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https://www.readbyqxmd.com/read/29597272/a-potential-adjuvant-agent-of-chemotherapy-sepia-ink-polysaccharides
#1
REVIEW
Fangping Li, Ping Luo, Huazhong Liu
Sepia ink polysaccharide (SIP) isolated from squid and cuttlefish ink is a kind of acid mucopolysaccharide that has been identified in three types of primary structures from squid ( Illex argentinus and Ommastrephes bartrami ), cuttlefish Sepiella maindroni, and cuttlefish Sepia esculenta ink. Although SIP has been proved to be multifaceted, most of the reported evidence has illuminated its chemopreventive and antineoplastic activities. As a natural product playing a role in cancer treatment, SIP may be used as chemotherapeutic ancillary agent or functional food...
March 28, 2018: Marine Drugs
https://www.readbyqxmd.com/read/29550586/unraveling-the-interplay-between-senescent-dermal-fibroblasts-and-cutaneous-squamous-cell-carcinoma-cell-lines-at-different-stages-of-tumorigenesis
#2
Marie Toutfaire, Elise Dumortier, Antoine Fattaccioli, Martine Van Steenbrugge, Charlotte M Proby, Florence Debacq-Chainiaux
Cutaneous Squamous Cell Carcinoma (cSCC) is the second most common type of non-melanoma skin cancer in white-skinned populations. cSCC is associated with sun exposure and aging, which is concomitant with an accumulation of senescent cells in the skin. The involvement of senescent cells in carcinogenesis has been highlighted in several cancer types and an interaction between cSCC cells and senescent cells is proposed, but still little explored. Tumor-associated effects are mostly attributed to the senescence-associated secretory phenotype (SASP)...
March 14, 2018: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/29544367/upregulation-of-s100a6-in-patients-with-endometriosis-and-its-role-in-ectopic-endometrial-stromal-cells
#3
Yaoming Peng, Jiabin Lin, Junyan Ma, Kaiqing Lin, Kaihong Xu, Jun Lin
S100 calcium-binding protein A6 (S100A6) is up-regulated in many malignancies and overexpression of S100A6 has been identified associated with proliferation, migration and invasion phenotype in several cancer cells. In the present study, we explored whether S100A6 plays a role in the development of endometriosis. Significantly higher levels of mRNA and protein expression of S100A6 were observed in ectopic endometrial tissues compared to eutopic and normal endometrial tissues. Silencing of S100A6 in ectopic endometrial stromal cells (ESCs) significantly inhibited cell viability, migration and invasion...
March 16, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29534068/the-effect-of-s100a6-on-nuclear-translocation-of-cacybp-sip-in-colon-cancer-cells
#4
Shanshan Feng, Qiaozhi Zhou, Bo Yang, Qianqian Li, Aiqin Liu, Yingying Zhao, Changqing Qiu, Jun Ge, Huihong Zhai
BACKGROUND: Calcyclin Binding Protein/(Siah-1 interacting protein) (CacyBP/SIP) acts as an oncogene in colorectal cancer. The nuclear accumulation of CacyBP/SIP has been linked to the proliferation of cancer cells. It has been reported that intracellular Ca2+ induces the nuclear translocation of CacyBP/SIP. However, the molecular mechanism of CacyBP/SIP nuclear translocation has yet to be elucidated. The purpose of this study was to test whether the Ca2+-dependent binding partner S100 protein is involved in CacyBP/SIP nuclear translocation in colon cancer SW480 cells...
2018: PloS One
https://www.readbyqxmd.com/read/29441475/robot-assisted-distal-gastrectomy-with-lymph-node-dissection-for-gastric-cancer-in-a-patient-with-situs-inversus-partialis-a-case-report-with-video-file
#5
Yuki Aisu, Yoshio Kadokawa, Shigeru Kato, Daiki Yasukawa, Yusuke Kimura, Tomohide Hori
BACKGROUND: Situs inversus is a rare congenital condition that is currently classified into two types: complete situs inversus (situs inversus totalis, SIT) and partial situs inversus (situs inversus partialis, SIP). In SIP patients, some organs are inverted and others are in their expected position, and individual patient variation in organ position increases surgical difficulty. Several surgeons have performed laparoscopic or robotic surgeries in situs inversus patients, but almost all were SIT patients...
February 13, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29348080/squid-ink-polysaccharide-prevents-chemotherapy-induced-injury-in-the-testes-of-reproducing-mice
#6
Ping Luo, Hua-Zhong Liu, Xiao-Yan Le, Hui Du, Xin-Huang Kang
The present study was conducted to investigate the preventive effects of squid ink polysaccharides (SIP) on the damage of sperm and reproduction induced by cyclophosphamide that is most commonly used for treating clinically cancers. Male Kunming mice exposed to cyclophosphamide were administered with SIP and were sacrificed to determine sperm parameters, testicular antioxidant ability and reproductive capacity. Data indicated that cyclophosphamide caused obvious changes in mice such as significant reduction (P<0...
