keyword
https://read.qxmd.com/read/38463503/the-status-and-challenges-for-prostate-sbrt-treatments-in-united-states-proton-therapy-centers-an-nrg-oncology-practice-survey
#21
Jiajian Shen, Paige A Taylor, Carlos E Vargas, Minglei Kang, Jatinder Saini, Jun Zhou, Peilong Wang, Wei Liu, Charles B Simone Ii, Ying Xiao, Liyong Lin
A survey was designed to inquire about the practice of proton SBRT treatment for prostate cancer. The survey was distributed to all 30 proton therapy centers in the United States that participate in the National Clinical Trial Network in Feb. 2023. The survey focused on usage, patient selection criteria, prescriptions, target contours, dose constraints, treatment plan optimization and evaluation methods, patient-specific QA, and IGRT methods. Results: We received responses from 25 centers (83% participation)...
February 27, 2024: ArXiv
https://read.qxmd.com/read/38461635/comparing-interplay-effects-in-scanned-proton-therapy-of-lung-cancer-free-breathing-with-various-layer-and-volume-rescanning-versus-respiratory-gating-with-different-gate-widths
#22
JOURNAL ARTICLE
Yuki Tominaga, Masaki Suga, Mikuni Takeda, Yuki Yamamoto, Takashi Akagi, Takahiro Kato, Sunao Tokumaru, Michinori Yamamoto, Masataka Oita
PURPOSE: We investigated interplay effects and treatment time (TT) in scanned proton therapy for lung cancer patients. We compared free-breathing (FB) approaches with multiple rescanning strategies and respiratory-gating (RG) methods with various gating widths to identify the superior irradiation technique. METHODS: Plans were created with 4/1, 2/2, and 1/4 layered/volume rescans of FB (L4V1, L2V2, and L1V4), and 50%, 30%, and 10% gating widths of the total respiratory curves (G50, G30, and G10) of the RG plans with L4V1...
March 9, 2024: Physica Medica: PM
https://read.qxmd.com/read/38459823/genomic-analysis-of-an-aggressive-hepatic-leiomyosarcoma-case-following-treatment-for-hepatocellular-carcinoma
#23
Yuto Numata, Noriyuki Akutsu, Masashi Idogawa, Kohei Wagatsuma, Yasunao Numata, Keisuike Ishigami, Tomoya Nakamura, Takehiro Hirano, Yujiro Kawakami, Yoshiharu Masaki, Ayako Murota, Shigeru Sasaki, Hiroshi Nakase
A 70-year-old man undergoing treatment for immunoglobulin G4-related disease developed a liver mass on computed tomography during routine imaging examination. The tumor was located in the hepatic S1/4 region, was 38 mm in size, and showed arterial enhancement on dynamic contrast-enhanced computed tomography. We performed a liver biopsy and diagnosed moderately differentiated hepatocellular carcinoma. The patient underwent proton beam therapy. The tumor remained unchanged but enlarged after 4 years...
March 9, 2024: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://read.qxmd.com/read/38456622/a-prototype-scintillator-real-time-beam-monitor-for-ultra-high-dose-rate-radiotherapy
#24
JOURNAL ARTICLE
Daniel S Levin, Peter S Friedman, Claudio Ferretti, Nicholas Ristow, Monica Tecchio, Dale W Litzenberg, Vladimir Bashkirov, Reinhard Schulte
BACKGROUND: FLASH Radiotherapy (RT) is an emergent cancer RT modality where an entire therapeutic dose is delivered at more than 1000 times higher dose rate than conventional RT. For clinical trials to be conducted safely, a precise and fast beam monitor that can generate out-of-tolerance beam interrupts is required. This paper describes the overall concept and provides results from a prototype ultra-fast, scintillator-based beam monitor for both proton and electron beam FLASH applications...
