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CABG LV scar mri

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https://www.readbyqxmd.com/read/24656645/autologous-bone-marrow-mononuclear-cell-transplantation-in-ischemic-heart-failure-a-prospective-controlled-randomized-double-blind-study-of-cell-transplantation-combined-with-coronary-bypass
#1
RANDOMIZED CONTROLLED TRIAL
Tommi Pätilä, Miia Lehtinen, Antti Vento, Jukka Schildt, Juha Sinisalo, Mika Laine, Pekka Hämmäinen, Anne Nihtinen, Riitta Alitalo, Päivi Nikkinen, Aapo Ahonen, Miia Holmström, Kirsi Lauerma, Reino Pöyhiä, Markku Kupari, Esko Kankuri, Ari Harjula
BACKGROUND: Bone marrow mononuclear cell (BMMC) transplantation for heart failure has shown inconsistent therapeutic efficacy. METHODS: We enrolled 104 ischemic heart failure patients scheduled for coronary artery bypass surgery (CABG). After 4- to 12-week pharmacotherapy optimization, 39 patients with left ventricular ejection fraction (LVEF) of ≤45% received injections of BMMC or vehicle intra-operatively into the myocardial infarction border area in a randomized, double-blind manner...
June 2014: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/24565698/autologous-mesenchymal-stem-cells-produce-concordant-improvements-in-regional-function-tissue-perfusion-and-fibrotic-burden-when-administered-to-patients-undergoing-coronary-artery-bypass-grafting-the-prospective-randomized-study-of-mesenchymal-stem-cell-therapy
#2
RANDOMIZED CONTROLLED TRIAL
Vasileios Karantalis, Darcy L DiFede, Gary Gerstenblith, Si Pham, James Symes, Juan Pablo Zambrano, Joel Fishman, Pradip Pattany, Ian McNiece, John Conte, Steven Schulman, Katherine Wu, Ashish Shah, Elayne Breton, Janice Davis-Sproul, Richard Schwarz, Gary Feigenbaum, Muzammil Mushtaq, Viky Y Suncion, Albert C Lardo, Ivan Borrello, Adam Mendizabal, Tomer Z Karas, John Byrnes, Maureen Lowery, Alan W Heldman, Joshua M Hare
RATIONALE: Although accumulating data support the efficacy of intramyocardial cell-based therapy to improve left ventricular (LV) function in patients with chronic ischemic cardiomyopathy undergoing CABG, the underlying mechanism and impact of cell injection site remain controversial. Mesenchymal stem cells (MSCs) improve LV structure and function through several effects including reducing fibrosis, neoangiogenesis, and neomyogenesis. OBJECTIVE: To test the hypothesis that the impact on cardiac structure and function after intramyocardial injections of autologous MSCs results from a concordance of prorecovery phenotypic effects...
April 11, 2014: Circulation Research
https://www.readbyqxmd.com/read/24497345/autologous-cd133-bone-marrow-cells-and-bypass-grafting-for-regeneration-of-ischaemic-myocardium-the-cardio133-trial
#3
RANDOMIZED CONTROLLED TRIAL
Boris A Nasseri, Wolfram Ebell, Michael Dandel, Marian Kukucka, Rolf Gebker, Adelina Doltra, Christoph Knosalla, Yeong-Hoon Choi, Roland Hetzer, Christof Stamm
AIMS: Intra-myocardial transplantation of CD133(+) bone marrow stem cells (BMC) yielded promising results in clinical pilot trials. We now performed the double-blinded, randomized, placebo-controlled CARDIO133 trial to determine its impact on left ventricular (LV) function and clinical symptoms. METHODS AND RESULTS: Sixty patients with chronic ischaemic heart disease and impaired LV function (left ventricular ejection fraction, LVEF <35%) were randomized to undergo either coronary artery bypass grafting (CABG) and injection of CD133(+) BMC in the non-transmural, hypokinetic infarct border zone (CD133), or CABG and placebo injection (placebo)...
May 14, 2014: European Heart Journal
https://www.readbyqxmd.com/read/24358136/myocardial-scar-identified-by-magnetic-resonance-imaging-can-predict-left-ventricular-functional-improvement-after-coronary-artery-bypass-grafting
#4
Tao Yang, Min-Jie Lu, Han-Song Sun, Yue Tang, Shi-Wei Pan, Shi-Hua Zhao
BACKGROUND: Previous studies have shown that viable myocardium predicts recovery of left ventricular (LV) dysfunction after revascularization. Our aim was to evaluate the prognostic value of myocardial scar assessed by late gadolinium-enhanced cardiovascular magnetic resonance imaging (LGE-CMR) on functional recovery in patients undergoing coronary artery bypass grafting (CABG). METHODS: From November 2009 to September 2012, 63 patients with reduced left ventricular ejection fraction (LVEF) referred for first-time isolated CABG were prospectively enrolled, 52 were included in final analysis...
