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https://www.readbyqxmd.com/read/28918749/effect-of-low-temperature-on-globin-expression-respiratory-metabolic-enzyme-activities-and-gill-structure-of-litopenaeus-vannamei
#1
Meng Wu, Nan Chen, Chun-Xiao Huang, Yan He, Yong-Zhen Zhao, Xiao-Han Chen, Xiu-Li Chen, Huan-Ling Wang
Low temperature frequently influences growth, development, and even survival of aquatic animals. In the present study, physiological and molecular responses to low temperature in Litopenaeus vannamei were investigated. The cDNA sequences of two oxygen-carrying proteins, cytoglobin (Cygb) and neuroglobin (Ngb), were isolated. Protein structure analysis revealed that both proteins share a globin superfamily domain. Real-time PCR analysis indicated that Cygb and Ngb mRNA levels gradually increased during decrease in temperatures from 25 to 15°C and then decreased at 10°C in muscle, brain, stomach, and heart, except for a continuing increase in gills, whereas they showed a different expression trend in the hepatopancreas...
July 2017: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/28913435/iba57-mutations-abrogate-iron-sulfur-cluster-assembly-leading-to-cavitating-leukoencephalopathy
#2
Akihiko Ishiyama, Chika Sakai, Yuichi Matsushima, Satoru Noguchi, Satomi Mitsuhashi, Yukari Endo, Yukiko K Hayashi, Yoshiaki Saito, Eiji Nakagawa, Hirofumi Komaki, Kenji Sugai, Masayuki Sasaki, Noriko Sato, Ikuya Nonaka, Yu-Ichi Goto, Ichizo Nishino
OBJECTIVE: To determine the molecular factors contributing to progressive cavitating leukoencephalopathy (PCL) to help resolve the underlying genotype-phenotype associations in the mitochondrial iron-sulfur cluster (ISC) assembly system. METHODS: The subjects were 3 patients from 2 families who showed no inconsistencies in either clinical or brain MRI findings as PCL. We used exome sequencing, immunoblotting, and enzyme activity assays to establish a molecular diagnosis and determine the roles of ISC-associated factors in PCL...
October 2017: Neurology. Genetics
https://www.readbyqxmd.com/read/28905938/triptolide-induces-sertoli-cell-apoptosis-in-mice-via-ros-jnk-dependent-activation-of-the-mitochondrial-pathway-and-inhibition-of-nrf2-mediated-antioxidant-response
#3
Yu Wang, Su-Han Guo, Xue-Jun Shang, Li-Sha Yu, Jian-Wei Zhu, Ang Zhao, Yan-Fen Zhou, Guo-Hua An, Qi Zhang, Bo Ma
Triptolide (TP), an oxygenated diterpene, has a variety of beneficial pharmacodynamic activities but its clinical applications are restricted due to severe testicular injury. This study aimed to delineate the molecular mechanisms of TP-induced testicular injury in vitro and in vivo. TP (5-50000 nmol/L) dose-dependently decreased the viability of TM4 Sertoli cells with an IC50 value of 669.5-269.45 nmol/L at 24 h. TP (125, 250, and 500 nmol/L) dose-dependently increased the accumulation of ROS, the phosphorylation of JNK, mitochondrial dysfunction and activation of the intrinsic apoptosis pathway in TM4 cells...
September 14, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28900423/esre-a-yigp-locus-encoded-transcript-is-a-3-utr-srna-involved-in-the-respiratory-chain-of-e-coli
#4
Hui Xia, Xichen Yang, Qiongwei Tang, Jiang Ye, Haizhen Wu, Huizhan Zhang
The yigP locus is widely conserved among γ-proteobacteria. Mutation of the yigP locus impacts aerobic growth of Gram-negative bacteria. However, the underlying mechanism of how the yigP locus influences aerobic growth remains largely unknown. Here, we demonstrated that the yigP locus in Escherichia coli encodes two transcripts; the mRNA of ubiquinone biosynthesis protein, UbiJ, and the 3' untranslated region small regulatory RNA (sRNA), EsrE. EsrE is an independent transcript that is transcribed using an internal promoter of the yigP locus...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28898443/re-evaluation-of-33-unclassified-eosinophilic-renal-cell-carcinomas-in-young-patients
#5
Yunjie Li, Victor E Reuter, Andres Matoso, George J Netto, Jonathan I Epstein, Pedram Argani
AIMS: We sought to determine if some unclassified renal cell carcinomas (RCCs) in children and young adults that are characterized by predominantly eosinophilic cytoplasm are related to the recently described succinate dehydrogenase (SDH)-deficient RCC, fumarate hydratase (FH)-deficient RCC, or eosinophilic solid and cystic (ESC) RCC. METHODS AND RESULTS: We reviewed 33 unclassified RCCs with predominantly eosinophilic cytoplasm in patients age 35 years or younger...
