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multi-drug resistant bacteria

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https://www.readbyqxmd.com/read/29673980/photoactivated-2-3-distyrylindoles-kill-multi-drug-resistant-bacteria
#1
Leslie Edwards, Danielle Turner, Cody Champion, Megha Khandelwal, Kailee Zingler, Cassidy Stone, Ruwini D Rajapaksha, Jing Yang, Mahinda I Ranasinghe, Alexander Kornienko, Liliya V Frolova, Snezna Rogelj
Compounds based on the 2,3-distyrylindole scaffold were found to exhibit bactericidal properties upon irradiation with white light. At the concentration of 1 μM, the lead compound 1 completely (ca. 109  CFU/mL) eradicated such Gram-positive organisms as S. aureus (MRSA, MSSA), E. faecalis (VRE), S. pyogenes and S. mutans when irradiated with white light for 2 min. At the concentration of 5 μM and in the presence of polymyxin E at non-bactericidal 1.25 μg/mL concentration, 1 also showed a 7-log to 9-log reductions in bacterial counts of such Gram-negative organisms as multi-drug resistant (MDR) A...
April 3, 2018: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29671712/detection-of-multi-drug-resistant-escherichia-coli-in-a-giant-panda-ailuropoda-melanoleuca-with-extraintestinal-polyinfection
#2
Wei Zhou, Lingwei Zhu, Min Jia, Tiecheng Wang, Bing Liang, Xue Ji, Yang Sun, Jun Liu, Xuejun Guo
Multi-drug-resistant Escherichia coli, Pseudomonas aeruginosa, and Enterococcus faecalis were isolated from the tissue samples of a giant panda. The E. coli strain SH-YH-DH that we isolated carried a self-transferable plasmid associated with multi-drug-resistant genes ( blaCTX-M-55 , blaTEM-1 , sul1, floR, strB, aac(6')-Ib, and tetA/R). This strain exhibited phenotypic resistance to gentamicin, cefotaxime, ampicillin, chloramphenicol, trimethoprim-sulfamethoxazole, and tetracycline. We report the participation of multi-drug-resistant E...
April 19, 2018: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/29665885/prevalence-of-extended-spectrum-%C3%AE-lactamase-producing-escherichia-coli-and-residual-antimicrobials-in-the-environment-in-vietnam
#3
Shinji Yamasaki, Tuyen Danh Le, Mai Quang Vien, Chinh Van Dang, Yoshimasa Yamamoto
Emergence and spread of antimicrobial-resistant bacteria, including extended-spectrum β-lactamase (ESBL)-producing Escherichia coli, have become serious problems worldwide. Recent studies conducted in Vietnam revealed that ESBL-producing E. coli are widely distributed in food animals and people. CTX-M-9 and CTX-M-1 are the most prevalent β-lactamases among the identified ESBLs. Furthermore, most of the ESBL-producing E. coli isolates were multi-drug resistant. Residual antimicrobials such as sulfamethoxazole, trimethoprim, sulfadimidine, cephalexin, and sulfadiazine were also detected at a high level in both animal meats and environmental water collected from several cities, including Ho Chi Minh city and Can Tho city...
December 2017: Animal Health Research Reviews
https://www.readbyqxmd.com/read/29665443/activity-of-a-nitric-oxide-generating-wound-treatment-system-against-wound-pathogen-biofilms
#4
Richard D Waite, Joanne E Stewart, Abish S Stephen, Robert P Allaker
Wound bioburden plays an important role in impaired healing and the development of infection-related complications. The objective of this study was to determine the efficacy of an innovative two-layer nitric oxide generating system (NOx) to prevent and treat biofilms formed by bacterial and fungal pathogens commonly associated with wound infection, and activity against Pseudomonas aeruginosa virulence factors. Single and mixed species biofilms were grown for 24h on nitrocellulose filters placed on agar. Filters were covered with either NOx or placebo, before and after biofilm formation...
April 14, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29659796/dissemination-of-multi-resistant-gram-negative-bacteria-into-german-wastewater-and-surface-waters
#5
Heike Müller, Esther Sib, Mike Gajdiss, Ursula Klanke, Franziska Lenz-Plet, Vanessa Barabasch, Cathrin Albert, Anna Schallenberg, Christian Timm, Nicole Zacharias, Ricarda Maria Schmithausen, Steffen Engelhart, Martin Exner, Marijo Parcina, Christiane Schreiber, Gabriele Bierbaum
Carbapenem antibiotics constitute the mainstay therapy of nosocomial infections with ESBL (extended spectrum beta-lactamase) producing Gram-negative bacteria, however, resistance against these compounds is increasing. This study was designed to demonstrate that carbapenemase-producing bacteria are disseminated from hospitals into the environment. To this end, resistant bacteria were isolated from a clinical/urban and from a rural catchment system in Germany in 2016/17. The study followed the dissemination of resistant bacteria from the wastewater through the wastewater treatment plant into the receiving surface waters...
