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Boron neutron capture therapy

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https://www.readbyqxmd.com/read/29346670/scoping-analysis-of-material-activation-at-a-boron-neutron-capture-therapy-facility-based-on-the-be-p-xn-reaction-with-30-mev-protons
#1
Bo-Lun Lai, Rong-Jiun Sheu
Material activation assessment of a proposed accelerator-based boron neutron capture therapy facility was performed using the FLUKA Monte Carlo code to quantify the magnitude of the problem in terms of the isotope inventories, induced activities, and residual dose rates. Two simplified operation scenarios were considered: a 30-min proton bombardment to simulate a typical session of patient treatment and a long-term 1 year continuous operation to estimate the accumulation of long-lived radionuclides. Following the generation and transport of decay radiation, the space- and time-dependent inventories of induced radionuclides in materials and residual dose rates after shutdown were obtained...
January 16, 2018: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29343841/microdosimetric-modeling-of-biological-effectiveness-for-boron-neutron-capture-therapy-considering-intra-and-intercellular-heterogeneity-in-10b-distribution
#2
Tatsuhiko Sato, Shin-Ichiro Masunaga, Hiroaki Kumada, Nobuyuki Hamada
We here propose a new model for estimating the biological effectiveness for boron neutron capture therapy (BNCT) considering intra- and intercellular heterogeneity in 10B distribution. The new model was developed from our previously established stochastic microdosimetric kinetic model that determines the surviving fraction of cells irradiated with any radiations. In the model, the probability density of the absorbed doses in microscopic scales is the fundamental physical index for characterizing the radiation fields...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29325590/dynamic-changes-in-18f-borono-l-phenylalanine-uptake-in-unresectable-advanced-or-recurrent-squamous-cell-carcinoma-of-the-head-and-neck-and-malignant-melanoma-during-boron-neutron-capture-therapy-patient-selection
#3
Takahiro Morita, Hiroaki Kurihara, Kenta Hiroi, Natsuki Honda, Hiroshi Igaki, Jun Hatazawa, Yasuaki Arai, Jun Itami
BACKGROUND: We evaluated dynamic changes in 18F-borono-L-phenylalanine (18F-BPA) uptake in unresectable, advanced, or recurrent squamous cell carcinoma of the head and neck (SCC) and malignant melanoma (MM) during boron neutron capture therapy (BNCT) patient selection. METHODS: Dynamic changes in the maximum standardized uptake value (SUVmax), tumor-to-normal tissue ratio (TNR), and tumor-to-blood pool ratio (TBR) for 18F-BPA were evaluated in 20 patients with SCC and 8 patients with MM...
January 11, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29315429/impact-of-oxygen-status-on-10b-bpa-uptake-into-human-glioblastoma-cells-referring-to-significance-in-boron-neutron-capture-therapy
#4
Yuki Wada, Katsumi Hirose, Takaomi Harada, Mariko Sato, Tsubasa Watanabe, Akira Anbai, Manabu Hashimoto, Yoshihiro Takai
Boron neutron capture therapy (BNCT) can potentially deliver high linear energy transfer particles to tumor cells without causing severe damage to surrounding normal tissue, and may thus be beneficial for cases with characteristics of infiltrative growth, which need a wider irradiation field, such as glioblastoma multiforme. Hypoxia is an important factor contributing to resistance to anticancer therapies such as radiotherapy and chemotherapy. In this study, we investigated the impact of oxygen status on 10B uptake in glioblastoma cells in vitro in order to evaluate the potential impact of local hypoxia on BNCT...
January 5, 2018: Journal of Radiation Research
https://www.readbyqxmd.com/read/29281044/radiobiological-response-of-u251mg-cho-k1-and-v79-cell-lines-to-accelerator-based-boron-neutron-capture-therapy
#5
Eisuke Sato, Alexander Zaboronok, Tetsuya Yamamoto, Kei Nakai, Sergey Taskaev, Olga Volkova, Ludmila Mechetina, Alexander Taranin, Vladimir Kanygin, Tomonori Isobe, Bryan J Mathis, Akira Matsumura
In the current article, we provide in vitro efficacy evaluation of a unique accelerator-based neutron source, constructed at the Budker Institute of Nuclear Physics (Novosibirsk, Russian Federation), for boron neutron capture therapy (BNCT), which is particularly effective in the case of invasive cancers. U251MG, CHO-K1 and V79 cells were incubated and irradiated in various concentrations of boric acid with epithermal neutrons for 2-3 h in a plexiglass phantom, using 2.0 MeV proton energy and 1.5-3.0 mA proton current, resulting in a neutron fluence of 2...
