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https://www.readbyqxmd.com/read/28088523/the-selective-cysteinyl-leukotriene-receptor-1-cyslt1r-antagonist-montelukast-regulates-extracellular-matrix-remodeling
#1
Jingli Peng, Hezheng Zhou, Guoping Kuang, Lilian Xie, Tao Tian, Ru Liu
Scar formation after filtration surgery of glaucoma is mainly caused by excessive synthesis of new extracellular matrix (ECM) and contraction of subconjunctival tissue mediated by human Tenon fibroblasts (HTFs) and the transforming growth factor (TGF-β1). Montelukast, a potent and specific cysteinyl leukotriene receptor 1 (cysLT1R) antagonist, is a licensed drug clinically used for the treatment of bronchial asthma. In this study, we investigated the effects of montelukast on the contractility of HTFs cultured in a three-dimensional collagen gel...
January 11, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28087926/urinary-tract-infections-in-infants-and-children
#2
Theresa A Schlager
Urinary tract infections (UTI) are one of the most common infections in children and symptoms may be nonspecific. The risk of renal scarring is highest in children under 1 year of age with febrile UTI and high-grade vesicoureteral reflux (VUR). Although treatment of UTI is usually straightforward, given increased rates of antimicrobial resistance worldwide, the choice of treatment for pediatric UTI should be guided by community resistance patterns whenever feasible. The benefit of antimicrobial prophylaxis after first UTI and/or in the presence of VUR remains controversial, but a recent meta-analysis supports continuous antimicrobial prophylaxis in children with VUR, indicating a need for more research in this area...
October 2016: Microbiology Spectrum
https://www.readbyqxmd.com/read/28087230/the-impact-of-obesity-on-febrile-urinary-tract-infection-and-renal-scarring-in-children-with-vesicoureteral-reflux
#3
H J Byun, J Y Ha, W Jung, B H Kim, C H Park, C I Kim
INTRODUCTION: It has become clear that obesity is associated with a variety of infectious diseases, including urinary tract infection (UTI) and renal scarring. OBJECTIVE: The aim of this study was to evaluate the association between obesity and the degree of febrile UTI (fUTI) and renal scarring in children with vesicoureteral reflux (VUR), and to stratify the results into obesity subcategories. STUDY DESIGN: A total of 186 patients were diagnosed with VUR between January 2002 and December 2008...
October 1, 2016: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28076744/modern-management-of-acne
#4
Alan J Cooper, Victoria Rebecca Harris
Acne is a chronic inflammatory disease of the pilosebaceous unit resulting from androgen-induced increased sebum production; altered keratinisation; bacterial colonisation of hair follicles on the face, neck, chest and back by Propionibacterium acnes; and an inflammatory response in the skin. The exact way these processes interact and the order in which they occur in the pathogenesis of acne are still unclear. Scarring that occurs from acne, particularly severe acne, can persist a lifetime and have long lasting psychosocial effects...
January 16, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/28075443/microrna-expression-signature-and-the-therapeutic-effect-of-the-microrna%C3%A2-21-antagomir-in-hypertrophic-scarring
#5
Liang Guo, Kai Xu, Hongbo Yan, Haifeng Feng, Tao Wang, Linlin Chai, Guozheng Xu
Hypertrophic scars (HS) area fibroproliferative disorder of the skin, which causes aesthetic and functional impairment. However, the molecular pathogenesis of this disease remains largely unknown and currently no efficient treatment exists. MicroRNAs (miRNAs) are involved in a variety of pathophysiological processes, however the role of miRNAs in HS development remains unclear. To investigate the miRNA expression signature of HS, microarray analysis was performed and 152 miRNAs were observed to be differentially expressed in HS tissue compared with normal skin tissues...