September 12, 2017: Histopathology
https://www.readbyqxmd.com/read/28895554/anomalous-cyclotron-mass-dependence-on-the-magnetic-field-and-berry-s-phase-in-cd-sub-1-x-y-sub-zn-sub-x-sub-mn-sub-y-sub-sub-3-sub-as-sub-2-sub-solid-solutions
#6
Vasilii S Zakhvalinskii, Tatyana Nikulicheva, Erkki Lähderanta, Mikhail A Shakhov, Ekaterina Nikitovskaya, Sergey Taran
Shubnikov-de Haas (SdH) effect and magnetoresistance measurements of single crystals of diluted II-V magnetic semiconductors (Cd<sub>1-x-y</sub>Zn<sub>x</sub>Mn<sub>y</sub>)<sub>3</sub>As<sub>2</sub> (x + y = 0.4, y = 0.04 and 0.08) are investigated in the temperature range T = 4.2 ÷ 300 K and in transverse magnetic field B = 0 ÷ 25 T. The values of the cyclotron mass m<sub>c</sub>, the effective g-factor g*, and the Dingle temperature T<sub>D</sub> are defined...
September 12, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28889182/benign-extracerebral-fluid-collection-complicated-by-subdural-hematoma-and-fluid-collection-clinical-characteristics-and-management
#7
Hee Chang Lee, Sangjoon Chong, Ji Yeoun Lee, Jung-Eun Cheon, Ji Hoon Phi, Seung-Ki Kim, In-One Kim, Kyu-Chang Wang
INTRODUCTION: Benign extracerebral fluid collection (bECFC) can be complicated by subdural hematoma (SDH) or subdural fluid collection (SDFC). The etiology, natural history, and management strategy for SDH/SDFC in bECFC are not fully understood. We retrospectively reviewed the cases of bECFC patients complicated with SDH/SDFC and tried (1) to confirm the fact that bECFC children are vulnerable to SDH/SDFC, (2) to investigate the clinical significance of 'trauma history' witnessed by a caregiver, and (3) to determine optimal management for them...
September 9, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28887078/management-of-residual-subdural-hematoma-after-burr-hole-evacuation-the-role-of-fluid-therapy-and-review-of-the-literature
#8
Nicola Montano, Vito Stifano, Benjamin Skrap, Edoardo Mazzucchi
A vast amount of literature has been published investigating the factors associated to the recurrence of a chronic subdural hematoma (SDH). However, little exists in the literature about the best medical management of the residual SDH in order to prevent the recurrence. Moreover only few studies quantitatively assess clinical and radiological outcomes of residual post-operative SDH. In this study, to our knowledge, we report the first series of chronic SDH with a quantitative outcomes analysis of the effects of fluid therapy on residual post-operative SDH...
September 5, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28877598/resident-documentation-of-social-determinants-of-health-effects-of-a-teaching-tool-in-the-outpatient-setting
#9
Milani Patel, Eleanor Bathory, Jenna Scholnick, Tanya White-Davis, Jaeun Choi, Sandra Braganza
Social determinants of health (SDH) significantly affect the health of children and thus, screening is important in pediatric primary care. We assessed the use of a formal social history taking tool after a 2-phase intervention. The first phase (P1) was a teaching module describing SDH and community resources and the second phase (P2) consisted of visual reminders to use the tool. Patient charts (n = 322) were reviewed pre- and postintervention. Residents had higher documentation rates of Women, Infants, and Children (WIC) program use and housing subsidies at post-P1 and at post-P(1 + 2) (WIC, P = ...
September 1, 2017: Clinical Pediatrics
https://www.readbyqxmd.com/read/28871614/a-decision-instrument-to-identify-isolated-traumatic-subdural-hematomas-at-low-risk-of-neurological-deterioration-surgical-intervention-or-radiographic-worsening
#10
Peter Pruitt, Jonathan Van Ornam, Pierre Borczuk
BACKGROUND AND OBJECTIVES: Subdural hematoma (SDH) is the most common form of traumatic intracranial hemorrhage. Severity of disease in patients with SDH varies widely. It was hypothesized that a decision rule could identify patients with SDH who are at very low-risk for neurological decline, neurosurgical intervention or radiographic worsening. METHODS: Retrospective chart review of consecutive patients age ≥ 16 with Glasgow Coma Score (GCS) ≥ 13 and CT-documented isolated SDH presenting to a university affiliated, urban, 100,000-annual-visit ED from 2009-2015...
