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Neeraj Kumar, Kishore Kumar Krishnani, Sanjay Kumar Gupta, Narendra Pratap Singh
Nanotechnology is a novel arena with promising applications in the field of medicine, industry, and agriculture including fisheries. Cross-disciplinary interactions and the application of this technology in biological systems have led to the innovation of novel nanoparticle antioxidants, which are the subject of our study. In context with above background, we designed an experiment on nano-silver to elucidate its role for mitigation of abiotic and biotic stress. Three diets were formulated viz. silver nanoparticles (Ag-NPs) incorporated at 0...
March 14, 2018: Environmental Science and Pollution Research International
Williams Turpin, Larbi Bedrani, Osvaldo Espin-Garcia, Wei Xu, Mark S Silverberg, Michelle I Smith, David S Guttman, Anne Griffiths, Paul Moayyedi, Remo Panaccione, Hien Huynh, Hillary Steinhart, Guy Aumais, Konstantin Shestopaloff, Levinus A Dieleman, Dan Turner, Andrew D Paterson, Kenneth Croitoru
Heritability analysis of the microbiota has demonstrated the importance of host genotype in defining the human microbiota. The alpha (1,2)-fucosyltransferase 2 encoded by FUT2 is involved in the formation of the H antigen and the SNP, rs601338 is associated with ABO histo-blood group antigen secretion in the intestinal mucosa. Previous studies have provided non replicated results for the association of this polymorphism with the composition and inferred function of intestinal microbiota. We aimed to assess this relationship in a large cohort of 1,190 healthy individuals...
March 13, 2018: Gut Microbes
Julien Puntonet, Volodia Dangouloff-Ros, Raphaël Saffroy, Mélanie Pagès, Felipe Andreiuolo, Jacques Grill, Stéphanie Puget, Nathalie Boddaert, Pascale Varlet
BACKGROUND AND PURPOSE: Molecular alterations were recently added to the WHO 2016 classification of central nervous system (CNS) tumors. We correlated the histological and radiological features of G34R-mutant high-grade gliomas, a recently described hemispheric and supratentorial glioma of children and young adults. MATERIALS AND METHODS: We performed a retrospective multicenter study on the histopathological and MRI results of 12 patients. RESULTS: All tumors were supratentorial...
March 2, 2018: Journal of Neuroradiology. Journal de Neuroradiologie
Vicente Monedero, Javier Buesa, Jesús Rodríguez-Díaz
Rotavirus (RV) and norovirus (NoV) are the major etiological agents of viral acute gastroenteritis worldwide. Host genetic factors, the histo-blood group antigens (HBGA), are associated with RV and NoV susceptibility and recent findings additionally point to HBGA as a factor modulating the intestinal microbial composition. In vitro and in vivo experiments in animal models established that the microbiota enhances RV and NoV infection, uncovering a triangular interplay between RV and NoV, host glycobiology, and the intestinal microbiota that ultimately influences viral infectivity...
February 24, 2018: Viruses
E Boon, M Bel, W van Boxtel, W T A van der Graaf, R J J van Es, S E J Eerenstein, R J Baatenburg de Jong, M W M van den Brekel, L A van der Velden, M J H Witjes, A Hoeben, S M Willems, E Bloemena, L A Smit, S F Oosting, M A Jonker, U E Flucke, C M L van Herpen
Salivary duct carcinoma (SDC) is a subtype of salivary gland cancer with a dismal prognosis and a need for better prognostication and novel treatments. The aim of this national cohort study was to investigate clinical outcome, prognostic factors, Androgen Receptor (AR) and Human Epidermal Growth Factor Receptor 2 (HER2) expression. SDC patients diagnosed between 1990 - 2014 were identified by the Nationwide Network and Registry of Histo- and Cytopathology in the Netherlands (PALGA). Subsequently, medical records were evaluated and pathological diagnoses reviewed...
March 1, 2018: International Journal of Cancer. Journal International du Cancer
Ajay Godwin Potnuri, Lingesh Allakonda, Mangala Lahkar
Chemotherapy induced testicular toxicity is an emerging reason for azoospermia and impotency in males. Cyclophosphamide (CP) is a widely used chemotherapeutic agent to manage neoplastic and non-neoplastic autoimmune diseases. Testicular toxicity along with bladder and hepatotoxicity are its widely reported adverse effects. Crocin (CR) is the digentiobiosyl ester of crocetin, found in the fruits of gardenia (Gardenia jasminoides E.) and dried stigmas of saffron (Crocus sativus L.) possess antioxidant, anti-depressant, anti-tumor and aphrodisiac properties...
