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https://www.readbyqxmd.com/read/29783009/antiplatelet-medication-reversal-strategies-in-operative-intracranial-hemorrhage-a-survey-of-practicing-neurosurgeons
#1
Paul M Foreman, Adeel Ilyas, James Mooney, Philip G R Schmalz, Beverly C Walters, Christoph J Griessenauer
OBJECTIVE: Antiplatelet therapy is common and complicates the operative management of acute intracranial hemorrhage. Little data exist to guide antiplatelet reversal strategies. METHODS: An online survey detailing antiplatelet reversal strategies in patients presenting with acute operative intracranial hemorrhage (subdural hematoma (SDH), epidural hematoma (EDH), and intracerebral hemorrhage (ICH) was distributed to board certified neurosurgeons in the North America...
May 18, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29778095/establishing-an-innovative-carbohydrate-metabolic-pathway-for-efficient-production-of-2-keto-l-gulonic-acid-in-ketogulonicigenium-robustum-initiated-by-intronic-promoters
#2
Cai-Yun Wang, Ye Li, Zi-Wei Gao, Li-Cheng Liu, Meng-Yue Zhang, Tian-Yuan Zhang, Chun-Fu Wu, Yi-Xuan Zhang
BACKGROUND: 2-Keto-L-gulonic acid (2-KGA), the precursor of vitamin C, is currently produced by two-step fermentation. In the second step, L-sorbose is transformed into 2-KGA by the symbiosis system composed of Ketogulonicigenium vulgare and Bacillus megaterium. Due to the different nutrient requirements and the uncertain ratio of the two strains, the symbiosis system significantly limits strain improvement and fermentation optimization. RESULTS: In this study, Ketogulonicigenium robustum SPU_B003 was reported for its capability to grow well independently and to produce more 2-KGA than that of K...
May 19, 2018: Microbial Cell Factories
https://www.readbyqxmd.com/read/29773517/astrocytic-ca-2-responses-in-the-spinal-dorsal-horn-by-noxious-stimuli-to-the-skin
#3
Kohei Yoshihara, Tsuyoshi Matsuda, Yuta Kohro, Hidetoshi Tozaki-Saitoh, Kazuhide Inoue, Makoto Tsuda
The role of astrocytes in the spinal dorsal horn (SDH) for sensory information processing under normal conditions is poorly understood. In this study, we investigated whether SDH astrocytes respond to noxious and innocuous stimuli to the skin of normal mice using in vivo two-photon Ca2+ imaging under anesthesia. We found that noxious stimulation evoked by intraplantar formalin injection provoked an elevation in intracellular Ca2+ levels in SDH astrocytes. By contrast, neither instantaneous noxious pinching nor innocuous stimuli (cooling or brushing) to the hindpaw elicited astrocytic Ca2+ responses...
May 3, 2018: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/29770777/shubnikov-de-haas-oscillations-in-i-p-i-and-i-n-i-type-topological-insulator-bi-sub-x-sub-sb-sub-1-x-sub-sub-2-sub-te-sub-3-sub
#4
Ryota Akiyama, Kazuki Sumida, Satoru Ichinokura, Ryosuke Nakanishi, Akio Kimura, Konstantin A Kokh, Oleg Tereshchenko, Shuji Hasegawa
We show Shubnikov-de Haas (SdH) oscillations in topological insulator (Bi<sub>x</sub>Sb<sub>1-x</sub>)<sub>2</sub>Te<sub>3</sub> flakes whose carrier types are <i>p</i>-type (<i>x</i> = 0.29, 0.34) and <i>n</i>-type (<i>x</i> = 0.42). The physical properties such as the Berry phase, carrier mobility, and scattering time significantly changed by tuning the Fermi-level position with the concentration <i>x</i>...
May 17, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29770666/-molluscicidal-effect-and-mechanism-of-action-of-niclosamidate-against-oncomelania-hupensis
#5
Luo Bing-Rong, Yao Jun-Min, Wang Wei-Si, Li Shi-Zhu, Yang Jing, Chen Shao-Rong, Luo Jia-Jun, Liu Yu-Hua, Duan Li-Ping
OBJECTIVE: To evaluate the molluscicidal effect of niclosamidate against Oncomelania hupensis in laboratory and explore its mechanism by determining the enzyme activities of six important enzymes in snail soft tissues. METHODS: O. hupensis snails were treated with niclosamidate at the concentration of 1.25 mg/L for 24 h and the snail soft tissues were separated and prepared for analysis. The enzyme activities of NOS, AChE, SDH, LDH, ACP and AKP were determined by ultraviolet spectrophotometry...
