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https://www.readbyqxmd.com/read/28325461/neurocritical-care-of-acute-subdural-hemorrhage
#1
REVIEW
Fawaz Al-Mufti, Stephan A Mayer
Although urgent surgical hematoma evacuation is necessary for most patients with subdural hematoma (SDH), well-orchestrated, evidenced-based, multidisciplinary, postoperative critical care is essential to achieve the best possible outcome. Acute SDH complicates approximately 11% of mild to moderate traumatic brain injuries (TBIs) that require hospitalization, and approximately 20% of severe TBIs. Acute SDH usually is related to a clear traumatic event, but in some cases can occur spontaneously. Management of SDH in the setting of TBI typically conforms to the Advanced Trauma Life Support protocol with airway taking priority, and management breathing and circulation occurring in parallel rather than sequence...
April 2017: Neurosurgery Clinics of North America
https://www.readbyqxmd.com/read/28324028/a-duodenal-sdh-deficient-gastrointestinal-stromal-tumor-in-a-patient-with-a-germline-sdhb-mutation
#2
M S Elston, S Sehgal, M Dray, E Phillips, J V Conaglen, R J Clifton-Bligh, A J Gill
Context: Gastrointestinal Stromal Tumors (GISTs) are mesenchymal tumors of the gastrointestinal tract arising from the interstitial cells of Cajal. Succinate dehydrogenase (SDH) deficient GISTs are a unique class of GIST defined by: loss of immunohistochemical expression of SDHB indicating dysfunction of the mitochondrial complex 2, lack of driver mutations in KIT and PDGFRA, and a distinctive morphology and natural history. To date, all reported SDH-deficient GISTs have arisen in the stomach...
March 15, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28322842/simultaneous-blockade-of-nmda-receptors-and-parp-1-activity-synergistically-alleviate-immunoexcitotoxicity-and-bioenergetics-in-3-nitropropionic-acid-intoxicated-mice-evidences-from-memantine-and-3-aminobenzamide-interventions
#3
Saravana Babu Chidambaram, Ranju Vijayan, Sathiya Sekar, Sugumar Mani, Barathidsan Rajamani, Ramakrishnan Ganapathy
Interlink between excitotoxicity and cellular bioenergetics depletion is implicated as one of the central deteriorative pathways in many neurodegenerative diseases including Huntington's disease (HD). Chronic administration of 3-nitropropionic acid (3-NP) depletes ATP and NAD(+;) and increases TNFα, IL-6 and glutamate content resulting in "immunoexcitotoxicity". Present study was designed to determine whether the combination of memantine (MN) and 3-aminobenzamide (3-AB), PARP inhibitor, can ameliorate immunoexcitotoxicity and improve bioenergetics in a better manner than individual administration against 3-NP intoxication in mice...
March 16, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28321772/paragangliomas-of-the-head-and-neck-an-overview-from-diagnosis-to-genetics
#4
Michelle D Williams
Paragangliomas (PGL) develop from the parasympathetic system in the head and neck (HN) and arise primarily in four distinct areas: Carotid body, vagal, middle ear, and larynx. Globally, the diagnosis and morphologic features are the same regardless of anatomic site, however the incidence, frequency of genetic alterations/syndromes and differential diagnosis vary. It is now recognized that nearly 40% of all HN PGLs are hereditary, including a significant subset without a known family history. Now pathologists are central to the evaluation for diagnosis and further management of patients with HNPGLs...
March 20, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28315797/craniotomy-versus-decompressive-craniectomy-for-acute-subdural-hematoma-systematic-review-and-meta-analysis
#5
Kevin Phan, Justin M Moore, Christoph Griessenauer, Adam A Dmytriw, Daniel B Scherman, Sharaf Sheik-Ali, Nimer Adeeb, Christopher S Ogilvy, Ajith Thomas, Jeffrey V Rosenfeld
INTRODUCTION: Acute subdural hematoma (SDH) is a major cause of morbidity following severe traumatic brain injury. Surgical evacuation of the hematoma, either via craniotomy or craniectomy, is the mainstay of treatment in patients with progressive neurological deficits or significant mass effect. However, the decision between either procedure remains controversial. METHODS: A literature search using major online databases and a manual search of reference on the topic of craniotomy and craniectomy for evacuation of subdural hematoma until September 2016 was performed...
