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https://www.readbyqxmd.com/read/28548546/the-risk-of-herpes-zoster-in-patients-with-ankylosing-spondylitis-analysis-of-the-korean-national-health-insurance-service-sample-cohort-database
#1
Doo-Ho Lim, Ye-Jee Kim, Seon Ok Kim, Seokchan Hong, Chang-Keun Lee, Bin Yoo, Yong-Gil Kim
OBJECTIVES: The aims of our study were to determine whether the use of conventional disease-modifying antirheumatic drugs (cDMARDs) or tumor necrosis factor α (TNFα) inhibitors increase the risk of herpes zoster (HZ) in patients with ankylosing spondylitis (AS). METHODS: We searched the South Korean National Health Insurance Service - National Sample Cohort Database for relevant patient records between 2002 and 2013. We evaluated the incidence of HZ by categorizing patients into in three treatment groups: disease-modifying antirheumatic drug (DMARD) nonusers, cDMARD users and TNFα inhibitor users...
May 26, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28545323/an-efficient-phosphorus-scavenging-from-aqueous-solution-using-magnesiothermally-modified-bio-calcite
#2
Munir Ahmad, Mahtab Ahmad, Adel R A Usman, Abdullah S Al-Faraj, Yong Sik Ok, Qaiser Hussain, Adel Abduljabbar, Mohammad I Al-Wabel
The excessive discharge of phosphorus (P) from sewage treatment plants and runoff from agricultural fields is causing a rapid contamination of water resources worldwide. Several materials have been evaluated for the removal of excess P from waste supplies, but designing a cost-effective and environmental friendly substrate is essential for the efficient P removal. In this study, bio-calcite (BC) derived from waste hen eggshell was subjected to thermal treatments (CBC). The BC and CBC further modified via magnesiothermal treatments to produced MBC and MCBC, respectively, and evaluated as a novel green sorbent for P removal from aqueous solutions...
May 26, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28544768/examining-practical-nursing-experiences-to-discover-ways-in-which-to-retain-and-invigorate-the-remaining-functions-of-the-elderly-with-a-demented-and-complex-disability-in-nursing-homes
#3
Min-Sun Park, Sun-Young Lim, Eun-Young Kim, Su-Jung Lee, Sung-Ok Chang
AIM: The bedridden elderly with moderate-to-severe dementia account for a large proportion of the residents in nursing homes and form a specialized group requiring customized care in order to encourage their remaining functions, which determine the quality of their residual life. The purpose of this study was to search for ways to invigorate and foster the remaining functions of this complex-disability group, based on practical nursing strategies in nursing homes. METHODS: The qualitative thematic analysis was done by conducting in-depth interviews with 29 nurses working at 11 different nursing homes in South Korea...
May 23, 2017: Japan Journal of Nursing Science: JJNS
https://www.readbyqxmd.com/read/28544463/axonal-charcot-marie-tooth-neuropathy-concurrent-with-distal-and-proximal-weakness-by-translational-elongation-of-the-3-utr-in-nefh
#4
Da Eun Nam, Sung-Chul Jung, Da Hye Yoo, Sun Seong Choi, Sung-Yum Seo, Gwang Hoon Kim, Song-Ja Kim, Soo Hyun Nam, Byung-Ok Choi, Ki Wha Chung
Mutations in the NEFH gene encoding the heavy neurofilament protein are usually associated with neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS). Recently, frameshift variants in NEFH (p.Asp1004Glnfs*58 and p.Pro1008Alafs*56) have been reported to be the underlying cause of axonal Charcot-Marie-Tooth disease type 2CC (CMT2CC). The frameshift mutation resulted in a stop loss and translation of a cryptic amyloidogenic element (CAE) encoded by the 3' UTR. This study also identified a de novo c...
May 24, 2017: Journal of the Peripheral Nervous System: JPNS
https://www.readbyqxmd.com/read/28544095/phenotypic-assays-for-mycobacterium-tuberculosis-infection
#5
Ok-Ryul Song, Nathalie Deboosere, Vincent Delorme, Christophe J Queval, Gaspard Deloison, Elisabeth Werkmeister, Frank Lafont, Alain Baulard, Raffaella Iantomasi, Priscille Brodin
Tuberculosis (TB) is still a major global threat, killing more than one million persons each year. With the constant increase of Mycobacterium tuberculosis strains resistant to first- and second-line drugs, there is an urgent need for the development of new drugs to control the propagation of TB. Although screenings of small molecules on axenic M. tuberculosis cultures were successful for the identification of novel putative anti-TB drugs, new drugs in the development pipeline remains scarce. Host-directed therapy may represent an alternative for drug development against TB...
