keyword
MENU ▼
Read by QxMD icon Read
search

physiology of aging

keyword
https://www.readbyqxmd.com/read/28941386/trp64arg-polymorphism-of-the-adrb3-gene-associated-with-maximal-fat-oxidation-and-ldl-c-levels-in-non-obese-adolescents
#1
Íncare Correa de Jesus, Lupe Furtado Alle, Eva Cantalejo Munhoz, Larissa Rosa da Silva, Wendell Arthur Lopes, Luciane Viater Tureck, Katia Sheylla Malta Purim, Ana Claudia Kapp Titski, Neiva Leite
OBJECTIVE: To analyze the association between the Trp64Arg polymorphism of the ADRB3 gene, maximal fat oxidation rates (FATMAX) and the lipid profile levels in non-obese adolescents. METHODS: 72 schoolchildren, of both genders, aged between 11 and 17 years, participated in the study. The anthropometric and body composition variables, in addition to total cholesterol (TC), high density lipoprotein (HDL-c), low density lipoprotein (LDL-c), triglycerides (TG), insulin (INS), and basal glycemia (GLIC), were evaluated...
September 20, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/28938771/comparative-estimation-of-inevitable-endogenous-ileal-flow-of-amino-acids-in-pekin-ducks-under-varying-dietary-or-physiological-conditions-and-their-significance-to-nutritional-requirements-for-amino-acids
#2
D O Akinde
In 2 experiments in Pekin ducks the inevitable endogenous ileal flow (IEIF) of AA was estimated at changing intake and source of crude fiber (CF) or soybean oil (SO) level. Also the roles of dry matter intake (DMI) and BW or age as well as the proportion of IEIF in the dietary requirement for AA were studied. In experiment 1 three basal CP (20, 60, or 100 g/kg) diets were formulated containing a low CF (LCF, 30 g/kg) or high (HCF, 80 g/kg) level; achieved with cellulose supplementation. All diets were similar in every other respect including having SO content of 40 g/kg...
October 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/28938749/the-testicular-transcriptome-associated-with-spermatogonia-differentiation-initiated-by-gonadotrophin-stimulation-in-the-juvenile-rhesus-monkey-macaca-mulatta
#3
Suresh Ramaswamy, William H Walker, Paula Aliberti, Rahil Sethi, Gary R Marshall, Alyxzandria Smith, Seyedmehdi Nourashrafeddin, Alicia Belgorosky, Uma R Chandran, Mark P Hedger, Tony M Plant
STUDY QUESTION: What is the genetic landscape within the testis of the juvenile rhesus monkey (Macaca mulatta) that underlies the decision of undifferentiated spermatogonia to commit to a pathway of differentiation when puberty is induced prematurely by exogenous LH and FSH stimulation? SUMMARY ANSWER: Forty-eight hours of gonadotrophin stimulation of the juvenile monkey testis resulted in the appearance of differentiating B spermatogonia and the emergence of 1362 up-regulated and 225 down-regulated testicular mRNAs encoding a complex network of proteins ranging from enzymes regulating Leydig cell steroidogenesis to membrane receptors, and from juxtacrine and paracrine factors to transcriptional factors governing spermatogonial stem cell fate...
October 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28938473/the-role-of-episodic-postprandial-peptides-in-exercise-induced-compensatory-eating
#4
Catherine Gibbons, John E Blundell, Phillipa Caudwell, Dominic-Luc Webb, Per M Hellström, Erik Näslund, Graham Finlayson
Purpose: Prolonged physical activity gives rise to variable degrees of body weight and fat loss, and is associated with variability in appetite control (hunger and energy intake). Whether these effects are modulated by postprandial 'episodic' peptides is unclear. We examined the role of postprandial peptide response in compensatory eating during 12-weeks aerobic exercise and in response to high (HFLC) and low fat (LFHC) meals. Methods: 32 overweight/obese individuals - 16 completed 12-weeks aerobic exercise and 16 were age- and BMI-matched non-exercising controls...
