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physiology of aging

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https://www.readbyqxmd.com/read/29775876/childhood-abuse-and-depression-in-adulthood-the-mediating-role-of-allostatic-load
#1
Sandra Scheuer, Nicole Wiggert, Tanja Maria Brückl, Yvonne Awaloff, Manfred Uhr, Susanne Lucae, Stefan Kloiber, Florian Holsboer, Marcus Ising, Frank H Wilhelm
BACKGROUND: Traumatic experiences during childhood are considered a major risk factor for depression in adulthood. Childhood trauma may induce physiological dysregulation with long-term effects of increased allostatic load until adulthood, which may lead to depression. Thus, our aim was to investigate whether allostatic load - which represents a multi-system measure of physiological dysregulation - mediates the association between childhood trauma and adult depression. METHODS: The study sample consisted of 324 depressed inpatients participating in the Munich Antidepressant Response Signature (MARS) project and 261 mentally healthy control participants...
April 22, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29775421/probability-of-heat-intolerance-standardized-interpretation-of-heat-tolerance-testing-results-versus-specialist-judgment
#2
Haggai Schermann, Erin Craig, Einat Yanovich, Itay Ketko, Gary Kalmanovich, Ran Yanovich
CONTEXT:   The heat-tolerance test (HTT) is a screening tool for secondary prevention of exertional heat illness by the Israel Defense Forces. To discern participant tolerance, recruits are exposed to intermediate environmental and exercise stresses, and their physiological responses, core temperature, and heart rate are monitored. When their physiological measures rise at a higher rate or exceed the upper levels of absolute values compared with other participants, heat intolerance (HI) is diagnosed...
April 2018: Journal of Athletic Training
https://www.readbyqxmd.com/read/29775405/the-mouse-heart-attack-research-tool-mhart-1-0-database
#3
Kristine Y DeLeon-Pennell, Rugmani Padmanabhan Iyer, Yonggang Ma, Andriy Yabluchanskiy, Rogelio Zamilpa, Ying Ann Chiao, Presley Cannon, Courtney Cates, Elizabeth R Flynn, Ganesh V Halade, Lisandra E de Castro Bras, Merry L Lindsey
The generation of Big Data has enabled systems-level dissections into the mechanisms of cardiovascular pathology. Integration of genetic, proteomic, and pathophysiological variables across platforms and laboratories fosters discoveries through multidisciplinary investigations and minimizes unnecessary redundancy in research efforts. The Mouse Heart Attack Research Tool (mHART) consolidates a large dataset of over 10 years of experiments from a single laboratory for cardiovascular investigators to generate novel hypotheses and identify new predictive markers of progressive left ventricular remodeling following myocardial infarction (MI) in mice...
May 18, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29774990/searching-for-a-mitochondrial-root-to-the-decline-in-muscle-function-with-ageing
#4
EDITORIAL
Marta Gonzalez-Freire, Fatemeh Adelnia, Ruin Moaddel, Luigi Ferrucci
Sarcopenia, the age-related loss of muscle mass and strength, is linked to a range of adverse outcomes, such as impaired physical performance, cognitive function, and mortality. Preventing sarcopenia may reduce the burden of functional decline with aging and its impact on physiological and economic well-being in older adults. Mitochondria in muscle cells lose their intrinsic efficiency and capacity to produce energy during aging, and it has been hypothesized that such a decline is the main driver of sarcopenia...
May 18, 2018: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29774946/depression-and-perceived-social-support-among-saudi-patients-with-multiple-sclerosis
#5
Saba Hyarat, Ekhlas Al-Gamal, Ellaine Dela Rama
PURPOSE: To examine the association between depression level and perceived social support among patients with multiple sclerosis (MS) in Saudi Arabia. DESIGN AND METHODS: A cross-sectional, descriptive, correlational design was used with 140 patients. A self-reporting questionnaires were used. FINDINGS: The age range of the participants was 18-59 years (mean 34.3 years, SD 7.69). The mean score for reported depression was 27.5 which is considered as moderate level of depression...
