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https://www.readbyqxmd.com/read/29783120/canine-mesenchymal-stem-cells-treated-with-tnf-%C3%AE-and-ifn-%C3%AE-enhance-anti-inflammatory-effects-through-the-cox-2-pge-2-pathway
#1
Hye-Mi Yang, Woo-Jin Song, Qiang Li, Su-Yeon Kim, Hyeon-Jin Kim, Min-Ok Ryu, Jin-Ok Ahn, Hwa-Young Youn
Mesenchymal stem cells (MSCs) have been used in studies on treatment of various diseases, and their application to immune-mediated diseases has garnered interest. Various methods for enhancing the immunomodulation effect of human MSCs have been used; however, similar approaches for canine MSCs are relatively unexplored. Accordingly, we evaluated immunomodulatory effects and mechanisms in canine MSCs treated with TNF-α and IFN-γ. Lipopolysaccharide (LPS)-stimulated RAW 264.7 cells were incubated with the conditioned media (CM) from canine MSCs for 48 h...
May 14, 2018: Research in Veterinary Science
https://www.readbyqxmd.com/read/29779175/anthocyanins-improve-hippocampus-dependent-memory-function-and-prevent-neurodegeneration-via-jnk-akt-gsk3%C3%AE-signaling-in-lps-treated-adult-mice
#2
Muhammad Sohail Khan, Tahir Ali, Min Woo Kim, Myeung Hoon Jo, Jong Il Chung, Myeong Ok Kim
Microglia plays a critical role in the brain and protects neuronal cells from toxins. However, over-activation of microglia leads to deleterious effects. Lipopolysaccharide (LPS) has been reported to affect neuronal cells via activation of microglia as well as directly to initiate neuroinflammation. In the present study, we evaluated the anti-inflammatory and anti-oxidative effect of anthocyanins against LPS-induced neurotoxicity in an animal model and in cell cultures. Intraperitoneal injections of LPS (250 μg/kg/day for 1 week) induce ROS production and promote neuroinflammation and neurodegeneration which ultimately leads to memory impairment...
May 19, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29779084/disease-activity-patterns-recorded-using-a-mobile-monitoring-system-are-associated-with-clinical-outcomes-of-patients-with-crohn-s-disease
#3
Eun Soo Kim, Sung Kook Kim, Byung Ik Jang, Kyeong Ok Kim, Eun Young Kim, Yoo Jin Lee, Hyun Seok Lee, Sang Gyu Kwak
BACKGROUND: Usefulness of a mobile monitoring system for Crohn's disease (CD) has not been evaluated. We aimed to determine whether disease activity patterns depicted using a web-based symptom diary for CD could indicate disease clinical outcomes. METHODS: Patients with CD from tertiary hospitals were prospectively invited to record their symptoms using a smartphone at least once a week. Disease activity patterns for at least 2 months were statistically classified into good and poor groups based on two factors in two consecutive time frames; the degree of score variation (maximum-minimum) in each frame and the trend (upward, stationary, or downward) of patterns indicated by the difference in the mean activity scores between two time frames...
May 19, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29777693/cleavage-of-molybdopterin-synthase-moad-moae-linear-fusion-by-jamm-mpn-domain-containing-metalloprotease-dr0402-from-deinococcus-radiodurans
#4
Yoon-Mo Yang, Young-Bin Won, Chang-Jun Ji, Jung-Hoon Kim, Su-Hyun Ryu, Youn-Ha Ok, Jin-Won Lee
Molybdenum cofactor (Moco), molybdopterin (MPT) complexed with molybdenum, is an essential cofactor required for the catalytic center of diverse enzymes in all domains of life. Since Moco cannot be taken up as a nutrient unlike many other cofactors, Moco requires de novo biosynthesis. During the synthesis of MPT, the sulfur atom on the C-terminus of MoaD is transferred to cyclic pyranopterin monophosphate (cPMP) which is bound in the substrate pocket of MoaE. MoaD is a ubiquitin-like (Ubl) protein and has a C-terminal di-Gly motif which is a common feature of Ubl proteins...
