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https://www.readbyqxmd.com/read/27914543/extract-of-syringa-oblata-a-new-biocontrol-agent-against-tobacco-bacterial-wilt-caused-by-ralstonia-solanacearum
#1
Wanming Bai, Fanyu Kong, Yong Lin, Chengsheng Zhang
Ralstonia solanacearum causes serious wilt disease in tobacco. To effectively control this disease, the antibacterial activity of 95% ethanol extracts from the flower buds of Syringa oblata was examined. Based on GC-MS analysis and an inhibition experiment against R. solanacearum, the main antibacterial component is eugenol. We further determined the effect of eugenol on the physiology, biochemistry, and cellular morphology of R. solanacearum. The results showed that eugenol can destroy wilt bacteria, leading to the disappearance of flagella, the leakage of contents, and the appearance of a cavity...
November 2016: Pesticide Biochemistry and Physiology
https://www.readbyqxmd.com/read/27914224/a-systematic-review-of-epileptic-seizures-in-adults-with-subdural-haematomas
#2
REVIEW
Sae-Yeon Won, Juergen Konczalla, Daniel Dubinski, Adriano Cattani, Colleen Cuca, Volker Seifert, Felix Rosenow, Adam Strzelczyk, Thomas M Freiman
BACKGROUND: Posttraumatic epileptic seizures (PTS) are a serious complication in patients with subdural haematoma (SDH). However, to date, several studies have shown discordances about SDH-associated seizures in terms of incidence, risk factors and prophylactic antiepileptic treatment. OBJECTIVE: The aim of this study was to analyse the incidence, risk factors of PTS and the role of prophylactic antiepileptic treatment in patients with SDH. DATA SOURCES: A systematic literature review examining PTS in patients with SDH was performed using PubMed gateway, Cochrane Central Register of Controlled Trials, and Excerpta Medica dataBASE between September 1961 and February 2016...
November 25, 2016: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/27913757/the-impact-of-fiscal-policies-on-the-socioeconomic-determinants-of-health-a-structured-review
#3
Isabel Mosquera, Yolanda González-Rábago, Amaia Bacigalupe, Marc Suhrcke
There has been considerable recent debate around the alleged impact of discretionary fiscal policies - especially austerity policies - on health and health inequalities. Assuming that most of the impact will have to run via the effect of fiscal policies on socioeconomic determinants of health (SDH), it is of interest to gain a further understanding of the relationship between fiscal policies and SDH. Therefore, the aim of this article is to review the recent evidence on the impact of discretionary fiscal policies on key SDH, i...
December 2, 2016: International Journal of Health Services: Planning, Administration, Evaluation
https://www.readbyqxmd.com/read/27910947/renal-cell-carcinoma-with-tfe3-translocation-and-succinate-dehydrogenase-b-mutation
#4
Anna Calió, David J Grignon, Bradley A Stohr, Sean R Williamson, John N Eble, Liang Cheng
Translocation renal cell carcinoma and succinate dehydrogenase (SDH)-deficient renal cell carcinoma are now recognized as specific renal tumor types in the World Health Organization (WHO) classification. Both have limited immunohistochemical positivity for epithelial markers, and the spectrum of morphology continues to widen for both of these entities. We identified four renal cell carcinomas with positive TFE3 immunohistochemical staining and negative SDHB staining. The patients (2F, 2M) ranged in age from 19 to 65 years...
December 2, 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/27909949/organ-specific-effects-of-low-dose-zinc-pre-exposure-on-high-dose-zinc-induced-mitochondrial-dysfunction-in-large-yellow-croaker-pseudosciaena-crocea
#5
Jia-Lang Zheng, Shuang-Shuang Yuan, Bin Shen, Chang-Wen Wu
The study was carried out to evaluate the effects of low-dose zinc (Zn) pre-exposure on survival rate, new Zn accumulation, and mitochondrial bioenergetics in the liver and spleen of large yellow croaker exposed to high-dose Zn. To the end, fish were pre-exposed to 0 and 2 mg L(-1) Zn for 48 h and post-exposed to 0 and 12 mg L(-1) Zn for 48 h. Twelve milligrams Zn per liter exposure alone reduced survival rate, but the effect did not appear in the 2 mg L(-1) Zn pre-exposure groups. Two milligrams per liter Zn pre-exposure also ameliorated 12 mg Zn L(-1) induced new Zn accumulation, reactive oxygen species (ROS) levels, and mitochondrial swelling in the liver...
