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https://www.readbyqxmd.com/read/28333980/evaluating-alignment-and-variant-calling-software-for-mutation-identification-in-c-elegans-by-whole-genome-sequencing
#1
Harold E Smith, Sijung Yun
Whole-genome sequencing is a powerful tool for analyzing genetic variation on a global scale. One particularly useful application is the identification of mutations obtained by classical phenotypic screens in model species. Sequence data from the mutant strain is aligned to the reference genome, and then variants are called to generate a list of candidate alleles. A number of software pipelines for mutation identification have been targeted to C. elegans, with particular emphasis on ease of use, incorporation of mapping strain data, subtraction of background variants, and similar criteria...
2017: PloS One
https://www.readbyqxmd.com/read/28333165/mass-coral-mortality-under-local-amplification-of-2%C3%A2-%C3%A2-c-ocean-warming
#2
Thomas M DeCarlo, Anne L Cohen, George T F Wong, Kristen A Davis, Pat Lohmann, Keryea Soong
A 2 °C increase in global temperature above pre-industrial levels is considered a reasonable target for avoiding the most devastating impacts of anthropogenic climate change. In June 2015, sea surface temperature (SST) of the South China Sea (SCS) increased by 2 °C in response to the developing Pacific El Niño. On its own, this moderate, short-lived warming was unlikely to cause widespread damage to coral reefs in the region, and the coral reef "Bleaching Alert" alarm was not raised. However, on Dongsha Atoll, in the northern SCS, unusually weak winds created low-flow conditions that amplified the 2 °C basin-scale anomaly...
March 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28327209/dietary-vitamin-a-intake-recommendations-revisited-global-confusion-requires-alignment-of-the-units-of-conversion-and-expression
#3
Alida Melse-Boonstra, Marieke Vossenaar, Carolien A van Loo-Bouwman, Klaus Kraemer, Saskia de Pee, Keith P West, Robert M Russell, Noel W Solomons
No abstract text is available yet for this article.
March 22, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28327124/exploring-the-influence-of-cultural-orientations-on-assessment-of-communication-behaviours-during-patient-practitioner-interactions
#4
Kyle J Wilby, Marjan J B Govaerts, Zubin Austin, Diana H J M Dolmans
BACKGROUND: Research has shown that patients' and practitioners' cultural orientations affect communication behaviors and interpretations in cross-cultural patient-practitioner interactions. Little is known about the effect of cultural orientations on assessment of communication behaviors in cross-cultural educational settings. The purpose of this study is to explore cultural orientation as a potential source of assessor idiosyncrasy or between-assessor variability in assessment of communication skills...
March 21, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/28326907/skin-sensitizers-in-cosmetics-and-beyond-potential-multiple-mechanisms-of-action-and-importance-of-t-cell-assays-for-in-vitro-screening
#5
Stanislav Vukmanović, Nakissa Sadrieh
Allergic contact dermatitis (ACD) is a delayed-type hypersensitivity (DTH) reaction induced by repeated contact with sensitizers. The ability of a chemical to act as a sensitizer has most frequently been tested in animals. As the use of animals for these purposes is gradually and globally being phased out, there is a need for reliable in vitro surrogate assays. Currently proposed in vitro assays are designed to test four key events of the adverse outcome pathway (AOP) involving covalent modification of self-proteins by sensitizers (haptenation) and presentation of new antigens (hapten/carrier complexes) to the immune system...
March 22, 2017: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/28314493/beyond-visas-and-vaccines-preparing-students-for-domestic-and-global-health-engagement
#6
EDITORIAL
Lisa V Adams, Anne N Sosin
At campuses across the United States, scores of students are embarking on global health experiences in low- and middle-income countries. The desire to improve the health of poor communities while preparing for future health careers is often the main driver. The spotlight on domestic health issues also has fueled a resurgence of interest in underserved communities in the United States. Regardless of the destination, rigorous preparation is needed to ensure that the students' presence benefits the communities they aim to serve...
November 2016: Annals of Global Health
https://www.readbyqxmd.com/read/28306640/cervical-alignment-variations-in-different-postures-and-predictors-of-normal-cervical-kyphosis-a-new-understanding
#7
Hwee Weng Dennis Hey, Eugene Tze-Chun Lau, Chengyuan Gordon Wong, Kimberly-Anne Tan, Gabriel Ka-Po Liu, Hee-Kit Wong
STUDY DESIGN: Prospective comparative study OBJECTIVE.: To predict physiological alignment of the cervical spine and study its morphology in different postures. SUMMARY OF BACKGROUND DATA: There is increasing evidence that normal cervical spinal alignment may vary from lordosis to neutral to kyphosis, or form S-shaped or reverse S-shaped curves. METHODS: Standing, erect sitting and natural sitting whole spine radiographs were obtained from 26 consecutive patients without cervical spine pathology...
