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https://www.readbyqxmd.com/read/28811531/the-selective-antifungal-activity-of-drosophila-melanogaster-metchnikowin-reflects-the-species-dependent-inhibition-of-succinate-coenzyme-q-reductase
#1
Mohammad-Reza Bolouri Moghaddam, Thomas Gross, Annette Becker, Andreas Vilcinskas, Mohammad Rahnamaeian
Insect-derived antifungal peptides have a significant economic potential, particularly for the engineering of pathogen-resistant crops. However, the nonspecific antifungal activity of such peptides could result in detrimental effects against beneficial fungi, whose interactions with plants promote growth or increase resistance against biotic and abiotic stress. The antifungal peptide metchnikowin (Mtk) from Drosophila melanogaster acts selectively against pathogenic Ascomycota, including Fusarium graminearum, without affecting Basidiomycota such as the beneficial symbiont Piriformospora indica...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28807341/ultrastructural-examination-of-skin-biopsies-may-assist-in-diagnosing-mitochondrial-cytopathy-when-muscle-biopsies-yield-negative-results
#2
John L McAfee, Christine B Warren, Richard A Prayson
Ultrastructural evaluation of skin biopsies has been utilized for diagnosis of mitochondrial disease. This study investigates how frequently skin biopsies reveal mitochondrial abnormalities, correlates skin and muscle biopsy findings, and describes clinical diagnoses rendered following the evaluation. A retrospective review of surgical pathology reports from 1990 to 2015 identified skin biopsies examined by electron microscopy for suspected metabolic disease. A total of 630 biopsies were included from 615 patients...
August 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/28796048/clinicopathologic-study-of-succinate-dehydrogenase-deficient-gastrointestinal-stromal-tumors-a-single-institutional-experience-in-china
#3
Weizhen Liu, Xiangyu Zeng, Xiuli Wu, Jun He, Jinbo Gao, Xiaoming Shuai, Guobin Wang, Peng Zhang, Kaixiong Tao
Gastrointestinal stromal tumors (GISTs) that are not driven by kinase mutations, as are most GISTs, often show loss of function of the succinate dehydrogenase (SDH) complex and are considered SDH-deficient GISTs. SDH-deficient GISTs share many distinct characteristics compared with conventional GISTs. However, data regarding these characteristics, particularly among Asian people, are relatively limited. The objective of this study was to characterize the clinicopathologic characteristics, treatment, and prognosis of these uncommon GISTs...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28795281/selective-a2a-receptor-antagonist-sch-58261-modulates-striatal-oxidative-stress-and-alleviates-toxicity-induced-by-3-nitropropionic-acid-in-male-wistar-rats
#4
Cristiani F Bortolatto, Angélica S Reis, Mikaela P Pinz, Guilherme T Voss, Renata L Oliveira, Ane G Vogt, Silvane Roman, Cristiano R Jesse, Cristiane Luchese, Ethel A Wilhelm
The aim of the present study was to investigate the effects of SCH58261, a selective adenosine A2A receptor antagonist, on striatal toxicity induced by 3-nitropropionic acid (3-NP) in rats. The experimental protocol consisted of 10 administrations (once a day) of SCH58261 (0.01 or 0.05 mg/kg/day, intraperitoneal, i.p.). From 7th to 10th day, 3-NP (20 mg/kg/day, i.p.) was injected 1 h after SCH58261 administration. Twenty-four hours after the last 3-NP injection, the body weight gain, locomotor activity (open-field test), motor coordination (rotarod test), striatal succinate dehydrogenase (SDH) activity and parameters linked to striatal oxidative status were evaluated in rats...
August 9, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28783811/social-determinants-of-health-in-managed-care-payment-formulas
#5
Arlene S Ash, Eric O Mick, Randall P Ellis, Catarina I Kiefe, Jeroan J Allison, Melissa A Clark
Importance: Managed care payment formulas commonly allocate more money for medically complex populations, but ignore most social determinants of health (SDH). Objective: To add SDH variables to a diagnosis-based payment formula that allocates funds to managed care plans and accountable care organizations. Design, Setting, and Participants: Using data from MassHealth, the Massachusetts Medicaid and Children's Health Insurance Program, we estimated regression models predicting Medicaid spending using a diagnosis-based and SDH-expanded model, and compared the accuracy of their cost predictions overall and for vulnerable populations...
