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Placenta implantation

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https://www.readbyqxmd.com/read/29279353/angiogenic-factor-imbalance-precedes-complement-deposition-in-placentae-of-the-bph-5-model-of-preeclampsia
#1
Jennifer L Sones, Audrey A Merriam, Angelina Seffens, Dex-Ann Brown-Grant, Scott D Butler, Anna M Zhao, Xinjing Xu, Carrie J Shawber, Jennifer K Grenier, Nataki C Douglas
Preeclampsia (PE), a hypertensive disorder of pregnancy, is a leading cause of maternal and fetal morbidity and mortality. Although the etiology is unknown, PE is thought to be caused by defective implantation and decidualization in pregnancy. Pregnant blood pressure high (BPH)/5 mice spontaneously develop placentopathies and maternal features of human PE. We hypothesized that BPH/5 implantation sites have transcriptomic alterations. Next-generation RNA sequencing of implantation sites at peak decidualization, embryonic day (E)7...
December 26, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29259074/trophoblast-lineage-specification-differentiation-and-their-regulation-by-oxygen-tension
#2
REVIEW
Ching-Wen Chang, Anna K Wakeland, Mana M Parast
Development of the early embryo takes place under low oxygen tension. Under such conditions, the embryo implants and the trophectoderm, the outer layer of blastocyst, proliferate, forming the cytotrophoblastic shell, the early placenta. The cytotrophoblasts (CTBs) are the so-called epithelial 'stem cells' of the placenta, which, depending on the signals they receive, can differentiate into either extravillous trophoblast (EVT) or syncytiotrophoblast (STB). EVTs anchor the placenta to the uterine wall and remodel maternal spiral arterioles in order to provide ample blood supply to the growing fetus...
January 2018: Journal of Endocrinology
https://www.readbyqxmd.com/read/29212380/%C3%AE-v%C3%AE-3-integrin-and-fibronectin-expressions-and-their-relation-to-estrogen-and-progesterone-during-placentation-in-swine
#3
C Vélez, C Barbeito, M Koncurat
Mammalian pregnancy requires specific interactions between the conceptus and its mother that involve the endocrine system and adhesion molecules. The relation between adhesion molecules and their ligands at the fetal-maternal interface is crucial for developing a successful implantation. Progesterone (P4) and estrogen (E2) secreted by the porcine conceptus are required for the relation to be established. We investigated the expression of αvβ3 integrin and its ligand, fibronectin (FN), at the placental interface, and E2 and P4 concentrations in both serum and maternal and fetal placental extracts during placentation in swine...
December 7, 2017: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
https://www.readbyqxmd.com/read/29211918/decellularized-human-placenta-supports-hepatic-tissue-and-allows-rescue-in-acute-liver-failure
#4
Zurab Kakabadze, Anne Kakabadze, David Chakhunashvili, Lika Karalashvili, Ekaterine Berishvili, Yogeshwar Sharma, Sanjeev Gupta
Tissue engineering with scaffolds to form transplantable organs is of wide interest. Decellularized tissues have been tested for this purpose, although supplies of healthy donor tissues, vascular recellularization for perfusion and tissue homeostasis in engineered organs pose challenges. We hypothesized decellularized human placenta will be suitable for tissue engineering. The universal availability and unique structures of placenta for accommodating tissue, including presence of embedded vessels, were major attractions...
December 6, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29197083/changes-in-ultrasonography-indicators-of-abnormally-invasive-placenta-during-pregnancy
#5
Giuseppe Calì, Ilan E Timor-Trisch, Josè Palacios-Jaraquemada, Ana Monteaugudo, Francesco Forlani, Gabriella Minneci, Francesca Foti, Danilo Buca, Alessandra Familiari, Giovanni Scambia, Marco Liberati, Francesco D'Antonio
OBJECTIVE: To ascertain whether the prevalence of ultrasonography signs of abnormally invasive placenta (AIP) change during pregnancy. METHODS: The present retrospective analysis included women with a prenatal diagnosis of AIP that was confirmed at delivery between January 1, 2007, and April 30, 2017, at the Department of Obstetrics and Gynaecology, Arnas Civico Hospital, Palermo, Italy. Ultrasonography signs of AIP were recorded at four different intervals during pregnancy: early first (6-9 weeks), first (11-14 weeks), second (15-24 weeks), and third trimester (25-36 weeks)...