January 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29197151/transcriptional-regulation-of-cacybp-sip-gene-and-the-influence-of-increased-cacybp-sip-level-on-gene-expression-pattern-in-colorectal-cancer-hct116-cells
#7
Beata Kądziołka, Konrad J Dębski, Paweł Bieganowski, Wiesława Leśniak, Anna Filipek
The CacyBP/SIP protein is expressed at a particularly high level in brain, spleen, and various tumors. In this work, we have studied transcriptional regulation of the CacyBP/SIP gene and the influence of increased CacyBP/SIP level on gene expression in colorectal cancer HCT116 cells. We have shown that E2F1, EGR1, and CREB transcription factors bind to the CacyBP/SIP gene promoter and stimulate transcription of CacyBP/SIP gene. The role of CREB was further confirmed by the observation that forskolin, a strong activator of CREB phosphorylation/activity, increased CacyBP/SIP gene promoter activity...
January 2018: IUBMB Life
https://www.readbyqxmd.com/read/29143796/angelica-sinensis-polysaccharides-ameliorate-stress-induced-premature-senescence-of-hematopoietic-cell-via-protecting-bone-marrow-stromal-cells-from-oxidative-injuries-caused-by-5-fluorouracil
#8
Hanxianzhi Xiao, Lirong Xiong, Xiaoying Song, Pengwei Jin, Linbo Chen, Xiongbin Chen, Hui Yao, Yaping Wang, Lu Wang
Myelosuppression is the most common complication of chemotherapy. Decline of self-renewal capacity and stress-induced premature senescence (SIPS) of hematopoietic stem cells (HSCs) induced by chemotherapeutic agents may be the cause of long-term myelosuppression after chemotherapy. Whether the mechanism of SIPS of hematopoietic cells relates to chemotherapeutic injury occurred in hematopoietic microenvironment (HM) is still not well elucidated. This study explored the protective effect of Angelica sinensis polysaccharide (ASP), an acetone extract polysaccharide found as the major effective ingredients of a traditional Chinese medicinal herb named Chinese Angelica (Dong Quai), on oxidative damage of homo sapiens bone marrow/stroma cell line (HS-5) caused by 5-fluorouracil (5-FU), and the effect of ASP relieving oxidative stress in HM on SIPS of hematopoietic cells...
October 28, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29099417/cell-cycle-dependent-translocation-and-regulatory-mechanism-of-cacybp-sip-in-gastric-cancer-cells
#9
Yang Chen, Kun Zhang, Xiaosu Wang, Qiaoneng Li, Qingfeng Wu, Xiaoxuan Ning
Our previous results showed that calcyclin-binding protein/Siah-1-interacting protein (CacyBP/SIP) inhibits the proliferation and tumorigenicity of gastric cancer; however, the exact mechanism remains unclear, especially from the aspect of cell cycle. The subcellular localization of CacyBP/SIP, Siah-1, and Skp1 in SGC7901 gastric cancer cells was assessed by immunofluorescence after cell cycle synchronization. Levels of CacyBP/SIP, Siah-1, Skp1, β-catenin, and p-ERK1/2 were analyzed by western blotting. CacyBP/SIP phosphorylation (p-CacyBP/SIP) and the combining capacity of Siah-1 and Skp1 with CacyBP/SIP in nucleoprotein were determined by immunoprecipitation...
January 2018: Anti-cancer Drugs
https://www.readbyqxmd.com/read/29075971/minimally-invasive-surgery-as-a-treatment-option-for-gastric-cancer-with-liver-metastasis-a-comparison-with-open-surgery
#10
Jiyang Li, Hongqing Xi, Jianxin Cui, Kecheng Zhang, Yunhe Gao, Wenquan Liang, Aizhen Cai, Bo Wei, Lin Chen
BACKGROUND: As minimally invasive techniques advances, minimally invasive surgery (MIS) has emerged as an alternative modality for advanced gastric cancer. In this study, we compared the short- and long-term surgical outcomes of MIS and conventional open surgery for gastric cancer liver metastasis (GCLM) in terms of safety, feasibility, and efficacy. METHODS: This retrospective study used data from a prospective database at the Chinese People's Liberation Army General Hospital...