December 1, 2016: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/27908708/chlorogenic-acid-ameliorates-isoproterenol-induced-myocardial-injury-in-rats-by-stabilizing-mitochondrial-and-lysosomal-enzymes
#6
Palaniyandi Akila, Lourthurani Asaikumar, Lakshmanan Vennila
This study was deliberated to aspire the effects of chlorogenic acid (CGA) against myocardial infarction (MI) induced by Isoproterenol (ISO), in a rat model. In the pathology of MI, enzymes released due to the mitochondrial and lysosomal lipid peroxidation play an integral role. Induction of rats with ISO (85mg/kg BW) for 2 consecutive days resulted in a significant decrease in the activities of heart mitochondrial enzymes isocitrate dehydrogenase (ICDH), α-ketoglutarate dehydrogenase (α-KGDH), succinate dehydrogenase (SDH) and malate dehydrogenase (MDH)...
November 28, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27906110/failed-upregulation-of-tfam-protein-and-mitochondrial-dna-in-oxidatively-deficient-fibers-of-chronic-obstructive-pulmonary-disease-locomotor-muscle
#7
Yana Konokhova, Sally Spendiff, R Thomas Jagoe, Sudhakar Aare, Sophia Kapchinsky, Norah J MacMillan, Paul Rozakis, Martin Picard, Mylène Aubertin-Leheudre, Charlotte H Pion, Jean Bourbeau, Russell T Hepple, Tanja Taivassalo
BACKGROUND: Low mitochondrial content and oxidative capacity are well-established features of locomotor muscle dysfunction, a prevalent and debilitating systemic occurrence in patients with chronic obstructive pulmonary disease (COPD). Although the exact cause is not firmly established, physical inactivity and oxidative stress are among the proposed underlying mechanisms. Here, we assess the impact of COPD pathophysiology on mitochondrial DNA (mtDNA) integrity, biogenesis, and cellular oxidative capacity in locomotor muscle of COPD patients and healthy controls...
February 18, 2016: Skeletal Muscle
https://www.readbyqxmd.com/read/27905048/loss-of-succinate-dehydrogenase-subunit-b-sdhb-as-a-prognostic-factor-in-advanced-ileal-well-differentiated-neuroendocrine-tumors
#8
Massimo Milione, Patrick Maisonneuve, Alessio Pellegrinelli, Sara Pusceddu, Giovanni Centonze, Francesca Dominoni, Cecilia Brambilla, Manila Rubino, Antongiulio Faggiano, Roberto Buzzoni, Laura Concas, Luca Giacomelli, Jorgelina Coppa, Vincenzo Mazzaferro, Filippo de Braud
PURPOSE: Abnormal expression of succinate dehydrogenase, (SDH), in particular of the B subunit (SDHB), is implicated in the pathogenesis of neuroendocrine tumors. This study evaluates the distribution of SDHB in WHO grading G1 and G2 intestinal, well-differentiated neuroendocrine tumors and corresponding lymph node or liver metastases. METHODS: We collected ileal well-differentiated neuroendocrine tumors specimens from consecutive patients with prior primary resection and distant synchronous or metachronous liver metastases...
November 30, 2016: Endocrine
https://www.readbyqxmd.com/read/27895633/detection-of-sdhb-gene-mutations-in-sdhi-resistant-isolates-of-botrytis-cinerea-using-high-resolution-melting-hrm-analysis
#9
Anastasios Samaras, Panagiotis Madesis, George S Karaoglanidis
Botrytis cinerea, is a high risk pathogen for fungicide resistance development. Pathogen' resistance to SDHIs is associated with several mutations in sdh gene. The diversity of mutations and their differential effect on cross-resistance patterns among SDHIs and the fitness of resistant strains necessitate the availability of a tool for their rapid identification. This study was initiated to develop and validate a high-resolution melting (HRM) analysis for the identification of P225H/F/L//T, N230I, and H272L/R/Y mutations...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27885942/enlarged-subarachnoid-spaces-and-intracranial-hemorrhage-in-children-with-accidental-head-trauma
#10
Amanda K Fingarson, Maura E Ryan, Suzanne G McLone, Corey Bregman, Emalee G Flaherty
OBJECTIVE Benign external hydrocephalus (BEH) is an enlargement of the subarachnoid spaces (SASs) that can be seen in young children. It is controversial whether children with BEH are predisposed to developing subdural hemorrhage (SDH) with or without trauma. This issue is clinically relevant as a finding of unexplained SDH raises concerns about child abuse and often prompts child protection and law enforcement investigations. METHODS This retrospective study included children (1-24 months of age) who underwent head CT scanning after an accidental fall of less than 6 feet...