May 19, 2017: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
https://www.readbyqxmd.com/read/28543863/prmt8-controls-the-pluripotency-and-mesodermal-fate-of-human-embryonic-stem-cells-by-enhancing-the-pi3k-akt-sox2-axis
#6
Ho-Chang Jeong, Soon-Jung Park, Jong-Jin Choi, Young-Hyun Go, Soon-Ki Hong, Ok-Seon Kwon, Joong-Gon Shin, Rae-Kwon Kim, Mi-Ok Lee, Su-Jae Lee, Hyoung Doo Shin, Sung-Hwan Moon, Hyuk-Jin Cha
Basic fibroblast growth factor (bFGF) supplementation is critical to maintain the pluripotency of human pluripotent stem cells (hPSCs) through activation of PI3K/AKT, rather than MEK/ERK pathway. Thus, elaborate molecular mechanisms that preserve PI3K/AKT signaling upon bFGF stimulation may exist in hPSCs. Protein arginine methyltransferases 8 (PRMT8) was expressed and then its level gradually decreased during spontaneous differentiation of human embryonic stem cells (hESCs). PRMT8 loss- or gain-of-function studies demonstrated that PRMT8 contributed to longer maintenance of hESC pluripotency, even under bFGF-deprived conditions...
May 20, 2017: Stem Cells
https://www.readbyqxmd.com/read/28542415/pharmacological-thromboprophylaxis-and-its-impact-on-venous-thromboembolism-following-total-knee-and-hip-arthroplasty-in-korea-a-nationwide-population-based-study
#7
Ho-Young Yhim, Juhyun Lee, Ji Yun Lee, Jeong-Ok Lee, Soo-Mee Bang
BACKGROUND: Limited data is available regarding the pharmacological prophylaxis for venous thromboembolism (VTE) in Asian patients undergoing total knee arthroplasty or total hip arthroplasty (TKA/THA). METHODS: We performed a population-based epidemiological study using the Health Insurance Review and Assessment Service database to estimate the rate of pharmacological thromboprophylaxis and its impact on VTE in Korean patients who underwent TKA/THA between 2009 and 2013...
2017: PloS One
https://www.readbyqxmd.com/read/28541627/sentinel-lymph-node-mapping-with-indocyanine-green-in-vaginal-cancer
#8
In Ok Lee, Jung Yun Lee, Sunghoon Kim, Sang Wun Kim, Young Tae Kim, Eun Ji Nam
OBJECTIVE: Sentinel lymph node (SLN) mapping is being adapted to gynecologic cancer. Higher SLN mapping rates were reported with indocyanine green (ICG) compared to other dyes. The aim of this film is to share our experience of SLN mapping with ICG in vaginal cancer. METHODS: A 40 year-old woman was diagnosed with squamous cell vaginal cancer. About 1.5 cm-sized tumor was located on the posterior vaginal fornix. Preoperatively she was assumed to be stage I vaginal cancer...
July 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/28541244/parotid-gland-tumors-results-of-retrospective-analysis-of-149-patients-treated-at-the-clinical-department-of-cranio-maxillofacial-surgery-clinic-of-otolaryngology-and-oncologic-laryngology-of-military-institute-of-medicine-in-warsaw-in-years-2006-2016
#9
Aldona Chloupek, Krzysztof Zarzycki, Jarosław Dąbrowski, Wojciech Domański
Wstęp: Nowotwory mające swoją etiologię w gruczołach ślinowych występują rzadko i stanowią ok. 3-10% wszystkich guzów w obrębie głowy i szyi. Materiał i metody: W latach 2006-2016 w Klinicznym Oddziale Chirurgii Czaszkowo-Szczękowo-Twarzowej Wojskowego Instytutu Medycznego w Warszawie z powodu nowotworów ślinianek przyusznych hospitalizowano i leczono 149 pacjentów. Podstawą do analizy były historie chorób pacjentów, wyniki badań histopatologicznych oraz protokoły zabiegów operacyjnych...
June 30, 2017: Otolaryngologia Polska
https://www.readbyqxmd.com/read/28540275/awareness-and-work-changes-of-dental-hygienists-about-newly-covering-health-insurance-benefit-for-scaling
#10
Yu-Ri Choi, Youn-Soo Shim, Sun-Ok Jang, Seoul-Hee Nam, Gyeong-Soon Han
No abstract text is available yet for this article.
