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https://www.readbyqxmd.com/read/29227306/big-data-analytical-approaches-to-the-nacc-dataset-aiding-preclinical-trial-enrichment
#1
Ming Lin, Pinghua Gong, Tao Yang, Jieping Ye, Roger L Albin, Hiroko H Dodge
BACKGROUND: Clinical trials increasingly aim to retard disease progression during presymptomatic phases of Mild Cognitive Impairment (MCI) and thus recruiting study participants at high risk for developing MCI is critical for cost-effective prevention trials. However, accurately identifying those who are destined to develop MCI is difficult. Collecting biomarkers is often expensive. METHODS: We used only noninvasive clinical variables collected in the National Alzheimer's Coordinating Center (NACC) Uniform Data Sets version 2...
December 7, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29226857/prostate-cancer-detection-using-machine-learning-techniques-by-employing-combination-of-features-extracting-strategies
#2
Lal Hussain, Adeel Ahmed, Sharjil Saeed, Saima Rathore, Imtiaz Ahmed Awan, Saeed Arif Shah, Abdul Majid, Adnan Idris, Anees Ahmed Awan
Prostate is a second leading causes of cancer deaths among men. Early detection of cancer can effectively reduce the rate of mortality caused by Prostate cancer. Due to high and multiresolution of MRIs from prostate cancer require a proper diagnostic systems and tools. In the past researchers developed Computer aided diagnosis (CAD) systems that help the radiologist to detect the abnormalities. In this research paper, we have employed novel Machine learning techniques such as Bayesian approach, Support vector machine (SVM) kernels: polynomial, radial base function (RBF) and Gaussian and Decision Tree for detecting prostate cancer...
November 28, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29226218/clinical-effectiveness-of-the-pocket-creation-method-for-colorectal-endoscopic-submucosal-dissection
#3
Akira Kanamori, Masakazu Nakano, Masayuki Kondo, Takanao Tanaka, Keiichiro Abe, Tsunehiro Suzuki, Hitoshi Kino, Yoshihito Kaneko, Chieko Tsuchida, Kouhei Tsuchida, Naoto Yoshitake, Keiichi Tominaga, Yasuo Imai, Hideyuki Hiraishi
Background and study aims : Endoscopic submucosal dissection (ESD) is a technically advanced procedure for colorectal tumors. Hayashi et al. invented the "pocket-creation method (PCM)," and reported that Is-type lesions with fibrosis could be efficaciously and safely resected. However, only case studies have been published, and there are no previous reports on the usefulness of PCM in colorectal ESD for all lesions, as compared with the conventional method. This study aimed to evaluate the effectiveness and safety of PCM in colorectal ESD...
December 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/29225115/thoracic-disc-herniation-surgical-treatment
#4
REVIEW
C Court, E Mansour, C Bouthors
Thoracic disc herniation is rare and mainly occurs between T8 and L1. The herniation is calcified in 40% of cases and is labelled as giant when it occupies more than 40% of the spinal canal.A surgical procedure is indicated when the patient has severe back pain, stubborn intercostal neuralgia or neurological deficits. Selection of the surgical approach is essential. Midline calcified hernias are approached from a transthoracic incision, while lateralized soft hernias can be approached from a posterolateral incision...
December 7, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29224926/fully-automated-detection-and-quantification-of-macular-fluid-in-oct-using-deep-learning
#5
Thomas Schlegl, Sebastian M Waldstein, Hrvoje Bogunovic, Franz Endstraßer, Amir Sadeghipour, Ana-Maria Philip, Dominika Podkowinski, Bianca S Gerendas, Georg Langs, Ursula Schmidt-Erfurth
PURPOSE: Development and validation of a fully automated method to detect and quantify macular fluid in conventional OCT images. DESIGN: Development of a diagnostic modality. PARTICIPANTS: The clinical dataset for fluid detection consisted of 1200 OCT volumes of patients with neovascular age-related macular degeneration (AMD, n = 400), diabetic macular edema (DME, n = 400), or retinal vein occlusion (RVO, n = 400) acquired with Zeiss Cirrus (Carl Zeiss Meditec, Dublin, CA) (n = 600) or Heidelberg Spectralis (Heidelberg Engineering, Heidelberg, Germany) (n = 600) OCT devices...
