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https://www.readbyqxmd.com/read/28209965/high-amplitude-electrical-stimulation-can-reduce-elicited-neuronal-activity-in-visual-prosthesis
#1
Alejandro Barriga-Rivera, Tianruo Guo, Chih-Yu Yang, Amr Al Abed, Socrates Dokos, Nigel H Lovell, John W Morley, Gregg J Suaning
Retinal electrostimulation is promising a successful therapy to restore functional vision. However, a narrow stimulating current range exists between retinal neuron excitation and inhibition which may lead to misperformance of visual prostheses. As the conveyance of representation of complex visual scenes may require neighbouring electrodes to be activated simultaneously, electric field summation may contribute to reach this inhibitory threshold. This study used three approaches to assess the implications of relatively high stimulating conditions in visual prostheses: (1) in vivo, using a suprachoroidal prosthesis implanted in a feline model, (2) in vitro through electrostimulation of murine retinal preparations, and (3) in silico by computing the response of a population of retinal ganglion cells...
February 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28209589/second-generation-drosophila-chemical-tags-sensitivity-versatility-and-speed
#2
Ben Sutcliffe, Julian Ng, Thomas O Auer, Mathias Pasche, Richard Benton, Gregory S X E Jefferis, Sebastian Cachero
Labeling and visualizing cells and subcellular structures within thick tissues, whole organs and even intact animals is key to studying biological processes. This is particularly true for studies of neural circuits where neurons form submicron synapses but have arbors that may span millimeters in length. Traditionally, labeling is achieved by immunofluorescence; however diffusion of antibody molecules (>100 kDa) is slow and often results in uneven labeling with very poor penetration into the centre of thick specimens; these limitations can be partially addressed by extending staining protocols to over a week (Drosophila brain) and months (mice)...
February 16, 2017: Genetics
https://www.readbyqxmd.com/read/28209364/variable-threshold-method-for-determining-the-boundaries-of-imaged-subvisible-particles
#3
R E Cavicchi, Cayla Collett, Srivalli Telikepalli, Zhishang Hu, Michael Carrier, Dean C Ripple
An accurate assessment of particle characteristics and concentrations in pharmaceutical products by flow imaging requires accurate particle sizing and morphological analysis. Analysis of images begins with the definition of particle boundaries. Commonly a single threshold defines the level for a pixel in the image to be included in the detection of particles, but depending on the threshold level, this results in either missing translucent particles or oversizing of less transparent particles due to the halos and gradients in intensity near the particle boundaries...
February 13, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28209307/indications-and-complications-of-crown-halo-vest-placement-a-review
#4
REVIEW
Dennis Lee, Adeola L Adeoye, Nader S Dahdaleh
Crown halo vest placement remains an option for the treatment of a variety of upper and subaxial cervical spinal fractures. While the device remains a useful non-operative option for the treatment of these injuries, it has been associated with a variety of complications. This manuscript represents an up to date narrative review of the indications, complications, and complication avoidance for the placement of crown halo vests.
February 10, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28203053/refractive-outcomes-and-safety-of-the-implantable-collamer-lens-in-young-low-to-moderate-myopes
#5
Paul J Dougherty, Taylor Priver
PURPOSE: To evaluate visual and refractive outcomes and safety of implantable collamer lens (ICL) implantation in low-to-moderate myopia. SETTING: Private Practice - Dougherty Laser Vision, Westlake Village, CA, USA. METHODS: A chart review was performed in 56 (104 eyes) consecutive patients who underwent implantation of the Visian ICL V4 model. Inclusion criteria were age between 21 and 40 years, spherical equivalent between -3.00 D and -10...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28202480/multimodal-imaging-findings-in-hyper-early-stage-mewds
#6
Armelle Cahuzac, Benjamin Wolff, Thibaud Mathis, Marie-Hélène Errera, José-Alain Sahel, Martine Mauget-Faÿsse
OBJECTIVE: To describe a new stage of multiple evanescent white dot syndrome (MEWDS), occurring at a very early phase of the disease. METHODS: Retrospective analysis of clinical, angiographic and tomographic findings in four patients with 'hyper-early' stage MEWDS. RESULTS: In four patients seen within 1 week of the onset of symptoms, fundus analysis revealed macular granity and the classic yellow-white dots, some having no corresponding hyperautofluorescent pattern...
February 15, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28199131/how-satisfied-are-patients-with-their-radiologists-assessment-using-a-national-patient-ratings-website
#7
Luke A Ginocchio, Richard Duszak, Andrew B Rosenkrantz
OBJECTIVE: The purpose of this study is to assess features of patient satisfaction scores for U.S. radiologists using a popular physician rating website. MATERIALS AND METHODS: Patient reviews were retrieved from the website RateMDs for all listed radiologists in all 297 U.S. cities with population 100,000 or greater. Reviews included rating scores of 1-5 (5 = highest) in four categories (staff, punctuality, knowledge, and helpfulness). Additional physician information was obtained from Medicare files...
