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https://www.readbyqxmd.com/read/28538030/efficacy-of-cyclosporine-after-autologous-noncultured-melanocyte-transplantation-in-localized-stable-vitiligo-a-pilot-open-label-comparative-study
#1
Sharad Mutalik, Swapnil Shah, Varsha Sidwadkar, Meenaz Khoja
BACKGROUND: Understanding the pathogenesis of vitiligo has lead to innovation of new drugs and new uses of the existing drugs to enhance treatment outcome. OBJECTIVE: The aim of this observational pilot study was to assess the role of cyclosporine (CsA) to tackle the commonest aesthetic problem "perilesional halo" after autologous noncultured melanocyte-keratinocyte cell transplant (NCMKT) for localized, stable vitiligo. MATERIALS AND METHODS: Of the total 50 enrolled patients who underwent NCMKT for stable/resistant vitiligo, aged 12 to 68 years (mean 29...
May 22, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28534914/covalent-inhibition-of-protein-tyrosine-phosphatases
#2
REVIEW
Kasi Viswanatharaju Ruddraraju, Zhong-Yin Zhang
Protein tyrosine phosphatases (PTPs) are a large family of 107 signaling enzymes that catalyze the hydrolytic removal of phosphate groups from tyrosine residues in a target protein. The phosphorylation status of tyrosine residues on proteins serve as a ubiquitous mechanism for cellular signal transduction. Aberrant function of PTPs can lead to many human diseases, such as diabetes, obesity, cancer, and autoimmune diseases. As the number of disease relevant PTPs increases, there is urgency in developing highly potent inhibitors that are selective towards specific PTPs...
May 23, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/28530808/%C3%AE-halo-amides-as-competent-latent-enolates-direct-cata-lytic-asymmetric-mannich-type-reaction
#3
Bo Sun, Pandur Venkatesan Balaji, Naoya Kumagai, Masakatsu Shibasaki
α-Halogenated carbonyl compounds are susceptible to dehalogenation and thus largely neglected as enolate precursors in catalytic enantioselective C-C bond forming reactions. By merging the increased stability of the α-C-halogen bond of amides and the direct enolization methodology of the designed amide, we explored a direct catalytic asymmetric Mannich-type reaction of α-halo 7-azaindoline amides with N-carbamoyl imines. All α-halo sub-stituents, α-F, -Cl, -Br, -I amides, were tolerated to provide the Mannich-adducts in a highly stereoselective manner without undesirable dehalogenation...
May 22, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28529697/factors-associated-with-preterm-delivery-and-low-birth-weight-a-study-from-rural-maharashtra-india
#4
Anand Ahankari, Sharda Bapat, Puja Myles, Andrew Fogarty, Laila Tata
Background: Although preterm delivery and low birth weight (LBW) have been studied in India, findings may not be generalisable to rural areas such as the Marathwada region of Maharashtra state. There is limited information available on maternal and child health indicators from this region. We aimed to present some local estimates of preterm delivery and LBW in the Osmanabad district of Marathwada and assess available maternal risk factors. Methods: The study used routinely collected data on all in-hospital births in the maternity department of Halo Medical Foundation's hospital from 1 (st) January 2008 to 31 (st) December 2014...
2017: F1000Research
https://www.readbyqxmd.com/read/28527452/structural-and-dynamic-inhomogeneities-induced-by-curvature-gradients-in-elliptic-colloidal-halos-of-paramagnetic-particles
#5
O A Ramírez-Garza, J M Méndez-Alcaraz, P González-Mozuelos
Paramagnetic colloidal particles distributed along an ellipse are used as a model system to study the effects of curvature gradients on the structure and dynamics of colloids in curved manifolds. Unlike what happens for circular and spherical systems, in the present case, the equilibrium one-particle distribution function displays inhomogeneities due to the changing curvature along the ellipse. The ensuing effects on the two-body correlations are also analyzed, leading to the observation of anisotropic and long-ranged effects...
May 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28526346/release-study-and-inhibitory-activity-of-thyme-essential-oil-loaded-chitosan-nanoparticles-and-nanocapsules-against-foodborne-bacteria
#6
M Sotelo-Boyás, Z Correa-Pacheco, S Bautista-Baños, Y Gómez Y Gómez
The antibacterial property of thyme essential oil due to different volatile compounds, has been well documented in the literature. To overcome the high volatility of essential oil components, encapsulation has emerged as a new alternative. In this work, chitosan and thyme essential oil-loaded chitosan nanoparticles (TEO-CSNPs) and nanocapsules (TEO-CSNCs) were prepared by nanoprecipitation and nanoencapsulation, respectively. The morphology, encapsulation efficiency, release kinetics, and inhibitory activity were evaluated...
May 16, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28524667/correction-to-diastereoselective-organocatalytic-addition-of-%C3%AE-angelica-lactone-to-%C3%AE-halo-%C3%AE-ketoesters
#7
Jessica A Griswold, Matthew A Horwitz, Leslie V Leiva, Jeffrey S Johnson
No abstract text is available yet for this article.
