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Asherman syndrome

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https://www.readbyqxmd.com/read/29133764/advanced-role-of-hippo-signaling-in-endometrial-fibrosis-implications-for-intrauterine-adhesion
#1
REVIEW
Hai-Yan Zhu, Tian-Xiang Ge, Yi-Bin Pan, Song-Ying Zhang
OBJECTIVE: Intrauterine adhesion (IUA) is a major health problem that causes infertility, menstrual irregularities, and recurrent pregnancy losses in women. Unfortunately, treatments for IUA are limited, and there are currently no effective strategies for preventing IUA recurrence. In this review, we introduced the role of Hippo signaling in the normal endometrium and IUA and described the mechanisms by which the Hippo pathway integrates with the Wnt and transforming growth factor-β (TGF-β) signaling pathways to form an intricate network governing the development of fibrosis...
November 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/29043704/accuracy-of-two-dimensional-transvaginal-sonography-and-office-hysteroscopy-for-detection-of-uterine-abnormalities-in-patients-with-repeated-implantation-failures-or-recurrent-pregnancy-loss
#2
Marzieh Shiva, Firouzeh Ahmadi, Arezoo Arabipoor, Mansoureh Oromiehchi, Mohammad Chehrazi
Background: We sought to compare diagnostic values of two-dimensional transvaginal sonography (2D TVS) and office hysteroscopy (OH) for evaluation of endometrial pathologies in cases with repeated implantation failure (RIF) or recurrent pregnancy loss (RPL). MATERIALS AND METHODS: This prospective study was performed at Royan Institute from December 2013 to January 2015. TVS was performed before hysteroscopy as part of the routine diagnostic work-up in 789 patients with RIF or RPL...
January 2018: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/29024798/hysteroscopic-management-of-asherman-s-syndrome-special-issue-report-on-uterine-surgery-in-the-journal-of-minimally-invasive-gynecology
#3
Zaraq Khan, Jeffrey M Goldberg
In developed countries, Asherman's Syndrome is almost always the result of a prior intrauterine operative trauma. This is often asymptomatic but may result in hypo- or amenorrhea and can contribute to infertility and pregnancy complications. We will review their etiology, clinical implications, and the systems which have been proposed to classify their extent. The numerous methods reported for performing lysis of intrauterine adhesions will be summarized along with the clinical results. Current strategies to prevent recurrence of intrauterine adhesions have not been conclusively shown to be clinically effective but the potential for endometrial regeneration using stem cells is an exciting modality under investigation...
October 9, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28939480/hysteroscopic-removal-of-retained-products-of-conception-implanted-over-a-focal-area-of-adenomyosis-a-case-report
#4
Luis Alonso, Laura Nieto, Jose Carugno
STUDY OBJECTIVE: To describe a technique for hysteroscopic removal of retained products of conception (RPOC) implanted over an area of adenomyosis. DESIGN: A case report (Canadian Task Force classification III). SETTING: RPOC is an unfortunate complication that may occur after the resolution of a normal pregnancy; it is more common after early pregnancy termination or spontaneous miscarriage [1]. Immediate consequences of RPOC include persistent vaginal bleeding, abdominal pain, pelvic infection, fever, and dilated cervix...
September 20, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28913973/bone-marrow-stem-cells-do-not-contribute-to-endometrial-cell-lineages-in-chimeric-mouse-models
#5
Yih Rue Ong, Fiona L Cousins, Xiaoqing Yang, Ahmed Aedh A Al Mushafi, David T Breault, Caroline E Gargett, James A Deane
Studies from five independent laboratories conclude that bone marrow stem cells transdifferentiate into endometrial stroma, epithelium, and endothelium. We investigated the nature of bone marrow-derived cells in the mouse endometrium by reconstituting irradiated wild type recipients with bone marrow containing transgenic mTert-green fluorescent protein (GFP) or chicken β-actin (Ch β-actin)-GFP reporters. mTert-GFP is a telomerase marker identifying hematopoietic stem cells and subpopulations of epithelial, endothelial, and immune cells in the endometrium...