August 7, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28775850/temperature-dependence-of-electron-density-and-electron-electron-interactions-in-monolayer-epitaxial-graphene-grown-on-sic
#6
Chieh-Wen Liu, Chiashain Chuang, Yanfei Yang, Randolph E Elmquist, Yi-Ju Ho, Hsin-Yen Lee, Chi-Te Liang
We report carrier density measurements and electron-electron (e-e) interactions in monolayer epitaxial graphene grown on SiC. The temperature (T)-independent carrier density determined from the Shubnikov-de Haas (SdH) oscillations clearly demonstrates that the observed logarithmic temperature dependence of Hall slope in our system must be due to e-e interactions. Since the electron density determined from conventional SdH measurements does not depend on e-e interactions based on Kohn's theorem, SdH experiments appear to be more reliable compared with the classical Hall effect when one studies the T dependence of the carrier density in the low T regime...
June 2017: 2d Materials
https://www.readbyqxmd.com/read/28768491/succinate-dehydrogenase-deficiency-in-a-pdgfra-mutated-gist
#7
Martin G Belinsky, Kathy Q Cai, Yan Zhou, Biao Luo, Jianming Pei, Lori Rink, Margaret von Mehren
BACKGROUND: Most gastrointestinal stromal tumors (GISTs) harbor mutually exclusive gain of function mutations in the receptor tyrosine kinase (RTK) KIT (70-80%) or in the related receptor PDGFRA (~10%). These GISTs generally respond well to therapy with the RTK inhibitor imatinib mesylate (IM), although initial response is genotype-dependent. An alternate mechanism leading to GIST oncogenesis is deficiency in the succinate dehydrogenase (SDH) enzyme complex resulting from genetic or epigenetic inactivation of one of the four SDH subunit genes (SDHA, SDHB, SDHC, SDHD, collectively referred to as SDHX)...
August 2, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28762523/prediction-accuracy-and-variable-selection-for-penalized-cause-specific-hazards-models
#8
Maral Saadati, Jan Beyersmann, Annette Kopp-Schneider, Axel Benner
We consider modeling competing risks data in high dimensions using a penalized cause-specific hazards (CSHs) approach. CSHs have conceptual advantages that are useful for analyzing molecular data. First, working on hazards level can further understanding of the underlying biological mechanisms that drive transition hazards. Second, CSH models can be used to extend the multistate framework for high-dimensional data. The CSH approach is implemented by fitting separate proportional hazards models for each event type (iCS)...
August 1, 2017: Biometrical Journal. Biometrische Zeitschrift
https://www.readbyqxmd.com/read/28758816/the-interactions-of-cephalosporins-on-polyol-pathway-enzymes-from-sheep-kidney
#9
Bülent Şengül, Şükrü Beydemir
CONTEXT: Cephalosporins are derived from the fungus Acremonium. Due to their strong bactericidal ability, these drugs have to a wide usage in medicine. OBJECTIVE: An investigation of the effects on sheep renal aldose reductase (AR) and sorbitol dehydrogenase (SDH) of cefoperazone, cefazolin, cefuroxime, ceftazidime and ceftriaxone as cephalosporin drugs was carried out in the present study. METHODS: AR and SDH were purified from sheep kidney by ion exchange, gel filtration and affinity methods with approximately 219- and 484-fold, respectively...
July 31, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28757406/subdural-hemorrhage-from-cerebral-amyloid-angiopathy-related-intracerebral-hemorrhage-a-risk-factor-for-postoperative-hemorrhage
#10
Lei Xia, Wen Min, Xianghe Lu, Chengde Wang, Zeping Jiang, Yu Zhang, Sheng Ye, Zhipeng Su, Weiming Zheng, Meihao Wang, Jianmin Li, Jinseng Wu, Qichuan Zhuge
OBJECTIVE: Surgical treatment for cerebral amyloid angiopathy (CAA)-related intracerebral hemorrhage (ICH) remains controversial. A subset of CAA-related ICH with associated subdural hemorrhage (SDH), has been reported. This study aimed to evaluate the clinical results and surgical outcomes of this type of ICH with associated SDH. METHODS: Ninety-eight cases of CAA-related ICH who met Boston criteria, were enrolled in the study. They were divided into those with and without SDH...
