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https://www.readbyqxmd.com/read/29161481/-eco-epidemiological-aspects-natural-detection-and-molecular-identification-of-leishmania-spp-in-lutzomyia-reburra-lutzomyia-barrettoi-majuscula-and-lutzomyia-trapidoi
#1
Jazzmín Arrivillaga-Henríquez, Sandra Enríquez, Vanessa Romero, Gustavo Echeverría, Jorge Pérez-Barrera, Ana Poveda, Juan-Carlos Navarro, Alon Warburg, Washington Benítez
INTRODUCTION: The province of Pichincha in Ecuador is an endemic area of cutaneous leishmaniasis, where anthropophilic sand flies with natural infection by Leishmania, have been reported as vectors. However, the role in transmission of zoophilic species has not been evaluated. OBJECTIVE: To evaluate natural infection by Leishmania in two zoophilic phlebotomine sand fly species, Lutzomyia reburra and Lu. barrettoi majuscula, and one anthropophilic species, Lu. trapidoi, as well as the endophagy and synanthropism of these species in the northwest of Pichincha...
March 29, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/29161084/mitochondrial-dysfunction-linking-obesity-and-asthma
#2
Naveen K Bhatraju, Anurag Agrawal
The bidirectional epidemiological association between asthma and obesity is well known. Recent evidence suggests that there is an intersection of the pathophysiological molecular pathways leading to either obesity or asthma, at the level of mitochondria. This is not surprising, because mitochondria, beyond their roles as the metabolic powerhouses of the cell, serve as sensors of threats, regulators of stress signaling, and effectors of cytotoxicity. Reduced mitochondrial function and low metabolic activity are well-recognized features of obesity...
November 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29160203/molecular-epidemiology-and-antimicrobial-susceptibility-of-clostridium-difficile-isolated-from-hospitals-during-a-4-year-period-in-china
#3
Yun-Bo Chen, Si-Lan Gu, Ping Shen, Tao Lv, Yun-Hui Fang, Ling-Ling Tang, Lan-Juan Li
OBJECTIVE: The aim of this study was to perform molecular characterization for and determine the antimicrobial susceptibility profiles of Clostridium difficile collected from hospitals during a 4-year period (2009-2013) in China. METHODS: Strains of toxigenic C. difficile were isolated from patients with diarrhoea, and this was followed by typing using multilocus sequence typing (MLST) and testing for susceptibility to 10 antimicrobials by using the E-test. The mechanisms of resistance to moxifloxacin, erythromycin, clindamycin and tetracycline were investigated by PCR...
November 21, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29159244/clinical-pathological-and-molecular-data-concerning-coenurus-cerebralis-in-sheep-in-egypt
#4
Said Amer, Ahmed ElKhatam, Yasuhiro Fukuda, Lamia I Bakr, Shereif Zidan, Ahmed Elsify, Mostafa A Mohamed, Chika Tada, Yutaka Nakai
This article contains information related to a recent study "Prevalence and Identity of Taenia multiceps cysts "Coenurus cerebralis" in Sheep in Egypt" (Amer et al., 2017) [1]. Specifically, affected sheep showed neurological disorders manifested as depression, head shaking and circling, altered head position, incoordination and paralysis in some cases. Brain-derived cysts were molecularly identified by PCR-sequence analysis at mitochondrial 12S rRNA gene marker. Cyst-induced pathological changes included degenerative changes and demyelination in brain tissue, infiltration of lymphocytes and histiocytes...
February 2018: Data in Brief
https://www.readbyqxmd.com/read/29157596/molecular-epidemiology-and-phylogenetic-analysis-of-human-papillomavirus-infection-in-women-with-cervical-lesions-and-cancer-from-the-coastal-region-of-ecuador
#5
Cesar H Bedoya-Pilozo, Lex G Medina Magües, Maylen Espinosa-García, Martha Sánchez, Johanna V Parrales Valdiviezo, Denisse Molina, María A Ibarra, María Quimis-Ponce, Karool España, Karla E Párraga Macias, Nancy V Cajas Flores, Solon A Orlando, Jorge A Robalino Penaherrera, Peter Chedraui, Saul Escobar, Rita D Loja Chango, Cecibel Ramirez-Morán, Jasson Espinoza-Caicedo, Sunny Sánchez-Giler, Celia M Limia, Yoan Alemán, Yudira Soto, Vivian Kouri, Andrés C A Culasso, Inés Badano
The aim of the present study was to gather information regarding the molecular epidemiology of Human papillomavirus (HPV) and related risk factors in a group of women with low- and high-grade cervical lesions and cancer from the coastal region of Ecuador. In addition, we studied the evolution of HPV variants from the most prevalent types and provided a temporal framework for their emergence, which may help to trace the source of dissemination within the region. We analyzed 166 samples, including 57 CIN1, 95 CIN2/3 and 14 cancer cases...
