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https://www.readbyqxmd.com/read/28431578/is-the-effectiveness-of-patellofemoral-bracing-modified-by-patellofemoral-alignment-and-trochlear-morphology
#1
Xi Zhang, Jillian P Eyles, Joanna Makovey, Matthew J Williams, David J Hunter
BACKGROUND: This study was performed to determine if the effectiveness of patellofemoral bracing as a treatment for patellofemoral osteoarthritis is influenced by patellofemoral joint alignment and trochlear morphology. We hypothesized that those with more extreme patellar malalignment would benefit more from bracing. METHODS: Thirty-eight patients who had received bracing as part of a comprehensive treatment plan for patellofemoral osteoarthritis were selected for this study...
April 21, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28429061/natural-resource-management-schemes-as-entry-points-for-integrated-landscape-approaches-evidence-from-ghana-and-burkina-faso
#2
Samson Foli, Mirjam A F Ros-Tonen, James Reed, Terry Sunderland
In recognition of the failures of sectoral approaches to overcome global challenges of biodiversity loss, climate change, food insecurity and poverty, scientific discourse on biodiversity conservation and sustainable development is shifting towards integrated landscape governance arrangements. Current landscape initiatives however very much depend on external actors and funding, raising the question of whether, and how, and under what conditions, locally embedded resource management schemes can serve as entry points for the implementation of integrated landscape approaches...
April 20, 2017: Environmental Management
https://www.readbyqxmd.com/read/28428870/gene-expression-profiling-during-the-embryo-to-larva-transition-in-the-giant-red-sea-urchin-mesocentrotus-franciscanus
#3
Juan Diego Gaitán-Espitia, Gretchen E Hofmann
In echinoderms, major morphological transitions during early development are attributed to different genetic interactions and changes in global expression patterns that shape the regulatory program for the specification of embryonic territories. In order more thoroughly to understand these biological and molecular processes, we examined the transcriptome structure and expression profiles during the embryo-to-larva transition of a keystone species, the giant red sea urchin Mesocentrotus franciscanus. Using a de novo assembly approach, we obtained 176,885 transcripts from which 60,439 (34%) had significant alignments to known proteins...
April 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28424527/unified-alignment-of-protein-protein-interaction-networks
#4
Noël Malod-Dognin, Kristina Ban, Nataša Pržulj
Paralleling the increasing availability of protein-protein interaction (PPI) network data, several network alignment methods have been proposed. Network alignments have been used to uncover functionally conserved network parts and to transfer annotations. However, due to the computational intractability of the network alignment problem, aligners are heuristics providing divergent solutions and no consensus exists on a gold standard, or which scoring scheme should be used to evaluate them. We comprehensively evaluate the alignment scoring schemes and global network aligners on large scale PPI data and observe that three methods, HUBALIGN, L-GRAAL and NATALIE, regularly produce the most topologically and biologically coherent alignments...
April 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28419559/impact-of-the-global-burden-of-periodontal-diseases-on-health-nutrition-and-wellbeing-of-mankind-a-call-for-global-action
#5
Maurizio S Tonetti, Søren Jepsen, Lijian Jin, Joan Otomo-Corgel
BACKGROUND: The global burden of periodontal diseases remains high. Population growth trends, changes in risk factors and improved tooth retention will increase the socio-economic burden of periodontitis that is responsible for 3,5 million years lived with disability, 54 billion USD/year in lost productivity and a major portion of the 442 billion USD/year cost for oral diseases. METHODS: In the context of the Milan World Exhibition 2015 "Feeding the Planet, Energy for Life", a green paper was developed and offered for global consultation by the European Federation of Periodontology...
April 17, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28419550/urban-primate-ranging-patterns-gps-collar-deployments-for-macaca-fascicularis-and-m-sylvanus
#6
Amy R Klegarth, Hope Hollocher, Lisa Jones-Engel, Eric Shaw, Benjamin P Y-H Lee, Tessa Feeney, Damian Holmes, Dale Laguea, Agustín Fuentes
The global increase in urbanization is leading to heavier interface between humans and wildlife. Within these anthropogenic landscapes, little is known about ranging patterns, particularly with regard to urban primates. Here we present the results of the first long-term deployment of multiple GPS collars on two species of macaques to investigate the impacts of urbanization on urban primate ranging patterns in Singapore and Gibraltar. Collars data acquisition were excellent with respect to the amount, quality, and accuracy of data collected; however, remote connectivity and drop-off functionality was poor across all deployments...
