keyword
https://read.qxmd.com/read/37536911/multidisciplinary-consensus-document-on-the-management-of-massive-haemorrhage-first-update-2023-document-hemomas-ii
#1
Juan V Llau, César Aldecoa, Emilia Guasch, Pascual Marco, Pilar Marcos-Neira, Pilar Paniagua, José A Páramo, Manuel Quintana, F Javier Rodríguez-Martorell, Ainhoa Serrano
This document is an update of the multidisciplinary document HEMOMAS, published in 2016 with the endorsement of the Spanish Scientific Societies of Anaesthesiology (SEDAR), Intensive Care (SEMICYUC) and Thrombosis and Haemostasis (SETH). The aim of this document was to review and update existing recommendations on the management of massive haemorrhage. The methodology of the update was based on several elements of the ADAPTE method by searching and adapting guidelines published in the specific field of massive bleeding since 2014, plus a literature search performed in PubMed and EMBASE from January 2014 to June 2021...
August 2023: Medicina intensiva
https://read.qxmd.com/read/37352590/supraglottoplasty-for-severe-laryngomalacia-can-be-effective-and-safe-also-in-children-with-high-risk-comorbidities-experience-from-a-tertiary-center
#2
JOURNAL ARTICLE
Gabriel Medin, Malin Wendt, Andreas Ekborn, Andreas Andersson, Caroline Gahm
OBJECTIVES: Supraglottoplasty (SGP) for severe laryngomalacia (LM) in children with medical comorbidities has been associated with high risk of surgical failure and increased need of postoperative pediatric intensive care unit (PICU) intervention, but evidence for this is ambiguous. The objective was to evaluate surgical outcome and risk of need for PICU-intervention following SGP for severe LM in comorbid patients. METHODS: Retrospective observational study of 116 patients treated with SGP for severe LM between 2000 and 2021 at a tertial referral pediatric airway surgery center Karolinska University Hospital...
August 2023: International Journal of Pediatric Otorhinolaryngology
https://read.qxmd.com/read/36272909/fluid-responsiveness-assessment-using-inferior-vena-cava-collapsibility-among-spontaneously-breathing-patients-systematic-review-and-meta-analysis
#3
JOURNAL ARTICLE
L C M Cardozo Júnior, G S D Lemos, B A M P Besen
OBJECTIVE: To synthesize the evidence about diagnostic accuracy of inferior vena cava collapsibility (IVCc) in prediction of fluid responsiveness among spontaneously breathing patients. DESIGN: Systematic review of diagnostic accuracy studies. SETTING: Intensive care units or emergency departments. PATIENTS AND PARTICIPANTS: spontaneously breathing patients with indication for fluid bolus administration. INTERVENTIONS: A search was conducted in MEDLINE and EMBASE...
October 19, 2022: Medicina intensiva
https://read.qxmd.com/read/36243630/peep-titration-by-eit-strategies-for-patients-with-ards-a-systematic-review-and-meta-analysis
#4
JOURNAL ARTICLE
Mengnan Yu, Yanjun Deng, Jun Cha, Lingyan Jiang, Mingdeng Wang, Shigang Qiao, Chen Wang
OBJECTIVE: To determine which method of Positive End-expiratory Pressure (PEEP) titration is more useful, and to establish an evidence base for the clinical impact of Electrical Impedance Tomography (EIT) based individual PEEP setting which appears to be a promising method to optimize PEEP in Acute Respiratory Distress Syndrome (ARDS) patients. DESIGN: A systematic review and meta-analysis. SETTING: 4 databases (PUBMED, EMBASE, Web Of Science, and the Cochrane Library) from 1980 to December 2020 were performed...
