Read by QxMD icon Read


Neydher Berroterán-Infante, Theresa Balber, Petra Fürlinger, Michael Bergmann, Rupert Lanzenberger, Marcus Hacker, Markus Mitterhauser, Wolfgang Wadsak
The overexpression of the translocator protein (TSPO) has been amply reported for a variety of conditions, including neurodegenerative disorders, heart failure, and cancer. Thus, TSPO has been proposed as an excellent imaging biomarker, allowing, in this manner, to obtain an accurate diagnosis and to follow disease progression and therapy response. Accordingly, several radioligands have been developed to accomplish this purpose. In this work, we selected [18 F]FEPPA, as one of the clinical established tracers, and assessed its in vitro performance in colorectal cancer...
March 8, 2018: ACS Medicinal Chemistry Letters
Marcus Unterrainer, C Mahler, L Vomacka, S Lindner, J Havla, M Brendel, G Böning, B Ertl-Wagner, T Kümpfel, V M Milenkovic, R Rupprecht, M Kerschensteiner, P Bartenstein, Nathalie L Albert
PURPOSE: Expression of the translocator protein (TSPO) is upregulated in activated macrophages/microglia and is considered to be a marker of neuroinflammation. We investigated the novel TSPO ligand [18 F]GE-180 in patients with relapsing-remitting multiple sclerosis (RRMS) to determine the feasibility of [18 F]GE-180 PET imaging in RRMS patients and to assess its ability to detect active inflammatory lesions in comparison with the current gold standard, contrast-enhanced magnetic resonance imaging (MRI)...
March 9, 2018: European Journal of Nuclear Medicine and Molecular Imaging
Frederick Bonsack, Catherine A Foss, Ali S Arbab, Cargill H Alleyne, Martin G Pomper, Sangeetha Sukumari-Ramesh
Intracerebral hemorrhage (ICH) is a fatal stroke subtype with significant public health impact. Although neuroinflammation is a leading cause of neurological deficits after ICH, no imaging tool is currently available to monitor brain inflammation in ICH patients. Given the role of TSPO in neuroinflammation, herein we investigate whether a second-generation TSPO ligand, [125 I]IodoDPA-713 can be used to monitor the changes in TSPO expression in a preclinical model of intracerebral hemorrhage. Male CD1 mice were subjected to ICH/Sham...
2018: Frontiers in Neuroscience
Bieneke Janssen, Danielle J Vugts, Albert D Windhorst, Robert H Mach
Neuroinflammation, which involves microglial activation, is thought to play a key role in the development and progression of neurodegenerative diseases and other brain pathologies. Positron emission tomography is an ideal imaging technique for studying biochemical processes in vivo, and particularly for studying the living brain. Neuroinflammation has been traditionally studied using radiotracers targeting the translocator protein 18 kDa, but this comes with certain limitations. The current review describes alternative biological targets that have gained interest for the imaging of microglial activation over recent years, such as the cannabinoid receptor type 2, cyclooxygenase-2, the P2X₇ receptor and reactive oxygen species, and some promising radiotracers for these targets...
March 8, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Cornelius K Donat, Nazanin Mirzaei, Sac-Pharm Tang, Paul Edison, Magdalena Sastre
Deficits in neuronal function and synaptic plasticity in Alzheimer's disease (AD) are believed to be linked to microglial activation. A hallmark of reactive microglia is the upregulation of mitochondrial translocator protein (TSPO) expression. Positron emission tomography (PET) is a nuclear imaging technique that measures the distribution of trace doses of radiolabeled compounds in the body over time. PET imaging using the 2nd generation TSPO tracer [11 C]PBR28 provides an opportunity for accurate visualization and quantification of changes in microglial density in transgenic mouse models of Alzheimer's disease (AD)...
