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https://www.readbyqxmd.com/read/28634618/ct-and-mri-findings-in-focal-eosinophilic-infiltration-of-the-liver
#1
Bao-Liang Guo, Qiu-Gen Hu, Fu-Sheng Ouyang, Bin Zhang, Yu-Hao Dong, Xiao-Ning Luo, Zhou-Yang Lian, Shui-Xing Zhang
OBJECTIVES: To investigate the findings of computed tomography (CT) and magnetic resonance imaging (MRI) of focal eosinophilic infiltration (FEI) of the liver. METHODS: A retrospective study including 29 patients with confirmed FEI of the liver was performed. We evaluated the lesions' number, distribution, size, shape, margin, attenuation or signal intensity characteristics, the enhancement pattern, and some special features. Spearman correlation analysis was used to analyze the correlation between the number of lesions and the eosinophil counts in peripheral blood...
June 20, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28627267/%C3%AE-cyclodextrin-based-ternary-complexes-of-haloperidol-and-organic-acids-the-effect-of-organic-acids-on-the-drug-solubility-enhancement
#2
Prisada Rakkaew, Jiraphong Suksiriworapong, Doungdaw Chantasart
Haloperidol (HALO) is a weak base with very low aqueous solubility that is used as an antipsychotic drug. This study aimed to improve its solubility by forming HALO/β-cyclodextrin (β-CD) based ternary complexes with organic acids. The solubility of HALO/β-CD binary and HALO/β-CD/organic acid ternary complexes in different media (i.e., citrate buffer pH 3 and 6) was explored. The stoichiometric ratio between the drug and β-CD was 1:1 in all complexes formed. The solubility of HALO/β-CD binary complexes significantly increased in citrate buffer pH 3 compared to citrate buffer pH 6...
June 19, 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/28621561/a-patent-review-of-two-fruitful-decades-1997-2016-of-isocoumarin-research
#3
Hidayat Hussain, Ivan R Green
Isocoumarins comprise a six-membered oxygen heterocycle (α-pyranone) along with one aromatic ring and are known to possess interesting biological properties. During the last two decade (1997-2016), isocoumarin chemistry has attracted attention due to its biological and pharmaceutical effects viz., anticancer, anti-diabetic, antibacterial, antimalarial, and fungicidal effects. Areas covered: This review covers the patents on the therapeutic activities of natural and synthetic isocoumarins over the last two decades (1997-2016)...
June 16, 2017: Expert Opinion on Therapeutic Patents
https://www.readbyqxmd.com/read/28604855/metal-free-formal-carbon-halogen-bond-insertion-facile-syntheses-of-3-halo-3-3-disubstituted-oxindoles-and-spirooxindole-%C3%AE-butyrolactones
#4
Rong Zhou, Rongfang Liu, Kai Zhang, Ling Han, Honghui Zhang, Wenchao Gao, Ruifeng Li
A novel P(NMe2)3-mediated formal carbon-halogen bond insertion of isatins into allylic and benzylic bromides/chlorides has been realized, leading to a facile synthesis of 3-halo 3,3'-disubstituted oxindoles. This reaction relies on the unique dual nucleophilic-electrophilic reactivity pattern of the Kukhtin-Ramirez adduct via a cascade SN2-SN2 process. It also represents a rare metal-free approach for carbon-halogen bond insertion. Upon treatment with trifluoroacetic acid, spirooxindole-γ-butyrolactones have been efficiently prepared from the corresponding insertion products...
June 22, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28604764/limited-nucleotide-pools-restrict-epstein-barr-virus-mediated-b-cell-immortalization
#5
A Y Hafez, J E Messinger, K McFadden, G Fenyofalvi, C N Shepard, G M Lenzi, B Kim, M A Luftig
Activation of cellular oncogenes as well as infection with tumor viruses can promote aberrant proliferation and activation of the host DNA damage response. Epstein-Barr virus (EBV) infection of primary human B cells induces a transient period of hyper-proliferation, but many of these infected cells succumb to an ataxia telangiectasia mutated/checkpoint kinase 2 (ATM/Chk2)-mediated senescence-like growth arrest. In this study, we assessed the role of DNA replicative stress and nucleotide pool levels in limiting EBV-infected B-cell outgrowth...