April 6, 2018: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/29656216/insights-into-cell-penetrating-peptide-conjugated-gold-nanoparticles-for-internalization-into-bacterial-cells
#6
Munish Kumar, Werner Tegge, Nishima Wangoo, Rahul Jain, Rohit K Sharma
Gold nanoparticles (AuNPs) functionalized with different biomolecules find extensive application in therapy, clinical diagnosis and biomedical imaging. Herein, two derivatives of TAT peptide with sequences YGRKKRRQRRR and YGRKKRRQRRR-(β-ala)3 -Cys-amide were conjugated with tannic acid capped gold nanoparticles which acted as a carrier for cell penetrating peptides (CPPs) into the bacterial cells. The interaction of YGRKKRRQRRR peptide with AuNPs was non-covalent in nature whereas YGRKKRRQRRR-(β-ala)3 -Cys-amide interacted covalently with the AuNPs due to presence of thiol group in cysteine which bind strongly to gold nanoparticles surface...
March 31, 2018: Biophysical Chemistry
https://www.readbyqxmd.com/read/29625989/a-cell-penetrating-peptide-fused-phage-lysin-kills-intracellular-mrsa-in-keratinocytes-and-treatment-for-skin-infections-of-mice
#7
ZhaoFei Wang, LiCheng Kong, Yang Liu, Qiang Fu, ZeLin Cui, Jian Wang, JingJiao Ma, HengAn Wang, YaXian Yan, JianHe Sun
Staphylococcus aureus ( S. aureus ) is the major pathogen that causes skin and skin structure infections, which is able to survive and persist in keratinocytes of the epidermis. Since the evolution of multi-drug resistant bacteria, the use of phages and their lysins presents a promising alternative approach. In this study, a cell wall hydrolase (also called lysin) derived from Staphylococcus phage JD007, short for JDlys, was identified. The JDlys showed a strong lytic activity against MRSA strains from different sources and multilocus sequence typing (MLST) types...
April 6, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29618862/acetic-acid-dressings-finding-the-holy-grail-for-infected-wound-management
#8
Kapil S Agrawal, Anup Vidyadhar Sarda, Raghav Shrotriya, Manoj Bachhav, Vinita Puri, Gita Nataraj
Background: Wounds have since long, contributed majorly to the health-care burden. Infected long-standing non-healing wounds place many demands on the treating surgeon and are devastating for the patients physically, nutritionally, vocationally, financially, psychologically and socially. Acetic acid has long been included among agents used in the treatment of infected wounds. In this study, we have evaluated the use of acetic acid for topical application in the treatment of infected wounds...
September 2017: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/29618511/structural-and-functional-delineation-of-aerobactin-biosynthesis-in-hypervirulent-klebsiella-pneumoniae
#9
Daniel C Bailey, Evan Alexander, Matthew R Rice, Eric J Drake, Lisa S Mydy, Courtney C Aldrich, Andrew M Gulick
Aerobactin, a citryl-hydroxamate siderophore, is produced by a number of pathogenic Gram-negative bacteria to aid in iron assimilation. Interest in this well-known siderophore was reignited by recent investigations suggesting that it plays a key role in mediating the enhanced virulence of a hypervirulent pathotype of Klebsiella pneumoniae (hvKP). In contrast to classical opportunistic strains of Klebsiella pneumoniae, hvKP causes serious life-threatening infections in previously healthy individuals in the community...
April 4, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29618453/report-susceptibility-of-avian-pathogenic-escherichia-coli-from-zoo-birds-in-indonesia-to-antibiotics-and-disinfectants
#10
Sajid Umar, Ana Triana Maiyah, Mehwish Shareef, Hajra Qadir, Qamarun Nisa, Seema Abbas
Antibiotic resistance in avian pathogenic Escherichia coli (APEC) is a common problem in the Indonesian poultry industry. Zoo birds have been postulated as sentinels, reservoirs, and potential spreaders of antibiotic resistance, although much is still unknown about the strains of zoo birds. Disinfection can reduce the infection burden. However, little is known about the presence of resistance against these products. Sixty one APEC strains were isolated from Indonesian zoo birds. The resistance to different classes of antibiotics as well as the minimum inhibitory concentrations (MIC) and minimum bactericidal concentrations (MBC) of five disinfectants most often used in the poultry industry was determined...