May 18, 2018: Perspectives in Psychiatric Care
https://www.readbyqxmd.com/read/29774890/genetic-and-clinical-aspects-of-wolfram-syndrome-1-a-severe-neurodegenerative-disease
#6
REVIEW
Luciana Rigoli, Placido Bramanti, Chiara Di Bella, Filippo De Luca
Wolfram syndrome 1 (WS1) is a rare autosomal recessive neurodegenerative disease characterized by diabetes insipidus, diabetes mellitus, optic atrophy, deafness, and other abnormalities. WS1 usually results in death before the age of 50 years. The pathogenesis of WS1 is ascribed to mutations of human WFS1 gene on chromosome 4p encoding a transmembrane protein called wolframin which has physiological functions in membrane trafficking, secretion, processing, and/or regulation of ER calcium homeostasis. Different types of WFS1 mutations have been identified, and some of these have been associated with a dominant, severe type of WS...
May 2018: Pediatric Research
https://www.readbyqxmd.com/read/29774576/spatial-vision-in-older-adults-perceptual-changes-and-neural-bases
#7
REVIEW
Allison M McKendrick, Yu Man Chan, Bao N Nguyen
PURPOSE: The number of older adults is rapidly increasing internationally, leading to a significant increase in research on how healthy ageing impacts vision. Most clinical assessments of spatial vision involve simple detection (letter acuity, grating contrast sensitivity, perimetry). However, most natural visual environments are more spatially complicated, requiring contrast discrimination, and the delineation of object boundaries and contours, which are typically present on non-uniform backgrounds...
May 17, 2018: Ophthalmic & Physiological Optics: the Journal of the British College of Ophthalmic Opticians (Optometrists)
https://www.readbyqxmd.com/read/29774387/ultraviolet-radiation-induces-melan-a-expressing-cells-in-interfollicular-epidermis-in-wild-type-mice
#8
David A De Luca, Barbara Sterniczky, Susanne Kimeswenger, Dagmar Födinger, Agatha Schwarz, Thomas Schwarz, Christian Jantschitsch
Adult wild-type mice are not supposed to be proper models for ultraviolet radiation (UVR)-induced melanoma since melanocytes are confined to hair follicles and cannot be sufficiently reached by UVR. On the other hand, in mutated mouse models used for melanoma research limitations, including an altered immune system and selection of affected pathways, lead to tumors phenotypically quite different from naturally occurring melanomas. We compared the distribution of epidermal melanocytes in UVR and not-UVR-exposed wild-type C57BL/6 mice...
May 17, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29773684/when-fed-foods-with-similar-palatability-healthy-adult-dogs-and-cats-choose-different-macronutrient-compositions
#9
Jean A Hall, Jodi C Vondran, Melissa A Vanchina, Dennis E Jewell
Dogs and cats make short-term food choices based on palatability. We hypothesized that if palatability were masked, long-term food choices would be based on physiologic requirements, and circulating metabolite concentrations would reflect those choices. Four experimental foods with similar palatability, but varying in macronutrient composition, were prepared for healthy adult dogs (n=17) and cats (n=27). Food 1 was high protein; Food 2 was high fat; Food 3 was high carbohydrates; and Food 4 was balanced for macronutrients...
May 17, 2018: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29773513/insights-in-the-history-of-pancreas-restoring-the-true-meaning-of-kallikreas
#10
REVIEW
Niki Papavramidou
BACKGROUND/PURPOSE: This paper investigates the history of pancreas in classical and late antiquity with the intent to correlate it to the modern medical knowledge. Furthermore, an attempt is made to understand the true meaning of the term "kallikreas". METHODS: Only primary textual sources are used in the transcription of ancient references of "pancreas" and/or "kallikreas". All of the references are analyzed and interpreted under a modern prism for better understanding the ancient anatomy proposed...