August 18, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28938340/paediatric-traumatic-brain-injury-prognostic-insights-and-outlooks
#5
Alicia K Au, Robert S B Clark
PURPOSE OF REVIEW: Traumatic brain injury (TBI) is a leading cause of death and disability in children. Prognostication of outcome following TBI is challenging in this population and likely requires complex, multimodal models to achieve clinically relevant accuracy. This review highlights injury characteristics, physiological indicators, biomarkers and neuromonitoring modalities predictive of outcome that may be integrated for future development of sensitive and specific prognostic models...
September 21, 2017: Current Opinion in Neurology
https://www.readbyqxmd.com/read/28938100/exposure-to-phthalates-in-patients-with-diabetes-and-its-association-with-oxidative-stress-adiponectin-and-inflammatory-cytokines
#6
Yishuang Duan, Lei Wang, Liping Han, Bin Wang, Hongwen Sun, Liming Chen, Lingyan Zhu, Yi Luo
Epidemiologic studies have revealed higher concentrations of the metabolites of phthalic acid esters (mPAEs) in patients with type 2 diabetes. On the other hand, oxidative stress, adiponectin, and inflammatory cytokines play important roles in the pathogenesis of diabetes and its complications. However, little information is known about the association between exposure to PAEs and these physiological parameters. Hence, paired urine and blood samples were collected from a total of 329 volunteers, and 11 main mPAEs and malondialdehyde (MDA), as a biomarker of oxidative stress, were measured in the urine samples...
September 19, 2017: Environment International
https://www.readbyqxmd.com/read/28937256/evaluation-of-left-and-right-ventricular-systolic-and-diastolic-electromechanical-synchrony-in-older-people-a-population-based-observational-study
#7
R Laszlo, H Konz, K Kunz, D Dallmeier, J Klenk, M Denkinger, W Koenig, D Rothenbacher, J M Steinacker
It is unknown whether physiological ageing also goes along with electromechanical asynchrony of contraction. Aim of the study was to evaluate synchrony of contraction in older people with ("non-healthy") or without ("healthy") evidence for structural cardiac disease. In 547 persons (age 76.7+/-5.5 years, 306 male, 241 female) recruited from a population-based cohort of the ActiFE-Um study including a random sample of people >/= 65 years old living in the region of Ulm, Germany, various PW- and TDI-Doppler based markers for asynchrony were obtained by echocardiography...
September 22, 2017: Physiological Research
https://www.readbyqxmd.com/read/28937235/heart-rate-variability-in-newborns
#8
K Javorka, Z Lehotska, M Kozar, Z Uhrikova, B Kolarovszki, M Javorka, M Zibolen
Heart rate (HR) and heart rate variability (HRV) in newborns is influenced by genetic determinants, gestational and postnatal age, and other variables. Premature infants have a reduced HRV. In neonatal HRV evaluated by spectral analysis, a dominant activity can be found in low frequency (LF) band (combined parasympathetic and sympathetic component). During the first postnatal days the activity in the high frequency (HF) band (parasympathetic component) rises, together with an increase in LF band and total HRV...
September 22, 2017: Physiological Research
https://www.readbyqxmd.com/read/28937221/in-vivo-dissolution-and-systemic-absorption-of-immediate-release-ibuprofen-in-human-gastrointestinal-tract-under-fed-and-fasted-conditions
#9
Duxin Sun, Jason R Baker, Bo Wen, Ann Frances, Huixia Zhang, Alex Yu, Ting Zhao, Yasuhiro Tsume, Manjunath Pai, Barry Bleske, Xinyuan Zhang, R Lionberger, Allen Lee, Gordon Amidon, William L Hasler, Mark Koenigsknecht
PURPOSE: In vivo drug dissolution in the gastrointestinal (GI) tract is largely unmeasured. The purpose of this clinical study was to evaluate the in vivo drug dissolution and systemic absorption of the BCS Class IIa drug ibuprofen under fed and fasted conditions by direct sampling of stomach and small intestinal luminal content. Expanding current knowledge of drug dissolution in vivo will help to establish physiologically relevant in vitro models predictive of drug dissolution. METHODS: A multi-lumen GI catheter was orally inserted into the GI tract of healthy human subjects...