March 8, 2024: Medical Physics
https://read.qxmd.com/read/38454657/development-of-a-digital-star-shot-analysis-system-for-comparing-radiation-and-imaging-isocenters-of-proton-treatment-machine
#25
JOURNAL ARTICLE
Ji Hye Han, Kwanghyun Jo
PURPOSE: To directly compare the radiation and imaging isocenters of a proton treatment machine, we developed and evaluated a real-time radiation isocenter verification system. METHODS: The system consists of a plastic scintillator (PI-200, Mitsubishi Chemical Corporation, Tokyo, Japan), an acrylic phantom, a steel ball on the detachable plate, Raspberry Pi 4 (Raspberry Pi Foundation, London, UK) with camera module, and analysis software implemented through a Python-based graphical user interface (GUI)...
March 7, 2024: Journal of Applied Clinical Medical Physics
https://read.qxmd.com/read/38452383/fano-cavity-test-and-investigation-of-the-response-of-the-roos-chamber-irradiated-by-proton-beams-in-perpendicular-magnetic-fields-up-to-1-t
#26
JOURNAL ARTICLE
Isabel Blum, Jing Syuen Wong, Krishna Godino Padre, Jessica Stolzenberg, Hermann Fuchs, Kilian-Simon Baumann, Bjoern Poppe, Hui Khee Looe
OBJECTIVE: The aim of this work is to investigate the response of the Roos chamber (type 34001) irradiated by clinical proton beams in magnetic fields. APPROACH: At first, a Fano test was implemented in Monte Carlo software package GATE version 9.2 (based on Geant4 version 11.0.2) using a cylindrical slab geometry in a magnetic field up to 1 T. In accordance to an experimental setup (Fuchs et al 2021), the magnetic field correction factors kB Q of the Roos chamber were determined at different energies up to 252 MeV and magnetic field strengths up to 1 T, by separately simulating the ratios of chamber signals MQ /MB Q , without and with magnetic field, and the dose-conversion factors DB w,Q /Dw,Q in a small cylinder of water, with and without magnetic field...
March 7, 2024: Physics in Medicine and Biology
https://read.qxmd.com/read/38444671/prospective-study-investigating-hypofractionated-proton-beam-therapy-in-patients-with-inoperable-early-stage-non-small-cell-lung-cancer
#27
JOURNAL ARTICLE
Kyungmi Yang, Jae Myoung Noh, Hye Yun Park, Hongseok Yoo, Sun Hye Shin, Hongryull Pyo
PURPOSE: To report the results of hypofractionated proton beam therapy (PBT) for the treatment of early stage lung cancer in patients not suitable for surgical resection. METHODS: Data from 27 adult patients, who were diagnosed with inoperable cT1-3N0 non-small cell lung cancer (NSCLC) between March 2018 and August 2020, were analyzed. PBT was prescribed as 64 Cobalt Grey equivalents delivered in 8 fractions (Sumitomo, Japan). The primary endpoint was local control; secondary endpoints included overall survival, quality of life, and grade ≥3 toxicity...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38441841/correction-to-the-effectiveness-and-safety-of-proton-beam-radiation-therapy-in-children-and-young-adults-with-central-nervous-system-cns-tumours-a-systematic-review
#28
Jayne S Wilson, Caroline Main, Nicky Thorp, Roger E Taylor, Saimma Majothi, Pamela R Kearns, Martin English, Madhumita Dandapani, Robert Phillips, Keith Wheatley, Barry Pizer
No abstract text is available yet for this article.
March 5, 2024: Journal of Neuro-oncology
https://read.qxmd.com/read/38422545/imaging-and-characterization-of-optical-emission-from-ex-vivo-tissue-during-conventional-and-uhdr-pbs-proton-therapy
#29
JOURNAL ARTICLE
Roman Vasyltsiv, Mahbubur Rahman, Joseph Harms, Megan Alexandra Clark, David Gladstone, Brian W Pogue, Rongxiao Zhang, Petr Bruza

Surface luminescence imaging is a promising technique for real-time visualization of treatment delivery, offering applications in dose verification, treatment monitoring, and retrospective treatment plan comparison. This research aims to explore the feasibility of surface imaging during proton therapy, under conventional and UHDR conditions. 

