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Proton beam therapy

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https://www.readbyqxmd.com/read/28211058/a-feasibility-study-of-a-hybrid-breast-immobilization-system-for-early-breast-cancer-in-proton-beam-therapy
#1
Takeshi Arimura, Takashi Ogino, Takashi Yoshiura, Mitsugi Matsuyama, Naoaki Kondo, Hideki Miyazaki, Akari Sakuragi, Takayuki Ohara, Etsuyo Ogo, Yoshio Hishikawa
PURPOSE: We aimed to develop a new breast-immobilizing system for proton beam therapy (PBT) of early breast cancer (EBC) that would provide the optimum breast shape during the treatment as well as increased fixation reliability by reducing the influence of respiratory movement. METHODS: The breast-immobilizing system (HyBIS; Hybrid Breast-Immobilizing System) consists of a whole body immobilization system (WBIS), position converting device (to change patient position), photo scanning system, breast cup (made using a three-dimensional printer), breast cup fitting apparatus, breast cup holding device (to ensure the breast remains lifted in the supine position), and dedicated stretcher fixed to the WBIS (to carry the patient)...
February 16, 2017: Medical Physics
https://www.readbyqxmd.com/read/28202832/-prognostic-impact-of-radiation-therapy-and-molecular-classification-of-infant-atypical-teratoid-rhabdoid-tumors
#2
Yoshihiro Otani, Tomotsugu Ichikawa, Kazuhiko Kurozumi, Takao Yasuhara, Kana Washio, Akira Shimada, Norihisa Katayama, Kuniaki Katsui, Hiroyuki Yanai, Isao Date
Atypical teratoid/rhabdoid tumor(AT/RT)is a rare and lethal childhood cancer. Although radiation therapy in children less than three years of age is generally deferred because of its neural toxicity, recent studies have shown that multimodal therapies, including radiation therapy, are effective in pediatric patients with AT/RT less than three years of age. We treated four infant AT/RT patients and investigated the impact of radiation therapy and genetic classification on the prognosis. The mean age at the time of the operation was 9...
February 2017: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/28198880/proton-therapy-dosimetry-using-the-scintillation-of-the-silica-fibers
#3
Arash Darafsheh, Reza Taleei, Alireza Kassaee, Jarod C Finlay
We investigate the feasibility of proton therapy dose measurement by using scintillation of a bare silica glass fiber. The emission spectra of the optical fiber at various depths in tissue-mimicking phantoms, irradiated with proton beams of energies 100-225 MeV show two distinct peaks at 460 and 650 nm whose nature is connected with the silica point defects. Our experimental results and Monte Carlo simulation showed that the Čerenkov radiation cannot be responsible for such a phenomenon. We showed that the intensity of the peak at 650 nm correlates with the proton dose with a minimal effect of ionization quenching, while the intensity peak at 460 nm under-reports the radiation dose...
February 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28198132/clinical-results-of-proton-beam-therapy-for-hepatocellular-carcinoma-over-5%C3%A2-cm
#4
Kanako Kimura, Tatsuya Nakamura, Takashi Ono, Yusuke Azami, Motohisa Suzuki, Hitoshi Wada, Kanako Takayama, Hiromasa Endo, Teruhito Takeyama, Katsumi Hirose, Yoshihiro Takai, Yasuhiro Kikuchi
PURPOSE: This study was conducted to evaluate the safety and efficacy of proton beam therapy for large hepatocellular carcinoma (HCC). METHODS: Twenty-four patients with a HCC larger than 5.0 cm were treated with proton beam therapy at our institution between 2008 and 2015. RESULTS: The clinical stage was I in 2 patients, II in 9 patients and IIIB in 13 patients. Ten of the 24 patients were not surgical candidates because of advanced HCC or old age...
February 14, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28196271/dose-distribution-at-the-bragg-peak-dose-measurements-using-ebt-and-rtqa-gafchromic-film-set-at-two-positions-to-the-central-beam-axis
#5
Borowicz Dorota Maria, Malicki Julian, Mytsin Gennady, Shipulin Konstantin
AIM: To evaluate the impact of radiochromic film positioning relative to the central beam axis (CAX) in proton beam therapy. Secondarily, to compare the dosimetric measurements obtained by RTQA and EBT film and to compare these to the doses calculated by the treatment planning system (TPS). METHODS: EBT and RTQA dosimetric radiochromic films were immersed in a water phantom and irradiated with a proton beam. The films were placed parallel to the CAX and at a 5º angle on the horizontal plane to assess the effect of film inclination on Bragg peak profiles...
