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https://www.readbyqxmd.com/read/28090561/diversity-in-rotavirus-host-glycan-interactions-a-sweet-spectrum
#1
REVIEW
Sasirekha Ramani, Liya Hu, B V Venkataram Prasad, Mary K Estes
Interaction with cellular glycans is a critical initial step in the pathogenesis of many infectious agents. Technological advances in glycobiology have expanded the repertoire of studies delineating host glycan-pathogen interactions. For rotavirus, the VP8* domain of the outer capsid spike protein VP4 is known to interact with cellular glycans. Sialic acid was considered the key cellular attachment factor for rotaviruses for decades. Although this is true for many rotavirus strains causing infections in animals, glycan array screens show that many human rotavirus strains bind nonsialylated glycoconjugates, called histo-blood group antigens, in a strain-specific manner...
May 2016: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28081531/viral-nucleic-acids-in-the-serum-are-dependent-on-blood-sampling-site-in-patients-with-clinical-suspicion-of-myocarditis
#2
Agnieszka Pawlak, Maciej Przybylski, Marek Durlik, Katarzyna Gil, Anna M Nasierowska-Guttmejer, Katarzyna Byczkowska, Andrzej Ziemba, Robert J Gil
BACKGROUND: The meaning of viral nucleic acids in the myocardium in many cases is difficult for clinical interpretation, whereas the presence of viral nucleic acids in the serum is a marker of active infection. We determined the diagnostic value of viral nucleic acids in ventricular serum and peripheral serum samples in comparison with endomyocardial biopsy (EMB) specimens in patients with clinically suspected myocarditis. METHODS: The viral nucleic acid evaluation was performed in serum samples and EMB specimens by real-time PCR in 70 patients (age: 47 ± 16 years)...
January 13, 2017: Intervirology
https://www.readbyqxmd.com/read/28050473/evaluation-of-sinonasal-diseases-by-computed-tomography
#3
Rashmi Kandukuri, Suresh Phatak
INTRODUCTION: Computed Tomography (CT) plays an important diagnostic role in patients with sinonasal diseases and determines the treatment. The CT images clearly show fine structural architecture of bony anatomy thereby determining various anatomical variation, extent of disease and characterization of various inflammatory, benign and malignant sinonasal diseases. AIM: To evaluate sensitivity and specificity of CT in diagnosis of sinonasal diseases and to characterise the benign and malignant lesions with the help of various CT parameters...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28047686/we-fg-202-04-decomposition-of-fdg-pet-based-differential-uptake-volume-histograms-in-rectal-cancer-patients
#4
J Schneider, T Vuong, N Tomic, M Hickeson, R Lisbona, F DeBlois, J Seuntjens, S Devic
PURPOSE: The goal of this study is to test the possible use of the analytical decomposition of differential uptake volume histograms (dUVHs) obtained from FDG-PET/CT data to isolate sub-volumes within a tumor known as biological target volumes (BTVs). METHODS: A retrospective study was conducted on a cohort of 20 histo-pathologically confirmed rectal adenocarcinoma patients having PET/CT scans for staging. All patients (T3N0) underwent pre-operative endorectal brachytherapy...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28043933/clinical-biochemical-and-histopathology-features-of-patients-with-glycogenic-hepatopathy
#5
Saurabh Mukewar, Ayush Sharma, Kandace Lackore, Felicity Enders, Michael Torbenson, Patrick S Kamath, Lewis R Roberts, Yogish C Kudva
BACKGROUND & AIMS: Glycogenic hepatopathy, a syndrome characterized by hepatomegaly and increased liver transaminases in patients with type-1 diabetes, has not been well characterized in adults. We describe the clinical, biochemical, and histo-pathology profile of a cohort of patients with glycogenic hepatopathy. We also examined differences between patients with type-1 diabetes with vs without glycogenic hepatopathy. METHODS: We performed a case-control study of patients with type-1 diabetes diagnosed with glycogenic hepatopathy and patients with type-1 diabetes without glycogenic hepatopathy (controls)...
