keyword
MENU ▼
Read by QxMD icon Read
search

AMPA receptor

keyword
https://www.readbyqxmd.com/read/28535410/effect-of-enzyme-inhibition-on-perampanel-pharmacokinetics-why-study-design-matters
#1
Barry E Gidal, Rama Maganti, Antonio Laurenza, Haichen Yang, David A Verbel, Edgar Schuck, Jim Ferry
OBJECTIVES: Perampanel, a selective, noncompetitive AMPA receptor antagonist, is indicated as adjunctive therapy for the treatment of partial seizures with or without secondarily generalized seizures and primary generalized tonic-clonic seizures in patients with epilepsy aged 12years and older. In vitro studies and Phase I trials indicate that perampanel is metabolized almost exclusively by CYP3A, with an elimination half-life (t1/2) averaging approximately 105h. Understanding of pharmacokinetic (PK) interactions-enzyme inhibition or induction-and anticipating their occurrence are important for management of patients with epilepsy...
April 26, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28528135/presymptomatically-applied-ampa-receptor-antagonist-prevents-calcium-increase-in-vulnerable-type-of-motor-axon-terminals-of-mice-modeling-amyotrophic-lateral-sclerosis
#2
Roland Patai, Melinda Paizs, Massimo Tortarolo, Caterina Bendotti, Izabella Obál, József I Engelhardt, László Siklós
Increased intracellular calcium (Ca), which might be the consequence of an excess influx through Ca-permeable α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, plays a crucial role in degeneration of motor neurons. Previously we demonstrated that the presymptomatic application of AMPA receptor antagonist, talampanel, could reduce Ca elevation in spinal motor neurons of mice carrying the G93A mutation of superoxide dismutase 1 (SOD1), modeling amyotrophic lateral sclerosis (ALS). It remained to be examined whether the remote, functionally semi-autonomous motor axon terminals could be rescued from the Ca overload, or if the terminals, where the degeneration possibly starts, already experience intractable changes at early time points...
May 17, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28526611/alcohol-induces-input-specific-aberrant-synaptic-plasticity-in-the-rat-dorsomedial-striatum
#3
Tengfei Ma, Britton Barbee, Xuehua Wang, Jun Wang
Accumulated evidence suggests that the dorsomedial striatum (DMS) of the basal ganglia plays an essential role in pathological excessive alcohol consumption. The DMS receives multiple glutamatergic inputs. However, whether and how alcohol consumption distinctly affects these excitatory afferents to the DMS remains unknown. Here, we used optogenetics to selectively activate the rat medial prefrontal cortex (mPFC) and basolateral amygdala (BLA) inputs in DMS slices, and measured the effects of alcohol consumption on glutamatergic transmission in these corticostriatal and amygdalostriatal circuits...
May 16, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28522210/novel-trigeminal-slice-preparation-method-for-studying-mechanisms-of-nociception-transmission
#4
Mikiko Hirahara, Naoshi Fujiwara, Kenji Seo
BACKGROUND: The trigeminal subnucleus caudalis (Vc) plays a critical role in transmission and modulation of nociceptive afferent inputs, and exhibits a similar layer construction to the spinal dorsal horn. However, afferent inputs enter the brainstem and project to a separately located nucleus. It has previously been difficult to record responses of the Vc to afferent fiber activation in a brainstem slice preparation. The aim of the present study was to establish a novel brainstem slice preparation method to study trigeminal nociceptive transmission mechanisms...
May 15, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28522077/treatment-of-restless-legs-syndrome-with-the-selective-ampa-receptor-antagonist-perampanel
#5
Diego Garcia-Borreguero, Irene Cano, Juan Jose Granizo
OBJECTIVES: Perampanel is a selective, noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA) antagonist that has been approved for the treatment of partial seizures. Here we report on the first open study evaluating its efficacy in idiopathic restless legs syndrome (RLS). METHODS: The study was designed as a prospective two-month open trial. Twenty-two previously untreated patients diagnosed with idiopathic RLS began treatment with 2 mg perampanel, which was increased to 4 mg at week four if clinically necessary...
