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https://www.readbyqxmd.com/read/27637491/chemotherapy-appointment-scheduling-under-uncertainty-using-mean-risk-stochastic-integer-programming
#1
Michelle Alvarado, Lewis Ntaimo
Oncology clinics are often burdened with scheduling large volumes of cancer patients for chemotherapy treatments under limited resources such as the number of nurses and chairs. These cancer patients require a series of appointments over several weeks or months and the timing of these appointments is critical to the treatment's effectiveness. Additionally, the appointment duration, the acuity levels of each appointment, and the availability of clinic nurses are uncertain. The timing constraints, stochastic parameters, rising treatment costs, and increased demand of outpatient oncology clinic services motivate the need for efficient appointment schedules and clinic operations...
September 16, 2016: Health Care Management Science
https://www.readbyqxmd.com/read/27246693/cristacarpin-promotes-er-stress-mediated-ros-generation-leading-to-premature-senescence-by-activation-of-p21-waf-1
#2
Souneek Chakraborty, Reyaz Ur Rasool, Sunil Kumar, Debasis Nayak, Bilal Rah, Archana Katoch, Hina Amin, Asif Ali, Anindya Goswami
Stress-induced premature senescence (SIPS) is quite similar to replicative senescence that is committed by cells exposed to various stress conditions viz. ultraviolet radiation (DNA damage), hydrogen peroxide (oxidative stress), chemotherapeutic agents (cytotoxic threat), etc. Here, we report that cristacarpin, a natural product obtained from the stem bark of Erythrina suberosa, promotes endoplasmic reticulum (ER) stress, leading to sub-lethal reactive oxygen species (ROS) generation and which eventually terminates by triggering senescence in pancreatic and breast cancer cells through blocking the cell cycle in the G1 phase...
June 2016: Age (2005-)
https://www.readbyqxmd.com/read/27219115/effect-of-acupuncture-on-reducing-duration-of-postoperative-ileus-after-gastrectomy-in-patients-with-gastric-cancer-a-pilot-study-using-sitz-marker
#3
Hyun-Dong Chae, Min-Ah Kwak, In-Hwan Kim
OBJECTIVES: Postoperative ileus (POI) is a common problem after abdominal surgery. Acupuncture is being accepted as an option for reducing POI and managing various functional gastrointestinal disorders. Therefore, this pilot study was conducted to evaluate the effect of acupuncture on reducing duration of POI and other surgical outcomes in patients who underwent gastric surgery. DESIGN: A prospective, randomized, controlled pilot study was conducted on patients who underwent gastric cancer surgery from January 2013 to December 2013...
June 2016: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/27138192/immunohistochemical-study-emt-related-proteins-in-hpv-and-ebv-negative-patients-with-sinonasal-tumours
#4
Olga Stasikowska-Kanicka, Małgorzata Wągrowska-Danilewicz, Marian Danilewicz
Epithelial to mesenchymal transition (EMT) is a biological process in which the epithelial cells, transform to mesenchymal cells via multiple biochemical modifications. Immunohistochemical method was used to examine the expression of EMT-related proteins: Slug, E-cadherin and fibronectin, in 41 cases of sinonasal inverted papilloma (SIP), 33 cases of sinonasal squamous cell carcinoma (SNC), and 22 cases of normal mucosa as a control. In all cases negative viral status was previously confirmed using both in situ hybridization and immunohistochemical method...
October 2016: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/27110866/initial-experience-of-restorative-proctocolectomy-for-ulcerative-colitis-by-transanal-total-mesorectal-rectal-excision-and-single-incision-abdominal-laparoscopic-surgery
#5
C A Leo, S Samaranayake, Z L Perry-Woodford, L Vitone, O Faiz, J D Hodgkinson, I Shaikh, J Warusavitarne
AIM: Laparoscopic surgery is well established for colon cancer, with defined benefits. Use of laparoscopy for the performance of restorative proctocolectomy (RPC) with ileoanal anastomosis is more controversial. Technical aspects include difficult dissection of the distal rectum and a potentially increased risk of anastomotic leakage through multiple firings of the stapler. In an attempt to overcome these difficulties we have used the technique of transanal rectal excision to perform the proctectomy...