July 2023: Medicina intensiva
https://read.qxmd.com/read/36057440/competency-assessment-of-residents-of-intensive-care-medicine-through-a-simulation-based-objective-structured-clinical-evaluation-osce-a-multicenter-observational-study
#5
JOURNAL ARTICLE
Á Castellanos-Ortega, M J Broch, D Palacios-Castañeda, V Gómez-Tello, M Valdivia, C Vicent, I Madrid, N Martinez, M J Párraga, E Sancho, M D C Fuentes-Dura, M D Sancerni-Beitia, R García-Ros
OBJECTIVES: The current official model of training in Intensive Care Medicine (ICM) in Spain is based on exposure to experiences through clinical rotations. The main objective was to determine the level of competency (I novice to V independent practitioner) achieved by the residents at the end of the 3rd year of training (R3) in ICM through a simulation-based OSCE. Secondary objectives were: (1) To identify gaps in performance, and (2) To investigate the reliability and feasibility of conducting simulation-based assessment at multiple sites...
September 2022: Medicina intensiva
https://read.qxmd.com/read/35970706/a-guide-to-selecting-flexible-survival-models-to-inform-economic-evaluations-of-cancer-immunotherapies
#6
JOURNAL ARTICLE
Stephen Palmer, Isabelle Borget, Tim Friede, Don Husereau, Jonathan Karnon, Ben Kearns, Emma Medin, Elisabeth F P Peterse, Sven L Klijn, Elisabeth J M Verburg-Baltussen, Elisabeth Fenwick, John Borrill
OBJECTIVES: Parametric models are routinely used to estimate the benefit of cancer drugs beyond trial follow-up. The advent of immune checkpoint inhibitors has challenged this paradigm, and emerging evidence suggests that more flexible survival models, which can better capture the shapes of complex hazard functions, might be needed for these interventions. Nevertheless, there is a need for an algorithm to help analysts decide whether flexible models are required and, if so, which should be chosen for testing...
August 13, 2022: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://read.qxmd.com/read/34563341/acceptance-and-validity-of-the-methods-used-to-implement-a-competency-based-medical-education-programme-in-an-intensive-care-department-of-a-teaching-referral-center
#7
JOURNAL ARTICLE
A Castellanos-Ortega, M J Broch, M Barrios, M C Fuentes-Dura, M D Sancerni-Beitia, C Vicent, R Gimeno, P Ramírez, F Pérez, R García-Ros
OBJECTIVES: 1. To determine the satisfaction of tutors and residents with a specific methodology used to implement CoBaTrICE. 2. To determine the reliability and validity of the global rating scales designed ad hoc to assess the performance of the residents for training purposes. DESIGN: Prospective cohort study. PARTICIPANTS: All the residents and tutors of the ICU Department of the Hospital Universitario y Politécnico la Fe de Valencia...
October 2021: Medicina intensiva
https://read.qxmd.com/read/34249352/methods-and-rationale-of-the-discover-ckd-global-observational-study
#8
JOURNAL ARTICLE
Roberto Pecoits-Filho, Glen James, Juan Jesus Carrero, Eric Wittbrodt, Steven Fishbane, Alyshah Abdul Sultan, Hiddo J L Heerspink, Katarina Hedman, Eiichiro Kanda, Hungta Tony Chen, Naoki Kashihara, James Sloand, Mikhail Kosiborod, Supriya Kumar, Mitja Lainscak, Matthew Arnold, Carolyn S P Lam, Björn Holmqvist, Carol Pollock, Peter Fenici, Peter Stenvinkel, Jennie Medin, David C Wheeler
BACKGROUND: Real-world data for patients with chronic kidney disease (CKD), specifically pertaining to clinical management, metabolic control, treatment patterns, quality of life (QoL) and dietary patterns, are limited. Understanding these gaps using real-world, routine care data will improve our understanding of the challenges and consequences faced by patients with CKD, and will facilitate the long-term goal of improving their management and prognosis. METHODS: DISCOVER CKD follows an enriched hybrid study design, with both retrospective and prospective patient cohorts, integrating primary and secondary data from patients with CKD from China, Italy, Japan, Sweden, the UK and the USA...
