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https://www.readbyqxmd.com/read/29356381/biomechanical-analysis-of-decellularized-dermis-and-skin-initial-in-vivo-observations-using-oct-and-vibrational-analysis
#1
Ruchit G Shah, Dale DeVore, Frederick H Silver
Measurement of the mechanical properties of skin in vivo has been complicated by the lack of methods that can accurately measure the viscoelastic properties without assuming values of Poisson's ratio and tissue density. In this paper, we present the results of preliminary studies comparing the mechanical properties of skin and scar tissue measured using a technique involving OCT and vibrational analysis. This technique has been reported to give values of the modulus that correlate with those obtained from tensile measurements made on decellularized dermis [1, 2]...
January 22, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29356204/robotic-surgery-for-submandibular-gland-resection-through-a-trans-hairline-approach-the-first-human-series-and-comparison-with-applicable-approaches
#2
Tsung-Lin Yang
BACKGROUND: Many submandibular gland diseases are treated by surgical intervention. Transcervical surgery results in an obvious cervical scar, whereas the retroauricular approach leaves a scar in the postauricular area. Therefore, robotic submandibular gland resection through a trans-hairline approach is developed to improve postoperative aesthetic outcomes. METHODS: From 2012 to 2017, 24 consecutive patients who met the inclusion criteria and had received submandibular gland resection through the trans-hairline robotic surgery were analyzed...
January 22, 2018: Head & Neck
https://www.readbyqxmd.com/read/29355904/a-multi-centre-open-investigator-initiated-phase-iv-clinical-trial-to-evaluate-the-efficacy-and-safety-of-ingenol-mebutate-gel-0-015-on-the-face-and-scalp-and-0-05-on-the-trunk-and-extremities-in-korean-patients-with-actinic-keratosis-perfect
#3
Y C Kim, J Y Yang, J S Yoon, S J Jo, H H Ahn, K-H Song, D-Y Lee, K-Y Chung, Y-H Won, I-H Kim
BACKGROUND: Ingenol mebutate gel is a novel, field-directed topical treatment for actinic keratosis (AK). Most pivotal studies have targeted Western populations. No clinical study has been conducted to investigate its efficacy and safety in Asian populations. OBJECTIVES: To evaluate the efficacy and safety of ingenol mebutate gel for treating AK of face/scalp and trunk/extremities in a large Asian (Korean) population. METHODS: In this multi-centre, open-label, interventional, parallel group, prospective phase 4 study (PERFECT, NCT02716714), the eligible subjects were allocated into either the face/scalp or the trunk/extremities group, according to their selected treatment area location...
January 20, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29354919/-effects-of-electroacupuncture-at-weizhong-bl-40-on-morphology-and-expression-of-ck-and-il-17-in-rats-with-bupivacaine-induced-multifidus-muscle-injury
#4
Dehui Zou, Yupei Chen, Tong Liu, Zongxiao Lu, Jun Yan, Dongli Chen, Yue Xu, Jiayi Zhang, Yuzhuo Bai, Li Zhang, Zejun Huo
OBJECTIVE: To observe effects of electroacupuncture (EA) at "Weizhong" (BL 40) on morphology and expression of creatine kinase (CK) and interleukin-17 (IL-17) in rats with bupivacaine-induced multifidus muscle injury. METHODS: A total of 32 male SD rats were randomly divided into a control group, a model group, a Weizhong group and a Shenshu group, 8 rats in each one. The rats in the model group, Weizhong group and Shenshu group were treated with intramuscular injection of 0...
September 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29354409/video-assisted-thoracoscopic-surgery-for-drainage-of-dorsal-paravertebral-abscess
#5
Raju Vaishya, Vipul Vijay, Amit K Agarwal
Tuberculosis of the spine is the second most common extrapulmonary presentation of the disease and is associated with significant morbidity. The drainage of the abscess may be needed in patients who fail to respond to medical treatment and present with a significant or deteriorating neurologic status. The dorsal spine gives a unique opportunity for decompression alone as it is supported by the rib cage, decreasing the chances of collapse. Drainage of the abscess in the dorsal spine usually needs an open thoracotomy...