December 2, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29190766/developmental-peculiarities-in-placentae-of-ovine-uniparental-conceptuses
#6
Roberta Arena, Federica Zacchini, Paola Toschi, Luca Palazzese, Marta Czernik, Grażyna Ewa Ptak
Genomic imprinting is an epigenetic phenomenon regulating mono-allelic expression of genes depending on their parental origin. Defective genomic imprinting is involved in several placental disorders, such as intrauterine growth restriction and pre-eclampsia. Uniparental embryos, having maternal-only or paternal-only genomes (parthenogenotes [PAR] and androgenotes [AND], respectively), are useful models to study placentation. The aim of this work was to reveal the effect of parental genome (maternal and paternal) on placentation...
2017: PloS One
https://www.readbyqxmd.com/read/29181211/placenta-percreta-in-first-trimester-after-multiple-rounds-of-failed-medical-management-for-a-missed-abortion
#7
Jaimin Shah, Eduardo Matta, Fernando Acosta, Natalia Golardi, Cristina Wallace-Huff
Background: The detection of a morbidly adherent placenta (MAP) in the first trimester is rare. Risk factors such as multiparity, advanced maternal age, prior cesarean delivery, prior myomectomy, placenta previa, or previous uterine evacuation place patients at a higher risk for having abnormal placental implantation. If these patients have a first trimester missed abortion and fail medical management, it is important that providers have a heightened suspicion for a MAP. Case: A 24-year-old G4P3003 with 3 prior cesarean deliveries underwent multiple rounds of failed medical management for a missed abortion...
2017: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29160594/leptin-action-in-normal-and-pathological-pregnancies
#8
REVIEW
Antonio Pérez-Pérez, Ayelén Toro, Teresa Vilariño-García, Julieta Maymó, Pilar Guadix, José L Dueñas, Manuel Fernández-Sánchez, Cecilia Varone, Víctor Sánchez-Margalet
Leptin is now considered an important signalling molecule of the reproductive system, as it regulates the production of gonadotrophins, the blastocyst formation and implantation, the normal placentation, as well as the foeto-placental communication. Leptin is a peptide hormone secreted mainly by adipose tissue, and the placenta is the second leptin-producing tissue in humans. Placental leptin is an important cytokine which regulates placental functions in an autocrine or paracrine manner. Leptin seems to play a crucial role during the first stages of pregnancy as it modulates critical processes such as proliferation, protein synthesis, invasion and apoptosis in placental cells...
November 21, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29156994/experimental-diabetes-impairs-maternal-reproductive-performance-in-pregnant-wistar-rats-and-their-offspring
#9
Leticia Bequer, Tahiry Gómez, José L Molina, Alain Álvarez, Claudia Chaviano, Sonia Clapés
The aim of this study was to determine the effect of mild hyperglycemia on metabolism during pregnancy, the maternal reproductive performance, and the characteristics of the offspring in neonatal mild diabetic-induced Wistar rats. The experimental diabetes model was generated by neonatal streptozotocin administration (100 mg of streptozotocin/Kg bw/sc) in female Wistar rats. At adulthood, the control and diabetic group were mated. At the 20th day of gestation, a maternal and fetal blood sample were collected for biochemical measurement...
November 20, 2017: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/29153658/neurological-function-in-children-born-to-preeclamptic-and-hypertensive-mothers-a-systematic-review
#10
REVIEW
Ernesto A Figueiró-Filho, Lauren E Mak, James N Reynolds, Patrick W Stroman, Graeme N Smith, Nils D Forkert, Angelina Paolozza, Matthew T Rätsep, B Anne Croy
BACKGROUND: Offspring whose mothers developed preeclampsia (PE-F1s) show developmental effects that are now being identified, such as cognitive, behavioural, and mood differences compared to offspring from non-complicated pregnancies. We hypothesize that the progressive angiokine dysregulation associated with development of preeclampsia (PE) reflects gene dysregulation in pre-implantation conceptuses, and manifests in all developing fetal tissues rather than exclusively to the placenta...
