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https://www.readbyqxmd.com/read/28729623/3d-qsar-studies-on-maslinic-acid-analogs-for-anticancer-activity-against-breast-cancer-cell-line-mcf-7
#1
Sarfaraz Alam, Feroz Khan
Global prevalence of breast cancer and its rising frequency makes it a key area of research in drug discovery programs. The research article describes the development of field based 3D-QSAR model based on human breast cancer cell line MCF7 in vitro anticancer activity, which defines the molecular level understanding and regions of structure-activity relationship for triterpene maslinic acid and its analogs. The key features such as average shape, hydrophobic regions and electrostatic patterns of active compounds were mined and mapped to virtually screen potential analogs...
July 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28726744/future-protein-supply-and-demand-strategies-and-factors-influencing-a-sustainable-equilibrium
#2
REVIEW
Maeve Henchion, Maria Hayes, Anne Maria Mullen, Mark Fenelon, Brijesh Tiwari
A growing global population, combined with factors such as changing socio-demographics, will place increased pressure on the world's resources to provide not only more but also different types of food. Increased demand for animal-based protein in particular is expected to have a negative environmental impact, generating greenhouse gas emissions, requiring more water and more land. Addressing this "perfect storm" will necessitate more sustainable production of existing sources of protein as well as alternative sources for direct human consumption...
July 20, 2017: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28725975/supporting-sustainability-initiatives-through-biometeorology-education-and-training
#3
Michael J Allen, Jennifer Vanos, David M Hondula, Daniel J Vecellio, David Knight, Hamed Mehdipoor, Rebekah Lucas, Chris Fuhrmann, Hanna Lokys, Angela Lees, Sheila Tavares Nascimento, Andrew C W Leung, David R Perkins
The International Society of Biometeorology (ISB) has covered significant breadth and depth addressing fundamental and applied societal and environmental challenges in the last 60 years. Biometeorology is an interdisciplinary science connecting living organisms to their environment, but there is very little understanding of the existence and placement of this discipline within formal educational systems and institutions. It is thus difficult to project the ability of members of the biometeorological community-especially the biometeorologists of the future-to help solve global challenges...
July 19, 2017: International Journal of Biometeorology
https://www.readbyqxmd.com/read/28717741/patient-reported-burden-of-a-neuroendocrine-tumor-net-diagnosis-results-from-the-first-global-survey-of-patients-with-nets
#4
Simron Singh, Dan Granberg, Edward Wolin, Richard Warner, Maia Sissons, Teodora Kolarova, Grace Goldstein, Marianne Pavel, Kjell Öberg, John Leyden
PURPOSE: Despite the considerable impact of neuroendocrine tumors (NETs) on patients' daily lives, the journey of the patient with a NET has rarely been documented, with published data to date being limited to small qualitative studies. NETs are heterogeneous malignancies with nonspecific symptomology, leading to extensive health care use and diagnostic delays that affect survival. A large, international patient survey was conducted to increase understanding of the experience of the patient with a NET and identify unmet needs, with the aim of improving disease awareness and care worldwide...
February 2017: Journal of Global Oncology
https://www.readbyqxmd.com/read/28715679/a-parametric-study-on-hydraulic-conductivity-and-self-healing-properties-of-geotextile-clay-liners-used-in-landfills
#5
Fatemeh Parastar, Sayyed Mahdi Hejazi, Mohammad Sheikhzadeh, Azam Alirezazadeh
Nowadays, the raise of excessive generation of solid wastes is considered as a major environmental concern due to the fast global population growth. The contamination of groundwater from landfill leachate compromises every living creature. Geotextile clay liner (GCL) that has a sandwich structure with two fibrous sheets and a clay core can be considered as an engineered solution to prevent hazardous pollutants from entering into groundwater. The main objective of the present study is therefore to enhance the performance of GCL structures...