August 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/29354171/the-challenge-of-nonunion-after-osteosynthesis-of-the-clavicle-is-it-a-biomechanical-or-infection-problem
#6
Giuseppe Rollo, Paolo Pichierri, Antonio Marsilio, Marco Filipponi, Michele Bisaccia, Luigi Meccariello
Introduction: The nonunion rate has been reported between 0.1% and 15%. There are also several predisposing factors for the onset of complications: general factors connected with the patient and specific factors related to the fracture site. The purpose of our study is to review the etiology of nonunion of the clavicle in its atrophic form and investigate the outcomes of the revision treatment in a single step. Materials and methods: Retrospective study on 71 patients suffering from nonunions due to the following treatments: conservative in 13 patients; plate fixation in 12; closed reduction and fixation with K-wire in 24; open reduction and fixation with K-wire...
September 2017: Clinical Cases in Mineral and Bone Metabolism
https://www.readbyqxmd.com/read/29353906/caesarean-scar-endometriosis
#7
Nesuma Sedhain, Ganesh Dangal, Aruna Karki, Hema K Pradhan, Ranjana Shrestha, Kabin Bhattachan, Rekha Poudel, Nishma Bajracharya
Endometriosis is a common benign gynecologic disorder defined as the presence of endometrial glands and stroma outside of the normal location. The overall prevalence is 8-15% in women of reproductive age group. Scar endometriosis is a rare disease, and is difficult to diagnose. It is commonly seen following obstetrical and gynecological surgeries. The symptoms are non-specific, typically involving abdominal wall pain at the incision site at the time of menstruation and palpable tender mass in the incision site...
January 1, 2018: Journal of Nepal Health Research Council
https://www.readbyqxmd.com/read/29351444/activated-human-t-lymphocytes-inhibit-tgf%C3%AE-induced-fibroblast-to-myofibroblast-differentiation-via-prostaglandins-d2-and-e2
#8
Shannon H Lacy, Amali P Epa, Stephen J Pollock, Collynn F Woeller, Thomas H Thatcher, Richard P Phipps, Patricia J Sime
In pulmonary fibrosis (PF), fibroblasts and myofibroblasts proliferate and deposit excessive extracellular matrix in the interstitium, impairing normal lung function. As most forms of PF have a poor prognosis and limited treatment options, PF represents an urgent unmet need for novel, effective therapeutics. While the role of immune cells in lung fibrosis is unclear, recent studies suggest that T lymphocyte (T cell) activation may be impaired in PF patients. Further, we have previously shown that activated T cells can produce prostaglandins with anti-scarring potential...
December 20, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/29349667/comparison-of-enalapril-candesartan-and-intralesional-triamcinolone-in-reducing-hypertrophic-scar-development-an-experimental-study
#9
Canser Yilmaz Demir, Muhammet Eren Ersoz, Remzi Erten, Omer Faruk Kocak, Yilmaz Sultanoglu, Yildiray Basbugan
BACKGROUND: The purpose of this study was to compare the effects of oral enalapril, an angiotensin-converting enzyme inhibitor (ACE-I), oral candesartan, an angiotensin receptor blocker (ARB), and intralesional corticosteroid treatments in reducing scar formation. METHODS: Twenty male rabbits were divided into five study groups: A (sham), B (control), C (ACE-I), D (ARB) and E (intralesional corticosteroid). The rabbit ear hypertrophic scar model was used. The hypertrophic scars were photographed and analyzed with the program ImageJ quantitatively to determine the degree of collagen fibers...
January 18, 2018: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29349520/experimental-study-of-5-fluorouracil-encapsulated-ethosomes-combined-with-co2-fractional-laser-to-treat-hypertrophic-scar
#10
Zhen Zhang, Jun Chen, Jun Huang, Yan Wo, Yixin Zhang, Xiangdong Chen
OBJECTIVE: This study is designed to explore permeability of ethosomes encapsulated with 5-florouracil (5-FU) mediated by CO2 fractional laser on hypertrophic scar tissues. Moreover, therapeutic and duration effect of CO2 fractional laser combined with 5-FU encapsulated ethosomes in rabbit ear hypertrophic scar model will be evaluated. METHODS: The permeated amount of 5-FU and retention contents of 5-FU were both determined by high-performance liquid chromatography (HPLC)...