June 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28521778/cortical-kainate-receptors-and-behavioral-anxiety
#6
REVIEW
Min Zhuo
The study of glutamatergic synapses mainly focuses on the memory-related hippocampus. Recent studies in the cortical areas such as the anterior cingulate cortex (ACC) show that excitatory synapses can undergo long-term plastic changes in adult animals. Long-term potentiation (LTP) of cortical synapses may play important roles in chronic pain and anxiety. In addition to NMDA and AMPA receptors, kainate (KA) receptors have been found to play roles in synaptic transmission, regulation and presynaptic forms of LTP...
May 18, 2017: Molecular Brain
https://www.readbyqxmd.com/read/28521126/structural-and-functional-architecture-of-ampa-type-glutamate-receptors-and-their-auxiliary-proteins
#7
REVIEW
Ingo H Greger, Jake F Watson, Stuart G Cull-Candy
AMPA receptors (AMPARs) are tetrameric ion channels that together with other ionotropic glutamate receptors (iGluRs), the NMDA and kainate receptors, mediate a majority of excitatory neurotransmission in the central nervous system. Whereas NMDA receptors gate channels with slow kinetics, responsible primarily for generating long-term synaptic potentiation and depression, AMPARs are the main fast transduction elements at synapses and are critical for the expression of plasticity. The kinetic and conductance properties of AMPARs are laid down during their biogenesis and are regulated by post-transcriptional RNA editing, splice variation, post-translational modification, and subunit composition...
May 17, 2017: Neuron
https://www.readbyqxmd.com/read/28515681/the-activity-induced-long-non-coding-rna-meg3-modulates-ampa-receptor-surface-expression-in-primary-cortical-neurons
#8
Men C Tan, Jocelyn Widagdo, Yu Q Chau, Tianyi Zhu, Justin J-L Wong, Allen Cheung, Victor Anggono
Transcription of new RNA is crucial for maintaining synaptic plasticity, learning and memory. Although the importance of synaptic plasticity-related messenger RNAs (mRNAs) is well established, the role of a large group of long non-coding RNAs (lncRNAs) in long-term potentiation (LTP) is not known. In this study, we demonstrated the expression of a lncRNA cluster, namely maternally expressed gene 3 (Meg3), retrotransposon-like gene 1-anti-sense (Rtl1-AS), Meg8 and Meg9, which is located in the maternally imprinted Dlk1-Dio3 region on mouse chromosome 12qF1, in primary cortical neurons following glycine stimulation in an N-Methyl-D-aspartate receptor (NMDAR)-dependent manner...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28511603/clinical-experience-with-perampanel-for-refractory-pediatric-epilepsy-in-one-canadian-center
#9
Anita N Datta, Qi Xu, Shafina Sachedina, Cyrus Boelman, Linda Huh, Mary B Connolly
Perampanel (PER) is a new antiseizure medication that inhibits the α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) class of glutamate receptors. It is important for physicians to be aware of the efficacy and tolerability of new drugs in the postmarketing phase. We performed a retrospective review of our experience with perampanel at BC Children's Hospital. Twenty-four pediatric patients prescribed perampanel from 2014 to 2016 were identified. Fifteen (63%) discontinued perampanel, and 10 (42%) had greater than 50% reduction in seizures...
January 1, 2017: Journal of Child Neurology
https://www.readbyqxmd.com/read/28507080/divergent-roles-of-a-peripheral-transmembrane-segment-in-ampa-and-nmda-receptors
#10
Johansen B Amin, Catherine L Salussolia, Kelvin Chan, Michael C Regan, Jian Dai, Huan-Xiang Zhou, Hiro Furukawa, Mark E Bowen, Lonnie P Wollmuth
Ionotropic glutamate receptors (iGluRs), including AMPA receptor (AMPAR) and NMDA receptor (NMDAR) subtypes, are ligand-gated ion channels that mediate signaling at the majority of excitatory synapses in the nervous system. The iGluR pore domain is structurally and evolutionarily related to an inverted two-transmembrane K(+) channel. Peripheral to the pore domain in eukaryotic iGluRs is an additional transmembrane helix, the M4 segment, which interacts with the pore domain of a neighboring subunit. In AMPARs, the integrity of the alignment of a specific face of M4 with the adjacent pore domain is essential for receptor oligomerization...
