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https://www.readbyqxmd.com/read/28330184/potential-fibrinolytic-activity-of-an-endophytic-lasiodiplodia-pseudotheobromae-species
#1
Vineet Meshram, Sanjai Saxena
Cost-effective, fibrinolytic agents possessing least or no antigenic properties are much in demand for their prospective use as clot busters in thrombolytic therapy. The present communication explores the potential of 22 endophytic Botryosphaeria species isolated from stem of Aegle marmelos for their fibrinolytic potential. Only nine fungal isolates exhibited proteolytic activity out of which only four possessed plasminogen-independent fibrinolytic activity. The endophytic fungal isolate #1088 AMSTITYEL showed maximum in vitro proteolytic and fibrinolytic activity with a halo formation of 153...
June 2016: 3 Biotech
https://www.readbyqxmd.com/read/28329577/two-cases-of-halo-scalp-ring
#2
Thaer Hasan Douri
Halo scalp ring (HSR) is a rare form of non-scarring annular alopecia that is attributed to caput succedaneum. It arises perinatally because of prolonged pressure on the scalp by the cervix during or before the delivery. We report two new cases of halo scalp ring in full term pregnancy - newborns.
November 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28329517/purple-patches-in-an-immunocompromised-patient-a-report-of-secondary-disseminated-cutaneous-mucormycosis-in-a-man-with-chronic-lymphocytic-leukemia
#3
Sanjana Iyengar, Cindy J Chambers, Jillian W Millsop, Maxwell A Fung, Victoria R Sharon
A 60-year-old man with chronic lymphocytic leukemiadeveloped a deeply violaceous annular patchwith a halo of erythema on the right thigh duringhospitalization for neutropenic fever. Associatedsymptoms included chronic cough and fatigue.Bilateral lung opacities with hilar lymphadenopathywere noted on chest computed tomographyscan. Punch biopsy and tissue culture confirmeda diagnosis of secondary disseminated cutaneousmucormycosis. Although rare, physicians shouldinclude mucormycosis in the differential diagnosisof purpuric patches in immunosuppressed patients...
March 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28328103/characterization-of-maize-chitinase-a-a-tough-allergenic-molecule
#4
Mariateresa Volpicella, Claudia Leoni, Immacolata Fanizza, Marco Distaso, Guido Leoni, Laura Farioli, Todd Naumann, Elide Pastorello, Luigi Ruggiero Ceci
BACKGROUND: Food allergies are recognized as an increasing health concern. They are caused by specific proteins called food allergens. Proteins commonly identified as food allergens tend to have one of about 30 different biochemical activities. This leads to the assumption that food allergens must have specific structural features which causes their allergenicity. But these structural features are not completely understood. Uncovering the structural basis of allergenicity would allow improved diagnosis and therapy of allergies and would provide insights for safer food production...
March 22, 2017: Allergy
https://www.readbyqxmd.com/read/28321331/ct-patterns-of-organizing-pneumonia-in-patients-treated-with-vegf-mtor-inhibitors-for-metastatic-renal-cell-cancer-an-observational-study
#5
Sabine Dettmer, Viktor Grünwald, Thomas Fuehner, Arnold Ganser, Frank Wacker, Philipp Ivanyi, Thomas Rodt
BACKGROUND: Targeted therapies are the standard treatment in patients with metastatic renal cell carcinoma (mRCC) and are known to cause adverse pulmonary events. Organizing pneumonia (OP) with its various manifestations in computed tomography (CT) has therefore lately received more attention. PURPOSE: To describe the spectrum of CT patterns of OP in patients with mRCC receiving targeted therapies. MATERIAL AND METHODS: Seventeen patients with known therapy-related OP were analyzed retrospectively by two blinded radiologists in consensus...