May 16, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29776835/the-combination-of-mannitol-and-temozolomide-increases-the-effectiveness-of-stem-cell-treatment-in-a-chronic-stroke-model
#5
Chunggab Choi, Hye Min Kim, Jeeheun Shon, Jiae Park, Hyeong-Taek Kim, Suk Ho Kang, Seung-Hun Oh, Nam Keun Kim, Ok Joon Kim
BACKGROUND: The blood-brain barrier (BBB) presents a significant challenge to the therapeutic efficacy of stem cells in chronic stroke. Various methods have been developed to increase BBB permeability, but these are associated with adverse effects and are, therefore, not clinically applicable. We recently identified that combination drug treatment of mannitol and temozolomide improved BBB permeability in vitro. Here, we investigated whether this combination could increase the effectiveness of stem cell treatment in an animal model of chronic ischemic stroke...
May 15, 2018: Cytotherapy
https://www.readbyqxmd.com/read/29775852/biomimetic-magnetoelectric-nanocrystals-synthesized-by-polymerization-of-heme-as-advanced-nanomaterials-for-biosensing-application
#6
Jeong Eun Hyeon, Da Woon Jeong, Young Jin Ko, Seung Wook Kim, Chulhwan Park, Sung Ok Han
Regardless of the malaria disease risk, the malaria parasite Plasmodium falciparum has an interesting mechanism. During its growth within the red blood cell, toxic free heme is converted into an insoluble crystalline form called the malaria pigment, or hemozoin. In particular, natural hemozoin nanocrystals can provide multiple applications in biosensing fields for health care and diagnosis as similar to artificial metal nanoparticles. In this study, the heme was biologically synthesized and polymerized by Corynebacterium glutamicum and final polymer was applied as a biomimetic conductive biopolymer...
May 10, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29774484/effect-of-post-filter-anticoagulation-on-mortality-in-patients-with-cancer-associated-pulmonary-embolism
#7
Jieun Kang, Seon Ok Kim, Yeon-Mok Oh, Sang-Do Lee, Jae Seung Lee
BACKGROUND: Malignancy is associated with an increased risk of venous thromboembolism. Inferior vena cava filters are a viable alternative when anticoagulation is infeasible because of the risk of bleeding. Although the current guidelines recommend that all patients with a vena cava filter be treated with anticoagulation treatment when the risk of bleeding is reduced, studies concerning the role of concomitant anticoagulation after vena cava filter insertion in high-risk patients are scarce...
May 17, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29771787/point-of-care-cryptococcal-antigen-screening-pipetting-finger-prick-blood-improves-performance-of-immuno-mycologics-lateral-flow-assay
#8
Rachel M Wake, Joseph N Jarvis, Thomas S Harrison, Nelesh P Govender
BACKGROUND: Cryptococcal antigen (CrAg) screening at point of care could improve cryptococcal meningitis prevention where laboratory resources are limited. We evaluated the accuracy of Immuno-Mycologics (IMMY, Norman, OK) CrAg lateral flow assay (LFA) using different techniques at point of care. SETTING: Two tertiary-level hospitals in Johannesburg and a community health clinic in Soweto, South Africa. METHODS: A case-control diagnostic validation study, and a prospective clinic-based implementation study using the IMMY CrAg LFA on finger-prick blood...
