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multi-drug resistant bacteria

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https://www.readbyqxmd.com/read/27920884/novel-combinations-of-synthesized-zno-nps-and-ceftazidime-evaluation-of-their-activity-against-standards-and-new-clinically-isolated-pseudomonas-aeruginosa
#1
Elham Isaei, Shahla Mansouri, Fereshteh Mohammadi, Sadegh Taheritarigh, Zohreh Mohammadi
BACKGROUND: Antibiotic resistant bacteria can be considered as a main problem in infection management. Zinc oxide nanoparticles (ZnO NPs), individually or in combination with antibiotics, can be considered as good candidates for struggling against drug resistant bacteria. METHODS: In this study, Zinc oxide nanoparticles were synthesized using sol-gel method in low temperature as a cost effective procedure and characterized by X-ray diffraction and Scanning Electron Microscopy...
October 2016: Avicenna Journal of Medical Biotechnology
https://www.readbyqxmd.com/read/27917795/lytic-activity-of-various-phage-cocktails-on-multidrug-resistant-bacteria
#2
I Ozkan, E Akturk, N Yeshenkulov, S Atmaca, N Rahmanov, H I Atabay
PURPOSE: A bacteriophage is a virus that infects and replicates within a bacterium following the injection of phage genome into the bacterial cytoplasm. They are seen as a possible therapy for multi-drug-resistant strains of many bacteria. The aim of this study is to evaluate the lytic activity of the Pyo, Intesti and Fersisi bacteriophage cocktails on P. aeruginosa and S. aureus. METHODS: Ten different S. aureus and P. aeruginosa strains, which were isolated from hospitalized patients in Turkey, were used in the study...
December 1, 2016: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://www.readbyqxmd.com/read/27917206/anticancer-and-antibacterial-secondary-metabolites-from-the-endophytic-fungus-penicillium-sp-cam64-against-multi-drug-resistant-gram-negative-bacteria
#3
Jean-Bosco Jouda, Jean-de-Dieu Tamokou, Céline Djama Mbazoa, Prodipta Sarkar, Prasanta Kumar Bag, Jean Wandji
BACKGROUND: The emergence of multiple-drug resistance bacteria has become a major threat and thus calls for an urgent need to search for new effective and safe anti-bacterial agents. OBJECTIVES: This study aims to evaluate the anticancer and antibacterial activities of secondary metabolites from Penicillium sp., an endophytic fungus associated with leaves of Garcinia nobilis. METHODS: The culture filtrate from the fermentation of Penicillium sp...
September 2016: African Health Sciences
https://www.readbyqxmd.com/read/27913311/should-travelers-be-screened-for-multi-drug-resistant-mdr-bacteria-after-visiting-high-risk-areas-such-as-india
#4
Eskild Petersen, Jalila Mohsin
No abstract text is available yet for this article.
November 29, 2016: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/27909433/sponge-microbiota-are-a-reservoir-of-functional-antibiotic-resistance-genes
#5
Dennis Versluis, Mari Rodriguez de Evgrafov, Morten O A Sommer, Detmer Sipkema, Hauke Smidt, Mark W J van Passel
Wide application of antibiotics has contributed to the evolution of multi-drug resistant human pathogens, resulting in poorer treatment outcomes for infections. In the marine environment, seawater samples have been investigated as a resistance reservoir; however, no studies have methodically examined sponges as a reservoir of antibiotic resistance. Sponges could be important in this respect because they often contain diverse microbial communities that have the capacity to produce bioactive metabolites. Here, we applied functional metagenomics to study the presence and diversity of functional resistance genes in the sponges Aplysina aerophoba, Petrosia ficiformis, and Corticium candelabrum...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27902427/phenotypic-and-genetic-characterization-of-multi-drug-resistant-staphylococcus-aureus-in-the-tropics-of-southeast-asia
#6
Siti Norayuni Mohd Zulkeflle, Yus Amira Yusaimi, Norio Sugiura, Koji Iwamoto, Masafumi Goto, Motoo Utsumi, Nor'azizi Bin Othman, Zuriati Zakaria, Hirofumi Hara
Antibiotic resistance has become a major public health problem throughout the world. The presence of antibiotic resistant bacteria such as Staphylococcus aureus (S. aureus) and antibiotic resistance genes (ARGs) in hospital wastewater is cause for great concern today. In this study, 276 S. aureus isolates were recovered from hospital wastewater samples in Malaysia. All of the isolates were screened for susceptibility to nine different classes of antibiotics: ampicillin (AMP), ciprofloxacin (CFX), gentamicin (GMN), kanamycin (KMN), erythromycin (ERM), vancomycin (VAN), trimetoprim and sulfamethaxazole (TM-SMZ), chloramphenicol (CMP), tetracycline (TET), and nalidixic acid (NAL)...