July 27, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28752484/composite-pheochromocytoma-paraganglioma-ganglioneuroma-a-clinicopathologic-study-of-eight-cases-with-analysis-of-succinate-dehydrogenase
#11
Sounak Gupta, Jun Zhang, Lori A Erickson
Ganglioneuromas represent the most well-differentiated spectrum of neoplasia arising from the sympathetic nervous system, while neuroblastomas represent the most poorly differentiated counterpart, and ganglioneuroblastomas represent intermediate stages of differentiation. Small series of cases have documented the co-occurrence of ganglioneuroma with a pheochromocytoma (Pheo)/paraganglioma (PGL) component. We report the clinicopathologic features of eight such cases, diagnosed between 2003 and 2015 with a mean follow-up of 22 months (1-47), which were evaluated for syndrome associations, SDHB expression, and clinical outcome...
July 27, 2017: Endocrine Pathology
https://www.readbyqxmd.com/read/28747186/understanding-differences-between-summer-vs-school-obesogenic-behaviors-of-children-the-structured-days-hypothesis
#12
Keith Brazendale, Michael W Beets, R Glenn Weaver, Russell R Pate, Gabrielle M Turner-McGrievy, Andrew T Kaczynski, Jessica L Chandler, Amy Bohnert, Paul T von Hippel
BACKGROUND: Although the scientific community has acknowledged modest improvements can be made to weight status and obesogenic behaviors (i.e., physical activity, sedentary/screen time, diet, and sleep) during the school year, studies suggests improvements are erased as elementary-age children are released to summer vacation. Emerging evidence shows children return to school after summer vacation displaying accelerated weight gain compared to the weight gained occurring during the school year...
July 26, 2017: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/28741220/independent-impact-of-plasma-homocysteine-levels-on-neurological-outcome-following-head-injury
#13
Sivashanmugam Dhandapani, Ankur Bajaj, Chandrasekar Gendle, Inderjeet Saini, Irwanjeet Kaur, Isha Chaudhary, Jasandeep, Jaspinder Kaur, Geetanjali Kalyan, Manju Dhandapani, Sunil K Gupta
Homocysteine (tHcy) has been hardly studied among patients with head injury. This study was to evaluate whether there is any independent impact of tHcy levels on neurological outcome following head injury in a multivariate model. Patients admitted within 24 h of injury were included in the study, along with 20 age- and gender-matched controls. Plasma levels of tHcy were measured at admission using direct immunoassay. All the variables were analyzed with respect to tHcy levels and outcome according to Glasgow Outcome Score (GOS) at 3 months...
July 24, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/28739378/succinate-dehydrogenase-sdh-deficiency-carney-triad-and-the-epigenome
#14
REVIEW
Nikolaos Settas, Fabio R Faucz, Constantine A Stratakis
In this report, we review the relationship between succinate dehydrogenase (SDH) deficiency and the epigenome, especially with regards to two clinical conditions. Carney triad (CT) is a very rare disease with synchronous or metachronous occurrence of at least three different tumor entities; gastric gastrointestinal stromal tumor (GIST), paraganglioma (PGL), and pulmonary chondroma. This condition affects mostly females and it is never inherited. Another disease that shares two of the tumor components of CT, namely GIST and PGL is the Carney-Stratakis syndrome (CSS) or dyad...
July 21, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28738844/analysis-of-sdhaf3-in-familial-and-sporadic-pheochromocytoma-and-paraganglioma
#15
Trisha Dwight, Un Na, Edward Kim, Ying Zhu, Anne Louise Richardson, Bruce G Robinson, Katherine M Tucker, Anthony J Gill, Diana E Benn, Roderick J Clifton-Bligh, Dennis R Winge
BACKGROUND: Germline mutations in genes encoding subunits of succinate dehydrogenase (SDH) are associated with the development of pheochromocytoma (PC) and/or paraganglioma (PGL). As assembly factors have been identified as playing a role in maturation of individual SDH subunits and assembly of the functioning SDH complex, we hypothesized that SDHAF3 variants may be associated with PC/PGL and functionality of SDH. METHODS: DNA was extracted from the blood of 37 individuals (from 23 families) with germline SDH mutations and 18 PC/PGL (15 sporadic, 3 familial) and screened for mutations using a custom gene panel, containing SDHAF3 (SDH assembly factor 3) as well as eight known PC/PGL susceptibility genes...