2018: Methods in Molecular Biology
Barbara Costa, Eleonora Da Pozzo, Claudia Martini
Two interesting papers by Barren et al. and Owen et al. have been very recently published in Biochemical Journal , reporting the role of translocator protein (TSPO) in steroidogenesis. The involvement of TSPO in the steroid biosynthesis has been suggested by 30 years of researches, using biochemical, pharmacological and genetic experimental approaches. In the last 3 years, however, the TSPO involvement in steroidogenesis has been intensively and profoundly discussed. Using in vivo genetic manipulations aimed at deleting TSPO, some researchers have excluded its role in steroid production...
March 6, 2018: Biochemical Journal
Xu-Bo Li, An Liu, Le Yang, Kun Zhang, Yu-Mei Wu, Ming-Gao Zhao, Shui-Bing Liu
The 18 kDa translocator protein (TSPO) is primarily localized in the outer mitochondrial membrane of steroid-synthesizing cells in the central and peripheral nervous systems. One of the protein's main functions is transporting substrate cholesterol into the mitochondria in a prerequisite process for steroid synthesis. Clinical trials have indicated that TSPO ligands might be valuable in treating some neuropathies and psychopathies. However, limited information is known about the role of TSPO in postpartum depression (PPD)...
March 5, 2018: Molecular Brain
Dewei Tang, Masayuki Fujinaga, Akiko Hatori, Yiding Zhang, Tomoteru Yamasaki, Lin Xie, Wakana Mori, Katsushi Kumata, Jianjun Liu, H Charles Manning, Gang Huang, Ming-Rong Zhang
Translocator Protein (18 kDa, TSPO) is regarded as a useful biomarker for neuroinflammation imaging. TSPO PET imaging could be used to understand the role of neuroinflammation in brain diseases and as a tool for evaluating novel therapeutic effects. As a promising TSPO probe, [18 F]DPA-714 is highly specific and offers reliable quantification of TSPO in vivo. In this study, we further radiosynthesized and evaluated another novel TSPO probe, 2-(7-butyl-2-(4-(2-[18 F]fluoroethoxy)phenyl)-5-methylpyrazolo[1,5-a]pyrimidin-3-yl)-N,N-diethylacetamide ([18 F]VUIIS1018A), which features a 700-fold higher binding affinity for TSPO than that of [18 F]DPA-714...
February 24, 2018: European Journal of Medicinal Chemistry
Elaine Setiawan, Sophia Attwells, Alan A Wilson, Romina Mizrahi, Pablo M Rusjan, Laura Miler, Cynthia Xu, Sarita Sharma, Stephen Kish, Sylvain Houle, Jeffrey H Meyer
BACKGROUND: People with major depressive disorder frequently exhibit increasing persistence of major depressive episodes. However, evidence for neuroprogression (ie, increasing brain pathology with longer duration of illness) is scarce. Microglial activation, which is an important component of neuroinflammation, is implicated in neuroprogression. We examined the relationship of translocator protein (TSPO) total distribution volume (VT ), a marker of microglial activation, with duration of untreated major depressive disorder, and with total illness duration and antidepressant exposure...
February 26, 2018: Lancet Psychiatry
Fiona Henderson, Philippa J Hart, Jesus M Pradillo, Michael Kassiou, Lidan Christie, Kaye J Williams, Herve Boutin, Adam McMahon
RATIONALE: Stroke is a leading cause of disability worldwide. Understanding the recovery process post-stroke is essential; however, longer-term recovery studies are lacking. In-vivo Positron emission tomography (PET) can image biological recovery processes, but is limited by spatial resolution and its targeted nature. Untargeted mass spectrometry imaging offers high spatial resolution, providing an ideal ex-vivo tool for brain recovery imaging. METHODS: Magnetic resonance imaging (MRI) was used to image a rat brain 48 hours after ischaemic stroke to locate the infarcted regions of the brain...