February 24, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Piotr Rhone, Barbara Ruszkowska-Ciastek, Kornel Bielawski, Alen Brkic, Elżbieta Zarychta, Barbara Góralczyk, Krzysztof Roszkowski, Danuta Rość
Introduction : Thrombosis is a one of the leading cause of mortality in cancer patients. The aim of the study was to evaluate the concentrations and activities of selected haemostatic parameters in the plasma of patients diagnosed with breast cancer and to make an attempt at finding associations with there levels and selected clinicopathological factors; clinical classification, histological grading, and molecular subtype of breast cancer. Methods: The study involved 145 Caucasian ethnicity women. Eighty-five women aged 45-66 with primary breast cancer without distant metastases (M0)...
February 23, 2018: Bioscience Reports
Tammer Hemdan, Polat Turker, Per-Uno Malmström, Ulrika Segersten
OBJECTIVES: The aim of this study was to test choline-phosphate cytidylyltransferase-α (CCT-α) protein as a biomarker for neoadjuvant cisplatin chemotherapy response in a bladder tumor setting. MATERIALS AND METHODS: A total of 238 patients with T2-T4 bladder cancer enrolled into two prior randomized trials comparing neoadjuvant cisplatin-based chemotherapy (NAC) plus cystectomy with cystectomy only (no-NAC) were used as discovery and validation cohorts. Protein expression was determined with immunohistochemistry and assessed with Histo (H)-scoring...
February 23, 2018: Scandinavian Journal of Urology
Dionysios C Watson, Eirini Moysi, Antonio Valentin, Cristina Bergamaschi, Santhi Devasundaram, Sotirios P Fortis, Jenifer Bear, Elena Chertova, Julian Bess, Ray Sowder, David J Venzon, Claire Deleage, Jacob D Estes, Jeffrey D Lifson, Constantinos Petrovas, Barbara K Felber, George N Pavlakis
B cell follicles in secondary lymphoid tissues represent an immune privileged sanctuary for AIDS viruses, in part because cytotoxic CD8+ T cells are mostly excluded from entering the follicles that harbor infected T follicular helper (TFH) cells. We studied the effects of native heterodimeric IL-15 (hetIL-15) treatment on uninfected rhesus macaques and on macaques that had spontaneously controlled SHIV infection to low levels of chronic viremia. hetIL-15 increased effector CD8+ T lymphocytes with high granzyme B content in blood, mucosal sites and lymph nodes, including virus-specific MHC-peptide tetramer+ CD8+ cells in LN...
February 2018: PLoS Pathogens
Eun-Hyo Cho, Mahmoud Soliman, Mia Madel Alfajaro, Ji-Yun Kim, Ja-Young Seo, Jun-Gyu Park, Deok-Song Kim, Yeong-Bin Baek, Mun-Il Kang, Sang-Ik Park, Jacques Le Pendu, Kyoung-Oh Cho
Some viruses within the Caliciviridae family initiate their replication cycle by attachment to cell surface carbohydrate moieties, histo-blood group antigens (HBGAs) and/or terminal sialic acids (SAs). Although bovine nebovirus (BNeV), one of the enteric caliciviruses, is an important causative agent of acute gastroenteritis in cattle, its attachment factors and possibly other cellular receptors remain unknown. Using a comprehensive series of protein-ligand biochemical assays, we sought to determine whether BNeV recognizes cell surface HBGAs and/or SAs as attachment factors...
February 21, 2018: Journal of Virology
I V Dvorakovskaya, T A Novitskaya, F M Mazitova, S A Skryabin, A S Gordeladze
The paper presents the data available in the literature on the pathogenesis, clinical and morphological, histological and immunohistochemical features of pulmonary sclerosing pneumocytoma (SP). The paper gives the detailed histological and immunohistochemical characteristics of 6 SP cases. The need for the differential diagnosis of SP is determined by the features and complexity of their histo- and morphogenesis within a single tumor and a complex diagnostic study.
2018: Arkhiv Patologii
M A Sattar, M T Sultana, S Ahmed
Branchial arch anomalies are one of the most common congenital anomalies of the neck. Developmental anomalies of the branchial apparatus account for 17% of all pediatric cervical masses. This study aimed to focus on proper diagnosis of branchial anomaly and describe occurrence, presentation, management and outcome of usual and unusual types. This ten-year prospective observational study was conducted from November 2005 to November 2015 including 2-year postoperative follow-up of the patients in Department of ENT, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh...
January 2018: Mymensingh Medical Journal: MMJ
Yuuki Yoshimura, Daisuke Suzuki, Kanae Miyahara
1 H-MRS, which is a method of measuring fat and iron deposits in the liver, has a single voxel spectroscopy imaging method called high-speed T2 -corrected multiecho (HISTO) based on the STEAM method. If HISTO measurement accuracy is high, it will be one of the biomarkers, so the measurement accuracy was examined. We imaged a self-made phantom simulating a known amount of fat and iron deposition in the liver. A regression analysis of HISTO-measured values for hepatic fat phantom was performed. In addition, regression analysis was performed on the hepatic iron phantom for the R2 values obtained from the T2 values measurement and the actually measured value of the HISTO...
