Zhijie Wang, Runhong Lei, Zizhu Zhang, Ziteng Chen, Jiaxin Zhang, Meiru Mao, Jiacheng Li, Hongyu Tang, Mengyao Li, Xianwei Luo, Jingru Yang, Ruyu Yan, Qiuyang Liu, Linwen Lv, Kui Chen, Ya-Nan Chang, Hui Yuan, Tong Liu, Jianfei Tong, Linbo Zhu, Tianjiao Liang, Weihua Zhang, Juan Li, Gengmei Xing
Accurate prediction of the relative biological effectiveness (RBE) of boron neutron capture therapy (BNCT) is challenging. The therapy is different from other radiotherapy; the dynamic distribution of boron-containing compounds in tumor cells affects the therapeutic outcome considerably and hampers accurate measurement of the neutron-absorbed dose. Herein, we used boron-containing metal-organic framework nanoparticles (BMOFs) with high boron content to target U87-MG cells and maintain the concentration of the 10 B isotope in cells...
January 24, 2024: ACS Applied Materials & Interfaces