February 27, 2018: Rapid Communications in Mass Spectrometry: RCM
Dibya Ghimire, Madhu Rai, Ritu Gaur
Human immunodeficiency virus-1 (HIV-1) is known to interact with multiple host cellular proteins during its replication in the target cell. While many of these host cellular proteins facilitate viral replication, a number of them are reported to inhibit HIV-1 replication at various stages of its life cycle. These host cellular proteins, which are known as restriction factors, constitute an integral part of the host's first line of defence against the viral pathogen. Since the discovery of apolipoprotein B mRNA-editing enzyme 3G (APOBEC3G) as an HIV-1 restriction factor, several human proteins have been identified that exhibit anti-HIV-1 restriction...
February 19, 2018: Journal of General Virology
Daniel Albrecht, Shihab Ahmed, Norman Kettner, Ronald Borra, Julien Cohen-Adad, Hao Deng, Timothy Houle, Arissa Opalacz, Sarah Roth, Marcos Vidal Melo, Lucy Chen, Jianren Mao, Jacob Hooker, Marco L Loggia, Yi Zhang
Numerous preclinical studies support the role of spinal neuroimmune activation in the pathogenesis of chronic pain, and targeting glia (e.g., microglia/astrocyte)- or macrophage-mediated neuroinflammatory responses effectively prevents or reverses the establishment of persistent nocifensive behaviors in laboratory animals. However, thus far the translation of those findings into novel treatments for clinical use has been hindered by the scarcity of data supporting the role of neuroinflammation in human pain...
February 5, 2018: Pain
Alan R Prossin, Matthew Chandler, Kelly A Ryan, Erika F Saunders, Masoud Kamali, Vassilios Papadopoulos, Sebastian Zöllner, Robert Dantzer, Melvin G McInnis
INTRODUCTION: Psychosocial stress contributes to onset/exacerbation of mood episodes and alcohol use, suggesting dysregulated diurnal cortisol rhythms underlie episodic exacerbations in Bipolar Disorder (BD). However, mechanisms underlying dysregulated HPA rhythms in BD and alcohol use disorders (AUD) are understudied. Knowledge of associated variance factors have great clinical translational potential by facilitating development of strategies to reduce stress-related relapse in BD and AUD...
January 30, 2018: Psychoneuroendocrinology
William C Kreisl, Ioline D Henter, Robert B Innis
Neuroinflammation has long been considered a potential contributor to neurodegenerative disorders that result in dementia. Accumulation of abnormal protein aggregates in Alzheimer's disease, frontotemporal dementia, and dementia with Lewy bodies is associated with the activation of microglia and astrocytes into proinflammatory states, and chronic low-level activation of glial cells likely contributes to the pathological changes observed in these and other neurodegenerative diseases. The 18kDa translocator protein (TSPO) is a key biomarker for measuring inflammation in the brain via positron emission tomography (PET)...
2018: Advances in Pharmacology
Moshe Gavish, Leo Veenman
In 1999, the enigma of the 18kDa mitochondrial translocator protein (TSPO), also known as the peripheral-type benzodiazepine receptor, was the seeming disparity of the many functions attributed to TSPO, ranging from the potential of TSPO acting as a housekeeping gene at molecular biological levels to adaptations to stress, and even involvement in higher emotional and cognitive functioning, such as anxiety and depression. In the years since then, knowledge regarding the many functions modulated by TSPO has expanded, and understanding has deepened...
2018: Advances in Pharmacology
Carlos Eduardo Sampaio Guedes, Beatriz Rocha Simões Dias, Antonio Luis de Oliveira Almeida Petersen, Kercia Pinheiro Cruz, Niara de Jesus Almeida, Daniela Rodrigues Andrade, Juliana Perrone Bezerra de Menezes, Valéria de Matos Borges, Patricia Sampaio Tavares Veras
BACKGROUND: Leishmaniasis, one of the most neglected diseases, is a serious public health problem in many countries, including Brazil. Currently available treatments require long-term use and have serious side effects, necessitating the development of new therapeutic interventions. Because translocator protein (TSPO) levels are reduced in Leishmania amazonensis-infected cells and because this protein participates in apoptosis and immunomodulation, TSPO represents a potential target for Leishmania chemotherapy...