September 4, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/28868305/vertebroplasty-and-delayed-subdural-cauda-equina-hematoma-review-of-literature-and-case-report
#11
Maria Pia Tropeano, Biagia La Pira, Lorenzo Pescatori, Manolo Piccirilli
Vertebroplasy is considered an alternative and effective treatment of painful oncologic spine disease. Major complications are very rare, but with high morbidity and occur in less than 1% of patients who undergo vertebroplasty. Spinal subdural hematoma (SDH) is an extremely rare complication, usual developing within 12 h to 24 h after the procedure. We report the case of a tardive SDH in an oncologic patient who underwent VP for Myxoid Liposarcoma metastasis. Trying to explain the pathogenesis, we support the hypothesis that both venous congestion of the vertebral venous plexus of the vertebral body and venous congestion due to a traumatic injury can provoke SDH...
August 16, 2017: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/28867312/models-of-mortality-and-morbidity-in-severe-traumatic-brain-injury-an-analysis-of-a-singapore-neurotrauma-database
#12
Julian Xinguang Han, Angela An Qi See, Mihir Gandhi, Nicolas Kon Kam King
OBJECTIVE: Current prognostic models for traumatic brain injury (TBI) available for use are developed from diverse historical datasets. We aim to construct a prognostication tool for severe TBI as it is this group who would benefit the most from an accurate model. METHODS: Model development was based on a cohort of 300 patients with severe TBI (Glasgow Coma Score [GCS] ≤ 8) consecutively admitted to a neurosurgical intensive care unit in the National Neuroscience Institute (NNI), Singapore, between February 2006 and December 2009...
August 31, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28865472/doctoral-level-research-and-training-capacity-in-the-social-determinants-of-health-at-universities-and-higher-education-institutions-in-india-china-oman-and-vietnam-a-survey-of-needs
#13
Farhad Ali, Arun Shet, Weirong Yan, Abdullah Al-Maniri, Salla Atkins, Henry Lucas
BACKGROUND: Research capacity is scarce in low- and middle-income country (LMIC) settings. Social determinants of health research (SDH) is an area in which research capacity is lacking, particularly in Asian countries. SDH research can support health decision-makers, inform policy and thereby improve the overall health and wellbeing of the population. In order to continue building this capacity, we need to know to what extent training exists and how challenges could be addressed from the perspective of students and staff...
September 2, 2017: Health Research Policy and Systems
https://www.readbyqxmd.com/read/28862149/electrical-and-thermoelectric-transport-properties-of-two-dimensional-fermionic-systems-with-i-k-i-cubic-spin-orbit-coupling
#14
Alestin Mawrie, Sonu Verma, Tarun Kanti Ghosh
We investigate effect of <i>k</i>-cubic spin-orbit interaction on electrical and thermoelectric transport properties of two-dimensional fermionic systems. We obtain exact analytical expressions of the inverse relaxation time (IRT) and the Drude conductivity for long-range Coulomb and short-range delta scattering potentials. The IRT reveals that the scattering is completely suppressed along the three directions θ = (2n+1)π/3 with n=1,2,3. We also obtain analytical results of the thermopower and thermal conductivity at low temperature...
September 1, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28855235/evaluation-of-a-novel-germline-tmem127-mutation-in-an-uncommon-presentation
#15
Yilun Deng, Shahida K Flores, Zi-Ming Cheng, Yuejuan Qin, Robin C Schwartz, Carl D Malchoff, Patricia Dahia
Germline mutations of the endomembrane-encoding gene TMEM127 confers susceptibility to neural crest-derived tumors pheochromocytomas (PHEOs) and have also been found in isolated renal cell carcinomas (RCCs). PHEOs and RCCs can arise as a result of shared inherited susceptibility, as in von Hippel Lindau disease and in PHEO-paraganglioma syndromes related to mutations in succinate dehydrogenase (SDH) subunit genes. The clinical spectrum and the signaling consequences of TMEM127 mutations remain poorly defined and it is not clear whether both tumors can be associated in families...