February 15, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28198102/master-maker-understanding-gaming-skill-through-practice-and-habit-from-gameplay-behavior
#8
Jeff Huang, Eddie Yan, Gifford Cheung, Nachiappan Nagappan, Thomas Zimmermann
The study of expertise is difficult to do in a laboratory environment due to the challenge of finding people at different skill levels and the lack of time for participants to acquire mastery. In this paper, we report on two studies that analyze naturalistic gameplay data using cohort analysis to better understand how skill relates to practice and habit. Two cohorts are analyzed, each from two different games (Halo Reach and StarCraft 2). Our work follows skill progression through 7 months of Halo matches for a holistic perspective, but also explores low-level in-game habits when controlling game units in StarCraft 2...
February 15, 2017: Topics in Cognitive Science
https://www.readbyqxmd.com/read/28195381/mild-aqueous-%C3%AE-arylation-of-ketones-towards-new-diversification-tools-for-halogenated-metabolites-and-drug-molecules
#9
Enrico Marelli, Yohann Renault, Sunil V Sharma, Steven P Nolan, Rebecca Jane Miriam Goss
The palladium-catalyzed aqueous α-arylation of ketones was developed and tested for a large variety of reaction partners. These mild conditions enabled the coupling of aryl/ alkyl-ketones with N-protected halotryptophans, heterocyclic haloarenes, and challenging base-sensitive compounds. The synthetic potential of this new methodology for the diversification of complex bioactive molecules was exemplified by derivatising prochlorperazine. The methodology is mild, aqueous and flexible, representing a means of functionalizing a wide range of halo-aromatics and therefore has the potential to be extended to complex molecule diversification...
February 14, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28190625/-the-inverted-halo-sign-in-a-febrile-neutropenic-patient
#10
R Perolat, O Stephanov, A Mounier, A Thiebaut, A Pirvu, R Hamidfar, G Ferretti
No abstract text is available yet for this article.
February 9, 2017: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/28188609/investigation-of-the-clinical-features-of-geographic-tongue-unveiling-its-relationship-with-oral-psoriasis
#11
Bruna Picciani, Vanessa de Carla Santos, Thays Teixeira-Souza, Lívia Maria Izahias, Áquila Curty, João Carlos Avelleira, David Azulay, Jane Pinto, Sueli Carneiro, Eliane Dias
BACKGROUND: Few studies have examined the clinical features of geographic tongue (GT), an inflammatory lesion, making diagnosis and the investigation of oral psoriasis difficult. PURPOSE: To investigate the clinical features of GT to facilitate its identification and understand its relationship with psoriasis. METHODS: A total of 96 participants diagnosed with GT underwent stomatological and dermatological examinations. The parameters assessed were burning sensation; number, classification, and location of lesions; loss of papillae; severity of GT lesions; and association with fissured tongue (FT)...
February 10, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28185083/posterior-only-surgery-with-preoperative-skeletal-traction-for-management-of-severe-scoliosis
#12
Saeedreza Mehrpour, Reza Sorbi, Reza Rezaei, Keyvan Mazda
PURPOSE: The surgical treatment of severe adolescent spinal deformities is challenging and carries substantial risks of mortality and morbidity. To mitigate this risk, surgeons have employed various methods as this study designed to evaluate the safety and effectiveness of preoperative halo-femoral or halo gravity traction (HGT) followed by posterior-only surgery in the management of severe scoliosis. METHOD: A total number of 23 patients with severe scoliosis treated by preoperative skeletal traction (halo gravity or halo femoral) followed by posterior fusion and instrumentation in one stage...
February 10, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28182082/cytomorphometric-analysis-and-morphological-assessment-of-oral-exfoliated-cells-in-type-2-diabetes-mellitus-and-healthy-individuals-a-comparative-study
#13
Khushboo Sahay, Shweta Rehani, Priyanka Kardam, Madhumani Kumra, Rashi Sharma, Nisha Singh
CONTEXT: Oral exfoliative cytology is a simple, nonaggressive technique that is well accepted by patients. Therefore, it is an attractive option, which aids in the diagnosis and observation of epithelial atypias associated with oral mucosal diseases. AIMS: The aim of this study was to evaluate and compare the quantitative and qualitative alterations in exfoliative smears from type 2 diabetics and healthy individuals. PATIENTS AND METHODS: The study includes 30 type 2 diabetics and 30 healthy persons of both sexes...
January 2017: Journal of Cytology
https://www.readbyqxmd.com/read/28180034/surrogate-gas-prediction-model-as-a-proxy-for-%C3%AE-14-c-based-measurements-of-fossil-fuel-co2
#14
Kevin J Coakley, John B Miller, Stephen A Montzka, Colm Sweeney, Ben R Miller
The measured (14)C:(12)C isotopic ratio of atmospheric CO2 (and its associated derived Δ(14)C value) is an ideal tracer for determination of the fossil fuel derived CO2 enhancement contributing to any atmospheric CO2 measurement (Cff ). Given enough such measurements, independent top-down estimation of US fossil fuel-CO2 emissions should be possible. However, the number of Δ(14)C measurements is presently constrained by cost, available sample volume, and availability of mass spectrometer measurement facilities...