January 18, 2018: Nanoscale Research Letters
https://www.readbyqxmd.com/read/29349055/reconstruction-of-a-traumatic-cleft-earlobe-using-a-combination-of-the-inverted-v-shaped-excision-technique-and-vertical-mattress-suture-method
#11
June Kyu Park, Kyung Sik Kim, Seung Hong Kim, Jun Choi, Jeong Yeol Yang
Traumatic cleft earlobes are a common problem encountered by plastic and reconstructive surgeons. Various techniques have been reported for the repair of traumatic cleft earlobes. Usually, the techniques of split earlobe repair are divided into two categories, namely straight- and broken-line repairs. Straight-line repair is simple and easy, but scar contracture frequently results in notching of the inferior border of the lobule. It can be avoided by the broken-line repair such as Z-plasty, L-plasty, or a V-shaped flap...
December 2017: Archives of Craniofacial Surgery
https://www.readbyqxmd.com/read/29347941/a-five-year-retrospective-study-of-the-epidemiological-characteristics-and-visual-outcomes-of-pediatric-ocular-trauma
#12
Edita Puodžiuvienė, Giedrė Jokūbauskienė, Monika Vieversytė, Kirwan Asselineau
BACKGROUND: Pediatric trauma can lead to serious visual impairment as a result of the trauma itself or secondary to amblyopia. Precise data on epidemiological characteristics and visual outcomes of pediatric ocular injuries are valuable for the prevention of monocular blindness. METHODS: A total of 268 cases of pediatric ocular trauma admitted to the Department of Ophthalmology of the Lithuanian University of Health Sciences Hospital from January 2008 to December 2013 were retrospectively reviewed...
January 18, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29346796/background-factors-and-subjective-voice-symptoms-in-patients-with-acquired-vocal-fold-scarring-and-sulcus-vocalis
#13
Emma Malmström, Stellan Hertegård
OBJECTIVE: Vocal fold scarring (VFS) and sulcus vocalis (SV) often result in severe and chronic voice disorders. This study compares subjective voice complaints as rated with the Voice Handicap Index and etiological factors for patients with VFS and SV. PATIENTS AND METHODS: Data were collected from the medical records at the Department of Otorhinolaryngology, Karolinska University Hospital, for 27 VFS patients and 27 SV patients. Descriptive background factors were compared between the groups and data were compared from the Swedish Voice Handicap Index (Sw-VHI) questionnaires...
January 18, 2018: Folia Phoniatrica et Logopaedica
https://www.readbyqxmd.com/read/29346495/long-term-temporal-changes-in-structure-and-function-of-rat-visual-system-after-blast-exposure
#14
Daniel F Shedd, Nikolaus A Benko, Justin Jones, Brian E Zaugg, Robert L Peiffer, Brittany Coats
Purpose: We identify long-term ocular sequelae subsequent to experimental blast exposure. Methods: Male Long-Evans rats were exposed to 230 kPa side-on primary blast overpressure using a compressed air driven shock tube. Visual system function and structure were assessed for 8 weeks after exposure using optokinetic nystagmus and optical coherence tomography. Vitreous protein expression and histology (TUNEL, H&E) were performed at 1 day and 1, 4, and 8 weeks. IOP was recorded bilaterally during blast in a subset of animals...
January 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29344492/bilateral-hypopyon-uveitis-in-chronic-myeloid-leukemia
#15
Mudit Tyagi, Vishal Govindhari, Rajeev R Pappuru, Vikas Ambiya
Background: A leukemic hypopyon is considered an early sign of central nervous system involvement or systemic relapse. A differential diagnosis of masquerade syndromes should be considered in cases of hypopyon uveitis that are atypical or unresponsive to treatment. We report a case of a 45-year-old man who presented with bilateral hypopyon uveitis and was subsequently diagnosed as having chronic myeloid leukemia. Method: Retrospective case review. Results: A 45-year-old diabetic male presented with diminished vision in both eyes for 10 days...
