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https://www.readbyqxmd.com/read/28527756/radiological-lumbar-stenosis-severity-predicts-worsening-sagittal-malalignment-on-full-body-standing-stereoradiographs
#1
Aaron J Buckland, Subaraman Ramchandran, Louis Day, Shay Bess, Themistocles Protopsaltis, Peter G Passias, Bassel G Diebo, Renaud Lafage, Virginie Lafage, Akhila Sure, Thomas J Errico
BACKGROUND CONTEXT: Patients with degenerative lumbar stenosis (DLS) adopt a forward flexed posture in an attempt to decompress neural elements. The relationship between sagittal alignment and severity of lumbar stenosis has not previously been studied. PURPOSE: We hypothesized that patients with increasing radiological severity of lumbar stenosis will exhibit worsening sagittal alignment. STUDY DESIGN: This is a cross-sectional study. PATIENT SAMPLE: Our sample consists of patients who have DLS...
May 17, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28522402/prophylactic-vertebral-cement-augmentation-at-the-uppermost-instrumented-vertebra-and-rostral-adjacent-vertebra-for-the-prevention-of-proximal-junctional-kyphosis-and-failure-following-long-segment-fusion-for-adult-spinal-deformity
#2
George M Ghobrial, Daniel G Eichberg, John Paul G Kolcun, Karthik Madhavan, Nathan H Lebwohl, Barth A Green, Joseph P Gjolaj
BACKGROUND CONTEXT: Proximal junctional kyphosis (PJK) and proximal junctional failure (PJF) are common problems after long segment (>5 levels) thoracolumbar instrumented fusions in the treatment of adult spinal deformity (ASD). No specific surgical strategy has definitively been shown to lower the risk of PJK as the result of a multifactorial etiology. PURPOSE: To assess the incidence of PJK and PJF in patients treated with prophylactic polymethylmethacrylate(PMMA) cement augmentation at the uppermost instrumented vertebrae(UIV) and rostral adjacent vertebrae(UIV+1)...
May 15, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28520848/pattern-fusion-analysis-by-adaptive-alignment-of-multiple-heterogeneous-omics-data
#3
Qianqian Shi, Chuanchao Zhang, Minrui Peng, Xiangtian Yu, Tao Zeng, Juan Liu, Luonan Chen
Motivation: Integrating different omics profiles is a challenging task, which provides a comprehensive way to understand complex diseases in a multi-view manner. One key for such an integration is to extract intrinsic patterns in concordance with data structures, so as to discover consistent information across various data types even with noise pollution. Thus, we proposed a novel framework called "pattern fusion analysis" (PFA), which performs automated information alignment and bias correction, to fuse local sample-patterns (e...
May 18, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28513674/molecular-organization-in-the-twist-bend-nematic-phase-by-resonant-x-ray-scattering-at-the-se-k-edge-and-by-saxs-waxs-and-gixrd
#4
W D Stevenson, Z Ahmed, X B Zeng, C Welch, G Ungar, G H Mehl
Using a magnetically aligned liquid crystal mixture containing a novel Se-labelled dimer and the difluoroterphenyl dimer DTC5C7, the twist-bend nematic phase (Ntb) was studied by the resonant scattering of hard X-rays and by conventional small and wide-angle X-ray scattering (SAXS, WAXS). Resonant diffraction spots indicated a helix with a 9-12 nm pitch in the Ntb phase and an unprecedentedly high helix orientation. This enabled deconvolution of global and local order parameters. These findings, combined with the simultaneously recorded resonant and non-resonant SAXS and WAXS data, allowed us to construct a locally layered molecular model of the Ntb phase, where the average twisted conformation of each molecule was idealised as a helical segment, matching the local heliconical director field...