April 2017: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/28535611/sea-buckthorn-hippophae-rhamnoides-l-leaf-extracts-protect-neuronal-pc-12-cells-from-oxidative-stress
#11
Chi Heung Cho, Ho Lim Jang, Migi Lee, Hee Kang, Ho Jjn Heo, Dae-Ok Kim
The present study was carried out to investigate the antioxidative and neuroprotective effects of sea buckthorn (Hippophae rhamnoides L.) leaves (SBL) harvested at different times. Reversed-phase high-performance liquid chromatography analysis revealed five major phenolic compounds: ellagic acid, gallic acid, isorhamnetin, kaempferol, and quercetin. SBL harvested in August had the highest total phenolic and flavonoid contents and antioxidant capacity. Treatment of neuronal PC-12 cells with the ethyl acetate fraction of SBL harvested in August in increased their viability and membrane integrity and reduced intracellular oxidative stress in a dose-dependent manner...
May 24, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28534925/osmotin-loaded-magnetic-nanoparticles-with-electromagnetic-guidance-for-the-treatment-of-alzheimer-s-disease
#12
Faiz Ul Amin, Ali Kafash Hoshiar, Ton Duc Do, Yeongil Noh, Shahid Ali Shah, Muhammad Sohail Khan, Jungwon Yoon, Myeong Ok Kim
Alzheimer's disease (AD) is the most prevalent age-related neurodegenerative disease, pathologically characterized by the accumulation of aggregated amyloid beta (Aβ) in the brain. Here, we describe for the first time the development of a new, pioneering nanotechnology-based drug delivery approach for potential therapies for neurodegenerative diseases, particularly AD. We demonstrated the delivery of fluorescent carboxyl magnetic Nile Red particles (FMNPs) to the brains of normal mice using a functionalized magnetic field (FMF) composed of positive- and negative-pulsed magnetic fields generated by electromagnetic coils...
May 23, 2017: Nanoscale
https://www.readbyqxmd.com/read/28533187/host-directed-therapies-offer-novel-opportunities-for-the-fight-against-tuberculosis
#13
REVIEW
Arnaud Machelart, Ok-Ryul Song, Eik Hoffmann, Priscille Brodin
Tuberculosis (TB) remains a leading global health problem that is exacerbated by the emergence of multidrug and extensively drug-resistant Mycobacterium tuberculosis strains. Control of the disease requires novel therapeutic strategies. Modulating host homeostasis appears to be a promising approach, and recent studies have identified novel potential host targets and compounds that could be investigated for host-directed therapies (HDTs). Moreover, the recent development of intracellular high-throughput phenotypic assays makes it possible to screen large libraries of compounds to identify more rapidly new effectors for mycobacterial elimination...
May 19, 2017: Drug Discovery Today
https://www.readbyqxmd.com/read/28532290/midlife-women-s-cardiovascular-symptoms-a-cluster-analysis
#14
Eun-Ok Im, Young Ko, Eunice Chee, Wonshik Chee, Jun James Mao
Menopausal transition, in which biological and psychosocial changes are caused due to estrogen fluctuations, has been reported to increase cardiovascular risk among midlife women. Our purpose of this study was to identify the clusters of midlife women by cardiovascular symptoms and to examine racial/ethnic differences in the clusters. This was a secondary analysis, in which hierarchical cluster and multinomial logistic analyses were conducted with the data (N = 966) collected in two previous studies. Three-clusters were adopted: Cluster 1 (high vasomotor and low cardiorespiratory), Cluster 2 (low vasomotor and high cardiorespiratory and high discomfort/pain), and Cluster 3 (high discomfort/pain and high indigestion)...
May 22, 2017: Health Care for Women International
https://www.readbyqxmd.com/read/28531919/bupleurum-chinense-extract-ameliorates-an-ova-induced-murine-allergic-asthma-through-the-reduction-of-the-th2-and-th17-cytokines-production-by-inactivation-of-nf%C3%AE%C2%BAb-pathway
#15
Thi Tho Bui, Chun Hua Piao, Chang Ho Song, Hee Soon Shin, Ok Hee Chai
Bupleurum chinense belongs to the Bupleurum spp. family that has been used in traditional herbal medicine for over thousand years. It has been reported to have anti-inflammatory, anti-oxidant, hepato-protective, antipyretic, analgesic, anti-fibrotic and immunomodulatory effect. However, the effect of B. Chinense on allergic asthma remains unclear. This study investigated the immunomodulatory effects of B. Chinense extracts (BCE) on airway inflammation in asthmatic mice model. In the ovalbumin (OVA)-induced allergic asthma model, we evaluated the number of total cells, differential inflammatory cells and the production of proinflammatory cytokines in bronchoalveolar lavage fluid (BALF) and lung homogenate as well as histological structure...
