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https://www.readbyqxmd.com/read/29300464/promysalin-elicits-species-selective-inhibition-of-pseudomonas-aeruginosa-by-targeting-succinate-dehydrogenase
#1
Colleen Keohane, Andrew Steele, Christian Fetzer, Jittasak Khowsathit, Daria Van Tyne, Lucile Moynie, Michael S Gilmore, John Karanicolas, Stephan A Sieber, William M Wuest
Natural products have served as an inspiration to scientists both for their complex three-dimensional architecture and exquisite biological activity. Promysalin is one such Pseudomonad secondary metabolite that exhibits narrow-spectrum antibacterial activity, originally isolated from the rhizosphere. We herein utilize affinity-based protein profiling (AfBPP) to identify succinate dehydrogenase (Sdh) as the biological target of the natural product. The target was further validated in silico, in vitro, in vivo, and through the generation, and sequencing, of a resistant mutant...
January 4, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29278991/managing-nonoperable-intracranial-bleeding-associated-with-apixaban-a-series-of-2-cases
#2
Andrew C Faust, Dang M Tran, Catherine Lo, Sophia Lai, Lyndsay Sheperd, Mary Liu, Tina Denetclaw
OBJECTIVE: To report 2 cases of nonoperable intracranial bleeding associated with apixaban managed by 3-factor prothrombin complex concentrate (PCC3). CASE SUMMARIES: Case 1 presented with a 1.3-cm left parieto-occipital hemorrhage and a thin subdural hematoma (SDH) on the left tentorium of the brain about 6 hours after his last dose of apixaban. Case 2 presented with a 4-mm left parafalcine SDH with time of most recent apixaban dose unknown. The patients received 24...
January 1, 2017: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29278547/fenofibrate-attenuates-cardiac-and-renal-alterations-in-young-salt-loaded-spontaneously-hypertensive-stroke-prone-rats-through-mitochondrial-protection
#3
Laura Castiglioni, Alice Pignieri, Melania Fiaschè, Marco Giudici, Maurizio Crestani, Nico Mitro, Mauro Abbate, Carlamaria Zoja, Daniela Rottoli, Claudia Foray, Fabio Fiordaliso, Uliano Guerrini, Elena Tremoli, Luigi Sironi, Paolo Gelosa
OBJECTIVES: The simultaneous presence of cardiac and renal diseases is a pathological condition that leads to increased morbidity and mortality. Several lines of evidence have suggested that lipid dysmetabolism and mitochondrial dysfunction are pathways involved in the pathological processes affecting the heart and kidney. In the salt-loaded spontaneously hypertensive stroke-prone rat (SHRSP), a model of cardiac hypertrophy and nephropathy that shows mitochondrial alterations in the myocardium, we evaluated the cardiorenal effects of fenofibrate, a peroxisome proliferator-activated receptor alpha (PPARα) agonist that acts by modulating mitochondrial and peroxisomal fatty acid oxidation...
December 22, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/29258949/outcome-of-traumatic-brain-injury-in-elderly-population-a-tertiary-centre-experience-from-a-developing-country
#4
G Lakshmi Prasad, N Anmol, Girish R Menon
BACKGROUND: The increasing ratio of elderly population has contributed to increased incidence of TBI in this cohort. Authors put forward their institutional experience in the management of elderly TBI. MATERIALS AND METHODS: A 3-year retrospective analysis of 73 consecutive patients aged ≥ 65 years admitted with TBI at our university hospital was performed. The following were excluded-concussion injuries, chronic subdural hematomas (SDH), patients discharged against medical advice (DAMA) and declared dead soon after arrival (within 6 hours)...
December 16, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29248778/radiological-factors-predicting-deterioration-of-mental-status-in-patients-with-acute-traumatic-subdural-hematoma
#5
Yu Deok Won, Min Kyun Na, Je-Il Ryu, Jin-Hwan Cheong, Jae-Min Kim, Choong-Hyun Kim, Myung-Hoon Han
OBJECTIVE: The purpose of the study was to evaluate whether SDH volume and other radiological factors predict deterioration of mental status in patients with acute traumatic SDH. METHODS: SDH volumes were measured with a semi-automated tool. The area under the receiver operating characteristic (ROC) curve was used to determine optimal cut-off values for mental deterioration, including the following variables: midline shift, SDH volume, hematoma thickness, and Sylvian fissure ratio...