December 21, 2017: Journal of Radiation Research
https://www.readbyqxmd.com/read/29225308/evaluation-of-radioactivity-in-the-bodies-of-mice-induced-by-neutron-exposure-from-an-epi-thermal-neutron-source-of-an-accelerator-based-boron-neutron-capture-therapy-system
#6
Satoshi Nakamura, Shoji Imamichi, Kazuyoshi Masumoto, Masashi Ito, Akihisa Wakita, Hiroyuki Okamoto, Shie Nishioka, Kotaro Iijima, Kazuma Kobayashi, Yoshihisa Abe, Hiroshi Igaki, Kazuyoshi Kurita, Teiji Nishio, Mitsuko Masutani, Jun Itami
This study aimed to evaluate the residual radioactivity in mice induced by neutron irradiation with an accelerator-based boron neutron capture therapy (BNCT) system using a solid Li target. The radionuclides and their activities were evaluated using a high-purity germanium (HP-Ge) detector. The saturated radioactivity of the irradiated mouse was estimated to assess the radiation protection needs for using the accelerator-based BNCT system. 24Na, 38Cl, 80mBr, 82Br, 56Mn, and 42K were identified, and their saturated radioactivities were (1...
2017: Proceedings of the Japan Academy. Series B, Physical and Biological Sciences
https://www.readbyqxmd.com/read/29183761/calculation-by-gamos-geant4-simulation-of-cellular-energy-distributions-from-alpha-and-lithium-7-particles-created-by-bnct
#7
Ayse Karaoglu, Pedro Arce, Diego Obradors, Juan I Lagares, Perihan Unak
Monte Carlo (MC) has demonstrated to be a suitable technique to evaluate the microdosimetric parameters at the cellular level for Boron Neutron Capture Therapy (BNCT). The objectives of the current study are first to validate GAMOS MC codes with different Geant4 physics models for the range calculations of alpha particles. Once the proper physics is selected, the second objective is to determine the distributions of deposited energy in cellular medium originated by alpha and lithium-7 particles induced by 10B(n,α)7Li...
November 20, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/29182594/pharmacokinetics-of-chlorin-e%C3%A2-cobalt-bis-dicarbollide-conjugate-in-balb-c-mice-with-engrafted-carcinoma
#8
Arthur B Volovetsky, Vladimir S Sukhov, Irina V Balalaeva, Varvara V Dudenkova, Natalia Yu Shilyagina, Аlexey V Feofanov, Anastasija V Efremenko, Mikhail A Grin, Andrey F Mironov, Igor B Sivaev, Vladimir I Bregadze, Anna V Maslennikova
The necessary precondition for efficient boron neutron capture therapy (BNCT) is control over the content of isotope 10B in the tumor and normal tissues. In the case of boron-containing porphyrins, the fluorescent part of molecule can be used for quantitative assessment of the boron content. Study Objective: We performed a study of the biodistribution of the chlorin e₆-Cobalt bis(dicarbollide) conjugate in carcinoma-bearing Balb/c mice using ex vivo fluorescence imaging, and developed a mathematical model describing boron accumulation and release based on the obtained experimental data...
November 28, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29159536/physics-of-epi-thermal-boron-neutron-capture-therapy-epi-thermal-bnct
#9
REVIEW
Ryoichi Seki, Yushi Wakisaka, Nami Morimoto, Masaaki Takashina, Masahiko Koizumi, Hiroshi Toki, Mitsuhiro Fukuda
The physics of epi-thermal neutrons in the human body is discussed in the effort to clarify the nature of the unique radiologic properties of boron neutron capture therapy (BNCT). This discussion leads to the computational method of Monte Carlo simulation in BNCT. The method is discussed through two examples based on model phantoms. The physics is kept at an introductory level in the discussion in this tutorial review.
November 20, 2017: Radiological Physics and Technology
https://www.readbyqxmd.com/read/29148596/transition-metal-catalyzed-selective-cage-b-h-functionalization-of-o-carboranes
#10
Zuowei Xie, Yangjian Quan, Zaozao Qiu
Carboranes are a class of carbon-boron molecular clusters with unusual thermal and chemical stabilities. They have been proved as very useful building blocks in supramolecular design, optoelectronics, nanomaterials, boron neutron capture therapy agents and organometallic/coordination chemistry. Thus, the functionalization of o-carboranes has received growing interests. Over the past decades, most of the works in this area have been focused on cage carbon functionalization as the weakly acidic cage C-H proton can be readily deprotonated by strong bases...