July 14, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28709947/combination-of-whole-spine-lateral-radiograph-and-lateral-scanogram-in-the-assessment-of-global-sagittal-balance
#6
Chang-Hoon Jeon, Kyu-Sung Kwack, Sunghoon Park, Han-Dong Lee, Nam-Su Chung
BACKGROUND CONTEXT: Global balance of human standing is analyzed as the geometric sum of the individual alignments extending from the spinal column to the pelvis, and to the lower limbs. The innovative EOS system has opened new perspectives for the global analysis of whole body alignment, but its use is very limited due to its high cost. An alternative may be to combine the whole spine lateral radiograph and the lateral scanogram in the global sagittal analysis of whole body alignment...
July 11, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28706989/inactivation-of-thermogenic-ucp1-as-a-historical-contingency-in-multiple-placental-mammal-clades
#7
Michael J Gaudry, Martin Jastroch, Jason R Treberg, Michael Hofreiter, Johanna L A Paijmans, James Starrett, Nathan Wales, Anthony V Signore, Mark S Springer, Kevin L Campbell
Mitochondrial uncoupling protein 1 (UCP1) is essential for nonshivering thermogenesis in brown adipose tissue and is widely accepted to have played a key thermoregulatory role in small-bodied and neonatal placental mammals that enabled the exploitation of cold environments. We map ucp1 sequences from 133 mammals onto a species tree constructed from a ~51-kb sequence alignment and show that inactivating mutations have occurred in at least 8 of the 18 traditional placental orders, thereby challenging the physiological importance of UCP1 across Placentalia...
July 2017: Science Advances
https://www.readbyqxmd.com/read/28702569/the-borazine-dimer-the-case-of-a-dihydrogen-bond-competing-with-a-classical-hydrogen-bond
#8
Kanupriya Verma, K S Viswanathan
Dimers of borazine were studied using matrix isolation infrared spectroscopy and ab initio quantum chemical calculations. Computations were performed at the MP2 and M06-2X levels of theory using the 6-311++G(d,p) and aug-cc-pVDZ basis sets for the various homodimers. At both levels of theory, an aligned stacked structure was found to be the global minimum, which was nearly isoenergetic to a parallel displaced structure. A T-shaped structure, where the N-H of one borazine pointed towards the N of the second borazine, was found to be a local minimum...
July 12, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28701966/quantifying-and-modeling-coordination-and-coherence-in-pedestrian-groups
#9
Adam W Kiefer, Kevin Rio, Stéphane Bonneaud, Ashley Walton, William H Warren
Coherent collective behavior emerges from local interactions between individuals that generate group dynamics. An outstanding question is how to quantify group coordination of non-rhythmic behavior, in order to understand the nature of these dynamics at both a local and global level. We investigate this problem in the context of a small group of four pedestrians walking to a goal, treating their speed, and heading as behavioral variables. To measure the local coordination between pairs of pedestrians, we employ cross-correlation to estimate coupling strength and cross-recurrence quantification (CRQ) analysis to estimate dynamic stability...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28693008/two-landmark-studies-published-in-1976-1977-paved-the-way-for-the-recognition-of-human-papillomavirus-as-the-major-cause-of-the-global-cancer-burden
#10
Kari J Syrjänen
Two groundbreaking reports were published in Acta Cytologica at the transition of 1976 to 1977. One appeared in the last issue of 1976 [Meisels and Fortin: Acta Cytol 1976;20:505-509] and the other in the first issue of 1977 [Purola and Savia: Acta Cytol 1977;21:26-31]. Today, 40 years later, it is not an overstatement to conclude that these are the two most influential studies ever published in this journal. Two reports with a similar content being published so close together (in the same journal) raised the question "Which of the two reports was truly submitted first?" In this commentary, this enigma is clarified beyond reasonable doubt, based on the well-considered testimonial of Prof...
July 11, 2017: Acta Cytologica
https://www.readbyqxmd.com/read/28688624/indirect-decompression-in-spinal-surgery
#11
REVIEW
Hiroyuki Yoshihara
Indirect decompression in spinal surgery means decompression of spinal nerve tissues, such as spinal cord and nerve, without resecting the compressing tissue. Indirect spinal decompression procedures largely can be divided into segmental procedures and global spinal alignment procedures. Segmental procedures are mainly performed by the distraction between two vertebrae, which lead to the opening of the neural foramen and increases the epidural space. Such distraction can be performed through the disc space or using posterior instrumentation...
