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Surfactant deficiency

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https://www.readbyqxmd.com/read/27866256/surfactant-free-microemulsion-electrokinetic-chromatography-sf-meekc-with-uv-and-ms-detection-a-novel-approach-for-the-separation-and-esi-ms-detection-of-neutral-compounds
#1
Urška Mohorič, Andrea Beutner, Sebastian Krickl, Didier Touraud, Werner Kunz, Frank-Michael Matysik
Microemulsion electrokinetic chromatography (MEEKC) is a powerful tool to separate neutral species based on differences in their hydrophobic and hydrophilic properties. However, as a major drawback the conventionally used SDS based microemulsions are not compatible with electrospray ionization mass spectrometry (ESI-MS). In this work, a surfactant-free microemulsion (SFME) consisting of water, ethanol, and 1-octanol is used for surfactant-free microemulsion electrokinetic chromatography (SF-MEEKC). Ammonium acetate was added to the SFME enabling electrophoretic separations...
December 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27836807/surfactant-protein-a-a-key-player-in-lung-homeostasis
#2
Nadia Nathan, Jessica Taytard, Philippe Duquesnoy, Guillaume Thouvenin, Harriet Corvol, Serge Amselem, Annick Clement
The respiratory tract is continually exposed to various insults that are a permanent threat to the maintenance of lung homeostasis. Repair of the parenchyma structure, particularly of the alveolar epithelium, requires complex cellular strategies. Among the molecular components that play an important role in these processes are the surfactant proteins (SPs), particularly SP-A. The present review examines current evidence regarding the role of SP-A in lung host defence mechanisms through its implication in innate/adaptive immunity of the lung and epithelium integrity and repair...
November 9, 2016: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/27830194/effect-of-high-fat-diet-on-pulmonary-expression-of-parathyroid-hormone-related-protein-and-its-downstream-targets
#3
Learta Oruqaj, Svenja Forst, Rolf Schreckenberg, Javier Inserte, Marcos Poncelas, Jordi Bañeras, David Garcia-Dorado, Susanne Rohrbach, Klaus-Dieter Schlüter
AIMS: Parathyroid hormone-related protein (PTHrP) is involved in lung development and surfactant production. The latter one requires a paracrine interaction between type II alveolar cells and lipofibroblasts in which leptin triggers PTHrP-induced effects. Whether increased plasma leptin levels, as they occur in high fat diet, modify the expression of PTHrP remains unclear. Furthermore, the effect of high fat diet under conditions of forced pulmonary remodelling such as response to post myocardial infarction remains to be defined...
October 2016: Heliyon
https://www.readbyqxmd.com/read/27812430/synthetic-lung-surfactants-containing-sp-b-and-sp-c-peptides-plus-novel-phospholipase-resistant-lipids-or-glycerophospholipids
#4
Robert H Notter, Rohun Gupta, Adrian L Schwan, Zhengdong Wang, Mohanad Gh Shkoor, Frans J Walther
BACKGROUND: This study examines the biophysical and preclinical pulmonary activity of synthetic lung surfactants containing novel phospholipase-resistant phosphonolipids or synthetic glycerophospholipids combined with Super Mini-B (S-MB) DATK and/or SP-Css ion-lock 1 peptides that replicate the functional biophysics of surfactant proteins (SP)-B and SP-C. Phospholipase-resistant phosphonolipids used in synthetic surfactants are DEPN-8 and PG-1, molecular analogs of dipalmitoyl phosphatidylcholine (DPPC) and palmitoyl-oleoyl phosphatidylglycerol (POPG), while glycerophospholipids used are active lipid components of native surfactant (DPPC:POPC:POPG 5:3:2 by weight)...
2016: PeerJ
https://www.readbyqxmd.com/read/27797625/retraction-nitric-oxide-mediates-relative-airway-hyporesponsiveness-to-lipopolysaccharide-in-surfactant-protein-a-deficient-mice
#5
(no author information available yet)
No abstract text is available yet for this article.