2018: Nihon Hoshasen Gijutsu Gakkai Zasshi
Ghazala Jabeen, Farkhanda Manzoor, Arshad Javid, Hamda Azmat, Mateen Arshad, Shafaq Fatima
Health status of freshwater fish, Cirrhina mrigala was studied by qualitative and quantitative histopathological analysis, alterations in frequency/prevalence percentages (%) and histological alteration indices (HAI) in response to metal contaminated sediments of the River Ravi aquatic ecosystem. Histo-structures of gill and liver samples of fish were analyzed and comparison between the degree of damage of the alterations in fish organs was performed after exposure to metal contaminated sediments for 7, 14 and 28 days under semi-static water renewal bioassays...
February 16, 2018: Bulletin of Environmental Contamination and Toxicology
Corina-Maria Botici, Lăcrimioara Covaci, Claudia Judea-Pusta, Andrei Paşcalău
Objective: The main objective of this paper is to emphasize the importance of the early diagnosis of certainty in the cases of acral-acroma malignant melanoma in order to increase the survival rate. Method: The paper is a review of specialty literature and presents a clinical case of acral-acroma malignant melanoma. Clinical case: acral-acroma malignant melanoma with confirmed lymph node metastases and possibly secondary remote dissemination to the skin in a male patient aged 16 years...
2018: Clujul Medical (1957)
Antonio Cortese, Mario Caggiano, Giuseppe Pantaleo, Massimo Amato, Pier P Claudio
BACKGROUND: Mandibular reconstruction after ablative surgery is challenging not only for the amount of bone tissue needed following bone loss after benign or malignant tumor surgical removal, but mainly to reconstruct bone shape and structure necessary for subsequent implant insertion to preserve the function (speech, swallowing and chewing) and aesthetic of the lower face. Several different techniques for maxillary bone defects reconstruction have been described. The aim of our work is to describe a new technique for mandibular reconstruction that uses an intramural distractor, which is placed in one surgical step and without the need for a skin incision...
February 9, 2018: Minerva Stomatologica
B Khadhraoui, M Turk, A S Fabiano-Tixier, E Petitcolas, P Robinet, R Imbert, M El Maâtaoui, F Chemat
There are more than 1300 articles in scientific literature dealing with positive impacts of Ultrasound-Assisted Extraction (UAE) such as reduction of extraction time, diminution of solvent and energy used, enhancement in yield and even selectivity, intensification of diffusion, and eliminating wastes. This present study aims to understand what are the mechanism(s) behind these positive impacts which will help to design a decision tool for UAE of natural products. Different microscopic observations (Scanning Electron Microscopy (SEM), Environmental Scanning Electron Microscopy (e-SEM), Cyto-histochemistry) have been used for spacial and temporal localization of metabolites in rosemary leaves, which is one of the most studied and most important plant for its antioxidant metabolites used in food industry, during conventional and ultrasound extraction...
April 2018: Ultrasonics Sonochemistry
V Montiel, M Alfonso, C Villas, A Valentí
BACKGROUND: Exostoses at the base of the distal phalanx of the great toe are usually asymptomatic. The literature has not generally considered them as the origin of a possible problem resulting from a pressure conflict between hallux and shoe (medial aspect) or second toe (lateral aspect) nor a potential complication of surgical correction of hallux valgus deformity. No studies, to our knowledge, have evaluated its possible correlation with other foot disorders. When one of these neglected exostoses became painful after surgical correction of hallux valgus, we decided to start a study to determine their possible origin, prevalence in daily practice and histo-pathological morphology...
November 13, 2017: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
Shaowei Sang, Xiaoyun Yang
Background: During the winter of 2014-2015, a rarely reported norovirus (NoV) genotype GII.17 was found to have increased its frequency in norovirus outbreaks in East Asia, surpassing the GII.4 NoV infections. GII.17 genotype has been detected for over three decades in the world. The aim of this study is to examine the evolutionary dynamics of GII.17 over the last four decades. Methods: NoV GII.17 sequences with complete or nearly complete VP1 were downloaded from GenBank and the phylogenetic analyses were then conducted...
2018: PeerJ
Andrea Torroni, Chongchen Xiang, Lukasz Witek, Eduardo D Rodriguez, Roberto L Flores, Nikhil Gupta, Paulo G Coelho
WE43 Mg alloy, composed of Mg, Yttrium, Rare Earth elements, and Zirconium, has proved to be a suitable candidate for production of resorbable osteosynthesis implants in both clinical and experimental settings. In a previous study we tested biocompatibility and degradation properties of untreated (as-cast) and artificially aged (T-5) WE43 Mg-alloys as subperiosteal implants on a maxillofacial sheep model. Both the alloy compositions showed excellent biocompatibility, however, with respect to degradation rate, the as-cast form showed increased degradability compared with the T-5...
January 4, 2018: Journal of Cranio-maxillo-facial Surgery
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