February 14, 2017: Medical Physics
https://www.readbyqxmd.com/read/28182320/proton-beam-therapy-for-bone-sarcomas-of-the-skull-base-and-spine-a-retrospective-nationwide-multicenter-study-in-japan
#6
Yusuke Demizu, Masashi Mizumoto, Tsuyoshi Onoe, Naoki Nakamura, Yasuhiro Kikuchi, Tetsushi Shibata, Tomoaki Okimoto, Sakurai Hideyuki, Tetsuo Akimoto, Kota Ono, Takashi Daimon, Shigeyuki Murayama
We conducted a retrospective, nationwide multicenter study to evaluate the clinical outcomes of proton beam therapy for bone sarcomas of the skull base and spine in Japan. Eligibility criteria included: (1) histologically proven bone sarcomas of the skull base or spine, (2) no metastases, (3) ≥20 years of age, and (4) no prior treatment with radiotherapy. Of the 103 patients treated between January 2004 and January 2012, we retrospectively analyzed data from 96 patients who were followed-up for >6 months or had died within 6 months...
February 9, 2017: Cancer Science
https://www.readbyqxmd.com/read/28166057/proton-therapy-of-prostate-cancer-by-anterior-oblique-beams-implications-of-setup-and-anatomy-variations
#7
M Moteabbed, A Trofimov, G C Sharp, Y Wang, A L Zietman, J A Efstathiou, H-M Lu
Proton therapy of prostate by anterior beams could offer an attractive option for treating patients with hip prosthesis and limiting the high-dose exposure to the rectum. We investigated the impact of setup and anatomy variations on the anterior-oblique (AO) proton plan dose, and strategies to manage these effects via range verification and adaptive delivery. Ten patients treated by bilateral (BL) passive-scattering proton therapy (79.2 Gy in 44 fractions) who underwent weekly verification CT scans were selected...
March 7, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28166055/a-comprehensive-and-efficient-daily-quality-assurance-for-pbs-proton-therapy
#8
O Actis, D Meer, S König, D C Weber, A Mayor
There are several general recommendations for quality assurance (QA) measures, which have to be performed at proton therapy centres. However, almost each centre uses a different therapy system. In particular, there is no standard procedure for centres employing pencil beam scanning and each centre applies a specific QA program. Gantry 2 is an operating therapy system which was developed at PSI and relies on the most advanced technological innovations. We developed a comprehensive daily QA program in order to verify the main beam characteristics to assure the functionality of the therapy delivery system and the patient safety system...
March 7, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28162946/first-clinical-report-of-proton-beam-therapy-for-postoperative-radiotherapy-for-non-small-cell-lung-cancer
#9
Jill S Remick, Caitlin Schonewolf, Peter Gabriel, Abigail Doucette, William P Levin, John C Kucharczuk, Sunil Singhal, Taine T V Pechet, Ramesh Rengan, Charles B Simone, Abigail T Berman
BACKGROUND AND PURPOSE: The characteristic Bragg peak of proton beam therapy (PBT) allows for sparing normal tissues beyond the tumor volume that may allow for decreased toxicities associated with postoperative radiation therapy (PORT). Here we report the first institutional experience with proton therapy for PORT in patients with non-small-cell lung cancer (NSCLC) and assess early toxicities and outcomes. MATERIALS AND METHODS: We identified 61 consecutive patients treated from 2011 to 2014 who underwent PORT for locally advanced NSCLC for positive microscopic margins and/or positive N2 lymph nodes (stage III), with 27 patients receiving PBT and 34 receiving intensity-modulated radiation therapy (IMRT)...
January 5, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/28151727/contour-scanning-for-penumbra-improvement-in-pencil-beam-scanned-proton-therapy
#10
Gabriel Meier, Dominic Leiser, Rico Besson, Alexandre Mayor, Sairos Safai, Damien Weber, Antony Lomax
Proton therapy, especially in the form of pencil beam scanning (PBS), allows for the delivery of highly conformal dose distributions for complex tumor geometries. However, due to scattering of protons inside the patient, lateral dose gradients cannot be arbitrarily steep, which is of importance in cases with organs at risk (OARs) in close proximity to or overlapping planning target volumes (PTVs). In the PBS approach, physical pencil beams are planned using a regular grid orthogonal to the beam direction. In this work, we propose an alternative to this commonly used approach, by defining pencil beams on an irregular grid which is concentric to the target contour...