December 8, 2017: Ophthalmology
https://www.readbyqxmd.com/read/29221742/early-experience-with-robotic-mitral-valve-repair-with-intra-aortic-occlusion
#6
Risto Kesävuori, Peter Raivio, Janne J Jokinen, Antero Sahlman, Kari Teittinen, Antti Vento
OBJECTIVE: To report the learning curve and early results of robotic mitral valve repairs in comparison with propensity score-matched sternotomy controls after the adoption of a robotic mitral valve surgery program in a university teaching hospital. METHODS: A total of 142 patients underwent robotic mitral valve repair due to degenerative mitral regurgitation between May 2011 and December 2015. Control patients operated on via the conventional sternotomy approach were selected by the use of propensity score analysis resulting in 2 well-matched study groups...
December 5, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29220407/respiratory-resistance-and-reactance-in-adults-with-sickle-cell-anemia-correlation-with-functional-exercise-capacity-and-diagnostic-use
#7
Cirlene de Lima Marinho, Maria Christina Paixão Maioli, Jorge Luis Machado do Amaral, Agnaldo José Lopes, Pedro Lopes de Melo
BACKGROUND: The improvement in sickle cell anemia (SCA) care resulted in the emergence of a large population of adults living with this disease. The mechanisms of lung injury in this new population are largely unknown. The forced oscillation technique (FOT) represents the current state-of-the-art in the assessment of lung function. The present work uses the FOT to improve our knowledge about the respiratory abnormalities in SCA, evaluates the associations of FOT with the functional exercise capacity and investigates the early detection of respiratory abnormalities...
2017: PloS One
https://www.readbyqxmd.com/read/29218666/transition-from-laparoscopic-to-retroperitoneoscopic-approach-for-live-donor-nephrectomy
#8
Zi Qin Ng, Gabrielle Musk, Alethea Rea, Bulang He
BACKGROUND: Laparoscopic donor nephrectomy has become the standard of care due to multiple benefits. Currently, there are various techniques employed with two different approaches: transperitoneal (TLDN) or retroperitoneoscopic (RLDN) approach. There is a lack of data to determine which technique is superior, although the RLDN offers an anatomical advantage by avoidance of manipulation of the intraperitoneal organs. The aims of this study were to explore the merits of RLDN to TLDN and assess the learning curve of transition from TLDN to RLDN...
December 7, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29217447/early-experience-with-fenestrated-endovascular-compared-to-open-repair-of-complex-abdominal-aortic-aneurysms-in-a-high-volume-open-aortic-center
#9
Sarah E Deery, Robert T Lancaster, Anna M Gubala, Thomas F X O'Donnell, Christopher J Kwolek, Mark F Conrad, Richard P Cambria, Virendra I Patel
OBJECTIVE: Early data suggest that FEVAR is feasible but may have higher morbidity and unclear durability compared to open surgical repair (OSR) of complex abdominal aortic aneurysms (CAAA). We compared the early experience following elective FEVAR to traditional OSR of CAAA in a high-volume open aortic center. METHODS: All patients undergoing FEVAR and OSR for elective CAAA from 1/2010-7/2015 were identified. Univariate, multivariable logistic, and Cox hazards modeling were used to compare perioperative and intermediate outcomes...
December 4, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29216923/supervised-learning-for-infection-risk-inference-using-pathology-data
#10
Bernard Hernandez, Pau Herrero, Timothy Miles Rawson, Luke S P Moore, Benjamin Evans, Christofer Toumazou, Alison H Holmes, Pantelis Georgiou
BACKGROUND: Antimicrobial Resistance is threatening our ability to treat common infectious diseases and overuse of antimicrobials to treat human infections in hospitals is accelerating this process. Clinical Decision Support Systems (CDSSs) have been proven to enhance quality of care by promoting change in prescription practices through antimicrobial selection advice. However, bypassing an initial assessment to determine the existence of an underlying disease that justifies the need of antimicrobial therapy might lead to indiscriminate and often unnecessary prescriptions...