September 15, 2017: Stem Cells
https://www.readbyqxmd.com/read/28782281/systemic-administration-of-bone-marrow-derived-cells-leads-to-better-uterine-engraftment-than-use-of-uterine-derived-cells-or-local-injection
#6
Ying Liu, Reshef Tal, Nicola Pluchino, Ramanaiah Mamillapalli, Hugh S Taylor
Stem cells are recruited to the uterus where they differentiate into endometrial cells and have been suggested as potential therapy for uterine injury such as Asherman's syndrome. However, it is unknown whether local intrauterine injection may result in better stem cell engraftment of the uterus compared with systemic administration, and whether uterine-derived cells (UDCs) may confer an advantage over BM-derived cells (BMDCs). Mice underwent local injury to a single uterine horn. Green fluorescent protein (GFP)-expressing BMDCs, UDCs or saline (control) were injected either intravenously or locally (uterine lumen) into wild-type recipients...
August 7, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28647784/replacing-single-frozen-thawed-euploid-embryos-in-a-natural-cycle-in-ovulatory-women-may-increase-live-birth-rates-compared-to-medicated-cycles-in-anovulatory-women
#7
Alexis P Melnick, Robert Setton, Logan D Stone, Nigel Pereira, Kangpu Xu, Zev Rosenwaks, Steven D Spandorfer
PURPOSE: The goal of this study was to compare pregnancy outcomes between natural frozen embryo transfer (FET) cycles in ovulatory women and programmed FET cycles in anovulatory women after undergoing in vitro fertilization with preimplantation genetic screening (IVF-PGS). METHODS: This was a retrospective cohort study performed at an academic medical center. Patients undergoing single FET IVF-PGS cycles between October 2011 and December 2014 were included. Patients were stratified by type of endometrial replacement: programmed cycles with estrogen/progesterone replacement and natural cycles...
October 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28582327/a-comprehensive-review-of-asherman-s-syndrome-causes-symptoms-and-treatment-options
#8
Christina A Salazar, Keith Isaacson, Stephanie Morris
PURPOSE OF REVIEW: Intrauterine adhesions, also known as Asherman's syndrome, can have an impact on both reproductive outcomes and gynaecologic symptoms. Understanding the cause of intrauterine adhesions and the common clinical presentation will increase awareness of the condition and guide the patient to appropriate therapy. Surgical management offers favourable fertility outcomes and is often successful in restoring menstruation. RECENT FINDINGS: Surgical management with hysteroscopic lysis of adhesions is the gold standard for treatment and adopting an office-based approach offers several advantages...
August 2017: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28461178/four-surgical-approaches-to-cervical-excision-during-laparoscopic-radical-trachelectomy-for-early-cervical-cancer
#9
José Saadi, Lucas Minig, Florencia Noll, Gabriel Saraniti, José Miguel Cárdenas-Rebollo, Myriam Perrotta
STUDY OBJECTIVE: To compare the clinical and oncological outcomes of four different approaches of cervical excision (CE) during radical trachelectomy (RT) for early cervical cancer. DESIGN: A retrospective comparative observational study was performed at Gynecology Department of the Hospital Italiano de Buenos Aires in Buenos Aires, Argentine. The study was composed of all consecutive women who had undergone laparoscopic RT for early cervical cancer between May 2011 and July 2016...
April 28, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28400095/anti-mullerian-hormone-as-a-parameter-for-endometrial-trauma-in-asherman-syndrome-a-retrospective-data-analysis
#10
Regina Promberger, Johannes Ott
Recently, the endometrium has been identified as a repository for Anti-Mullerian hormone (AMH), with endometrial masses associated with AMH serum levels. We aimed to compare AMH levels, as well as other parameters for ovarian reserve, in women with endometrial trauma due to Asherman syndrome (AS) and matched controls. In a retrospective study, nine women with hysteroscopically confirmed AS were compared to nine matched controls. Follicle-stimulating hormone, luteinizing hormone, and estradiol levels did not differ between women with and without AS, whereas significantly lower AMH levels were found in patients (median 0...