April 30, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29764117/risk-factor-analysis-for-secondary-malignancy-in-dexrazoxane-treated-pediatric-cancer-patients
#9
Hyery Kim, Hyoung Jin Kang, Kyung Duk Park, Kyung-Nam Koh, Ho Joon Im, Jong Jin Seo, Jae Wook Lee, Nack-Gyun Chung, Bin Cho, Hack Ki Kim, Jae Min Lee, Jeong Ok Hah, Jun Ah Lee, Young Ho Lee, Sang Kyu Park, Hee Jo Baek, Hoon Kook, Ji Yoon Kim, Heung Sik Kim, Hwang Min Kim, Hee Won Chueh, Meerim Park, Hoi Soo Yoon, Mee Jeong Lee, Hyoung Soo Choi, Hyo Seop Ahn, Yoshifumi Kawano, Ji Won Park, Seokyung Hahn, Hee Young Shin
Purpose: Dexrazoxane has been used as an effective cardioprotector against anthracycline cardiotoxicity. This study intended to analyze cardioprotective efficacy and secondary malignancy development, and elucidate risk factors for secondary malignancies in dexrazoxane-treated pediatric patients. Materials and Methods: Data was collected from 15 hospitals in Korea. Patients who received any anthracyclines, and completed treatment without stem cell transplantation were included...
May 14, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29763308/variable-asymmetric-chains-in-transition-metal-oxyfluorides-structure-second-harmonic-generation-property-relationships
#10
Belal Ahmed, Hongil Jo, Seung-Jin Oh, Kang Min Ok
Four novel transition metal oxyfluorides, [Zn(pz)3 ][MoO2 F4 ]·0.1H2 O (1), [Zn(pz)2 F2 ][Zn(pz)3 ]2 [WO2 F4 ]2 (2), [Cd(pz)4 ][Cd(pz)4 (H2 O)][MoO2 F4 ]2 ·0.625H2 O (3), and [Zn(mpz)3 ]2 [MoO2 F4 ]2 (4) (pz = pyrazole; mpz = 3-methyl pyrazole) have been synthesized. Compounds 1 and 4 contain helical chains. Compound 2 accommodates zigzag chains, and compound 3 has quasi-one-dimensional linear chains. The variable chain structures are found to be attributable to the different structure-directing anionic groups and hydrogen bonding interactions...
May 15, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29762083/independent-risk-factors-for-the-shivering-occurrence-during-induction-period-in-out-of-hospital-cardiac-arrest-survivors-treated-with-targeted-temperature-management
#11
Youn-Jung Kim, Jin Mi Park, Min Soo Kim, Seung Mok Ryoo, Young Soon Park, Sung Sook Kim, Yeo Ok Kim, Won Young Kim
The occurrence of shivering during the induction period of targeted temperature management (TTM) remains a therapeutic obstacle, which delays the achievement of target temperature. The aim of this study was to identify risk factors leading to shivering during the induction period. We analyzed a prospective cohort of adult out-of-hospital cardiac arrest (OHCA) survivors treated with TTM from January 2015 to June 2017. Patients who developed shivering during the induction period were compared to those who did not...
May 15, 2018: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/29761660/feasibility-of-re-biopsy-and-egfr-mutation-analysis-in-patients-with-non-small-cell-lung-cancer
#12
Tae-Ok Kim, In-Jae Oh, Bo Gun Kho, Ha Young Park, Jin Sun Chang, Cheol-Kyu Park, Hong-Joon Shin, Jung-Hwan Lim, Yong-Soo Kwon, Yu-Il Kim, Sung-Chul Lim, Young-Chul Kim, Yoo-Duk Choi
BACKGROUND: In cases of EGFR-tyrosine kinase inhibitor (TKI) failure, re-biopsy may be useful to understand resistance mechanisms and guide further treatment decisions. However, performing re-biopsy is challenging because of several hurdles. We assessed the feasibility of re-biopsy in advanced non-small cell lung cancer (NSCLC) patients in real-world clinical practice. METHODS: We retrospectively reviewed the clinical and pathologic data of advanced NSCLC patients who experienced disease progression after previous treatment with EGFR-TKIs at a single tertiary hospital in Korea between January 2014 and December 2016...