May 15, 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/28501494/focused-microwave-irradiation-assisted-immunohistochemistry-to-study-effects-of-ketamine-on-phospho-erk-expression-in-the-mouse-brain
#11
Alda Fernandes, Yu-Wen Li
Ketamine produces rapid and long-lasting antidepressant effects in depressive patients. Preclinical studies demonstrate that ketamine stimulates AMPA receptor transmission and activates BDNF/TrkB-Akt/ERK-mTOR signaling cascades, leading to a sustained increase in synaptic protein synthesis and strengthening of synaptic plasticity, a potential mechanism underlying the antidepressant effects. The purpose of this study was to develop an immunohistochemistry (IHC) assay to map the distribution of extracellular signal-regulated kinase (ERK) phosphorylation in the mouse brain in response to systemic ketamine treatment...
May 10, 2017: Brain Research
https://www.readbyqxmd.com/read/28500623/simultaneous-inhibition-of-nmda-and-mglu1-5-receptors-by-levo-corydalmine-in-rat-spinal-cord-attenuates-bone-cancer-pain
#12
Wen-Ling Dai, Bing Yan, Nan Jiang, Juan-Juan Wu, Xiu-Feng Liu, Ji-Hua Liu, Bo-Yang Yu
Bone cancer pain is a challenge for its not completely clarified mechanism and broad clinical morbidity. Therefore, novel and more effective drugs are urgent needed for improvement of patients' quality of life. Glutamate receptors have been associated with the development of the central sensitization of chronic pain. Inhibition of N-methyl-D-aspartate (NMDA) and metabotropic glutamate (mGlu) receptors can effectively attenuate bone cancer pain respectively. Herein, our results indicated that levo-Corydalmine (l-CDL), a compound from Corydalis yanhusuo W...
May 13, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28498410/neuropeptide-y-suppresses-epileptiform-discharges-by-regulating-ampa-receptor-glur2-subunit-in-rat-hippocampal-neurons
#13
Wei Bu, Wen-Qing Zhao, Wen-Ling Li, Chang-Zheng Dong, Zhe Zhang, Qi-Jun Li
The present study aimed to investigate the effects of neuropeptide Y (NPY) on the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor glutamate receptor 2 (GluR2) subunit in epileptiform discharge hippocampal neurons. Hippocampal neurons were harvested from neonatal Sprague‑Dawley rats aged <24 h and primarily cultured in vitro. At day 12 following culture, hippocampal neurons were divided into the following groups: Control, Mg2+‑free, NPY+Mg2+‑free and BIBP3226+NPY+Mg2+‑free...
May 10, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28495973/contrasting-the-role-of-xct-and-glt-1-upregulation-in-the-ability-of-ceftriaxone-to-attenuate-the-cue-induced-reinstatement-of-cocaine-seeking-and-normalize-ampa-receptor-subunit-expression
#14
Amber L Lacrosse, Sinead M O'Donovan, Marian T Sepulveda-Orengo, Robert E McCullumsmith, Kathryn J Reissner, Marek Schwendt, Lori A Knackstedt
Chronic treatment with ceftriaxone attenuates reinstatement of cocaine-seeking while increasing the function of the glutamate transporter GLT-1 and system xC- (Sxc) in the nucleus accumbens core (NAc). Sxc contributes the majority of non-synaptic extracellular glutamate in the NAc, while GLT-1 is responsible for the majority of glutamate uptake. Here we used antisense to decrease the expression of GLT-1 and xCT (catalytic subunit of Sxc), in order to determine the relative importance of both proteins in mediating ceftriaxone's ability to prevent cue-induced reinstatement of cocaine-seeking and normalize glutamatergic proteins in the NAc of rats...
May 11, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28495313/posterior-hypothalamus-glutamate-infusion-decreases-pentylenetetrazol-induced-seizures-of-male-rats-through-hippocampal-histamine-increase
#15
A Arzhang, M Elahdadi Salmani, T Lashkarbolouki, I Goudarzi
OBJECTIVES: Seizures are epileptic manifestations that are intrinsically modulated through different neurotransmitters and receptor systems. Although glutamate increases excitation and hence seizures, it activates other systems which could potentially terminate seizures. Histamine originates from neurons of the posterior hypothalamus (PH) and can mediate anticonvulsant properties, but the effect of local PH glutamate on hippocampal histamine content is unknown. Therefore, in this study, the effect of PH glutamate and the involvement of hippocampal histamine in pentylenetetrazol (PTZ) induced seizure activity was studied...
