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https://www.readbyqxmd.com/read/27896988/precision-medicine-data-and-discovery-for-improved-health-and-therapy
#1
Alexander A Morgan, Dana C Crawford, Josh C Denny, Sean D Mooney, Bruce J Aronow, Steven E Brenner
The major goal of precision medicine is to improve human health. A feature that unites much research in the field is the use of large datasets such as genomic data and electronic health records. Research in this field includes examination of variation in the core bases of DNA and their methylation status, through variations in metabolic and signaling molecules, all the way up to broader systems level changes in physiology and disease presentation. Intermediate goals include understanding the individual drivers of disease that differentiate the cause of disease in each individual...
2016: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/27895956/steps-in-moving-evidence-based-health-informatics-from-theory-to-practice
#2
REVIEW
Michael Rigby, Farah Magrabi, Philip Scott, Persephone Doupi, Hannele Hypponen, Elske Ammenwerth
OBJECTIVES: To demonstrate and promote the importance of applying a scientific process to health IT design and implementation, and of basing this on research principles and techniques. METHODS: A review by international experts linked to the IMIA Working Group on Technology Assessment and Quality Development. RESULTS: Four approaches are presented, linking to the creation of national professional expectations, adherence to research-based standards, quality assurance approaches to ensure safety, and scientific measurement of impact...
October 2016: Healthcare Informatics Research
https://www.readbyqxmd.com/read/27893907/patterns-and-perceptions-of-asynchronous-video-discussion-in-a-graduate-health-sciences-course
#3
Mollie Cummins, Naresh Sundar Rajan, Chad Hodge, Ramkiran Gouripeddi
BACKGROUND: Studies of graduate online education indicate a need for increased interaction among students and faculty. However, it can be challenging to foster a high level of scholarly interaction and engagement in fully online courses. The objective of this study was to evaluate student perceptions and participation patterns related to online, asynchronous video discussion in a graduate health sciences course. METHOD: An asynchronous video discussion was piloted in a 2014 interprofessional informatics course and students were subsequently surveyed to determine their perceptions of this approach...
December 1, 2016: Journal of Nursing Education
https://www.readbyqxmd.com/read/27893502/implementing-a-4c-approach-to-quality-improvement
#4
Michelle McGonigal
Designing a quality improvement activity can be labor intensive and intimidating to facilitators who have not been specially trained in process improvement methodologies. To simplify the process, a team was formed with the specific task of developing a basic model that addresses key concepts in change theory. The 2010 Institute of Medicine report stresses the importance of health care professionals working together, collaboratively, to use data to improve patient outcomes and improve care nationally. In addition, as noted in Quality and Safety Education for Nurses (2013), competencies have been developed to promote frontline problem solving including using data for quality improvement, providing safe care, functioning in collaborative teams, respecting and addressing patient and family concerns, applying evidence-based practice, and using informatics to make decisions...
January 2017: Critical Care Nursing Quarterly
https://www.readbyqxmd.com/read/27891528/preparing-nursing-home-data-from-multiple-sites-for-clinical-research-a-case-study-using-observational-health-data-sciences-and-informatics
#5
Richard D Boyce, Steven M Handler, Jordan F Karp, Subashan Perera, Charles F Reynolds
INTRODUCTION: A potential barrier to nursing home research is the limited availability of research quality data in electronic form. We describe a case study of converting electronic health data from five skilled nursing facilities to a research quality longitudinal dataset by means of open-source tools produced by the Observational Health Data Sciences and Informatics (OHDSI) collaborative. METHODS: The Long-Term Care Minimum Data Set (MDS), drug dispensing, and fall incident data from five SNFs were extracted, translated, and loaded into version 4 of the OHDSI common data model...
2016: EGEMS
https://www.readbyqxmd.com/read/27885364/bidirectional-rnn-for-medical-event-detection-in-electronic-health-records
#6
Abhyuday N Jagannatha, Hong Yu
Sequence labeling for extraction of medical events and their attributes from unstructured text in Electronic Health Record (EHR) notes is a key step towards semantic understanding of EHRs. It has important applications in health informatics including pharmacovigilance and drug surveillance. The state of the art supervised machine learning models in this domain are based on Conditional Random Fields (CRFs) with features calculated from fixed context windows. In this application, we explored recurrent neural network frameworks and show that they significantly out-performed the CRF models...