October 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29115663/endogenous-annexin-a1-anxa1-modulates-early-phase-gestation-and-offspring-sex-ratio-skewing
#11
Cristina Bichels Hebeda, Isabel Daufenback Machado, Isadora Reif-Silva, Jusciele Brogin Moreli, Sonia Maria Oliani, Suchita Nadkarni, Mauro Perretti, Estela Bevilacqua, Sandra H P Farsky
Annexin A1 (AnxA1) is a glucocorticoid-regulated anti-inflammatory protein secreted by phagocytes and other specialised cells. In the endocrine system, AnxA1 controls secretion of steroid hormones and it is abundantly expressed in the testis, ovaries, placenta and seminal fluid, yet its potential modulation of fertility has not been described. Here we observed that AnxA1 knockout (KO) mice delivered a higher number of pups, with a higher percentage of female offsprings. This profile was not dependent on the male features, as sperm from KO male mice did not present functional alterations, and had an equal proportion of Y and X chromosomes, comparable to wild type (WT) male mice...
November 8, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29112458/review-detrimental-effects-of-alcohol-exposure-around-conception-putative-mechanisms
#12
Jacinta I Kalisch-Smith, Karen M Moritz
In western countries, alcohol consumption is widespread in women of reproductive age, and in binge quantities. These countries also continue to have high incidences of unplanned pregnancies, with women often reported to cease drinking after discovering their pregnancy. This suggests the early embryo may be highly exposed to the detrimental effects of alcohol during this periconceptional period. The periconception and pre-implantation windows which includes maturation of the oocyte, fertilisation and morphogenesis of the pre-implantation embryo, are particularly sensitive times of development...
November 7, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/29109081/vitamin-d-the-placenta-and-early-pregnancy-effects-on-trophoblast-function
#13
Ankana Ganguly, Jennifer Ann Tamblyn, Sarah Finn-Sell, Shiao-Yng Chan, Melissa Westwood, Janesh Gupta, Mark Kilby, Stephane R Gross, Martin Hewison
Pregnancy is associated with significant changes in vitamin D metabolism, notably increased maternal serum levels of active vitamin D, 1,25-dihydroxyvitamin (1,25(OH)2D). This appears to be due primarily to increased renal activity of the enzyme 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) that catalyzes synthesis of 1,25(OH)2D, but CYP27B1 expression is also prominent in both the maternal decidua and fetal trophoblast components of the placenta. The precise function of placental synthesis of 1,25(OH)2D remains unclear, but is likely to involve localised tissue-specific responses with both decidua and trophoblast also expressing the vitamin D receptor (VDR) for 1,25(OH)2D...
November 6, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/29106428/modified-acellular-nerve-delivering-pmscs-improve-functional-recovery-in-rats-after-complete-spinal-cord-transection
#14
Ting Tian, Zhenhai Yu, Naili Zhang, Yingwei Chang, Yuqiang Zhang, Luping Zhang, Shuai Zhou, Chunlei Zhang, Guoying Feng, Fei Huang
Due to the poor regeneration capacity of neurons and the inhibitory microenvironment, spontaneous regeneration in spinal cord injury (SCI) remains challenging. Tissue engineering is considered a promising approach for enhancing the regeneration of SCI by reconstructing the inherent structure and improving the microenvironment. In this study, the possibility of engineering a nerve complex, which is constructed by acellular nerve delivering placenta mesenchymal stem cells (PMSCs), was assessed for the recovery of a transected spinal cord...
November 6, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/29070722/a-pronounced-uterine-pro-inflammatory-response-at-parturition-is-an-ancient-feature-in-mammals
#15
Victoria L Hansen, Lauren S Faber, Ali A Salehpoor, Robert D Miller
Regulating maternal immunity is necessary for successful human pregnancy. Whether this is needed in mammals with less invasive placentation is subject to debate. Indeed, the short gestation times in marsupials have been hypothesized to be due to a lack of immune regulation during pregnancy. Alternatively, the maternal marsupial immune system may be unstimulated in the absence of a highly invasive placenta. Transcripts encoding pro-inflammatory cytokines were found to be overrepresented in the whole uterine transcriptome at terminal pregnancy in the opossum, Monodelphis domestica To investigate this further, immune gene transcripts were quantified throughout opossum gestation...
