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https://www.readbyqxmd.com/read/29773184/oral-administration-of-cadmium-depletes-intratesticular-and-epididymal-iron-levels-and-inhibits-lipid-peroxidation-in-the-testis-and-epididymis-of-adult-rats
#1
Sunny O Abarikwu, Sarah Oruitemeka, Ifeyinwa A Uwadileke, Stephen I Omeodu, Ngozi F Okoye, Chidimma J Mgbudom-Okah, Robinson Ohanador
Cadmium (Cd)-induced tissue injury depends on the accumulated Cd which differentially affects endogenous iron (Fe). To investigate this, adult rats were treated by oral gavage with Cd (50 mg/kg body wt.) once a week for 15, 30 and 60 days and sacrificed a day after last administration. After the 15th and 30th day of treatment, Cd had no effect on thiobarbituric acid reactive substances (TBARS) and endogenous Fe levels but exhibited anti-androgenic effects (p < 0.05) and caused histological damages...
July 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29762331/rare-location-for-pilonidal-sinus-the-nasal-dorsum
#2
Ayhan Kars, Fatma Atalay, Korhan Kilic, Fatih Bingöl, Yusuf Can
Pilonidal sinuses are recurrent chronic inflammatory lesions which may occur due to penetration of hair particles into skin. Herein, the authors report a pilonidal sinus case that is unusually seen on nasal dorsum and totally excised with the open technique rhinoplasty method. A 20-year-old male patient was admitted to the authors' outpatient clinic with complaints of dysmorphism and discharge from nasal dorsum. Physical examination revealed a swelling in nasal dorsum and hair-containing fistula. Excision was performed with an open rhinoplasty approach...
May 14, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29750676/human-leukocyte-antigen-matching-in-organ-transplantation-what-we-know-and-how-can-we-make-it-better-revisiting-the-past-improving-the-future
#3
Anat R Tambur
PURPOSE OF REVIEW: A renaissance for human leukocyte antigen (HLA) testing emerged with the understanding that donor-specific HLA antibodies play a significant role in long-term allograft survival. This renewed focus on donor/recipient histocompatibility led to a recent quest to decipher antibody responses or, as introduced into the transplantation lexicon, 'HLA-epitope matching'. RECENT FINDINGS: Whether matching is at the antigen or the epitope level, in-depth understanding of how histo-incompatibility leads to activation of an immune response is required...
May 9, 2018: Current Opinion in Organ Transplantation
https://www.readbyqxmd.com/read/29716617/focal-dose-escalation-for-prostate-cancer-using-68-ga-hbed-cc-psma-pet-ct-and-mri-a-planning-study-based-on-histology-reference
#4
Constantinos Zamboglou, Benedikt Thomann, Khodor Koubar, Peter Bronsert, Tobias Krauss, Hans C Rischke, Ilias Sachpazidis, Vanessa Drendel, Nasr Salman, Kathrin Reichel, Cordula A Jilg, Martin Werner, Philipp T Meyer, Michael Bock, Dimos Baltas, Anca L Grosu
BACKGROUND: Focal radiation therapy has gained of interest in treatment of patients with primary prostate cancer (PCa). The question of how to define the intraprostatic boost volume is still open. Previous studies showed that multiparametric MRI (mpMRI) or PSMA PET alone could be used for boost volume definition. However, other studies proposed that the combined usage of both has the highest sensitivity in detection of intraprostatic lesions. The aim of this study was to demonstrate the feasibility and to evaluate the tumour control probability (TCP) and normal tissue complication probability (NTCP) of radiation therapy dose painting using 68 Ga-HBED-CC PSMA PET/CT, mpMRI or the combination of both in primary PCa...
May 2, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29694313/paget-s-disease-of-the-male-breast-case-report-and-a-point-of-view-from-actual-literature
#5
M Vergine, A Musella, E Gulotta, F Frusone, Alberto De Luca, F Maceli, A Libia, P Benedetti Panici, M Monti
INTRODUCTION: Paget disease of the nipple in man is a very rare breast cancer, and there are not standard procedures or guidelines. In any cases, a Paget's disease could hide an invasive ductal breast cancer. CASE DESCRIPTION: We report the case of a 77-years old man affected by Alzheimer's disease, who presented to our attention because of an ulcerated palpable mass in the right nipple. A biopsy of the lesion showed "intra-epidermic proliferation of epitelioid cells, associated with linfo-plasmacellular infiltration of superficial dermis, compatible with Paget's disease (pTis)"...