Approach: Conventional and UHDR PBS proton therapy irradiation of porcine tissue and plastic tissue phantom was imaged using intensified CMOS cameras...
February 29, 2024: Physics in Medicine and Biology
https://read.qxmd.com/read/38421306/phantosmia-during-proton-radiation-and-differences-in-frequency-of-phantosmia-rates-based-on-proton-craniospinal-irradiation-technique-for-pediatric-brain-tumor-patients
#30
JOURNAL ARTICLE
Myrsini Ioakeim-Ioannidou, Juliane Daartz, Parsa Erfani, Tobias Urell, Arthur Lalonde, Julia Berv, Shannon Leahy, Barbara Fullerton, Rachel Bolton, Torunn Yock, Nancy Tarbell, Beow Yeap, Shannon M MacDonald
BACKGROUND: Unusual olfactory perception, often referred to as "phantosmia" or "cacosmia" has been reported during brain radiotherapy (RT), but is infrequent and does not typically interfere with the ability to deliver treatment. We seek to determine the rate of phantosmia for patients treated with proton craniospinal irradiation (CSI) and identify any potential clinical or treatment-related associations. METHODS: We performed a retrospective review of 127 pediatric patients treated with CSI, followed by a boost to the brain for primary brain tumors in a single institution between 2016 and 2021...
February 29, 2024: Pediatric Blood & Cancer
https://read.qxmd.com/read/38417182/machine-learning-approach-for-proton-range-verification-using-real-time-prompt-gamma-imaging-with-compton-cameras-addressing-the-total-deposited-energy-information-gap
#31
JOURNAL ARTICLE
Majid Kazemi Kozani
OBJECTIVE: Compton camera imaging shows promise as a range verification technique in proton therapy. This work aims to assess the performance of a machine learning model in Compton camera imaging for proton beam range verification improvement. APPROACH: The presented approach was used to recognize Compton events and estimate more accurately the prompt gamma (PG) energy in the Compton camera to reconstruct the PGs emission profile during proton therapy. This work reports the results obtained from the GEANT4 simulation for a proton beam impinging on a polymethyl methacrylate (PMMA) target...
February 28, 2024: Physics in Medicine and Biology
https://read.qxmd.com/read/38415848/pencil-beam-scanning-proton-therapy-for-mediastinal-lymphomas-in-deep-inspiration-breath-hold-a-retrospective-assessment-of-plan-robustness
#32
JOURNAL ARTICLE
Filip Hörberger, Karin M Andersson, Marika Enmark, Ingrid Kristensen, Anna Flejmer, Anneli Edvardsson
PURPOSE/BACKGROUND: The aim of this study was to evaluate pencil beam scanning (PBS) proton therapy (PT) in deep inspiration breath-hold (DIBH) for mediastinal lymphoma patients, by retrospectively evaluating plan robustness to the clinical target volume (CTV) and organs at risk (OARs) on repeated CT images acquired throughout treatment.  Methods: Sixteen mediastinal lymphoma patients treated with PBS-PT in DIBH were included. Treatment plans (TPs) were robustly optimized on the CTV (7 mm/4...
February 28, 2024: Acta Oncologica
https://read.qxmd.com/read/38409947/mri-based-radiomic-features-for-identifying-recurrent-prostate-cancer-after-proton-radiation-therapy
#33
JOURNAL ARTICLE
Kazim Z Gumus, Samuel Serrano Contreras, Mohammed Al-Toubat, Ira Harmon, Mauricio Hernandez, Savas Ozdemir, Sindhu Kumar, Nurcan Yuruk, Mutlu Mete, K C Balaji, Mark Bandyk, Dheeraj R Gopireddy
PURPOSE: Magnetic Resonance Imaging (MRI) evaluation of recurrent prostate cancer (PCa) following proton beam therapy is challenging due to radiation-induced tissue changes. This study aimed to evaluate MRI-based radiomic features so as to identify the recurrent PCa after proton therapy. METHODS: We retrospectively studied 12 patients with biochemical recurrence (BCR) following proton therapy. Two experienced radiologists identified prostate lesions from multi-parametric MRI (mpMRI) images post-proton therapy and marked control regions of interest (ROIs) on the contralateral side of the prostate gland...
