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https://www.readbyqxmd.com/read/28737177/a-metal-free-cascade-reaction-of-%C3%AE-halo-%C3%AE-%C3%AE-unsaturated-aldehydes-and-1-4-dithiane-2-5-diols-synthesis-of-polycyclic-2-formylthiophenes
#1
Limi Goswami, Kashmiri Neog, Kumud Sharma, Pranjal Gogoi
A metal-free cascade reaction strategy has been developed for the synthesis of novel polycyclic 2-formylthiophenes from β-halo-α,β-unsaturated aldehydes and 1,4-dithiane-2,5-diols. A recyclable polymer supported organic base was used to perform the reaction process. This synthetic protocol was applied to synthesize several novel polycyclic thiophenes including steroidal D-ring annelated thiophene. Our synthetic strategy provides a high yield of thiophenes, avoids a tedious work-up procedure and minimizes the formation of waste...
July 24, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28737163/plane-dependent-ml-scatter-scaling-3d-extension-of-the-2d-simulated-single-scatter-sss-estimate
#2
Ahmadreza Rezaei, Koen Salvo, Thomas Vahle, Vladimir Panin, Michael Casey, Fernando Boada, Michel Defrise, Johan Nuyts
Scatter correction is typically done using a simulation of the single scatter, which is then scaled to account for multiple scatters and other possible model mismatches. This scaling factor is determined by fitting the simulated scatter sinogram to the measured sinogram, using only counts measured along LORs that do not intersect the patient body, i.e. 'scatter-tails'. Extending previous work, we propose to scale the scatter with a plane dependent factor, which is determined as an additional unknown in the maximum likelihood (ML) reconstructions, using counts in the entire sinogram rather than only the 'scatter-tails'...
July 24, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28736566/genome-wide-linkage-and-association-mapping-of-halo-blight-resistance-in-common-bean-to-race-6-of-the-globally-important-bacterial-pathogen
#3
Andrew J Tock, Deidré Fourie, Peter G Walley, Eric B Holub, Alvaro Soler, Karen A Cichy, Marcial A Pastor-Corrales, Qijian Song, Timothy G Porch, John P Hart, Renato C C Vasconcellos, Joana G Vicente, Guy C Barker, Phillip N Miklas
Pseudomonas syringae pv. phaseolicola (Psph) Race 6 is a globally prevalent and broadly virulent bacterial pathogen with devastating impact causing halo blight of common bean (Phaseolus vulgaris L.). Common bean lines PI 150414 and CAL 143 are known sources of resistance against this pathogen. We constructed high-resolution linkage maps for three recombinant inbred populations to map resistance to Psph Race 6 derived from the two common bean lines. This was complemented with a genome-wide association study (GWAS) of Race 6 resistance in an Andean Diversity Panel of common bean...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28734061/evaluation-of-a-technique-for-color-correction-in-restoring-anterior-teeth
#4
Gabrielle Branco Rauber, Jussara Karina Bernardon, Luiz Clovis Cardoso Vieira, Luiz Narciso Baratieri
OBJECTIVE: This study aimed to evaluate the ability of the proposed technique in producing restorations that exhibit mimesis with tooth structure and to define a restorative clinical protocol. MATERIALS AND METHODS: For this study a typodont was used. The right upper central incisor with Class IV lesion was restored with the layering technique (reference tooth, RT). For the left upper central incisor with Class IV lesion, six teeth were restored monochromatically (test teeth, TT), using DA3...
July 22, 2017: Journal of Esthetic and Restorative Dentistry
https://www.readbyqxmd.com/read/28730525/identification-of-a-seed-coat-specific-promoter-fragment-from-the-arabidopsis-mucilage-modified4-gene
#5
Gillian H Dean, Zhaoqing Jin, Lin Shi, Elahe Esfandiari, Robert McGee, Kylie Nabata, Tiffany Lee, Ljerka Kunst, Tamara L Western, George W Haughn
The Arabidopsis seed coat-specific promoter fragment described is an important tool for basic and applied research in Brassicaceae species. During differentiation, the epidermal cells of the Arabidopsis seed coat produce and secrete large quantities of mucilage. On hydration of mature seeds, this mucilage becomes easily accessible as it is extruded to form a tightly attached halo at the seed surface. Mucilage is composed mainly of pectin, and also contains the key cell wall components cellulose, hemicellulose, and proteins, making it a valuable model for studying numerous aspects of cell wall biology...