May 14, 2018: Thoracic Cancer
https://www.readbyqxmd.com/read/29761609/rb3vo-o2-2co3-a-four-in-one-carbonatoperoxovanadate-exhibiting-extremely-strong-second-harmonic-generation-response
#13
Guohong Zou, Hongil Jo, Seong-Ji Lim, Tae-Soo You, Kang Min Ok
A novel nonlinear optical (NLO) carbonatoperoxovanadate, Rb3VO(O2)2CO3, was synthesized through a simple solution-evaporation method in phase pure form. Single-crystal X-ray diffraction revealed that the structure of Rb3VO(O2)2CO3 consists of important noncentrosymmetric (NCS) chromophores, i.e., π-delocalized (CO3)2- groups, second-order Jahn-Teller (SOJT) distortive V5+ cation, and π-localized distorted O22- groups, as well as charge balancing polarizable Rb+ ions. The powder second-harmonic generation (SHG) measurements indicated that Rb3VO(O2)2CO3 is phase-matchable (Type I) and exhibits a remarkably strong SHG response of approximately 21...
May 15, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29761411/detection-of-pathogenic-viruses-in-the-ambient-air-in-seoul-korea
#14
Tae-Hee Han, Sang-Hun Park, Ju-Young Chung, Hyo-Won Jeong, Jihun Jung, Jae-In Lee, Young-Ok Hwang, Il-Young Kim, Jip-Ho Lee, Kweon Jung
The possible transport of pathogenic microorganisms during Asian dust events could be an important concern for health workers; however, this is still uncertain owing to a lack of supporting evidence. The present study aimed to investigate the presence of pathogenic microorganisms in air samples collected during the Asian and non-Asian dust periods. Between March and September 2016, air samples were collected at three weather observation stations in Seoul using a high-volume air sampler. Multiplex PCR was performed using the Allplex™ respiratory and gastrointestinal panel assay kits to detect 46 microorganisms...
May 14, 2018: Food and Environmental Virology
https://www.readbyqxmd.com/read/29760708/dual-tlr2-9-recognition-of-herpes-simplex-virus-infection-is-required-for-recruitment-and-activation-of-monocytes-and-nk-cells-and-restriction-of-viral-dissemination-to-the-central-nervous-system
#15
Erdenebileg Uyangaa, Jin Young Choi, Ajit Mahadev Patil, Ferdaus Mohd Altaf Hossain, Sung Ok Park, Bumseok Kim, Koanhoi Kim, Seong Kug Eo
The importance of TLR2 and TLR9 in the recognition of infection with herpes simplex virus (HSV) and HSV-caused diseases has been described, but some discrepancies remain concerning the benefits of these responses. Moreover, the impact of TLR2/9 on innate and adaptive immune responses within relevant mucosal tissues has not been elucidated using natural mucosal infection model of HSV. Here, we demonstrate that dual TLR2/9 recognition is essential to provide resistance against mucosal infection with HSV via an intravaginal route...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29756265/web-based-thyroid-imaging-reporting-and-data-system-malignancy-risk-of-atypia-of-undetermined-significance-or-follicular-lesion-of-undetermined-significance-thyroid-nodules-calculated-by-a-combination-of-ultrasonography-features-and-biopsy-results
#16
Young Jun Choi, Jung Hwan Baek, Jung Hee Shin, Woo Hyun Shim, Seon-Ok Kim, Won-Hong Lee, Dong Eun Song, Tae Yong Kim, Ki-Wook Chung, Jeong Hyun Lee
BACKGROUND: The purpose of this study was to construct a web-based predictive model using ultrasound characteristics and subcategorized biopsy results for thyroid nodules of atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) to stratify the risk of malignancy. METHODS: Data included 672 thyroid nodules from 656 patients from a historical cohort. We analyzed ultrasound images of thyroid nodules and biopsy results according to nuclear atypia and architectural atypia...
