinoma) [ 4-6 ]. We report the case of a woman who presented with diplopia and headaches. MRI showed an infratemporal mass lesion and faint enhancement tracking along the mandibular nerve into the wall of the right cavernous sinus...
October 9, 2017: CNS Oncology
Laura Samara, Eduard Esteller, Maria J Dura, Miquel Guirao, Alda Cardesin, Michael Stewart, Francisco Larrosa
OBJECTIVES/HYPOTHESIS: The Tonsil and Adenoid Health Status Instrument (TAHSI) is a disease-specific questionnaire, intended for completion by parents, for assessing quality of life related to tonsil and adenoid disease or its treatment in children with throat disorders. The aim of this study was to validate the Spanish adaptation of the TAHSI, thus allowing comparison across studies and international multicenter projects. STUDY DESIGN: Multicenter prospective instrument validation study...
October 9, 2017: Laryngoscope
A I Kryukov, G Yu Tsarapkin, O V Zairat'yants, A Yu Ivoilov, S G Arzamazov
The authors studied the age-related features of the vascular organization of the adenoid tissue. A total of 46 subjects (n=46) were examined; they were divided into two groups one of which included subjects at the age from 7 to 12 years (n=25) whereas the other group was comprised of 21 subjects at the age from 18 to 42 years (n=21). 29 participants of the study were men (63%) and 17 (37%) women. The histological examination of the adenoid tissue revealed the characteristic changes in the adenoid vasculature in the subjects of either age-group...
2017: Vestnik Otorinolaringologii
Evrim Sürer Budak, Şenay Yıldırım, Sevim Yıldız, Ali Ozan Öner, Şeyda Gündüz
Adenoid cystic carcinoma (ACC) is a rare epithelial malignancy arising from secretory glands, particularly the salivary glands. It tends to invade nerves and has a high potential for distant hematogenous metastasis, especially to the lungs, bone, liver and brain. The breast and hypophysis are not common sites of ACC metastatic disease. Herein, we report a case of ACC of the head and neck region with two unusual sites of metastases, the hypophysis and breast.
October 3, 2017: Molecular Imaging and Radionuclide Therapy
Alessandra C Schmitt, Christopher C Griffith, Cynthia Cohen, Momin T Siddiqui
BACKGROUND: Lymphoid enhancer binding factor 1 (LEF-1) has recently been reported as a potential immunohistochemical (IHC) marker for basal cell adenoma (BCA) and other salivary gland tumors, which may contribute to an increased accuracy in differentiating basaloid salivary gland neoplasms. We evaluated the utility of LEF-1 in fine needle aspiration (FNA) and resection specimens to distinguish pleomorphic adenoma (PA), BCA, basal cell adenocarcinoma (BCAC), and adenoid cystic carcinoma (ACC) as well as in non-neoplastic salivary gland (NNSG)...
October 3, 2017: Diagnostic Cytopathology
Alexander N Goel, Karam W Badran, Adam P G Braun, Alexander M Garrett, Jennifer L Long
Objective We sought to describe the patient, tumor, and survival characteristics of minor salivary gland carcinoma (MSGC) of the oropharynx using a large, population-based database. Study Design Cross-sectional analysis of the National Cancer Institute's SEER database (Surveillance, Epidemiology. and End Results). Subjects and Methods We reviewed the SEER database for all cases of MSGC of the oropharynx from 1988 to 2013. Relevant demographic, clinicopathologic, and survival variables were extracted and analyzed...
September 1, 2017: Otolaryngology—Head and Neck Surgery
Hidetaka Nomura, Minoru Nagashima, Yoichi Aoki, Nobuhiro Takeshima
OBJECTIVE: Some sections of the pelvic bone can be removed without severe loss of function, including the inferior pubic ramus. Here we report a technique for the complete resection of locally advanced adenoid cystic carcinoma (ACC) of the Bartholin's gland that had invaded the obturator muscle and inferior pubic ramus. METHODS: We chose to operate because there was little evidence of definitive radiotherapy for ACC of the vulva. As preoperative imaging did not suggest lymph node metastasis, we omitted lymphadenectomy...
September 26, 2017: Gynecologic Oncology
Weiwei Wang, Jialei Ma, Furong Jin, Jianxing Liao
Salivary adenoid cystic carcinoma (SACC) is associated with a high rate of lung metastasis. When lung metastasis occurs, the effects of traditional chemotherapy on SACC are poor. Hyperbranched polymer drug delivery (degradable hyperbranched polyglycerols, dHPGs) can be used as a strategy to load several drugs, and obtain beneficial effects on SACC lung metastasis through enhanced permeability and retention. In the present study, hydroxycamptothecin (HPT)-conjugated dHPG (dHPG-HPT) was synthesized and its effects on SACC xenografts in the lungs of nude mice were evaluated...
October 2017: Experimental and Therapeutic Medicine
Hiroyuki Hirakawa, Takayoshi Kiba, Yuko Saito, Yoshiteru Watanabe, Takahiro Suzuki, Nobuo Ota
Adenoid cystic carcinoma (ACC) is a rare form of adenocarcinoma, which is a broad term describing any cancer that begins in the glandular tissues. It can be found in the head and neck. We report a patient with recurrent ACC arising from the submandibular gland, treated with 100 mg/m(2) nedaplatin every 4 weeks. Although our patient's lactate dehydrogenase levels, which is produced by ACC, showed a rising trend throughout the treatment, the level decreased for approximately 2 weeks immediately after administration of nedaplatin every 4 weeks...