November 25, 2016: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/27884696/design-synthesis-and-antifungal-activity-of-novel-fenfuram-diarylamine-hybrids
#11
Hongyu Wang, Xuheng Gao, Xiaoxiao Zhang, Hong Jin, Ke Tao, Taiping Hou
Ten novel fenfuram-diarylamine hybrids were designed and synthesized. And their antifungal activities against four phytopathogenic fungi have been evaluated in vitro and most of the compounds demonstrated a significant antifungal activities against Rhizoctonia solani and Sclerotinia sclerotiorum. Compound 5e exhibited the most potent antifungal activity against R. solani with an EC50 value of 0.037mg/L, far superior to the commercially available fungicide boscalid (EC50=1.71mg/L) and lead fungicide fenfuram (EC50=6...
November 12, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27882427/improved-mdct-monitoring-of-pelvic-myeloma-bone-disease-through-the-use-of-a-novel-longitudinal-bone-subtraction-post-processing-algorithm
#12
Marius Horger, Wolfgang M Thaiss, Hendrik Ditt, Katja Weisel, Jan Fritz, Konstantin Nikolaou, Shu Liao, Christopher Kloth
PURPOSE: To evaluate the diagnostic performance of a novel CT post-processing software that generates subtraction maps of baseline and follow-up CT examinations in the course of myeloma bone lesions. MATERIALS AND METHODS: This study included 61 consecutive myeloma patients who underwent repeated whole-body reduced-dose MDCT at our institution between November 2013 and June 2015. CT subtraction maps classified a progressive disease (PD) vs. stable disease (SD)/remission...
November 23, 2016: European Radiology
https://www.readbyqxmd.com/read/27875899/amelioration-of-energy-metabolism-by-melatonin-in-skeletal-muscle-of-rats-with-lps-induced-endotoxemia
#13
E Ozkok, H Yorulmaz, G Ates, A Aksu, N Balkis, Ö Şahin, S Tamer
In the literature, few studies have investigated the effects of melatonin on energy metabolism in skeletal muscle in endotoxemia. We investigated the effects of melatonin on tissue structure, energy metabolism in skeletal muscle, and antioxidant level of rats with endotoxemia. We divided rats into 4 groups, control, lipopolysaccharide (LPS) (20 mg/kg, i.p., single dose), melatonin (10 mg/kg, i.p., three times), and melatonin + LPS. Melatonin was injected i.p. 30 min before and after the 2nd and 4th hours of LPS injection...
November 23, 2016: Physiological Research
https://www.readbyqxmd.com/read/27871494/current-surgical-management-of-carotid-body-tumors
#14
Victor J Davila, James M Chang, William M Stone, Richard J Fowl, Thomas C Bower, Michael L Hinni, Samuel R Money
BACKGROUND: Carotid body tumors (CBTs) are rare. Management guidelines may include genetic testing for succinate dehydrogenase (SDH) mutations. We performed an institutional review of the surgical management of CBT. METHODS: A retrospective analysis (1994-2015) of CBT excisions at our institution was performed. Data obtained included demographics, genetic testing (if performed), intraoperative details, postoperative morbidity, and long-term outcomes. Data from the first CBT excision were included in patients with bilateral tumors...
December 2016: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/27860139/design-synthesis-and-biological-evaluation-of-novel-nicotinamide-derivatives-bearing-substituted-pyrazole-moiety-as-potential-sdh-inhibitors
#15
Xian-Hai Lv, Zi-Li Ren, Peng-Liu, Bing-Xin Li, Qing-Shan Li, Ming-Jie Chu, Hai-Qun Cao
BACKGROUND: Succinate dehydrogenase (SDH) plays an important role in the Krebs cycle, which is considered as an attractive target for development of succinate dehydrogenase inhibitors (SDHIs) based on antifungal agents. Thus, in order to discover novel molecules with high antifungal activities, SDH as target a series of novel nicotinamide derivatives bearing substituted pyrazole moiety were designed and synthesized firstly via a one-pot reaction. RESULTS: The biological assay data showed that compound 3l displayed the most potent antifungal activity with EC50 values of 33...