November 2016: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/27793798/epithelial-disruption-of-gab1-perturbs-surfactant-homeostasis-and-predisposes-mice-to-lung-injuries
#6
Kai Wang, Shenlu Qin, Zuyu Liang, Yun Zhang, Yingchun Xu, An Chen, Xiaohong Guo, Hongqiang Cheng, Xue Zhang, Yuehai Ke
GRB2-associated-binding protein 1 (Gab1) belongs to Gab adaptor family (Gabs), which integrates multiple signals in response to the epithelial growth factors. Recent genetic studies identified genetic variants of human Gab1 gene as potential risk factors of asthmatic inflammation. However, Gab1 functions in lungs remain largely unknown. Alveolar type-II cells (AT-IIs) are responsible for surfactant homeostasis, and essentially regulate lung inflammation following various injuries. Here, in vitro knockdown of Gab1 was shown to cause a decrease in surfactant proteins (SPs) in AT-IIs...
October 28, 2016: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/27783217/lung-surfactant-metabolism-early-in-life-early-in-disease-and-target-in-cell-therapy
#7
REVIEW
Elena Lopez-Rodriguez, Gemma Gay-Jordi, Adele Mucci, Nico Lachmann, Anna Serrano-Mollar
Lung surfactant is a complex mixture of lipids and proteins lining the alveolar epithelium. At the air-liquid interface, surfactant lowers surface tension, avoiding alveolar collapse and reducing the work of breathing. The essential role of lung surfactant in breathing and therefore in life, is highlighted by surfactant deficiency in premature neonates, which causes neonatal respiratory distress syndrome and results in early death after birth. In addition, defects in surfactant metabolism alter lung homeostasis and lead to disease...
October 25, 2016: Cell and Tissue Research
https://www.readbyqxmd.com/read/27780343/gene-editing-and-genetic-lung-disease-basic-research-meets-therapeutic-application
#8
Deepthi Alapati, Edward E Morrisey
While our understanding of the genetics and pathology of congenital lung diseases such as surfactant protein deficiency, cystic fibrosis and alpha 1 antitrypsin deficiency is extensive, treatment options are lacking. Since the lung is a barrier organ in direct communication with the external environment, targeted delivery of gene corrective technologies to the respiratory system via intra-tracheal or intranasal routes is an attractive option for therapy. CRISPR/Cas9 gene editing technology is a promising approach to repair or inactivate disease causing mutations...
October 25, 2016: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/27775123/narrow-band-red-emitting-phosphor-batif6-mn-4-preparation-characterization-and-application-for-warm-white-led-devices
#9
Xiaoli Gao, Yan Song, Guixia Liu, Xiangting Dong, Jinxian Wang, Wensheng Yu
As a new class of non-rare-earth red phosphors for high-efficiency warm white light-emitting diodes (white LEDs), Mn(4+) ion activated fluoride compounds have been extensively investigated recently and hold the potential to supersede commercial rare earth doped nitride phosphors. Herein, a series of Mn(4+) ions doped BaTiF6 phosphors have been prepared via the hydrothermal route using citric acid as a surfactant. After a systematic investigation, we illustrate the effects of reaction time, nominal concentration of HF solution, and reaction temperature on the luminescence performance of the phosphor...
October 24, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27770432/fgf10-deficiency-is-causative-for-lethality-in-a-mouse-model-of-bronchopulmonary-dysplasia
#10
Cho-Ming Chao, Faady Yahya, Alena Moiseenko, Caterina Tiozzo, Amit Shrestha, Negah Ahmadvand, Elie El Agha, Jennifer Quantius, Salma Dilai, Vahid Kheirollahi, Matthew Jones, Jochen Wilhem, Gianni Carraro, Harald Ehrhardt, Klaus-Peter Zimmer, Guillermo Barreto, Katrin Ahlbrecht, Rory E Morty, Susanne Herold, Rosanna G Abellar, Werner Seeger, Ralph Schermuly, Jin-San Zhang, Parviz Minoo, Saverio Bellusci
Inflammation-induced FGF10 protein deficiency is associated with bronchopulmonary dysplasia (BPD), a chronic lung disease of prematurely born infants characterized by arrested alveolar development. So far, experimental evidence for a direct role of FGF10 in lung disease is lacking. Using the hyperoxia-induced neonatal lung injury as a mouse model of BPD, the impact of Fgf10 deficiency in Fgf10(+/-) versus Fgf10(+/+) pups was investigated. In normoxia, no lethality of Fgf10(+/+) or Fgf10(+/-) pups was observed...