December 2016: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/27099442/cacybp-sip-nuclear-translocation-regulates-p27kip1-stability-in-gastric-cancer-cells
#6
Ying-Lin Niu, Ya-Jun Li, Jing-Bo Wang, Yuan-Yuan Lu, Zhen-Xiong Liu, Shan-Shan Feng, Jian-Guo Hu, Hui-Hong Zhai
AIM: To investigate the mechanism of calcyclin binding protein/Siah-1 interacting protein (CacyBP/SIP) nuclear translocation in promoting the proliferation of gastric cancer (GC) cells. METHODS: The effect of CacyBP/SIP nuclear translocation on cell cycle was investigated by cell cycle analysis. Western blot analysis was used to assess the change in expression of cell cycle regulatory proteins and proteasome-mediated degradation of p27Kip1. Co-immunoprecipitation (co-IP) analysis was performed to examine the binding of CacyBP/SIP with Skp1...
April 21, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/26936678/sip-jeon-dea-bo-tang-a-traditional-herbal-medicine-ameliorates-cisplatin-induced-anorexia-via-the-activation-of-jak1-stat3-mediated-leptin-and-il-6-production-in-the-fat-tissue-of-mice
#7
Sang-Mi Woo, Youn Kyung Choi, Ah-Jeong Kim, Yee Jin Yun, Yong Cheol Shin, Sung-Gook Cho, Seong Gyu Ko
Despite its therapeutic advantages, chemotherapy can also cause adverse effects, including anorexia and loss of appetite. Although numerous patients with cancer have been reported to suffer from anorexia during or following chemotherapy, treatment options for anorexia remain to be determined. In Asian countries, traditional medicines are widely used to treat problems with appetite; sip-jeon-dea-bo-tang (SJDBT) is one of those medicines used for the treatment of anorexia. The present study demonstrated that SJDBT ameliorated cisplatin-induced anorexia...
April 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/26873490/the-potential-role-of-cacybp-sip-in-tumorigenesis
#8
Xiaoxuan Ning, Yang Chen, Xiaosu Wang, Qiaoneng Li, Shiren Sun
Calcyclin-binding protein/Siah-1-interacting protein (CacyBP/SIP) was initially described as a binding partner of S100A6 in the Ehrlich ascites tumor cells and later as a Siah-1-interacting protein. This 30 kDa protein includes three domains and is involved in cell proliferation, differentiation, cytoskeletal rearrangement, and transcriptional regulation via binding to various proteins. Studies have also shown that the CacyBP/SIP is a critical protein in tumorigenesis. But, its promotion or suppression of cancer progression may depend on the cell type...
August 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/26812514/effectiveness-of-food-based-fortification-in-older-people-a-systematic-review-and-meta-analysis
#9
REVIEW
J C Morilla-Herrera, F J Martín-Santos, J Caro-Bautista, C Saucedo-Figueredo, S García-Mayor, J M Morales-Asencio
BACKGROUND: Early intervention with nutritional support has been found to stop weight loss in older people malnourished or at risk of malnutrition. Enriched food could be a more attractive alternative to improve meals, than conventional oral nutritional supplements. AIMS: To determine the effectiveness of food-based fortification to prevent risk of malnutrition in elderly patients in community or institutionalized elderly patients. METHODS: A systematic review was conducted of randomized controlled trials, quasi-experimental, and interrupted time series including a longitudinal analysis...
February 2016: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/26477465/morphological-and-functional-characteristic-of-senescent-cancer-cells
#10
REVIEW
Ewa Sikora, Grazyna Mosieniak, Malgorzata Alicja Sliwinska
Cellular senescence is the state of permanent proliferation cessation. There are two types of cell senescence. One is replicative senescence, which relies on telomere length-dependent limit of cell divisions. The second is stress-induced premature senescence (SIPS) which is telomere- independent. Cell senescence is a barrier to cancer. Paradoxically senescent cells, which are metabolically active secrete factors which can be procancerogenic. The main culprit of cell senescence is DNA damage and DNA damage response...
