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Proton beam therapy

Ira Seibel, Aline I Riechardt, Katharina Erb-Eigner, Alexander Böker, Dino Cordini, Jens Heufelder, Antonia M Joussen
PURPOSE: This study was performed to show long-term outcomes concerning metastasis rates and local recurrence rates after primary proton beam therapy in uveal melanoma with posterior extraocular extension (EOE) with the main focus on optic nerve invasion. DESIGN: Retrospective case series METHODS: All patients treated with primary proton beam therapy for choroidal or ciliary body melanoma with posterior EOE between July 1998 and August 2010 were included. EOE was either detected upon sonography at primary examination or during the surgical application of tantalum clips onto the sclera...
April 12, 2018: American Journal of Ophthalmology
Youn Joo Choi, Tae Wan Kim, Suzy Kim, Hokyung Choung, Min Joung Lee, Namju Kim, Sang In Khwarg, Young Suk Yu
BACKGROUND: To present our experience on orbital and periorbital tissue changes after proton beam radiation therapy (PBRT) in patients with intraocular tumors, apart from treatment outcomes and disease control. METHODS: Medical records of 6 patients with intraocular tumors who had been treated with PBRT and referred to oculoplasty clinics of two medical centers (Seoul National University Hospital and Seoul Metropolitan Government-Seoul National University Boramae Medical Center) from October 2007 to September 2014 were retrospectively reviewed...
April 16, 2018: Journal of Korean Medical Science
Dayna Bodensteiner
RaySearch Laboratories is a world leader in the field of advanced software and creator of the RayStation treatment planning system for radiation therapy. The aim with RayStation is to deliver an unmatched user experience and leading functionality. Unique features described here include multiatlas based autosegmentation for contouring, deformable registration with 2 different algorithms, multicriteria optimization, Plan Explorer, fallback planning, ultrafast computation speed, and 4-dimensional (4D) adaptive radiation therapy...
April 9, 2018: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
Yuting Lin, El Hassane Bentefour, Jacob B Flanz, Hanne M Kooy, Benjamin M Clasie
Pencil beam scanning (PBS) periodic quality assurance (QA) programs ensure the beam delivered to patients is within technical specifications. Two critical specifications for PBS delivery are the beam width and position. The aim of this study is to investigate whether a 2-dimensional ionization chamber array, such as the MatriXX detector (IBA Dosimetry, Schwarzenbruck, Germany), can be used to characterize submillimeter-sized PBS beam properties. The motivation is to use standard equipment, which may have pixel spacing coarser than the pencil beam size, and simplify QA workflow...
April 12, 2018: Physics in Medicine and Biology
Takeshi Arimura, Takashi Yoshiura, Kyoko Matsukawa, Naoaki Kondo, Ikumi Kitano, Takashi Ogino
The role of proton beam therapy (PBT) as monotherapy for localized prostate cancer (PCa) remains unclear. The purpose of this study was to evaluate the efficacy and adverse events of PBT alone for these patients. Between January 2011 and July 2014, 218 patients with intermediate- and high-risk PCa who declined androgen deprivation therapy (ADT) were enrolled to the study and were treated with PBT following one of the following protocols: 74 Gray (GyE) with 37 fractions (fr) (74 GyE/37 fr), 78 GyE/39 fr, and 70 GyE/28 fr...
April 10, 2018: Cancers
Valentina Ovalle, Eric A Strom, Simona Shaitelman, Karen Hoffman, Richard Amos, George Perkins, Welela Tereffe, Benjamin D Smith, Michael Stauder, Wendy Woodward
Introduction: Accelerated partial breast irradiation (APBI) with protons results in a very different acute effect profile than standard whole breast irradiation. We reviewed our initial experience with proton APBI and felt that a detailed description of these effects were needed to permit a common tool to compare experience with this developing technology. Methods: Sixty sequential patients treated with proton APBI on a prospective protocol were evaluated and 43 patients with a minimum six-month follow-up underwent detailed photographic and radiologic analysis...
April 7, 2018: Cancers
James W Snider, Ralf A Schneider, Davey Poelma-Tap, Sonja Stieb, Fritz R Murray, Lorenzo Placidi, Francesca Albertini, Antony Lomax, Alessandra Bolsi, Ulrike Kliebsch, Robert Malyapa, Damien C Weber
PURPOSE: To evaluate the efficacy and safety of high-dose pencil-beam scanning proton therapy (PBS-PT) in the adjuvant treatment of spinal chordomas. METHODS AND MATERIALS: Between 1997 and 2015, 100 patients with spinal chordomas (median age, 56 years; range, 25-81 years) were treated with adjuvant PBS-PT at the Paul Scherrer Institute: cervical (n = 46), thoracic (n = 4), lumbar (n = 12), and sacral (n = 38). The majority (88%) received PBS-PT alone rather than combined photon-proton therapy...