March 15, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28303203/a-case-of-acute-subdural-hematoma-due-to-bleeding-from-metastatic-chondrosarcoma-of-the-skull
#6
Kenzo Kosugi, Satoshi Takahashi, Hikaru Sasaki, Ryota Tamura, Kentaro Ohara, Kazunari Yoshida
BACKGROUND: Intra or peritumoral hemorrhage of brain and skull tumors sometimes presents as stroke. Skull metastasis of chondrosarcoma is relatively rare, and furthermore, a case of intratumoural hemorrhage of skull metastasis of chondrosarcoma has not been reported. CASE DESCRIPTION: A 73-year-old man underwent right lower leg amputation in the past because of chondrosarcoma and was operated for a skull metastasis. He presented with a sudden headache, and head computed tomography revealed a right acute subdural hematoma (SDH) adjacent to the recurrent skull metastatic tumor...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28291625/systolic-diastolic-hypertension-versus-isolated-systolic-hypertension-and-incident-heart-failure-in-older-adults-insights-from-the-cardiovascular-health-study
#7
Apostolos Tsimploulis, Helen M Sheriff, Phillip H Lam, Daniel J Dooley, Markus S Anker, Vasilios Papademetriou, Ross D Fletcher, Charles Faselis, Gregg C Fonarow, Prakash Deedwania, Michel White, Miroslava Valentova, Marc R Blackman, Maciej Banach, Charity J Morgan, Kannayiram Alagiakrishnan, Richard M Allman, Wilbert S Aronow, Stefan D Anker, Ali Ahmed
BACKGROUND: Isolated systolic hypertension (ISH) is common in older adults and is a risk factor for incident heart failure (HF). We examined the association of systolic-diastolic hypertension (SDH) with incident HF and other outcomes in older adults. METHODS: In the Cardiovascular Health Study (CHS), 5776 community-dwelling adults≥65years had data on baseline systolic and diastolic blood pressure (SBP and DBP). We excluded those with DBP<60mmHg (n=821), DBP≥90 and SBP<140mmHg (n=28), normal BP, taking anti-hypertensive drugs (n=1138), normal BP, not taking anti-hypertensive drugs, history of hypertension (n=193), and baseline HF (n=101)...
March 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28290375/angle-dependent-magnetoresistance-and-quantum-oscillations-in-high-mobility-semimetal-luptbi
#8
Guizhou Xu, Zhipeng Hou, Yue Wang, Xiaoming Zhang, Hongwei Zhang, Enke Liu, X Xi, Feng Xu, Guangheng Wu, Xixiang Zhang, Wenhong Wang
The recent discovery of ultrahigh mobility and large positive magnetoresistance in topologically non-trivial Half-Heusler semimetal LuPtBi provides a unique playground for studying exotic physics and significant perspective for device applications. As an fcc-structured electron-hole-compensated semimetal, LuPtBi theoretically exhibits six symmetrically arranged anisotropic electron Fermi pockets and two nearly-spherical hole pockets, offering the opportunity to explore the physics of Fermi surface with a simple angle-related magnetotransport properties...
March 14, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28288038/immunohistochemical-characterization-of-fumarate-hydratase-fh-and-succinate-dehydrogenase-sdh-in-cutaneous-leiomyomas-for-detection-of-familial-cancer-syndromes
#9
Cody S Carter, Stephanie L Skala, Arul M Chinnaiyan, Jonathan B McHugh, Javed Siddiqui, Xuhong Cao, Saravana M Dhanasekaran, Douglas R Fullen, Amir Lagstein, May P Chan, Rohit Mehra
Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) is caused by germline mutations in the FH gene, and is associated with increased incidence of leiomyomas and a potentially aggressive variant of renal cell carcinoma (HLRCC-associated RCC). Absent immunohistochemical expression of fumarate hydratase (FH) has previously been used to diagnose HLRCC-associated RCC, but immunohistochemical staining of leiomyomas is not standard practice. We performed immunohistochemistry (IHC) on whole sections from consecutive cutaneous leiomyomas from our archives to evaluate for both FH and succinate dehydrogenase B expression, in addition to clinicopathologic data collection and review of all hematoxylin and eosin-stained slides for blinded morphologic evaluation of features reported to be seen in HLRCC-associated uterine leiomyomas...
March 10, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28287956/fast-supervised-discrete-hashing
#10
Jie Gui, Tongliang Liu, Zhenan Sun, Dacheng Tao, Tieniu Tan
Learning-based hashing algorithms are "hot topics" because they can greatly increase the scale at which existing methods operate. In this paper, we propose a new learning-based hashing method called "fast supervised discrete hashing" (FSDH) based on "supervised discrete hashing" (SDH). Regressing the training examples (or hash code) to the corresponding class labels is widely used in ordinary least squares regression. Rather than adopting this method, FSDH uses a very simple yet effective regression of the class labels of training examples to the corresponding hash code to accelerate the algorithm...