March 16, 2017: Spine
https://www.readbyqxmd.com/read/28304232/a-systematic-evaluation-of-intraoperative-white-matter-tract-shift-in-pediatric-epilepsy-surgery-using-high-field-mri-and-probabilistic-high-angular-resolution-diffusion-imaging-tractography
#8
Joseph Yuan-Mou Yang, Richard Beare, Marc L Seal, A Simon Harvey, Vicki A Anderson, Wirginia J Maixner
OBJECTIVE Characterization of intraoperative white matter tract (WMT) shift has the potential to compensate for neuronavigation inaccuracies using preoperative brain imaging. This study aimed to quantify and characterize intraoperative WMT shift from the global hemispheric to the regional tract-based scale and to investigate the impact of intraoperative factors (IOFs). METHODS High angular resolution diffusion imaging (HARDI) diffusion-weighted data were acquired over 5 consecutive perioperative time points (MR1 to MR5) in 16 epilepsy patients (8 male; mean age 9...
March 17, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/28299786/changing-nurse-licensing-examinations-media-analysis-and-implications-of-the-canadian-experience
#9
L McGillis Hall, M Lalonde, J Kashin, C Yoo, J Moran
AIM: This study examines perceptions of the implementation of National Council Licensing Examination in Canada through a content analysis of articles in the media. BACKGROUND: Public opinions of nursing in the media have been acknowledged as important for the profession, specifically in relation to their portrayal of nursing. INTRODUCTION: The Canadian Council of Registered Nurse Regulators began using the US-based National Council Licensing Examination as entry examination (also known widely as NCLEX) for Canada's registered nurses, discontinuing the previous Canadian Registered Nurse Examination in 2015...
March 15, 2017: International Nursing Review
https://www.readbyqxmd.com/read/28297912/long-range-nematic-order-and-anomalous-fluctuations-in-suspensions-of-swimming-filamentous-bacteria
#10
Daiki Nishiguchi, Ken H Nagai, Hugues Chaté, Masaki Sano
We study the collective dynamics of elongated swimmers in a very thin fluid layer by devising long filamentous nontumbling bacteria. The strong confinement induces weak nematic alignment upon collision, which, for large enough density of cells, gives rise to global nematic order. This homogeneous but fluctuating phase, observed on the largest experimentally accessible scale of millimeters, exhibits the properties predicted by standard models for flocking, such as the Vicsek-style model of polar particles with nematic alignment: true long-range nematic order and nontrivial giant number fluctuations...
February 2017: Physical Review. E
https://www.readbyqxmd.com/read/28295413/using-a-handheld-stereo-depth-camera-to-overcome-limited-field-of-view-in-simulation-imaging-for-radiation-therapy-treatment-planning
#11
Cesare Jenkins, Lei Xing, Amy Yu
PURPOSE: A correct body contour is essential for reliable treatment planning in radiation therapy. While modern medical imaging technologies provide highly accurate patient modeling, there are times when a patient's anatomy cannot be fully captured or there is a lack of easy access to computed tomography (CT) simulation. Here we provide a practical solution to the surface contour truncation problem by using a handheld stereo depth camera (HSDC) to obtain the missing surface anatomy and a surface-surface image registration to stich the surface data into the CT dataset for treatment planning...
March 11, 2017: Medical Physics
https://www.readbyqxmd.com/read/28291407/an-assessment-of-the-most-reliable-method-to-estimate-the-sagittal-alignment-of-the-cervical-spine-analysis-of-a-prospective-cohort-of-138-cases
#12
Roland D Donk, Michael G Fehlings, Wim I M Verhagen, Hisse Arnts, Hans Groenewoud, André L M Verbeek, Ronald H M A Bartels
OBJECTIVE Although there is increasing recognition of the importance of cervical spinal sagittal balance, there is a lack of consensus as to the optimal method to accurately assess the cervical sagittal alignment. Cervical alignment is important for surgical decision making. Sagittal balance of the cervical spine is generally assessed using one of two methods; namely, measuring the angle between C-2 and C-7, and drawing a line between C-2 and C-7. Here, the best method to assess sagittal alignment of the cervical spine is investigated...
March 3, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28291186/efficacy-of-patient-specific-instruments-in-total-knee-arthroplasty-a-systematic-review-and-meta-analysis
#13
Emmanuel Thienpont, Pierre-Emmanuel Schwab, Peter Fennema
BACKGROUND: Patient-specific instrumentation (PSI) was introduced with the aim of making the procedure of total knee arthroplasty more accurate and efficient. The purpose of this study was to compare PSI and standard instrumentation in total knee arthroplasty with regard to radiographic and clinical outcomes as well as operative time and blood loss. METHODS: A meta-analysis was conducted in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement...
March 15, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28289998/slim-slit-lamp-image-mosaicing-handling-reflection-artifacts
#14
Kristina Prokopetc, Adrien Bartoli
PURPOSE: The slit lamp is an essential instrument for eye care. It is used in navigated laser treatment with retina mosaicing to assist diagnosis. Specifics of the imaging setup introduce bothersome illumination artifacts. They not only degrade the quality of the mosaic but may also affect the diagnosis. Existing solutions in SLIM manage to deal with strong glares which corrupt the retinal content entirely while leaving aside the correction of semitransparent specular highlights and lens flare...