June 27, 2016: Journal of Geophysical Research. Atmospheres: JGR
https://www.readbyqxmd.com/read/28177173/perioperative-considerations-in-infantile-neuroaxonal-dystrophy
#15
Jina L Sinskey, Robert S Holzman
Infantile neuroaxonal dystrophy is a rare neurological disorder that is universally fatal with life expectancy under 10 years. A 10-year-old boy with infantile neuroaxonal dystrophy and severe neuromuscular scoliosis underwent posterior spinal fusion following halo traction. He was successfully extubated to bilevel positive airway pressure on postoperative day 3 and discharged home on postoperative day 11. Infantile neuroaxonal dystrophy presents several perioperative challenges including concerns for difficult intubation and respiratory dysfunction...
February 8, 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/28168589/impact-of-pet-acquisition-durations-on-image-quality-and-lesion-detectability-in-whole-body-68-ga-psma-pet-mri
#16
Benjamin Noto, Florian Büther, Katharina Auf der Springe, Nemanja Avramovic, Walter Heindel, Michael Schäfers, Thomas Allkemper, Lars Stegger
BACKGROUND: While (68)Ga-PSMA PET-MRI might be superior to PET-CT with regard to soft tissue assessment in prostate cancer evaluation, it is also known to potentially introduce additional PET image artefacts. Therefore, the impact of PET acquisition duration and attenuation data on artefact occurrence, lesion detectability, and quantification was investigated. To this end, whole-body PET list mode data from 12 patients with prostate cancer were acquired 1 h after injection of 2 MBq/kg [(68)Ga]HBED-CC-PSMA on a hybrid PET-MRI system...
December 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28168257/a-finite-element-model-of-granular-serotonin-exocytosis
#17
Ankurita Datta, Christy L Haynes, Victor H Barocas
Signaling molecules stored in cellular granules serve a broad range of functional purposes. Serotonin, for example, is involved in the regulation of behavior, cognitive function, and hemostasis. Understanding serotonin release from platelet granules can provide valuable fundamental information about the exocytotic process and help elucidate potential abnormalities of diseased platelets. Experimentally, carbon-fiber microelectrochemistry has been utilized to characterize the dynamic behavior of serotonin secretion from individual platelets...
February 7, 2017: Integrative Biology: Quantitative Biosciences From Nano to Macro
https://www.readbyqxmd.com/read/28165609/comparison-of-visual-outcomes-after-bilateral-implantation-of-extended-range-of-vision-and-trifocal-intraocular-lenses
#18
Ramón Ruiz-Mesa, Antonio Abengózar-Vela, Ana Aramburu, María Ruiz-Santos
PURPOSE: To compare visual outcomes after cataract surgery with bilateral implantation of 2 intraocular lenses (IOLs): extended range of vision and trifocal. METHODS: Each group of this prospective study comprised 40 eyes (20 patients). Phacoemulsification followed by bilateral implantation of a FineVision IOL (group 1) or a Symfony IOL (group 2) was performed. The following outcomes were assessed up to 1 year postoperatively: binocular uncorrected distance visual acuity (UDVA), binocular uncorrected intermediate visual acuity (UIVA) at 60 cm, binocular uncorrected near visual acuity (UNVA) at 40 cm, spherical equivalent (SE) refraction, defocus curves, mesopic and photopic contrast sensitivity, halometry, posterior capsule opacification (PCO), and responses to a patient questionnaire...
January 28, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28164699/diastereoselective-organocatalytic-addition-of-%C3%AE-angelica-lactone-to-%C3%AE-halo-%C3%AE-ketoesters
#19
Jessica A Griswold, Matthew A Horwitz, Leslie V Leiva, Jeffrey S Johnson
A quinidine-catalyzed diastereoselective addition of α-angelica lactone to β-halo-α-ketoesters is reported. The α-angelica lactone displays unusual regioselectivity in this reaction, acting as a nucleophile at the α-position to provide fully substituted glycolic esters with three contiguous stereocenters. Subsequent diastereoselective hydrogenation provides an additional stereocenter within the lactone.
February 6, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28162180/-an-analysis-of-clinical-characteristics-of-twelve-cases-of-mesenteric-panniculitis
#20
Q W Jiang, F D Wang, W Z Wang, X Wu, H J Shu, J N Li, A M Yang, J M Qian, D Wu
Objective: Mesenteric panniculitis is an idiopathic, uncommon disease involving the adipose tissue of mesentery. The etiology, diagnosis and treatment are still unnoticed. We thus reported a case series to improve the understanding of this rare disorder. Methods: We retrospectively analyzed the clinical data of 12 patients with mesenteric panniculitis including manifestation, diagnosis, treatment and prognosis. Results: We found a male predominance (M∶F 3∶1) with the median age of 58 years old at diagnosis...
February 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
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