November 17, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29100156/samarium-doped-boron-nitride-nanotubes
#11
Wellington Marcos da Silva, Tiago Hilário Ferreira, Carlos Antônio de Morais, Alexandre Soares Leal, Edésia Martins Barros Sousa
Boron nitride nanotubes doped in situ with samarium (Sm-doped BNNTs) were synthesized at 1150°C under atmosphere of NH3/N2 gas mixture by thermal chemical vapor deposition (TCVD) using samarium oxide that is a product of the process separation of thorium and uranium tailings. The samarium in the BNNTs sample was activated by neutron capture, in a nuclear reactor, producing (152)Sm radioisotopes. The STEM-EELS spectrum and neutron activation show energies attributed to the samarium confirming the in situ doping process during BNNTs growth...
October 31, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/29061819/effect-of-tumor-microenvironment-on-selective-uptake-of-boric-acid-in-hepg2-human-hepatoma-cells
#12
Yu-Chi Bai, Yu-Chun Hsia, Yu-Ting Lin, Kuan-Hao Chen, Fong-In Chou, Chia-Min Yang, Yung-Jen Chuang
BACKGROUND: Feasibility and efficacy of boric acid (BA)-mediated boron neutron capture therapy (BNCT) was first demonstrated by eliminating hepatocellular carcinoma (HCC) in a rat model. Furthermore, selective uptake of BA by liver tumor cells was shown in a rabbit model. To gain further insight, this study aimed to investigate the mechanisms of transportation and selective uptake of BA in HepG2 liver tumor cells. MATERIALS AND METHODS: Transportation of BA in HepG2 cells was analyzed by time-course assays and by analyzing the rate of diffusion versus the concentration of BA...
November 2017: Anticancer Research
https://www.readbyqxmd.com/read/29036572/dose-effect-of-the-33s-n-%C3%AE-30si-reaction-in-bnct-using-the-new-n_tof-cern-data
#13
M Sabaté-Gilarte, J Praena, I Porras, J M Quesada
33S is a stable isotope of sulphur which is being studied as a potential cooperative target for Boron Neutron Capture Therapy (BNCT) in accelerator-based neutron sources because of its large (n,α) cross section in the epithermal neutron energy range. Previous measurements resolved the resonances with a discrepant description of the lowest-lying and strongest one (at 13.5 keV). However, the evaluations of the major databases do not include resonances, except EAF-2010 which shows smaller values in this range than the experimental data...
September 23, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29034910/from-boron-clusters-to-gold-clusters-new-label-free-colorimetric-sensors
#14
Bin Qi, Chenchen Wu, Ling Xu, Wenjing Wang, Jin Cao, Jun Liu, Shuai Zhang, Detlef Gabel, Haibo Zhang, Xiaohai Zhou
A fundamental boron cluster, [closo-B12H12](2-), mainly known as an inert agent for boron neutron capture therapy, can also serve as a bi-functional reductant and a capping agent for the formation of monodispersed size-controlled gold nanoparticles (AuNPs) under mild reaction conditions. The obtained AuNPs remained thermo-dynamically stable over 3 months, and exhibited high performance in phase transfer and sensing of heavy metal ions.
August 22, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29021997/dataset-on-the-synthesis-and-characterization-of-boron-fenbufen-and-its-f-18-labeled-homolog
#15
Chun-Nan Yeh, Chi-Wei Chang, Yi-Hsiu Chung, Shi-Wei Tien, Yong-Ren Chen, Tsung-Wen Chen, Ying-Cheng Huang, Hsin-Ell Wang, You-Cheng Chou, Ming-Huang Chen, Kun-Chun Chiang, Wen-Sheng Huang, Chung-Shan Yu
The data presented in this article are related to the research article entitled "Synthesis and Characterization of Boron Fenbufen and its F-18 Labeled Homolog for Boron Neutron Capture Therapy of COX-2 Overexpressed Cholangiocarcinoma". The contents of the data article include 1) the set up for performing in vitro binding assay, 2) (1)H-, (13)C- and (19)F-NMR of compounds described in main text, 3) HPLC chromatogram of the fluorination mixtures, 4) data of in vitro stability test, cell survival assay, western blot and PCR analysis, 5) the modules for fixing the two CCA rats for BNCT, and 6) bar diagram for tumor reduction using [(18)F]FDG-PET 24 h post treatment with BNCT...
