keyword
MENU ▼
Read by QxMD icon Read
search

Global alignment

keyword
https://www.readbyqxmd.com/read/28228750/evolutionary-roots-and-diversification-of-the-genus-aeromonas
#1
Ariadna Sanglas, Vicenta Albarral, Maribel Farfán, J G Lorén, M C Fusté
Despite the importance of diversification rates in the study of prokaryote evolution, they have not been quantitatively assessed for the majority of microorganism taxa. The investigation of evolutionary patterns in prokaryotes constitutes a challenge due to a very scarce fossil record, limited morphological differentiation and frequently complex taxonomic relationships, which make even species recognition difficult. Although the speciation models and speciation rates in eukaryotes have traditionally been established by analyzing the fossil record data, this is frequently incomplete, and not always available...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28225365/magnitude-location-and-factors-related-to-regional-and-global-sagittal-alignment-change-in-long-adult-deformity-constructs-report-of-183-patients-with-2-year-follow-up
#2
Alexander A Theologis, Michael Safaee, Justin K Scheer, Virginie Lafage, Rick Hostin, Robert A Hart, Eric O Klineberg, Themistocles S Protopsaltis, Vedat Deviren, Douglas C Burton, Daniel M Sciubba, Khaled Kebaish, Shay Bess, Christopher I Shaffrey, Frank Schwab, Justin S Smith, Christopher P Ames
STUDY DESIGN: This is a retrospective review of a prospective multicenter adult spinal deformity (ASD) database. OBJECTIVE: To quantify the location and magnitude of sagittal alignment changes within instrumented and noninstrumented spinal segments and to investigate the factors associated with these changes after surgery for ASD. SUMMARY OF BACKGROUND DATA: Spinal realignment is one of the major goals in ASD surgery and changes in the alignment are common following surgical correction...
February 20, 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28219364/the-relationship-between-changes-of-cervical-sagittal-alignment-after-anterior-cervical-discectomy-and-fusion-and-spino-pelvic-sagittal-alignment-under-roussouly-classification-a-four-year-follow-up-study
#3
Dong-Ning Huang, Miao Yu, Nan-Fang Xu, Mai Li, Shao-Bo Wang, Yu Sun, Liang Jiang, Feng Wei, Xiao-Guang Liu, Zhong-Jun Liu
BACKGROUND: Anterior cervical discectomy and fusion (ACDF) is widely used in the treatment of cervical degenerative disease; however, the variation of cervical sagittal alignment changes after ACDF has been rarely explored. The purpose of this study is to determine the relationship between changes of cervical sagittal alignment after ACDF and spino-pelvic sagittal alignment under Roussouly classification. METHODS: A cohort of 133 Chinese cervical spondylotic patients who received ACDF from 2011 to 2012 was recruited...
February 20, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28216511/global-kinetoplastea-phylogeny-inferred-from-a-large-scale-multigene-alignment-including-parasitic-species-for-better-understanding-transitions-from-a-free-living-to-a-parasitic-lifestyle
#4
Euki Yazaki, Sohta A Ishikawa, Keitaro Kume, Akira Kumagai, Takashi Kamaishi, Goro Tanifuji, Tetsuo Hashimoto, Yuji Inagaki
All members of the order Trypanosomatida known to date are parasites that are most likely descendants of a free-living ancestor. Trypanosomatids are an excellent model to assess the transition from a free-living to a parasitic lifestyle, because a large amount of experimental data has been accumulated for well-studied members that are harmful to humans and livestock (Trypanosoma spp. and Leishmania spp.). However, recent advances in our understanding of the diversity of trypanosomatids and their close relatives (i...
February 20, 2017: Genes & Genetic Systems
https://www.readbyqxmd.com/read/28197404/using-global-analysis-to-extend-the-accuracy-and-precision-of-binding-measurements-with-t-cell-receptors-and-their-peptide-mhc-ligands
#5
Sydney J Blevins, Brian M Baker
In cellular immunity, clonally distributed T cell receptors (TCRs) engage complexes of peptides bound to major histocompatibility complex proteins (pMHCs). In the interactions of TCRs with pMHCs, regions of restricted and variable diversity align in a structurally complex fashion. Many studies have used mutagenesis to attempt to understand the "roles" played by various interface components in determining TCR recognition properties such as specificity and cross-reactivity. However, these measurements are often complicated or even compromised by the weak affinities TCRs maintain toward pMHC...
2017: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/28196471/characterization-and-expression-profiling-of-serine-protease-inhibitors-in-the-diamondback-moth-plutella-xylostella-lepidoptera-plutellidae
#6
Hailan Lin, Xijian Lin, Jiwei Zhu, Xiao-Qiang Yu, Xiaofeng Xia, Fengluan Yao, Guang Yang, Minsheng You
BACKGROUND: Serine protease inhibitors (SPIs) have been found in all living organisms and play significant roles in digestion, development and innate immunity. In this study, we present a genome-wide identification and expression profiling of SPI genes in the diamondback moth, Plutella xylostella (L.), a major pest of cruciferous crops with global distribution and broad resistance to different types of insecticides. RESULTS: A total of 61 potential SPI genes were identified in the P...