September 22, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28937038/factors-related-to-ventricular-size-and-valvular-regurgitation-in-healthy-tibetans-in-lhasa
#10
Ying Yang, Yun-Dai Chen, Bin Feng, Zha-Xi-Duo Ji, Wei Mao, Guang Zhi
BACKGROUND: Lhasa is the main residence of Tibetans and one of the highest cities in the world. Its unique geography and ethnic population provide the chance to investigate the interactions among high altitude, ethnicity, and cardiac adaptation. Meanwhile, echocardiographic data about healthy Tibetans on a large scale are not available. This study aimed to analyze physiological factors related to ventricular size and valvular function in healthy Tibetans in Lhasa. METHODS: A representative sample of residents in Tibet was recruited using a multistage cluster random sampling method...
October 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28936738/vascular-calcification-regulation-by-exosomes-in-the-vascular-wall
#11
Marcel Liberman, Luciana Cavalheiro Marti
Vascular calcification is a tightly regulated process that increases during ageing and occurs mainly in patients with diabetes and chronic renal failure. Exosomes are small membrane vesicles that are synthesized in a particular population of endosomes, also called multivesicular bodies, by inside budding into the lumen of the compartment. After fusion of exosome with the plasma membrane, these internal vesicles are secreted. Exosomes have a defined set of membrane and cytosolic proteins. The physiological function of exosomes is still a matter of debate...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28936596/age-related-behavioral-morphological-and-physiological-changes-in-the-hippocampus-of-zitter-rats
#12
Ayuka Ehara, Masao Maekawa, Yuuichi Hori, Kazuhiko Nakadate, Shiuchi Ueda
Convulsive seizure is known to be associated with hippocampal abnormalities, such as hilar cell degeneration, abnormal mossy fiber sprouting in the dentate gyrus (DG) and abnormal expression of immediate early genes. However, whether these morphological changes are a cause or consequence of convulsive seizures has remained contentious. Zitter (zi/zi) rats carry a mutation of the attractin gene and display spongiform degeneration of the brain. Spontaneous convulsive seizures in zi/zi rats over 8 months (M) old were demonstrated using 24-h video monitoring...
September 21, 2017: Anatomical Science International
https://www.readbyqxmd.com/read/28936066/cognitive-impairment-in-rural-elderly-population-in-ecuador
#13
Xavier Wong-Achi, Gabriela Egas, Dayana Cabrera
INTRODUCTION: The Mini-Cog is a simple and short test that identifies cognitive impairment. Its detection helps provide an early dementia diagnosis, rapid access to treatments, and even delay or reversion. MATERIALS AND METHODS: This multicenter, observational, descriptive, and cross-sectional study included 214 patients. Patients enrolled in this study were community dwellers aged ≥55-year-old, without prior diagnosis of cognitive impairment or dementia, with adequate hearing and vision functions...
August 2017: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/28935804/the-growth-pattern-of-neandertals-reconstructed-from-a-juvenile-skeleton-from-el-sidr%C3%A3-n-spain
#14
Antonio Rosas, Luis Ríos, Almudena Estalrrich, Helen Liversidge, Antonio García-Tabernero, Rosa Huguet, Hugo Cardoso, Markus Bastir, Carles Lalueza-Fox, Marco de la Rasilla, Christopher Dean
Ontogenetic studies help us understand the processes of evolutionary change. Previous studies on Neandertals have focused mainly on dental development and inferred an accelerated pace of general growth. We report on a juvenile partial skeleton (El Sidrón J1) preserving cranio-dental and postcranial remains. We used dental histology to estimate the age at death to be 7.7 years. Maturation of most elements fell within the expected range of modern humans at this age. The exceptions were the atlas and mid-thoracic vertebrae, which remained at the 5- to 6-year stage of development...
September 22, 2017: Science
https://www.readbyqxmd.com/read/28934640/continuous-longitudinal-infusion-of-rhigf-1-rhigfbp-3-in-extremely-preterm-infants-evaluation-of-feasibility-in-a-phase-ii-study
#15
Ingrid Hansen-Pupp, Ann Hellström, Mohamed Hamdani, Adina Tocoian, Nerissa C Kreher, David Ley, Boubou Hallberg
OBJECTIVE: To evaluate the feasibility of continuous longitudinal intravenous infusion of recombinant human insulin-like growth factor-1/recombinant human insulin-like growth factor binding protein-3 (rhIGF-1/rhIGFBP-3) for prevention of retinopathy of prematurity and other complications in extremely preterm infants (<28weeks' gestational age), based on initial sections of a phase II randomized controlled trial. DESIGN: The phase II trial was designed in four sections (A-D); we report pharmacokinetic and adverse events (AEs) data pooled for Sections B and C...
