Read by QxMD icon Read

Surfactant deficiency

Rahul Kumar, Sana Sandhu, Prabhpreet Singh, Subodh Kumar
The imidazolium derivatives due to their positive charge possess one of the most polarized and positively charged proton at C2-H to form strong ionic hydrogen bond (also termed as double ionic hydrogen bond) with anions and also provide opportunities for anion - π interactions with electron-deficient imidazolium ring. In the present review article, imidazolium based molecular probes for their ability to recognize inorganic anions like halides, cyanide, perchlorate, carboxylic acids, phosphate, sulfate etc...
October 14, 2016: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
L Wei, Y An, J Wang
Nitric oxide mediates multiple physiological functions, including neurotransmission, immune regulation, angiogenesis, antiplatelet activity, and surfactant maturation or secretion. Mice deficient in the nitric oxide synthase 3 (NOS3) gene displayed defective lung vascular development and fatal respiratory distress. Polymorphisms in NOS3 have been reported to be associated with respiratory distress syndrome (RDS). The role of NOS3 polymorphisms as a risk factor for pediatric acute respiratory distress syndrome (PARDS) was evaluated by analyzing the possible functional single nucleotide polymorphisms (SNPs) in the regulatory and coding regions of NOS3...
September 16, 2016: Genetics and Molecular Research: GMR
Smeeta Sardesai, Manoj Biniwale, Fiona Wertheimer, Arlene Garingo, Rangasamy Ramanathan
Respiratory distress syndrome (RDS) due to surfactant deficiency is the most common cause of respiratory failure in preterm infants. Tremendous progress has been made since the original description that surfactant deficiency is the major cause of RDS. Surfactant therapy has been extensively studied in preterm infants and has been shown to significantly decrease air leaks and neonatal and infant mortality. Synthetic and animal-derived surfactants from bovine as well as porcine origin have been evaluated in randomized controlled trials...
October 5, 2016: Pediatric Research
Harry Pachajoa, Felipe Ruiz-Botero, Luis Enrique Meza-Escobar, Vania Alexandra Villota-Delgado, Adriana Ballesteros, Ivan Padilla, Diana Duarte
BACKGROUND: Pulmonary surfactant is a complex mixture of lipids and proteins. Mutations in surfactant protein-C, surfactant protein-D, and adenosine triphosphate-binding cassette subfamily A member 3 have been related to surfactant dysfunction and neonatal respiratory failure in full-term babies. Adenosine triphosphate-binding cassette subfamily A member 3 facilitates the transfer of lipids to lamellar bodies. We report the case of patient with a homozygous intronic ABCA3 mutation. CASE PRESENTATION: We describe a newborn full-term Colombian baby boy who was the son of non-consanguineous parents of mixed race ancestry (Mestizo), who was delivered with severe respiratory depression...
September 26, 2016: Journal of Medical Case Reports
J M Ismawan, C Abdallah
Surfactant catheters are used to administer exogenous surfactant as a preventive and therapeutic measure for surfactant deficiency in premature neonates. We describe the case of a retained surfactant catheter in a 700 g premature neonate with associated pneumothorax.
September 16, 2016: Journal of Neonatal-perinatal Medicine
Naader Alizadeh, Alireza Akbarinejad, Arash Ghoorchian
The increasing application of fluorescence spectroscopy in development of reliable sensing platforms has triggered a lot of research interest for the synthesis of advanced fluorescent materials. Herein, we report a simple, low-cost strategy for the synthesis of a series of water-soluble conjugated polymer nanoparticles with diverse emission range using cationic (hexadecyltrimethylammonium bromide, CTAB), anionic (sodium dodecylbenzenesulfonate, SDBS), and nonionic (TX114) surfactants as the stabilizing agents...
September 21, 2016: ACS Applied Materials & Interfaces
Christian Mühlfeld, Jens Madsen, Rose-Marie Mackay, Jan Philipp Schneider, Julia Schipke, Dennis Lutz, Bastian Birkelbach, Lars Knudsen, Marina Botto, Matthias Ochs, Howard Clark
Irradiation followed by bone marrow transplantation (BM-Tx) is a frequent therapeutic intervention causing pathology to the lung. Although alveolar epithelial type II (AE2) cells are essential for lung function and are damaged by irradiation, the long-term consequences of irradiation and BM-Tx are not well characterized. In addition, it is unknown whether surfactant protein D (SP-D) influences the response of AE2 cells to the injurious events. Therefore, wildtype (WT) and SP-D(-/-) mice were subjected to a myeloablative whole body irradiation dose of 8 Gy and subsequent BM-Tx and compared with age- and sex-matched untreated controls...