December 30, 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28042330/comparison-of-68-ga-hbed-cc-psma-pet-ct-and-multiparametric-mri-for-gross-tumour-volume-detection-in-patients-with-primary-prostate-cancer-based-on-slice-by-slice-comparison-with-histopathology
#6
Constantinos Zamboglou, Vanessa Drendel, Cordula A Jilg, Hans C Rischke, Teresa I Beck, Wolfgang Schultze-Seemann, Tobias Krauss, Michael Mix, Florian Schiller, Ulrich Wetterauer, Martin Werner, Mathias Langer, Michael Bock, Philipp T Meyer, Anca L Grosu
PURPOSE: The exact detection and delineation of the intraprostatic tumour burden is crucial for treatment planning in primary prostate cancer (PCa). We compared (68)Ga-HBED-CC-PSMA PET/CT with multiparametric MRI (mpMRI) for diagnosis and tumour delineation in patients with primary PCa based on slice by slice correlation with histopathological reference material. METHODOLOGY: Seven patients with histopathologically proven primary PCa underwent (68)Ga-HBED-CC-PSMA PET/CT and MRI followed by radical prostatectomy...
2017: Theranostics
https://www.readbyqxmd.com/read/28040552/chemoprotective-role-of-quercetin-in-manganese-induced-toxicity-along-the-brain-pituitary-testicular-axis-in-rats
#7
Isaac A Adedara, Temitayo I Subair, Valerie C Ego, Oluwasetemi Oyediran, Ebenezer O Farombi
Reproductive dysfunction in response to manganese exposure has been reported in humans and animals. Quercetin, a bioflavonoid widely distributed in fruits, vegetables and beverages has been shown to possess antioxidant, anti-inflammatory and anti-apoptotic activities in different experimental model systems. However, there is dearth of scientific information on the influence of quercetin on manganese-induced reproductive toxicity. This study was designed to evaluate the influence of quercetin on manganese-induced functional alterations along the brain-pituitary- testicular axis in rats...
December 28, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28028431/oncocytic-pleomorphic-adenoma-of-palatal-salivary-gland-with-macrophages-and-giant-cells-associated-with-cholesterol-crystals
#8
Gargi S Sarode, Sachin C Sarode, Shankargouda Patil, Sukumaran Anil
Pleomorphic adenoma (PA) is the most common salivary gland tumor characterized by histo-morphological diversity in the form of myxoid, hyalinized, chondroid, osseous, and squamous areas. In this paper, we report a rare case of predominantly oncocytic variant of PA in a 45-year-old male patient on the posterior palatal region. Microscopic examination showed homogenous eosinophilic cellular mass composed of epithelial components arranged in the form of tubular and solid patterns. The polygonal and oval cells showed abundant dark eosinophilic granular cytoplasm...
October 24, 2016: Clinics and Practice
https://www.readbyqxmd.com/read/28024847/dark-field-imaging-recent-developments-and-potential-clinical-applications
#9
Masami Ando, Naoki Sunaguchi, Daisuke Shimao, Adam Pan, Tetsuya Yuasa, Kensaku Mori, Yoshifumi Suzuki, Ge Jin, Jong-Ki Kim, Jae-Hong Lim, Seung-Jun Seo, Shu Ichihara, Norihiko Ohura, Rajiv Gupta
This paper describes an X-ray phase contrast imaging technique using analyzer-based optics called X-ray Dark-Field Imaging that has been under development for the past 10years. We describe the theory behind XDFI, the X-ray optics required for implementing it in practice, and algorithms used for 2D, 2.5D, and 3D image reconstruction. The XDFI optical chain consists of an asymmetrically cut, Bragg-type monochromator-collimator that provides a planar monochromatic X-ray beam, a positioning stage for the specimens, a Laue-case angle analyzer, and one or two cameras to capture the dark and bright field images...
December 2016: Physica Medica: PM
https://www.readbyqxmd.com/read/27999997/level-i-lymph-node-involvement-in-patients-with-n1b-papillary-thyroid-carcinoma-a-prospective-study
#10
Ahmad M Eweida, Mahmoud F Sakr, Yasser Hamza, Mohamed R Khalil, Essam Gabr, Tarek Koraitim, Hatem F Al-Wagih, Waleed Abo-Elwafa, Tarek Ezzat Abdel-Aziz, Ahmed A Diab, Basma El-Sabaa, Aman S Nabawi
Most of the studies on the incidence, pattern, and predictive factors of lymph node (LN) metastasis with papillary thyroid carcinoma (PTC) have been performed retrospectively and no common consensus has been reached regarding the predictors for the involvement of level I LNs. This study was conducted prospectively to determine the incidence and the possible predictors of level I involvement in N1b PTC patients. The study included 30 consecutive patients with N1b stage of PTC. All the patients underwent neck dissection (ND) including level I...