March 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29608117/clinical-impact-of-rapid-bacterial-identification-by-maldi-tof-ms-combined-with-the-b%C3%A3%C2%AAta-lacta%C3%A2-test-on-early-antibiotic-adaptation-by-an-antimicrobial-stewardship-team-in-bloodstream-infections
#11
A Mizrahi, J Amzalag, C Couzigou, G Péan De Ponfilly, B Pilmis, A Le Monnier
BACKGROUND: Bloodstream infections (BSI) can potentially be life-threatening infections and are associated with a high crude mortality, moreover with an inappropriate first-line antibiotic therapy. Bacterial resistance is more and more frequently observed. New strategies of BSI management are urgently needed. MATERIALS AND METHODS: During an 18-months period, we prospectively evaluated the clinical impact of rapid bacterial identification by MALDI-TOF MS technology combined with an antimicrobial stewardship team (AST) intervention...
April 2, 2018: Infectious Diseases
https://www.readbyqxmd.com/read/29596745/imidazopyrazinones-ipys-non-quinolone-bacterial-topoisomerase-inhibitors-showing-partial-cross-resistance-with-quinolones
#12
Frédéric Jeannot, Thomas Taillier, Pierre Despeyroux, Stephane Renard, Astrid Rey, Michaël Mourez, Christoph Poeverlein, Imène Khichane, Marc-Antoine Perrin, Stéphanie Versluys, Robert A Stavenger, Jianzhong Huang, Thomas Germe, Anthony Maxwell, Sha Cao, Douglas L Huseby, Diarmaid Hughes, Eric Bacqué
In our quest for new antibiotics able to address the growing threat of multi-drug resistant infections caused by Gram-negative bacteria, we have investigated an unprecedented series of non-quinolone bacterial topoisomerase inhibitors from the Sanofi patrimony, named IPYs for ImidazoPYrazinones as part of the IMI ENABLE organization. Hybridization of these historical compounds with the quinazolinediones, a known series of topoisomerase inhibitors, led us to a novel series of tricyclic IPYs that demonstrated potential for broad spectrum activity, in vivo efficacy and a good developability profile although later profiling revealed a genotoxicity risk...
March 29, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29595093/synergy-of-clavine-alkaloid-chanoclavine-with-tetracycline-against-multi-drug-resistant-e-coli
#13
Gaurav Raj Dwivedi, Anupam Maurya, Dharmendra Kumar Yadav, Vigyasa Singh, Feroz Khan, Mahendra Kumar Gupta, Mastan Singh, Mahendra P Darokar, Santosh Kumar Srivastava
The emergence of multidrug resistance (MDR) in Gram negative bacteria (GNB) and lack of novel classes of antibacterial agents have raised an immediate need to identify antibacterial agents, which can reverse the phenomenon of MDR. The purpose of present study was to evaluate synergy potential and understanding the drug resistance reversal mechanism of chanoclavine isolated from Ipomoea muricata against the multidrug resistant clinical isolate of Escherichia coli (MDREC). Although chanoclavine did not show antibacterial activity of its own, but in combination, it could reduce the minimum inhibitory concentration (MIC) of tetracycline (TET) up to 16 folds...
March 29, 2018: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29589993/incidence-of-multidrug-resistant-organism-among-children-admitted-to-pediatric-intensive-care-unit-in-a-developing-country
#14
Ahmed El-Nawawy, Galal A Ashraf, Manal A M Antonios, Marwa A Meheissen, Marwa M R El-Alfy
AIM: Multidrug-resistant infections are an increasingly common condition particularly in critical care units. This study aimed to determine the incidence and types of resistant bacteria acquired in a pediatric intensive care unit (PICU) of a university hospital. SUBJECT AND METHODS: A prospective study was conducted during the year 2016. All children aged below 16 years were studied for infection development and pattern of susceptibility to various groups of antibiotics...
March 28, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29587634/high-throughput-detection-of-rna-processing-in-bacteria
#15
Erin E Gill, Luisa S Chan, Geoffrey L Winsor, Neil Dobson, Raymond Lo, Shannan J Ho Sui, Bhavjinder K Dhillon, Patrick K Taylor, Raunak Shrestha, Cory Spencer, Robert E W Hancock, Peter J Unrau, Fiona S L Brinkman
BACKGROUND: Understanding the RNA processing of an organism's transcriptome is an essential but challenging step in understanding its biology. Here we investigate with unprecedented detail the transcriptome of Pseudomonas aeruginosa PAO1, a medically important and innately multi-drug resistant bacterium. We systematically mapped RNA cleavage and dephosphorylation sites that result in 5'-monophosphate terminated RNA (pRNA) using monophosphate RNA-Seq (pRNA-Seq). Transcriptional start sites (TSS) were also mapped using differential RNA-Seq (dRNA-Seq) and both datasets were compared to conventional RNA-Seq performed in a variety of growth conditions...