June 12, 2017: Oncogenesis
https://www.readbyqxmd.com/read/28599655/canine-reic-dkk-3-interacts-with-sgta-and-restores-androgen-receptor-signalling-in-androgen-independent-prostate-cancer-cell-lines
#6
Yuiko Kato, Kazuhiko Ochiai, Shota Kawakami, Nobuhiro Nakao, Daigo Azakami, Makoto Bonkobara, Masaki Michishita, Masami Morimatsu, Masami Watanabe, Toshinori Omi
BACKGROUND: The pathological condition of canine prostate cancer resembles that of human androgen-independent prostate cancer. Both canine and human androgen receptor (AR) signalling are inhibited by overexpression of the dimerized co-chaperone small glutamine-rich tetratricopeptide repeat-containing protein α (SGTA), which is considered to cause the development of androgen-independency. Reduced expression in immortalised cells (REIC/Dkk-3) interferes with SGTA dimerization and rescues AR signalling...
June 9, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28593385/tailor-made-management-of-thoracic-scoliosis-with-cervical-hyperextension-in-muscular-dystrophy
#7
A Angelliaume, L Harper, A Lalioui, A Delgove, Y Lefèvre
PURPOSE: We report the case of a 13-year-old boy managed for fixed cervical hyperextension due to congenital muscular dystrophy with partial merosin deficiency. He presented a right decompensated thoracic scoliosis (T6-L1 Cobb angle 72°) associated with cervical and lumbar lordosis. The spinal extension was accompanied by major flexion of the hip resulting in the trunk being bent forward. This posture caused daily severe back pain responsible for significant loss of quality of life. This led to the decision to perform surgery...
June 7, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28589067/intraoperative-dexmedetomidine-induced-polyuric-syndrome
#8
Shannon Granger, David Ninan
A 23-year-old male trauma patient with a cervical spine fracture underwent an anterior and posterior discectomy and spinal fusion surgery. The patient presented to the operating room with a stabilizing halo fixation device in place, and a fiberoptic intubation was performed with dexmedetomidine for sedation. During the surgical procedure, general anesthesia was maintained with a propofol and remifentanil infusion as the patient was monitored using somatosensory and motor evoked potentials. The patient's urine output increased gradually during the nine-hour surgical procedure from 150 mL/hour to over 700 mL/hour in the eighth hour of the procedure, where it remained until the end of the procedure...
May 3, 2017: Curēus
https://www.readbyqxmd.com/read/28586495/meta-analysis-of-the-fda-reports-on-patient-reported-outcomes-using-the-three-latest-platforms-for-lasik
#9
Majid Moshirfar, Tirth J Shah, David Franklin Skanchy, Steve H Linn, Daniel S Durrie
PURPOSE: To analyze the impact of the three latest U.S. Food and Drug Administration (FDA)-approved lasers on patient-reported outcomes after LASIK. METHODS: In this meta-analysis of patient-reported FDA data, an aggregated total of 718 eyes undergoing LASIK using VISX iDesign (Abbott Medical Optics Manufacturing, Milpitas, CA), Alcon Contoura (Alcon Research, Ltd., Fort Worth, TX), and Nidek CATz (Nidek Co. Ltd., Gamagori, Japan) lasers were evaluated for overall changes in visual symptoms postoperatively...
June 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28586349/comparison-of-the-induced-fields-using-different-coil-configurations-during-deep-transcranial-magnetic-stimulation
#10
Mai Lu, Shoogo Ueno
Stimulation of deeper brain structures by transcranial magnetic stimulation (TMS) plays a role in the study of reward and motivation mechanisms, which may be beneficial in the treatment of several neurological and psychiatric disorders. However, electric field distributions induced in the brain by deep transcranial magnetic stimulation (dTMS) are still unknown. In this paper, the double cone coil, H-coil and Halo-circular assembly (HCA) coil which have been proposed for dTMS have been numerically designed. The distributions of magnetic flux density, induced electric field in an anatomically based realistic head model by applying the dTMS coils were numerically calculated by the impedance method...