June 2016: Proceedings of the Conference
https://www.readbyqxmd.com/read/27880746/notice-to-readers-nndss-tables-have-updated-n-indicators-for-2015-and-2016
#7
(no author information available yet)
CDC's National Notifiable Diseases Surveillance System (NNDSS) maintains and annually updates information about whether each Nationally Notifiable Infectious Condition (NNIC) is considered "reportable" (by health care providers, hospitals, laboratories, or other public health reporters) in each reporting jurisdiction. NNDSS personnel within the Division of Health Informatics and Surveillance performed assessments with each reporting jurisdiction to ascertain the reportable disease status of each NNIC for 2015 and 2016...
November 25, 2016: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/27880717/health-informatics-our-domain-our-challenge
#8
Douglas B Fridsma
No abstract text is available yet for this article.
November 2016: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/27875988/common-data-elements-for-secondary-use-of-electronic-health-record-data-for-clinical-trial-execution-and-serious-adverse-event-reporting
#9
Philipp Bruland, Mark McGilchrist, Eric Zapletal, Dionisio Acosta, Johann Proeve, Scott Askin, Thomas Ganslandt, Justin Doods, Martin Dugas
BACKGROUND: Data capture is one of the most expensive phases during the conduct of a clinical trial and the increasing use of electronic health records (EHR) offers significant savings to clinical research. To facilitate these secondary uses of routinely collected patient data, it is beneficial to know what data elements are captured in clinical trials. Therefore our aim here is to determine the most commonly used data elements in clinical trials and their availability in hospital EHR systems...
November 22, 2016: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/27866956/accuracy-and-completeness-of-drug-information-in-wikipedia-medication-monographs
#10
Timothy Reilly, William Jackson, Victoria Berger, Danielle Candelario
OBJECTIVES: The primary objective of this study was to determine the accuracy and completeness of drug information on Wikipedia and Micromedex compared with U.S. Food and Drug Administration-approved U.S. product inserts. METHODS: The top 10 brand and top 10 generic medications from the 2012 Institute for Health Informatics' list of top 200 drugs were selected for evaluation. Wikipedia medication information was evaluated and compared with Micromedex in 7 sections of drug information; the U...
November 17, 2016: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/27864204/integrating-pharmacogenomics-into-electronic-health-records-with-clinical-decision-support
#11
J Kevin Hicks, Henry M Dunnenberger, Karl F Gumpper, Cyrine E Haidar, James M Hoffman
PURPOSE: Existing pharmacogenomic informatics models, key implementation steps, and emerging resources to facilitate the development of pharmacogenomic clinical decision support (CDS) are described. SUMMARY: Pharmacogenomics is an important component of precision medicine. Informatics, especially CDS in the electronic health record (EHR), is a critical tool for the integration of pharmacogenomics into routine patient care. Effective integration of pharmacogenomic CDS into the EHR can address implementation challenges, including the increasing volume of pharmacogenomic clinical knowledge, the enduring nature of pharmacogenomic test results, and the complexity of interpreting results...
December 1, 2016: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/27863959/transmission-of-staphylococcus-aureus-between-health-care-workers-the-environment-and-patients-in-an-intensive-care-unit-a-longitudinal-cohort-study-based-on-whole-genome-sequencing
#12
James R Price, Kevin Cole, Andrew Bexley, Vasiliki Kostiou, David W Eyre, Tanya Golubchik, Daniel J Wilson, Derrick W Crook, A Sarah Walker, Timothy E A Peto, Martin J Llewelyn, John Paul
BACKGROUND: Health-care workers have been implicated in nosocomial outbreaks of Staphylococcus aureus, but the dearth of evidence from non-outbreak situations means that routine health-care worker screening and S aureus eradication are controversial. We aimed to determine how often S aureus is transmitted from health-care workers or the environment to patients in an intensive care unit (ICU) and a high-dependency unit (HDU) where standard infection control measures were in place. METHODS: In this longitudinal cohort study, we systematically sampled health-care workers, the environment, and patients over 14 months at the ICU and HDU of the Royal Sussex County Hospital, Brighton, England...
November 15, 2016: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/27857186/informatics-empowering-epatients-to-drive-health-care-reform
#13
Ramona Nelson
No abstract text is available yet for this article.
September 13, 2016: Online Journal of Issues in Nursing
https://www.readbyqxmd.com/read/27856010/increased-capture-of-pediatric-surgical-complications-utilizing-a-novel-case-log-web-application-to-enhance-quality-improvement
#14
Jason C Fisher, Keith A Kuenzler, Sandra S Tomita, Prashant Sinha, Paresh Shah, Howard B Ginsburg
PURPOSE: Documenting surgical complications is limited by multiple barriers and is not fostered in the electronic health record. Tracking complications is essential for quality improvement (QI) and required for board certification. Current registry platforms do not facilitate meaningful complication reporting. We developed a novel web application that improves accuracy and reduces barriers to documenting complications. METHODS: We deployed a custom web application that allows pediatric surgeons to maintain case logs...