February 14, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28188745/pregnancy-context-and-women-s-health-related-quality-of-life
#7
Aileen Gariepy, Lisbet S Lundsberg, Nicole Vilardo, Nancy Stanwood, Kimberly Yonkers, Eleanor B Schwarz
OBJECTIVE: To quantify the association of pregnancy context and health-related quality of life (HRQoL). STUDY DESIGN: English- or Spanish-speaking women, aged 16-44, with pregnancies<24weeks gestation were enrolled in this cross-sectional study between June 2014 and June 2015. Participants completed self-assessments of pregnancy "context," including: timing, intention, wantedness, desirability, happiness, and planning (measured with the London Measure of Unplanned Pregnancy)...
February 8, 2017: Contraception
https://www.readbyqxmd.com/read/28182782/correction-donor-financing-of-global-mental-health-1995-2015-an-assessment-of-trends-channels-and-alignment-with-the-disease-burden
#8
(no author information available yet)
[This corrects the article DOI: 10.1371/journal.pone.0169384.].
2017: PloS One
https://www.readbyqxmd.com/read/28181158/longitudinal-trends-in-childbirth-practices-in-ethiopia
#9
Julianne Weis
Objectives This study examines the influence of women's birth practices on their daughters' location of childbirth in Ethiopia, investigating the importance of intergenerational patterns of care on contemporary birth practices. Methods A qualitative survey of women aged 60 and over in three cities in Ethiopia. Results Nearly all first generation women gave birth at home, but the majority of their daughters give birth in facilities. Perceptions of childbirth practices among both women and their daughters have shifted towards facility births, despite the prevalence of home birth in the previous generation...
February 8, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/28179183/re-analysis-of-unassigned-hepatitis-c-virus-hcv-strain-cyhcv025-evidence-of-a-highly-divergent-lineage-within-genotype-1
#10
M Oikonomopoulou, V L Demetriou, L G Kostrikis, D Paraskevis
HCV global sequences have been classified into 7 genotypes, several subtypes and a number of unassigned sequences. Our aim was to perform an in depth investigation of the taxonomic relationships of the unclassified CYHCV025 strain by means of phylogenetic analysis. Phylogenetic tree reconstructions were performed using ML methods on full-length genomic and partial HCV alignments. Phylogenetic analysis of full-length sequences revealed that CYHCV025 clustered close to the root node of genotype 1, showing distant genetic relationships to all previously classified subtypes and unclassified sequences...
February 4, 2017: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/28176825/uncertainties-in-the-shuttle-radar-topography-mission-srtm-heights-insights-from-the-indian-himalaya-and-peninsula
#11
Manas Mukul, Vinee Srivastava, Sridevi Jade, Malay Mukul
The Shuttle Radar Topography Mission (SRTM) Digital Terrain Elevation Data (DTED) are used with the consensus view that it has a minimum vertical accuracy of 16 m absolute error at 90% confidence (Root Mean Square Error (RMSE) of 9.73 m) world-wide. However, vertical accuracy of the data decreases with increase in slope and elevation due to presence of large outliers and voids. Therefore, studies using SRTM data "as is", especially in regions like the Himalaya, are not statistically meaningful. New data from ~200 high-precision static Global Position System (GPS) Independent Check Points (ICPs) in the Himalaya and Peninsular India indicate that only 1-arc X-Band data are usable "as is" in the Himalaya as it has height accuracy of 9...
February 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28174604/challenging-the-foundations-of-the-clinical-model-of-foot-function-further-evidence-that-the-root-model-assessments-fail-to-appropriately-classify-foot-function
#12
Hannah L Jarvis, Christopher J Nester, Peter D Bowden, Richard K Jones
BACKGROUND: The Root model of normal and abnormal foot function remains the basis for clinical foot orthotic practice globally. Our aim was to investigate the relationship between foot deformities and kinematic compensations that are the foundations of the model. METHODS: A convenience sample of 140 were screened and 100 symptom free participants aged 18-45 years were invited to participate. The static biomechanical assessment described by the Root model was used to identify five foot deformities...
2017: Journal of Foot and Ankle Research
https://www.readbyqxmd.com/read/28171754/navigation-whence-our-sense-of-direction
#13
C R Gallistel
Behavioral data have long implied our sense of direction derives from global environmental shape; electrophysiological evidence, however, has seemed to imply it derives from salient non-geometric landmarks. Experiments on the re-establishment of place fields in disoriented mice now align the electrophysiological data with the behavioral data.