February 26, 2024: Journal of Applied Clinical Medical Physics
https://read.qxmd.com/read/38406918/salvage-skull-base-surgery-after-proton-beam-therapy-for-recurrent-sinonasal-malignancies-a-retrospective-study
#34
JOURNAL ARTICLE
Shinichi Okada, Takashi Mukaigawa, Seiya Goto, Yohei Hiiragi, Fuyuki Sato, Shoichi Deguchi, Hirofumi Ogawa, Tsuyoshi Onoe, Shigeyuki Murayama, Yoshichika Yasunaga, Nakamasa Hayashi
BACKGROUND: This study aimed to examine treatment outcomes and postoperative complications associated with salvage skull base surgery following radical proton beam therapy (PBT). METHODS: Nine patients who underwent salvage skull base surgery following curative PBT as the initial treatment at our institution between September 2002 and May 2023 were retrospectively reviewed. RESULTS: The cohort comprised four males and five females with a mean age of 48...
February 26, 2024: Head & Neck
https://read.qxmd.com/read/38405431/robustness-and-dosimetric-verification-of-hippocampal-sparing-craniospinal-pencil-beam-scanning-proton-plans-for-pediatric-medulloblastoma
#35
JOURNAL ARTICLE
Anneli Edvardsson, Jenny Gorgisyan, Karin M Andersson, Christina Vallhagen Dahlgren, Alexandru Dasu, Daniel Gram, Thomas Björk-Eriksson, Per Munck Af Rosenschöld
BACKGROUND AND PURPOSE: Hippocampal-sparing (HS) is a method that can potentially reduce late cognitive complications for pediatric medulloblastoma (MB) patients treated with craniospinal proton therapy (PT). The aim of this study was to investigate robustness and dosimetric plan verification of pencil beam scanning HS PT. MATERIALS AND METHODS: HS and non-HS PT plans for the whole brain part of craniospinal treatment were created for 15 pediatric MB patients. A robust evaluation of the plans was performed...
January 2024: Physics and Imaging in Radiation Oncology
https://read.qxmd.com/read/38405428/effects-of-modern-aesthetic-dental-fillings-on-proton-therapy
#36
JOURNAL ARTICLE
Yun Ming Wong, Calvin Wei Yang Koh, Kah Seng Lew, Clifford Ghee Ann Chua, Ping Lin Yeap, Wibawa Andrew, Master Zubin, Sharon Shuxian Poh, Wen Siang Lew, James Cheow Lei Lee, Sung Yong Park, Hong Qi Tan
BACKGROUND AND PURPOSE: High-density dental fillings pose a non-negligible impact on head and neck cancer treatment. For proton therapy, stopping power ratio (SPR) prediction will be significantly impaired by the associated image artifacts. Dose perturbation is also inevitable, compromising the treatment plan quality. While plenty of work has been done on metal or amalgam fillings, none has touched on composite resin (CR) and glass ionomer cement (GIC) which have seen an increasing usage...