December 14, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29239034/succinate-dehydrogenase-sdh-deficient-neoplasia
#6
REVIEW
Anthony J Gill
The succinate dehydrogenase (SDH) complex is a key respiratory enzyme composed of four subunits: SDHA, SDHB, SDHC and SDHD. Remarkably, immunohistochemistry for SDHB becomes negative whenever there is bi-alleic inactivation of any component of SDH, which is very rare in the absence of syndromic disease. Therefore, loss of SDHB immunohistochemistry serves as a marker of syndromic disease, usually germline mutation of one of the SDH subunits. Tumours which show loss of SDHB expression are termed succinate dehydrogenase-deficient...
January 2018: Histopathology
https://www.readbyqxmd.com/read/29236067/how-well-do-health-mediation-programs-address-the-determinants-of-the-poor-health-status-of-roma-a-longitudinal-case-study
#7
Andrej Belak, Zuzana Dankulincova Veselska, Andrea Madarasova Geckova, Jitse P van Dijk, Sijmen A Reijneveld
In Central and Eastern Europe (CEE), health-mediation programs (HMPs) have become central policy instruments targeting health inequities between segregated Roma and general populations. Social determinants of health (SDH) represent the root causes behind health inequities. We therefore evaluated how an HMP based in Slovakia addressed known SDH in its agenda and its everyday implementation. To produce descriptive data on the HMP's agenda and everyday implementation we observed and consulted 70 program participants across organizational levels and 30 program recipients over the long-term...
December 13, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29227120/-molecular-mechanisms-of-primary-and-secondary-resistance-molecular-genetic-features-and-characteristics-of-kit-pdgfra-non-mutated-gists
#8
Alena Kalfusová, Roman Kodet
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. Most of them arise due to activating mutations in KIT (75 - 85 %) or PDGFRA (less than 10 %) genes. Identification of the activating mutations in KIT and PDGFRA genes, which code for receptor tyrosine kinases (RTKs), has improved the outcome of targeted therapy of metastatic, unresectable or recurrent GISTs. Primary and/or secondary resistance represents a significant problem in the targeted therapy by Imatinib mesylate (IM) in patients with GIST...
2017: Ceskoslovenská Patologie
https://www.readbyqxmd.com/read/29225013/succinate-dehydrogenase-prospect-for-neurodegenerative-diseases
#9
REVIEW
Mohammad Jodeiri Farshbaf, Abbas Kiani-Esfahani
Onset of Alzheimer's, Parkinson's and Huntington's diseases as neurodegenerative disorders is increased by age. Alleviation of clinical symptoms and protection of neurons against degeneration are the main aspects of researches to establish new therapeutic strategies. Many studies have shown that mitochondria play crucial roles in high energy demand tissues like brain. Impairments in mitochondrial activity and physiology can makes neurons vulnerable to stress and degeneration. Succinate dehydrogenase (SDH) connects tricarboxylic cycle to the electron transport chain...
December 7, 2017: Mitochondrion
https://www.readbyqxmd.com/read/29206829/-transition-from-millennium-development-goals-to-sustainable-development-goals-from-the-perspective-of-the-social-determinants-of-health-and-health-equity
#10
Manue Urbina-Fuentes, Luis Jasso-Gutiérrez, Raffaela Schiavon-Ermani, Rafael Lozano, Jacobo Finkelman
The United Nations Declaration of 2000 agreed on eight millennium development goals (MDGs) to be met in 2015. The results show that poverty continues through population growth and advances in both rich and poor countries are threatened by economic crises and inequities in geographic areas and population groups within countries. In a globalized world with great social and economic inequalities, from the perspective of the social determinants of health (SDH), the relevance of the new 17 sustainable development goals (SDGs) is greater...