August 26, 2016: Histochemistry and Cell Biology
Magdalena Zasada, Małgorzata Klimek, Wojciech Durlak, Monika Kotula, Tomasz Tomasik, Przemko Kwinta
BACKGROUND: Children born with extremely low birth weight (ELBW) have more respiratory tract complications during childhood. Little is known about respiratory and allergy problems in ELBW children at the threshold of adolescence. MATERIALS AND METHODS: A follow-up study was conducted at the age of 11 among ELBW children (n=65) and age-matched controls (n=36). The primary outcomes in the study were the occurrence of respiratory and allergy problems and the rate of hospitalization due to respiratory complications at the age of 11 years, assessed with a questionnaire...
2016: Przegla̧d Lekarski
Carolin Kröner, Thomas Wittmann, Simone Reu, Veronika Teusch, Mathias Klemme, Daniela Rauch, Meike Hengst, Matthias Kappler, Nazan Cobanoglu, Tugba Sismanlar, Ayse T Aslan, Ilaria Campo, Marijke Proesmans, Thomas Schaible, Susanne Terheggen-Lagro, Nicolas Regamey, Ernst Eber, Jürgen Seidenberg, Nicolaus Schwerk, Charalampos Aslanidis, Peter Lohse, Frank Brasch, Ralf Zarbock, Matthias Griese
BACKGROUND: Knowledge about the clinical spectrum of lung disease caused by variations in the ATP binding cassette subfamily A member 3 (ABCA3) gene is limited. Here we describe genotype-phenotype correlations in a European cohort. METHODS: We retrospectively analysed baseline and outcome characteristics of 40 patients with two disease-causing ABCA3 mutations collected between 2001 and 2015. RESULTS: Of 22 homozygous (15 male) and 18 compound heterozygous patients (3 male), 37 presented with neonatal respiratory distress syndrome as term babies...
August 11, 2016: Thorax
Dennis Hanzelmann, Hwang-Soo Joo, Mirita Franz-Wachtel, Tobias Hertlein, Stefan Stevanovic, Boris Macek, Christiane Wolz, Friedrich Götz, Michael Otto, Dorothee Kretschmer, Andreas Peschel
Sepsis caused by Gram-positive bacterial pathogens is a major fatal disease but its molecular basis remains elusive. Toll-like receptor 2 (TLR2) has been implicated in the orchestration of inflammation and sepsis but its role appears to vary for different pathogen species and clones. Accordingly, Staphylococcus aureus clinical isolates differ substantially in their capacity to activate TLR2. Here we show that strong TLR2 stimulation depends on high-level production of phenol-soluble modulin (PSM) peptides in response to the global virulence activator Agr...
2016: Nature Communications
Rebecca Y Petersen, Emily Royse, Matthew W Kemp, Yuichiro Miura, Andres Noe, Alan H Jobe, Noah H Hillman
BACKGROUND: Mechanical ventilation at birth causes airway injury and lung inflammation in preterm sheep. Continuous positive airway pressure (CPAP) is being increasingly used clinically to transition preterm infants at birth. OBJECTIVE: To test if distending pressures will activate acute phase reactants and inflammatory changes in the airways of fetal, preterm lambs. METHODS: The head and chest of fetal lambs at 128±1 day GA were surgically exteriorized...
2016: PloS One
Farideh Rezaei, Mohammad Shafiei, Gholamreza Shariati, Ali Dehdashtian, Maryam Mohebbi, Hamid Galehdari
INTRODUCTION: ABCA3 glycoprotein belongs to the ATP-binding cassette (ABC) superfamily of transporters, which utilize the energy derived from hydrolysis of ATP for the translocation of a wide variety of substrates across the plasma membrane. Mutations in the ABCA3 gene are knowingly causative for fatal surfactant deficiency, particularly respiratory distress syndrome (RDS) in term babies. CASE PRESENTATION: In this study, Sanger sequencing of the whole ABCA3 gene (NCBI NM_001089) was performed in a neonatal boy with severe RDS...
April 2016: Iranian Journal of Pediatrics
Soren W K Hansen, Katsuki Ohtani, Nitai Roy, Nobutaka Wakamiya
Both the complement system and collectins play important roles in our innate immune system. The collectins, which are characterized by their inclusion of a collagen-like region and a calcium-dependent carbohydrate recognition domain, are pattern recognition molecules and include the well characterized proteins mannan-binding lectin (MBL) and the surfactant proteins SP-A/-D. Collectin liver 1 (CL-L1), collectin kidney 1 (CL-K1) and collectin placenta 1 (CL-P1) are the most recently discovered collectins. Although their function is still under investigation, accumulating information suggests that CL-L1, CL-K1 and CL-P1 play important roles in host defense by recognizing a variety of microorganisms and interacting with effector proteins, including complement components...