November 17, 2017: Revista Argentina de Microbiología
https://www.readbyqxmd.com/read/29157211/alkaline-peptone-water-enrichment-with-a-dipstick-test-to-quickly-detect-and-monitor-cholera-outbreaks
#6
Godfrey Bwire, Christopher Garimoi Orach, Dauda Abdallah, Amanda Kay Debes, Atek Kagirita, Malathi Ram, David A Sack
BACKGROUND: Detection, confirmation and monitoring of cholera outbreaks in many developing countries including Uganda is a big challenge due to lack of the required resources and the time the test takes. Culture method which takes 24-48 h to get the feedback and requires highly skilled laboratory staff plus other complex resources is the standard test. This study evaluated the new cholera rapid detection method that relies on Crystal VC dipsticks after enrichment with alkaline peptone water (APW) against the culture method for monitoring the progress of cholera outbreaks in rural setting...
November 21, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29156511/molecular-epidemiology-and-prevalence-of-echovirus-30-in-zhejiang-province-china-from-2002-to-2015
#7
Yin Chen, Yi Sun, Juying Yan, Ziping Miao, Changping Xu, Yanjun Zhang, Haiyan Mao, Liming Gong
Echovirus 30 serotype (ECHO30) has been responsible for several, recent, worldwide outbreaks of viral meningitis. In Zhejiang Province, China, ECHO30 has been one of the main causes of viral meningitis for years. This study, using phylogenetic analysis on VP1 gene, was performed to investigate the general molecular epidemiology and genetic patterns of ECHO30 circulating in Zhejiang Province between the years 2002 and 2015. The nucleotide sequences of ECHO30 VP1 showed that they were 64.8% identical with the prototype strain, Bastianni, while the amino acids were 84...
November 21, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29155863/molecular-detection-of-tick-borne-pathogens-in-cattle-from-southwestern-ethiopia
#8
Zerihun Hailemariam, Jürgen Krücken, Maximilian Baumann, Jabbar S Ahmed, Peter-Henning Clausen, Ard M Nijhof
Tick-borne diseases (TBDs) cause significant losses among livestock and impact the livelihoods of resource-poor farming communities worldwide. In Ethiopia, detailed studies on the epidemiology of tick-borne pathogens (TBPs) in cattle using sensitive molecular detection methods are scarce. The objective of this study was to determine the prevalence and species composition of bovine TBPs of veterinary significance in local cattle populations. A comprehensive cross-sectional epidemiological study was conducted in cattle populations of Illubabor zone in Southwestern Ethiopia from June to August 2013...
2017: PloS One
https://www.readbyqxmd.com/read/29155800/nicotinic-receptors-mediate-stress-nicotine-detrimental-interplay-via-dopamine-cells-activity
#9
C Morel, S P Fernandez, F Pantouli, F J Meye, F Marti, S Tolu, S Parnaudeau, H Marie, F Tronche, U Maskos, M Moretti, C Gotti, M-H Han, A Bailey, M Mameli, J Barik, P Faure
Epidemiological studies report strong association between mood disorders and tobacco addiction. This high comorbidity requires adequate treatment but the underlying mechanisms are unknown. We demonstrate that nicotine exposure, independent of drug withdrawal effects, increases stress sensitivity, a major risk factor in mood disorders. Nicotine and stress concur to induce long-lasting cellular adaptations within the dopamine (DA) system. This interplay is underpinned by marked remodeling of nicotinic systems, causing increased ventral tegmental area (VTA) DA neurons' activity and stress-related behaviors, such as social aversion...
July 25, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/29154843/clinical-isolates-of-escherichia-coli-solely-resistant-to-mecillinam-prevalence-and-epidemiology
#10
Aurore Bousquet, Sarah Bugier, Sébastien Larréché, Christine Bigaillon, Philippe Weber, Hervé Delacour, Eric Valade, Dominique De Briel, Audrey Mérens
OBJECTIVES: We observed a particular resistance phenotype: an E. coli isolate from urine sample exhibited resistance to mecillinam (Amd) but was fully susceptible to other β-lactam antibiotics (Amd-R-BL-S). Our objectives were to determine the prevalence of this phenotype and to describe their phenotype, molecular epidemiology and genetic background. METHODS: Between the 1st Jan 2014 and the 31st Jan 2016, Amd-R-BL-S E. coli isolates from urine were collected. We analysed genes previously reported as mostly involved in Amd resistance...