March 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29053388/some-chemotherapeutics-treated-colon-cancer-cells-display-a-specific-phenotype-being-a-combination-of-stem-like-and-senescent-cell-features
#11
H Was, J Czarnecka, A Kominek, K Barszcz, T Bernas, K Piwocka, B Kaminska
Colorectal cancer (CRC) is the second leading cause of death among cancer patients in the Northern countries. CRC can reappear a long time after treatment. Recent clinical studies demonstrated that, in response to chemotherapy, cancer cells may undergo stress-induced premature senescence (SIPS), which typically results in growth arrest. Nonetheless, these senescent cells were reported to divide in an atypical manner and thus contribute to cancer re-growth. Therefore, we examined if SIPS escape may follow treatment with chemotherapeutics used clinically: 5-fluorouracil (5-FU), oxaliplatin (OXA) and irinotecan (IRINO)...
January 2, 2018: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/28948442/correlation-between-voxel-wise-enhancement-parameters-on-dce-mri-and-pathological-prognostic-factors-in-invasive-breast-cancers
#12
Rubina Manuela Trimboli, Marina Codari, Katia Khouri Chalouhi, Ileana Ioan, Giovanna Lo Bue, Arianna Ottini, Daniela Casolino, Luca Alessandro Carbonaro, Francesco Sardanelli
PURPOSE: To investigate the correlation between enhancement parameters on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and pathologic prognostic factors in invasive breast cancers (BCs). MATERIALS AND METHODS: A total of 25 invasive BCs were included: 22 invasive ductal, 2 invasive lobular and 1 invasive mucinous. The tumor volume was segmented using a semi-automatic software (Olea Sphere). The following voxel-wise enhancement parameters were extracted: (1) time to peak enhancement; (2) signal intensity at peak (SIP); (3) peak enhancement percentage (PEP); (4) post-initial enhancement percentage (PIEP)...
February 2018: La Radiologia Medica
https://www.readbyqxmd.com/read/28870748/sulfated-polysaccharide-of-sepiella-maindroni-ink-inhibits-the-migration-invasion-and-matrix-metalloproteinase-2-expression-through-suppressing-egfr-mediated-p38-mapk-and-pi3k-akt-mtor-signaling-pathways-in-skov-3-cells
#13
Wenjie Jiang, Yanna Cheng, Na Zhao, Lian Li, Yikang Shi, Aizhen Zong, Fengshan Wang
Previous studies demonstrated that SIP-SII, a sulfated derivative of SIP that is isolated from the ink of Sepiella maindroni, showed significant inhibition of tumor growth and metastasis. In this study, the effects of SIP-SII on the migration, invasion and molecular mechanism in ovarian cancer cell line, SKOV-3 cells, were investigated. The flow cytometry, confocal microscope observation, western blot and RT-PCR results indicated that SIP-SII located on cell membrane and inhibited the expression and activation of epidermal growth factor receptor (EGFR)...
February 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28830011/inhibition-of-egf-induced-migration-and-invasion-by-sulfated-polysaccharide-of-sepiella-maindroni-ink-via-the-suppression-of-egfr-akt-p38-mapk-mmp-2-signaling-pathway-in-kb-cells
#14
Wenjie Jiang, Weilu Tian, Muhammad Ijaz, Fengshan Wang
SIP-SII, the sulfated Sepiella maindroni ink polysaccharide (SIP), has been manifested to possess anti-tumor and anti-metastasis activity in vivo and in vitro. In the present study, we evaluated its inhibitory effect on the epidermal growth factor (EGF)-induced migration and invasion of human epidermoid carcinoma cell (KB cell line) as well as the related signaling pathways. The results of MTT assay indicated that SIP-SII inhibited the proliferation of KB cells in a concentration and time dependent manner. Notably, the attenuation of cell growth by SIP-SII was enlarged in the presence of EGF...
November 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28806761/transcriptome-analysis-of-pdgfr%C3%AE-cells-identifies-t-type-ca2-channel-cacna1g-as-a-new-pathological-marker-for-pdgfr%C3%AE-cell-hyperplasia
#15
Se Eun Ha, Moon Young Lee, Masaaki Kurahashi, Lai Wei, Brian G Jorgensen, Chanjae Park, Paul J Park, Doug Redelman, Kent C Sasse, Laren S Becker, Kenton M Sanders, Seungil Ro
Platelet-derived growth factor receptor alpha (PDGFRα)+ cells are distributed into distinct morphological groups within the serosal, muscular, and submucosal layers as well as the myenteric and deep muscular plexi. PDGFRα+ cells directly interact with interstitial cells of Cajal (ICC) and smooth muscle cells (SMC) in gastrointestinal smooth muscle tissue. These three cell types, SMC, ICC, and PDGFRα+ cells (SIP cells), form an electrical syncytium, which dynamically regulates gastrointestinal motility. We have previously reported the transcriptomes of SMC and ICC...
