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https://www.readbyqxmd.com/read/27905281/identification-of-acanthamoeba-genotypes-in-pools-and-stagnant-water-in-ponds-in-sistan-region-in-southeast-iran
#1
Ali Aghajani, Mansour Dabirzadeh, Yahya Maroufi, Hossein Hooshyar
OBJECTIVE: Acanthamoeba is one of the most abundant free-living amoebas that is widely distributed in natural and artificial environment resources. Acanthamoeba pathogenic genotypes cause chronic human diseases including amoebic keratitis and granulomatous amoebic encephalitis. The aim of this study was to determine and identify Acanthamoeba genotypes residing in pools and stagnant water in ponds in Sistan region in southeast Iran. This descriptive study was conducted at the Parasitology Laboratory, School of Medicine, Zabol University of Medical Sciences...
September 2016: Türkiye Parazitolojii Dergisi
https://www.readbyqxmd.com/read/27876286/clinical-trials-in-a-dish
#2
David G Strauss, Ksenia Blinova
Clinical trials 'in a dish' involve testing medical therapies for safety or effectiveness in the laboratory with human tissue. This has become possible owing to recent biotechnology advances including induced pluripotent stem cells, organs-on-a-chip, and whole-genome sequencing. We provide here an overview of the landscape and highlight steps the FDA is taking to advance the science of clinical trials in a dish and to support the development and validation of new regulatory paradigms to assess drug safety using these new technologies...
November 19, 2016: Trends in Pharmacological Sciences
https://www.readbyqxmd.com/read/27872781/two-invasive-thymomas-incidentally-found-during-coronary-artery-bypass-graft-surgery
#3
Navid Omidifar, Maral Mokhtari, Mansoureh Shokripour
Thymoma, the most common neoplasm of the anterior mediastinum, is a rare tumor of thymic epithelium that can be locally invasive. We reported 2 cases of invasive thymoma incidentally found during routine coronary artery bypass graft (CABG) surgery at Faghihee Hospital of Shiraz University of Medical Sciences of Iran in a period of about 6 months. The 2 patients were male and above 60 years old. They had no clinical symptoms and radiological evidence of mediastinal mass before detection of the tumor during operation...
2016: Case Reports in Pathology
https://www.readbyqxmd.com/read/27871504/efficacy-and-safety-of-sugammadex-compared-to-neostigmine-for-reversal-of-neuromuscular-blockade-a-meta-analysis-of-randomized-controlled-trials
#4
REVIEW
Michele Carron, Francesco Zarantonello, Paola Tellaroli, Carlo Ori
BACKGROUND AND OBJECTIVE: Sugammadex has been introduced for reversal of rocuronium (or vecuronium)-induced neuromuscular blockade (NMB). Although its efficacy has been established, data are conflicting whether it is safer than neostigmine traditionally used for reversing NMB. DESIGN: Meta-analysis of data about effectiveness and safety of sugammadex compared to neostigmine for reversing NMB in adults was performed using the PRISMA methodology. SETTING: University medical hospital...
December 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27866899/potential-of-compact-compton-sources-in-the-medical-field
#5
Marie Jacquet
The exceptional improvement of high power lasers and optical cavity finesses in the last fifteen years allows today the development of X-ray sources based on inverse Compton scattering. These compact sources will provide high intensity beams, with a tunable energy in the range 20-100keV, that can be used in several application including material sciences, structural biology, cultural heritage research and preservation and medical or biomedical preclinical and clinical research. The access to these devices will be easier...
November 17, 2016: Physica Medica: PM
https://www.readbyqxmd.com/read/27858891/pediatric-visceral-leishmaniasis-in-northwest-of-iran
#6
Babak Abdinia, Mohammad Oliaei-Motlagh, Amir Teimouri-Dereshki
Leishmaniasis is one of the major health problems in Iran. Although the incidence of visceral leishmaniasis (VL) is reported almost everywhere, the northwestern Iran is one of the major endemic regions.To do this study, clinical, laboratory as well as disease characteristics of children admitted to Children Cure and Health Hospital, Tabriz University of Medical Sciences, were examined as the reference hospital for the treatment of VL in northwestern Iran.In this study, 156 children hospitalized in a pediatric hospital from 2000 to 2015 for VL were included...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27833652/molecular-detection-of-epstein-barr-virus-in-nasopharyngeal-carcinoma-among-sudanese-population
#7
Ali Edreis, Mona Ali Mohamed, Nouh S Mohamed, Emmanuel E Siddig
BACKGROUND: Nasopharyngeal carcinoma (NPC) is the most common cancer arising from the nasopharynx that varies significantly from other cancers of the head and neck in its occurrence, causes, clinical behavior, and treatment. NPC caused by an interaction between infection with EBV and environmental and genetic factors, encompasses a multistep oncogenic process. The frequency of Epstein-Barr virus EBV among nasopharyngeal carcinoma is well known worldwide, however, in the Sudan there is barely a published data...
