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Boron neutron capture therapy

Bikramjeet Singh, Gurpreet Kaur, Paviter Singh, Kulwinder Singh, Baban Kumar, Ankush Vij, Manjeet Kumar, Rajni Bala, Ramovatar Meena, Ajay Singh, Anup Thakur, Akshay Kumar
Highly water dispersible boron based compounds are innovative and advanced materials which can be used in Boron Neutron Capture Therapy for cancer treatment (BNCT). Present study deals with the synthesis of highly water dispersible nanostructured Boron Nitride (BN). Unique and relatively low temperature synthesis route is the soul of present study. The morphological examinations (Scanning/transmission electron microscopy) of synthesized nanostructures showed that they are in transient phase from two dimensional hexagonal sheets to nanotubes...
October 19, 2016: Scientific Reports
Kayako Isohashi, Eku Shimosegawa, Sadahiro Naka, Yasukazu Kanai, Genki Horitsugi, Ikuko Mochida, Keiko Matsunaga, Tadashi Watabe, Hiroki Kato, Mitsuaki Tatsumi, Jun Hatazawa
BACKGROUND: In boron neutron capture therapy (BNCT), positron emission tomography (PET) with 4-borono-2-(18)F-fluoro-phenylalanine (FBPA) is the only method to estimate an accumulation of (10)B to target tumor and surrounding normal tissue after administering (10)B carrier of L-paraboronophenylalanine and to search the indication of BNCT for individual patient. Absolute concentration of (10)B in tumor has been estimated by multiplying (10)B concentration in blood during BNCT by tumor to blood radioactivity (T/B) ratio derived from FBPA PET...
December 2016: EJNMMI Research
H Koivunoro, L Kankaanranta, H T Joensuu
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Mona Zolfaghari, Mahmood Sedaghatizadeh
An electron linear accelerator (Linac) can be used for boron neutron capture therapy (BNCT) by producing thermal neutron flux. In this study, we used a Varian 2300 C/D Linac and MCNPX.2.6.0 code to simulate an electron-photoneutron source for use in BNCT. In order to decelerate the produced fast neutrons from the photoneutron source, which optimize the thermal neutron flux, a beam-shaping assembly (BSA) was simulated. After simulations, a thermal neutron flux with sharp peak at the beam exit was obtained in the order of 3...
August 31, 2016: Applied Radiation and Isotopes
Flonja Liko, François Hindré, Eduardo Fernandez-Megia
Radiotherapy is one of the most commonly used cancer treatments, with an estimate of 40% success that could be improved further if more efficient targeting and retention of radiation at the tumor site were achieved. This review focuses on the use of dendrimers in radionanotherapy, an emerging technology aimed to improve the efficiency of radiotherapy by implementing nanovectorization, an already established praxis in drug delivery and diagnosis. The labeling of dendrimers with radionuclides also aims to reduce the dose of radiolabeled materials and, hence, their toxicity and tumor resistance...
October 10, 2016: Biomacromolecules
Eku Shimosegawa, Kayako Isohashi, Sadahiro Naka, Genki Horitsugi, Jun Hatazawa
OBJECTIVES: In boron neutron capture therapy (BNCT) for cancer, the accurate estimation of (10)B tissue concentrations, especially in neighboring normal organs, is important to avoid adverse effects. The (10)B concentration in normal organs after loading with (10)B, however, has not been established in humans. In this study, we performed 4-borono-2-[(18)F]-fluoro-phenylalanine ((18)FBPA) PET in healthy volunteers and estimated the chronological changes in the (10)B concentrations of normal organs...
September 1, 2016: Annals of Nuclear Medicine
Ali Taheri, Ali Pazirandeh
To have access to an appropriate neutron source is one of the most demanding requirements for neutron studies. This is important specially in laboratory and clinical applications, which need more compact and accessible sources. The most known neutron sources are fission reactors and natural isotopes, but there is an increasing interest for using accelerator based neutron sources because of their advantages. In this paper, we shall present a photo-neutron source prototype which is designed and fabricated to be used for different neutron researches including in-laboratory neutron activation analysis and neutron imaging, and also preliminary studies in boron neutron capture therapy (BNCT)...
August 29, 2016: Australasian Physical & Engineering Sciences in Medicine
Verónica A Trivillin, Leandro J Bruno, David A Gatti, Mariela Stur, Marcela A Garabalino, Andrea Monti Hughes, Jorge Castillo, Emiliano C C Pozzi, Luis Wentzeis, Hugo Scolari, Amanda E Schwint, Sara Feldman
Rheumatoid arthritis is a chronic autoimmune pathology characterized by the proliferation and inflammation of the synovium. Boron neutron capture synovectomy (BNCS), a binary treatment modality that combines the preferential incorporation of boron carriers to target tissue and neutron irradiation, was proposed to treat the pathological synovium in arthritis. In a previous biodistribution study, we showed the incorporation of therapeutically useful boron concentrations to the pathological synovium in a model of antigen-induced arthritis (AIA) in rabbits, employing two boron compounds approved for their use in humans, i...