May 17, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28507322/rapid-susceptibility-profiling-of-carbapenem-resistant-klebsiella-pneumoniae
#5
K T Mulroney, J M Hall, X Huang, E Turnbull, N M Bzdyl, A Chakera, U Naseer, E M Corea, M J Ellington, K L Hopkins, A L Wester, O Ekelund, N Woodford, T J J Inglis
The expanding global distribution of multi-resistant Klebsiella pneumoniae demands faster antimicrobial susceptibility testing (AST) to guide antibiotic treatment. Current ASTs rely on time-consuming differentiation of resistance and susceptibility after initial isolation of bacteria from a clinical specimen. Here we describe a flow cytometry workflow to determine carbapenem susceptibility from bacterial cell characteristics in an international K. pneumoniae isolate collection (n = 48), with a range of carbapenemases...
May 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28506641/guiding-multimodal-registration-with-learned-optimization-updates
#6
Benjamin Gutierrez-Becker, Diana Mateus, Loic Peter, Nassir Navab
In this paper, we address the multimodal registration problem from a novel perspective, aiming to predict the transformation aligning images directly from their visual appearance. We formulate the prediction as a supervised regression task, with joint image descriptors as input and the output are the parameters of the transformation that guide the moving image towards alignment. We model the joint local appearance with context aware descriptors that capture both local and global cues simultaneously in the two modalities, while the regression function is based on the gradient boosted trees method capable of handling the very large contextual feature space...
May 6, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/28505376/evolutionary-re-wiring-of-p63-and-the-epigenomic-regulatory-landscape-in-keratinocytes-and-its-potential-implications-on-species-specific-gene-expression-and-phenotypes
#7
Isha Sethi, Christian Gluck, Huiqing Zhou, Michael J Buck, Satrajit Sinha
Although epidermal keratinocyte development and differentiation proceeds in similar fashion between humans and mice, evolutionary pressures have also wrought significant species-specific physiological differences. These differences between species could arise in part, by the rewiring of regulatory network due to changes in the global targets of lineage-specific transcriptional master regulators such as p63. Here we have performed a systematic and comparative analysis of the p63 target gene network within the integrated framework of the transcriptomic and epigenomic landscape of mouse and human keratinocytes...
May 13, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28502890/a-quantitative-approach-to-understanding-vertebrate-limb-morphogenesis-at-the-macroscopic-tissue-level
#8
REVIEW
Takayuki Suzuki, Yoshihiro Morishita
To understand organ morphogenetic mechanisms, it is essential to clarify how spatiotemporally-regulated molecular/cellular dynamics causes physical tissue deformation. In the case of vertebrate limb development, while some of the genes and oriented cell behaviors underlying morphogenesis have been revealed, tissue deformation dynamics remains incompletely understood. We here introduce our recent work on the reconstruction of tissue deformation dynamics in chick limb development from cell lineage tracing data...
May 11, 2017: Current Opinion in Genetics & Development
https://www.readbyqxmd.com/read/28502881/multilevel-schwab-grade-ii-osteotomies-for-sagittal-plane-correction-in-the-management-of-adult-spinal-deformity
#9
George M Ghobrial, Nathan H Lebwohl, Barth A Green, Joseph P Gjolaj
BACKGROUND CONTEXT: Prior reports have compared posterior column osteotomies to pedicle subtraction osteotomies in terms of utility for correcting fixed sagittal imbalance in adolescent patients with deformity. No prior reports have described the use of multilevel Smith-Petersen Osteotomies (SPOs) alone for surgical correction in the adult spinal deformity (ASD) population. PURPOSE: To determine the utility of multilevel Smith-Petersen Osteotomies (SPOs) in the management of global sagittal imbalance in adult spinal deformity (ASD) patients...
May 11, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28501956/an-in-vitro-evaluation-of-sagittal-alignment-in-the-cervical-spine-after-insertion-of-supraphysiologic-lordotic-implants
#10
Donald J Blaskiewicz, Jeffrey E Harris, Patrick P Han, Alexander W Turner, Gregory M Mundis
PURPOSE: Cervical spine malalignment can develop as a consequence of degenerative disc disease or following spinal surgery. When normal sagittal alignment of the spine is disrupted, further degeneration may occur adjacent to the deformity. The purpose of this study was to investigate changes in lordosis and sagittal alignment in the cervical spine after insertion of supraphysiologic lordotic implants. METHODS: Eight cadaveric cervical spines (Occiput-T1) were tested...
