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Proton beam therapy

Jeong-Eun Rah, Gwe-Ya Kim, Do Hoon Oh, Tae Hyun Kim, Jong Won Kim, Dae Yong Kim, Sung Yong Park, Dongho Shin
BACKGROUND: The purpose of this study is to evaluate the dosimetric benefits of a proton arc technique for treating tumors of the para-aortic lymph nodes (PALN). METHOD: In nine patients, a proton arc therapy (PAT) technique was compared with intensity modulated radiation therapy (IMRT) and proton beam therapy (PBT) techniques with respect to the planning target volume (PTV) and organs at risk (OAR). PTV coverage, conformity index (CI), homogeneity index (HI) and OAR doses were compared...
October 21, 2016: Radiation Oncology
Adepitan A Owosho, SaeHee K Yom, Zhiqiang Han, Kevin Sine, Nancy Y Lee, Joseph M Huryn, Cherry L Estilo
OBJECTIVE: The purpose of this study was to compare the dosimetric distribution of ipsilateral proton beam radiation therapy (PBRT) with intensity-modulated radiation therapy (IMRT) in the tooth-bearing region of the mandible in patients with head and neck cancer (HNC). STUDY DESIGN: The mandibular dosimetric distribution in patients with head and neck cancer treated with ≥60 Gy relative biologic equivalent PBRT was evaluated. The mean radiation doses were calculated in 5 regions: ipsilateral molar, ipsilateral premolar, anterior, contralateral premolar, and contralateral molar (CM) regions...
November 2016: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Emmanuel Jouglar, Antoine Wagner, Grégory Delpon, Loïc Campion, Philippe Meingan, Valérie Bernier, Charlotte Demoor-Goldschmidt, Marc-André Mahé, Thomas Lacornerie, Stéphane Supiot
OBJECTIVES: Late abdominal irradiation toxicity during childhood included renal damage, hepatic toxicity and secondary diabetes mellitus. We compared the potential of conformal radiotherapy (CRT), helical tomotherapy (HT) and proton beam therapy (PBT) to spare the abdominal organs at risk (pancreas, kidneys and liver- OAR) in children undergoing abdominal irradiation. METHODS: We selected children with abdominal tumors who received more than 10 Gy to the abdomen...
2016: PloS One
Arun D Singh, William J Dupps, Charles V Biscotti, John H Suh, Kira L Lathrop, John P Nairn, Helen Shih
PURPOSE: To report the outcome after limbal stem cell preservation during proton beam irradiation for diffuse iris melanoma. METHODS: This is a single-case report of diffuse iris melanoma that was managed with proton beam radiation (53 Gy), wherein preemptively harvested superior and inferior limbal stem cells before radiation were replaced after irradiation. Regeneration of the palisades of Vogt and the limbal stem cells was documented by an optical coherence tomography-based imaging protocol...
October 14, 2016: Cornea
Pietro Valerio Foti, Antonio Longo, Michele Reibaldi, Andrea Russo, Giuseppe Privitera, Corrado Spatola, Luigi Raffaele, Vincenzo Salamone, Renato Farina, Stefano Palmucci, Andrea Musumeci, Rosario Caltabiano, Marco Ragusa, Cesare Mariotti, Teresio Avitabile, Pietro Milone, Giovanni Carlo Ettorre
PURPOSE: The purpose of this prospective study was to investigate the proton-beam-induced changes in apparent diffusion coefficient (ADC) values of ocular melanoma treated with proton-beam therapy (PBT) in patients undergoing long-term magnetic resonance imaging (MRI) follow-up and to assess whether variations in ADC constitute a reliable biomarker for predicting and detecting the response of ocular melanoma to PBT. METHODS: Seventeen patients with ocular melanoma treated with PBT were enrolled...
October 17, 2016: La Radiologia Medica
Daniel Sanchez-Parcerisa, Maura Kirk, Marcus Fager, Brendan Burgdorf, Malorie Stowe, Tim Solberg, Alejandro Carabe
The development of rotational proton therapy plans based on a pencil-beam-scanning (PBS) system has been limited, among several other factors, by the energy-switching time between layers, a system-dependent parameter that ranges between a fraction of a second and several seconds. We are investigating mono- and bi-energetic rotational proton modulated arc therapy (PMAT) solutions that would not be affected by long energy switching times. In this context, a systematic selection of the optimal proton energy for each arc is vital...
October 14, 2016: Physics in Medicine and Biology
Brent F B Huisman, J M Létang, É Testa, D Sarrut
There is interest in the particle therapy community in using prompt gammas (PGs), a natural byproduct of particle treatment, for range verification and eventually dose control. However, PG production is a rare process and therefore estimation of PGs exiting a patient during a proton treatment plan executed by a Monte Carlo (MC) simulation converges slowly. Recently, different approaches to accelerating the estimation of PG yield have been presented. Sterpin et al (2015 Phys. Med. Biol. 60 4915-46) described a fast analytic method, which is still sensitive to heterogeneities...
October 14, 2016: Physics in Medicine and Biology
Ei-Ichiro Takaoka, Jun Miyazaki, Hitoshi Ishikawa, Koji Kawai, Tomokazu Kimura, Ryutaro Ishitsuka, Takahiro Kojima, Reiko Kanuma, Daichi Takizawa, Toshiyuki Okumura, Hideyuki Sakurai, Hiroyuki Nishiyama
OBJECTIVE: We retrospectively elucidated the oncological outcomes, prognostic factors and toxicities of proton beam therapy in trimodal bladder-preserving therapy for muscle-invasive bladder cancer at our institution. METHODS: From 1990 to 2015, 70 patients with cT2-3N0M0 muscle-invasive bladder cancer underwent trimodal bladder-preserving therapy consisting of maximal transurethral resection of the bladder tumor, small pelvis photon irradiation, intra-arterial chemotherapy and proton beam therapy...