May 2017: American Journal of Primatology
https://www.readbyqxmd.com/read/28419292/design-and-testing-of-2-novel-scores-that-predict-global-sagittal-alignment-utilizing-cervical-or-lumbar-plain-radiographs
#7
Ezequiel Goldschmidt, Federico Angriman, Bruno Ferreyro, Nitin Agarwal, James Zhou, Katherine Chen, Zachary J Tempel, Peter C Gerszten, Adam S Kanter, David O Okonkwo, Peter Passias, Justin Scheer, Themistocles Protopsaltis, Virginie Lafage, Renaud Lafage, Frank Schwab, Shay Bess, Chris Ames, Justin S Smith, Douglas Burton, D Kojo Hamilton
BACKGROUND: Global sagittal deformity is an established cause of disability. However, measurements of sagittal alignment are often ignored when patients present with symptoms localizing to the cervical or lumbar spine. OBJECTIVE: To develop scoring scales to predict the risk of sagittal malalignment in patients with only cervical or lumbar spine radiographs. METHODS: A retrospective review of a prospectively maintained multicenter adult spinal deformity database was performed...
April 17, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28411458/transformation-diffusion-reconstruction-of-three-dimensional-histology-volumes-from-two-dimensional-image-stacks
#8
Ramón Casero, Urszula Siedlecka, Elizabeth S Jones, Lena Gruscheski, Matthew Gibb, Jürgen E Schneider, Peter Kohl, Vicente Grau
Traditional histology is the gold standard for tissue studies, but it is intrinsically reliant on two-dimensional (2D) images. Study of volumetric tissue samples such as whole hearts produces a stack of misaligned and distorted 2D images that need to be reconstructed to recover a congruent volume with the original sample's shape. In this paper, we develop a mathematical framework called Transformation Diffusion (TD) for stack alignment refinement as a solution to the heat diffusion equation. This general framework does not require contour segmentation, is independent of the registration method used, and is trivially parallelizable...
March 23, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/28411116/global-field-synchronization-in-gamma-range-of-the-sleep-eeg-tracks-sleep-depth-artifact-introduced-by-a-rectangular-analysis-window
#9
Thomas Rusterholz, Peter Achermann, Roland Dürr, Thomas Koenig, Leila Tarokh
BACKGROUND: Investigating functional connectivity between brain networks has become an area of interest in neuroscience. Several methods for investigating connectivity have recently been developed, however, these techniques need to be applied with care. We demonstrate that global field synchronization (GFS), a global measure of phase alignment in the EEG as a function of frequency, must be applied considering signal processing principles in order to yield valid results. NEW METHOD: Multichannel EEG (27 derivations) was analyzed for GFS based on the complex spectrum derived by the fast Fourier transform (FFT)...
April 11, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28408879/comparison-of-in-vivo-and-ex-vivo-mri-for-the-detection-of-structural-abnormalities-in-a-mouse-model-of-tauopathy
#10
Holly E Holmes, Nick M Powell, Da Ma, Ozama Ismail, Ian F Harrison, Jack A Wells, Niall Colgan, James M O'Callaghan, Ross A Johnson, Tracey K Murray, Zeshan Ahmed, Morten Heggenes, Alice Fisher, M Jorge Cardoso, Marc Modat, Michael J O'Neill, Emily C Collins, Elizabeth M C Fisher, Sébastien Ourselin, Mark F Lythgoe
With increasingly large numbers of mouse models of human disease dedicated to MRI studies, compromises between in vivo and ex vivo MRI must be fully understood in order to inform the choice of imaging methodology. We investigate the application of high resolution in vivo and ex vivo MRI, in combination with tensor-based morphometry (TBM), to uncover morphological differences in the rTg4510 mouse model of tauopathy. The rTg4510 mouse also offers a novel paradigm by which the overexpression of mutant tau can be regulated by the administration of doxycycline, providing us with a platform on which to investigate more subtle alterations in morphology with morphometry...