November 14, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29153781/genetic-epidemiology-of-autosomal-recessive-hypercholesterolemia-in-sicily-identification-by-next-generation-sequencing-of-a-new-kindred
#11
Rossella Spina, Davide Noto, Carlo M Barbagallo, Roberto Monastero, Valeria Ingrassia, Vincenza Valenti, Roberta Baschi, Antonina Pipitone, Antonina Giammanco, Maria P La Spada, Gabriella Misiano, Chiara Scrimali, Angelo B Cefalù, Maurizio R Averna
BACKGROUND: Autosomal recessive hypercholesterolemia (ARH) is a rare inherited lipid disorder. In Sardinia, differently from other world regions, the mutated allele frequency is high. It is caused by mutations in the low-density lipoprotein receptor adaptor protein 1 gene. Fourteen different mutations have been reported so far; in Sardinia, 2 alleles (ARH1 and ARH2) explain most of the cases. Four ARH patients, all carriers of the ARH1 mutation, have been identified in mainland Italy and 2 in Sicily...
October 27, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29152229/ticking-time-bombs-connections-between-circadian-clocks-and-cancer
#12
REVIEW
Katja A Lamia
Connections between mammalian circadian and cell division cycles have been postulated since the early 20th century, and epidemiological and genetic studies have linked disruption of circadian clock function to increased risk of several types of cancer. In the past decade, it has become clear that circadian clock components influence cell growth and transformation in a cell-autonomous manner. Furthermore, several molecular mechanistic connections have been described in which clock proteins participate in sensing DNA damage, modulating DNA repair, and influencing the ubiquitination and degradation of key players in oncogenesis (c-MYC) and tumor suppression (p53)...
2017: F1000Research
https://www.readbyqxmd.com/read/29151781/molecular-epidemiology-of-extended-spectrum-%C3%AE-lactamase-producing-escherichia-coli-pathotypes-in-diarrheal-children-from-low-socioeconomic-status-communities-in-bihar-india-emergence-of-the-ctx-m-type
#13
Abhishek Mandal, Abhishek Sengupta, Ajay Kumar, Utpal K Singh, Anil K Jaiswal, Pradeep Das, Sushmita Das
Background: Childhood diarrheal diseases remain highly endemic in India, but the emergence of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli among children with diarrhea in Bihar remains elusive. In this study, we determine and characterize ESBL-producing E coli pathotypes among hospitalized diarrheal preschool children living in low socioeconomic level communities in Bihar, India. Materials and methods: The stool samples were collected everyday throughout the year for 2 consecutive years...
2017: Infectious Diseases
https://www.readbyqxmd.com/read/29150913/molecular-epidemiology-of-goat-pox-viruses
#14
P Roy, S Jaisree, S Balakrishnan, K Senthilkumar, R Mahaprabhu, A Mishra, B Maity, T K Ghosh, A P Karmakar
Goat pox disease outbreaks were observed in different places affecting Black Bengal Goats in West Bengal (WB) and Tellicherry, Vembur and non-descriptive breeds in Tamil Nadu (TN) causing severe lesions and mortality up to 30%. Clinical specimens from all the outbreaks were screened by polymerase chain reaction followed by restriction fragment length polymorphism (PCR-RFLP) and confirmed the diseases as Goat Pox. Virus isolation in Vero cell line was done with randomly selected ten samples, cytopathic effects (CPE) characterized by syncytia and intracytoplasmic inclusion bodies were observed after several blind passages...
November 18, 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29150903/phylogenetic-and-genetic-variation-analyses-of-porcine-circovirus-type-2-isolated-from-china
#15
S Yang, S Yin, Y Shang, B Liu, L Yuan, M U Zafar Khan, X Liu, J Cai
Porcine circovirus type 2 (PCV2) is a causative agent of PCV2-associated disease, which is a growing problem in the swine industry worldwide. High nucleotide substitution occurs in the capsid (Cap) gene of PCV2, which allows the continuous evolution and the emergence of novel PCV2 strains. In this study, we sequenced 24 Chinese PCV2 strains collected from healthy and diseased pigs between 2013 and 2015. Analyses of the genome, Cap and phylogeny classified the 24 Chinese PCV2 strains as PCV-2a (four of 24), PCV-2b (five of 24) and PCV-2d (15 of 24)...
