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Haifeng Teng, Meng Chen, Ansheng Zou, Haili Jiang, Jichun Han, Long Sun, Chao Feng, Ju Liu
OBJECTIVES: The objective of this study was to investigate the hepatoprotective effect of licochalcone B (LCB) in a mice model of carbon tetrachloride (CCl4)-induced liver toxicity. MATERIALS AND METHODS: Hepatotoxicity was induced in mice by a single subcutaneous injection (SC) of CCl4. The LCB was administered orally once a day for seven days (PO) as pretreatment at three doses of 1, 5, and 25 mg/kg/day. The levels of superoxide dismutase (SOD), malondialdehyde (MDA), glutathione (GSH), glutathione disulfide (GSSG), C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were analyzed by ELISA...
August 2016: Iranian Journal of Basic Medical Sciences
Mohd Roslan Mohd Nor, Ahmad Termizi Abdullah, Abdul Karim Ali
BACKGROUND: Malaysia is a multicultural state comprising three main races: Malays, Chinese and Indians. The three main religions are Islam, Buddhism and Hinduism. Other religions such as Sikhism and Christianity are also practised. Muslims are the majority comprising 67 % of the population. METHODS: This paper is qualitative in nature. It applies historical comparative method in presenting its data. The Undang-undang Melaka (Malacca Laws) was obtained from the monograph available at National Library of Malaysia under the name of Hukum Kanun Melaka...
2016: SpringerPlus
Huimin Qin, Hongtao Li, Xiaolin Zhou, Chen Peng, Honghu Tan, Minxin Wang
Presently, there have been a lot of documents confirmed that aflatoxin B1 could promote the incident rate of hepato-cellular carcinoma, but the specific mechanism is not completely clear. Some evidences showed that it might relate to oxidative stress and inflammatory reaction. So the rat hepato-cellular carcinoma model was applied in this study for being discussed. Aflatoxin B1 was applied for inducing the rats to produce hepato-cellular carcinoma model to evaluate the expression of histopathology and glutathione transferase...
2016: American Journal of Translational Research
Pankaj Sharma, Vivek Tiwari, Shah Alam Khan, Shishir Rastogi
Pigmented villo-nodular synovitis (PVNS) is a common disease entity particularly in the knee joint but its incidence in the foot is quite rare. A case of PVNS of the second toe that presented at the outpatient department with an insidious onset and slowly progressive painful swelling of the toe associated with stiffness is presented. The mass was subsequently excised and the diagnosis confirmed by histo-pathology samples. The patient's symptoms improved significantly after the operation. This case is one of the very few reported cases of PVNS involvement of flexor tendon sheath of the foot...
August 3, 2016: Foot
Keijo Luukko, Päivi Kettunen
The tooth, like many other organs, develops from both epithelial and mesenchymal tissues, and has proven to be a valuable tool with which to investigate organ formation and peripheral innervation. Tooth formation is regulated by local epithelial-mesenchymal tissue interactions, and is closely integrated with stereotypic dental nerve navigation and patterning. Recent analyses of the function and regulation of semaphorin 3A (SEMA3A) have shed light on the regulatory mechanisms that coordinate organogenesis and innervation at the tissue and molecular levels...
August 9, 2016: Cell Adhesion & Migration
Xu-Fu Zhang, Yan Long, Ming Tan, Ting Zhang, Qiong Huang, Xi Jiang, Wen-Fang Tan, Jian-Dong Li, Gui-Fang Hu, Shixing Tang, Ying-Chun Dai
Rotaviruses are known to recognize human histo-blood group antigens (HBGAs) as a host ligand that is believed to play an important role in rotavirus host susceptibility and host range. In this study, paired fecal and saliva samples collected from children with viral gastroenteritis, as well as paired serum and saliva samples collected from the general population in south China were studied to evaluate potential association between rotavirus infections and human HBGA phenotypes. Rotavirus was detected in 75 (28%) of 266 fecal samples and P[8] rotaviruses were found to be the predominant genotype...
October 6, 2016: Scientific Reports
Jeremy J Flint, Brian Hansen, Stephen J Blackband
The following article contains nine diffusion tensor imaging (DTI) datasets acquired with magnetic resonance microscopy (MRM, 15.6 μm in-plane). All data was collected in the region bordering the ventral horn and white matter of cross sections from the spinal cord enlargements along with each sample׳s corresponding tissue histology. These data are collected in fixed spinal cord sections of varying thicknesses taken from rat (2×21 direction DTI datasets), pig (1×21 direction DTI dataset), and human (5×21 direction DTI datasets + 1×6 direction DTI dataset) tissue sources...