December 8, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/29215311/classification-of-breast-cancer-from-ultrasound-imaging-using-a-generic-deep-learning-analysis-software-a-pilot-study
#11
Anton S Becker, Michael Mueller, Elina Stoffel, Magda Marcon, Soleen Ghafoor, Andreas Boss
PURPOSE: To train a generic deep learning software (DLS) to classify breast cancer on ultrasound images and to compare its performance to human readers with variable breast imaging experience. METHODS: In this IRB-approved, HIPAA compliant, retrospective study, all breast ultrasound examinations from January 1, 2014, to December 31, 2014 were reviewed. Patients with postsurgical scars, initially indeterminate, or malignant lesions with histological diagnoses or 2-year follow-up were included...
December 7, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29212679/complications-following-arthroscopic-surgery-of-the-hip-a-systematic-review-of-36-761-cases
#12
N Nakano, L Lisenda, T L Jones, D T Loveday, V Khanduja
AIMS: The number of patients undergoing arthroscopic surgery of the hip has increased significantly during the past decade. It has now become an established technique for the treatment of many intra- and extra-articular conditions affecting the hip. However, it has a steep learning curve and is not without the risk of complications. The purpose of this systematic review was to determine the prevalence of complications during and following this procedure. MATERIALS AND METHODS: Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were used in designing this study...
December 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/29208833/sutureless-27-gauge-needle-assisted-transconjunctival-intrascleral-intraocular-lens-fixation-initial-experience
#13
Aditya Shrikant Kelkar, Rajesh Fogla, Jai Kelkar, Akshay Anil Kothari, Hetal Mehta, Winfried Amoaku
PURPOSE: The purpose of the study was to report our initial experience with the transconjunctival Intrascleral Intraocular Lens (SFIOL) fixation with modified Yamane's double-needle technique and flanged haptics. METHODS: This was a prospective interventional study that enrolled 31 consecutive patients undergoing SFIOL with the modified Yamane's technique. All patients underwent comprehensive evaluation including uncorrected and best-corrected vision, intraocular pressure, ultrasound biomicroscopy, endothelial cell density, and macular thickness using optical coherence tomography (OCT)...
December 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29208807/review-of-manual-small-incision-cataract-surgery
#14
REVIEW
Kamaljeet Singh, Arshi Misbah, Pranav Saluja, Arun Kumar Singh
Cataract surgery has undergone many changes with the size of incision progressively decreasing over time with an incision of 12.0 mm for intracapsular cataract extraction to 2.2-2.8 mm in phacoemulsification. However, phacoemulsification due to high cost and equipment maintenance cannot be employed widely in developing countries. Manual small-incision cataract surgery (MSICS) offers similar advantages with the merits of wider applicability, less time consuming, a shorter learning curve, and lower cost. MSICS can be performed in high-volume setups due to fast technique...
December 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29208537/comprehensive-evaluation-of-the-learning-curve-for-peroral-endoscopic-myotomy
#15
Zuqiang Liu, Xiaocen Zhang, Wei Zhang, Yiqun Zhang, Weifeng Chen, Wenzheng Qin, Jianwei Hu, Mingyan Cai, Pinghong Zhou, Quanlin Li
BACKGROUND & AIMS: Peroral endoscopic myotomy (POEM) is a minimally invasive endoscopic surgical procedure that is effective in treatment for spastic esophageal motility disorders. However, little is known about the learning curve for endoscopists. We aimed to evaluate the effects of various factors on the POEM learning curve. METHODS: We performed a retrospective study of 1346 patients who underwent POEM for achalasia at Shanghai Zhongshan Hospital in China from August 2010 through July 2015...