November 17, 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29150273/recurrent-and-disseminated-pityriasis-versicolor-a-novel-clinical-form-consequent-to-malassezia-host-interaction
#16
Karina Romero-Sandoval, Anderson Alves Costa, Maria Glória Teixeira Sousa, Celia Regina Furucho, Neusa Valente, Paulo R Criado, Valeria Aoki, Gil Benard
Pityriasis versicolor is a superficial fungal infection caused by Malassezia spp. The aim of this study is to propose the definition of a new clinical entity: the recurrent and disseminated pityriasis versicolor (RDPV). All patients with RDPV were enrolled over an eight-month period. Clinical and epidemiological data were obtained, Malassezia (M.) species were isolated in cultures and identified by phenotypic and molecular characterization, skin biopsies were taken from active lesions, serum levels of immunoglobulin E were obtained and therapeutic schemes were evaluated...
November 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/29149898/detection-of-plasmodium-falciparum-male-and-female-gametocytes-and-determination-of-parasite-sex-ratio-in-human-endemic-populations-by-novel-cheap-and-robust-rtqpcr-assays
#17
Federica Santolamazza, Pamela Avellino, Giulia Siciliano, Franck Adama Yao, Fabrizio Lombardo, Jean Bosco Ouédraogo, David Modiano, Pietro Alano, Valentina Dianora Mangano
BACKGROUND: The presence of Plasmodium falciparum gametocytes in peripheral blood is essential for human to mosquito parasite transmission. The detection of submicroscopic infections with gametocytes and the estimation of the gametocyte sex ratio are crucial to assess the human host potential ability to infect mosquitoes and transmit malaria parasites. AIM AND OBJECTIVES: The aim of this work was to develop sensitive and cheap Real Time qPCR assays for large-scale epidemiological surveys, based on detection and amplification of gametocyte sex specific transcripts selected from the literature: the female-specific pfs25 and pf glycerol kinase (pfGK) and the male-specific pfs230p and pf13 transcripts...
November 17, 2017: Malaria Journal
https://www.readbyqxmd.com/read/29148521/author-s-correction-molecular-epidemiology-and-antimicrobial-susceptibility-of-ampc-and-or-extended-spectrum-esbl-%C3%A3-lactamaseproducing-proteus-spp-clinical-isolates-in-zenica-doboj-canton-bosnia-and-herzegovina
#18
Selma Uzunović, Amir Ibrahimagić, Branka Bedenić
Volume 13, no. 2, p. 103-112, 2016. Page 103: The byline should appear as shown above.
August 2017: Medicinski Glasnik
https://www.readbyqxmd.com/read/29147866/a-review-of-onychomycosis-due-to-aspergillus-species
#19
REVIEW
Felix Bongomin, C R Batac, Malcolm D Richardson, David W Denning
Aspergillus spp. are emerging causative agents of non-dermatophyte mould onychomycosis (NDMO). New Aspergillus spp. have recently been described to cause nail infections. The following criteria are required to diagnose onychomycosis due to Aspergillus spp.: (1) positive direct microscopy and (2) repeated culture or molecular detection of Aspergillus spp., provided no dermatophyte was isolated. A review of 42 epidemiological studies showed that onychomycosis due to Aspergillus spp. varies between < 1 and 35% of all cases of onychomycosis in the general population and higher among diabetic populations accounting for up to 71% and the elderly; it is very uncommon among children and adolescence...
November 16, 2017: Mycopathologia
https://www.readbyqxmd.com/read/29147722/-dengue-fever-symptoms-epidemiology-entomology-pathogen-diagnosis-and-prevention
#20
D Wiemer, H Frickmann, A Krüger
Dengue infections are among the most frequent causes of febrile disease in tropical climates. Infections are caused by a flavivirus transmitted by the Aedes mosquito. Aedes aegypti mosquitos are the main transmitters of Dengue viruses. Since these insects are both diurnal and container breeders, particular prevention and control measures are required. Symptom severity varies and can range from a mild, flu-like clinical picture to severe hemorrhage and shock. The most common symptoms experienced by travelers include fever, muscular pain, headaches and skin rash...
November 16, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
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