May 19, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28523377/mining-lipolytic-enzymes-in-community-dna-from-high-andean-soils-using-a-targeted-approach
#8
Daniel Borda-Molina, José Salvador Montaña, María Mercedes Zambrano, Sandra Baena
Microbial enrichments cultures are a useful strategy to speed up the search for enzymes that can be employed in industrial processes. Lipases have gained special attention because they show unique properties such as: broad substrate specificity, enantio- and regio-selectivity and stability in organic solvents. A major goal is to identify novel lipolytic enzymes from microorganisms living in cold extreme environments such as high Andean soils, of relevance to our study being their capability be used in industrial processes...
May 18, 2017: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/28522382/brain-abscess-following-halo-fixation-for-the-cervical-spine
#9
Arthur Lopes, Almir Andrade, Igor Silva, Wellingson Paiva, Roger Brock, Manoel Teixeira
BACKGROUND: Halo fixation is one of the possible treatments for cervical spine fractures. However, improper use of these devices may lead to many complications, such as pin loosening, halo dislocation, pin site infection, and intradural penetration. CASE DESCRIPTION: We report a 43-year-old man who first presented with a seizure and an altered level of consciousness five months after halo-vest placement for an odontoid fracture. Brain imaging revealed a brain abscess, under the previous left parietal pin...
May 15, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28508120/effects-of-arm-truncation-on-the-appearance-of-the-halo-artifact-in-68-ga-psma-11-hbed-cc-pet-mri
#10
Ali Afshar-Oromieh, Maya Wolf, Uwe Haberkorn, Marc Kachelrieß, Regula Gnirs, Klaus Kopka, Heinz-Peter Schlemmer, Martin T Freitag
PURPOSE: PSMA ligand imaging with hybrid PET/MRI scanners could be an integral part of the clinical routine in the future. However, the first study about this novel method revealed a severe photopenic artifact ("halo artifact") around the urinary bladder causing significantly reduced tumor visibility. The aim of this evaluation was to analyze the role of arm truncation on the appearance of the halo artifact in (68)Ga-PSMA-11 PET/MRI hypothesizing that this influences the appearance. METHODS: Twenty-seven consecutive patients were subjected to (68)Ga-PSMA-11 PET/CT (1 h p...
May 15, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28504099/zoonotic-intestinal-parasites-and-vector-borne-pathogens-in-italian-shelter-and-kennel-dogs
#11
Donato Traversa, Angela Di Cesare, Giulia Simonato, Rudi Cassini, Carmine Merola, Anastasia Diakou, Lénaïg Halos, Frederic Beugnet, Antonio Frangipane di Regalbono
This study investigated the presence of zoonotic parasites and vector-borne pathogens in dogs housed in kennels and shelters from four sites of Italy. A total of 150 adoptable dogs was examined with different microscopic, serological and molecular methods. Overall 129 dogs (86%) were positive for one or more parasites and/or pathogens transmitted by ectoparasites. Forty-eight (32%) were positive for one infection, while 81 (54%) for more than one pathogen. The most common zoonotic helminths recorded were hookworms, roundworms and Capillaria aerophila, followed by mosquito-borne Dirofilaria spp...
April 2017: Comparative Immunology, Microbiology and Infectious Diseases
https://www.readbyqxmd.com/read/28503793/rectus-abdominis-rhabdomyolysis-report-of-2-cases
#12
Jerome Boyle, Paul Marks, John Read
Exercise-induced rhabdomyolysis is an unusual clinical entity for physicians and one that is frequently misdiagnosed. With the ever-increasing use of sonography by radiologists, sonographers, and sports physicians in the diagnosis of acute muscle injury, recognition of the typical sonographic appearance of rhabdomyolysis is paramount. Current literature using high-resolution ultrasound equipment is limited, with much of the literature offering dated or incongruent descriptions. We describe the sonographic findings of hyperechoic muscle and a hypoechoic halo of edema in 2 proven cases of rectus abdominis rhabdomyolysis after exercise...
May 15, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28503707/the-value-of-ultrasound-in-diagnosing-extracranial-large-vessel-vasculitis-compared-to-fdg-pet-ct-a-retrospective-study
#13
Christian Löffler, Johannes Hoffend, Urs Benck, Bernhard K Krämer, Raoul Bergner
Large-vessel vasculitis (LVV) is a group of diseases mainly comprised of giant-cell arteritis (GCA), Takayasu arteritis, and a series of rare diseases like Behçet's disease, IgG4-related disease, infectious aortitis, and other unfrequent entities. Besides clinical and laboratory features, Doppler sonography (DS) can assist in establishing the diagnosis. Its diagnostic sensitivity has been evaluated in various studies, most of them, however, in temporal arteritis (TA) respectively in LVV with involvement of the temporal artery...