May 13, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28499848/understanding-obesity-in-the-context-of-an-indigenous-population-a-qualitative-study
#11
Ricky Bell, Catherine Smith, Leigh Hale, Geoffrey Kira, Steve Tumilty
BACKGROUND: Obesity is a progressive global phenomenon that is disparately prevalent amongst Indigenous populations. While there is a growing body of literature investigating the extrinsic contributors to obesity, there is a lack of evidence to elucidate intrinsic drivers in the context of an Indigenous population. METHODS: Qualitative research theory, inclusive of Indigenous knowledge systems, was applied to the narratives of 15 Indigenous (Māori) people aged between 18 and 65 to contextualise their understandings of obesity...
May 9, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28498339/easy-and-fast-reconstruction-of-a-3d-avatar-with-an-rgb-d-sensor
#12
Aihua Mao, Hong Zhang, Yuxin Liu, Yinglong Zheng, Guiqing Li, Guoqiang Han
This paper proposes a new easy and fast 3D avatar reconstruction method using an RGB-D sensor. Users can easily implement human body scanning and modeling just with a personal computer and a single RGB-D sensor such as a Microsoft Kinect within a small workspace in their home or office. To make the reconstruction of 3D avatars easy and fast, a new data capture strategy is proposed for efficient human body scanning, which captures only 18 frames from six views with a close scanning distance to fully cover the body; meanwhile, efficient alignment algorithms are presented to locally align the data frames in the single view and then globally align them in multi-views based on pairwise correspondence...
May 12, 2017: Sensors
https://www.readbyqxmd.com/read/28489619/pediatric-resident-academic-projects-while-on-global-health-electives-ten-years-of-experience-at-the-university-of-minnesota
#13
Michael B Pitt, Tina M Slusher, Cynthia R Howard, Valerie B Cole, Sophia P Gladding
PURPOSE: Many residency programs require residents to complete an academic project as part of a global health (GH) elective. However, there has been little description of the range of projects residents have pursued during GH electives or the extent to which these projects are consistent with proposed best practices. METHOD: The authors conducted a document review of 67 written summaries or copies of presentations of academic projects (hereafter, summaries) completed by pediatric and medicine-pediatric residents at the University of Minnesota while on GH electives from 2005 to 2015...
May 9, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28487147/optimal-affinity-enhancement-by-a-conserved-flexible-linker-controls-p53-mimicry-in-mdmx
#14
Wade Borcherds, Andreas Becker, Lihong Chen, Jiandong Chen, Lucía B Chemes, Gary W Daughdrill
MdmX contains an intramolecular binding motif that mimics the binding of the p53 tumor suppressor. This intramolecular binding motif is connected to the p53 binding domain of MdmX by a conserved flexible linker that is 85 residues long. The sequence of this flexible linker has an identity of 51% based on multiple protein sequence alignments of 52 MdmX homologs. We used polymer statistics to estimate a global KD value for p53 binding to MdmX in the presence of the flexible linker and the intramolecular binding motif by assuming the flexible linker behaves as a wormlike chain...
May 6, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28485887/metabolomics-approach-based-on-uhplc-q-tof-ms-to-identify-the-chemical-constituents-of-the-traditional-chinese-er-zhi-pill
#15
Xunlong Zhong, Yanmei Zhong, Kangqi Yan, Xuerong Xiao, Lian Duan, Ruolun Wang, Laiyou Wang
Er-Zhi-Pill, which consists of Ligustri lucidi fructus and Ecliptae prostratae herba, is a classical traditional Chinese medicinal formulation widely used as a liver-nourishing and kidney-enriching tonic. To identify the bioactive ingredients of Er-Zhi-Pill and characterize the variation of chemical constituents between codecoction and mix of individually decocted L. lucidi fructus and E. prostratae herba, a novel metabolomics approach based on ultra high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry in both positive and negative ion modes, was established to comprehensively analyze chemical constituents and probe distinguishable chemical markers...