2017: Frontiers in Neuroinformatics
https://www.readbyqxmd.com/read/28407747/antipsychotic-prescribing-for-vulnerable-populations-a-clinical-audit-at-an-acute-australian-mental-health-unit-at-two-time-points
#11
Sara S McMillan, Sara Jacobs, Louise Wilson, Theo Theodoros, Gail Robinson, Claire Anderson, Gabor Mihala, Amanda J Wheeler
BACKGROUND: Antipsychotics are recognised as a critical intervention for schizophrenia and bipolar disorder. Guidelines globally endorse the routine practice of antipsychotic monotherapy, at the minimum effective dose. Even in treatment-resistant schizophrenia, clozapine use is endorsed before combining antipsychotics. This aim of this study was to review antipsychotic polytherapy alone, high-dose therapy alone, polytherapy and high-dose prescribing patterns in adults discharged from an inpatient mental health unit at two time-points, and the alignment of this prescribing with clinical guideline recommendations...
April 13, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28402485/evolution-of-sagittal-imbalance-following-corrective-surgery-for-sagittal-plane-deformity
#12
Michael M McDowell, Zachary J Tempel, Gurpreet S Gandhoke, Nicholas K Khattar, D Kojo Hamilton, Adam S Kanter, David O Okonkwo
BACKGROUND: Sagittal balance in adult spinal deformity is a major predictor of quality of life. A temporary loss of paraspinal muscle force and somatic pain following spine surgery may limit a patient's ability to maintain posture. OBJECTIVE: To assess the evolution of sagittal balance and clinical outcomes during recovery from adult spinal deformity surgery. METHODS: Retrospective review of a prospective observational database identified a consecutive series of patients with sagittal vertical axis (SVA) > 40 mm undergoing adult deformity surgery...
April 10, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28398992/translating-technical-support-into-country-action-the-role-of-the-interagency-task-team-on-the-prevention-and-treatment-of-hiv-infection-in-pregnant-women-mothers-and-children-in-the-global-plan-era
#13
Chewe Luo, Gottfried Hirnschall, Jessica Rodrigues, Sostena Romano, Shaffiq Essajee, Braeden Rogers, Elizabeth McCarthy, Albert Mwango, Nalinee Sangrujee, Michelle R Adler, James C Houston, Judite O Langa, Marilena Urso, Omotayo Bolu, Gilbert Tene, Jean B Elat Nfetam, Etienne Kembou, Benjamin R Phelps
While the Interagency Task Team on the Prevention and Treatment of HIV Infection in Pregnant Women, Mothers, and Children (IATT) partnership existed before the Global Plan Towards the Elimination of New HIV Infections Among Children by 2015 and Keeping Their Mothers Alive (Global Plan), its reconfiguration was critical to coordinating provision of technical assistance that positively influenced country decision-making and program performance. This article describes how the Global Plan anchored the work of the IATT and, in turn, how the IATT's technical assistance helped to accelerate achievement of the Global Plan targets and milestones...
May 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28395315/creating-a-future-for-occupational-health
#14
Trevor K Peckham, Marissa G Baker, Janice E Camp, Joel D Kaufman, Noah S Seixas
Objectives: Economic, social, technical, and political drivers are fundamentally changing the nature of work and work environments, with profound implications for the field of occupational health. Nevertheless, researchers and practitioners entering the field are largely being trained to assess and control exposures using approaches developed under old models of work and risks. Methods: A speaker series and symposium were organized to broadly explore current challenges and future directions for the occupational health field...
January 1, 2017: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/28392723/the-role-of-eqa-in-harmonization-in-laboratory-medicine-a-global-effort
#15
REVIEW
Graham R D Jones
There are many activities currently being undertaken in the field of laboratory medicine under the broad heading of "harmonization". These include traceability of results to international reference standards, processes to align results from assays where traceability has not been achieved (analytical harmonization) and international or national clinical guidelines based on studies from many parts of the world. Many of these issues are global in nature, with clinical evidence derived from studies performed in all parts of the world and multinational diagnostic companies providing assays worldwide...