October 22, 2016: Journal of Pathology
https://www.readbyqxmd.com/read/27740733/imidazolium-based-probes-for-recognition-of-biologically-and-medically-relevant-anions
#11
Rahul Kumar, Sana Sandhu, Prabhpreet Singh, Subodh Kumar
The imidazolium derivatives due to their positive charge possess one of the most polarized and positively charged proton at C2-H to form strong ionic hydrogen bond (also termed as double ionic hydrogen bond) with anions and also provide opportunities for anion - π interactions with electron-deficient imidazolium ring. In the present review article, imidazolium based molecular probes for their ability to recognize inorganic anions like halides, cyanide, perchlorate, carboxylic acids, phosphate, sulfate etc...
October 14, 2016: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/27706723/association-between-functional-polymorphisms-in-the-nitric-oxide-synthase-3-gene-and-pediatric-acute-respiratory-distress-syndrome
#12
L Wei, Y An, J Wang
Nitric oxide mediates multiple physiological functions, including neurotransmission, immune regulation, angiogenesis, antiplatelet activity, and surfactant maturation or secretion. Mice deficient in the nitric oxide synthase 3 (NOS3) gene displayed defective lung vascular development and fatal respiratory distress. Polymorphisms in NOS3 have been reported to be associated with respiratory distress syndrome (RDS). The role of NOS3 polymorphisms as a risk factor for pediatric acute respiratory distress syndrome (PARDS) was evaluated by analyzing the possible functional single nucleotide polymorphisms (SNPs) in the regulatory and coding regions of NOS3...
September 16, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27706130/evolution-of-surfactant-therapy-for-respiratory-distress-syndrome-past-present-and-future
#13
Smeeta Sardesai, Manoj Biniwale, Fiona Wertheimer, Arlene Garingo, Rangasamy Ramanathan
Respiratory distress syndrome (RDS) due to surfactant deficiency is the most common cause of respiratory failure in preterm infants. Tremendous progress has been made since the original description that surfactant deficiency is the major cause of RDS. Surfactant therapy has been extensively studied in preterm infants and has been shown to significantly decrease air leaks and neonatal and infant mortality. Synthetic and animal-derived surfactants from bovine as well as porcine origin have been evaluated in randomized controlled trials...
October 5, 2016: Pediatric Research
https://www.readbyqxmd.com/read/27670912/fatal-respiratory-disease-due-to-a-homozygous-intronic-abca3-mutation-a-case-report
#14
Harry Pachajoa, Felipe Ruiz-Botero, Luis Enrique Meza-Escobar, Vania Alexandra Villota-Delgado, Adriana Ballesteros, Ivan Padilla, Diana Duarte
BACKGROUND: Pulmonary surfactant is a complex mixture of lipids and proteins. Mutations in surfactant protein-C, surfactant protein-D, and adenosine triphosphate-binding cassette subfamily A member 3 have been related to surfactant dysfunction and neonatal respiratory failure in full-term babies. Adenosine triphosphate-binding cassette subfamily A member 3 facilitates the transfer of lipids to lamellar bodies. We report the case of patient with a homozygous intronic ABCA3 mutation. CASE PRESENTATION: We describe a newborn full-term Colombian baby boy who was the son of non-consanguineous parents of mixed race ancestry (Mestizo), who was delivered with severe respiratory depression...
September 26, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27589543/retained-surfactant-catheter-and%C3%A2-pneumothorax-in-a-premature-neonate
#15
J M Ismawan, C Abdallah
Surfactant catheters are used to administer exogenous surfactant as a preventive and therapeutic measure for surfactant deficiency in premature neonates. We describe the case of a retained surfactant catheter in a 700 g premature neonate with associated pneumothorax.
September 16, 2016: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/27579479/photophysical-diversity-of-water-soluble-fluorescent-conjugated-polymers-induced-by-surfactant-stabilizers-for-rapid-and-highly-selective-determination-of-2-4-6-trinitrotoluene-traces
#16
Naader Alizadeh, Alireza Akbarinejad, Arash Ghoorchian
The increasing application of fluorescence spectroscopy in development of reliable sensing platforms has triggered a lot of research interest for the synthesis of advanced fluorescent materials. Herein, we report a simple, low-cost strategy for the synthesis of a series of water-soluble conjugated polymer nanoparticles with diverse emission range using cationic (hexadecyltrimethylammonium bromide, CTAB), anionic (sodium dodecylbenzenesulfonate, SDBS), and nonionic (TX114) surfactants as the stabilizing agents...