February 5, 2018: Memórias do Instituto Oswaldo Cruz
Tomoyasu Bunai, Tatsuhiro Terada, Satoshi Kono, Masamichi Yokokura, Etsuji Yoshikawa, Masami Futatsubashi, Hiroaki Miyajima, Yasuomi Ouchi
INTRODUCTION: Chronic activation of microglia accelerates the neurodegenerative process in multiple sclerosis (MS). Although disease modifying therapy (DMT) is reportedly effective for neuroinflammatory responses in MS, the progression of neuroinflammation after DMT remains unclear. METHODS: We evaluated microglial activation in six clinically stable relapsing-remitting MS patients after DMT by quantifying changes in translocator protein (TSPO) density using PET with [11C]DPA713, a selective TSPO tracer for microglial activation...
February 15, 2018: Journal of the Neurological Sciences
Sara Belloli, Lucia Zanotti, Valentina Murtaj, Cristina Mazzon, Giuseppe Di Grigoli, Cristina Monterisi, Valeria Masiello, Leonardo Iaccarino, Andrea Cappelli, Pietro Luigi Poliani, Letterio Salvatore Politi, Rosa Maria Moresco
BACKGROUND: Positron emission tomography (PET) using translocator protein (TSPO) ligands has been used to detect neuroinflammatory processes in neurological disorders, including multiple sclerosis (MS). The aim of this study was to evaluate neuroinflammation in a mouse MS model (EAE) using TSPO-PET with18 F-VC701, in combination with magnetic resonance imaging (MRI). METHODS: MOG35-55 /CFA and pertussis toxin protocol was used to induce EAE in C57BL/6 mice. Disease progression was monitored daily, whereas MRI evaluation was performed at 1, 2, and 4 weeks post-induction...
February 5, 2018: Journal of Neuroinflammation
José M Benlloch, Antonio J González, Roberto Pani, Enrico Preziosi, Carl Jackson, John Murphy, Julio Barberá, Carlos Correcher, Sebastian Aussenhofer, Daniel Gareis, Dimitris Visvikis, Julien Bert, Bengt Langstrom, Lars Farde, Miklos Toth, Jenny Haggkvist, Fabio V Caixeta, Klas Kullander, Ian Somlai-Schweiger, Markus Schwaiger
We present the first results of the MINDVIEW project. An innovative imaging system for the human brain examination, allowing simultaneous acquisition of PET/MRI images, has been designed and constructed. It consists of a high sensitivity and high resolution PET scanner integrated in a novel, head-dedicated, radio frequency coil for a 3T MRI scanner. Preliminary measurements from the PET scanner show sensitivity 3 times higher than state-of-the-art PET systems that will allow safe repeated studies on the same patient...
February 1, 2018: European Psychiatry: the Journal of the Association of European Psychiatrists
Daisuke Fukudome, Lindsay N Hayes, Travis E Faust, Catherine A Foss, Mari A Kondo, Brian J Lee, Atsushi Saito, Shin-Ichi Kano, Jennifer M Coughlin, Atsushi Kamiya, Martin G Pomper, Akira Sawa, Minae Niwa
Changes in inflammatory cascades have been implicated in the underlying pathophysiology of psychosis. Translocator protein 18 kDa (TSPO) has been used to assess neuroinflammatory processes in psychotic disorders. Nonetheless, it is unclear whether TSPO, a mitochondrial protein, can be interpreted as a general marker for inflammation in diseases involving psychosis. To address this question, we investigated TSPO signaling in representative mouse models for psychosis with inflammatory disturbances. The maternal immune activation and cuprizone short-term exposure models show different TSPO signaling...
February 2, 2018: Schizophrenia Research
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"