December 2, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29206866/an-adaptive-map-matching-algorithm-based-on-hierarchical-fuzzy-system-from-vehicular-gps-data
#16
Jinjun Tang, Shen Zhang, Yajie Zou, Fang Liu
An improved hierarchical fuzzy inference method based on C-measure map-matching algorithm is proposed in this paper, in which the C-measure represents the certainty or probability of the vehicle traveling on the actual road. A strategy is firstly introduced to use historical positioning information to employ curve-curve matching between vehicle trajectories and shapes of candidate roads. It improves matching performance by overcoming the disadvantage of traditional map-matching algorithm only considering current information...
2017: PloS One
https://www.readbyqxmd.com/read/29206553/development-of-imminent-mortality-predictor-for-advanced-cancer-impac-a-tool-to-predict-short-term-mortality-in-hospitalized-patients-with-advanced-cancer
#17
Kerin Adelson, Donald K K Lee, Salimah Velji, Junchao Ma, Susan K Lipka, Joan Rimar, Peter Longley, Teresita Vega, Javier Perez-Irizarry, Edieal Pinker, Rogerio Lilenbaum
PURPOSE: End-of-life care for patients with advanced cancer is aggressive and costly. Oncologists inconsistently estimate life expectancy and address goals of care. Currently available prognostication tools are based on subjective clinical assessment. An objective prognostic tool could help oncologists and patients decide on a realistic plan for end-of-life care. We developed a predictive model (Imminent Mortality Predictor in Advanced Cancer [IMPAC]) for short-term mortality in hospitalized patients with advanced cancer...
December 5, 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29206232/behavioral-testing-of-mice-exposed-to-intermediate-frequency-magnetic-fields-indicates-mild-memory-impairment
#18
Kajal Kumari, Hennariikka Koivisto, Matti Viluksela, Kaisa M A Paldanius, Mikael Marttinen, Mikko Hiltunen, Jonne Naarala, Heikki Tanila, Jukka Juutilainen
Human exposure to intermediate frequency magnetic fields (MF) is increasing due to applications like electronic article surveillance systems and induction heating cooking hobs. However, limited data is available on their possible health effects. The present study assessed behavioral and histopathological consequences of exposing mice to 7.5 kHz MF at 12 or 120 μT for 5 weeks. No effects were observed on body weight, spontaneous activity, motor coordination, level of anxiety or aggression. In the Morris swim task, mice in the 120 μT group showed less steep learning curve than the other groups, but did not differ from controls in their search bias in the probe test...
2017: PloS One
https://www.readbyqxmd.com/read/29206004/outcomes-of-endovascular-aortic-repair-in-the-modern-era
#19
Jacob Budtz-Lilly, Anders Wanhainen, Kevin Mani
Monitoring outcomes following endovascular aortic repair (EVAR) is critical. Although evidence from randomized controlled trials has solidified the role of EVAR, the analysis of outcomes and "real-world" data has uncovered limitations, improved the selection of appropriate patients, and underscored the importance of instructions for use. Subsequent studies demonstrated the learning curve of EVAR and gradual improvement of outcomes over time. Outcomes analyses will continue to play an important role, particularly as technological growth of endovascular therapy has enabled treatment of more complex aneurysm pathologies and patients...
December 4, 2017: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29204737/initial-slovenian-experience-with-mitraclip-therapy-careful-selection-of-patients-is-crucial-for-optimal-outcome
#20
Jana Ambrožič, Marta Cvijič, Mojca Bervar, Špela Mušič, Matjaž Bunc
BACKGROUND: MitraClip is a percutaneous mitral repair technology increasingly used for high surgical risk patients with primary or secondary mitral regurgitation. We describe initial Slovenian experience with MitraClip and discuss the importance of identifying the suitable candidates for this procedure. METHODS: We retrospectively analyzed the first 10 patients (mean age 75.6 ± 6.9 years, logistic Euroscore 28.4 ± 10.9%) with severe and moderate to severe mitral regurgitation (8 secondary, 1 primary and 1 mixed etiology) who underwent a MitraClip procedure between January 2015 and February 2017...
December 4, 2017: Wiener Klinische Wochenschrift
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