July 20, 2017: Plant Molecular Biology
https://www.readbyqxmd.com/read/28710755/rapid-detection-of-bacterial-susceptibility-or-resistance-to-quinolones
#6
Fátima Otero, Rebeca Santiso, María Tamayo, Germán Bou, Jaime Gosálvez, José Luis Fernández
The emergence of multidrug resistant microorganisms together with the decline in discovery and development of new antibiotics is of great concern in health-care policy. In this alarming context, an early and well-tailored antibiotic therapy is a relevant strategy not only to improve clinical outcome but also to avoid appearance and spreading of perilous resistant strains. One of the most common antibiotic classes is fluoroquinolones. They trap the DNA girase and/or topoisomerase IV on the DNA, resulting in DNA fragmentation...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28710754/the-fast-halo-assay-for-the-detection-of-dna-damage
#7
Piero Sestili, Cinzia Calcabrini, Anna Rita Diaz, Carmela Fimognari, Vilberto Stocchi
The need for express screening of the DNA damaging potential of chemicals has progressively increased over the past 20 years due to the wide number of new synthetic molecules to be evaluated, as well as the adoption of more stringent chemical regulations such as the EU REACH and risk reduction politics. In this regard, DNA diffusion assays such as the microelectrophoretic comet assay paved the way for rapid genotoxicity testing. A more significant simplification and speeding up of the experimental processes was achieved with the fast halo assay (FHA) described in the present chapter...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28706397/assessment-of-sperm-deoxyribose-nucleic-acid-fragmentation-using-sperm-chromatin-dispersion-assay
#8
Harsha Pratap, Suma Yekappa Hottigoudar, Kubera Siddappa Nichanahalli, Parkash Chand
The integrity of sperm deoxyribose nucleic acid (DNA) is one of the determinants that ensure normal fertilization, implantation, pregnancy, and the generation of a healthy progeny. Assessment of sperm DNA fragmentation has gained importance as a tool to provide significant information regarding sperm quality, and it can independently predict sperm fertilizing potential. The sperm chromatin dispersion (SCD) assay is one of the available techniques to detect sperm DNA damage with results comparable to the gold standard - Sperm Chromatin Structure Assay...
April 2017: Journal of Pharmacology & Pharmacotherapeutics
https://www.readbyqxmd.com/read/28705516/dermoscopy-of-pigmented-actinic-keratosis-of-the-face-a-study-of-232-cases
#9
A Kelati, H Baybay, E Moscarella, G Argenziano, S Gallouj, F Z Mernissi
The diagnosis of pigmented actinic keratosis (PAK) is often challenging because of overlapping features with lentigo maligna. OBJECTIVE: To investigate dermoscopic patterns of PAK according to their different evolutionary stages, and to correlate the pattern with clinical characteristics of the patients. METHODS: Descriptive and analytical study of 232 PAK. Dermoscopic patterns were divided into two categories: the follicule surroundings' abnormalities (FSA) and follicular keratosis' abnormalities (FKA)...