October 25, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/29067442/wnt-%C3%AE-catenin-signaling-pathway-in-trophoblasts-and-abnormal-activation-in-preeclampsia-review
#16
Zhan Zhang, Xiaofang Wang, Linlin Zhang, Ying Shi, Jinming Wang, Huan Yan
Preeclampsia (PE) is one of the most common types of hypertensive disease and occurs in 3‑4% of pregnancies. There are a number of theories on the pathogenesis of PE. Abnormal differentiation of the placenta may lead to failure of trophoblast migration, shallow placenta implantation and placental ischemia/hypoxia, followed by the subsequent occurrence of PE. The Wnt/β-catenin pathway is a canonical Wnt‑signaling pathway that regulates several biological processes, including proliferation, migration, invasion and apoptosis...
August 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29056469/intrauterine-bakri-balloon-and-vaginal-tamponade-combined-with-abdominal-compression-for-the-management-of-postpartum-hemorrhage
#17
Yuna Guo, Renyi Hua, Shoufang Bian, Xianjing Xie, Jue Ma, Yanqin Cai, Suren R Sooranna, Weiwei Cheng
OBJECTIVE: This study sought to investigate the effect of Bakri balloon use and vaginal tamponade combined with abdominal compression for the management of postpartum hemorrhage (PPH). METHODS: This retrospective study reviewed cases of PPH in the International Peace Maternal and Child Health Hospital of China Welfare Institution in Shanghai, China from January 1, 2010 to December 31, 2015. A single use of the intrauterine Bakri balloon was applied in some cases, and additional vaginal tamponade combined with abdominal compression (double compression) was applied in other cases...
October 19, 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/29030490/early-sex-dependent-differences-in-response-to-environmental-stress
#18
Serafin Pérez-Cerezales, Priscila Ramos-Ibeas, Dimitrios Rizos, Pat Lonergan, Pablo Bermejo-Alvarez, Alfonso Gutierrez-Adan
Developmental plasticity enables the appearance of long-term effects in offspring caused by exposure to environmental stressors during embryonic and foetal life. These long-term effects can be traced to pre- and post-implantation development, and in both cases the effects are usually sex-specific. During preimplantation development, male and female embryos exhibit an extensive transcriptional dimorphism mainly driven by incomplete X-chromosome inactivation. These early developmental stages are crucial for the establishment of epigenetic marks that will be conserved throughout development, making it a particularly susceptible period for the appearance of long-term epigenetic-based phenotypes...
October 13, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28977597/tgf-%C3%AE-1-inhibits-human-trophoblast-cell-invasion-by-upregulating-connective-tissue-growth-factor-expression
#19
Jung-Chien Cheng, Hsun-Ming Chang, Peter C K Leung
Appropriate trophoblast invasion into the maternal endometrium is essential for successful human implantation and placentation. Connective tissue growth factor (CTGF), also known as CCN2, is a matricellular protein that is expressed in the placenta. Interestingly, the CTGF expression levels in the placenta and serum from patients with severe preeclampsia or fetal growth restriction are higher than those from healthy controls. However, to date, the role of CTGF in the regulation of trophoblast cell invasion remains unclear...
October 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28941881/historical-evolution-of-ideas-on-eclampsia-preeclampsia-a-proposed-optimistic-view-of-preeclampsia
#20
Pierre-Yves Robillard, Gustaaf Dekker, Gérard Chaouat, Marco Scioscia, Silvia Iacobelli, Thomas C Hulsey
Eclampsia (together with epilepsy) being the first disease ever written down since the beginning of writings in mankind 5000 years ago, we will make a brief presentation of the different major steps in comprehension of Pre-eclampsia. 1) 1840. Rayer, description of proteinuria in eclampsia, 2) 1897 Vaquez, discovery of gestational hypertension in eclamptic women, 3) In the 1970's, description of the "double" trophoblastic invasion existing only in humans (Brosens & Pijnenborg,), 4) between the 1970's and the 1990's, description of preeclampsia being a couple disease...
September 2017: Journal of Reproductive Immunology
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