February 10, 2018: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
https://www.readbyqxmd.com/read/29749036/differential-mrna-expression-of-neuroinflammatory-modulators-in-the-spinal-cord-and-thalamus-of-type-2-diabetic-monkeys
#6
Huiping Ding, Norikazu Kiguchi, Shiroh Kishioka, Tao Ma, Christopher M Peters, Mei-Chuan Ko
BACKGROUND: Given that diabetes-associated complications are closely associated with neuroinflammation, it is imperative to study potential changes in neuroinflammatory modulators in the central nervous system of diabetic primates. METHODS: The mRNA levels of pro-inflammatory and anti-inflammatory cytokines, toll-like receptors (TLR), growth factors, and cannabinoid receptors were compared in the spinal dorsal horn (SDH) and thalamus of naturally occurring type 2 diabetic monkeys and an age-matched control group using reverse transcription and quantitative real-time polymerase chain reaction...
May 11, 2018: Journal of Diabetes
https://www.readbyqxmd.com/read/29746885/curcumin-inhibits-hepatic-stellate-cell-activation-via-suppression-of-succinate-associated-hif-1%C3%AE-induction
#7
Linlin She, Dan Xu, Zixia Wang, Yirui Zhang, Qingli Wei, Jiye Aa, Guangji Wang, Baolin Liu, Yuan Xie
PURPOSE: Aberrant succinate accumulation emerges as a unifying mechanism for inflammation and oxidative stress. This study aims to investigate whether curcumin ameliorates hepatic fibrosis via blocking succinate signaling. METHODS: We investigated the effects of curcumin on hepatic succinate accumulation and liver fibrosis in mice fed a high-fat diet (HFD). Meanwhile, we stimulated mouse primary hepatic stellate cells (HSCs) with succinate and observed the inhibitory effects of curcumin on succinate signaling...
May 7, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29740504/epidural-abscess-presenting-as-severe-depression-with-suicidal-ideations-case-report
#8
Erin D'Agostino, Vyacheslav Makler, David F Bauer
Background: Epidural abscess (EDA) is an uncommon form of intracranial infection that generally presents with fever, headache, and focal neurologic deficit. Imaging generally reveals a lentiform collection with diffusion restriction on diffusion weighted image. We present an interesting case in which a patient with EDA presented with three weeks of depression with suicidal ideations. The patient displayed no notable infectious signs and the imaging was suggestive of chronic subdural hematoma (SDH) rather than EDA...
2018: Surgical Neurology International
https://www.readbyqxmd.com/read/29729543/craniotomy-for-subdural-hematoma-after-deep-brain-stimulation-surgery-outcomes-and-satisfaction-in-a-case-series-of-two-patients
#9
Gordon Mao, Michael J Gigliotti, Cindy Angle, Donald Whiting, Nestor Tomycz
OBJECTIVE: To determine whether salvage of DBS hardware is beneficial for Parkinson's Disease (PD) patients by looking at follow-up patient's outcomes and satisfaction after their craniotomy operation. PATIENTS AND METHODS: This was a retrospective review of a prospective, single-center deep brain stimulation (DBS) database between 2002-2016 identifying patients with PD who developed subdural hematomas (SDH) due to trauma after their DBS surgery. Of the 636 DBS cases that were performed, 3 PD-DBS patients with significant traumatic SDH managed via craniotomy were identified...
April 27, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29729330/paraoxonase-2-prevents-the-development-of-heart-failure
#10
Wei Li, David Kennedy, Zhili Shao, Xi Wang, Andre Klaassen Kamdar, Malory Weber, Kayla Mislick, Kathryn Kiefer, Rommel Morales, Brendan Agatisa-Boyle, Diana M Shih, Srinivasa T Reddy, Christine S Moravec, W H Wilson Tang
BACKGROUND: Mitochondrial oxidation is a major source of reactive oxygen species (ROS) and mitochondrial dysfunction plays a central role in development of heart failure (HF). Paraoxonase 2 deficient (PON2-def) mitochondria are impaired in function. In this study, we tested whether PON2-def aggravates HF progression. METHODS AND RESULTS: Using qPCR, immunoblotting and lactonase activity assay, we demonstrate that PON2 activity was significantly decreased in failing hearts despite increased PON2 expression...