July 11, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28702002/production-of-lipopeptide-biosurfactant-by-a-marine-nesterenkonia-sp-and-its-application-in-food-industry
#10
George S Kiran, Sethu Priyadharsini, Arya Sajayan, Gopal B Priyadharsini, Navya Poulose, Joseph Selvin
Biosurfactants are smart biomolecules which have wide spread application in medicines, processed foods, cosmetics as well as in bioremediation. In food industry, biosurfactants are used as emulsion stabilizing agents, antiadhesives, and antimicrobial/antibiofilm agents. Nowadays biosurfactant demands in industries has increased tremendously and therefore new bacterial strains are being explored for large scale production of biosurfactants. In this study, an actinobacterial strain MSA31 was isolated from a marine sponge Fasciospongia cavernosa which showed high activity in biosurfactant screening assays such as drop collapsing, oil displacement, lipase and emulsification...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28700493/halo-pelvic-traction-for-severe-kyphotic-deformity-secondary-to-spinal-tuberculosis
#11
Aikeremujiang Muheremu, Yuan Ma, Yong Ma, Junyi Ma, Junjie Cheng, Jiang Xie
To evaluate the efficacy and safety of Halo-pelvic ring traction in the treatment of severe kyphotic deformity secondary to spinal tuberculosis.Eighty patients with severe kyphotic deformity due to spinal tuberculosis were included in the study. Forty of those patients (experimental group) received Halo- pelvic ring traction before surgery and the rest (control group) received surgical treatment directly. Two groups were compared by means of the duration of surgery, intraoperative blood loss, correction of Cobb angle, change in patient height, and American Spinal Injury Association (ASIA) impairment scale...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28693244/improvement-of-diagnostic-efficiency-in-distinguishing-the-benign-and-malignant-thyroid-nodules-via-conventional-ultrasound-combined-with-ultrasound-contrast-and-elastography
#12
Mei-Juan Liu, Yan-Ming Men, Yong-Lin Zhang, Yu-Xi Zhang, Hao Liu
We aimed to evaluate the diagnostic values of conventional ultrasound (US), ultrasound contrast (UC) and ultrasound elastography (UE) in distinguishing the benign and malignant thyroid nodules. A total of 100 patients with thyroid nodules receiving operative treatment were selected; they underwent the conventional US, UE and UC examinations before operation, respectively. The nodules received pathological examination after operation to distinguish benign from malignant lesions. The sensitivity, specificity and diagnostic accordance rate of each diagnostic method was evaluated by receiver operating characteristic (ROC) curve, and the area under the curve (AUC) of ROC was calculated...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28690040/bioactivity-of-ceftazidime-and-fluconazole-included-in-polymethyl-methacrylate-bone-cement-for-use-in-arthroplasty
#13
J Martínez-Moreno, V Merino, A Nácher, J L Rodrigo, Blanca B Bonet Yuste, M Merino-Sanjuán
BACKGROUND: The microorganisms that most frequently cause prosthetic joint infection are methicillin-resistant Staphylococcus aureus and gram-negative aerobic bacillus. Studies have documented the efficacy of mixing antibiotics with polymethyl methacrylate, but that of antifungal drugs has not received much attention. The objective of this in vitro study was to characterize the elution profile and bioactivity of ceftazidime and fluconazole when incorporated into bone cement in proportions intended for prophylaxis and treatment of bone infections...
May 4, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28684981/synthesis-and-enzymatic-ketonization-of-the-5-halo-2-hydroxymuconates-and-5-halo-2-hydroxy-2-4-pentadienoates
#14
Tyler M M Stack, William H Johnson Jr, Christian P Whitman
5-Halo-2-hydroxymuconates and 5-halo-2-hydroxy-2,4-pentadienoates are stable dienols that are proposed intermediates in bacterial meta-fission pathways for the degradation of halogenated aromatic compounds. The presence of the halogen raises questions about how the bulk and/or electronegativity of these substrates would affect enzyme catalysis or whether some pathway enzymes have evolved to accommodate it. To address these questions, 5-halo-2-hydroxymuconates and 5-halo-2-hydroxy-2,4-pentadienoates (5-halo = Cl, Br, F) were synthesized and a preliminary analysis of their enzymatic properties carried out...
2017: Beilstein Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28682833/cross-platform-comparison-of-computer-assisted-image-analysis-quantification-of-in-situ-mrna-hybridization-in-investigative-pathology
#15
Timothy R Holzer, Jeffrey C Hanson, Erin M Wray, Jason A Bailey, Kim R Kennedy, Patrick R Finnegan, Aejaz Nasir, Kelly M Credille
Although availability of automated platforms has proliferated, there is no standard practice for computer-assisted generation of scores for mRNA in situ hybridization (ISH) visualized by brightfield microscopic imaging on tissue sections. To address this systematically, an ISH for peptidylprolyl isomerase B (PPIB) (cyclophilin B) mRNA was optimized and applied to a tissue microarray of archival non-small cell lung carcinoma cases, and then automated image analysis for PPIB was refined across 4 commercially available software platforms...