February 2017: Acta Radiologica Open
https://www.readbyqxmd.com/read/28320645/interactive-exploration-of-cosmological-dark-matter-simulation-data
#6
Aaron Scherzinger, Tobias Brix, Dominik Drees, Andreas Volker, Kiril Radkov, Niko Santalidis, Alexander Fieguth, Klaus H Hinrichs
The winning entry of the 2015 IEEE Scientific Visualization Contest, this article describes a visualization tool for cosmological data resulting from dark-matter simulations. The proposed system helps users explore all aspects of the data at once and receive more detailed information about structures of interest at any time. Moreover, novel methods for visualizing and interactively exploring dark-matter halo substructures are proposed.
March 2017: IEEE Computer Graphics and Applications
https://www.readbyqxmd.com/read/28318888/characterization-of-the-lung-parenchyma-using-ultrasound-multiple-scattering
#7
Kaustav Mohanty, John Blackwell, Thomas Egan, Marie Muller
The purpose of the study described here was to showcase the application of ultrasound to quantitative characterization of the micro-architecture of the lung parenchyma to predict the extent of pulmonary edema. The lung parenchyma is a highly complex and diffusive medium for which ultrasound techniques have remained qualitative. The approach presented here is based on ultrasound multiple scattering and exploits the complexity of ultrasound propagation in the lung structure. The experimental setup consisted of a linear transducer array with an 8-MHz central frequency placed in contact with the lung surface...
March 16, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28317674/clinical-and-patient-reported-outcomes-of-bilateral-implantation-of-a-2-5-diopter-multifocal-intraocular-lens
#8
Andrew Maxwell, Edward Holland, Lisa Cibik, Anna Fakadej, Gary Foster, Les Grosinger, Andrew Moyes, Stephen Nielsen, Steven Silverstein, Melissa Toyos, Arthur Weinstein, Scott Hartzell
PURPOSE: To assess the effectiveness and safety of a multifocal intraocular lens (IOL) with +2.5 diopter (D) additional power compared with a monofocal IOL. SETTING: Fifteen sites in the United States. DESIGN: Prospective randomized patient- and observer-masked clinical trial. METHODS: Randomized patients received multifocal or monofocal IOLs bilaterally. Visual acuity (33 cm, 40 cm, 53 cm, 60 cm, 4 m) was measured; safety was assessed through adverse event rates...
January 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28317531/special-considerations-in-children-with-vitiligo
#9
REVIEW
Alain Taïeb, Julien Seneschal, Juliette Mazereeuw-Hautier
Childhood vitiligo differs from adult-onset vitiligo for several features including increased incidence of the segmental variant, higher prevalence of halo nevi, and more common family history for autoimmune diseases and atopic diathesis. The major differential diagnoses are the postinflammatory hypomelanoses for nonsegmental vitiligo and nevus depigmentosus for segmental vitiligo. From a therapeutic standpoint, early awareness of the diagnosis seems to correlate with a good treatment outcome in this age group...
April 2017: Dermatologic Clinics
https://www.readbyqxmd.com/read/28315427/histologic-features-of-stromogenic-carcinoma-of-the-prostate-carcinomas-with-reactive-stroma-grade-3
#10
Andrea Diaz De Vivar, Mohammad Sayeeduddin, David Rowley, Antonio Cubilla, Brian Miles, Dov Kadmon, Gustavo Ayala
Prostatic carcinoma, like many other carcinomas, generates a stromal reaction. This phenomenon is well established in the scientific literature. The normal parenchymal smooth muscle phenotype switches to a myofibroblastic phenotype in response to the presence of cancer cells, with an expansion of the extracellular matrix compartment. The amount of reactive stroma is a predictor of biochemical recurrence in both radical prostatectomies and biopsies. It is a predictor of prostate cancer specific death in prostatectomies...
March 14, 2017: Human Pathology
https://www.readbyqxmd.com/read/28314912/differences-in-the-melanosome-distribution-within-the-epidermal-melanin-units-and-its-association-with-the-impairing-background-of-leukoderma-in-vitiligo-and-halo-nevi-a-retrospective-study
#11
Xi-Xi Xiong, Gao-Zhong Ding, Wen-E Zhao, Xue Li, Yu-Ting Ling, Li Sun, Qing-Li Gong, Yan Lu
Skin color is determined by the number of melanin granules produced by melanocytes that are transferred to keratinocytes. Melanin synthesis and the distribution of melanosomes to keratinocytes within the epidermal melanin unit (EMU) within the skin of vitiligo patients have been poorly studied. The ultrastructure and distribution of melanosomes in melanocytes and surrounding keratinocytes in perilesional vitiligo and normal skin were investigated using transmission electron microscopy (TEM). Furthermore, we performed a quantitative analysis of melanosome distribution within the EMUs with scatter plot...