August 31, 2017: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/28934587/aging-in-the-cardiovascular-system-lessons-from-hutchinson-gilford-progeria-syndrome
#16
Magda R Hamczyk, Lara Del Campo, Vicente Andrés
Aging, the main risk factor for cardiovascular disease (CVD), is becoming progressively more prevalent in our societies. A better understanding of how aging promotes CVD is therefore urgently needed to develop new strategies to reduce disease burden. Atherosclerosis and heart failure contribute significantly to age-associated CVD-related morbimortality. CVD and aging are both accelerated in patients suffering from Hutchinson-Gilford progeria syndrome (HGPS), a rare genetic disorder caused by the prelamin A mutant progerin...
September 20, 2017: Annual Review of Physiology
https://www.readbyqxmd.com/read/28934530/intraindividual-increase-of-homeostatic-sleep-pressure-across-acute-and-chronic-sleep-loss-a-high-density-eeg-study
#17
Angelina Maric, Caroline Lustenberger, Esther Werth, Christian R Baumann, Rositsa Poryazova, Reto Huber
Study Objectives: To compare intraindividually the effects of acute sleep deprivation (ASD) and chronic sleep restriction (CSR) on the homeostatic increase in slow wave activity (SWA) and to relate it to impairments in basic cognitive functioning, that is, vigilance. Methods: The increase in SWA after ASD (40 hours of wakefulness) and after CSR (seven nights with time in bed restricted to 5 hours per night) relative to baseline sleep was assessed in nine healthy, male participants (age = 18-26 years) by high-density electroencephalography...
September 1, 2017: Sleep
https://www.readbyqxmd.com/read/28933808/pediatric-orthopedic-injuries-evidence-based-management-in-the-emergency-department-digest
#18
Jamie Lien, Kathryn H Pade
Upper and lower extremity injuries are common in children, with an overall risk of fracture estimated at just under 1 in 5 children. Pediatric bone anatomy and physiology produce age specific injury patterns and conditions that are unique to children, which can make accurate diagnosis difficult for emergency clinicians. This issue reviews the etiology and pathophysiology of child-specific fractures, as well as common injuries of the upper and lower extremities. Evidence-based recommendations for management of pediatric fractures, including appropriate diagnostic studies and treatment, are also discussed...
September 22, 2017: Pediatric Emergency Medicine Practice
https://www.readbyqxmd.com/read/28933715/rating-of-perceived-exertion-for-quantification-of-training-and-combat-loads-during-combat-sport-specific-activities-a-short-review
#19
Maamer Slimani, Philip Davis, Emerson Franchini, Wassim Moalla
Slimani, M, Davis, P, Franchini, E, and Moalla, W. Rating of perceived exertion for quantification of training and combat loads during combat sport-specific activities: a short review. J Strength Cond Res 31(10): 2889-2902, 2017-The aim of this short review was to summarize data pertaining to the rating of perceived exertion (RPE) methods (RPE value and session-RPE) during combat sport-specific activities (i.e., competition and training) based on many factors, including contest type (i.e., official vs. simulated vs...
October 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28933710/elite-youth-soccer-players-physiological-responses-time-motion-characteristics-and-game-performance-in-4-vs-4-small-sided-games-the-influence-of-coach-feedback
#20
Mirko Brandes, Sebastian Elvers
Brandes, M and Elvers, S. Elite youth soccer players' physiological responses, time-motion characteristics, and game performance in 4 vs. 4 small-sided games: the influence of coach feedback. J Strength Cond Res 31(10): 2652-2658, 2017-The purpose of this study was to determine the impact of mild vs. strongly pushed coach feedback on the physiological response, ratio of perceived exertion (RPE), and time-motion characteristics in soccer training with small-sided games (SSGs). Sixteen elite youth soccer players (aged 17...
October 2017: Journal of Strength and Conditioning Research
keyword
keyword
57520
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"