March 7, 2017: IEEE Transactions on Pattern Analysis and Machine Intelligence
https://www.readbyqxmd.com/read/28284009/pituitary-carcinoma-in-a-patient-with-an-sdhb-mutation
#11
Nicola Tufton, Federico Roncaroli, Irene Hadjidemetriou, Mary N Dang, Judit Dénes, Leonardo Guasti, Maria Thom, Michael Powell, Stephanie E Baldeweg, Naomi Fersht, Márta Korbonits
We present the first case of pituitary carcinoma occurring in a patient with a succinate dehydrogenase subunit B (SDHB) mutation and history of paraganglioma. She was initially treated for a glomus tumour with external beam radiotherapy. Twenty-five years later, she was diagnosed with a non-functioning pituitary adenoma, having developed bitemporal hemianopia. Recurrence of the pituitary lesion (Ki-67 10% and p53 overexpressed) occurred 5 years after her transsphenoidal surgery, for which she underwent two further operations followed by radiotherapy...
March 10, 2017: Endocrine Pathology
https://www.readbyqxmd.com/read/28278469/deep-hashing-for-scalable-image-search
#12
Jiwen Lu, Venice Erin Liong, Jie Zhou
In this paper, we propose a new deep hashing (DH) approach to learn compact binary codes for scalable image search. Unlike most existing binary codes learning methods which usually seek a single linear projection to map each sample into a binary feature vector, we develop a deep neural network to seek multiple hierarchical non-linear transformations to learn these binary codes, so that the nonlinear relationship of samples can be well exploited. Our model is learned under three constraints at the top layer of the developed deep network: 1) the loss between the compact real-valued code and the learned binary vector is minimized, 2) the binary codes distribute evenly on each bit, and 3) different bits are as independent as possible...
March 3, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28274622/-social-determinants-of-health-and-disability-updating-the-model-for-determination
#13
Mauro Tamayo, Álvaro Besoaín, Jame Rebolledo
Social determinants of health (SDH) are conditions in which people live. These conditions impact their lives, health status and social inclusion level. In line with the conceptual and comprehensive progression of disability, it is important to update SDH due to their broad implications in implementing health interventions in society. This proposal supports incorporating disability in the model as a structural determinant, as it would lead to the same social inclusion/exclusion of people described in other structural SDH...
March 5, 2017: Gaceta Sanitaria
https://www.readbyqxmd.com/read/28270683/max-inactivation-is-an-early-event-in-gist-development-that-regulates-p16-and-cell-proliferation
#14
Inga-Marie Schaefer, Yuexiang Wang, Cher-Wei Liang, Nacef Bahri, Anna Quattrone, Leona Doyle, Adrian Mariño-Enríquez, Alexandra Lauria, Meijun Zhu, Maria Debiec-Rychter, Susanne Grunewald, Jaclyn F Hechtman, Armelle Dufresne, Cristina R Antonescu, Carol Beadling, Ewa T Sicinska, Matt van de Rijn, George D Demetri, Marc Ladanyi, Christopher L Corless, Michael C Heinrich, Chandrajit P Raut, Sebastian Bauer, Jonathan A Fletcher
KIT, PDGFRA, NF1 and SDH mutations are alternate initiating events, fostering hyperplasia in gastrointestinal stromal tumours (GISTs), and additional genetic alterations are required for progression to malignancy. The most frequent secondary alteration, demonstrated in ∼70% of GISTs, is chromosome 14q deletion. Here we report hemizygous or homozygous inactivating mutations of the chromosome 14q MAX gene in 16 of 76 GISTs (21%). We find MAX mutations in 17% and 50% of sporadic and NF1-syndromic GISTs, respectively, and we find loss of MAX protein expression in 48% and 90% of sporadic and NF1-syndromic GISTs, respectively, and in three of eight micro-GISTs, which are early GISTs...
March 8, 2017: Nature Communications
https://www.readbyqxmd.com/read/28268147/insular-infarction-in-subdural-hematoma-a-case-series-and-pathophysiologic-review
#15
REVIEW
Daniel C Sacchetti, Sandra C Yan, Bradford B Thompson, Corey R Fehnel
Subdural hematoma (SDH) is among the most common conditions managed by neurologists and neurosurgeons. As SDH incidence rates increase, a wider spectrum of SDH related complications have become evident. We prospectively identified a series of three patients with similar patterns of ipsilateral insular diffusion weighted imaging (DWI) hyperintensity associated with subdural hematoma. Detailed chart review was performed, and cases are described in relation to anatomy and proposed pathophysiology of venous hypertension and arterial vasospasm...