March 17, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28304114/antiviral-and-cytostatic-evaluation-of-5-1-halo-2-sulfonylvinyl-and-5-2-furyl-uracil-nucleosides
#12
Zhiwei Wen, Sazzad H Suzol, Jufang Peng, Yong Liang, Robert Snoeck, Graciela Andrei, Sandra Liekens, Stanislaw F Wnuk
Transition metal-catalyzed halosulfonylation of 5-ethynyl uracil nucleosides provided (E)-5-(1-chloro-2-tosylvinyl)uridines. Tetrabutylammonium fluoride-mediated direct CH arylation of 5-iodouracil nucleosides with furan or 2-heptylfuran gave 5-furyl-substituted nucleosides without the necessity of using the organometallic substrates. These two classes of 5-substituted uracil nucleosides as well their corresponding ester derivatives were tested against a broad range of DNA and RNA viruses and the human immunodeficiency virus (HIV)...
March 17, 2017: Archiv der Pharmazie
https://www.readbyqxmd.com/read/28300385/a-benchmarking-method-to-evaluate-the-accuracy-of-a-commercial-proton-monte-carlo-pencil-beam-scanning-treatment-planning-system
#13
Liyong Lin, Sheng Huang, Minglei Kang, Petri Hiltunen, Reynald Vanderstraeten, Jari Lindberg, Sami Siljamaki, Todd Wareing, Ian Davis, Allen Barnett, John McGhee, Charles B Simone, Timothy D Solberg, James E McDonough, Christopher Ainsley
AcurosPT is a Monte Carlo algorithm in the Eclipse 13.7 treatment planning system, which is designed to provide rapid and accurate dose calculations for proton therapy. Computational run-time in minimized by simplifying or eliminating less significant physics processes. In this article, the accuracy of AcurosPT was benchmarked against both measurement and an independent MC calculation, TOPAS. Such a method can be applied to any new MC calculation for the detection of potential inaccuracies. To validate multiple Coulomb scattering (MCS) which affects primary beam broadening, single spot profiles in a Solidwater(®) phantom were compared for beams of five selected proton energies between AcurosPT, measurement and TOPAS...
March 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28300118/strongly-baryon-dominated-disk-galaxies-at-the-peak-of-galaxy-formation-ten-billion-years-ago
#14
R Genzel, N M Förster Schreiber, H Übler, P Lang, T Naab, R Bender, L J Tacconi, E Wisnioski, S Wuyts, T Alexander, A Beifiori, S Belli, G Brammer, A Burkert, C M Carollo, J Chan, R Davies, M Fossati, A Galametz, S Genel, O Gerhard, D Lutz, J T Mendel, I Momcheva, E J Nelson, A Renzini, R Saglia, A Sternberg, S Tacchella, K Tadaki, D Wilman
In the cold dark matter cosmology, the baryonic components of galaxies-stars and gas-are thought to be mixed with and embedded in non-baryonic and non-relativistic dark matter, which dominates the total mass of the galaxy and its dark-matter halo. In the local (low-redshift) Universe, the mass of dark matter within a galactic disk increases with disk radius, becoming appreciable and then dominant in the outer, baryonic regions of the disks of star-forming galaxies. This results in rotation velocities of the visible matter within the disk that are constant or increasing with disk radius-a hallmark of the dark-matter model...