September 21, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27565967/effect-of-irradiation-bone-marrow-transplantation-on-alveolar-epithelial-type-ii-cells-is-aggravated-in-surfactant-protein-d-deficient-mice
#17
Christian Mühlfeld, Jens Madsen, Rose-Marie Mackay, Jan Philipp Schneider, Julia Schipke, Dennis Lutz, Bastian Birkelbach, Lars Knudsen, Marina Botto, Matthias Ochs, Howard Clark
Irradiation followed by bone marrow transplantation (BM-Tx) is a frequent therapeutic intervention causing pathology to the lung. Although alveolar epithelial type II (AE2) cells are essential for lung function and are damaged by irradiation, the long-term consequences of irradiation and BM-Tx are not well characterized. In addition, it is unknown whether surfactant protein D (SP-D) influences the response of AE2 cells to the injurious events. Therefore, wildtype (WT) and SP-D(-/-) mice were subjected to a myeloablative whole body irradiation dose of 8 Gy and subsequent BM-Tx and compared with age- and sex-matched untreated controls...
August 26, 2016: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/27526419/prevalence-of-respiratory-tract-infections-allergies-and-assessment-of-humoral-immunity-within-the-malopolska-region-s-cohort-of-11-year-old-children-born-with-extremely-low-birth-weight-in-comparison-with-to-their-term-born-peers
#18
Magdalena Zasada, Małgorzata Klimek, Wojciech Durlak, Monika Kotula, Tomasz Tomasik, Przemko Kwinta
BACKGROUND: Children born with extremely low birth weight (ELBW) have more respiratory tract complications during childhood. Little is known about respiratory and allergy problems in ELBW children at the threshold of adolescence. MATERIALS AND METHODS: A follow-up study was conducted at the age of 11 among ELBW children (n=65) and age-matched controls (n=36). The primary outcomes in the study were the occurrence of respiratory and allergy problems and the rate of hospitalization due to respiratory complications at the age of 11 years, assessed with a questionnaire...
2016: Przegla̧d Lekarski
https://www.readbyqxmd.com/read/27516224/lung-disease-caused-by-abca3-mutations
#19
Carolin Kröner, Thomas Wittmann, Simone Reu, Veronika Teusch, Mathias Klemme, Daniela Rauch, Meike Hengst, Matthias Kappler, Nazan Cobanoglu, Tugba Sismanlar, Ayse T Aslan, Ilaria Campo, Marijke Proesmans, Thomas Schaible, Susanne Terheggen-Lagro, Nicolas Regamey, Ernst Eber, Jürgen Seidenberg, Nicolaus Schwerk, Charalampos Aslanidis, Peter Lohse, Frank Brasch, Ralf Zarbock, Matthias Griese
BACKGROUND: Knowledge about the clinical spectrum of lung disease caused by variations in the ATP binding cassette subfamily A member 3 (ABCA3) gene is limited. Here we describe genotype-phenotype correlations in a European cohort. METHODS: We retrospectively analysed baseline and outcome characteristics of 40 patients with two disease-causing ABCA3 mutations collected between 2001 and 2015. RESULTS: Of 22 homozygous (15 male) and 18 compound heterozygous patients (3 male), 37 presented with neonatal respiratory distress syndrome as term babies...
August 11, 2016: Thorax
https://www.readbyqxmd.com/read/27470911/toll-like-receptor-2-activation-depends-on-lipopeptide-shedding-by-bacterial-surfactants
#20
Dennis Hanzelmann, Hwang-Soo Joo, Mirita Franz-Wachtel, Tobias Hertlein, Stefan Stevanovic, Boris Macek, Christiane Wolz, Friedrich Götz, Michael Otto, Dorothee Kretschmer, Andreas Peschel
Sepsis caused by Gram-positive bacterial pathogens is a major fatal disease but its molecular basis remains elusive. Toll-like receptor 2 (TLR2) has been implicated in the orchestration of inflammation and sepsis but its role appears to vary for different pathogen species and clones. Accordingly, Staphylococcus aureus clinical isolates differ substantially in their capacity to activate TLR2. Here we show that strong TLR2 stimulation depends on high-level production of phenol-soluble modulin (PSM) peptides in response to the global virulence activator Agr...
July 29, 2016: Nature Communications
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