January 5, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28074719/-ten-tips-for-initial-assessment-and-treatment-of-minor-burns
#6
G L Vlaspolder, A F P M Vloemans, R S Breederveld
The initial care of a patient with burns is a challenge for every doctor. After cooling the burn appropriately, a careful history and a good initial assessment are of essential importance for treatment. The burn should be inspected regularly for early detection of any infection and to evaluate wound healing. If healing has not occurred in two weeks, hypertrophic scarring may develop and surgical treatment should be considered. It is always possible to contact the burns centres in Beverwijk, Rotterdam and Groningen to discuss treatment of the burn, any infection of a wound, consideration of surgical treatment, or transfer of a patient to a burn centre...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28070045/-effect-of-calcium-channel-blockers-on-primary-cultured-human-urethra-scar-fibroblasts
#7
Mingqiang Zeng, Junjie Chen, Liang Huang, Ruizhi Xue, Xuyu Xiang, Fanchang Zeng, Guilin Wang, Zhengyan Tang
To investigate effects of verapamil on primary cultured human urethral scar fibroblasts (USFs) and to provide basis for protecting the formation of urethra scar.
 Methods: The cell proliferation was evaluated with the cell counting kit (CCK)-8 method after USFs were incubated various verapamil concentrations (50, 100, 150, 200, or 250 μmol/L) or solvent for 12, 24, or 48 h. The protein level of matrix metalloproteinase (MMP) was evaluated with ELISA after cells were incubated with verapamil (100 μmol/L) or solvent (control cells) for 24 h...
December 28, 2016: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28069270/treatment-of-subcutaneous-abscesses-in-children-with-incision-and-loop-drainage-a-simplified-method-of-care
#8
Charles J Aprahamian, Hilana Nashad, Nerina DiSomma, Breanna Elger, Joseph Esparaz, Thomas McMorrow, Alexandria Shadid, Angie Kao, Mark J Holterman, Robert C Kanard, Richard H Pearl
PURPOSE: The aim of this study was to expand on our previous report of 115 patients after more than a decade-long experience using incision and loop drainage for pediatric subcutaneous abscess management. This report comprises the largest consecutive series of pediatric abscess patients from a single institution ever recorded. METHODS: A retrospective study was performed of all pediatric patients who underwent incision and loop drainage of subcutaneous abscesses at our institution between January 2002 and December 2014...
December 30, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28065861/targeting-and-modulating-infarct-macrophages-with-hemin-formulated-in-designed-lipid-based-particles-improves-cardiac-remodeling-and-function
#9
Tamar Ben-Mordechai, David Kain, Radka Holbova, Natalie Landa, La-Paz Levin, Inbar Elron-Gross, Yifat Glucksam-Galnoy, Micha S Feinberg, Rimona Margalit, Jonathan Leor
Uncontrolled activation of pro-inflammatory macrophages after myocardial infarction (MI) accelerates adverse left ventricular (LV) remodeling and dysfunction. Hemin, an iron-containing porphyrin, activates heme oxygenase-1 (HO-1), an enzyme with anti-inflammatory and cytoprotective properties. We sought to determine the effects of hemin formulated in a macrophage-targeted lipid-based carrier (denoted HA-LP) on LV remodeling and function after MI. Hemin encapsulation efficiency was ~100% at therapeutic dose levels...
January 5, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28064433/magnetic-vt-study-a-prospective-multicenter-post-market-randomized-controlled-trial-comparing-vt-ablation-outcomes-using-remote-magnetic-navigation-guided-substrate-mapping-and-ablation-versus-manual-approach-in-a-low-lvef-population
#10
Luigi Di Biase, Roderick Tung, Tamás Szili-Torok, J David Burkhardt, Peter Weiss, Rene Tavernier, Adam E Berman, Erik Wissner, William Spear, Xu Chen, Petr Neužil, Jan Skoda, Dhanunjaya Lakkireddy, Bruno Schwagten, Ken Lock, Andrea Natale
PURPOSE: Patients with ischemic cardiomyopathy (ICM) are prone to scar-related ventricular tachycardia (VT). The success of VT ablation depends on accurate arrhythmogenic substrate localization, followed by optimal delivery of energy provided by constant electrode-tissue contact. Current manual and remote magnetic navigation (RMN)-guided ablation strategies aim to identify a reentry circuit and to target a critical isthmus through activation and entrainment mapping during ongoing tachycardia...