July 24, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28736404/factors-that-facilitate-addressing-social-determinants-of-health-throughout-community-based-participatory-research-processes
#16
Rebecca Paradiso de Sayu, Shannon M Sparks
BACKGROUND: Community-based participatory research (CBPR) is one approach to addressing health disparities. Considering social conditions that foster disparate health outcomes is a strength of CBPR studies that move beyond a more narrow focus on modifying individual health behaviors. OBJECTIVE: This article examines factors that facilitate addressing the social determinants of health (SDH) throughout a CBPR process. METHODS: Conducting an extensive literature review of relevant key terms and, subsequently, using purposeful snowball sampling, we identified ten CBPR partnerships that addressed SDH and conducted semistructured interviews followed by qualitative content analysis...
2017: Progress in Community Health Partnerships: Research, Education, and Action
https://www.readbyqxmd.com/read/28736353/sport-related-structural-brain-injury-three-cases-of-subdural-hemorrhage-in-american-high-school-football
#17
Aaron M Yengo-Kahn, Ryan M Gardner, Andrew W Kuhn, Gary S Solomon, Christopher M Bonfield, Scott L Zuckerman
BACKGROUND: The risk of sport-related concussion (SRC) has emerged as a major public health concern. In rare instances, sport-related head injuries can be even more severe, such as subdural hemorrhage, epidural hemorrhage, or malignant cerebral edema. Unlike SRCs, sport-related structural brain injury (SRSBI) is rare, may require neurosurgical intervention, and can lead to permanent neurologic deficit or death. Data characterizing SRSBI is limited and many have recognized the need to better understand these catastrophic brain injuries...
July 20, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28724664/biochemical-molecular-and-clinical-characterization-of-succinate-dehydrogenase-subunit-a-variants-of-unknown-significance
#18
Amber E Bannon, Jason D Kent, Isaac Forquer, Ajia Town, Lillian R Klug, Kelly E McCann, Carol Beadling, Olivier Harismendy, Jason K Sicklick, Christopher L Corless, Ujwal Shinde, Michael C Heinrich
Patients who inherit a pathogenic loss-of-function genetic variant involving one of the four succinate dehydrogenase (SDH) subunit genes have up to an 86% chance of developing one or more cancers by the age of 50. If tumors are identified and removed early in these high-risk patients, they have a higher potential for cure.  Unfortunately, many alterations identified in these genes are variants of unknown significance (VUS), confounding the identification of high-risk patients. If we could identify misclassified SDH VUS as benign or pathogenic SDH mutations, we could better select patients for cancer screening procedures and remove tumors at earlier stages...
July 19, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28720665/targeted-exome-sequencing-of-krebs-cycle-genes-reveals-candidate-cancer-predisposing-mutations-in-pheochromocytomas-and-paragangliomas
#19
Laura Remacha, Iñaki Comino-Méndez, Susan Richter, Laura Contreras, Maria Currás-Freixes, Guillermo Pita, Rocío Letón, Antonio Galarreta, Rafael Torres-Pérez, Emiliano Honrado, Scherezade Jiménez, Lorena Maestre, Sebastian Moran, Manel Esteller, Jorgina Satrústegui, Graeme Eisenhofer, Mercedes Robledo, Alberto Cascon
Purpose: Mutations in Krebs cycle genes are frequently found in patients with pheochromocytomas/paragangliomas. Disruption of SDH, FH or MDH2 enzymatic activities lead to accumulation of specific metabolites, which give rise to epigenetic changes in the genome that cause a characteristic hypermethylated phenotype. Tumors showing this phenotype, but no alterations in the known predisposing genes, could harbor mutations in other Krebs cycle genes. <p>Experimental Design: We used downregulation and methylation of RBP1, as a marker of a hypermethylation phenotype, to select eleven pheochromocytomas and paragangliomas for targeted exome sequencing of a panel of Krebs cycle-related genes...
July 18, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28720625/developing-electronic-health-record-ehr-strategies-related-to-health-center-patients-social-determinants-of-health
#20
Rachel Gold, Erika Cottrell, Arwen Bunce, Mary Middendorf, Celine Hollombe, Stuart Cowburn, Peter Mahr, Gerardo Melgar
BACKGROUND: "Social determinants of heath" (SDHs) are nonclinical factors that profoundly affect health. Helping community health centers (CHCs) document patients' SDH data in electronic health records (EHRs) could yield substantial health benefits, but little has been reported about CHCs' development of EHR-based tools for SDH data collection and presentation. METHODS: We worked with 27 diverse CHC stakeholders to develop strategies for optimizing SDH data collection and presentation in their EHR, and approaches for integrating SDH data collection and the use of those data (eg, through referrals to community resources) into CHC workflows...
July 2017: Journal of the American Board of Family Medicine: JABFM
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