November 2017: Gaceta Médica de México
https://www.readbyqxmd.com/read/29204422/discovering-novel-alternaria-solani-succinate-dehydrogenase-inhibitors-by-in-silico-modeling-and-virtual-screening-strategies-to-combat-early-blight
#11
Sehrish Iftikhar, Ahmad A Shahid, Sobia A Halim, Pieter J Wolters, Vivianne G A A Vleeshouwers, Ajmal Khan, Ahmed Al-Harrasi, Shahbaz Ahmad
Alternaria blight is an important foliage disease caused by Alternaria solani. The enzyme Succinate dehydrogenase (SDH) is a potential drug target because of its role in tricarboxylic acid cycle. Hence targeting Alternaria solani SDH enzyme could be efficient tool to design novel fungicides against A. solani. We employed computational methodologies to design new SDH inhibitors using homology modeling; pharmacophore modeling and structure based virtual screening. The three dimensional SDH model showed good stereo-chemical and structural properties...
2017: Frontiers in Chemistry
https://www.readbyqxmd.com/read/29203309/spontaneous-acute-arterial-subdural-haematoma
#12
Michael J Mulcahy, Joga Chaganti, Ashraf Dower, Darweesh Al-Khawaja
BACKGROUND: Spontaneous acute arterial subdural haematoma (SDH) is a rare entity caused by haemorrhage from a cortical perisylvian artery without a known precipitant. CASE DESCRIPTION: A 53 year old man presented with a two day history of acute onset headache and dysphasia. He had a generalised seizure on arrival to hospital. There was no history of trauma. A CT demonstrated an acute left sided SDH. A CT angiogram and a digital subtraction angiogram demonstrated active contrast extravasation into the SDH...
December 1, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29201843/clinical-features-and-outcomes-of-bilateral-decompression-surgery-for-immediate-contralateral-hematoma-after-craniectomy-following-acute-subdural-hematoma
#13
Young Hwan Choi, Tea Kyoo Lim, Sang Gu Lee
Objective: Immediate contralateral epidural hematoma (EDH) and traumatic intracerebral hematoma (T-ICH) after craniectomy for traumatic subdural hematoma (SDH) are rare but devastating post-operative complications. Their clinical features and outcomes are not well studied. In this report, we present the clinical features and outcomes of immediate contralateral acute hematoma cases requiring a second operation. Methods: This study includes 10 cases of immediate contralateral EDH and T-ICH following bilateral craniectomy for the evacuation of traumatic SDH and contralateral hematoma between 2004 and 2015...
October 2017: Korean Journal of Neurotrauma
https://www.readbyqxmd.com/read/29192373/flexible-endoscopically-assisted-evacuation-of-acute-and-subacute-subdural-hematoma-through-a-small-craniotomy-preliminary-results
#14
Toshinari Kawasaki, Yoshitaka Kurosaki, Hitoshi Fukuda, Masanori Kinosada, Ryota Ishibashi, Akira Handa, Masaki Chin, Sen Yamagata
BACKGROUND: The first choice to treat acute subdural hematoma (SDH) is a large craniotomy under general anesthesia. However, increasing age or comorbid burden of the patients may render invasive treatment strategy inappropriate. These medically frail patients with SDH may benefit from a combination of small craniotomy and endoscopic hematoma removal, which is less invasive and even available under local anesthesia. Although hematoma evacuation with a rigid endoscope for acute or subacute SDHs has been reported in the literature, use of a flexible endoscope may have distinct advantages...
November 30, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29184717/intraventricular-hemorrhage-possibly-extending-from-an-infratentorial-subdural-hematoma-via-a-perforated-suprapineal-recessus-in-a-full-term-neonate
#15
Yoichiro Serita, Takato Morioka, Nobuya Murakami, Nobuko Kawamura, Yasushi Takahata, Ryutaro Kira
Background: Although intraventricular hemorrhage (IVH) is very rarely reported in full-term neonates, it may occur in children with perinatal trauma, asphyxia, and coagulation disorders, and may originate in the choroid plexus and residual subependymal germinal matrix layer. Case Description: We present the case of a full-term baby with IVH. She had no perinatal problems or coagulation disorders. Sagittal views of neuroimages demonstrated that the IVH possibly extended from a subdural hemorrhage (SDH) in the infratentorial area via a perforated suprapineal recessus...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/29184324/status-of-iodine-nutrition-among-pregnant-women-attending-antenatal-clinic-of-a-secondary-care-hospital-a-cross-sectional-study-from-northern-india
#16
Shashi Kant, Partha Haldar, Ayush Lohiya, Kapil Yadav, Chandrakant S Pandav
Background: Daily requirement of iodine increases during pregnancy making pregnant women a high-risk group for iodine deficiency disorders. The limited available literature shows that even in iodine sufficient population, pregnant women are iodine deficient. Objective: The objective of this study is to assess the current iodine nutrition status among pregnant women in Ballabgarh, district Faridabad, Haryana. Materials and Methods: Pregnant women were recruited from antenatal clinic (ANC) of subdistrict hospital (SDH), Ballabgarh, Haryana...