November 3, 2016: Microbiology
https://www.readbyqxmd.com/read/27894288/bactericidal-and-antioxidant-properties-of-essential-oils-from-the-fruits-dennettia-tripetala-g-baker
#7
Sunday O Okoh, Benson C Iweriegbor, Omobola O Okoh, Uchechukwu U Nwodo, Anthony I Okoh
BACKGROUND: The antibacterial and antioxidant properties of the essential oils (EOs) of unripe and ripe fruits of Dennettia tripetala and their potential for the management of infectious and oxidative-stress diseases were investigated in-vitro in this study. METHOD: Essential oil obtained from the fruit in Clevenger modified apparatus, was characterized by high resolution GC-MS, while antioxidant and antibacterial properties were tested by spectrophotometric and agar diffusion methods respectively...
November 28, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27890360/anti-tubercular-peptides-a-quest-of-future-therapeutic-weapon-to-combat-tuberculosis
#8
REVIEW
Ameer Khusro, Chirom Aarti, Paul Agastian
Tuberculosis (TB) is a symbolic menace to mankind, infecting almost one third of the world's populace and causing over a million mortalities annually. Mycobacterium tuberculosis (Mtb) is the key pathogen of TB that invades and replicates inside the host's macrophage. With the emerging dilemma of multi-drug resistant tuberculosis (MDR-TB) and extensively-drug resistant tuberculosis (XDR-TB), the exigency for developing new TB drugs is an obligation now for worldwide researchers. Among the propitious antimycobacterial agents examined in last few decades, anti-tubercular peptides have been substantiated to be persuasive with multiple advantages such as low immunogenicity, selective affinity to bacterial negatively charged cell envelopes and most importantly divergent mechanisms of action...
November 2016: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/27885285/emergence-of-aminoglycoside-resistance-due-to-arma-methylase-in-multi-drug-resistant-acinetobacter-baumannii-isolates-in-a-university-hospital-in-nepal
#9
S Shrestha, T Tada, B Shrestha, T Kirikae, H Ohara, B P Rijal, B M Pokhrel, J B Sherchand
BACKGROUND: The emergence of multidrug-resistant Acinetobacter baumannii associated with hospital-acquired infections has been increasingly reported worldwide. 16S rRNA methylase producing Gram-negative bacteria are highly resistant to all clinically important aminoglycosides. We analyzed A. baumannii clinical isolates resistant to aminoglycosides from hospitalized patients. The objective of this study was to investigate the emergence of armA in A.baumannii species associated with nosocomial infection in a university hospital in Nepal...
May 2016: Journal of Nepal Health Research Council
https://www.readbyqxmd.com/read/27873243/antibiotics-precious-goods-in-changing-times
#10
Peter Sass
Antibiotics represent a first line of defense of diverse microorganisms, which produce and use antibiotics to counteract natural enemies or competitors for nutritional resources in their nearby environment. For antimicrobial activity, nature has invented a great variety of mechanisms of antibiotic action that involve the perturbation of essential bacterial structures or biosynthesis pathways of macromolecules such as the bacterial cell wall, DNA, RNA, or proteins, thereby threatening the specific microbial lifestyle and eventually even survival...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27862971/structural-snapshots-of-the-%C3%AE-barrel-assembly-machinery
#11
REVIEW
Jeremy Bakelar, Susan K Buchanan, Nicholas Noinaj
The β-barrel assembly machinery (BAM) is a multi-component complex responsible for the biogenesis of β-barrel outer membrane proteins (OMPs) in Gram-negative bacteria, with conserved systems in both mitochondria and chloroplasts. Given its importance in the integrity of the outer membrane and in the assembly of surface exposed virulence factors, BAM is an attractive therapeutic target against pathogenic bacteria, particularly multi-drug resistant strains. While the mechanism for how BAM functions remains elusive, previous structural studies have described each of the individual components of BAM, offering only a few clues to how the complex functions...