May 4, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29773349/robot-assisted-training-using-hybrid-assistive-limb%C3%A2-for-cerebral-palsy
#11
Mayumi Matsuda, Nobuaki Iwasaki, Yuki Mataki, Hirotaka Mutsuzaki, Kenichi Yoshikawa, Kazushi Takahashi, Keiko Enomoto, Kumiko Sano, Aoi Kubota, Tomohiro Nakayama, Junko Nakayama, Haruka Ohguro, Masafumi Mizukami, Kazuhide Tomita
PURPOSE: The Hybrid Assistive Limb® (HAL®, CYBERDYNE) is a wearable robot that provides assistance to a patient while they are walking, standing, and performing leg movements based on the wearer's intended movement. The effect of robot-assisted training using HAL® for cerebral palsy (CP) is unknown. Therefore, we assessed the effect of robot-assisted training using HAL® on patients with CP, and compared walking and gross motor abilities between pre-intervention and post-intervention...
May 14, 2018: Brain & Development
https://www.readbyqxmd.com/read/29772353/cardiac-profile-of-chimeric-antigen-receptor-car-t-cell-therapy-in-children-a-single-institution-experience
#12
Danielle Burstein, Shannon Maude, Stephen Grupp, Heather Griffis, Joseph Rossano, Kimberly Lin
BACKGROUND: Immunotherapy with chimeric antigen receptor (CAR)-modified T-cells targeting CD19 for pediatric acute lymphoblastic leukemia (ALL) has demonstrated significant efficacy. The principle toxicity is cytokine release syndrome with resultant hypotension. However, the spectrum of cardiovascular effects associated with CAR T-cell therapy has not been systematically evaluated. METHODS: We reviewed all patients who received CD19-directed CAR T-cells at the Children's Hospital of Philadelphia between April 2012 and September 2016...
May 14, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29771944/intraocular-pressure-and-its-normal-range-adjusted-for-ocular-and-systemic-parameters-the-beijing-eye-study-2011
#13
Ya Xing Wang, Liang Xu, Wen Bin Wei, Jost B Jonas
PURPOSE: To examine the distribution of intraocular pressure (IOP) in a normal population and the associations of IOP with other ocular and systemic parameters. METHODS: Out of 3468 participants of the population-based cross-sectional Beijing Eye Study 2011 we selected those individuals without glaucomatous optic neuropathy. The study particpants underwent a detailed ophthalmologic and systemic examination. IOP was measured by air puff non-contact tonometry. RESULTS: The study included 3135 eyes of 3135 participants with a mean age of 64...
2018: PloS One
https://www.readbyqxmd.com/read/29771885/-selection-of-optimal-method-of-general-anesthesia-for-intubation-of-nasolacrimal-duct-in-young-children
#14
E A Bachinin, S I Utkin, E L Sorokin, D Iu Ignatenko, M V Stoliarov, R N Khalfin
PURPOSE: comparative assessment of safety and clinical efficacy of Sevoflurane and Halothane in general anesthesia for nasolacrimal duct intubation in children. MATERIAL AND METHODS: Clinical results of nasolacrimal duct intubation in 288 children with persistent obstruction of tear duct were analyzed. A newly developed method of general anesthesia in the supine position was used for all cases. General anesthetic Phthorothanum was used in 146 children; general anesthesia with Sevoflurane - in 142 children...
2018: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/29770872/application-of-the-aast-egs-grade-for-adhesive-small-bowel-obstruction-to-a-multi-national-patient-population
#15
Matthew C Hernandez, Arianna Birindelli, John L Bruce, Johannes J P Buitendag, Victory Y Kong, Mircea Beuran, Johnathon M Aho, Ionut Negoi, Damian L Clarke, Salomone Di Saverio, Martin D Zielinski
BACKGROUND: The American Association for the Surgery of Trauma (AAST) anatomic severity grading system for adhesive small bowel obstruction (ASBO) has demonstrated to be a valid tool in North American patient populations. Using a multi-national patient cohort, we retrospectively assessed the validity the AAST ASBO grading system and estimated disease severity in a global population in order to correlate with several key clinical outcomes. METHODS: Multicenter retrospective review during 2012-2016 from four centers, Minnesota USA, Bologna Italy, Pietermaritzburg South Africa, and Bucharest Romania, was performed...