August 27, 2016: Radiation and Environmental Biophysics
Hejian Xiong, Xing Wei, Dongfang Zhou, Yanxin Qi, Zhigang Xie, Xuesi Chen, Xiabin Jing, Yubin Huang
Carboranes with rich boron content have showed significant applications in the field of boron neutron capture therapy. Biodegradable derivatives of carborane-conjugated polymers with well-defined structure and tunable loading of boron atoms are far less explored. Herein, a new family of amphiphilic carborane-conjugated polycarbonates was synthesized by ring-opening polymerization of a carborane-installed cyclic carbonate monomer. Catalyzed by TBD from a poly(ethylene glycol) macroinitiator, the polymerization proceeded to relatively high conversions (>65%), with low polydispersity in a certain range of molecular weight...
September 21, 2016: Bioconjugate Chemistry
Weijiang Zhang, Tianyu Liu, Jiao Xu
Boric acid is often added into coolant as neutron capture agent for pressurized water reactor, whose amount is influenced by its abundance and purity. Therefore, the preparation of enriched (10)B boric acid with high purity is beneficial to nuclear industry. (10)B is also used in developing tumor-specific boronated drugs in boron neutron capture therapy. The boronated drug can be administered to patient intravenously, intratumorally, or deposited at tumor site in surgical excision. Thus, enriched (10)B boric acid is of practical significance in the field of medicine...
2016: SpringerPlus
Masayori Ishikawa, Tetsuya Yamamoto, Akira Matsumura, Junichi Hiratsuka, Shin-Ichi Miyatake, Itsuro Kato, Yoshinori Sakurai, Hiroaki Kumada, Shubhechha J Shrestha, Koji Ono
BACKGROUND: Real-time measurement of thermal neutrons in the tumor region is essential for proper evaluation of the absorbed dose in boron neutron capture therapy (BNCT) treatment. The gold wire activation method has been routinely used to measure the neutron flux distribution in BNCT irradiation, but a real-time measurement using gold wire is not possible. To overcome this issue, the scintillator with optical fiber (SOF) detector has been developed. The purpose of this study is to demonstrate the feasibility of the SOF detector as a real-time thermal neutron monitor in clinical BNCT treatment and also to report issues in the use of SOF detectors in clinical practice and their solutions...
2016: Radiation Oncology
Zhenyu Gao, Yukichi Horiguchi, Kei Nakai, Akira Matsumura, Minoru Suzuki, Koji Ono, Yukio Nagasaki
A boron delivery system with high therapeutic efficiency and low adverse effects is crucial for a successful boron neutron capture therapy (BNCT). In this study, we developed boron cluster-containing redox nanoparticles (BNPs) via polyion complex (PIC) formation, using a newly synthesized poly(ethylene glycol)-polyanion (PEG-polyanion, possessing a (10)B-enriched boron cluster as a side chain of one of its segments) and PEG-polycation (possessing a reactive oxygen species (ROS) scavenger as a side chain of one of its segments)...
October 2016: Biomaterials
Elham Bavarnegin, Alireza Sadremomtaz, Hossein Khalafi, Yaser Kasesaz
AIM: Determination of in-phantom quality factors of Tehran research reactor (TRR) boron neutron capture therapy (BNCT) beam. MATERIALS AND METHODS: The doses from thermal neutron reactions with 14N and 10B are calculated by kinetic energy released per unit mass approach, after measuring thermal neutron flux using neutron activation technique. Gamma dose is measured using TLD-700 dosimeter. RESULTS: Different dose components have been measured in a head phantom which has been designed and constructed for BNCT purpose in TRR...
April 2016: Journal of Cancer Research and Therapeutics
Hamid Reza Mirzaei, Amirhossein Sahebkar, Rasoul Salehi, Javid Sadri Nahand, Ehsan Karimi, Mahmoud Reza Jaafari, Hamed Mirzaei
Boron neutron capture therapy (BNCT) occurs when a stable isotope, boton-10, is irradiated with low-energy thermal neutrons to yield stripped down helium-4 nuclei and lithium-7 nuclei. It is a binary therapy in the treatment of cancer in which a cytotoxic event is triggered when an atom placed in a cancer cell. Here, we provide an overview on the application of BNCT in cancer therapy as well as current preclinical and clinical evidence on the efficacy of BNCT in the treatment of melanoma, brain tumors, head and neck cancer, and thyroid cancer...