March 3, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28264246/radiologic-findings-and-patient-factors-associated-with-30-day-mortality-after-surgical-evacuation-of-subdural-hematoma-in-patients-less-than-65-years-old
#16
Myung-Hoon Han, Je Il Ryu, Choong Hyun Kim, Jae Min Kim, Jin Hwan Cheong, Hyeong-Joong Yi
OBJECTIVE: The purpose of this study is to evaluate the associations between 30-day mortality and various radiological and clinical factors in patients with traumatic acute subdural hematoma (SDH). During the 11-year study period, young patients who underwent surgery for SDH were followed for 30 days. Patients who died due to other medical comorbidities or other organ problems were not included in the study population. METHODS: From January 1, 2004 to December 31, 2014, 318 consecutive surgically-treated traumatic acute SDH patients were registered for the study...
March 2017: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/28261091/ginsenoside-rg5-inhibits-succinate-associated-lipolysis-in-adipose-tissue-and-prevents-muscle-insulin-resistance
#17
Na Xiao, Le-Le Yang, Yi-Lin Yang, Li-Wei Liu, Jia Li, Baolin Liu, Kang Liu, Lian-Wen Qi, Ping Li
Endoplasmic reticulum (ER) stress, inflammation, and lipolysis occur simultaneously in adipose dysfunction and contribute to insulin resistance. This study was designed to investigate whether ginsenoside Rg5 could ameliorate adipose dysfunction and prevent muscle insulin resistance. Short-term high-fat diet (HFD) feeding induced hypoxia with ER stress in adipose tissue, leading to succinate accumulation due to the reversal of succinate dehydrogenase (SDH) activity. Rg5 treatment reduced cellular energy charge, suppressed ER stress and then prevented succinate accumulation in adipose tissue...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28258932/herbal-medicine-oreongsan-for-recurrent-chronic-subdural-hematoma-a-case-report
#18
Ki-Ho Cho, Seungwon Kwon, Woo-Sang Jung, Sang-Kwan Moon
Recently, the East-Asian herbal complex Oreongsan (Goreisan in Japanese and Wulingsan in Chinese) has been noted for its usefulness in preventing postoperative recurrence of chronic subdural hematoma (CSDH). Here, we present a case of CSDH, an 84-year-old man which had recurred four times, despite three previous burr-hole surgeries. Following the fourth burr-hole surgery, an herbal medicine called Oreongsan (TJ-17, Tsumura, Japan, 15g/d) was administered to the patient in hopes of preventing another CSDH recurrence...
December 18, 2016: Explore: the Journal of Science and Healing
https://www.readbyqxmd.com/read/28255624/genetic-and-epigenetic-patterns-in-patients-with-the-head-and-neck-paragangliomas-associate-with-differential-clinical-characteristics
#19
Hongsai Chen, Weidong Zhu, Xiye Li, Lu Xue, Zhaoyan Wang, Hao Wu
PURPOSE: In addition to genetic alterations, the importance of a CpG island methylator phenotype, characterized by methylation of multiple tumour-suppressor genes (TSGs), has been acknowledged in many cancer types. This study was done to determine the impact of genetic and epigenetic patterns on the clinical characteristics of the head and neck paragangliomas (HNPGLs). METHODS: The retrospective study examined a series of 37 patients with HNPGLs who underwent surgical resection between 2010 and 2015...
March 3, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28255111/-sirtuin-type-1-signaling-pathway-mediates-the-effect-of-diosgenin-on-chondrocyte-metabolisms-in-osteoarthritis
#20
Jun Liu, Xiaole He, Ping Zhen, Hui Chen, Shenghu Zhou, Qi Tian, Rong Wang, Xusheng Li
To observe the effect of sirtuin type 1 (SIRT1) signaling pathway on chondrocyte metabolism and mitochondrial oxidative stress, to explore roles of SIRT1 signaling pathway and diosgenin (Dgn) in pathogenesis of osteoarthritis (OA).
 Methods: To establish C57BL/6 mouse (13.5-18.0 g) model of OA. The chondrocytes were randomly assigned into 4 groups: an OA group, a Dgn+OA group, a Dgn+Sirtinol+OA group, and a Sirtinol+OA group. Expressions of SIRT1, acetylation-regulated transcription factor 1 (Ac-FOXO1), and Bax were detected in the 4 groups by Western blot...
February 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
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