February 2, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28140380/near-real-time-automated-dose-restoration-in-impt-to-compensate-for-daily-tissue-density-variations-in-prostate-cancer
#11
Thyrza Zeralda Jagt, Sebastiaan Breedveld, Steven van de Water, Ben Heijmen, Mischa Hoogeman
Proton therapy is very sensitive to daily density changes along the pencil beam paths. The purpose of this study is to develop and evaluate an automated method for adaptation of IMPT plans to compensate for these daily tissue density variations. A two-step restoration method for ���densities-of-the-day��� was created: (1) restoration of spot positions (Bragg peaks) by adapting the energy of each pencil beam to the new water equivalent path length; and (2) re-optimization of pencil beam weights by minimizing the dosimetric difference with the planned dose distribution, using a fast and exact quadratic solver...
January 31, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28139305/long-term-outcome-of-phase-i-ii-prospective-study-of-dose-escalated-proton-therapy-for-early-stage-non-small-cell-lung-cancer
#12
Joe Y Chang, Wencheng Zhang, Ritsuko Komaki, Noah C Choi, Shen Chan, Daniel Gomez, Michael O'Reilly, Melenda Jeter, Michael Gillin, Xiaorong Zhu, Xiaodong Zhang, Radhe Mohan, Stephen Swisher, Stephen Hahn, James D Cox
PURPOSE: The aim of this phase I/II study was to assess the long-term clinical benefits and toxicities of proton beam therapy for medically inoperable early-stage non-small cell lung cancer (NSCLC). PATIENTS AND METHODS: From June 2006 to September 2011, 35 patients with medically inoperable T1N0M0 (central or superior location, 12 patients) or T2-3N0M0 (any location, 23 patients) NSCLC were treated with 87.5Gy at 2.5Gy/fraction of proton therapy. Toxicities were scored according to the Common Terminology Criteria for Adverse Events, version 4...
January 27, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28133755/evaluation-of-motion-mitigation-using-abdominal-compression-in-the-clinical-implementation-of-pencil-beam-scanning-proton-therapy-of-liver-tumors
#13
Liyong Lin, Kevin Souris, Minglei Kang, Adam Glick, Haibo Lin, Sheng Huang, Kristin Stützer, Guillaume Janssens, Edmond Sterpin, John A Lee, Timothy D Solberg, James E McDonough, Charles B Simone, Edgar Ben-Josef
PURPOSE: To determine whether individual liver tumor patients can be safely treated with pencil beam scanning proton therapy. This study reports a planning preparation workflow that can be used for beam angle selection and the evaluation of the efficacy of abdominal compression (AC) to mitigate motion. METHODS: Four-dimensional computed tomography scans (4DCT) with and without AC were available from 10 liver tumor patients with fluoroscopy-proven motion reduction by AC, previously treated using photons...
December 9, 2016: Medical Physics
https://www.readbyqxmd.com/read/28133027/-an-85-year-old-man-with-lymph-node-metastasis-of-recurrent-rectal-cancer-treated-usingproton-beam-therapy
#14
Kohei Murata, Tomohiro Kitahara, Yoichiro Nushijima, Shu Okamura, Takayuki Minoji, Rie Hamano, Nariaki Fukuchi, Chikara Ebisui, Tetsu Yanagisawa, Hideoki Yokouchi, Masakatsu Kinuta, Yusuke Demizu, Tomoaki Okimoto
There are few reports that describe the efficacy of proton beam therapy for lymph node metastasis of recurrent rectal cancer, and carbon ion radiotherapy yields higher local tumor control rates. Proton beam therapy needs a longer treatment period but is less toxic to adjacent healthy organs compared to carbon ion radiotherapy. Here we report an 85-year-old man who underwent curative surgery for rectal and sigmoid cancer at the age of 76 years. After 4 years and 2 months, he had liver metastases at S3 and S8, both of which were resected...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28131731/spectroscopic-study-of-prompt-gamma-emission-for-range-verification-in-proton-therapy
#15
Laurent Kelleter, Aleksandra Wrońska, Judith Besuglow, Adam Konefał, Karim Laihem, Johannes Leidner, Andrzej Magiera, Katia Parodi, Katarzyna Rusiecka, Achim Stahl, Thomas Tessonnier
We present the results of an investigation of the prompt-gamma emission from an interaction of a proton beam with phantom materials. Measurements were conducted with a novel setup allowing the precise selection of the investigated depth in the phantom, featuring three different materials composed of carbon, oxygen and hydrogen. We studied two beam energies of 70.54 and 130.87MeV and two detection angles: 90° and 120°. The results are presented in form of profiles of the prompt-gamma yield as a function of depth...