December 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29344322/acne-scarring-pathogenesis-evaluation-and-treatment-options
#16
REVIEW
Deirdre Connolly, Ha Linh Vu, Kavita Mariwalla, Nazanin Saedi
Acne vulgaris is a ubiquitous problem affecting 80 percent of people ages 11 to 30 years, with many patients experiencing some degree of scarring. This review focuses on atrophic scars, the most common type of acne scar. We briefly address the cellular sequelae that lead to scar formation and the initial evaluation of patients with acne scars. We then discuss an algorithmic approach to the treatment of acne scarring based on the classification of scars into erythematous and atrophic types. Lastly, we discuss the future treatment of acne scars and ongoing clinical trials...
September 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/29341932/synthetic-extracellular-matrix-mimic-hydrogel-improves-efficacy-of-mesenchymal-stromal-cell-therapy-for-ischemic-cardiomyopathy
#17
Maria Chiara Ciuffreda, Giuseppe Malpasso, Cindy Chokoza, Deon Bezuidenhout, Kyle P Goetsch, Manuela Mura, Federica Pisano, Neil H Davies, Massimiliano Gnecchi
BACKGROUND: Mesenchymal stromal cells (MSC) repair infarcted hearts mainly through paracrine mechanisms. Low cell engraftment limits the release of soluble paracrine factors (SF) over time and, consequently, MSC efficacy. We tested whether a synthetic extracellular matrix mimic, a hydrogel containing heparin (H-HG), could ameliorate MSC engraftment and binding/release of SF, thus improving MSC therapy efficacy. METHODS AND RESULTS: In vitro, rat bone-marrow MSC (rBM-MSC) were seeded and grown into H-HG...
January 13, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29341265/cicatricial-alopecia-research-foundation-meeting-may-2016-progress-towards-the-diagnosis-treatment-and-cure-of-primary-cicatricial-alopecias
#18
John P Sundberg, Maria K Hordinsky, Wilma Bergfeld, Yolanda M Lenzy, Amy J McMichael, Angela M Christiano, Tracy McGregor, Kurt S Stenn, Raja K Sivamani, C Herbert Pratt, Lloyd E King
Primary Cicatricial Alopecias (PCAs) are a group of skin diseases in which there is progressive and permanent destruction of hair follicles followed by replacement with fibrous tissue. Unfortunately, by the time patients seek clinical evaluation of their hair loss, the skin is already inflamed and/or scarred, so there is little hope for a return to their normal hair growth pattern. Clinical and basic science investigations are now focusing on three forms of human PCA, lichen planopilaris (LPP), frontal fibrosing alopecia (FFA), and central centrifugal cicatricial alopecia (CCCA)...
January 16, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29341106/the-effect-of-surgery-on-subsequent-pregnancy-outcomes-among-patients-with-cesarean-scar-diverticulum
#19
Xian-Ying Cheng, Li Cheng, Wen-Juan Li, Ling-Hua Qian, Yong-Qin Zhang
OBJECTIVE: To determine whether surgical treatment of cesarean scar diverticulum (CSD) reduced adverse outcomes during the subsequent pregnancy. METHODS: A retrospective observational study was conducted using the medical records of pregnant women with CSD who attended a single hospital in Hangzhou, China, between January 1, 2014, and December 31, 2016. Baseline characteristics and pregnancy outcomes were compared between the surgery group and the no surgery group...
January 17, 2018: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29339002/development-of-a-new-three-directional-distractor-system-for-the-correction-of-maxillary-transverse-and-sagittal-deficiency
#20
Canay Yılmaz Asan, Nükhet Kütük, Gökmen Kurt, Alper Alkan
PURPOSE: Class 3 malocclusions with maxillary deficiency, which are treated surgically and/or ordonotically, are common among adult patients. The aim of this study was to develop a three-directional bone-borne distractor that would allow the transverse expansion and sagittal advancement of the maxilla simultaneously. MATERIALS AND METHODS: Computed tomography images of a patient with maxillary deficiency were transmitted to a software program, and a distractor was designed with different sizes (D1, D2, D3) and manufactured from titanium alloy...
December 18, 2017: Journal of Cranio-maxillo-facial Surgery
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