November 14, 2016: FEBS Journal
https://www.readbyqxmd.com/read/27842536/antibacterial-and-cytotoxic-cytochalasins-from-the-endophytic-fungus-phomopsis-sp-harbored-in-garcinia-kola-heckel-nut
#12
Jean-Bosco Jouda, Jean-de-Dieu Tamokou, Céline Djama Mbazoa, Clovis Douala-Meli, Prodipta Sarkar, Prasanta Kumar Bag, Jean Wandji
BACKGROUND: The continuous emergence of multidrug-resistant (MDR) bacteria drastically reduced the efficacy of our antibiotic armory and consequently, increased the frequency of therapeutic failure. The search for bioactive constituents from endophytic fungi against MDR bacteria became a necessity for alternative and promising strategies, and for the development of novel therapeutic solutions. We report here the isolation and structure elucidation of antibacterial and cytotoxic compounds from Phomopsis sp...
November 14, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27833601/synergistic-nisin-polymyxin-combinations-for-the-control-of-pseudomonas-biofilm-formation
#13
Des Field, Nynke Seisling, Paul D Cotter, R P Ross, Colin Hill
The emergence and dissemination of multi-drug resistant pathogens is a global concern. Moreover, even greater levels of resistance are conferred on bacteria when in the form of biofilms (i.e., complex, sessile communities of bacteria embedded in an organic polymer matrix). For decades, antimicrobial peptides have been hailed as a potential solution to the paucity of novel antibiotics, either as natural inhibitors that can be used alone or in formulations with synergistically acting antibiotics. Here, we evaluate the potential of the antimicrobial peptide nisin to increase the efficacy of the antibiotics polymyxin and colistin, with a particular focus on their application to prevent biofilm formation of Pseudomonas aeruginosa...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27815276/genome-dynamics-and-molecular-infection-epidemiology-of-multi-drug-resistant-helicobacter-pullorum-isolates-obtained-from-broiler-and-country-chickens-in-india
#14
Shamsul Qumar, Mohammad Majid, Narender Kumar, Sumeet K Tiwari, Torsten Semmler, Savita Devi, Ramani Baddam, Arif Hussain, Sabiha Shaik, Niyaz Ahmed
: Some of the life-threatening, foodborne, and zoonotic infections are transmitted through poultry birds. Inappropriate and indiscriminate use of antimicrobials in livestock industry has led to increased prevalence of multidrug resistant bacteria of epidemic potentials. Herein, we present the functional molecular epidemiological analysis entailing phenotypic as well as whole genome sequence based characterization of eleven H. pullorum isolates from broiler and free range chickens sampled from retail wet markets of Hyderabad city in India...
November 4, 2016: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/27805179/the-singular-behavior-of-a-%C3%AE-type-semi-synthetic-two-branched-polypeptide-three-dimensional-structure-and-mode-of-action
#15
Giorgia Manzo, Ilaria Serra, Alessandro Pira, Manuela Pintus, Matteo Ceccarelli, Mariano Casu, Andrea C Rinaldi, Mariano Andrea Scorciapino
Dendrimeric peptides make a versatile group of bioactive peptidomimetics and a potential new class of antimicrobial agents to tackle the pressing threat of multi-drug resistant pathogens. These are branched supramolecular assemblies where multiple copies of the bioactive unit are linked to a central core. Beyond their antimicrobial activity, dendrimeric peptides could also be designed to functionalize the surface of nanoparticles or materials for other medical uses. Despite these properties, however, little is known about the structure-function relationship of such compounds, which is key to unveil the fundamental physico-chemical parameters and design analogues with desired attributes...