April 8, 2017: Reproductive Biology
https://www.readbyqxmd.com/read/28389908/validation-of-rem-score-to-predict-endometrial-cancer-in-patients-with-ultrasound-endometrial-abnormalities-results-of-a-new-independent-dataset
#11
Francesco Plotti, Stella Capriglione, Corrado Terranova, Roberto Montera, Giuseppe Scaletta, Salvatore Lopez, Daniela Luvero, Antonelli Gianina, Alessia Aloisi, Pierluigi Benedetti Panici, Roberto Angioli
The risk of endometrial malignancy (REM) score is a model formulated in a previous single-center validation study, which has been shown to predict endometrial cancer in women with ultrasound endometrial abnormalities based on multiple features (clinical, ultrasound and laboratorial). The purpose of this study was to validate the performance of REM score in an external validation setting. A population-based database with patients, who underwent elective hysteroscopy for ultrasound endometrial abnormalities between 2013 and 2016 at Department of Obstetrics and Gynecology of Campus Bio-medico of Rome, was used...
May 2017: Medical Oncology
https://www.readbyqxmd.com/read/28345002/cxcl12-promotes-stem-cell-recruitment-and-uterine-repair-after-injury-in-asherman-s-syndrome
#12
Gulcin Sahin Ersoy, Masoumeh Majidi Zolbin, Emine Cosar, Irene Moridi, Ramanaiah Mamillapalli, Hugh S Taylor
Asherman's syndrome is an acquired condition of uterine fibrosis and adhesions in response to injury that adversely affects fertility and pregnancy. We have previously demonstrated that bone marrow-derived mesenchymal stem cells (BMDSCs) contribute to uterine repair after injury and that stem cells supplementation improves fertility. Here, we demonstrate that CXCL12 is the chemokine that mediates stem cell engraftment and functional improvement using a murine model of Asherman's syndrome. After uterine injury, we demonstrate that CXCL12 augmentation increased BMDSC engraftment and that the CXCL12 receptor (CXCR4) antagonist, ADM3100, blocked stem cell recruitment...
March 17, 2017: Molecular Therapy. Methods & Clinical Development
https://www.readbyqxmd.com/read/28148903/elevated-nf-%C3%AE%C2%BAb-signaling-in-asherman-syndrome-patients-and-animal-models
#13
Xiangzhen Wang, Nana Ma, Qiannan Sun, Chenlingzi Huang, Yanmei Liu, Xin Luo
Asherman syndrome (intrauterine adhesion) is often associated with menstrual abnormalities, infertility and recurrent miscarriage in female. Currently the molecular mechanism regulating the pathogenesis of Asherman syndrome is not known. Here we revealed that the inflammatory factor NF-κB expression is significantly elevated in the endometrial samples of Asherman syndrome patients. To further study the molecular mechanisms, we established an Asherman syndrome rat model and confirmed the important role of NF-κB in the pathogenesis of Asherman syndrome...
February 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28059844/gynecologic-surgery-preoperative-assessment-with-ultrasound
#14
Laurel Stadtmauer, Akhil Shah
Ultrasonography, especially 3D, is essential in the diagnosis and preoperative evaluation of gynecologic surgeries and is important in surgical planning and counseling of patients. In addition, it is useful during hysteroscopic procedures, particularly difficult Asherman syndrome cases, resection of transverse vaginal septum, and treatment of hematometria. 3D ultrasound is especially helpful for fibroid mapping as the simultaneous visualization of the endometrium and myometrium with the coronal view is possible, it can be done by the gynecologist and at a lower cost than an magnetic resonance imaging...