May 13, 2018: Head & Neck
https://www.readbyqxmd.com/read/29754058/plant-and-soil-responses-to-hydrothermally-converted-sewage-sludge-sewchar
#17
Tatiane Medeiros Melo, Michael Bottlinger, Elke Schulz, Wilson Mozena Leandro, Adelmo Menezes de Aguiar Filho, Hailong Wang, Yong Sik Ok, Jörg Rinklebe
This study compared the effects of sewchar and mineral fertilizer on plant responses in beans (Phaseolus vulgaris, var. "Jalo precoce") and soil properties in a pot experiment in a completely randomized design with two harvests. The initial treatments consisted of a control, sewchar doses of 4, 8, 16 and 32 Mg ha-1 and mineral fertilizer (30 mg N, 90 mg P2 O5 and 60 mg K2 O kg-1 ). The treatments (4 replications each) were fertilized with 135 mg P2 O5  kg-1 at the second harvest. The sewchar application rates correlated positively with the CEC, the water holding capacity, the availability of Zn, Ca, Fe, Cu, and P, and the concentrations of nitrate, ammonium, total N, total organic carbon and hot water extractable carbon...
May 2, 2018: Chemosphere
https://www.readbyqxmd.com/read/29753657/irf-1-rig-i-and-mda5-display-potent-antiviral-activities-against-norovirus-coordinately-induced-by-different-types-of-interferons
#18
Wen Dang, Lei Xu, Yuebang Yin, Sunrui Chen, Wenshi Wang, Mohamad S Hakim, Kyeong-Ok Chang, Maikel P Peppelenbosch, Qiuwei Pan
Norovirus represents the main cause of acute nonbacterial gastroenteritis worldwide. In immunocompromised patients, it bears high risk of causing chronic infection with significant morbidity and mortality. The lack of specific treatment prompts the development of anti-norovirus agents. In this study, we have investigated the role of interferon (IFN) response and evaluated antiviral activities of different IFNs against human norovirus (HuNoV) replication using a HuNoV replicon model. We found that HuNoV RNA replication was sensitive to all types of IFNs, including IFNα (type I), IFNγ (type II), IFNλ1 and 3 (type III)...
May 10, 2018: Antiviral Research
https://www.readbyqxmd.com/read/29752060/age-related-hearing-loss-and-its-association-with-depression-in-later-life
#19
Katharine K Brewster, Adam Ciarleglio, Patrick J Brown, Chen Chen, Hae-Ok Kim, Steven P Roose, Justin S Golub, Bret R Rutherford
OBJECTIVES: To evaluate the association between age-related hearing loss (ARHL) and depressive symptoms in older adults over time. METHODS: Data from the Health Aging and Body Composition study (N = 3075, aged 70-79 at baseline) were used previously to conduct a longitudinal latent class analysis to evaluate depression trajectories (Center for Epidemiologic Studies Depression [CES-D] Scale) over 10 years. Restricting to the subset of subjects who had hearing information available (N = 1204), self-reported hearing categories were evaluated over the same period...
April 13, 2018: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29750425/increased-infiltration-of-macrophages-to-radioresistant-lung-cancer-cells-contributes-to-the-development-of-the-additional-resistance-of-tumor-cells-to-the-cytotoxic-effects-of-nk-cells
#20
Mingjing Shen, Yongbing Chen, Lijun Xu, Rongying Zhu, Xiang Xue, Ying Tsai, Peter C Keng, Soo Ok Lee, Yuhchyau Chen
In this study, in order to investigate the effects of increased macrophage infiltration to radioresistant lung tumors in regulating natural killer (NK) cell-mediated immunity, we examined whether the treatment of radioresistant cells with conditioned medium (CM) from phorbol myristate acetate (PMA)/interleukin (IL)-4 treated THP-1 cells (used as a tumor-associated macrophage source) leads to the development of the additional resistance of tumor cells to NK cell cytotoxicity. We found that the susceptibility of THP-1 CM-treated radioresistant cells to NK cell cytotoxicity was decreased compared to the non-treated cells...
May 4, 2018: International Journal of Oncology
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