April 2016: Journal of Cancer Research and Therapeutics
Kenichi Tanaka, Yoshinori Sakurai, Tsuyoshi Kajimoto, Hiroki Tanaka, Takushi Takata, Satoru Endo
The converter configuration for a multi-imaging plate system was investigated for the application of quality assurance in the irradiation field profile for boron neutron capture therapy. This was performed by the simulation calculation using the PHITS code in the fields at the Heavy Water Neutron Irradiation Facility of Kyoto University Reactor. The converter constituents investigated were carbon for gamma rays, and polyethylene with and without LiF at varied (6)Li concentration for thermal, epithermal, and fast neutrons...
September 2016: Applied Radiation and Isotopes
Shunsuke Kikuchi, Daisuke Kanoh, Shinichi Sato, Yoshinori Sakurai, Minoru Suzuki, Hiroyuki Nakamura
Maleimide-conjugating closo-dodecaborate sodium form 5c (MID) synthesized by the nucleophilic ring-opening reaction of closo-dodecaborate-1,4-dioxane complex 2 with tetrabutylammonium (TBA) azide was found to conjugate to free SH of cysteine and lysine residues in BSA under physiological conditions, forming highly boronated BSA that showed high and selective accumulation in tumor and significant tumor growth inhibition in colon 26 tumor-bearing mice subjected to thermal neutron irradiation.
September 10, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
Yukio Morimoto, Hideko Nagasawa, Yoshihiro Uto, Toshiyuki Chatake, Hitoshi Hori
Boron neutron capture therapy (BNCT) is one of the numbers of radiotherapies for treatment of certain cancers. The ability of low-dose irradiation with neutrons or radioactive beams to provide an acceptable quality of life is an objective which has not yet been achieved; therefore it will be necessary to increase the efficiency of the neutron capture reaction by lower dose irradiation and by achieving higher drug concentrations in living cells. Drug selectivity in targeting the affected cellular compartment is most important...
August 2016: Journal of Pharmaceutical Sciences
Micah John Luderer, Barbara Muz, Pilar de la Puente, Sanmathi Chavalmane, Vaishali Kapoor, Raymundo Marcelo, Pratim Biswas, Dinesh Thotala, Buck Rogers, Abdel Kareem Azab
PURPOSE: Boron neutron capture therapy (BNCT) has the potential to become a viable cancer treatment modality, but its clinical translation has been limited by the poor tumor selectivity of agents. To address this unmet need, a boronated 2-nitroimidazole derivative (B-381) was synthesized and evaluated for its capability of targeting hypoxic glioma cells. METHODS: B-381 has been synthesized from a 1-step reaction. Using D54 and U87 glioma cell lines, the in vitro cytotoxicity and cellular accumulation of B-381 has been evaluated under normoxic and hypoxic conditions compared to L-boronophenylalanine (BPA)...
October 2016: Pharmaceutical Research
Kazuma Kobayashi, Hiroaki Kurihara, Yoshiaki Watanabe, Naoya Murakami, Koji Inaba, Satoshi Nakamura, Akihisa Wakita, Hiroyuki Okamoto, Rei Umezawa, Kana Takahashi, Hiroshi Igaki, Yoshinori Ito, Seiichi Yoshimoto, Naoyuki Shigematsu, Jun Itami
BACKGROUND AND PURPOSE: Borono-2-(18)F-fluoro-phenylalanine ((18)F-BPA) has been used to estimate the therapeutic effects of boron neutron capture therapy (BNCT), while (18)F-fluorodeoxyglucose ((18)F-FDG) is the most commonly used positron emission tomography (PET) radiopharmaceutical in a routine clinical use. The aim of the present study was to evaluate spatial correlation between (18)F-BPA and (18)F-FDG uptakes using a deformable image registration-based technique. MATERIAL AND METHODS: Ten patients with head and neck cancer were recruited from January 2014 to December 2014...
September 2016: Applied Radiation and Isotopes
Shin-Ichi Miyatake, Shinji Kawabata, Ryo Hiramatsu, Toshihiko Kuroiwa, Minoru Suzuki, Natsuko Kondo, Koji Ono
Boron neutron capture therapy (BNCT) is a biochemically targeted radiotherapy based on the nuclear capture and fission reactions that occur when non-radioactive boron-10, which is a constituent of natural elemental boron, is irradiated with low energy thermal neutrons to yield high linear energy transfer alpha particles and recoiling lithium-7 nuclei. Therefore, BNCT enables the application of a high dose of particle radiation selectively to tumor cells in which boron-10 compound has been accumulated. We applied BNCT using nuclear reactors for 167 cases of malignant brain tumors, including recurrent malignant gliomas, newly diagnosed malignant gliomas, and recurrent high-grade meningiomas from January 2002 to May 2014...
July 15, 2016: Neurologia Medico-chirurgica
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