March 2017: Clinical Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27921235/transplantation-of-collagen-scaffold-with-autologous-bone-marrow-mononuclear-cells-promotes-functional-endometrium-reconstruction-via-downregulating-%C3%AE-np63-expression-in-asherman-s-syndrome
#15
Guangfeng Zhao, Yun Cao, Xianghong Zhu, Xiaoqiu Tang, Lijun Ding, Haixiang Sun, Juan Li, Xinan Li, Chenyan Dai, Tong Ru, Hui Zhu, Jingjie Lu, Caimei Lin, Jingmei Wang, Guijun Yan, Huiyan Wang, Lei Wang, Yimin Dai, Bin Wang, Ruotian Li, Jianwu Dai, Yan Zhou, Yali Hu
Asherman's syndrome (AS) is a common disease that presents endometrial regeneration disorder. However, little is known about its molecular features of this aregenerative endometrium in AS and how to reconstruct the functioning endometrium for the patients with AS. Here, we report that ΔNp63 is significantly upregulated in residual epithelial cells of the impaired endometrium in AS; the upregulated-ΔNp63 induces endometrial quiescence and alteration of stemness. Importantly, we demonstrate that engrafting high density of autologous bone marrow mononuclear cells (BMNCs) loaded in collagen scaffold onto the uterine lining of patients with AS downregulates ΔNp63 expression, reverses ΔNp63-induced pathological changes, normalizes the stemness alterations and restores endometrial regeneration...
April 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/27856386/reproductive-outcomes-in-patients-with-intrauterine-adhesions-following-hysteroscopic-adhesiolysis-experience-from-the-largest-women-s-hospital-in-china
#16
Limei Chen, Hongwei Zhang, Qing Wang, Feng Xie, Shujun Gao, Yu Song, Jing Dong, Hua Feng, Kangyun Xie, Long Sui
STUDY OBJECTIVE: To analyze the reproductive outcome of hysteroscopic adhesiolysis and assess the diagnostic accuracy of transvaginal ultrasonography (TVS) in infertile women resulting from intrauterine adhesions (IUAs). DESIGN: Retrospective, cross-sectional study (Canadian Task Force classification II-2). SETTING: University tertiary referral center. PATIENTS: Three hundred and fifty-seven patients with mild, moderate, and severe IUAs who underwent hysteroscopic adhesiolysis between January 2012 and December 2015...
February 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27678984/reproductive-outcome-of-patients-with-asherman-s-syndrome-after-hysteroscopic-adhesiolysis
#17
B Dilbaz, F Akpinar, S Altinbas, S Yilmaz, R Ozelci, S Dilbaz
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27678648/treatment-of-asherman-s-syndrome-in-an-outpatient-hysteroscopy-setting
#18
O Bougie, K Lortie, I Chen, H Shenassa, S S Singh
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27670361/high-molecular-weight-hyaluronic-acid-inhibits-fibrosis-of-endometrium
#19
Yi Zhu, Jianguo Hu, Tinghe Yu, Yan Ren, Lina Hu
BACKGROUND Elevated fibrosis has been found in patients with intrauterine adhesion, which indicates that fibrotic factors may play a critical role in formation of intrauterine adhesion. The aim of this study was to identify the effect of hyaluronic acid (HA) at high and low molecular weight on fibrosis of the endometrium in a mouse model of Asherman's syndrome. MATERIAL AND METHODS Endometrial fibrosis in a mouse model of Asherman's syndrome was confirmed. Then HA at high and low molecular weight was injected into the uterine cavity...
September 27, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27664218/autologous-menstrual-blood-derived-stromal-cells-transplantation-for-severe-asherman-s-syndrome
#20
Jichun Tan, Pingping Li, Qiushi Wang, Yaxuan Li, Xiaoni Li, Dongni Zhao, Xiaoyan Xu, Lin Kong
STUDY QUESTION: Does autologous transplantation of menstrual blood-derived stromal cells (menSCs) regenerate endometrium to support pregnancy in patients with severe Asherman's syndrome (AS)? SUMMARY ANSWER: Autologous menSCs transplantation significantly increases endometrial thickness (ET) for women with severe AS. WHAT IS KNOWN ALREADY: AS is a major cause of secondary infertility in women. Cell transplantation has been tried in a few clinical cases with encouraging results...
September 22, 2016: Human Reproduction
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