May 16, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28530736/magnetic-field-controlled-graphene-oxide-based-origami-with-enhanced-surface-area-and-mechanical-properties
#16
Ok-Kyung Park, Chandra Sekhar Tiwary, Yang Yang, Sanjit Bhowmick, Soumya Vinod, Qingbo Zhang, Vicki L Colvin, S A Syed Asif, Robert Vajtai, Evgeni S Penev, Boris I Yakobson, Pulickel M Ajayan
One can utilize the folding of paper to build fascinating 3D origami architectures with extraordinary mechanical properties and surface area. Inspired by the same, the morphology of 2D graphene can be tuned by addition of magnetite (Fe3O4) nanoparticles in the presence of a magnetic field. The innovative 3D architecture with enhanced mechanical properties also shows a high surface area (∼2500 m(2) g(-1)) which is utilized for oil absorption. Detailed microscopy and spectroscopy reveal rolling of graphene oxide (GO) sheets due to the magnetic field driven action of magnetite particles, which is further supported by molecular dynamics (MD) simulations...
May 22, 2017: Nanoscale
https://www.readbyqxmd.com/read/28529841/rapid-and-conformal-coating-of-polymer-resins-by-airbrushing-for-continuous-and-high-speed-roll-to-roll-nanopatterning-parametric-quality-controls-and-extended-applications
#17
Jae Hyuk Lee, Minho Na, Jiyeop Kim, Kangeun Yoo, Jaekyu Park, Jeong Dae Kim, Dong Kyo Oh, Seungjo Lee, Hongseok Youn, Moon Kyu Kwak, Jong G Ok
We present a facile and scalable coating method based on controlled airbrushing, which is suitable for conformal resin coating in continuous roll-to-roll (R2R) nanoimprint lithography (NIL) process. By controlling the concentration of UV-curable polymeric resin with mixing the volatile solvent and its airbrushing time, the coated resin film thickness can be readily tuned. After R2R NIL using a flexible nanoscale line pattern (nanograting) mold is conducted upon the airbrushed resin film, a large-area uniform nanograting pattern is fabricated with controlled residual layer thickness (RLT) based on the initial film thickness...
2017: Nano Convergence
https://www.readbyqxmd.com/read/28528310/comparative-analysis-of-speciation-and-bioaccessibility-of-arsenic-in-rice-grains-and-complementary-medicines
#18
S Bolan, A Kunhikrishnan, S Chowdhury, B Seshadri, R Naidu, Y S Ok
In many countries, rice grains and complementary medicines are important sources of arsenic (As) consumption. The objective of this study was to compare the speciation and bioaccessibility of As in selected rice grains and complementary medicines. A number of rice grain samples, and a range of herbal and ayurvedic medicines were analyzed for total As, speciation of As using sequential fractionation and extended x-ray absorption fine structure (EXAFS) techniques, and bioaccessibility of As using an in vitro extraction test...
May 3, 2017: Chemosphere
https://www.readbyqxmd.com/read/28525829/epidemiology-and-management-of-primary-immune-thrombocytopenia-a-nationwide-population-based-study-in-korea
#19
Ji Yun Lee, Ju-Hyun Lee, Heeyoung Lee, Beodeul Kang, Ji-Won Kim, Se Hyun Kim, Jeong-Ok Lee, Jin Won Kim, Yu Jung Kim, Keun-Wook Lee, Jee Hyun Kim, Hyoung Soo Choi, Jong Seok Lee, Soo-Mee Bang
INTRODUCTION: The epidemiology of immune thrombocytopenia (ITP) is not well characterized in an Asian population. MATERIALS AND METHODS: From July 2010 to June 2014, ITP patients were identified using the Korean Health Insurance Review and Assessment Service database. RESULTS: The overall incidence rate of ITP was 5.3 per 100,000 person-years (95% CI: 5.1-5.5). The overall incidence rate ratios of children under 15years old to adults and females to males were 3...
May 11, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28523212/rapid-collection-of-opinions-from-healthcare-professionals-in-multiple-institutions-using-short-message-service-and-google-forms
#20
Wonwoong Lee, Soo-Yong Shin, Dong-Woo Seo, Chang Hwan Sohn, Jeong Min Ryu, Jae Ho Lee, Won Young Kim, Bum Jin Oh, Sung Ok Hong, Kyoung Soo Lim
No abstract text is available yet for this article.
April 2017: Healthcare Informatics Research
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