October 2017: Indian Journal of Community Medicine
https://www.readbyqxmd.com/read/29183578/molluscicidal-activity-and-physiological-toxicity-of-macleaya-cordata-alkaloids-components-on-snail-oncomelania-hupensis
#17
Wenshan Ke, Xiong Lin, Zhengshen Yu, Qiqiang Sun, Qian Zhang
In order to search new local plant molluscicides for the control of the vectors of schistosomiasis, leaves of Macleaya cordata (Willd) R. Br. were used to extract and separate alkaloid components by thinner acid method and column chromatography, and the molluscicidal effect of alkaloid components against snail Oncomelania hupensis was determined by bioassay. The results showed that 7 alkaloid components (AN1-7) were obtained after extracting and separating alkaloids from the leaves of M. cordata, where AN2 was found being the most toxic against snail O...
November 2017: Pesticide Biochemistry and Physiology
https://www.readbyqxmd.com/read/29180251/renal-cell-carcinoma-with-angioleiomyoma-like-stroma-and-clear-cell-papillary-renal-cell-carcinoma-exploring-sdhb-protein-immunohistochemistry-and-the-relationship-to-tuberous-sclerosis-complex
#18
Sean R Williamson, Jason L Hornick, John N Eble, Nilesh S Gupta, Craig G Rogers, Lawrence True, David J Grignon, Liang Cheng
Renal cell carcinoma (RCC) with angioleiomyoma-like stroma appears to be molecularly distinct from clear cell RCC; however, its relationship to clear cell papillary RCC remains debated. Recent studies have found that similar tumors sometimes occur in patients with tuberous sclerosis complex (TSC), of which one study found unexpectedly negative succinate dehydrogenase (SDH) B immunostaining. We evaluated immunohistochemistry for SDHB in 12 apparently sporadic RCCs with angioleiomyoma-like stroma and correlated with clinical information for stigmata of TSC...
November 24, 2017: Human Pathology
https://www.readbyqxmd.com/read/29177457/assessing-the-capacity-of-social-determinants-of-health-data-to-augment-predictive-models-identifying-patients-in-need-of-wraparound-social-services
#19
Suranga N Kasthurirathne, Joshua R Vest, Nir Menachemi, Paul K Halverson, Shaun J Grannis
Introduction: A growing variety of diverse data sources is emerging to better inform health care delivery and health outcomes. We sought to evaluate the capacity for clinical, socioeconomic, and public health data sources to predict the need for various social service referrals among patients at a safety-net hospital. Materials and Methods: We integrated patient clinical data and community-level data representing patients' social determinants of health (SDH) obtained from multiple sources to build random forest decision models to predict the need for any, mental health, dietitian, social work, or other SDH service referrals...
November 21, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29170162/classification-of-gastrointestinal-stromal-tumor-syndromes
#20
Priya Gopie, Lin Mei, Anthony C Faber, Steven R Grossman, Steven C Smith, Sosipatros Boikos
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract, thought to derive from neoplastic outgrowth of the interstitial cells of Cajal. Building on recent advances in recognition, classification, and diagnosis, the past two decades have seen a changing paradigm with molecular diagnostics and targeted therapies. KIT and PDGFRA mutations account for 85-90% GIST carcinogenesis. However, the remaining 10-15% of GISTs which until recently were called KIT/PDGFRA wild type GISTs, have been found to have one of several mutations, including in the SDHA, B, C, D, BRAF and NF1 genes...
November 23, 2017: Endocrine-related Cancer
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