May 1, 2018: International Journal of Radiation Oncology, Biology, Physics
Charles C Vu, Thomas B Lanni, Sirisha R Nandalur
PURPOSE: Medicare payments to individual physicians are released annually by the CMS. The purpose of this study is to analyze trends in Medicare reimbursement and work relative value unit (wRVU) production to radiation oncologists. MATERIALS AND METHODS: The Medicare Physician Supplier and Other Provider Public Use File and the CMS Physician Fee Schedule Relative Value Files (to calculate wRVUs) for the calendar years 2012 to 2015 were used in this analysis. Medicare reimbursement was aggregated for each calendar year...
March 31, 2018: Journal of the American College of Radiology: JACR
Martyna Śniegocka, Ewa Podgórska, Przemysław M Płonka, Martyna Elas, Bożena Romanowska-Dixon, Małgorzata Szczygieł, Michał A Żmijewski, Mirosława Cichorek, Anna Markiewicz, Anna A Brożyna, Andrzej T Słominski, Krystyna Urbańska
The focus of the present review is to investigate the role of melanin in the radioprotection of melanoma and attempts to sensitize tumors to radiation by inhibiting melanogenesis. Early studies showed radical scavenging, oxygen consumption and adsorption as mechanisms of melanin radioprotection. Experimental models of melanoma in hamsters and in gerbils are described as well as their use in biochemical and radiobiological studies, including a spontaneously metastasizing ocular model. Some results from in vitro studies on the inhibition of melanogenesis are presented as well as radio-chelation therapy in experimental and clinical settings...
April 1, 2018: International Journal of Molecular Sciences
Fahed Alsanea, Landon Wootton, Narayan Sahoo, Rajat Kudchadker, Usama Mahmood, Sam Beddar
In vivo skin dosimetry is desirable in passive scattering proton therapy because of the possibility of high entrance dose with a small number of fields. However, suitable detectors are needed to determine skin dose in proton therapy. Plastic scintillation detectors (PSDs) are particularly well suited for applications in proton therapy because of their water equivalence, small size, and ease of use. We investigated the utility of the Exradin W1, a commercially available PSD, for in vivo skin dosimetry during passive scattering proton therapy...
March 2018: Physica Medica: PM
Tatsuya Miyazaki, Makoto Sohda, Makoto Sakai, Yuji Kumakura, Tomonori Yoshida, Kengo Kuriyama, Takehiko Yokobori, Masaya Miyazaki, Junko Hirato, Toshiyuki Okumura, Hitoshi Ishikawa, Hideyuki Sakurai, Hiroyuki Kuwano
A 50-year-old man who presented with a fever and epigastralgia was diagnosed to have esophageal carcinoma which was identified as poorly differentiated adenocarcinoma producing AFP with Barrett's esophagus. Computed tomography revealed multiple liver metastases and lymph node metastases surrounding the stomach. We first performed chemotherapy for the systemic lesions and proton beam therapy for the local control of lesions without complete remission and we were able to successfully control the frequently recurring lesions by proton beam therapy, cryotherapy and chemotherapy...
March 30, 2018: Internal Medicine
Jiankui Yuan, Rodney Ellis, Mitchell Machtay
PURPOSE: To demonstrate and develop a Monte Carlo (MC) simulation model for a passive double scattering compact proton therapy system based on limited information of the mechanical components. METHOD: We built a virtual machine source model (VMSM) which included a detailed definition of each beam-modifying component in the nozzle. Conceptually, it is similar to the conventional virtual analytical source model (VASM), except that the numerical machine nozzle or beamline is constructed in the VMSM whereas in the VASM analytical parameters characterizing the energy spectrum and source fluence distribution are sought...
March 30, 2018: Medical Physics
Armin Lühr, Cläre von Neubeck, Mechthild Krause, Esther G C Troost
No abstract text is available yet for this article.
February 2018: Clinical and Translational Radiation Oncology
J Miszczyk, K Rawojć, A Panek, A Borkowska, P G S Prasanna, M M Ahmed, J Swakoń, A Gałaś
Purpose: Significant progress has been made in the technological and physical aspects of dose delivery and distribution in proton therapy. However, mode of cell killing induced by protons is less understood in comparison with X-rays. The purpose of this study is to see if there is any difference in the mode of cell-killing, induced by protons and X-rays in an ex vivo human peripheral blood lymphocyte (HPBL) model. Materials and methods: HPBL were irradiated with 60 MeV proton beam or 250-kVp X-rays in the dose range of 0...