March 2018: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/29689399/primary-focal-intracranial-leptomeningeal-glioma-pfilg-a-case-report-and-review-of-literature
#6
Vinayak Narayan, Amey Savardekar, Nasser Mohammed, Devi Prasad Patra, Maria-Magdalena Georgescu, Anil Nanda
BACKGROUND: Primary focal intracranial leptomeningeal glioma [PFILG] is considered as a rare solitary glial tumor arising from the leptomeninges without brain attachment or evidence of primary neoplasm elsewhere within the neuraxis. We herein report a case of PFILG in left parietal location with a concise review on its clinico-radiological, histopathological and management characteristics. CASE PRESENTATION: A 75 year old lady presented with focal motor seizures involving right upper limb with associated occasional headache...
April 21, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29686882/pyosalpinges-after-hysterosalpingography-in-a-patient-with-lower-genital-tract-infection-and-managed-by-laparoscopic-surgery-in-a-resource-low-tertiary-hospital-case-report-and-literature-review
#7
Thomas Obinchemti Egbe, Fidelia Mbi Kobenge, Metogo Mbengono Junette Arlette, Eugene Belley-Priso
Background: Pyosalpinges (a complication of pelvic inflammatory disease) is infection of the fallopian tubes and the morbidity associated with it has major health implications. We are reporting a case of pyosalpinges diagnosed after hysterosalpingography and managed by laparoscopic surgery at the Douala General Hospital, Cameroon. Case presentation: A 29-year-old single woman, an assistant nurse of the Douala tribe in Cameroon. She is G1P0010 and came to our attention because of secondary infertility of three years duration...
2018: Fertility Research and Practice
https://www.readbyqxmd.com/read/29676221/prognostic-biomarkers-for-cholangiocarcinoma-and-their-clinical-implications
#8
Charupong Saengboonmee, Kanlayanee Sawanyawisuth, Yaovalux Chamgramol, Sopit Wongkham
Cholangiocarcinoma (CCA) is a poorly prognostic cancer with limited treatment options. Most patients have unresectable tumors when they are diagnosed and the chemotherapies provided are of limited benefit. Prognostic markers are therefore necessary to predict the disease outcome, risk of relapse, or to suggest the best treatment option. Areas covered: This article provides an up-to-date review of biomarkers with promising characteristics to be prognostic markers for CCA reported in the past 5 years. The biomarkers are sub-classified into tissue and serum markers...
April 26, 2018: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/29671179/clinical-infection-in-house-rats-rattus-rattus-caused-by-streptobacillus-notomytis
#9
Viktoria Michel, Claudia Ulber, Dietrich Pöhle, Beate Köpke, Katharina Engel, Ute Kaim, Ahmad Fawzy, Sophie Funk, Juliane Fornefett, Christoph Georg Baums, Tobias Eisenberg
Rat bite fever is an under-reported, under-diagnosed emerging zoonosis with worldwide distribution. Besides Spirillum minus, Streptobacillus moniliformis is the major causative microorganism although it usually colonises rats without any clinical signs. A group of house rats (Rattus rattus) kept in a zoo exhibition for educational purposes suffered from neurological signs including disorientation, torticollis, stall walking, ataxia and death. Gross pathological and histo-pathological examinations of the investigated rats revealed high-grade otitis interna et media, from which Streptobacillus notomytis was isolated in pure culture or as the predominant microorganism...
April 18, 2018: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/29663363/cervical-cancer-risk-in-hpv-positive-women-after-a-negative-fam19a4-mir124-2-methylation-test-a-post-hoc-analysis-in-the-pobascam-trial-with-14-year-follow-up
#10
Lise M A De Strooper, Johannes Berkhof, Renske D M Steenbergen, Birgit I Lissenberg-Witte, Peter J F Snijders, Chris J L M Meijer, Daniëlle A M Heideman
DNA methylation analysis of cervical scrapes using FAM19A4 and mir124-2 genes has shown a good clinical performance in detecting cervical cancer and advanced CIN lesions in need of treatment in HPV-positive women. To date, longitudinal data on the cancer risk of methylation test-negative women are lacking. In this study, we assessed the longitudinal outcome of FAM19A4/mir124-2 methylation analysis in an HPV-positive screening cohort with 14 years of follow-up. Archived HPV-positive cervical scrapes of 1040 women (age 29-61 years), who were enrolled in the POBASCAM screening trial (ISRCTN20781131) were tested for FAM19A4/mir124-2 methylation...