November 17, 2016: Pest Management Science
https://www.readbyqxmd.com/read/27858393/the-clinical-predictors-of-shunt-dependent-hydrocephalus-following-aneurysmal-subarachnoid-hemorrhage
#16
Sio Iong Chang, David Hung-Tsang Yen, Ming Dar Tsai, Cheng-Ta Hsieh
AIM: Shunt-dependent hydrocephalus (SDH) is a relatively common complication following aneurysmal subarachnoid hemorrhage (aSAH). Delay in diagnosis and treatment may worsen neurological outcome. This study was conducted to identify early clinical factors associated with SDH following aSAH. MATERIAL AND METHODS: Patients diagnosed with aSAH at our hospital from January 2010 through July 2014 were included. Patients aged ≤ 18 or ≥ 90 year, with concurrent arteriovenous malformation, treated with both clipping and coiling, or not receiving definitive treatment were excluded...
October 17, 2016: Turkish Neurosurgery
https://www.readbyqxmd.com/read/27856430/glycolysis-and-oxidative-phosphorylation-are-essential-for-purinergic-receptor-mediated-angiogenic-responses-in-vasa-vasorum-endothelial-cells
#17
Martin Lapel, Philip Weston, Derek Strassheim, Vijaya Karoor, Nana Burns, Taras Lyubchenko, Petr Paucek, Kurt R Stenmark, Evgenia V Gerasimovskaya
Angiogenesis is an energy demanding process, however, the role of cellular energy pathways and their regulation by extracellular stimuli, especially extracellular nucleotides, remain largely unexplored. Using metabolic inhibitors of glycolysis (2-deoxyglucose, 2-DG) and oxidative phosphorylation (oligomycin, rotenone, and FCCP) we demonstrate that glycolysis and OXPHOS are both essential for angiogenic responses of vasa vasorum endothelial cell (VVEC). Treatment with P2R agonists, ATP and MeSADP, but not P1 receptor agonist, adenosine, increased glycolytic activity in VVEC (measured by extracellular acidification rate and lactate production)...
November 16, 2016: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/27855610/a-review-on-injury-mechanism-of-intracerebral-hemorrhage-in-vehicle-accidents
#18
Fan Li, Honggeng Li, Zhi Xiao, Ronggui Lu, Zhiteng Zhang, Haiyun Zhu, Lihai Ren
BACKGROUND: Intracerebral hemorrhage is one of the most common injuries in vehicle accidents. The aim of this paper is to survey the injury mechanism of intracerebral hemorrhage in vehicle accidents, including contusion, subarachnoid hemorrhage (SAH), subdural hematoma (SDH) and diffuse axonal injury (DAI). METHODS: A condensed overview is given based on the published studies in biomechanical studies on intracerebral hemorrhage. Animal tests, cadaver tests, accident investigations and numerical simulation are the main method used for the mechanism studies...
November 18, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27853460/pre-sowing-seed-treatment-with-24-epibrassinolide-ameliorates-pesticide-stress-in-brassica-juncea-l-through-the-modulation-of-stress-markers
#19
Anket Sharma, Sharad Thakur, Vinod Kumar, Mukesh K Kanwar, Anup K Kesavan, Ashwani K Thukral, Renu Bhardwaj, Pravej Alam, Parvaiz Ahmad
The present experiment was designed to assess the effects of seed soaking with 24-epibrassinolide (EBR) on the physiology of Brassica juncea L. seedlings grown under imidacloprid (IMI) toxicity. Application of EBR increased the length of seedlings, dry weight, and pigment contents, polyphenols, total phenols, and organic acids under IMI toxicity. The expression of genes coding key enzymes of pigment, phenols, polyphenols, and organic acid biosynthetic pathways was also studied including CHLASE (chlorophyllase), PSY (phytoene synthase), CHS (chalcone synthase) and PAL (phenylalanine ammonialyase), CS (citrate synthase), SUCLG1 (succinyl Co-A ligase,), SDH (succinate dehydrogenase), FH (fumarate hydratase), MS (malate synthase)...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27847779/pure-subdural-hemorrhage-caused-by-internal-carotid-artery-dorsal-wall-aneurysm-rupture
#20
Young Woon Lee, Taek Min Nam, Jong Soo Kim, Seung Chyul Hong, Je Young Yeon
A 37-year-old woman was admitted to our hospital with altered mentality. The patient was diagnosed an internal carotid artery (ICA) dorsal wall aneurysm leading to acute subdural hemorrhage (SDH) without occurring subarachnoid hemorrhage and/or internal parenchymal hemorrhage. An aneurysmal neck clipping and hematoma evacuation were performed at once. A pure SDH by ruptured aneurysm is unusual, but it is important to consider it if a SDH patient has no other medical history.
September 2016: Journal of Cerebrovascular and Endovascular Neurosurgery
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