December 20, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27989878/aphrodisiac-and-spermatogenic-potential-of-alkaloidal-fraction-of-hygrophila-spinosa-t-ander-in-rats
#11
Niraj Y Vyas, Manan A Raval
ETHNOPHARMACOLOGICAL RELEVANCE: Seeds of Hygrophila spinosa T. Ander (Acanthaceae) are traditionally used as aphrodisiac and spermatogenic in Indian System of medicine. AIM OF THE STUDY: Preliminary phytochemical screening of plant revealed the presence of alkaloids in seeds. As, alkaloidal fractions of several plants showed aphrodisiac and spermatogenic potential, set of experiments were designed to assess alkaloid enriched fraction of seeds of the plant for spermatogenic and aphrodisiac activity using in vitro and in vivo methods...
October 29, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27981983/shading-concepts-and-layering-techniques-to-master-direct-anterior-composite-restorations-an-update
#12
D Dietschi, N Fahl
Creating perfect direct composite restorations has been for long time a strict challenge due to many materials' limitations impacting either shade integration or surface quality, and possibly colour stability. Next to technological drawbacks, a certain complexity and lack of predictability in clinical application was inherent to the technique and made it elitist for a long time. Shading and layering concepts then progressively evolved from a simplistic, non histo-anatomical, bilaminar technique to a multi-layering approach (3 to 4 or more layers), following the Vita Classic(™) system...
December 16, 2016: British Dental Journal
https://www.readbyqxmd.com/read/27976423/mohs-micrographic-surgery-of-rare-cutaneous-tumors
#13
Sophie C Flohil, Charlotte B van Lee, Jessica Beisenherz, Marc A M Mureau, Lucy I H Overbeek, Tamar Nijsten, Renate R van den Bos
BACKGROUND: Recurrence rates after Mohs micrographic surgery (MMS) for rare cutaneous tumors are poorly defined. OBJECTIVE: Investigate the recurrence rate after MMS for rare cutaneous tumors at a university center. METHODS & MATERIALS: Retrospective review of all rare cutaneous tumors treated with MMS at a large university center between January 2008 and December 2012. To detect all recurrences, patients were linked to The nationwide network and registry of histo- and cytopathology (PALGA)...
December 15, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27974408/interstitial-fibrosis-functional-status-and-outcomes-in-heart-failure-with-preserved-ejection-fraction-insights-from-a-prospective-cardiac-magnetic-resonance-imaging-study
#14
Franz Duca, Andreas A Kammerlander, Caroline Zotter-Tufaro, Stefan Aschauer, Marianne L Schwaiger, Beatrice A Marzluf, Diana Bonderman, Julia Mascherbauer
BACKGROUND: Myocardial extracellular volume (ECV) accumulation is one of the key pathophysiologic features of heart failure with preserved ejection fraction (HFpEF). Our aims were to (1) measure ECV by cardiac magnetic resonance T1 mapping using the modified Look-Locker inversion recovery (MOLLI) sequence, (2) validate MOLLI-ECV against histology, and (3) investigate the relationship between MOLLI-ECV and prognosis in HFpEF. METHODS AND RESULTS: One-hundred seventeen consecutive HFpEF patients underwent cardiac magnetic resonance imaging, coronary angiography, and invasive hemodynamic assessments at baseline...
December 2016: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/27936429/investigation-of-biomechanical-response-of-hoffa-s-fat-pad-and-comparative-characterization
#15
Chiara Giulia Fontanella, Emanuele Luigi Carniel, Alessandro Frigo, Veronica Macchi, Andrea Porzionato, Gloria Sarasin, Marco Rossato, Raffaele De Caro, Arturo N Natali
The infrapatellar adipose body (Hoffa's fat pad, IFP) is situated between the patellar tendon, the femoral condyle and the tibial plateau. The IFP consists of lobules of white adipose tissue delimited by thin connective septa. The actual structural functionality of the IFP is debated and should pertain to a cushioning role in the knee joint, providing to distribute and to damp mechanical stresses during articular activity. The present study is aimed to analyze the correlation between histological configuration and mechanical properties of the IFP, compared to other adipose tissues, partially differentiated by composition and conformation...