March 13, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28287330/accounting-for-abortion-accomplishing-transnational-reproductive-governance-through-post-abortion-care-in-senegal
#15
Siri Suh
Reproductive governance operates through calculating demographic statistics that offer selective truths about reproductive practices, bodies, and subjectivities. Post-abortion care, a global reproductive health intervention, represents a transnational reproductive regime that establishes motherhood as women's primary legitimate reproductive status. Drawing on ethnographic fieldwork conducted in Senegal between 2010 and 2011, I illustrate how post-abortion care accomplishes reproductive governance in a context where abortion is prohibited altogether and the US is the primary bilateral donor of population aid...
March 13, 2017: Global Public Health
https://www.readbyqxmd.com/read/28280284/the-fiber-optic-system-for-the-advanced-topographic-laser-altimeter-system-atlas-instrument
#16
Melanie N Ott, Joe Thomes, Eleanya Onuma, Robert Switzer, Richard Chuska, Diana Blair, Erich Frese, Marc Matyseck
The Advanced Topographic Laser Altimeter System (ATLAS) Instrument has been in integration and testing over the past 18 months in preparation for the Ice, Cloud and Land Elevation Satellite - 2 (ICESat-2) Mission, scheduled to launch in 2017. ICESat-2 is the follow on to ICESat which launched in 2003 and operated until 2009. ATLAS will measure the elevation of ice sheets, glaciers and sea ice or the "cryosphere" (as well as terrain) to provide data for assessing the earth's global climate changes. Where ICESat's instrument, the Geo-Science Laser Altimeter (GLAS) used a single beam measured with a 70 m spot on the ground and a distance between spots of 170 m, ATLAS will measure a spot size of 10 m with a spacing of 70 cm using six beams to measure terrain height changes as small as 4 mm...
August 28, 2016: Proceedings of SPIE
https://www.readbyqxmd.com/read/28276484/acetylation-and-phosphorylation-control-both-local-and-global-stability-of-the-chloroplast-f1-atp-synthase
#17
Carla Schmidt, Victoria Beilsten-Edmands, Shabaz Mohammed, Carol V Robinson
ATP synthases (ATPases) are enzymes that produce ATP and control the pH in the cell or cellular compartments. While highly conserved over different species, ATPases are structurally well-characterised but the existence and functional significance of many post-translational modifications (PTMs) is not well understood. We combined a range of mass spectrometric techniques to unravel the location and extent of PTMs in the chloroplast ATP synthase (cATPase) purified from spinach leaves. We identified multiple phosphorylation and acetylation sites and found that both modifications stabilise binding of ε and δ subunits...
March 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28274217/disruption-of-rcsb-by-a-duplicated-sequence-in-a-curli-producing-escherichia-coli-o157-h7-results-in-differential-gene-expression-in-relation-to-biofilm-formation-stress-responses-and-metabolism
#18
V K Sharma, D O Bayles, D P Alt, T Looft, B W Brunelle, J A Stasko
BACKGROUND: Escherichia coli O157:H7 (O157) strain 86-24, linked to a 1986 disease outbreak, displays curli- and biofilm-negative phenotypes that are correlated with the lack of Congo red (CR) binding and formation of white colonies (CR(-)) on a CR-containing medium. However, on a CR medium this strain produces red isolates (CR(+)) capable of producing curli fimbriae and biofilms. RESULTS: To identify genes controlling differential expression of curli fimbriae and biofilm formation, the RNA-Seq profile of a CR(+) isolate was compared to the CR(-) parental isolate...
March 8, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28268058/investigating-the-spatial-accuracy-of-cbct-guided-cranial-radiosurgery-a-phantom-end-to-end-test-study
#19
Juan-Francisco Calvo-Ortega, Marcelino Hermida-López, Sandra Moragues-Femenía, Miquel Pozo-Massó, Joan Casals-Farran
PURPOSE: To evaluate the spatial accuracy of a frameless cone-beam computed tomography (CBCT)-guided cranial radiosurgery (SRS) using an end-to-end (E2E) phantom test methodology. METHODS AND MATERIALS: Five clinical SRS plans were mapped to an acrylic phantom containing a radiochromic film. The resulting phantom-based plans (E2E plans) were delivered four times. The phantom was setup on the treatment table with intentional misalignments, and CBCT-imaging was used to align it prior to E2E plan delivery...
March 3, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28248611/age-related-variations-in-global-spinal-alignment-and-sagittal-balance-in-asymptomatic-japanese-adults
#20
Kunio Yokoyama, Masahiro Kawanishi, Makoto Yamada, Hidekazu Tanaka, Yutaka Ito, Shinji Kawabata, Toshihiko Kuroiwa
OBJECTIVES: The global spinal sagittal alignment varies widely among healthy individuals as it is affected by not only race, but also aging. We investigated age-related changes in the spinal alignment in asymptomatic Japanese individuals. METHODS: The subjects comprised 220 individuals without any spine-related neurological symptoms or treatment history thereof who visited our outpatient clinic. Lateral radiographs of the whole spine were taken for all subjects in the standing position...
March 1, 2017: Neurological Research
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