May 15, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28493722/synthesis-of-4-halo-3-2h-furanones-using-intramolecular-cyclization-of-sulfonium-salts
#14
Sho Inagaki, Maiko Nakazato, Nozomi Fukuda, Satoru Tamura, Tomikazu Kawano
A simple and efficient synthesis of 4-halo-3(2H)-furanones by halogenative intramolecular cyclization of sulfonium salts is described, which can expedite the production of a variety of 4-bromo- or 4-iodo-3(2H)-furanones, useful synthetic building blocks, in good to high yield under mild conditions.
May 11, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28492864/induction-of-immune-reaction-in-benign-melanocytic-nevi-without-halo-during-nivolumab-therapy-in-a-patient-with-melanoma
#15
Yasuhiro Nakamura, Takashi Fujino, Hiroshi Kagamu, Taisuke Matsuya, Yukiko Teramoto, Yuri Asami, Akifumi Yamamoto
No abstract text is available yet for this article.
May 10, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28489107/a-novel-metal-free-method-for-the-selenocyanation-of-aromatic-ketones-to-afford-%C3%AE-carbonyl-selenocyanates
#16
Kai Sun, Yunhe Lv, Yao Chen, Tingting Zhou, Yanyan Xing, Xin Wang
A new method has been developed for the selenocyanation of aromatic ketones. This reaction avoids the need to use pre-prepared α-halo ketones, providing rapid access to α-carbonyl selenocyanates. We also investigated the mechanism for this reaction and found that it proceeds via sequential radical iodination and nucleophilic substitution reactions.
May 23, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28481788/ipilimumab-induced-organizing-pneumonia-on-18f-fdg-pet-ct-in-a-patient-with-malignant-melanoma
#17
Roy A Raad, Rajni Kannan, Kathleen Madden, Anna Pavlick
A 60-year-old woman with history of vaginal malignant melanoma and inguinal nodal metastases underwent F-FDG PET/CT for restaging following ipilimumab (Yervoy) immunotherapy, a Food and Drug Administration-approved human monoclonal antibody targeting cytotoxic T-lymphocyte-associated antigen 4. PET/CT demonstrated mildly FDG-avid multifocal enlarging bilateral lung opacities. Within each lung lesion, there was circumferential uptake localizing to a high-attenuation rim with a photopenic ground-glass center on CT, consistent with "reversed halo sign...
May 6, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28480161/multiple-cavities-with-halo-sign-in-a-case-of-invasive-pulmonary-aspergillosis-during-therapy-for-drug-induced-hypersensitivity-syndrome
#18
Tomoo Ikari, Katsura Nagai, Masashi Ohe, Toshiyuki Harada, Yasushi Akiyama
A 67-year-old female with rheumatoid arthritis and asthma-chronic obstructive pulmonary disease overlap syndrome was admitted for drug-induced hypersensitivity syndrome (DIHS) caused by salazosulfapyridine. Human herpes virus 6 (HHV-6) variant B was strongly positive on peripheral blood. Multiple cavities with ground grass opacities rapidly emerged predominantly in the upper and middle lobes. She was diagnosed with invasive pulmonary aspergillosis (IPA), and was treated successfully with antifungal agents. Therapeutic systemic corticosteroids, emphysematous change in the lungs, and the worsening of the patient's general condition due to DIHS were considered major contributing factor leading to IPA...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28474932/mass-discrepancy-acceleration-relation-a-natural-outcome-of-galaxy-formation-in-cold-dark-matter-halos
#19
Aaron D Ludlow, Alejandro Benítez-Llambay, Matthieu Schaller, Tom Theuns, Carlos S Frenk, Richard Bower, Joop Schaye, Robert A Crain, Julio F Navarro, Azadeh Fattahi, Kyle A Oman
We analyze the total and baryonic acceleration profiles of a set of well-resolved galaxies identified in the eagle suite of hydrodynamic simulations. Our runs start from the same initial conditions but adopt different prescriptions for unresolved stellar and active galactic nuclei feedback, resulting in diverse populations of galaxies by the present day. Some of them reproduce observed galaxy scaling relations, while others do not. However, regardless of the feedback implementation, all of our galaxies follow closely a simple relationship between the total and baryonic acceleration profiles, consistent with recent observations of rotationally supported galaxies...
April 21, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28474927/measurement-of-a-cosmographic-distance-ratio-with-galaxy-and-cosmic-microwave-background-lensing
#20
Hironao Miyatake, Mathew S Madhavacheril, Neelima Sehgal, Anže Slosar, David N Spergel, Blake Sherwin, Alexander van Engelen
We measure the gravitational lensing shear signal around dark matter halos hosting constant mass galaxies using light sources at z∼1 (background galaxies) and at the surface of last scattering at z∼1100 (the cosmic microwave background). The galaxy shear measurement uses data from the CFHTLenS survey, and the microwave background shear measurement uses data from the Planck satellite. The ratio of shears from these cross-correlations provides a purely geometric distance measurement across the longest possible cosmological lever arm...
April 21, 2017: Physical Review Letters
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