Xavier Santamaria, Beatriz Roson, Raul Perez-Moraga, Nandakumar Venkatesan, Maria Pardo-Figuerez, Javier Gonzalez-Fernandez, Jaime Llera-Oyola, Estefania Fernández, Inmaculada Moreno, Andres Salumets, Hugo Vankelecom, Felipe Vilella, Carlos Simon
Asherman's Syndrome is characterized by intrauterine adhesions or scarring, which cause infertility, menstrual abnormalities, and recurrent pregnancy loss. The pathophysiology of this syndrome remains unknown, with treatment restricted to recurrent surgical removal of intrauterine scarring, which has limited success. Here, we decode the Asherman's Syndrome endometrial cell niche by analyzing data from over 200,000 cells with single-cell RNA-sequencing in patients with this condition and through in vitro analyses of Asherman's Syndrome patient-derived endometrial organoids...
September 21, 2023: Nature Communications