January 2024: Physics and Imaging in Radiation Oncology
https://read.qxmd.com/read/38405317/five-year-outcomes-of-a-phase-1-2-trial-of-accelerated-partial-breast-irradiation-using-proton-therapy-for-women-with-stage-0-iia-breast-cancer
#37
JOURNAL ARTICLE
Gary M Freedman, Taoran Li, Elizabeth Garver, Katherine Shillington, Bridget Shinkle, Julia C Tchou, Oluwadamilola M Fayanju, Lilie Lin, Neil K Taunk
PURPOSE: We report the results of a phase 1/2 trial of external beam partial breast radiation using proton therapy. METHODS AND MATERIALS: Eligible patients included stage 0-IIA breast cancer pTis-T2, N0, and size ≤3 cm. Proton beam radiation was used to deliver 3.85 Gy twice daily to 38.5 Gy. The phase 1 portion determined feasibility based on criteria of successful plan creation, treatment delivery, and acute toxicity grade ≥3 in ≤20% of patients...
February 2024: Advances in Radiation Oncology
https://read.qxmd.com/read/38405315/comparative-evaluation-of-proton-therapy-and-volumetric-modulated-arc-therapy-for-brachial-plexus-sparing-in-the-comprehensive-reirradiation-of-high-risk-recurrent-breast-cancer
#38
JOURNAL ARTICLE
J Isabelle Choi, Beryl McCormick, Peter Park, Mark Millar, Katherine Walker, Chih Chun Tung, Sheng Huang, Peter Florio, Chin-Cheng Chen, Alicia Lozano, Alexandra L Hanlon, Jana Fox, Amy J Xu, Melissa Zinovoy, Boris Mueller, Richard Bakst, Quincey LaPlant, Lior Z Braunstein, Atif J Khan, Simon N Powell, Oren Cahlon
PURPOSE: Recurrent or new primary breast cancer requiring comprehensive regional nodal irradiation after prior radiation therapy (RT) to the supraclavicular area and upper axilla is challenging due to cumulative brachial plexus (BP) dose tolerance. We assessed BP dose sparing achieved with pencil beam scanning proton therapy (PBS-PT) and photon volumetric modulated arc therapy (VMAT). METHODS AND MATERIALS: In an institutional review board-approved planning study, all patients with ipsilateral recurrent breast cancer treated with PBS-PT re-RT (PBT1) with at least partial BP overlap from prior photon RT were identified...
February 2024: Advances in Radiation Oncology
https://read.qxmd.com/read/38400611/single-high-energy-arc-proton-therapy-with-bragg-peak-boost-sharp
#39
JOURNAL ARTICLE
Scott N Penfold, Alexandre M C Santos, Melanie Penfold, Emma Shierlaw, Rosanna Crain
INTRODUCTION: Because of the co-location of critical organs at risk, base of skull tumours require steep dose gradients to achieve the prescribed dosimetric criteria. When available, proton beam therapy (PBT) is often considered a desirable modality for these cases, but in many instances, compromises in target coverage are still required to achieve critical organ at risk (OAR) tolerance doses. A number of techniques have been proposed to further improve the penumbra of PBT. In the current study, we propose a novel, collimator-free treatment planning technique that combines high-energy shoot-through proton beams with conventional Bragg peak spot placement...
February 23, 2024: Journal of Medical Radiation Sciences
https://read.qxmd.com/read/38398188/pencil-beam-scanning-proton-bragg-peak-conformal-flash-in-prostate-cancer-stereotactic-body-radiotherapy
#40
JOURNAL ARTICLE
Tyler Kaulfers, Grant Lattery, Chingyun Cheng, Xingyi Zhao, Balaji Selvaraj, Hui Wu, Arpit M Chhabra, Jehee Isabelle Choi, Haibo Lin, Charles B Simone, Shaakir Hasan, Minglei Kang, Jenghwa Chang
Bragg peak FLASH radiotherapy (RT) uses a distal tracking method to eliminate exit doses and can achieve superior OAR sparing. This study explores the application of this novel method in stereotactic body radiotherapy prostate FLASH-RT. An in-house platform was developed to enable intensity-modulated proton therapy (IMPT) planning using a single-energy Bragg peak distal tracking method. The patients involved in the study were previously treated with proton stereotactic body radiotherapy (SBRT) using the pencil beam scanning (PBS) technique to 40 Gy in five fractions...
February 15, 2024: Cancers
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