July 5, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28680690/role-of-growth-rate-on-the-orientational-alignment-of-escherichia-coli-in-a-slit
#12
Julian Sheats, Bianca Sclavi, Marco Cosentino Lagomarsino, Pietro Cicuta, Kevin D Dorfman
We present experimental data on the nematic alignment of Escherichia coli bacteria confined in a slit, with an emphasis on the effect of growth rate and corresponding changes in cell aspect ratio. Global alignment with the channel walls arises from the combination of local nematic ordering of nearby cells, induced by cell division and the elongated shape of the cells, and the preferential orientation of cells proximate to the side walls of the slit. Decreasing the growth rate leads to a decrease in alignment with the walls, which is attributed primarily to effects of changing cell aspect ratio rather than changes in the variance in cell area...
June 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28678704/auto-context-convolutional-neural-network-auto-net-for-brain-extraction-in-magnetic-resonance-imaging
#13
Seyed Sadegh Mohseni Salehi, Deniz Erdogmus, Ali Gholipour
Brain extraction or whole brain segmentation is an important first step in many of the neuroimage analysis pipelines. The accuracy and robustness of brain extraction, therefore, is crucial for the accuracy of the entire brain analysis process. State-of-the-art brain extraction techniques rely heavily on the accuracy of alignment or registration between brain atlases and query brain anatomy, and/or make assumptions about the image geometry; therefore have limited success when these assumptions do not hold or image registration fails...
June 28, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28672040/comparative-transcript-profiling-explores-differentially-expressed-genes-associated-with-sexual-phenotype-in-kiwifruit
#14
Ping Tang, Qiong Zhang, Xiaohong Yao
BACKGROUND: Kiwifruit is a perennial, deciduous and functionally dioecious plant. However, very little is known about the whole-genome molecular mechanisms contributing to distinct sexual phenotypes. To gain a global view of genes differentially expressed between male and female flowers, we analyzed genome-wide gene expression profiles in the flowers of male and female plants using high-throughput RNA sequencing. RESULTS: A total of 53.5 million reads were generated...
2017: PloS One
https://www.readbyqxmd.com/read/28664514/comparative-and-bioinformatics-analyses-of-pathogenic-bacterial-secretomes-identified-by-mass-spectrometry-in-burkholderia-species
#15
Thao Thi Nguyen, Tae-Soo Chon, Jaehan Kim, Young-Su Seo, Muyoung Heo
Secreted proteins (secretomes) play crucial roles during bacterial pathogenesis in both plant and human hosts. The identification and characterization of secretomes in the two plant pathogens Burkholderia glumae BGR1 and B. gladioli BSR3, which cause diseases in rice such as seedling blight, panicle blight, and grain rot, are important steps to not only understand the disease-causing mechanisms but also find remedies for the diseases. Here, we identified two datasets of secretomes in B. glumae BGR1 and B. gladioli BSR3, which consist of 118 and 111 proteins, respectively, using mass spectrometry approach and literature curation...
July 2017: Journal of Microbiology / the Microbiological Society of Korea
https://www.readbyqxmd.com/read/28664198/3d-motion-modeling-and-reconstruction-of-left-ventricle-wall-in-cardiac-mri
#16
Dong Yang, Pengxiang Wu, Chaowei Tan, Kilian M Pohl, Leon Axel, Dimitris Metaxas
The analysis of left ventricle (LV) wall motion is a critical step for understanding cardiac functioning mechanisms and clinical diagnosis of ventricular diseases. We present a novel approach for 3D motion modeling and analysis of LV wall in cardiac magnetic resonance imaging (MRI). First, a fully convolutional network (FCN) is deployed to initialize myocardium contours in 2D MR slices. Then, we propose an image registration algorithm to align MR slices in space and minimize the undesirable motion artifacts from inconsistent respiration...