2016: Current Drug Targets
https://www.readbyqxmd.com/read/26294742/antibody-format-and-drug-release-rate-determine-the-therapeutic-activity-of-noninternalizing-antibody-drug-conjugates
#11
Rémy Gébleux, Sarah Wulhfard, Giulio Casi, Dario Neri
The development of antibody-drug conjugates (ADC), a promising class of anticancer agents, has traditionally relied on the use of antibodies capable of selective internalization in tumor cells. We have recently shown that also noninternalizing antibodies, coupled to cytotoxic drugs by means of disulfide linkers that can be cleaved in the tumor extracellular environment, can display a potent therapeutic activity. Here, we have compared the tumor-targeting properties, drug release rates, and therapeutic performance of two ADCs, based on the maytansinoid DM1 thiol drug and on the F8 antibody, directed against the alternatively spliced Extra Domain A (EDA) domain of fibronectin...
November 2015: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/26137007/role-of-the-cacybp-sip-protein-in-gastric-cancer
#12
Huihong Zhai, Juan Meng, Haifeng Jin, Yuanfei Li, Jinbo Wang
Various reports indicate that calcyclin binding protein/Siah-1-interacting protein (CacyBP/SIP) is an important protein in tumorigenesis, but whether CacyBP/SIP promotes or suppresses cancer may depend on the cell type. In order to investigate whether CacyBP/SIP is significant in gastric cancerous tumorigenesis, the present study used immunohistochemistry to analyze 181 gastric cancer tissue samples, as well as 181 healthy tissue samples from the same gastric cancer patients. The immunohistochemical results were compared against patient data and pathological analysis of the tissue slices, including gender, age, degree of tumor differentiation and tumor, node, metastasis (TNM) stage...
May 2015: Oncology Letters
https://www.readbyqxmd.com/read/25775370/use-of-vinegar-to-relieve-persistent-hiccups-in-an-advanced-cancer-patient
#13
Silvia Gonella, Flavia Gonella
BACKGROUND: This case report describes a patient whose persistent hiccups significantly improved with the use of vinegar. CASE PRESENTATION: A patient with an adenocarcinoma of the colon and hepatic metastases developed hiccups the day following chemotherapy with FOL-FOX (folinic acid (leucovorin), 5-fluorouracil, oxaliplatin). Hiccups continued for seven days with no improvement from a number of commonly used pharmacological agents (chlorpromazine, metoclopramide, haloperidol, and baclofen)...
May 2015: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/25752114/-the-management-of-sinonasal-inverted-papilloma-by-endoscopic-surgery-an-analysis-of-54-cases
#14
Xu Wu, Dong Sun, Xianying Meng, Yibing Yuan
OBJECTIVE: The study is to evaluate our results of patients with sinonasal inverted papilloma (SIP) undergoing endoscopic sinus surgery and to investigate the recurrence relative factors of SIP. METHOD: A retrospec- tive analysis was performed of medical records for 54 cases SIP treated with endoscopic resection. Compared to pre operation imaging evaluation and intraoperative observation, efficacy assessments included endoscopy during follow-up after operation and combined with CT examination results...
November 2014: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/25673532/stress-induced-premature-senescence-a-new-culprit-in-ovarian-tumorigenesis
#15
REVIEW
Gorantla Venkata Raghuram, Pradyumna Kumar Mishra
Stress induced premature senescence (SIPS) is a relative extension to the concept of exogenous cellular insult. Besides persistent double strand (ds) DNA breaks and increased β-galactosidase activity, biological significance of telomeric attrition in conjunction with senescence associated secretory phenotype (SASP) has been highlighted in SIPS. To gain insight on the potential role of this unique phenomenon invoked upon environmental stress, we sequentially validated the molecular repercussions of this event in ovarian epithelial cells after exposure to methyl isocyanate, an elegant regulator of cellular biotransformation...