February 2018: Clinical and Translational Radiation Oncology
Rami A El Shafie, Maja Czech, Kerstin A Kessel, Daniel Habermehl, Dorothea Weber, Stefan Rieken, Nina Bougatf, Oliver Jäkel, Jürgen Debus, Stephanie E Combs
BACKGROUND: Meningiomas of the skull base account for 25-30% of all meningiomas. Due to the complex structure of the cranial base and its close proximity to critical structures, surgery is often associated with substantial morbidity. Treatment options include observation, aggressive surgical intervention, stereotactic or conventional radiotherapy. In this analysis we evaluate the outcome of 110 patients with meningiomas of the skull base treated with particle therapy. It was performed within the framework of the "clinical research group heavy ion therapy" and supported by the German Research Council (DFG, KFO 214)...
March 27, 2018: Radiation Oncology
Jeong Il Yu, Gyu Sang Yoo, Sungkoo Cho, Sang Hoon Jung, Youngyih Han, Seyjoon Park, Boram Lee, Wonseok Kang, Dong Hyun Sinn, Yong-Han Paik, Geum-Youn Gwak, Moon Seok Choi, Joon Hyeok Lee, Kwang Cheol Koh, Seung Woon Paik, Hee Chul Park
Purpose: This study aimed to evaluate the initial outcomes of proton beam therapy (PBT) for hepatocellular carcinoma (HCC) in terms of tumor response and safety. Materials and Methods: HCC patients who were not indicated for standard curative local modalities and who were treated with PBT at Samsung Medical Center from January 2016 to February 2017 were enrolled. Toxicity was scored using the Common Terminology Criteria for Adverse Events (CTCAE) version 4.0. Tumor response was evaluated using modified Response Evaluation Criteria in Solid Tumors (mRECIST)...
March 29, 2018: Radiation Oncology Journal
Yoshikazu Maeda, Yoshitaka Sato, Satoshi Shibata, Sayuri Bou, Kazutaka Yamamoto, Hiroyasu Tamamura, Nobukazu Fuwa, Shigeyuki Takamatsu, Makoto Sasaki, Yuji Tameshige, Kyo Kume, Hiroki Minami, Yusuke Saga, Makoto Saito
PURPOSE: We quantified interfractional movements of the prostate, seminal vesicles (SVs) and rectum during computed tomography (CT) image-guided proton therapy for prostate cancer and studied the range variation of opposed lateral proton beams. MATERIALS/METHODS: We analyzed 375 sets of daily CT images acquired throughout the proton therapy treatment of 10 patients. We analyzed daily movements of the prostate, SVs and rectum by simulating three image-matching strategies: bone matching, prostate center (PC) matching, and prostate-rectum boundary (PRB) matching...
March 24, 2018: Medical Physics
Cássia O Ribeiro, Antje Knopf, Johannes A Langendijk, Damien C Weber, Antony J Lomax, Ye Zhang
PURPOSE: Respiratory impacts in pencil beam scanned proton therapy (PBS-PT) are accounted by extensive 4D dose calculations, where deformable image registration (DIR) is necessary for estimating deformation vector fields (DVFs). We aim here to evaluate the dosimetric errors induced by different DIR algorithms in their resulting 4D dose calculations by using ground truth(GT)-DVFs from 4DMRI. MATERIALS AND METHODS: Six DIR methods: ANACONDA, Morfeus, B-splines, Demons, CT Deformable, and Total Variation, were respectively applied to nine 4DCT-MRI liver data sets...
March 20, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
B Jones, R G Dale
A summary of the key aspects of radiobiological modelling is provided, based on the theoretical and practical concepts of the linear quadratic (LQ) model, which gradually replaced other numerical approaches. The closely related biological effective dose (BED) concept is useful in many clinical applications. BED formulations in conventional photon-based radiotherapy continue to be developed, and can be extended to the now increasingly used proton and ion-beam therapy, to very low or high dose ranges, the dose rate effect, hypoxia and repopulation...
March 20, 2018: British Journal of Radiology
(no author information available yet)
The use of proton beam therapy (PBT) offers the opportunity to improve greater conformality of radiotherapy treatment delivery in some patients. However, it is associated with a high capital cost and the need to build new dedicated facilities. We discuss how the global radiotherapy community can respond to the challenge of producing high-quality evidence of clinical benefit from PBT in adult patients. In the UK, the National Cancer Research Institute-funded Clinical and Radiotherapy Translational group has established the PBT Clinical Trial Strategy Group...
March 15, 2018: Clinical Oncology: a Journal of the Royal College of Radiologists
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