May 16, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29770758/dietary-l-threonine-supplementation-attenuates-lipopolysaccharide-induced-inflammatory-responses-and-intestinal-barrier-damage-of-broiler-chickens-at-an-early-age
#16
Yueping Chen, Hao Zhang, Yefei Cheng, Yue Li, Chao Wen, Yanmin Zhou
This study was conducted to investigate the protective effects of l-threonine (l-Thr) supplementation on growth performance, inflammatory responses and intestinal barrier function of young broilers challenged with lipopolysaccharide (LPS). A total of 144 1-d-old male chicks were allocated to one of three treatments: non-challenged broilers fed a basal diet (control group), LPS-challenged broilers fed a basal diet without l-Thr supplementation and LPS-challenged broilers fed a basal diet supplemented with 3·0 g/kg l-Thr...
June 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29770745/2706-km-cycling-in-two-weeks-effects-on-cardiac-function-in-six-elderly-male-athletes
#17
Thomas Morville, Mads Rosenkilde, Nick Mattsson, Flemming Dela, Jørn W Helge, Hanne K Rasmusen
INTRODUCTION: Physiological effects of exercise on trained and untrained individuals have been studied extensively. Typically, young or middle-aged individuals are examined before and after short periods of vigorous exertion. METHODS: We studied six elderly male athletes (61±8 years (mean ± SD); baseline VO2 max 48±5 ml·kg-1 · min-1 ) with focus on cardiac function and biomarkers following 14 consecutive days of moderate intensity exercise. Cardiac dimensions, function, biomarkers, and other measures of cardiovascular health were examined at baseline and 2 and 28 h after the last day of cycling a total of 2706 km...
May 17, 2018: Physician and Sportsmedicine
https://www.readbyqxmd.com/read/29770316/preputialplasty-can-be-considered-an-alternative-to-circumcision-when-how-why-experience-of-italian-centre
#18
Rossella Angotti, Francesco Molinaro, Francesco Ferrara, Chiara Pellegrino, Edoardo Bindi, Giulia Fusi, Mario Messina
Background: Phimosis is a condition in which the foreskin cannot be portrayed on the glans. It is a physiological and common condition in the pediatric age. The pathological form derives from an inflammatory or traumatic lesion. Circumcision is the most common surgical treatment of phimosis but it is a controversial practice, especially in occidental world. Methods: We enrolled 61 patients with pathological phimosis (22/balanoposthitis, 18/painful erection, 21/urinary discomfort) between 2015-2017...
April 2018: Gland Surgery
https://www.readbyqxmd.com/read/29770299/regenerative-medicine-therapy-for-single-ventricle-congenital-heart-disease
#19
REVIEW
Chetan Ambastha, Gregory J Bittle, David Morales, Nathaniel Parchment, Progyaparamita Saha, Rachana Mishra, Sudhish Sharma, Alexander Vasilenko, Muthukumar Gunasekaran, Manal T Al-Suqi, Deqiang Li, Peixin Yang, Sunjay Kaushal
One of the most complex forms of congenital heart disease (CHD) involving single ventricle physiology is hypoplastic left heart syndrome (HLHS), characterized by underdevelopment of the left ventricle (LV), mitral and aortic valves, and narrowing of the ascending aorta. The underdeveloped LV is incapable of providing long-term systemic flow, and if left untreated, the condition is fatal. Current treatment for this condition consists of three consecutive staged palliative operations: the first is conducted within the first few weeks of birth, the second between 4 to 6 months, and the third and final surgery within the first 4 years...
April 2018: Translational Pediatrics
https://www.readbyqxmd.com/read/29770164/aquaporin-membrane-channels-in-oxidative-stress-cell-signaling-and-aging-recent-advances-and-research-trends
#20
REVIEW
Grazia Tamma, Giovanna Valenti, Elena Grossini, Sandra Donnini, Angela Marino, Raul A Marinelli, Giuseppe Calamita
Reactive oxygen species (ROS) are produced as a result of aerobic metabolism and as by-products through numerous physiological and biochemical processes. While ROS-dependent modifications are fundamental in transducing intracellular signals controlling pleiotropic functions, imbalanced ROS can cause oxidative damage, eventually leading to many chronic diseases. Moreover, increased ROS and reduced nitric oxide (NO) bioavailability are main key factors in dysfunctions underlying aging, frailty, hypertension, and atherosclerosis...
2018: Oxidative Medicine and Cellular Longevity
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