2013: PloS One
https://www.readbyqxmd.com/read/23478196/a-pilot-trial-of-autologous-bone-marrow-mononuclear-cell-transplantation-through-grafting-artery-a-sub-study-focused-on-segmental-left-ventricular-function-recovery-and-scar-reduction
#5
RANDOMIZED CONTROLLED TRIAL
Minjie Lu, Sheng Liu, Zhe Zheng, Gang Yin, Lei Song, Huaibing Chen, Xiuyu Chen, Qiyin Chen, Shiliang Jiang, Liangxin Tian, Zuoxiang He, Shengshou Hu, Shihua Zhao
BACKGROUND: Our preliminary study suggested that patients with chronic myocardial infarction (MI) and heart failure could potentially benefit from CABG combined with aBM-MNC by improving global left ventricular (LV) function. The purpose of this sub-study was to quantitatively evaluate the effectiveness of aBM-MNC transplantation during CABG in patients with chronic MI by intensively analyzing the global and segmental LV function, the scar, and the relationships between the function recovery and the scar transmural extent...
October 3, 2013: International Journal of Cardiology
https://www.readbyqxmd.com/read/23074393/positron-emission-tomography-for-the-assessment-of-myocardial-viability-an-evidence-based-analysis
#6
(no author information available yet)
UNLABELLED: In July 2009, the Medical Advisory Secretariat (MAS) began work on Non-Invasive Cardiac Imaging Technologies for the Assessment of Myocardial Viability, an evidence-based review of the literature surrounding different cardiac imaging modalities to ensure that appropriate technologies are accessed by patients undergoing viability assessment. This project came about when the Health Services Branch at the Ministry of Health and Long-Term Care asked MAS to provide an evidentiary platform on effectiveness and cost-effectiveness of non-invasive cardiac imaging modalities...
2010: Ontario Health Technology Assessment Series
https://www.readbyqxmd.com/read/23074392/magnetic-resonance-imaging-mri-for-the-assessment-of-myocardial-viability-an-evidence-based-analysis
#7
(no author information available yet)
UNLABELLED: In July 2009, the Medical Advisory Secretariat (MAS) began work on Non-Invasive Cardiac Imaging Technologies for the Assessment of Myocardial Viability, an evidence-based review of the literature surrounding different cardiac imaging modalities to ensure that appropriate technologies are accessed by patients undergoing viability assessment. This project came about when the Health Services Branch at the Ministry of Health and Long-Term Care asked MAS to provide an evidentiary platform on effectiveness and cost-effectiveness of noninvasive cardiac imaging modalities...
2010: Ontario Health Technology Assessment Series
https://www.readbyqxmd.com/read/20929540/prediction-of-global-left-ventricular-functional-recovery-in-patients-with-heart-failure-undergoing-surgical-revascularisation-based-on-late-gadolinium-enhancement-cardiovascular-magnetic-resonance
#8
Tammy J Pegg, Joseph B Selvanayagam, Joslin Jennifer, Jane M Francis, Theodoros D Karamitsos, Erica Dall'Armellina, Karen L Smith, David P Taggart, Stefan Neubauer
BACKGROUND: The new gold standard for myocardial viability assessment is late gadolinium enhancement-cardiovascular magnetic resonance (LGE-CMR); this technique has demonstrated that the transmural extent of scar predicts segmental functional recovery. We now asked how the number of viable and number of viable+normal, segments predicted recovery of global left ventricular (LV) function in patients undergoing CABG. Finally, we examined which segmental transmural threshold of scarring best predicted global LV recovery...
October 7, 2010: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/12947375/nonstress-delayed-enhancement-magnetic-resonance-imaging-of-the-myocardium-predicts-improvement-of-function-after-revascularization-for-chronic-ischemic-heart-disease-with-left-ventricular-dysfunction
#9
Paulo R Schvartzman, Monvadi B Srichai, Richard A Grimm, Nancy A Obuchowski, Donald F Hammer, Patrick M McCarthy, Jane M Kasper, Richard D White
BACKGROUND: The extent of myocardial scarring of the left ventricle (LV) is important in patients with chronic ischemic heart disease (CIHD). With delayed-enhancement magnetic resonance imaging (DE-MRI), scarred myocardium (hyper-enhanced) is easily distinguishable from viable (dark) myocardium. This investigation assessed the use of DE-MRI for predicting functional improvement after coronary artery bypass grafting (CABG) in patients with CIHD and significant LV dysfunction. METHODS: The patient population (n = 29) with CIHD and LV dysfunction (ejection fraction 28% +/- 10%) underwent both DE-MRI, to delineate scarred regions before revascularization, and echocardiography (Echo), to assess segmental function before and after CABG (interval 188 +/- 57 days)...
September 2003: American Heart Journal
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