2017: PloS One
https://www.readbyqxmd.com/read/28746345/cisplatin-resistance-in-non-small-cell-lung-cancer-cells-is-associated-with-an-abrogation-of-cisplatin-induced-g2-m-cell-cycle-arrest
#16
Navin Sarin, Florian Engel, Ganna V Kalayda, Mareike Mannewitz, Jindrich Cinatl, Florian Rothweiler, Martin Michaelis, Hisham Saafan, Christoph A Ritter, Ulrich Jaehde, Roland Frötschl
The efficacy of cisplatin-based chemotherapy in cancer is limited by the occurrence of innate and acquired drug resistance. In order to better understand the mechanisms underlying acquired cisplatin resistance, we have compared the adenocarcinoma-derived non-small cell lung cancer (NSCLC) cell line A549 and its cisplatin-resistant sub-line A549rCDDP2000 with regard to cisplatin resistance mechanisms including cellular platinum accumulation, DNA-adduct formation, cell cycle alterations, apoptosis induction and activation of key players of DNA damage response...
2017: PloS One
https://www.readbyqxmd.com/read/28478937/coexpression-of-growth-differentiation-factor-11-and-reactive-oxygen-species-in-metastatic-oral-cancer-and-its-role-in-inducing-the-epithelial-to-mesenchymal-transition
#17
Xiangming Qin, Hai Kuang, Lei Chen, Shanliang Wei, Dahai Yu, Feixin Liang
OBJECTIVES: The aim of this study was to investigate growth differentiation factor 11 (GDF11) and reactive oxygen species (ROS) expression in metastatic oral cancer and explored their roles in inducing epithelial to mesenchymal transition (EMT). STUDY DESIGN: The expression of GDF11, ROS, and EMT-related markers was evaluated in primary tumor tissues from patients with oral squamous cell carcinoma (OSCC). SCC-9 cells, a human tongue carcinoma cell line, were treated with recombinant GDF11...
June 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28416275/cisplatin-analogs-confer-protection-against-cyanide-poisoning
#18
Anjali K Nath, Xu Shi, Devin L Harrison, Jordan E Morningstar, Sari Mahon, Adriano Chan, Patrick Sips, Jangwoen Lee, Calum A MacRae, Gerry R Boss, Matthew Brenner, Robert E Gerszten, Randall T Peterson
Cisplatin holds an illustrious position in the history of chemistry most notably for its role in the virtual cure of testicular cancer. Here we describe a role for this small molecule in cyanide detoxification in vivo. Cyanide kills organisms as diverse as insects, fish, and humans within seconds to hours. Current antidotes exhibit limited efficacy and are not amenable to mass distribution requiring the development of new classes of antidotes. The binding affinity of the cyanide anion for the positively charged metal platinum is known to create an extremely stable complex in vitro...
May 18, 2017: Cell Chemical Biology
https://www.readbyqxmd.com/read/28388095/biomimetic-bacterial-identification-platform-based-on-thermal-wave-transport-analysis-twta-through-surface-imprinted-polymers
#19
Erik Steen Redeker, Kasper Eersels, Onno Akkermans, Jeroen Royakkers, Simba Dyson, Kunya Nurekeyeva, Beniamino Ferrando, Peter Cornelis, Marloes Peeters, Patrick Wagner, Hanne Diliën, Bart van Grinsven, Thomas Jan Cleij
This paper introduces a novel bacterial identification assay based on thermal wave analysis through surface-imprinted polymers (SIPs). Aluminum chips are coated with SIPs, serving as synthetic cell receptors that have been combined previously with the heat-transfer method (HTM) for the selective detection of bacteria. In this work, the concept of bacterial identification is extended toward the detection of nine different bacterial species. In addition, a novel sensing approach, thermal wave transport analysis (TWTA), is introduced, which analyzes the propagation of a thermal wave through a functional interface...
May 12, 2017: ACS Infectious Diseases
https://www.readbyqxmd.com/read/28361045/phase-i-clinical-trial-of-sipuleucel-t-combined-with-escalating-doses-of-ipilimumab-in-progressive-metastatic-castrate-resistant-prostate-cancer
#20
Mark Scholz, Sabrina Yep, Micah Chancey, Colleen Kelly, Ken Chau, Jeffrey Turner, Richard Lam, Charles G Drake
BACKGROUND: Sipuleucel-T (SIP-T), which functions by stimulating cancer-specific dendritic cells, prolongs survival in men with prostate cancer. Ipilimumab (IPI) achieved a borderline survival advantage in a large randomized trial. SIP-T and IPI are potentially synergistic. PATIENTS AND METHODS: Nine men with progressive metastatic castrate-resistant prostate cancer (mCRPC) were treated prospectively with SIP-T followed immediately by IPI with one of the following doses of IPI: 1 mg/kg at 1 week after SIP-T; 1 mg/kg at 1 and 4 weeks after SIP-T; or 1 mg/kg at 1, 4, and 7 weeks after SIP-T...
2017: ImmunoTargets and Therapy
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