October 2016: Immunobiology
Andrew Ferretti, Jarrod R Fortwendel, Sarah A Gebb, Robert A Barrington
Pulmonary alveolar proteinosis (PAP) is a rare lung syndrome caused by the accumulation of surfactants in the alveoli. The most prevalent clinical form of PAP is autoimmune PAP (aPAP) whereby IgG autoantibodies neutralize GM-CSF. GM-CSF is a pleiotropic cytokine that promotes the differentiation, survival, and activation of alveolar macrophages, the cells responsible for surfactant degradation. IgG-mediated neutralization of GM-CSF thereby inhibits alveolar macrophage homeostasis and function, leading to surfactant accumulation and innate immunodeficiency...
July 15, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
Virgilio P Carnielli, Chiara Giorgetti, Manuela Simonato, Luca Vedovelli, Paola Cogo
Respiratory distress syndrome is a common problem in preterm infants and the etiology is multifactorial. Lung underdevelopment, lung hypoplasia, abnormal lung water metabolism, inflammation, and pulmonary surfactant deficiency or disfunction play a variable role in the pathogenesis of respiratory distress syndrome. High-quality exogenous surfactant replacement studies and studies on surfactant metabolism are available; however, the contribution of surfactant deficiency, alteration or dysfunction in selected neonatal lung conditions is not fully understood...
2016: Neonatology
Yongfeng Luo, Hui Chen, Siying Ren, Nan Li, Yuji Mishina, Wei Shi
Deficiency in pulmonary surfactant results in neonatal respiratory distress, and the known genetic mutations in key components of surfactant only account for a small number of cases. Therefore, determining the regulatory mechanisms of surfactant production and secretion, particularly during the transition from prenatal to neonatal stages, is essential for better understanding of the pathogenesis of human neonatal respiratory distress. We have observed significant increase of bone morphogenetic protein (BMP) signaling in neonatal mouse lungs immediately after birth...
July 1, 2016: American Journal of Physiology. Lung Cellular and Molecular Physiology
Ling Chen, Richard Wilson, Ellen Bennett, Graeme R Zosky
BACKGROUND: We have previously shown that vitamin D deficiency has a detrimental impact on lung development. In this study, we aimed to identify the mechanisms linking vitamin D with lung development using a mouse model of dietary manipulation. METHODS: Female offspring were euthanized at different time-points; embryonic day (E)14.5, E17.5 or postnatal day (P)7. Lung tissue was collected for mass spectrometry-based proteomic analysis. Label-free quantitation was used to identify the differentially expressed proteins and ELISA confirmed the expression of selected proteins...
2016: Respiratory Research
Cory M Yamashita, Candice Cybulskie, Scott Milos, Yi Y Zuo, Lynda A McCaig, Ruud A W Veldhuizen
The acute respiratory distress syndrome (ARDS) is characterized by arterial hypoxemia accompanied by severe inflammation and alterations to the pulmonary surfactant system. Published data has demonstrated a protective effect of matrix metalloproteinase-3 (Mmp3) deficiency against the inflammatory response associated with ARDS; however, the effect of Mmp3 on physiologic parameters and alterations to surfactant have not been previously studied. It was hypothesized that Mmp3 deficient (Mmp3(-/-)) mice would be protected against lung dysfunction associated with ARDS and maintain a functional pulmonary surfactant system...
June 2016: Canadian Journal of Physiology and Pharmacology
Daniel Im, Wei Shi, Barbara Driscoll
Clinical and basic experimental approaches to pediatric acute lung injury (ALI), including acute respiratory distress syndrome (ARDS), have historically focused on acute care and management of the patient. Additional efforts have focused on the etiology of pediatric ALI and ARDS, clinically defined as diffuse, bilateral diseases of the lung that compromise function leading to severe hypoxemia within 7 days of defined insult. Insults can include ancillary events related to prematurity, can follow trauma and/or transfusion, or can present as sequelae of pulmonary infections and cardiovascular disease and/or injury...
2016: Frontiers in Pediatrics
Christian Mölleken, Gereon Poschmann, Francesco Bonella, Ulrich Costabel, Barbara Sitek, Kai Stühler, Helmut E Meyer, Wolff H Schmiegel, Niels Marcussen, Michael Helmer, Ole Nielsen, Søren Hansen, Anders Schlosser, Uffe Holmskov, Grith Lykke Sorensen
BACKGROUND: Several comparable mechanisms have been identified for hepatic and pulmonary fibrosis. The human microfibrillar associated glycoprotein 4 (MFAP4), produced by activated myofibroblasts, is a ubiquitous protein playing a potential role in extracellular matrix (ECM) turnover and was recently identified as biomarker for hepatic fibrosis in hepatitis C patients. The current study aimed to evaluate serum levels of MFAP4 in patients with pulmonary fibrosis in order to test its potential as biomarker in clinical practice...
2016: Sarcoidosis, Vasculitis, and Diffuse Lung Diseases: Official Journal of WASOG
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"