July 4, 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/28678298/%C3%AE-halo-carbonyls-enable-meta-selective-primary-secondary-and-tertiary-c-h-alkylations-by-ruthenium-catalysis
#16
Andrew J Paterson, Callum J Heron, Claire L McMullin, Mary F Mahon, Neil J Press, Christopher G Frost
A catalytic meta selective C-H alkylation of arenes is described using a wide range of α-halo carbonyls as coupling partners. Previously unreported primary alkylations with high meta selectivity have been enabled by this methodology whereas using straight chain alkyl halides affords ortho substituted products. Mechanistic analysis reveals an activation pathway whereby cyclometalation with a ruthenium(ii) complex activates the substrate molecule and is responsible for the meta selectivity observed. A distinct second activation of the coupling partner allows site selective reaction between both components...
July 19, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28678026/transoral-closed-reduction-of-fixed-atlanto-axial-rotatory-subluxation-aars-in-childhood-and-adolescence
#17
Dezsoe Jeszenszky, Tamas Fekete, Frank Kleinstück, Daniel Haschtmann, Markus Loibl
Atlanto-axial rotatory-subluxation (AARS) is the most common pediatric cervical spine injury. Patients usually present with contralateral rotation and inclination of the upper cervical spine after minor trauma, or associated with an infection of the upper respiratory tract. According to the authors, initial management of patients with acute and chronic AARS type I-II should comprise closed reduction and immobilization with a cervical collar or a Halo-Body-Jacket. Surgical options of open reduction or C1/2 fusion should be restricted to irreducible or recurrent subluxations...
July 3, 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28672207/removal-of-disinfection-byproduct-dbp-precursors-in-water-by-two-stage-biofiltration-treatment
#18
Jie Fu, Wan-Ning Lee, Clark Coleman, Kirk Nowack, Jason Carter, Ching-Hua Huang
The removal of precursors of 36 disinfection byproducts (DBPs) in effluents from flocculation/sedimentation process was evaluated across a pilot-scale two-stage biofiltration process, i.e., a sand/anthracite (SA) biofilter (empty bed contact time (EBCT) of 7.5 min) coupled with a biologically-active granular activated carbon (GAC) contactor (EBCT of 15 min). The biofiltration process exhibited a good capacity for removal of the total DBP formation potential (DBPFP) (by 25.90 ± 2.63%), and GAC contactors contributed most to the DBPFP removal (accounting for 60...
June 27, 2017: Water Research
https://www.readbyqxmd.com/read/28668915/mechanical-ventilation-and-cytopathological-changes-in-the-oral-mucosa
#19
Ana Carolina Machado Landgraf, Angélica Reinheimer, Júlio Cezar Merlin, Soraya de Azambuja Berti Couto, Paulo Henrique Couto Souza
BACKGROUND: The oral mucosa is an important defense barrier to penetration of microorganisms. Thus, changes in the oral epithelium might indicate risk for infection in intensive care patients receiving mechanical ventilation. OBJECTIVE: To evaluate the oral mucosa of intensive care patients who did or did not receive mechanical ventilation by using liquid-base exfoliative cytology. METHODS: The sample consisted of 3 groups: 27 patients admitted to intensive care during a 7- to 14-day period who received mechanical ventilation, 29 patients admitted during the same period who did not receive mechanical ventilation, and 27 healthy patients who had no lesions in the mouth...
July 2017: American Journal of Critical Care: An Official Publication, American Association of Critical-Care Nurses
https://www.readbyqxmd.com/read/28667276/diagnostic-performance-of-contrast-enhanced-pulmonary-computed-tomography-angiography-for-the-detection-of-angioinvasive-pulmonary-aspergillosis-in-immunocompromised-patients
#20
C Henzler, T Henzler, D Buchheidt, John W Nance, C A Weis, R Vogelmann, U Benck, T Viergutz, T Becher, T Boch, S A Klein, D Heidenreich, L Pilz, M Meyer, P M Deckert, W-K Hofmann, S O Schoenberg, M Reinwald
Invasive pulmonary aspergillosis (IPA) is one of the major complications in immunocompromised patients. The mainstay of diagnostic imaging is non-enhanced chest-computed-tomography (CT), for which various non-specific signs for IPA have been described. However, contrast-enhanced CT pulmonary angiography (CTPA) has shown promising results, as the vessel occlusion sign (VOS) seems to be more sensitive and specific for IPA in hematologic patients. The aim of this study was to evaluate the diagnostic accuracy of CTPA in a larger cohort including non-hematologic immunocompromised patients...
June 30, 2017: Scientific Reports
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