June 2017: Functional Imaging and Modeling of the Heart: ... International Workshop, FIMH ..., Proceedings. FIMH
https://www.readbyqxmd.com/read/28663738/cerebral-microstructural-alterations-after-radiation-therapy-in-high-grade-glioma-a-diffusion-tensor-imaging-based-study
#17
Rebecca Kassubek, Martin Gorges, Mike-Andrew Westhoff, Albert C Ludolph, Jan Kassubek, Hans-Peter Müller
OBJECTIVE: To investigate radiation therapy-induced microstructural damage of white matter in patients with high-grade glioma by diffusion tensor imaging (DTI). METHODS: DTI was performed in 18 patients with high-grade glioma (WHO grades III and IV) and 13 healthy controls. DTI images were cross-sectionally aligned for the calculation of baseline fractional anisotropy (FA). Interhemispheric FA values in patients with high-grade glioma before or without brain radiation therapy were compared with the interhemispheric FA values in patients after radiation therapy and in healthy controls...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28658032/assessment-of-the-change-in-alignment-of-fixed-segment-after-adult-spinal-deformity-surgery
#18
Tomohiro Banno, Tomohiko Hasegawa, Yu Yamato, Sho Kobayashi, Daisuke Togawa, Go Yoshida, Tatsuya Yasuda, Shin Oe, Yuki Mihara, Hiroki Ushirozako, Yukihiro Matsuyama
STUDY DESIGN: Retrospective study OBJECTIVE.: To determine the prevalence of loss in fixed segment alignment after surgical correction of adult spinal deformity (ASD) and identify associated risk factors. SUMMARY OF BACKGROUND DATA: Altered fixed segment alignment influences global spinal alignment; however, associated risk factors have not been determined. METHODS: Data of 63 patients with ASD (55 women; mean age, 68.0 years), who underwent corrective fusion from the lower thoracic spine to the pelvis and completed the 2-year follow-up, were retrospectively analyzed...
June 27, 2017: Spine
https://www.readbyqxmd.com/read/28655818/novel-plasmid-mediated-colistin-resistance-gene-mcr-3-in-escherichia-coli
#19
Wenjuan Yin, Hui Li, Yingbo Shen, Zhihai Liu, Shaolin Wang, Zhangqi Shen, Rong Zhang, Timothy R Walsh, Jianzhong Shen, Yang Wang
The mobile colistin resistance gene mcr-1 has attracted global attention, as it heralds the breach of polymyxins, one of the last-resort antibiotics for the treatment of severe clinical infections caused by multidrug-resistant Gram-negative bacteria. To date, six slightly different variants of mcr-1, and a second mobile colistin resistance gene, mcr-2, have been reported or annotated in the GenBank database. Here, we characterized a third mobile colistin resistance gene, mcr-3 The gene coexisted with 18 additional resistance determinants in the 261-kb IncHI2-type plasmid pWJ1 from porcine Escherichia colimcr-3 showed 45...
June 27, 2017: MBio
https://www.readbyqxmd.com/read/28650523/characterization-of-the-phosphate-specific-transport-system-in-cronobacter-sakazakii-baa-894
#20
Xiujun Liang, Xiaoqing Hu, Xiaoyuan Wang, Jianli Wang, Yu Fang, Yanyan Li
AIMS: Characterize the phosphate-specific transport system in Cronobacter sakazakii BAA-894. METHODS AND RESULTS: The genes relevant to phosphate transfer in C. sakazakii BAA-894 were determined by using sequence alignment to the corresponding genes in Escherichia coli. Then, the determined pst operon in C. sakazakii BAA-894 was deleted using the lambda Red recombination system. Using the wild type C. sakazakii BAA-894 as a control, the membrane permeability, auto-aggregation, exopolysaccharide biosynthesis, biofilm formation, and adhesion ability of the mutant △pst grown in media containing high or low concentrations of phosphate were investigated; stronger auto-aggregation, less biofilm formation and higher adhesion ability were observed in △pst cells grown in low phosphate media...
June 26, 2017: Journal of Applied Microbiology
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