October 13, 2016: Japanese Journal of Clinical Oncology
Joseph Frankl, Cassi Grotepas, Baldassare Stea, G Michael Lemole, Alexander Chiu, Rihan Khan
BACKGROUND: Chordoma is a rare invasive bone tumor that may occur anywhere along the neuraxis. A total of three primary histological varieties have been identified: conventional, chondroid, and dedifferentiated. CASE PRESENTATION: We report a case of an 8-year-old white girl who presented with conventional chordoma, was treated with surgical resection and mixed proton and photon beam therapy, and had a recurrence in the resection cavity 2.5 years later with dedifferentiated morphology...
October 12, 2016: Journal of Medical Case Reports
Ye Zhang, Isabel Huth, Martin Wegner, Damien Charles Weber, Antony John Lomax
BACKGROUND AND PURPOSE: The treatment quality of pencil beam scanned (PBS) proton therapy to mobile tumour treatments can be compromised due to interplay effects. The aim of this work is to systematically evaluate the effectiveness of rescanning for liver tumour treatments for a commercial PBS delivery system. MATERIALS AND METHODS: Plans were calculated to patient specific ITV's (2GyRBE), using spot spacings of 4 and 8mm for 1- and 3-field plans. 4D dose calculations were performed using regular and irregular motion extracted from nine 4DCT(MRI) liver datasets with 4 different starting phases...
October 7, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Kosj Yamoah, Peter As Johnstone
Proton beam therapy has recently become available to a broader population base. There remains much controversy about its routine use in prostate cancer. We provide an analysis of the existing literature regarding efficacy and toxicity of the technique. Currently, the use of proton beam therapy for prostate cancer is largely dependent on continued reimbursement for the practice. While there are potential benefits supporting the use of protons in prostate cancer, the low risk of toxicity using existing techniques and the high cost of protons contribute to lower the value of the technique...
2016: OncoTargets and Therapy
Nan Qin, Pablo Botas, Drosoula Giantsoudi, Jan Schuemann, Zhen Tian, Steve B Jiang, Harald Paganetti, Xun Jia
Monte Carlo (MC) simulation is commonly considered as the most accurate dose calculation method for proton therapy. Aiming at achieving fast MC dose calculations for clinical applications, we have previously developed a graphics-processing unit (GPU)-based MC tool, gPMC. In this paper, we report our recent updates on gPMC in terms of its accuracy, portability, and functionality, as well as comprehensive tests on this tool. The new version, gPMC v2.0, was developed under the OpenCL environment to enable portability across different computational platforms...
October 3, 2016: Physics in Medicine and Biology
Fatemeh S Rasouli, S Farhad Masoudi
PURPOSE: Pre-clinical tests and simulation studies for radiotherapy are generally carried out using water or simplified materials. Investigating the effects of defining compositionally realistic media in proton transport studies is the objective of this work. Accurate modeling of the Bragg curve is a fundamental requirement for such a study. METHODS AND MATERIALS: An equation previously validated by experiments provides an appropriate analytical method for proton dose calculation in depth of the target...
October 3, 2016: International Journal of Radiation Biology
Xin Wang, Falk Poenisch, Narayan Sahoo, Ronald X Zhu, MingFwu Lii, Michael T Gillin, Jing Li, David Grosshans
This is a real case study to minimize the neutron dose equivalent (H) to a fetus using spot scanning proton beams with favorable beam energies and angles. Minimum neutron dose exposure to the fetus was achieved with iterative planning under the guidance of neutron H measurement. Two highly conformal treatment plans, each with three spot scanning beams, were planned to treat a 25-year-old pregnant female with aggressive recurrent chordoma of the base of skull who elected not to proceed with termination. Each plan was scheduled for delivery every other day for robust target coverage...
2016: Journal of Applied Clinical Medical Physics
Tatsuya Inoue, Joachim Widder, Lisanne V van Dijk, Hideki Takegawa, Masahiko Koizumi, Masaaki Takashina, Keisuke Usui, Chie Kurokawa, Satoru Sugimoto, Anneyuko I Saito, Keisuke Sasai, Aart A Van't Veld, Johannes A Langendijk, Erik W Korevaar
PURPOSE: To investigate the impact of setup and range uncertainties, breathing motion, and interplay effects using scanning pencil beams in robustly optimized intensity modulated proton therapy (IMPT) for stage III non-small cell lung cancer (NSCLC). METHODS AND MATERIALS: Three-field IMPT plans were created using a minimax robust optimization technique for 10 NSCLC patients. The plans accounted for 5- or 7-mm setup errors with ±3% range uncertainties. The robustness of the IMPT nominal plans was evaluated considering (1) isotropic 5-mm setup errors with ±3% range uncertainties; (2) breathing motion; (3) interplay effects; and (4) a combination of items 1 and 2...
November 1, 2016: International Journal of Radiation Oncology, Biology, Physics
J W Snider, S Stieb, D Poelma-Tap, L Placidi, F Albertini, A J Lomax, U Kliebsch, D C Weber, R A Schneider
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
M Kountouri, R A Schneider, M Walser, L Vinante, F Fiumedinisi, A Bolsi, A J Lomax, D C Weber
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
S Shimizu, N Katoh, T Hashimoto, K Nishioka, T Yoshimura, S Takao, T Matsuura, N Miyamoto, K Umegaki, H Shirato
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
J W Snider, S Stieb, D Poelma-Tap, L Placidi, F Albertini, A Bolsi, A J Lomax, U Kliebsch, D C Weber, R A Schneider
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
J W Snider, L Mikroutsikos, F Albertini, A Bolsi, M Walser, D C Weber, R A Schneider
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
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