June 2021: Clinical Kidney Journal
https://read.qxmd.com/read/34120787/effects-of-sodium-bicarbonate-infusion-on-mortality-in-medical-surgical-icu-patients-with-metabolic-acidosis-a-single-center-propensity-score-matched-analysis
#9
JOURNAL ARTICLE
J Waskowski, B Hess, L Cioccari, I Irincheeva, C A Pfortmueller, J C Schefold
OBJECTIVE: Metabolic acidosis is associated with high mortality. Despite theoretical benefits of sodium-bicarbonate (SB), current evidence remains controversial. We investigated SB-related effects on outcomes in ICU patients with metabolic acidosis. DESIGN: Retrospective analysis. SETTING: Academic medical center. PATIENTS OR PARTICIPANTS: 971 ICU patients with metabolic acidosis defined as arterial pH<7.3 and CO2 <45mmHg treated between 2012 and 2016...
June 10, 2021: Medicina intensiva
https://read.qxmd.com/read/34059220/summary-of-recommendations-and-key-points-of-the-consensus-of-spanish-scientific-societies-separ-semicyuc-semes-secip-seneo-sedar-senp-on-the-use-of-non-invasive-ventilation-and-high-flow-oxygen-therapy-with-nasal-cannulas-in-adult-pediatric-and-neonatal-patients
#10
M Luján, Ó Peñuelas, C Cinesi Gómez, A García-Salido, J Moreno Hernando, A Romero Berrocal, I Gutiérrez Ibarluzea, J F Masa Jiménez, A Mas, J M Carratalá Perales, M Gaboli, A Concheiro Guisán, J García Fernández, J Escámez, J Parrilla Parrilla, E Farrero Muñoz, M González, S B Heili-Frades, M Á Sánchez Quiroga, G Rialp Cervera, G Hernández, A Sánchez Torres, R Uña, C F Ortolà, M Ferrer Monreal, C Egea Santaolalla
Non-invasive respiratory support (NIRS) in adult, pediatric, and neonatal patients with acute respiratory failure (ARF) comprises two treatment modalities, non-invasive mechanical ventilation (NIMV) and high-flow nasal cannula (HFNC) therapy. However, experts from different specialties disagree on the benefit of these techniques in different clinical settings. The objective of this consensus was to develop a series of good clinical practice recommendations for the application of non-invasive support in patients with ARF, endorsed by all scientific societies involved in the management of adult and pediatric/neonatal patients with ARF...
2021: Medicina intensiva
https://read.qxmd.com/read/33710522/the-potential-effect-mechanism-of-high-fat-and-high-carbohydrate-diet-induced-obesity-on-anxiety-and-offspring-of-zebrafish
#11
JOURNAL ARTICLE
Medine Türkoğlu, Alper Baran, Ekrem Sulukan, Atena Ghosigharehagaji, Serkan Yildirim, Hacer Akgül Ceyhun, İsmail Bolat, Murat Arslan, Saltuk Buğrahan Ceyhun
Anxiety and obesity are two current phenomena. They are among the important public health problems with increasing prevalence worldwide. Although it is claimed that there are strong relations between them, the mechanism of this relationship has not been fully clarified yet. On the other hand, the effect of this relationship on the offspring has been another research subject. In this study, obese zebrafish were obtained by feeding two different diets, one containing high amount of lipid (HF) and the other containing high amount of carbohydrate (HK), and their anxiety levels were evaluated...