2017: PloS One
https://www.readbyqxmd.com/read/28580552/ability-of-t1-lipase-to-degrade-amorphous-p-3hb-structural-and-functional-study
#11
Rauda A Mohamed, Abu Bakar Salleh, Adam Thean Chor Leow, Normi M Yahaya, Mohd Basyaruddin Abdul Rahman
An enzyme with broad substrate specificity would be an asset for industrial application. T1 lipase apparently has the same active site residues as polyhydroxyalkanoates (PHA) depolymerase. Sequences of both enzymes were studied and compared, and a conserved lipase box pentapeptide region around the nucleophilic serine was detected. The alignment of 3-D structures for both enzymes showed their active site residues were well aligned with an RMSD value of 1.981 Å despite their sequence similarity of only 53...
June 3, 2017: Molecular Biotechnology
https://www.readbyqxmd.com/read/28580411/recurrent-halo-nevus-dermoscopy-and-confocal-microscopy-features
#12
Ana Carolina Porto, Tatiana Pinto Blumetti, Raquel de Paula Ramos Castro, Clovis Antônio Lopes Pinto, Adriana Silveira Pessoa Mendes, João Pedreira Duprat Neto, Gisele Gargantini Rezze, Juliana Casagrande Tavoloni Braga
No abstract text is available yet for this article.
May 2017: JAAD Case Reports
https://www.readbyqxmd.com/read/28574882/surgical-outcomes-of-posterior-spinal-fusion-alone-using-cervical-pedicle-screw-constructs-for-cervical-disorders-associated-with-athetoid-cerebral-palsy
#13
Kei Watanabe, Toru Hirano, Keiichi Katsumi, Masayuki Ohashi, Hirokazu Shoji, Akiyoshi Yamazaki, Tomohiro Izumi, Kazuhiro Hasegawa, Takui Ito, Naoto Endo
STUDY DESIGN: Retrospective case series. OBJECTIVE: To investigate clinical outcomes after posterior spinal fusion (PSF) using cervical pedicle screw (CPS) constructs for cervical disorders associated with athetoid cerebral palsy (CP). SUMMARY OF BACKGROUND DATA: Traditionally, most patients with cervical myelopathy associated with CP have required combined anterior and posterior fusion to achieve solid stability against severe involuntary movement...
June 1, 2017: Spine
https://www.readbyqxmd.com/read/28573166/halo-assay-for-toxic-peptides-and-other-compounds-in-microorganisms
#14
Houjian Cai, Melinda Hauser, Fred Naider, Jeffrey M Becker
We describe an assay for determination of toxicity in S. cerevisiae involving spotting of a toxic peptide on a lawn of yeast cells. This assay may be generalized to determine toxicity of a variety of compounds by substituting a putative toxic compound in place of the peptide. The general protocol may also be used to determine toxicity of any small compound toward another microorganism by replacing S. cerevisiae with the target microbe and modifying growth conditions accordingly. BACKGROUND: Di-/tripeptides are one of the major sources of nitrogen, carbon, and amino acids for all organisms...
November 20, 2016: Bio-protocol
https://www.readbyqxmd.com/read/28571974/effect-of-the-3-halo-substitution-of-the-2-deoxy-aminopyridinyl-pseudocytidine-derivatives-on-the-selectivity-and-stability-of-antiparallel-triplex-dna-with-a-cg-inversion-site
#15
Lei Wang, Yosuke Taniguchi, Hidenori Okamura, Shigeki Sasaki
Triplex formation against a target duplex DNA has the potential to become a tool for the genome research. However, there is an intrinsic restriction on the duplex DNA sequences capable of forming the triplex DNA. Recently, we demonstrated the selective formation of the stable antiparallel triplexes containing the CG inversion sites using the 2'-deoxy-1-methylpseudocytidine derivative (ΨdC), whose amino group was conjugated with the 2-aminopyridine at its 5-position as an additional hydrogen bonding unit (AP-ΨdC)...