May 2, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29723522/transcriptomic-profiling-of-trigeminal-nucleus-caudalis-and-spinal-cord-dorsal-horn
#11
Lisette J A Kogelman, Rikke Elgaard-Christensen, Jes Olesen, Inger Jansen-Olesen, Thomas F Hansen
The pain sensation system is highly conserved among species, thus animal models have been used to investigate relevant tissues. The focus for head-specific pain has been on the primary nociceptive neurons in the trigeminal pathway, i.e. trigeminal ganglia. The secondary nociceptive neurons of the trigeminal pathway, trigeminal nucleus caudalis (TNC), have not been assessed. We expect different gene expression profiles compared to the homologous spinal cord dorsal horn (SDH), as several signalling substances provoke head-specific pain but not peripheral pain...
April 30, 2018: Brain Research
https://www.readbyqxmd.com/read/29720834/comparison-of-bran-processed-and-crude-atractylodes-lancea-effects-on-spleen-deficiency-syndrome-in-rats
#12
Dong-Hua Xue, Yu-Qiang Liu, Qian Cai, Ke Liang, Bing-Yuan Zheng, Fang-Xiao Li, Xue Pang
Background: The rhizome of Atractylodes lancea (AL) is usually used for the treatment of various diseases such as spleen deficiency syndrome (SDS). Both bran-processed and crude AL is included in Chinese Pharmacopoeia. The different efficacies of bran-processed and crude AL on SDS are largely unknown, and the mechanisms of AL effects have not been fully elucidated. Objective: The objective of the study was to compare the effects of bran-processed and crude AL and then assess the mechanisms of treating SDS...
April 2018: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29720020/middle-meningeal-artery-embolization-for-chronic-subdural-hematoma-endovascular-technique-and-radiographic-findings
#13
Thomas W Link, Benjamin I Rapoport, Stephanie M Paine, Hooman Kamel, Jared Knopman
Background and purpose Embolization of the middle meningeal artery (MMA) has recently been proposed as an alternative to surgery for treatment of chronic subdural hematoma (SDH), and several case reports have been published supporting its efficacy. It has been suggested that the primary pathologic process in chronic SDH is repeated microhemorrhaging into the subdural collection from fragile neovasculature within the SDH membrane that arises from distal branches of the MMA. Embolization could thus provide a means of eliminating this chronic rebleeding...
January 1, 2018: Interventional Neuroradiology
https://www.readbyqxmd.com/read/29717160/transcriptional-profiling-of-somatostatin-interneurons-in-the-spinal-dorsal-horn
#14
Alexander Chamessian, Michael Young, Yawar Qadri, Temugin Berta, Ru-Rong Ji, Thomas Van de Ven
The spinal dorsal horn (SDH) is comprised of distinct neuronal populations that process different somatosensory modalities. Somatostatin (SST)-expressing interneurons in the SDH have been implicated specifically in mediating mechanical pain. Identifying the transcriptomic profile of SST neurons could elucidate the unique genetic features of this population and enable selective analgesic targeting. To that end, we combined the Isolation of Nuclei Tagged in Specific Cell Types (INTACT) method and Fluorescence Activated Nuclei Sorting (FANS) to capture tagged SST nuclei in the SDH of adult male mice...
May 1, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29698879/use-of-pipeline%C3%A2-embolization-device-for-the-treatment-of-traumatic-intracranial-pseudoaneurysms-case-series-and-review-of-cases-from-literature
#15
Mairaj T Sami, Domenico A Gattozzi, Hesham M Soliman, Alan R Reeves, Christopher J Moran, Paul J Camarata, Koji C Ebersole
OBJECTIVE: Intracranial traumatic pseudoaneurysms (PSA) are a rare but dangerous subtype of cerebral aneurysm. Reports documenting use of flow-diverting stents to treat traumatic intracranial PSAs are few and lack long-term follow-up. To our knowledge, this is the largest case-series to date demonstrating use of Pipeline Endovascular Device (PED) for traumatic intracranial PSAs. PATIENTS AND METHODS: Retrospective review of 8 intracranial traumatic PSAs in 7 patients treated using only PED placement...