December 2017: Data in Brief
https://www.readbyqxmd.com/read/28888921/n-4-b-4-4-5-5-tetramethyl-1-3-2-dioxaborolan-methyl-2-deoxycytidine-as-a-potential-boron-delivery-agent-with-respect-to-glioblastoma
#16
Łukasz Uram, Joanna Nizioł, Piotr Maj, Justyna Sobich, Wojciech Rode, Tomasz Ruman
Glioblastoma multiforme (GBM) is a central nervous system tumor of grade IV, according to the WHO classification, extremely resistant to all currently used forms of therapy, including resection, radiotherapy, chemotherapy or combined therapy. Therefore, more effective treatment strategies of this tumor are needed, with boron neutron capture therapy (BNCT) being a potential solution, provided a proper cancer cells-targeted 10B delivery agent is found. In search of such an agent, toxicity and capacity to target DNA of a boronated derivative of 2'-deoxycytidine, N(4)-[B-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan)methyl]-2'-deoxycytidine (1), was tested against human tumor vs...
November 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28886331/towards-carborane-functionalised-structures-for-the-treatment-of-brain-cancer
#17
REVIEW
Gianpiero Calabrese, Anis Daou, Eugen Barbu, John Tsibouklis
Boron neutron capture therapy (BNCT) is a promising targeted chemoradiotherapeutic technique for the management of invasive brain tumors, such as glioblastoma multiforme (GBM). A prerequisite for effective BNCT is the selective targeting of tumour cells with (10)B-rich therapeutic moieties. To this end, polyhedral boranes, especially carboranes, have received considerable attention because they combine a high boron content with relative low toxicity and metabolic inertness. Here, we review progress in the molecular design of recently investigated carborane derivatives in light of the widely accepted performance requirements for effective BNCT...
September 5, 2017: Drug Discovery Today
https://www.readbyqxmd.com/read/28871389/boron-neutron-capture-therapy-bnct-translational-studies-in-the-hamster-cheek-pouch-model-of-oral-cancer-at-the-new-b2-configuration-of-the-ra-6-nuclear-reactor
#18
Andrea Monti Hughes, Juan Longhino, Esteban Boggio, Vanina A Medina, Diego J Martinel Lamas, Marcela A Garabalino, Elisa M Heber, Emiliano C C Pozzi, María E Itoiz, Romina F Aromando, David W Nigg, Verónica A Trivillin, Amanda E Schwint
Boron neutron capture therapy (BNCT) is based on selective accumulation of B-10 carriers in tumor followed by neutron irradiation. We demonstrated, in 2001, the therapeutic effect of BNCT mediated by BPA (boronophenylalanine) in the hamster cheek pouch model of oral cancer, at the RA-6 nuclear reactor. Between 2007 and 2011, the RA-6 was upgraded, leading to an improvement in the performance of the BNCT beam (B2 configuration). Our aim was to evaluate BPA-BNCT radiotoxicity and tumor control in the hamster cheek pouch model of oral cancer at the new "B2" configuration...
November 2017: Radiation and Environmental Biophysics
https://www.readbyqxmd.com/read/28862209/accelerator-driven-neutron-source-design-via-beryllium-target-and-208-pb-moderator-for-boron-neutron-capture-therapy-in-alternative-treatment-strategy-by-monte-carlo-method
#19
Abdollah Khorshidi
AIMS: The reactor has increased its area of application into medicine especially boron neutron capture therapy (BNCT); however, accelerator-driven neutron sources can be used for therapy purposes. The present study aimed to discuss an alternative method in BNCT functions by a small cyclotron with low current protons based on Karaj cyclotron in Iran. MATERIALS AND METHODS: An epithermal neutron spectrum generator was simulated with 30 MeV proton energy for BNCT purposes...
July 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28858854/photon-iso-effective-dose-for-cancer-treatment-with-mixed-field-radiation-based-on-dose-response-assessment-from-human-and-an-animal-model-clinical-application-to-boron-neutron-capture-therapy-for-head-and-neck-cancer
#20
Sara Josefina Gonzalez, Emiliano C C Pozzi, Andrea Monti Hughes, Lucas Provenzano, Hanna Koivunoro, Daniel Germán Carando, Silvia Inés Thorp, Mariana Rosalía Casal, Silva Bortolussi, Verónica A Trivillin, Marcela A Garabalino, Paula Curotto, Elisa M Heber, Gustavo A Santa Cruz, Leena Kankaanranta, Heikki Joensuu, Amanda E Schwint
Boron Neutron Capture Therapy (BNCT) is a treatment modality that combines different radiation qualities. Since the severity of biological damage following irradiation depends on the radiation type, a quantity different from absorbed dose is required to explain effects observed in the clinical BNCT in terms of outcome compared with conventional photon radiation therapy. A new approach for calculating photon iso-effective doses in BNCT was introduced previously. The present work extends this model to include information from dose-response assessments in animal models and humans...
August 31, 2017: Physics in Medicine and Biology
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