2016: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/27833244/nigeria-s-national-health-act-an-assessment-of-health-professionals-knowledge-and-perception
#8
Osahon Enabulele, Joan Emien Enabulele
BACKGROUND: Nigeria's National Health Act 2014 (NHA 2014) was signed into law on October 31, 2014. It provides a legal framework for the regulation, development, and management of Nigeria's Health System. This study assessed the knowledge and perception of the NHA 2014 by health professionals. MATERIALS AND METHODS: This was a descriptive, cross-sectional, questionnaire-based study conducted in December 2015, in Ota, Ogun State, Nigeria. Data entry and analysis were done using the Statistical Package for the Social Sciences version 16 (IBM SPSS, Chicago, IL, USA) statistical software, with Pearson's Chi-square, which is used to determine the associations between variables...
September 2016: Nigerian Medical Journal: Journal of the Nigeria Medical Association
https://www.readbyqxmd.com/read/27829809/bridging-theory-and-practice-mixed-methods-approach-to-instruction-of-law-and-ethics-within-the-pharmaceutical-sciences
#9
Kyle John Wilby, Ziad Ghantous Nasr
Background: Professional responsibilities are guided by laws and ethics that must be introduced and mastered within pharmaceutical sciences training. Instructional design to teaching typically introduces concepts in a traditional didactic approach and requires student memorization prior to application within practice settings. Additionally, many centers rely on best practices from abroad, due to lack of locally published laws and guidance documents. Objectives: The aim of this paper was to summarize and critically evaluate a professional skills laboratory designed to enhance learning through diversity in instructional methods relating to pharmacy law and best practices regarding narcotics, controlled medications, and benzodiazepines...
November 2016: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/27824287/interview-with-david-j-brayden
#10
David J Brayden
David Brayden speaks to Hannah Makin, Commissioning Editor: David Brayden is a Full Professor (Advanced Drug Delivery) at the School of Veterinary Medicine, University College Dublin (UCD) and also a Fellow of the UCD Conway Institute. Following a PhD in Pharmacology at the University of Cambridge, UK (1989), and a postdoctoral research fellowship at Stanford University, CA, USA, he set up Elan Biotechnology Research's in vitro pharmacology laboratory in Dublin (1991). At Elan, he became a senior scientist and project manager of several of Elan's joint-venture drug delivery research collaborations with US biotech companies...
November 8, 2016: Therapeutic Delivery
https://www.readbyqxmd.com/read/27807148/a-rose-by-any-other-name-practical-updates-on-microbial-nomenclature-for-clinical-microbiology
#11
EDITORIAL
Colleen S Kraft, Alexander J McAdam, Karen C Carroll
The clinical microbiology laboratory stands at the interface between basic science, including the study of phylogeny, and applications of science in the very practical world of medical care.….
November 2, 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27806847/false-positive-results-in-diagnostic-immunohistochemistry-are-related-to-horseradish-peroxidase-conjugates-in-commercially-available-assays
#12
Gerard Nuovo
False-positive results in diagnostic immunopathology can lead to unnecessary treatments. The purpose of this study was to do a side-by-side comparison of 10 different antibodies commonly used in the clinical laboratory altering only the horseradish peroxidase (HRP) conjugate. The automated Leica BOND-MAX platform was used to study serial sections from 203 tissues including controls compared in a blinded fashion using the HRP conjugates from Leica (Refine HRP), Ventana Medical Systems (Ultraview HRP), and Enzo Life Sciences (Polyview HRP)...
December 2016: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/27800290/antibiogram-of-medical-intensive-care-unit-at-tertiary-care-hospital-setting-of-pakistan
#13
Aayesha Qadeer, Aftab Akhtar, Qurat Ul Ain, Shoab Saadat, Salman Mansoor, Salman Assad, Wasib Ishtiaq, Abid Ilyas, Ali Y Khan, Yousaf Ajam
OBJECTIVE:  To determine the frequency of micro-organisms causing sepsis as well as to determine the antibiotic susceptibility and resistance of microorganisms isolated in a medical intensive care unit. MATERIALS AND METHODS:  This is a cross-sectional analysis of 802 patients from a medical intensive care unit (ICU) of Shifa International Hospital, Islamabad, Pakistan over a one-year period from August 2015 to August 2016. Specimens collected were from blood, urine, endotracheal secretions, catheter tips, tissue, pus swabs, cerebrospinal fluid, ascites, bronchoalveolar lavage (BAL), and pleural fluid...