April 16, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29621999/histo-epidemiological-profile-of-breast-cancers-among-women-in-the-central-african-republic-about-174-cases
#11
Augustin Balekouzou, Ping Yin, Cavin Epi Bekolo, Christian Maucler Pamatika, Marceline Djeintote, Sylvain Wilfrid Nambei, Bertrand Ba-Mpoutou, Dieubeni Rawago Mandjiza, Chang Shu, Minghui Yin, Tingting Qing, Boniface Koffi
BACKGROUND: Breast cancer (BC) is the most common cancer in women worldwide and leading cause of cancer deaths indeveloping countries. There is very limited data on BC in the Central African Republic. The purpose of this study was to describe the epidemiological and histopathological characteristics of BC in Bangui. METHODS: This retrospective study reviewed cancer data registries and medical records from the Pathology Unit of the National Laboratory in Bangui and the General Surgery and Gyneacology service from 2003 to 2015...
April 5, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29620545/endobronchial-biopsy-in-the-final-diagnosis-of-chronic-obstructive-pulmonary-disease-and-asthma-a-clinicopathological-study
#12
Maria Abdulrahim Arafah, Emad Raddaoui, Faisal Al Kassimi, Esam H Alhamad, Ahmed Amer Alboukai, Ahlam Abdullah Alshedoukhy, Abderrahman Ouban
BACKGROUND: Asthma and chronic obstructive pulmonary disease (COPD) are chronic conditions with an increasing prevalence in developing countries. The evaluation of endobronchial biopsies has emerged as a tool to differentiate between both conditions via the measurement of the reticular basement membrane (RBM) thickness with various conclusions drawn from different studies. OBJECTIVES: Compare the thickness of the RBM between asthma and COPD and evaluate other histomorphological features in both groups...
March 2018: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/29619029/anti-type-vii-collagen-antibodies-are-identified-in-a-subpopulation-of-bullous-pemphigoid-patients-with-relapse
#13
Delphine Giusti, Grégory Gatouillat, Sébastien Le Jan, Julie Plée, Philippe Bernard, Frank Antonicelli, Bach-Nga Pham
Bullous pemphigoid (BP) is an autoimmune bullous skin disease characterized by anti-BP180 and anti-BP230 autoantibodies (AAbs). Mucous membrane involvement is an uncommon clinical feature of BP which may evoke epidermolysis bullosa acquisita, another skin autoimmune disease characterized by anti-type VII collagen AAbs. We therefore evaluated the presence of anti-type VII collagen AAbs in the serum of BP patients with and without mucosal lesions at time of diagnosis and under therapy. Anti-BP180, anti-BP230, and anti-type VII collagen AAbs were measured by ELISA in the serum of unselected patients fulfilling clinical and histo/immunopathological BP criteria at baseline ( n  = 71) and at time of relapse ( n  = 24)...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29617875/genetic-analysis-of-re-emerging-gii-p16-gii-2-noroviruses-in-2016-2017-in-china
#14
Yuanyun Ao, Xin Cong, Miao Jin, Xiaoman Sun, Xiaoman Wei, Jinjin Wang, Qing Zhang, Jiao Song, Jiemei Yu, Jie Cui, Jianxun Qi, Ming Tan, Zhaojun Duan
Background: During 2016-2017, the previously rare GII.P16-GII.2 norovirus suddenly emerged as the predominant genotype causing gastroenteritis outbreaks in China and other countries. Its origin, phylodynamics, and mechanism behind the predominance remain unclear. Methods: Bayesian phylogenetic analyses were performed on 180 full capsid and 150 polymerase sequences of 2016-2017 GII.P16-GII.2 noroviruses in China, and those for all publicly available GII.P16 and GII...
March 29, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29597193/zika-virus-pathogenesis-in-infant-mice-after-natural-transmission-by-the-bite-of-infected-mosquitoes
#15
Pragya D Yadav, Vimal Kumar, Sandeep Kumar, Chandrashekhar S Mote, Triparna D Majumdar, Mangesh Gokhale, Pravin Kore, Devendra T Mourya
OBJECTIVES: The objective of this study was to understand natural disease progression in infant CD1 mice after the bite of Aedes aegypti mosquitoes infected by the Zika virus (ZIKV, MR-766 strain). METHODS: A. aegypti mosquitoes were experimentally infected with ZIKV MR-766 strain via the oral feeding route. Infected mosquitoes were allowed to feed on infant CD1 mice. Sick mice were euthanized, and their organs were collected and subjected to real-time RT-PCR, histo-pathology, and immunohistochemistry...