May 8, 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/28492978/seizure-response-to-perampanel-in-drug-resistant-epilepsy-with-gliomas-early-observations
#16
Charles Vecht, Alberto Duran-Peña, Caroline Houillier, Thomas Durand, Laurent Capelle, Gilles Huberfeld
Drug-resistant epilepsy (DRE) occurs commonly in gliomas, possibly due to a shared mechanism of AMPA-activation involving both seizure activity and tumor growth. We tested the AMPA-receptor blocker perampanel (PER) in patients with DRE in low- and high-grade gliomas. Seizure response was defined as 50% drop in seizure frequency or as seizure-freedom. Cognitive function was examined by computerized test on cognitive speed (CTCS), which is sensitive to the type of cognitive dysfunction associated with epilepsy and use of anticonvulsants...
May 10, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28487223/obesogenic-diet-intake-during-pregnancy-programs-aberrant-synaptic-plasticity-and-addiction-like-behavior-to-a-palatable-food-in-offspring
#17
Alberto Camacho, Larisa Montalvo-Martinez, Robbi E Cardenas-Perez, Lizeth Fuentes-Mera, Lourdes Garza-Ocañas
Contextual food conditioned behaviors require plasticity of glutamatergic neurotransmission in the reward system, involving changes in the expression of including a-amino-3-hydroxy-5- methylisoxazole-4-propionate receptors (AMPA), N-methyl-d-aspartic acid (NMDA) and metabotropic glutamate 2,3 (mGlur 2,3). However, the role of changes in glutamatergic synaptic markers on energy-dense palatable food preference during development has not been described. Here, we determine the effect of nutritional programing during gestation on fat food choices using a conditioned place preference (CPP) test and an operant training response and its effect on glutamatergic markers in the nucleus accumbens (Nac) shell and prefrontal cortex (PFC)...
May 6, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28483674/the-postnatal-5-ht1a-receptor-regulates-adult-anxiety-and-depression-differently-via-multiple-molecules
#18
Chihiro Ishikawa, Takashi Shiga
Serotonin (5-HT) and the 5-HT1A receptor during development are known to modulate anxiety and depression in later life. However, the brain mechanisms linking the postnatal 5-HT system and adult behavior remain unknown. Here, we examined the effects of pharmacological 5-HT1A receptor activation during the postnatal period on anxiety and depression-like behavior in adult BALB/c male mice. To elucidate the underlying mechanisms, we measured mRNA expression of the 5-HT1A receptor, brain-derived neurotrophic factor (BDNF), GABAA receptor subunits, and AMPA receptor subunits in the medial prefrontal cortex (mPFC), amygdala, and hippocampus...
May 5, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28479397/locomotor-sensitization-to-intermittent-ketamine-administration-is-associated-with-nucleus-accumbens-plasticity-in-male-and-female-rats
#19
C E Strong, K J Schoepfer, A M Dossat, S K Saland, K N Wright, M Kabbaj
Clinical evidence suggests superior antidepressant response over time with a repeated, intermittent ketamine treatment regimen as compared to a single infusion. However, the club drug ketamine is commonly abused. Therefore, the abuse potential of repeated ketamine injections at low doses needs to be investigated. In this study, we investigated the abuse potential of repeated exposure to either 0, 2.5, or 5 mg/kg ketamine administered once weekly for seven weeks. Locomotor activity and conditioned place preference (CPP) were assayed to evaluate behavioral sensitization to the locomotor activating effects of ketamine and its rewarding properties, respectively...
May 4, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28474392/detection-and-characterization-of-individual-endocytosis-of-ampa-type-glutamate-receptor-around-postsynaptic-membrane
#20
Shumpei Fujii, Hiromitsu Tanaka, Tomoo Hirano
Synaptic plasticity such as long-term depression (LTD) has been regarded as a cellular mechanism of learning and memory. LTD is expressed by the decrease in number of postsynaptic AMPA-type receptor (AMPAR) at glutamatergic synapses. Although endocytosis is known to play an essential role in the decrease in AMPAR on postsynaptic membrane, the difficulty to detect individual endocytic events hampered clarification of AMPAR dynamics around synapses. Previously, we developed a method to induce formation of postsynaptic-like membrane (PSLM) on the glass surface and observed pHluorin-tagged AMPAR around PSLM with total internal reflection fluorescence microscopy...
May 5, 2017: Genes to Cells: Devoted to Molecular & Cellular Mechanisms
keyword
keyword
57547
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"