November 16, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27782860/evaluation-of-therapeutic-potentials-of-plant-extracts-against-poultry-bacteria-threatening-public-health
#16
Moses Abiala, John Olayiwola, Oluwatoyin Babatunde, Olapeju Aiyelaagbe, Sunday Akinyemi
BACKGROUND: Plant extracts were evaluated on poultry bacteria known to be threatening public health. This is to develop better bio-therapeutic agents from plant origin. METHODS: Bacteria were isolated from water, feed, crop, gizzard and faeces of layer chicken. Isolates of interest (Escherichia coli, Salmonella enteritidis, Pseudomonas aeruginosa and Klebsiella oxytoca) were subjected to antibiotic susceptibility test. Resistant strains were further evaluated against different plant extracts in comparison to Meropenem (control) using agar diffusion method...
October 26, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27771149/esbl-producing-gram-negative-organisms-in-the-healthcare-environment-as-a-source-of-genetic-material-for-resistance-in-human-infections
#17
M Muzslay, G Moore, N Alhussaini, A P R Wilson
BACKGROUND: The increasing prevalence of extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae in the healthcare setting and in the community despite established infection control guidelines indicates that these microorganisms may possess survival strategies that allow them to persist in the environment. AIMS: To determine the extent and variation in endemic ESBL-carrying species in different ward environments, and to investigate the potential for cephalosporin resistance to be transferred from environmental isolates to human pathogens...
September 17, 2016: Journal of Hospital Infection
https://www.readbyqxmd.com/read/27769670/bis-n-amidinohydrazones-and-n-amidino-n-aryl-bishydrazones-new-classes-of-antibacterial-antifungal-agents
#18
Sanjib K Shrestha, Liliia M Kril, Keith D Green, Stefan Kwiatkowski, Vitaliy M Sviripa, Justin R Nickell, Linda P Dwoskin, David S Watt, Sylvie Garneau-Tsodikova
The emergence of multidrug-resistant bacterial and fungal strains poses a threat to human health that requires the design and synthesis of new classes of antimicrobial agents. We evaluated bis(N-amidinohydrazones) and N-(amidino)-N'-aryl-bishydrazones for their antibacterial and antifungal activities against panels of Gram-positive/Gram-negative bacteria as well as fungi. We investigated their potential to develop resistance against both bacteria and fungi by a multi-step resistance-selection method, explored their potential to induce the production of reactive oxygen species, and assessed their toxicity...
October 10, 2016: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/27768953/photodynamic-inactivation-of-methicillin-resistant-staphylococcus-aureus-and-escherichia-coli-a-metalloporphyrin-comparison
#19
Troy A Skwor, Stephanie Klemm, Hanyu Zhang, Brianna Schardt, Stephanie Blaszczyk, Matthew A Bork
Increasing rates of antibiotic resistance coupled with the lack of novel antibiotics threatens proper clinical treatment and jeopardizes their use in prevention. A photodynamic approach appears to be an innovative treatment option, even for multi-drug resistant strains of bacteria. Three components are utilized in photodynamic inactivation: a photosensitizer, light source, and oxygen. Variations in photosensitizers strongly influence microbial binding and bactericidal activity. In this study, four different cationic metalloporphyrins (Cu(2+), Fe(2+), Pd(2+), Zn(2+)) were compared to the free-base ligand 5,10,15,20-tetrakis(N-methylpyridinium-4-yl)porphyrin regarding their electronic properties and generation of reactive oxygen species upon subsequent 405nm violet-blue irradiation...
October 15, 2016: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/27765353/carnosic-acid-acts-synergistically-with-gentamicin-in-killing-methicillin-resistant-staphylococcus-aureus-clinical-isolates
#20
Nicolás M Vázquez, Graciela Fiorilli, Paulo A Cáceres Guido, Silvia Moreno
BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) is resistant to different commonly used antibiotics, stressing the need for further strategies to treat this human pathogen with worldwide prevalence. The use of phytochemicals within the current pharmacology is a promising approach to enhance the antimicrobial activity of common antibiotics in the battle against these bacteria. PURPOSE: The purpose of this study was to determine the antimicrobial effectiveness of carnosic acid, the major constituent of Rosmarinus officinalis L...
November 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
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