May 2017: Case Reports in Oncology
Chiara Pavoni, Elisabetta Cretella Lombardo, Lorenzo Franchi, Roberta Lione, Paola Cozza
OBJECTIVE: To evaluate the craniofacial changes induced by functional appliances with special regard to the oro and nasopharyngeal sagittal airway dimensions in subjects with dentoskeletal Class II malocclusions when compared with an untreated Class II control group immediately after therapy and at long-term observation. METHODS: A group of 40 patients (21 females and 19 males) with Class II malocclusion treated consecutively either with a Bionator or an Activator followed by fixed appliances was compared with a matched control group of 31 subjects (16 females and 15 males) with untreated Class II malocclusion...
October 2017: International Journal of Pediatric Otorhinolaryngology
Hongyan Liu, Yibo Zhang, Ting Zhang, Feitian Li, Chunfu Dai
BACKGROUND: The purpose of this study was to analyze the correlation between the pathology and clinical presentations in patients with adenoid cystic carcinoma (ACC) of the external auditory canal. METHODS: Twenty-nine patients with ACC of the external auditory canal who underwent surgery were retrospectively reviewed. RESULTS: Fifty percent of patients with solid pattern disease had recurrences, followed by those with cribriform (33%) and tubular (0%) pattern...
September 30, 2017: Head & Neck
J S Ross, L M Gay, K Wang, J-A Vergilio, J Suh, S Ramkissoon, H Somerset, J M Johnson, J Russell, S Ali, A B Schrock, D Fabrizio, G Frampton, V Miller, P J Stephens, J A Elvin, D W Bowles
Background: Relapsed/metastatic salivary gland carcinomas (SGCs) have a wide diversity of histologic subtypes associated with variable clinical aggressiveness and response to local and systemic therapies. We queried whether comprehensive genomic profiling could define the tumor subtypes and uncover clinically relevant genomic alterations, revealing new routes to targeted therapies for patients with relapsed and metastatic disease. Patients and methods: From a series of 85 686 clinical cases, DNA was extracted from 40 µm of formalin-fixed paraffin embedded (FFPE) sections for 623 consecutive SGC...
October 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
Qianwei Ni, Jinlong Sun, Chao Ma, Yun Li, Jun Ju, Moyi Sun
PURPOSE: We investigated the expression of neuropilin-1 (NRP1), neuropilin-2 (NRP2), vascular endothelial growth factor-A (VEGF-A), semaphorin-3A (Sema-3A), and semaphorin-3F (Sema-3F) in normal salivary gland (NSG) tissue, nonmetastatic salivary adenoid cystic carcinoma (SACC), and metastatic SACC to better understand their role in intratumoral angiogenesis and hematogenous metastasis of SACC. PATIENTS AND METHODS: The study included 60 SACC patients, equally divided between nonmetastatic SACC and metastatic SACC...
September 7, 2017: Journal of Oral and Maxillofacial Surgery
S Masieri, C Incorvaia, C Cavaliere, G Di Cara, F Frati
The oral cavity is a site of pivotal importance in the immune response to foreign antigens, ensuring tolerance induction to harmless agents but reactivity to potentially noxious antigens. Tolerance or reactivity are driven by a number of secondary lymphoid organs, all belonging to the Waldeyer ring, that include adenoids, tubal, palatine and lingual tonsils. Waldeyer’s ring tissues were acknowledged as implicated not only in the adaptive immune system but also in the innate immune system modulation, involving the toll-like receptors...
July 2017: Journal of Biological Regulators and Homeostatic Agents
Scott A Ness
No abstract text is available yet for this article.
September 1, 2017: Journal of the National Cancer Institute
Mattias K Andersson, Maryam K Afshari, Ywonne Andrén, Michael J Wick, Göran Stenman
Background: Adenoid cystic carcinoma (ACC) is an aggressive cancer with no curative treatment for patients with recurrent/metastatic disease. The MYB-NFIB gene fusion is the main genomic hallmark and a potential therapeutic target. Methods: Oncogenic signaling pathways were studied in cultured cells and/or tumors from 15 ACC patients. Phospho-receptor tyrosine kinase (RTK) arrays were used to study the activity of RTKs. Effects of RTK inhibition on cell proliferation were analyzed with AlamarBlue, sphere assays, and two ACC xenograft models (n = 4-9 mice per group)...
September 1, 2017: Journal of the National Cancer Institute
Suman Das, Yogaraja Dorairaja, Anandakrishnan Kuppusamy
Adenoid cystic carcinoma is a very rare malignancy commonly originating from the salivary glands of the head and neck. It is again very scantily seen in sites like the bronchus. Surgical resection is the mainstay of treatment but many a times the tumour site and size preclude a favourable outcome of surgery and the patient is advised for other forms of local treatment like Radiotherapy. Here, we present a case report of a young female with primary adenoid cystic carcinoma of the bronchus. The tumour was located in the carina and the left bronchus which was obstructing the airway resulting in collapse of the left lung, this resulted in shifting the mediastinum and abdominal structures in to the thorax...
November 2017: Reports of Practical Oncology and Radiotherapy
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