February 6, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28168197/design-and-validation-of-equiaxial-mechanical-strain-platform-equicycler-for-3d-tissue-engineered-constructs
#14
Mostafa Elsaadany, Matthew Harris, Eda Yildirim-Ayan
It is crucial to replicate the micromechanical milieu of native tissues to achieve efficacious tissue engineering and regenerative therapy. In this study, we introduced an innovative loading platform, EQUicycler, that utilizes a simple, yet effective, and well-controlled mechanism to apply physiologically relevant homogenous mechanical equiaxial strain on three-dimensional cell-embedded tissue scaffolds. The design of EQUicycler ensured elimination of gripping effects through the use of biologically compatible silicone posts for direct transfer of the mechanical load to the scaffolds...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28167061/chopart-injuries-when-to-fix-and-when-to-fuse
#15
REVIEW
Stefan Rammelt, Tim Schepers
Chopart joint injuries have a profound effect on global foot function. Surgical treatment aims at joint reconstruction and axial alignment with restoration of the normal relationship of the lateral and medial foot columns. Internal fixation is tailored to the individual fracture pattern and achieved with resorbable pins, Kirschner wires, screws, and/or anatomically shaped minifragment plates. If instability persists, temporary joint transfixation may be achieved with Kirschner wires or bridge plating. Primary fusion sacrifices essential joints and should be reserved for severe initial cartilage damage...
March 2017: Foot and Ankle Clinics
https://www.readbyqxmd.com/read/28166632/metabolomics-based-elucidation-of-active-metabolic-pathways-in-erythrocytes-and-hsc-derived-reticulocytes
#16
Anubhav Srivastava, Krystal J Evans, Anna Elizabeth Sexton, Louis Schofield, Darren John Creek
A detailed analysis of the metabolic state of human stem cell derived erythrocytes allowed us to characterize the existence of active metabolic pathways in younger reticulocytes and compare them to mature erythrocytes. Using high resolution LC-MS based, untargeted metabolomics, we found that reticulocytes had a comparatively much richer repertoire of metabolites, which spanned a range of metabolite classes. An untargeted metabolomics analysis using stable isotope-labelled glucose showed that only glycolysis and the pentose phosphate pathway actively contributed to the biosynthesis of metabolites in erythrocytes, and these pathways were upregulated in reticulocytes...
February 7, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28163667/current-practice-and-perspectives-in-cro-oversight-based-on-a-survey-performed-among-members-of-the-german-association-of-research-based-pharmaceutical-companies-vfa
#17
Michael Hennig, Ferdinand Hundt, Susanne Busta, Stefan Mikus, Per-Holger Sanden, Andrea Sörgel, Thorsten Ruppert
In recent years, the number and scope of outsourced activities in the pharmaceutical industry have increased heavily. In addition, also the type of outsourcing has changed significantly in that time. This raises the question of whether and how sponsors retain the capability to select and to control the contract research organizations (CROs) involved and what expertise still has to be present in the development department as well as other relevant departments to ensure adequate oversight, also in line with the expectations of regulators and health authorities...
2017: German Medical Science: GMS E-journal
https://www.readbyqxmd.com/read/28160031/planning-for-the-maintenance-of-floristic-diversity-in-the-face-of-land-cover-and-climate-change
#18
Debbie Jewitt, Peter S Goodman, Barend F N Erasmus, Timothy G O'Connor, Ed T F Witkowski
Habitat loss and climate change are primary drivers of global biodiversity loss. Species will need to track changing environmental conditions through fragmented and transformed landscapes such as KwaZulu-Natal, South Africa. Landscape connectivity is an important tool for maintaining resilience to global change. We develop a coarse-grained connectivity map between protected areas to aid decision-making for implementing corridors to maintain floristic diversity in the face of global change. The spatial location of corridors was prioritised using a biological underpinning of floristic composition that incorporated high beta diversity regions, important plant areas, climate refugia, and aligned to major climatic gradients driving floristic pattern...
February 4, 2017: Environmental Management
https://www.readbyqxmd.com/read/28153856/death-of-outrage-over-talking-about-dying
#19
Nrupen A Bhavsar, Sara Constand, Matthew Harker, Donald H Taylor
OBJECTIVES: We examined public reaction to the proposed Center for Medicare and Medicaid Services rule reimbursing physicians for advanced care planning (ACP) discussions with patients. METHODS: Public comments made on regulations.gov were reviewed for relevance to ACP policy and their perceived position on ACP (ie, positive, negative and neutral). Descriptive statistics were used to quantify the results. RESULTS: A total of 2225 comments were submitted to regulations...
February 2, 2017: BMJ Supportive & Palliative Care
https://www.readbyqxmd.com/read/28153494/individual-differences-in-the-dynamics-of-collinear-facilitation
#20
Stephen Jachim, Emma Gowen, Paul A Warren
Collinear facilitation refers to the increase in sensitivity found for a target when aligned between nearby, brighter flankers. Many studies have explored the spatial and temporal aspects of this arrangement, and there is a consensus that two mechanisms could be responsible for this phenomenon; lateral excitation within V1 and extra-striate feedback to V1. There is some debate as to whether facilitation can still occur if the target is presented before the flankers, a manipulation known as backward masking, which could rely on feedback to V1...
February 17, 2017: Vision Research
keyword
keyword
57543
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"