January 7, 2017: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/28063718/second-date-appendectomy-operating-for-failure-of-nonoperative-treatment-in-perforated-appendicitis
#11
Marco Lotti
BACKGROUND: Nonoperative treatment of acute appendicitis is embraced by many surgical teams, driven by low to moderate quality randomized studies that support noninferiority of antibiotics versus appendectomy for treatment of acute uncomplicated appendicitis. Several flaws of these studies have emerged, especially in the recruitment strategy and in the diagnostic criteria that were used. The growing confidence given to antibiotics, together with the lack of reliable criteria to distinguish between uncomplicated and perforated appendicitis, exposes patients with perforated appendicitis to the likelihood to be treated with antibiotics instead of surgery...
January 2, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28061361/comparison-of-the-retroauricular-approach-and-transcervical-approach-for-excision-of-a-second-brachial-cleft-cyst
#12
Dongbin Ahn, Gil Joon Lee, Jin Ho Sohn
PURPOSE: Although a retroauricular (RA) approach has been proposed for excision of a second brachial cleft cyst (BCC), no studies have performed a direct comparison of the results of the RA approach and those of the conventional transcervical approach. We evaluated the surgical outcomes of the RA approach under direct vision and demonstrate its benefits compared with the conventional transcervical approach for excision of a second BCC. PATIENTS AND METHODS: From January 2012 to May 2016, we enrolled 30 consecutive patients with a second BCC who underwent surgical excision as a primary treatment into the present prospective case-control study...
December 15, 2016: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28058953/use-of-a-subdermal-plexus-flap-to-reconstruct-an-upper-eyelid-following-radical-tumor-resection-in-a-cat
#13
Filipe C Dias, Alan Danielski, Kate Forster, David L Williams
CASE DESCRIPTION A 15-year-old neutered male domestic shorthair cat was examined for treatment of a recurrent neoplastic mass in the left upper eyelid that had been excised 6 months earlier by the referring veterinarian. CLINICAL FINDINGS An apparently nonpainful firm cutaneous mass (approx 2 × 2 mm) was located on the lateral third of the left upper eyelid near the scar from the previous surgical excision. TREATMENT AND OUTCOME Approximately one-third of the left upper lip was used as a subdermal plexus (lip-to-lid) flap to cover the defect created by en bloc excision of the eyelid mass...
January 15, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/28058163/clinical-features-and-course-of-patients-with-peripheral-exudative-hemorrhagic-chorioretinopathy
#14
Zafer Cebeci, Yasemin Dere, Şerife Bayraktar, Samuray Tuncer, Nur Kır
OBJECTIVES: To evaluate the clinical characteristics of patients who were followed in our clinic with the diagnosis of peripheral exudative hemorrhagic chorioretinopathy (PEHC). MATERIALS AND METHODS: Medical records of 12 patients who were diagnosed with PEHC in İstanbul University İstanbul Faculty of Medicine, Department of Ophthalmology between July 2006 and June 2014 were reviewed retrospectively. RESULTS: This study included 21 eyes of 12 patients...
October 2016: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28057555/reactive-astrogliosis-in-stroke-contributions-of-astrocytes-to-recovery-of-neurological-function
#15
REVIEW
Neil R Sims, Wai Ping Yew
Alterations in neuronal connectivity, particularly in the "peri-infarct" tissue adjacent to the region of ischemic damage, are important contributors to the spontaneous recovery of function that commonly follows stroke. Peri-infarct astrocytes undergo reactive astrogliosis and play key roles in modulating the adaptive responses in neurons. This reactive astrogliosis shares many features with that induced by other forms of damage to the central nervous system but also differs in details that potentially influence neurological recovery...