December 1, 2016: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/27918380/genetic-susceptibility-to-norovirus-gii-4-sydney-strain-infections-in-taiwanese-children
#16
Li-Tzu Tu, Fu-Ping Liu, Yhu-Chering Huang, Chung-Guei Huang, Shuan Yang, Kuo-Chien Tsao, Ming-Wei Lai, Chih-Jung Chen
BACKGROUND: A comprehensive evaluation of associations between the susceptibility to norovirus infections and histo-blood group antigens is not available in the Taiwanese population, in which the non-secretor phenotype is absent. METHODS: A 1:1 matched case-control study was conducted in northern Taiwan from February, 2013 to December, 2014 when an epidemic of norovirus infection occurred. Cases were children < 18 years old who were hospitalized because of diarrhea and were found to have laboratory-confirmed norovirus infections...
December 1, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27905110/distinct-molecular-landscapes-between-endometrioid-and-non-endometrioid-uterine-carcinomas
#17
Nathaniel L Jones, Joanne Xiu, Sudeshna Chatterjee-Paer, Alexandre Buckley de Meritens, William M Burke, Ana I Tergas, Jason D Wright, June Y Hou
Endometrial carcinoma (EC) is traditionally characterized as endometrioid and non-endometrioid based on histo-pathologic phenotypes. Molecular-based classifications have been proposed, but are not widely implemented. Herein we examine molecular profiles between EC histologic subtypes. 3133 ECs were submitted between March 2011 and July 2014: 1634 Type I and 1226 Type II. In situ hybridization and immunohistochemistry were used to assess copy number and protein expression of selected genes. Sequenced variants in 47 genes were analyzed using the Illumina TruSeq Amplicon Cancer Panel...
December 1, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27904443/prognosis-estimation-under-the-light-of-metabolic-tumor-parameters-on-initial-fdg-pet-ct-in-patients-with-primary-extranodal-lymphoma
#18
Kursat Okuyucu, Sukru Ozaydın, Engin Alagoz, Gokhan Ozgur, Semra Ince, Fahrettin Guven Oysul, Ozlem Ozmen, Murat Tuncel, Mustafa Ozturk, Nuri Arslan
BACKGROUND: Non-Hodgkin's lymphomas arising from the tissues other than primary lymphatic organs are named primary extranodal lymphoma. Most of the studies evaluated metabolic tumor parameters in different organs and histopathologic variants of this disease generally for treatment response. We aimed to evaluate the prognostic value of metabolic tumor parameters derived from initial FDG-PET/CT in patients with a medley of primary extranodal lymphoma in this study. PATIENTS AND METHODS: There were 67 patients with primary extranodal lymphoma for whom FDG-PET/CT was requested for primary staging...
December 1, 2016: Radiology and Oncology
https://www.readbyqxmd.com/read/27893778/mycobacterium-ulcerans-mouse-model-refinement-for-pre-clinical-profiling-of-vaccine-candidates
#19
Angèle Bénard, Claudia Sala, Gerd Pluschke
Buruli Ulcer is a neglected tropical disease leading to extensive disabilities and morbidity in West Africa. In this paper we sought to characterize various strains of Mycobacterium ulcerans (M.ulcerans) with different origins and laboratory passage records while refining a mouse model for Buruli ulcer. We described, compared and followed the kinetics of the histo-pathological outcome of infection of a collection of strains at various anatomical sites of infection in order to find a suitable model for further immunization studies...
2016: PloS One
https://www.readbyqxmd.com/read/27893352/prevalence-of-antibodies-to-a-new-histo-blood-system-the-fors-system
#20
Carlos Jesus, Camilla Hesse, Clara Rocha, Nádia Osório, Ana Valado, Armando Caseiro, António Gabriel, Lola Svensson, Ali-Reza Moslemi, Wafa Abu Siba, Mahmoud A Srour, Cristina Pereira, Jorge Tomaz, Paulo Teixeira, Fernando Mendes
BACKGROUND: In 1987, three unrelated English families were reported with a putative blood subgroup called Apae. Swedish researchers later found evidence leading to abolishment of the Apae subgroup and establishment instead of the FORS blood group system (System 31 - ISBT, 2012). It is important to know the prevalence of antibodies in order to make the best decisions in transfusion medicine. Cells expressing the Forssman saccharide, such as sheep erythrocytes, are needed to detect the anti-Forssman antibody...
October 24, 2016: Blood Transfusion, Trasfusione del Sangue
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