February 15, 2017: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://www.readbyqxmd.com/read/28391517/preoperative-digital-planning-versus-postoperative-outcomes-in-total-hip-arthroplasty-using-a-calcar-guided-short-stem-frequent-valgization-can-be-avoided
#16
Karl Philipp Kutzner, Joachim Pfeil, Mark Predrag Kovacevic
INTRODUCTION: Modern total hip arthroplasty is largely dependent on the successful preservation of hip geometry. Thus, a successful implementation of the preoperative planning is of great importance. The present study evaluates the accuracy of anatomic hip reconstruction predicted by 2D digital planning using a calcar-guided short stem of the newest generation. METHODS: A calcar-guided short stem was implanted in 109 patients in combination with a cementless cup using the modified anterolateral approach...
April 8, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28389321/cardiovascular-gene-therapy-past-present-and-future
#17
REVIEW
Seppo Ylä-Herttuala, Andrew H Baker
Cardiovascular diseases remain a large global health problem. Although several conventional small-molecule treatments are available for common cardiovascular problems, gene therapy is a potential treatment option for acquired and inherited cardiovascular diseases that remain with unmet clinical needs. Among potential targets for gene therapy are severe cardiac and peripheral ischemia, heart failure, vein graft failure, and some forms of dyslipidemias. The first approved gene therapy in the Western world was indicated for lipoprotein lipase deficiency, which causes high plasma triglyceride levels...
April 4, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28386613/magnetically-enabled-biomarker-extraction-and-delivery-system-towards-integrated-assured-diagnostic-tools
#18
Westley S Bauer, Danielle W Kimmel, Nicholas M Adams, Lauren E Gibson, Thomas F Scherr, Kelly A Richardson, Joseph A Conrad, Hellen K Matakala, Frederick R Haselton, David W Wright
Diagnosis of asymptomatic malaria poses a great challenge to global disease elimination efforts. Healthcare infrastructure in rural settings cannot support existing state-of-the-art tools necessary to diagnose asymptomatic malaria infections. Instead, lateral flow immunoassays (LFAs) are widely used as a diagnostic tool in malaria endemic areas. While LFAs are simple and easy to use, they are unable to detect low levels of parasite infection. We have developed a field deployable Magnetically-enabled Biomarker Extraction And Delivery System (mBEADS) that significantly improves limits of detection for several commercially available LFAs...
April 7, 2017: Analyst
https://www.readbyqxmd.com/read/28386102/meteorological-fluctuations-define-long-term-crop-yield-patterns-in-conventional-and-organic-production-systems
#19
John R Teasdale, Michel A Cavigelli
Variability in meteorological patterns presents significant challenges to crop production consistency and yield stability. Meteorological influences on corn and soybean grain yields were analyzed over an 18-year period at a long-term experiment in Beltsville, Maryland, U.S.A., comparing conventional and organic management systems. Precipitation and temperature variables explained much of the yield variability, with precipitation and heat stress during the late vegetative and early reproductive phases of crop growth accounting for the majority of yield variability in all crops and management systems...
April 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28385682/ethics-and-privacy-implications-of-using-the-internet-and-social-media-to-recruit-participants-for-health-research-a-privacy-by-design-framework-for-online-recruitment
#20
Jacqueline Lorene Bender, Alaina B Cyr, Luk Arbuckle, Lorraine E Ferris
BACKGROUND: The Internet and social media offer promising ways to improve the reach, efficiency, and effectiveness of recruitment efforts at a reasonable cost, but raise unique ethical dilemmas. We describe how we used social media to recruit cancer patients and family caregivers for a research study, the ethical issues we encountered, and the strategies we developed to address them. OBJECTIVE: Drawing on the principles of Privacy by Design (PbD), a globally recognized standard for privacy protection, we aimed to develop a PbD framework for online health research recruitment...
April 6, 2017: Journal of Medical Internet Research
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