November 2014: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/25654744/heat-transfer-method-based-cell-culture-quality-assay-through-cell-detection-by-surface-imprinted-polymers
#16
Kasper Eersels, Bart van Grinsven, Mehran Khorshid, Veerle Somers, Christiane Püttmann, Christoph Stein, Stefan Barth, Hanne Diliën, Gerard M J Bos, Wilfred T V Germeraad, Thomas J Cleij, Ronald Thoelen, Ward De Ceuninck, Patrick Wagner
Previous work has indicated that surface imprinted polymers (SIPs) allow for highly specific cell detection through macromolecular cell imprints. The combination of SIPs with a heat-transfer-based read-out technique has led to the development of a selective, label-free, low-cost, and user-friendly cell detection assay. In this study, the breast cancer cell line ZR-75-1 is used to assess the potential of the platform for monitoring the quality of a cell culture in time. For this purpose, we show that the proposed methodology is able to discriminate between the original cell line (adherent growth, ZR-75-1a) and a descendant cell line (suspension growth, ZR-75-1s)...
February 17, 2015: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/25568512/impact-of-complications-and-bladder-cancer-stage-on-quality-of-life-in-patients-with-different-types-of-urinary-diversions
#17
Alden Prcic, Damir Aganovic, Osman Hadziosmanovic
GOAL: Determine correlation between complications and stage of the disease and their impact on quality of life in patients with different types of ileal urinary derivation after radical cystectomy, and upon estimation of acquired results, to suggest the most acceptable type of urinary diversion. PATIENTS AND METHODS: In five year period a prospective clinical study was performed on 106 patients, to whom a radical cystectomy was performed due to bladder cancer. Patients were divided into two groups, 66 patients with ileal conduit derivation and 40 patients with orthotopic derivation, whereby in each group a comparison between reflux and anti-reflux technique of orthotopic bladder was made...
December 2013: Medical Archives
https://www.readbyqxmd.com/read/25514092/bacillus-thuringiensis-toxins-an-overview-of-their-biocidal-activity
#18
REVIEW
Leopoldo Palma, Delia Muñoz, Colin Berry, Jesús Murillo, Primitivo Caballero
Bacillus thuringiensis (Bt) is a Gram positive, spore-forming bacterium that synthesizes parasporal crystalline inclusions containing Cry and Cyt proteins, some of which are toxic against a wide range of insect orders, nematodes and human-cancer cells. These toxins have been successfully used as bioinsecticides against caterpillars, beetles, and flies, including mosquitoes and blackflies. Bt also synthesizes insecticidal proteins during the vegetative growth phase, which are subsequently secreted into the growth medium...
2014: Toxins
https://www.readbyqxmd.com/read/25110433/cacybp-sip-nuclear-translocation-induced-by-gastrin-promotes-gastric-cancer-cell-proliferation
#19
Hui-Hong Zhai, Juan Meng, Jing-Bo Wang, Zhen-Xiong Liu, Yuan-Fei Li, Shan-Shan Feng
AIM: To investigate the role of nuclear translocation of calcyclin binding protein, also called Siah-1 interacting protein (CacyBP/SIP), in gastric carcinogenesis. METHODS: The expression of CacyBP/SIP protein in gastric cancer cell lines was detected by Western blot. Immunofluorescence experiments were performed on gastric cancer cell lines that had been either unstimulated or stimulated with gastrin. To confirm the immunofluorescence findings, the relative abundance of CacyBP/SIP in nuclear and cytoplasmic compartments was assessed by Western blot...
August 7, 2014: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/25109605/sphk1-confers-resistance-to-apoptosis-in-gastric-cancer-cells-by-downregulating-bim-via-stimulating-akt-foxo3a-signaling
#20
Huaping Xiong, Jicheng Wang, Hongyu Guan, Jueheng Wu, Ru Xu, Min Wang, Xia Rong, Ke Huang, Jieting Huang, Qiao Liao, Yongshui Fu, Jie Yuan
We previously reported that sphingosine kinase 1 (SphK1), an enzyme that catalyzes the production of sphingosine-1-phosphate (SIP), is upregulated in human gastric cancer and predicts poor clinical outcome. In the present study, we used known differential effects of UV irradiation on human MGC-803 gastric cancer cells to determine their effect on SphK1 activity. Ectopic expression of SphK1 in MGC-803 gastric cancer cells markedly enhanced their resistance to UV irradiation, whereas silencing endogenous SphK1 with shRNAs weakened this ability...
October 2014: Oncology Reports
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