January 2, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28057125/-treatment-and-outcome-of-polypropylene-mesh-or-tape-related-pain-after-reconstructive-pelvic-surgery
#16
Y Q Wang, X Yang, J L Wang
Objective: To investigate clinical treatment and outcome of mesh-related pain after pelvic floor reconstruction. Methods: Twelve patients were referred to Peking University People's Hospital for post-operation pain related to polypropylene mesh or tape used in pelvic floor reconstruction and received reoperation from January 2007 to December 2014. The demographic characteristics, clinical manifestation, operation method and follow-up outcome were retrospectively analyzed, and current literature was also reviewed...
December 25, 2016: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/28056790/immunization-with-neural-derived-peptides-plus-scar-removal-induces-a-permissive-microenvironment-and-improves-locomotor-recovery-after-chronic-spinal-cord-injury
#17
Roxana Rodríguez-Barrera, Adrián Flores-Romero, Ana María Fernández-Presas, Elisa García-Vences, Raúl Silva-García, Mina Konigsberg, Liliana Blancas-Espinoza, Vinnitsa Buzoianu-Anguiano, Karla Soria-Zavala, Paola Suárez-Meade, Antonio Ibarra
BACKGROUND: Immunization with neural derived peptides (INDP) as well as scar removal-separately-have shown to induce morphological and functional improvement after spinal cord injury (SCI). In the present study, we compared the effect of INDP alone versus INDP with scar removal on motor recovery, regeneration-associated and cytokine gene expression, and axonal regeneration after chronic SCI. Scar removal was conducted through a single incision with a double-bladed scalpel along the stump, and scar renewal was halted by adding α,α'-dipyridyl...
January 5, 2017: BMC Neuroscience
https://www.readbyqxmd.com/read/28056485/evidence-of-invasive-and-non-invasive-treatment-modalities-for-hypertrophic-scars-a-systematic-review
#18
Mona Kafka, Vanessa Collins, Lars-Peter Kamolz, Thomas Rappl, Ludwik K Branski, Paul Wurzer
Currently, there are various therapeutic approaches to reduce hypertrophic scarring, however, there is no standard evidence-based treatment protocol. Hence, we performed a systematic review to obtain a summary of the latest clinical trials to evaluate evidence for the treatment of hypertrophic scars. The review protocol was registered and approved by PROSPERO (CRD42015027040). PubMed and Web of Science were searched using predefined MeSH-Terms to identify studies published within the last 10 years regarding treatment for hypertrophic scars...
January 5, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28056476/-advanced-systemic-sclerosis-endovascular-reconstruction-of-the-aortic-bifurcation-for-limb-salvage
#19
Florian Stein, Lars Kamper, Konstantinos Meletiadis, Ulrich Kusenack, Patrick Haage
History and admission findings A 69-year-old patient was initially hospitalized because of a 1.5 cm ulceration at the back of the right foot which had existed for the last year and become increasingly swollen and painful. Medical history revealed PmScl-positive systemic sclerosis presenting with a massive calcinosis cutis, advanced pulmonary fibrosis and peripheral artery disease. Examinations Inflammatory markers were normal. MR-Angiography of the lower extremities revealed a multi-segmental high-grade stenosis of the aortic bifurcation due to extensively calcified plaques...
January 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28056458/selective-m2-macrophage-depletion-leads-to-prolonged-inflammation-in-surgical-wounds
#20
Kerstin Klinkert, Derek Whelan, Anthony J P Clover, Anne-Laure Leblond, Arun H S Kumar, Noel M Caplice
BACKGROUND: A prolonged inflammatory phase is seen in aberrant wound healing and in chronic wounds. Macrophages are central to wound healing. Distinct macrophage subtypes have differing roles both in initial inflammation and in later tissue repair. Broadly, these cells can be divided into M1 and M2 macrophages. M2 macrophage proliferation and differentiation is regulated by colony-stimulating factor 1 (CSF-1) signalling and can be blocked by GW2580, a competitive cFMS kinase inhibitor, thereby allowing for analysis of the effect of M2 blockade on progression of surgical wounds...
January 6, 2017: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
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