February 2022: Eating and Weight Disorders: EWD
https://read.qxmd.com/read/33578223/climate-change-and-epilepsy-insights-from-clinical-and-basic-science-studies
#12
REVIEW
Medine I Gulcebi, Emanuele Bartolini, Omay Lee, Christos Panagiotis Lisgaras, Filiz Onat, Janet Mifsud, Pasquale Striano, Annamaria Vezzani, Michael S Hildebrand, Diego Jimenez-Jimenez, Larry Junck, David Lewis-Smith, Ingrid E Scheffer, Roland D Thijs, Sameer M Zuberi, Stephen Blenkinsop, Hayley J Fowler, Aideen Foley, Sanjay M Sisodiya
Climate change is with us. As professionals who place value on evidence-based practice, climate change is something we cannot ignore. The current pandemic of the novel coronavirus, SARS-CoV-2, has demonstrated how global crises can arise suddenly and have a significant impact on public health. Global warming, a chronic process punctuated by acute episodes of extreme weather events, is an insidious global health crisis needing at least as much attention. Many neurological diseases are complex chronic conditions influenced at many levels by changes in the environment...
March 2021: Epilepsy & Behavior: E&B
https://read.qxmd.com/read/33309463/summary-of-recommendations-and-key-points-of-the-consensus-of-spanish-scientific-societies-separ-semicyuc-semes-secip-seneo-sedar-senp-on-the-use-of-non-invasive-ventilation-and-high-flow-oxygen-therapy-with-nasal-cannulas-in-adult-pediatric-and-neonatal-patients
#13
M Luján, Ó Peñuelas, C Cinesi Gómez, A García-Salido, J Moreno Hernando, A Romero Berrocal, I Gutiérrez Ibarluzea, J F Masa Jiménez, A Mas, J M Carratalá Perales, M Gaboli, A Concheiro Guisán, J García Fernández, J Escámez, J Parrilla Parrilla, E Farrero Muñoz, M González, S B Heili-Frades, M Á Sánchez Quiroga, G Rialp Cervera, G Hernández, A Sánchez Torres, R Uña, C F Ortolà, M Ferrer Monreal, C Egea Santaolalla
Non-invasive respiratory support (NIRS) in adult, pediatric, and neonatal patients with acute respiratory failure (ARF) comprises two treatment modalities, non-invasive mechanical ventilation (NIMV) and high-flow nasal cannula (HFNC) therapy. However, experts from different specialties disagree on the benefit of these techniques in different clinical settings. The objective of this consensus was to develop a series of good clinical practice recommendations for the application of non-invasive support in patients with ARF, endorsed by all scientific societies involved in the management of adult and pediatric/neonatal patients with ARF...
June 2021: Medicina intensiva
https://read.qxmd.com/read/31780699/the-bears-from-dmanisi-and-the-first-dispersal-of-early-homo-out-of-africa
#14
JOURNAL ARTICLE
Tsegai Medin, Bienvenido Martínez-Navarro, Joan Madurell-Malapeira, Borja Figueirido, Giorgi Kopaliani, Florent Rivals, Gocha Kiladze, Paul Palmqvist, David Lordkipanidze
We report on the taxonomy and paleodiet of the bear population that inhabited the emblematic palaeoanthropological Early Pleistocene (1.8 Ma) site of Dmanisi (Georgia), based on a dual approach combining morphometrics and microwear of upper and lower teeth. Given that the teeth of Ursus etruscus Cuvier, 1823 from Dmanisi show considerable size variability, their systematic position has been debated. However, a comparative study of the coefficients of variation for tooth size measurements in several modern bear species shows that the variability in tooth size of the ursid population from Dmanisi could result from sexual dimorphism...
November 28, 2019: Scientific Reports
https://read.qxmd.com/read/31132729/sleep-as-a-topic-in-nursing-education-programs-a-mixed-method-study-of-syllabuses-and-nursing-students-perceptions
#15
JOURNAL ARTICLE
Linda Gellerstedt, Jörgen Medin, Maria Kumlin, Monica Rydell Karlsson
BACKGROUND: Sleep is a basic human need and is considered important for maintaining health. It is even more important during illness due to its impact for example on our immune system. Nurses have an important role in identifying sleep deprivation. They are also in a unique position to promote and address sleep among patients. However, it is essential that they are provided with the appropriate knowledge during training. AIM: To explore and describe nursing students' perceptions of preparedness to adress and support patients' sleep during hospitalization and to apply sleep-promoting interventions in a clinical context...