December 2016: Data in Brief
Imran Khan Jalbani, Syed M Nazim, Muhammad Usman Tariq, Farahat Abbas
Liver transplantation (LT) is the treatment of choice for localized hepatocellular carcinoma (HCC) associated with cirrhosis. Extra hepatic metastasis is the most common cause of death in these patients. There is very little evidence regarding the natural history and treatment options for patients developing HCC recurrence after LT. Surgical resection offers a unique opportunity for solitary metastasis. We report a 61 year old male with solitary right adrenal metastasis 15 months post LT which was managed with open adrenalectomy...
July 2016: Pakistan Journal of Medical Sciences Quarterly
Sreejesh Shanker, Rita Czakó, Gopal Sapparapu, Gabriela Alvarado, Maria Viskovska, Banumathi Sankaran, Robert L Atmar, James E Crowe, Mary K Estes, B V Venkataram Prasad
Human noroviruses (HuNoVs) cause sporadic and epidemic gastroenteritis worldwide. They are classified into two major genogroups (GI and GII), with each genogroup further divided into multiple genotypes. Susceptibility to these viruses is influenced by genetically determined histo-blood group antigen (HBGA) expression. HBGAs function as cell attachment factors by binding to a surface-exposed region in the protruding (P) domain of the capsid protein. Sequence variations in this region that result in differential HBGA binding patterns and antigenicity are suggested to form a basis for strain diversification...
October 4, 2016: Proceedings of the National Academy of Sciences of the United States of America
Chiharu Yoshimoto, Junko Takahama, Takuya Iwabuchi, Masato Uchikoshi, Hiroshi Shigetomi, Hiroshi Kobayashi
PURPOSE: Heme and iron accumulation due to repeated hemorrhage in endometriosis may contribute to a pivotal role in carcinogenesis. We evaluate the clinical application of MR relaxometry in a series of ovarian endometriosis (OE) and endometriosis-associated ovarian cancer (EAOC). MATERIALS AND METHODS: A prospective study of diagnostic accuracy was conducted among 82 patients (67 OE and 15 EAOC) to compare MR relaxometry and biochemical measurement of cyst fluid total iron concentration...
September 16, 2016: Magnetic Resonance in Medical Sciences: MRMS
Arun V Everest-Dass, Daniel Kolarich, Dana Pascovici, Nicolle H Packer
Human blood group polymorphisms are known to be determined by the expression of A, B or H antigens and the Lewis antigens. Protection against microbial infections has been associated with inheritance of polymorphisms in genes encoding and regulating the expression of ABH and Lewis antigens in bodily secretions and epithelial tissue surfaces, subsequently resulting in the presentation of different glycosylated terminal antigens on the cell surface. We investigated the role of blood group antigens in diversifying the glycosylation of buccal epithelial cells (BEC) that line the oral cavity...
September 17, 2016: Glycoconjugate Journal
Murali G Rao, Dalbir Singh, Rakesh Kumar Vashista, Suresh Kumar Sharma
INTRODUCTION: Microscopic study of the organization of the Subdural Haemorrhage (SDH) verified against the time period can help us in the determination of its age which has serious medico-legal implications. Very few studies concerning the dating of SDH are present in the literature. AIM: This study was conducted for dating the early subdural haemorrhage by routine histopathological stains. MATERIALS AND METHODS: A prospective analytical study was conducted during July 2009 to December 2010...
July 2016: Journal of Clinical and Diagnostic Research: JCDR
S Tuncal, A K Önalan, F Aydoğan, V Unsal, N Yumuşak, Eö Büyükatalay, G Öztürk, N Seyhan, S Celepli, E Devrim, B Kılıçoğlu
Background: The study aims to reveal the effect of 2100 MHz radio frequency radiation (RF) on thyroid tissues of the rats in early and late groups. Material and Method: In this study, 30 healthy female Wistar albino rats, weighting 200 to 256 g each were used. The animals were randomly divided into four groups (groups E1, E2, G1, G2). Groups E2 and G2 served as the control groups. The exposure groups were exposed to 2100 MHz radio frequency radiation emitted by a generator, simulating a 3G-mobile phone for six hours/day, five consecutive days/week, at the same time of the day (between 9 am - 3 pm), for 10 days (group E1) and 40 days (group G1)...