September 29, 2016: Curēus
https://www.readbyqxmd.com/read/27795453/medical-research-in-stalin-s-gulag
#14
Golfo Alexopoulos
Recently declassified Gulag archives reveal for the first time that the Stalinist leadership established medical research laboratories in the camps. The present work offers an initial reading of the medical research conducted by and on prisoners in Stalin's Gulag. Although Gulag science did not apparently possess the lethal character of Nazi medicine, neither was this work entirely benign. I argue that the highly constrained environment of the Stalinist camps distorted medical science. Scientists were forced to produce work agreeable to their Gulag administrators...
2016: Bulletin of the History of Medicine
https://www.readbyqxmd.com/read/27792053/probiotics-mediated-suppression-of-cancer
#15
Stephanie S Y So, Murphy L Y Wan, Hani El-Nezami
PURPOSE OF REVIEW: Probiotics can be used as an adjuvant for cancer prevention or/and treatment through their abilities to modulate intestinal microbiota and host immune response. Although most of the recent reviews have focused on the potential role of probiotics against colon cancer, only few of them include the probiotic effect on extraintestinal cancers. The present review covers the most important findings from the literature published during the past 20 months (from January 2015 to August 2016) regarding the probiotics-mediated suppression of both gastrointestinal and extraintestinal cancers and the underlying mechanisms...
January 2017: Current Opinion in Oncology
https://www.readbyqxmd.com/read/27788727/-a-clinical-analysis-of-22-patients-with-drug-induced-liver-injury-caused-by-traditional-chinese-medicine-periploca-forrestii-schltr
#16
J C Feng, H Y Wang, A Q Zhou, D X Wang, Q Xie, H Jiang, G M Qian
Objective: To investigate the clinical features, diagnosis, treatment, and prognosis of patients with liver injury caused by Periploca forrestii Schltr. Methods: A retrospective analysis was performed for the general data, clinical manifestations, and laboratory examinations of 22 patients who were diagnosed with liver injury caused by Periploca forrestii Schltr. from November 2014 to December 2015, and their clinical type was determined according to the classification criteria of drug-induced liver injury recommended by the Council for International Organizations of Medical Sciences...
September 20, 2016: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/27776971/association-between-vascular-calcification-assessed-by-simple-radiography-and-non-fatal-cardiovascular-events-in-hemodialysis-patients
#17
Vaida Petrauskiene, Ruta Vaiciuniene, Inga Arune Bumblyte, Vytautas Kuzminskis, Edita Ziginskiene, Saulius Grazulis, Egle Jonaitiene
BACKGROUND: Vascular calcification (VC) is one of the factors associated with cardiovascular mortality in hemodialysis (HD) patients. Recommendations concerning screening for VC differ. Possible ability to prevent and reversibility of VC are major subjects on debate whether screening for VC could improve outcomes of renal patients. The objective of the study was to evaluate the significance of simple vascular calcification score (SVCS) based on plane radiographic films and to test its association with non-fatal cardiovascular events in patients on chronic HD...
October 21, 2016: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/27754282/hw-04-3-global-network-for-her-based-big-data-analysis
#18
Peter Rijnbeek
Massive numbers of electronic health records are currently being collected globally, including structured data in the form of diagnoses, medications, laboratory test results, and unstructured data contained in clinical narratives. This opens unprecedented possibilities for research and ultimately patient care. However, actual use of these databases in a multi-center study is severely hampered by a variety of challenges, e.g., each database has a different database structure and uses different terminology systems...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27753172/life-science-based-neuroscience-education-at-large-western-public-universities
#19
Volkan Coskun, Ellen M Carpenter
The last 40 years have seen a remarkable increase in the teaching of neuroscience at the undergraduate level. From its origins as a component of anatomy or physiology departments to its current status as an independent interdisciplinary field, neuroscience has become the chosen field of study for many undergraduate students, particularly for those interested in medical school or graduate school in neuroscience or related fields. We examined how life science-based neuroscience education is offered at large public universities in the Western United States...
December 2016: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27748302/the-making-of-indigenous-vascular-prosthesis
#20
Madathipat Unnikrishnan, Sidharth Viswanathan, K Balasubramaniam, C V Muraleedharan, Arthur Vijayan Lal, P V Mohanan, Meera Mohanty, Tirur Raman Kapilamoorthy
BACKGROUND & OBJECTIVES: Vascular illnesses are on the rise in India, due to increase in lifestyle diseases and demographic transition, requiring intervention to save life, organ or limbs using vascular prosthesis. The aim of this study was to develop indigenous large diameter vascular graft for treatment of patients with vascular pathologies. METHODS: The South India Textile Research Association, at Coimbatore, Tamil Nadu, India, developed seamless woven polyester (Polyethylene terephthalate) graft at its research wing...
June 2016: Indian Journal of Medical Research
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