June 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29695583/relevance-of-abusive-head-trauma-to-intracranial-hemorrhages-and-bleeding-disorders
#16
James D Anderst, Shannon L Carpenter, Rodney Presley, Molly Curtin Berkoff, Allison P Wheeler, Robert F Sidonio, J Michael Soucie
BACKGROUND: Bleeding disorders and abusive head trauma (AHT) are associated with intracranial hemorrhage (ICH), including subdural hemorrhage (SDH). Because both conditions often present in young children, the need to screen for bleeding disorders would be better informed by data that include trauma history and are specific to young children. The Universal Data Collection database contains information on ICH in subjects with bleeding disorders, including age and trauma history. Study objectives were to (1) characterize the prevalence and calculate the probabilities of any ICH, traumatic ICH, and nontraumatic ICH in children with congenital bleeding disorders; (2) characterize the prevalence of spontaneous SDH on the basis of bleeding disorder; and (3) identify cases of von Willebrand disease (vWD) that mimic AHT...
April 25, 2018: Pediatrics
https://www.readbyqxmd.com/read/29694159/rules-for-phase-shifts-of-quantum-oscillations-in-topological-nodal-line-semimetals
#17
Cequn Li, C M Wang, Bo Wan, Xiangang Wan, Hai-Zhou Lu, X C Xie
Nodal-line semimetals are topological semimetals in which band touchings form nodal lines or rings. Around a loop that encloses a nodal line, an electron can accumulate a nontrivial π Berry phase, so the phase shift in the Shubnikov-de Haas (SdH) oscillation may give a transport signature for the nodal-line semimetals. However, different experiments have reported contradictory phase shifts, in particular, in the WHM nodal-line semimetals (W=Zr/Hf, H=Si/Ge, M=S/Se/Te). For a generic model of nodal-line semimetals, we present a systematic calculation for the SdH oscillation of resistivity under a magnetic field normal to the nodal-line plane...
April 6, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29690663/-expression-of-succinate-dehydrogenase-subunit-protein-in-succinate-dehydrogenase-deficient-gastrointestinal-stromal-tumors
#18
Y J Zhang, Y H Cheng, L X Guo, N Q Wang, H Liu
Objective: To investigate the expression of succinate dehydrogenase complex subunit protein in succinate dehydrogenase-deficient gastrointestinal stromal tumors (SDH-deficient GISTs). Methods: Three hundred fifty-two cases of GISTs were collected from January 2003 to January 2017 at the Affiliated Hospital of Guizhou Medical University and West China Hospital of Sichuan University.The expression of succinate dehydrogenase subunit protein was detected by immunohistochemical EnVision technique in 352 cases of GISTs, and the negative cases were analyzed for clinicopathologic features and outcome...
April 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29687413/protective-effect-of-apigenin-on-acrylonitrile-induced-inflammation-and-apoptosis-in-testicular-cells-via-the-nf-%C3%AE%C2%BAb-pathway-in-rats
#19
Yuhui Dang, Zhilan Li, Qian Wei, Ruiping Zhang, Hongli Xue, Yingmei Zhang
Apigenin (AP) as a plant flavonoid is found to attenuate acrylonitrile (ACN) toxicity by reducing ROS production and inhibiting apoptosis. Therefore, the present study aimed to evaluate the role of AP on ACN-induced inflammation and apoptosis in germ cells and whether it is through the NF-κB signaling pathway. AP increased the concentrations of lactate dehydrogenase isozyme (LDH) and sorbitol dehydrogenase (SDH), while the concentrations of interleukin β (IL-1β), tumor-necrosis factor-α (TNF-α), and interleukin-6 (IL-6) were significantly reduced...
April 23, 2018: Inflammation
https://www.readbyqxmd.com/read/29686819/revisiting-the-peculiar-regional-distribution-of-muscle-fiber-types-in-rat-sternomastoid-muscle
#20
Barbara Ravara, Valerio Gobbo, Damiana Incendi, Andrea Porzionato, Veronica Macchi, Raffaele De Caro, Dario Coletti, Tiziana Martinello, Marco Patruno
The sternomastoid (SM) muscle in rodents is known to have a peculiar distribution of fiber types with a steep gradient from surface to deep region. We here further characterize this peculiar regional distribution by quantitative histochemical morphometrys. In Hematoxylin-Eosin (H-E) stained transverse cryosections harvested in the medial portion of the muscle we counted around 10.000 myofibers with a mean diameter of 51.3±12.6 (μm). Cryisections of the SM stained by SDH reaction clearly show two distinct regions, toward the deep surface of the muscle a 40% area that contains packed SDH-positive myofibers, while the remaining area of the SM toward the external surface presents a more checker-board appearance...
January 12, 2018: European Journal of Translational Myology
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