October 28, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27854266/using-technology-bioinformatics-and-health-informatics-approaches-to-improve-learning-experiences-in-optometry-education-research-and-practice
#15
REVIEW
Vivek K Gupta, Veer B Gupta
Rapid advances in ocular diagnostic approaches and emerging links of pathological changes in the eye with systemic disorders have widened the scope of optometry as the front line of eye health care. Expanding professional requirements stipulate that optometry students get a meticulous training in relevant information and communication technologies (ICT) and various bioinformatics and health informatics software to meet current and future challenges. Greater incorporation of ICT approaches in optometry education can facilitate increased student engagement in shared learning experiences and improve collaborative learning...
November 15, 2016: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/27846827/nurses-perceptions-acceptance-and-use-of-a-novel-in-room-pediatric-icu-technology-testing-an-expanded-technology-acceptance-model
#16
Richard J Holden, Onur Asan, Erica M Wozniak, Kathryn E Flynn, Matthew C Scanlon
BACKGROUND: The value of health information technology (IT) ultimately depends on end users accepting and appropriately using it for patient care. This study examined pediatric intensive care unit nurses' perceptions, acceptance, and use of a novel health IT, the Large Customizable Interactive Monitor. METHODS: An expanded technology acceptance model was tested by applying stepwise linear regression to data from a standardized survey of 167 nurses. RESULTS: Nurses reported low-moderate ratings of the novel IT's ease of use and low to very low ratings of usefulness, social influence, and training...
November 15, 2016: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/27833560/pharmacometabolomics-informs-viromics-toward-precision-medicine
#17
Angeliki Balasopoulou, George P Patrinos, Theodora Katsila
Nowadays, we are experiencing the big data era with the emerging challenge of single data interpretation. Although the advent of high-throughput technologies as well as chemo- and bio-informatics tools presents pan-omics data as the way forward to precision medicine, personalized health care and tailored-made therapeutics can be only envisaged when interindividual variability in response to/toxicity of xenobiotics can be interpreted and thus, predicted. We know that such variability is the net outcome of genetics (host and microbiota) and environmental factors (diet, lifestyle, polypharmacy, and microbiota) and for this, tremendous efforts have been made to clarify key-molecules from correlation to causality to clinical significance...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27832780/public-responses-to-the-sharing-and-linkage-of-health-data-for-research-purposes-a-systematic-review-and-thematic-synthesis-of-qualitative-studies
#18
Mhairi Aitken, Jenna de St Jorre, Claudia Pagliari, Ruth Jepson, Sarah Cunningham-Burley
BACKGROUND: The past 10 years have witnessed a significant growth in sharing of health data for secondary uses. Alongside this there has been growing interest in the public acceptability of data sharing and data linkage practices. Public acceptance is recognised as crucial for ensuring the legitimacy of current practices and systems of governance. Given the growing international interest in this area this systematic review and thematic synthesis represents a timely review of current evidence...
November 10, 2016: BMC Medical Ethics
https://www.readbyqxmd.com/read/27830261/nursing-informatics-certification-worldwide-history-pathway-roles-and-motivation
#19
Mollie R Cummins, Adi V Gundlapalli, Aditya V Gundlapalli, Peter Murray, Hyeoun-Ae Park, Christoph U Lehmann
INTRODUCTION: Official recognition and certification for informatics professionals are essential aspects of workforce development. OBJECTIVE: To describe the history, pathways, and nuances of certification in nursing informatics across the globe; compare and contrast those with board certification in clinical informatics for physicians. METHODS: (1) A review of the representative literature on informatics certification and related competencies for nurses and physicians, and relevant websites for nursing informatics associations and societies worldwide; (2) similarities and differences between certification processes for nurses and physicians, and (3) perspectives on roles for nursing informatics professionals in healthcare Results: The literature search for 'nursing informatics certification' yielded few results in PubMed; Google Scholar yielded a large number of citations that extended to magazines and other non-peer reviewed sources...
November 10, 2016: Yearbook of Medical Informatics
https://www.readbyqxmd.com/read/27830258/some-innovative-approaches-for-public-health-and-epidemiology-informatics
#20
L Toubiana, N Griffon
OBJECTIVES: Summarize excellent current research published in 2015 in the field of Public Health and Epidemiology Informatics. METHODS: The complete 2015 literature concerning public health and epidemiology informatics has been searched in PubMed and Web of Science, and the returned references were reviewed by the two section editors to select 14 candidate best papers. These papers were then peer-reviewed by external reviewers to allow the editorial team an enlightened selection of the best papers...
November 10, 2016: Yearbook of Medical Informatics
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