May 19, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28570459/alar-pinning-in-rigid-external-distraction-for-midfacial-hypoplasia
#16
Jenny L Yu, Albert S Woo
BACKGROUND: Distraction osteogenesis with a rigid external distractor is a widely accepted treatment for midfacial hypoplasia. In this study, the authors introduce the utilization of alar pinning with the external halo distractor for maxillary advancement, in place of an oral splint. METHODS: A retrospective chart review was conducted of 7 patients who successfully underwent distraction osteogenesis using the alar pinning technique. Midfacial hypoplasia was secondary to Crouzon syndrome (n = 4), Apert syndrome (n = 1), Pfeiffer syndrome (n = 1), or bacterial meningitis (n = 1)...
May 31, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28561790/himatanthus-drasticus-leaves-chemical-characterization-and-evaluation-of-their-antimicrobial-antibiofilm-antiproliferative-activities
#17
Cristiane Santos Silva E Silva Figueiredo, Joice Castelo Branco Santos, José Artur de Aguiar Castro Junior, Vinícius Galvão Wakui, João F S Rodrigues, Mariana Oliveira Arruda, Andrea de Souza Monteiro, Valério Monteiro-Neto, Maria Rosa Quaresma Bomfim, Lucília Kato, Luís Cláudio Nascimento da Silva, Marcos Augusto Grigolin Grisotto
Plant-derived products have played a fundamental role in the development of new therapeutic agents. This study aimed to analyze antimicrobial, antibiofilm, cytotoxicity and antiproliferative potentials of the extract and fractions from leaves of Himatanthusdrasticus, a plant from the Apocynaceae family. After harvesting, H. drasticus leaves were macerated and a hydroalcoholic extract (HDHE) and fractions were prepared. Antimicrobial tests, such as agar-diffusion, Minimum Inhibitory Concentration (MIC) and Minimal Bactericidal Concentration (MBC) were carried out against several bacterial species...
May 31, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28558395/the-perception-of-hazy-gloss
#18
Peter Vangorp, Pascal Barla, Roland W Fleming
Most previous work on gloss perception has examined the strength and sharpness of specular reflections in simple bidirectional reflectance distribution functions (BRDFs) having a single specular component. However, BRDFs can be substantially more complex and it is interesting to ask how many additional perceptual dimensions there could be in the visual representation of surface reflectance qualities. To address this, we tested materials with two specular components that elicit an impression of hazy gloss. Stimuli were renderings of irregularly shaped objects under environment illumination, with either a single Ward specular BRDF component (Ward, 1992), or two such components, with the same total specular reflectance but different sharpness parameters, yielding both sharp and blurry highlights simultaneously...
May 1, 2017: Journal of Vision
https://www.readbyqxmd.com/read/28557281/aghalo-a-facile-fluorogenic-sensor-to-detect-drug-induced-proteome-stress
#19
Yu Liu, Matthew Fares, Noah P Dunham, Zi Gao, Kun Miao, Xueyuan Jiang, Samuel S Bollinger, Amie K Boal, Xin Zhang
Drug-induced proteome stress that involves protein aggregation may cause adverse effects and undermine the safety profile of a drug. Safety of drugs is regularly evaluated using cytotoxicity assays that measure cell death. However, these assays provide limited insights into the presence of proteome stress in live cells. A fluorogenic protein sensor is reported to detect drug-induced proteome stress prior to cell death. An aggregation prone Halo-tag mutant (AgHalo) was evolved to sense proteome stress through its aggregation...
May 29, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28557134/tgf%C3%AE-pathway-deregulation-and-abnormal-phospho-smad2-3-staining-in-hereditary-cerebral-hemorrhage-with-amyloidosis-dutch-type
#20
Laure Grand Moursel, Leon P Munting, Linda M van der Graaf, Sjoerd G van Duinen, Marie-Jose T H Goumans, Uwe Ueberham, Remco Natté, Mark A van Buchem, Willeke M C van Roon-Mom, Louise van der Weerd
Hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D) is an early onset hereditary form of cerebral amyloid angiopathy (CAA) pathology, caused by the E22Q mutation in the amyloid β (Aβ) peptide. Transforming Growth Factor β1 (TGFβ1) is a key player in vascular fibrosis and in the formation of angiopathic vessels in transgenic mice. Therefore we investigated whether the TGFβ pathway is involved in HCHWA-D pathogenesis in human postmortem brain tissue from frontal and occipital lobes. Components of the TGFβ pathway were analyzed with quantitative RT-PCR...
May 29, 2017: Brain Pathology
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