January 15, 2016: West Indian Medical Journal
Julia Lange, Frederik Weil, Christoph Riegler, Florian Groeber, Silke Rebhan, Szymon Kurdyn, Miriam Alb, Hermann Kneitz, Götz Gelbrich, Heike Walles, Stephan Mielke
Human artificial skin models are increasingly employed as non-animal test platforms for research and medical purposes. However, the overall histopathological quality of such models may vary significantly. Therefore, the effects of manufacturing protocols and donor sources on the quality of skin models built-up from fibroblasts and keratinocytes derived from juvenile foreskins is studied. Histo-morphological parameters such as epidermal thickness, number of epidermal cell layers, dermal thickness, dermo-epidermal adhesion and absence of cellular nuclei in the corneal layer are obtained and scored accordingly...
October 2016: Biotechnology Journal
Abdinasir Yusuf Osman, Faez Firdaus Jesse Abdullah, Arifah Abdul Kadir, Abdul Aziz Saharee
Brucella melitensis is one of the major zoonotic pathogens with significant economic implications worldwide. The pathogenicity is complex and not always well understood. Lipopolysaccharide (LPS) remains the major virulent factor of B. melitensis and responsible for the mechanism by which the pathogen causes its deleterious effects. In this study, 84 mice of 6-8 weeks old of both sexes were divided equally into 3 groups; namely Brucella melitensis infected group, lipopolysaccharide (LPS) infected group and control group...
August 31, 2016: Microbial Pathogenesis
A A Adeneye, A S Benebo
Nephrotoxicity remains a common untoward effect of cisplatin therapy with limited effective chemopreventive options available till date. This study aims to evaluate the possible chemopreventive effect and mechanism(s) of action of 2 mgkg-1 and 5 mgkg-1 of Tadalafil in cisplatin-induced nephrotoxic rats. In this study, twenty-five male Wistar rats were randomly divided into five groups (n = 5 rats per group) and daily pretreated with oral doses of distilled water (10 mLkg-1), ascorbic acid (100 mgkg-1), Tadalafil (2 mgkg-1 and 5 mgkg-1) for 7 days before cisplatin (5 mgkg-1, intraperitoneal) was administered...
2016: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
Maria Malm, Kirsi Tamminen, Timo Vesikari, Vesna Blazevic
Norovirus (NoV)-specific antibodies, which block binding of the virus-like particles (VLPs) to the cell receptors are conformation dependent and directed towards the most exposed domain of the NoV capsid VP1 protein, the P2 domain. Limited data are available on the antibodies directed to other domains of the VP1, and even less on the NoV VP1-specific T cell epitopes. In here, BALB/c mice were immunized with six VLPs derived from NoV GII.4-1999, GII.4-2009 (New Orleans), GII.4-2012 (Sydney), GII.12, GI.1, and G1...
October 2016: Molecular Immunology
Usha Kumari, Nidhi Srivastava, Asha Shelly, Preeti Khatri, Sarat N, Dileep Kumar Singh, Shibnath Mazumder
The effect of endosulfan metabolites on fish immune system is not well known. It is also not clear whether endosulfan accumulates in fish immune organs and undergoes metabolic biotransformation in situ. In the present study we investigated the role of headkidney (HK), an important fish immune organ on endosulfan metabolism and the long term effects of endosulfan metabolites on the fish immune system. C. gariepinus (walking catfish) were exposed to 2.884ppb of endosulfan (1/10th LC50) for 30d followed by their maintenance in endosulfan-free water for 30d for recovery...
October 2016: Aquatic Toxicology
Cássia Rubia Bernardo, Ana Vitória Silveira Camargo, Luís Sérgio Ronchi, Amanda Priscila de Oliveira, Eumildo de Campos Júnior, Aldenis Albaneze Borim, Cinara Cássia Brandão de Mattos, Reinaldo Bulgarelli Bestetti, Luiz Carlos de Mattos
Chagas disease, caused by Trypanosoma cruzi, can affect the heart, esophagus and colon. The reasons that some patients develop different clinical forms or remain asymptomatic are unclear. It is believed that tissue immunogenetic markers influence the tropism of T. cruzi for different organs. ABO, Secretor and Lewis histo-blood group systems express a variety of tissue carbohydrate antigens that influence the susceptibility or resistance to diseases. This study aimed to examine the association of ABO, secretor and Lewis histo-blood systems with the clinical forms of Chagas disease...
August 24, 2016: Infection, Genetics and Evolution
Satoshi Ishii, Mohan Amarasiri, Satoshi Hashiba, Peiyi Yang, Satoshi Okabe, Daisuke Sano
Enterobacter sp. strain SENG-6, isolated from healthy human feces, produces histo-blood group antigen (HBGA)-like substances that can bind with human noroviruses. Based on the genome sequence analysis, strain SENG-6 belongs to the species Enterobacter cloacae The genome sequence of this strain should help identify genes associated with the production of HBGA-like substances.
2016: Genome Announcements
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