August 30, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/28853707/physics-of-srtio-sub-3-sub-based-heterostructures-and-nanostructures-a-review
#16
Yun-Yi Pai, Anthony Tylan-Tyler, Patrick Irvin, Jeremy Levy
1 Overview 1 1.1 Introduction 1 1.1.1 Oxide growth techniques are rooted in search for high-Tc superconductors 2 1.1.2 First reports of interface conductivity 2 1.2 2D physics 2 1.3 Emergent properties of oxide heterostructures and nanostructures 3 1.4 Outline 3 2 Relevant properties of SrTiO3 3 2.1 Structural properties and transitions 3 2.2 Ferroelectricity, Paraelectricity and Quantum Paraelectricity 4 2.3 Electronic structure 5 2.4 Defects 6 2...
August 30, 2017: Reports on Progress in Physics
https://www.readbyqxmd.com/read/28844004/altered-intrinsic-and-synaptic-properties-of-lumbosacral-dorsal-horn-neurons-in-a-mouse-model-of-colitis
#17
Kristen E Farrell, Simon Keely, Marjorie M Walker, Alan M Brichta, Brett A Graham, Robert J Callister
Visceral pain in inflammatory and functional gastrointestinal conditions is a major clinical problem. The exact mechanisms underlying the development of pain, during and after visceral inflammation are unknown. However, clinical and pre-clinical evidence suggests plasticity within the spinal cord dorsal horn is a contributing factor. Here we use an in vivo preparation and patch-clamp electrophysiology to test whether the synaptic and intrinsic properties of superficial dorsal horn (SDH) neurons are altered 5days after the induction of mild colitis in adult male mice (i...
August 23, 2017: Neuroscience
https://www.readbyqxmd.com/read/28840584/metabolic-enzymes-in-sarcomagenesis-progress-toward-biology-and-therapy
#18
Luyuan Li, Josiane E Eid, Ana C Paz, Jonathan C Trent
Cellular metabolism reprogramming is an emerging hallmark of cancer, which provides tumor cells with not only necessary energy but also crucial materials to support growth. Exploiting the unique features of cancer metabolism is promising in cancer therapies. The growing interest in this field has led to numerous inhibitors being developed against key molecules in metabolic pathways, though most of them are still in preclinical development. Potential targeted cancer cell metabolic pathways under investigation include glycolysis, tricarboxylic acid (TCA) cycle, oxidative phosphorylation (OXPHOS), glutaminolysis, pentose phosphate pathway (PPP), lipid synthesis, amino acid and nucleotide metabolism...
August 24, 2017: BioDrugs: Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
https://www.readbyqxmd.com/read/28840535/chronic-exposure-to-%C3%AE-alanine-generates-oxidative-stress-and-alters-energy-metabolism-in-cerebral-cortex-and-cerebellum-of-wistar-rats
#19
Tanise Gemelli, Rodrigo Binkowski de Andrade, Denise Bertin Rojas, Ângela Zanatta, Gabriel Henrique Schirmbeck, Cláudia Funchal, Moacir Wajner, Carlos Severo Dutra-Filho, Clovis Milton Duval Wannmacher
β-Alanine occurs naturally in the human central nervous system and performs different functions. It can act as either a neurotransmitter or a neuromodulator, depletion of taurine levels and competitive antagonist of γ-aminobutyric acid (GABA). The β-amino acid accumulation exerts an important biological function as delay in brain development, oxidative stress and disturbances in energy metabolism, characterized as an inborn error of metabolism classified as β-alaninemia. We evaluated the effects of the chronic administration of β-alanine on some parameters of oxidative stress and enzymes of energy metabolism in cerebral cortex and cerebellum of 21-day-old Wistar rats...
August 24, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28828276/pyrrolizidine-alkaloid-variation-in-senecio-vulgaris-populations-from-native-and-invasive-ranges
#20
Dandan Cheng, Viet-Thang Nguyen, Noel Ndihokubwayo, Jiwen Ge, Patrick P J Mulder
Biological invasion is regarded as one of the greatest environmental problems facilitated by globalization. Some hypotheses about the invasive mechanisms of alien invasive plants consider the plant-herbivore interaction and the role of plant defense in this interaction. For example, the "Shift Defense Hypothesis" (SDH) argues that introduced plants evolve higher levels of qualitative defense chemicals and decreased levels of quantitative defense, as they are released of the selective pressures from specialist herbivores but still face attack from generalists...
2017: PeerJ
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