March 15, 2017: Nature
https://www.readbyqxmd.com/read/28293466/cadasil-ultrastructural-insights-into-the-morphology-of-granular-osmiophilic-material
#15
Teresa Lorenzi, Michele Ragno, Francesca Paolinelli, Clara Castellucci, Marina Scarpelli, Manrico Morroni
INTRODUCTION: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary systemic vascular disorder. Granular osmiophilic material (GOM) is its ultrastructural marker. We reviewed tissue biopsies from CADASIL patients to establish whether ultrastructural observations help clarify the pathogenic mechanism of CADASIL. Given the resemblance of the GOM deposits to the immunoglobulin deposits seen in glomerulonephritis and focal segmental glomerulosclerosis (FSGS), their morphologies were investigated and compared...
March 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28291147/strategies-for-surgical-management-of-large-stiff-spinal-deformities-in-children
#16
Kevin M Neal, Evan Siegall
Management of large, severe, stiff spinal deformities in children can be challenging. Adjunctive treatments used in conjunction with spinal osteotomy, instrumentation, and fusion can improve the ultimate degree of deformity correction. These adjunctive treatments include preoperative halo-gravity traction, intraoperative halo-femoral traction, temporary internal spinal distraction, and anterior spinal release. Each of these techniques has unique indications and individual risks. When the appropriate protocols are followed, these techniques can be safe and efficacious...
April 2017: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/28286943/correction-to-diastereoselective-organocatalytic-addition-of-%C3%AE-angelica-lactone-to-%C3%AE-halo-%C3%AE-ketoesters
#17
Jessica A Griswold, Matthew A Horwitz, Leslie V Leiva, Jeffrey S Johnson
No abstract text is available yet for this article.
March 13, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28271538/the-lack-of-relation-between-straylight-and-visual-acuity-two-domains-of-the-point-spread-function
#18
Thomas J T P van den Berg
PURPOSE: The effect of cataract and other media opacities on functional vision is typically assessed clinically using visual acuity. In both clinical and basic research, straylight (the functional result of light scattering in the eye) is commonly measured. The purpose of the present study was to determine the link between these two measures: is visual acuity in cataract and other media opacities related to straylight? METHODS: Interdependence between acuity and straylight is addressed from three different points of view: (1) Methodological: can acuity differences affect the measurement value of straylight, and vice versa? (2) Basic optics: does the optical process of light scattering in the human eye affect both straylight and visual acuity? (3) Statistical: how strongly are acuity and straylight correlated in the practice of important clinical conditions? Experimental and theoretical aspects will be considered, with a focus on normal ageing and cataract formation...
March 8, 2017: Ophthalmic & Physiological Optics: the Journal of the British College of Ophthalmic Opticians (Optometrists)
https://www.readbyqxmd.com/read/28251083/predictive-factors-for-photic-phenomena-after-refractive-rotationally-asymmetric-multifocal-intraocular-lens-implantation
#19
Hungwon Tchah, Kiyeun Nam, Aeri Yoo
AIM: To investigate the independent factors associated with photic phenomena in patients implanted with refractive, rotationally asymmetric, multifocal intraocular lenses (MIOLs). METHODS: Thirty-four eyes of 34 patients who underwent unilateral cataract surgery, followed by implantation of rotationally asymmetric MIOLs were included. Distance and near visual acuity outcomes, intraocular aberrations, preferred reading distances, preoperative and postoperative refractive errors, mesopic and photopic pupil diameters, and the mesopic and photopic kappa angles were assessed...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28251082/visual-performance-with-accommodating-and-multifocal-intraocular-lenses
#20
Jie Lan, Yu-Sen Huang, Yun-Hai Dai, Xiao-Ming Wu, Jia-Jun Sun, Li-Xin Xie
AIM: To compare the visual functional outcomes with accommodating and multifocal intraocular lenses (IOLs). METHODS: Our retrospective comparative study included 51 patients (60 eyes) received implantation of an accommodating IOL (Tetraflex; 16 patients, 20 eyes), a refractive multifocal IOL (ReZoom; 18 patients, 20 eyes), or a diffractive multifocal IOL (ZMA00; 17 patients, 20 eyes). Subjective refraction, visual acuity, contrast sensitivity (CS), intraocular aberration, and subjective photic phenomena were detected at 3mo after surgery...
2017: International Journal of Ophthalmology
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