March 27, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29567140/augmentation-of-the-antibacterial-activities-of-pt5-derived-antimicrobial-peptides-amps-by-amino-acid-substitutions-design-of-novel-amps-against-mdr-bacteria
#16
Yashuo Wang, Pengfei Cui, Yubo Zhang, Qingyun Yang, Shicui Zhang
The ever-growing concerns on multi-drug resistant (MDR) bacteria lead to urgent demands for novel antibiotics including antimicrobial peptides (AMPs). Pt5, a peptide consisting of the C-terminal 55 residues of zebrafish phosvitin, has been shown to function as an antibacterial agent. Here we used Pt5 as a template to design new AMPs by shortening the sequence and substituting with tryptophan (W) and lysine (K) at selected positions. Among the resultant Pt5-derived peptides, Pt5-1c showed the strongest antimicrobial activity against both Gram-negative and Gram-positive bacteria, including MDR bacteia, with the minimum inhibitory concentrations (MICs) ranging from 1...
March 19, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29566404/in-vitro-effects-of-homeopathic-drugs-on-cultured-escherichia-coli
#17
Jürgen Pannek, Carmen Kurmann, Esther Imbach, Felix Amsler, Susanne Pannek-Rademacher
BACKGROUND:  Recurrent urinary tract infections (UTIs) are one of the most common morbidities in persons with neurogenic lower urinary tract dysfunction (NLUTD). Repetitive antibiotic treatment increases the risk of selecting multi-resistant bacteria. Homeopathic treatment has been reported to be effective in these patients. The mechanism of action, however, has not been clarified. Recently, a direct bactericidal effect of homeopathic remedies was shown. Such an effect is not in accordance with the general principles of homeopathy...
March 22, 2018: Homeopathy: the Journal of the Faculty of Homeopathy
https://www.readbyqxmd.com/read/29564898/aggregation-induced-emission-probe-for-study-of-the-bactericidal-mechanism-of-antimicrobial-peptides
#18
Junjian Chen, Meng Gao, Lin Wang, Shiwu Li, Jingcai He, Anjun Qin, Li Ren, Yingjun Wang, Ben Zhong Tang
Multidrug resistant bacterial infection has become one of the most serious threats to human health. Antimicrobial peptides (AMPs) have been identified as potential alternatives to antibiotics owing to their excellent bactericidal activity. However, the complicated bactericidal mechanism of AMPs is still poorly understood. Fluorescence imaging has many advantages in terms of dynamic monitoring, easy operation, and high sensitivity. In this study, we developed an aggregation-induced emission (AIE)-active probe AMP-2HBT by decorating the antimicrobial peptide HHC36 (KRWWKWWRR) with an AIEgen of 2-(2-hydroxyphenyl)benzothiazole (HBT)...
April 11, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29560313/tigecycline-associated-hypofibrinogenemia-a-case-report-and-review-of-the-literature
#19
Pei-Chun Wu, Chien-Chih Wu
Tigecycline, a glycylcycline-derived antibacterial that has been approved for the treatment of various infections, is widely used for multi-drug resistant bacteria. Coagulopathy is an uncommon side effect during tigecycline treatment and is easily overlooked when it occurs. We reported the effect of tigecycline (50 mg every twelve hours) treatment in an 87-year-old man, with Gram negative bacillary pneumonia and respiratory failure. After 7 days of tigecycline treatment, a significant drop of hemoglobin and patchy ecchymosis over both thighs were suddenly observed despite stable clinical condition...
2018: IDCases
https://www.readbyqxmd.com/read/29556217/molecular-and-conventional-analysis-of-acute-diarrheal-isolates-identifies-epidemiological-trends-antibiotic-resistance-and-virulence-profiles-of-common-enteropathogens-in-shanghai
#20
Feng Yang, Yonggen Jiang, Lihua Yang, Juanxiu Qin, Mingquan Guo, Yuxia Lu, Hongyou Chen, Yuan Zhuang, Jinghao Zhang, Hong Zhang, Zhaoyun Dai, Min Li, Changqing Yang, Min Chen, Yanmei Zhang, Hu Zhao
Objective: To investigate prevalence of acute diarrhea in Shanghai and analyze virulence associated-genes and antibiotic resistance of major enteropathogens using combination of conventional and molecular epidemiology methods. Method: The 412 stool specimens were obtained by systematic sampling from diarrhea patients throughout entire year 2016. Bacterial and viral pathogens were identified and bacterial isolates were cultured and screened for antibiotic resistance profiles. Two most prevalent bacteria, Vibrio parahaemolyticus and Salmonella were further typed by multi-locus sequence typing (MLST) and analyzed for presence of virulence-associated genes...
2018: Frontiers in Microbiology
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