Shermarke Hassan, Guido Baselli, Luca Mollica, Riccardo L Rossi, Himani Chand, Amal Mohamed El-Beshlawy, Mohsen Saleh Elalfy, Vijay Ramanan, Peyman Eshghi, Mehran Karimi, Roberta Palla, Frits R Rosendaal, Flora Peyvandi
Inhibitor development is the most severe complication of hemophilia A care, and is associated with increased morbidity and mortality. The aim of this study was to use a novel IgG epitope mapping method to explore the factor VIII (FVIII)-specific epitope profile in the SIPPET cohort population and to develop an epitope-mapping based inhibitor prediction model. The population consisted of 122 previously untreated patients with severe hemophilia A that were followed-up for 50 days of exposure to FVIII or 3 years, whichever occurred first...
April 9, 2024: Blood Advances