May 9, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28479177/immunization-in-pregnancy-clinical-research-in-low-and-middle-income-countries-study-design-regulatory-and-safety-considerations
#16
Sonali Kochhar, Jan Bonhoeffer, Christine E Jones, Flor M Muñoz, Angel Honrado, Jorgen Bauwens, Ajoke Sobanjo-Ter Meulen, Steven Hirschfeld
Immunization of pregnant women is a promising public health strategy to reduce morbidity and mortality among both the mothers and their infants. Establishing safety and efficacy of vaccines generally uses a hybrid design between a conventional interventional study and an observational study that requires enrolling thousands of study participants to detect an unknown number of uncommon events. Historically, enrollment of pregnant women in clinical research studies encountered many barriers based on risk aversion, lack of knowledge, and regulatory ambiguity...
May 4, 2017: Vaccine
https://www.readbyqxmd.com/read/28475056/fast-descriptors-and-correspondence-propagation-for-robust-global-point-cloud-registration
#17
Huan Lei, Guang Jiang, Long Quan
In this paper, we present a robust global approach for point cloud registration from uniformly sampled points. Based on eigenvalues and normals computed from multiple scales, we design fast descriptors to extract local structures of these points. The eigenvalue-based descriptor is effective at finding seed matches with low precision using nearest neighbour search. Generally, recovering the transformation from matches with low precision is rather challenging. Therefore, we introduce a mechanism named correspondence propagation to aggregate each seed match into a set of numerous matches...
May 3, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28474798/evaluation-of-therapeutics-for-advanced-stage-heart-failure-and-other-severely-debilitating-or-life-threatening-diseases
#18
J S Prescott, P A Andrews, R W Baker, M S Bogdanffy, F O Fields, D A Keller, D M Lapadula, N M Mahoney, D E Paul, S J Platz, D Reese, S A Stoch, J J DeGeorge
Severely debilitating or life-threatening (SDLT) diseases include conditions in which life expectancy is short or quality of life is greatly diminished despite available therapies. As such, the medical context for SDLT diseases is comparable to advanced cancer and the benefit versus risk assessment and development of SDLT disease therapeutics should be similar to that of advanced cancer therapeutics. A streamlined development approach would allow patients with SDLT conditions earlier access to therapeutics and increase the speed of progression through development...
May 5, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28473847/the-radial-organization-of-neuronal-primary-cilia-is-acutely-disrupted-by-seizure-and-ischemic-brain-injury
#19
Gregory W Kirschen, Hanxiao Liu, Tracy Lang, Xuelin Liang, Shaoyu Ge, Qiaojie Xiong
BACKGROUND: Neuronal primary cilia are sensory organelles that are critically involved in the proper growth, development, and function of the central nervous system (CNS). Recent work also suggests that they signal in the context of CNS injury, and that abnormal ciliary signaling may be implicated in neurological diseases. METHODS: We quantified the distribution of neuronal primary cilia alignment throughout the normal adult mouse brain by immunohistochemical staining for the primary cilia marker adenylyl cyclase III (ACIII) and measuring the angles of primary cilia with respect to global and local coordinate planes...
April 2017: Frontiers in Biology
https://www.readbyqxmd.com/read/28470856/defining-health-research-for-development-the-perspective-of-stakeholders-from-an-international-health-research-partnership-in-ghana-and-tanzania
#20
Claire Leonie Ward, David Shaw, Evelyn Anane-Sarpong, Osman Sankoh, Marcel Tanner, Bernice Elger
OBJECTIVES: The study uses a qualitative empirical method to define Health Research for Development. This project explores the perspectives of stakeholders in an international health research partnership operating in Ghana and Tanzania. METHODS: We conducted 52 key informant interviews with major stakeholders in an international multicenter partnership between GlaxoSmithKline (GSK, Vaccine Developer) and the global health nonprofit organisation PATH and its Malaria Vaccine Initiative program (PATH/MVI, Funder-Development Partner), (RTS, S) (NCT00866619)...
May 3, 2017: Developing World Bioethics
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