March 29, 2018: Intervirology
https://www.readbyqxmd.com/read/29593033/human-group-c-rotavirus-vp8-s-recognize-type-a-histo-blood-group-antigens-as-ligands
#16
Xiaoman Sun, Lihong Wang, Jianxun Qi, Dandi Li, Mengxuan Wang, Xin Cong, Ruchao Peng, Wengang Chai, Qing Zhang, Hong Wang, Hongling Wen, George F Gao, Ming Tan, Zhaojun Duan
Group/species C rotaviruses (RVCs) have been identified as important pathogens of acute gastroenteritis (AGE) in children, family-based outbreaks, as well as animal infections. However, little is known regarding their host-specific interaction, infection, and pathogenesis. In this study, we performed serial studies to characterize the function and structural features of a human G4P[lsqb]2[rsqb] RVC VP8* that is responsible for host receptor interaction. Glycan microarrays demonstrated that the human RVC VP8* recognizes type A histo-blood antigens (HBGAs), which was confirmed by synthetic glycan-/saliva-based binding assays, and hemagglutination of red blood cells, establishing a paradigm of RVC VP8*-glycan interactions...
March 28, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29589631/broad-bean-vicia-faba-l-pods-a-rich-source-of-bioactive-ingredients-with-antimicrobial-antioxidant-enzyme-inhibitory-anti-diabetic-and-health-promoting-properties
#17
Faiza Mejri, Slimen Selmi, Alice Martins, Haifa Benkhoud, Tarek Baati, Hedia Chaabane, Leila Njim, Maria L M Serralheiro, Amélia P Rauter, Karim Hosni
This study was aimed at investigating the chemical composition (proximate, minerals, fatty acids and phenolic compounds) and the in vitro (antimicrobial, radical scavenging, anti-acetylcholinesterase and protein denaturing activities) and in vivo (anti-diabetic and histo-protective effects in alloxan-induced diabetic mice) biological activities of broad bean pods (BBPs), a food waste by-product material. The results showed that BBPs have high dietary fiber (57.46%), carbohydrate (18.93%) and protein (13.81%) content versus low fat content (<1%) contributing to a low energy value of 139...
March 28, 2018: Food & Function
https://www.readbyqxmd.com/read/29571562/-a-massive-open-oneline-course-mooc-on-pratical-histology-a-goal-a-tool-a-large-public-return-on-a-first-experience
#18
Sylvie Multon, Laurence Pesesse, Alodie Weatherspoon, Sandra Florquin, Jean-François Van de Poel, Pierre Martin, Grégoire Vincke, Renaud Hoyoux, Raphael Marée, Dominique Verpoorten, Pierre Bonnet, Pascale Quatresooz, Valérie Defaweux
A goal ! The MOOC entitled "Introduction to Histology, A Human Tissue Exploration" correspond to our vision of the practice of General Histology, which is based on the ability to diagnose 5 families of biological tissues. Ultimately, participants must be able to recognize the different types of cells and all the surrounding elements in order to understand how they organize themselves to form tissues with specific functions. A tool ! This know-how is based on reasoning from observations of microscopic structures...
March 20, 2018: Annales de Pathologie
https://www.readbyqxmd.com/read/29562255/quantifying-the-binding-stoichiometry-and-affinity-of-histo-blood-group-antigen-oligosaccharides-for-human-noroviruses
#19
Ling Han, Ruixiang Zheng, Michele R Richards, Ming Tan, Elena N Kitova, Xi Jiang, John S Klassen
Human noroviruses (HuNoVs) are a major cause of acute gastroenteritis. Many HuNoVs recognize histo-blood group antigens (HBGAs) as cellular receptors or attachment factors for infection. It was recently proposed that HuNoV recognition of HBGAs involves a cooperative, multistep binding mechanism that exploits both known and, previously, unknown glycan binding sites. In this study, binding measurements, implemented using electrospray ionization mass spectrometry (ESI-MS), were performed on homodimers of the protruding domain (P dimers) of the capsid protein of three HuNoV strains [Saga (GII...
March 19, 2018: Glycobiology
https://www.readbyqxmd.com/read/29555531/anti-platelet-therapy-does-not-influence-the-outcome-of-patients-undergoing-hepatic-resection-for-colorectal-liver-metastases-an-observational-study
#20
H Boyd-Carson, G Irving, A P Navarro, I C Cameron, D Gomez
AIM: To evaluate the impact of anti-platelet therapy on the outcomes of patients undergoing liver resection for CRLM. Secondary aim was to determine whether anti-platelet therapy influenced histo-pathological changes in CRLM. METHODS: Patients treated with liver resection for CRLM were identified from a prospectively maintained hepatobiliary database during an 11-year period. Collated data included demographics, primary tumour treatment, surgical data, histopathology analysis and clinical outcome...
March 16, 2018: International Journal of Surgery
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