January 25, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28129665/optimization-of-the-mechanical-collimation-for-minibeam-generation-in-proton-minibeam-radiation-therapy
#16
Consuelo Guardiola, Cécile Peucelle, Yolanda Prezado
PURPOSE: The dose tolerances of normal tissues continue to be the main barrier in radiation therapy. To lower it, a novel concept based on a combination of proton therapy and the use of arrays of parallel and thin beams has been recently proposed: proton minibeam radiation therapy (pMBRT). It allies the inherent advantages of protons with the remarkable normal tissue preservation observed when irradiated with submillimetric spatially fractionated beams. Due to multiple Coulomb scattering, the tumor receives a homogeneous dose distribution, while normal tissues in the beam's path benefit from the spatial fractionation of the dose...
January 27, 2017: Medical Physics
https://www.readbyqxmd.com/read/28126270/evisceration-and-ocular-tumors-what-are-the-consequences
#17
S Lemaître, A Lecler, C Lévy-Gabriel, C Reyes, L Desjardins, D Gentien, M Zmuda, P V Jacomet, L Lumbroso-Le Rouic, R Dendale, A Vincent-Salomon, G Pierron, O Galatoire, N Cassoux
PURPOSE: Evisceration can be performed for blind, painful eyes. This surgery can promote the dissemination of tumor cells within the orbit if an ocular tumor has been missed preoperatively. METHODS: We reviewed the medical records of patients who were eviscerated for blind, painful eyes between 2009 and 2014 and who were referred after the surgery to the Institut Curie or the Rothschild Foundation in Paris. We included the patients with a histological diagnosis of ocular tumor or orbital recurrence...
January 23, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28121631/prediction-and-compensation-of-magnetic-beam-deflection-in-mr-integrated-proton-therapy-a-method-optimized-regarding-accuracy-versatility-and-speed
#18
Sonja M Schellhammer, Aswin L Hoffmann
The integration of magnetic resonance imaging (MRI) and proton therapy for on-line image-guidance is expected to reduce dose delivery uncertainties during treatment. Yet, the proton beam experiences a Lorentz force induced deflection inside the magnetic field of the MRI scanner, and several methods have been proposed to quantify this effect. We analyze their structural differences and compare results of both analytical and Monte Carlo models. We find that existing analytical models are limited in accuracy and applicability due to critical approximations, especially including the assumption of a uniform magnetic field...
February 21, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28114125/fragmentation-of-120-and-200-mev-u-1-4-he-ions-in-water-and-pmma-targets
#19
M Rovituso, C Schuy, U Weber, S Brons, M A Cortés-Giraldo, C La Tessa, E Piasetzky, D Izraeli, D Schardt, M Toppi, E Scifoni, M Krämer, M Durante
Recently, the use of (4)He particles in cancer radiotherapy has been reconsidered as they potentially represent a good compromise between protons and (12)C ions. The first step to achieve this goal is the development of a dedicated treatment planning system, for which basic physics information such as the characterization of the beam lateral scattering and fragmentation cross sections are required. In the present work, the attenuation of (4)He primary particles and the build-up of secondary charged fragments at various depths in water and polymethyl methacrylate were investigated experimentally for 120 and 200 MeV u(-1) beams delivered by the synchrotron at the Heidelberg Ion-Beam Therapy Center, Heidelberg...
February 21, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28114124/secondary-radiation-measurements-for-particle-therapy-applications-nuclear-fragmentation-produced-by-4-he-ion-beams-in-a-pmma-target
#20
M Marafini, R Paramatti, D Pinci, G Battistoni, F Collamati, E De Lucia, R Faccini, P M Frallicciardi, C Mancini-Terracciano, I Mattei, S Muraro, L Piersanti, M Rovituso, A Rucinski, A Russomando, A Sarti, A Sciubba, E Solfaroli Camillocci, M Toppi, G Traini, C Voena, V Patera
Nowadays there is a growing interest in particle therapy treatments exploiting light ion beams against tumors due to their enhanced relative biological effectiveness and high space selectivity. In particular promising results are obtained by the use of (4)He projectiles. Unlike the treatments performed using protons, the beam ions can undergo a fragmentation process when interacting with the atomic nuclei in the patient body. In this paper the results of measurements performed at the Heidelberg Ion-Beam Therapy center are reported...
February 21, 2017: Physics in Medicine and Biology
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