August 2019: Nurse Education Today
https://read.qxmd.com/read/31128082/inherited-monogenic-defects-of-ceramide-metabolism-molecular-bases-and-diagnoses
#16
REVIEW
Patricia Dubot, Frédérique Sabourdy, Jitka Rybova, Jeffrey A Medin, Thierry Levade
Ceramides are membrane lipids implicated in the regulation of numerous biological functions. Recent evidence suggests that specific subsets of molecular species of ceramide may play distinct physiological roles. The importance of this family of molecules in vertebrates is witnessed by the deleterious consequences of genetic alterations in ceramide metabolism. This brief review summarizes the clinical presentation of human disorders due to the deficiency of enzymes involved either in the biosynthesis or the degradation of ceramides...
May 22, 2019: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://read.qxmd.com/read/29702990/traditional-cardiovascular-risk-factors-and-coronary-collateral-circulation-protocol-for-a-systematic-review-and-meta-analysis-of-case-control-studies
#17
JOURNAL ARTICLE
Zhenhua Xing, Junyu Pei, Liang Tang, Xinqun Hu
BACKGROUND: Well-developed coronary collateral circulation usually results in fewer infarct size, improved cardiac function, and fewer mortality. Traditional coronary risk factors (diabetes, hypertension, and smoking) have some effects on coronary collateral circulation. However, the association between these risk factors and coronary collateral circulation are controversial. Given the confusing evidences regarding traditional cardiovascular risk factors on coronary collateral circulation, we performed this meta-analysis protocol to investigate the relationship between traditional risk factors of coronary artery disease and coronary collateral circulation...
April 2018: Medicine (Baltimore)
https://read.qxmd.com/read/28866608/medical-research-and-audit-skills-training-for-undergraduates-an-international-analysis-and-student-focused-needs-assessment
#18
JOURNAL ARTICLE
(no author information available yet)
INTRODUCTION: Interpreting, performing and applying research is a key part of evidence-based medical practice, however, incorporating these within curricula is challenging. This study aimed to explore current provision of research skills training within medical school curricula, provide a student-focused needs assessment and prioritise research competencies. METHODS: A international, cross-sectional survey of final year UK and Irish medical students was disseminated at each participating university...
January 2018: Postgraduate Medical Journal
https://read.qxmd.com/read/28621808/primary-care-interventions-to-reduce-childhood-obesity-and-sugar-sweetened-beverage-consumption-food-for-thought-for-oral-health-professionals
#19
REVIEW
Diane Dooley, Nicolette M Moultrie, Elsbeth Sites, Patricia B Crawford
OBJECTIVES: Childhood obesity remains a significant threat to America's children. Health care leaders have increasingly called upon oral health professionals to integrate healthy weight promotion and enhanced sugar-sweetened beverage counseling into their professional practices. The aim of this scoping review is to examine recent evidence regarding the effectiveness of primary care childhood obesity interventions that have potential for adoption by oral health professionals. METHODS: Medine, and PubMed were searched from 2010 to 2016 for review articles and studies reporting patient outcomes or policy outcomes relevant to primary care childhood obesity interventions for children ages 2-11 years...
June 2017: Journal of Public Health Dentistry
https://read.qxmd.com/read/28212923/multiple-sclerosis-in-the-real-world-a-systematic-review-of-fingolimod-as-a-case-study
#20
REVIEW
Tjalf Ziemssen, Jennie Medin, C Anne-Marie Couto, Catherine R Mitchell
INTRODUCTION: The aim of our study was to systematically review the growing body of published literature reporting on one specific multiple sclerosis (MS) treatment, fingolimod, in the real world to assess its effectiveness in patients with MS, evaluate methodologies used to investigate MS in clinical practice, and describe the evidence gaps for MS as exemplified by fingolimod. METHODS: We conducted a PRISMA-compliant systematic review of the literature (cut-off date: 4 March 2016)...
April 2017: Autoimmunity Reviews
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