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https://www.readbyqxmd.com/read/28228454/sex-differences-in-long-term-mortality-after-stroke-in-the-instruct-international-stroke-outcomes-study-a-meta-analysis-of-individual-participant-data
#1
Hoang T Phan, Christopher L Blizzard, Mathew J Reeves, Amanda G Thrift, Dominique Cadilhac, Jonathan Sturm, Emma Heeley, Petr Otahal, Vemmos Konstantinos, Craig Anderson, Priya Parmar, Rita Krishnamurthi, Suzanne Barker-Collo, Valery Feigin, Yannick Bejot, Norberto L Cabral, Antonio Carolei, Simona Sacco, Nicolas Chausson, Stephane Olindo, Peter Rothwell, Carolina Silva, Manuel Correia, Rui Magalhães, Peter Appelros, Janika Kõrv, Riina Vibo, Cesar Minelli, Seana Gall
BACKGROUND: Women are reported to have greater mortality after stroke than men, but the reasons are uncertain. We examined sex differences in mortality at 1 and 5 years after stroke and identified factors contributing to these differences. METHODS AND RESULTS: Individual participant data for incident strokes were obtained from 13 population-based incidence studies conducted in Europe, Australasia, South America, and the Caribbean between 1987 and 2013. Data on sociodemographics, stroke-related factors, prestroke health, and 1- and 5-year survival were obtained...
February 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/28226793/a-comparative-study-of-pseudorandom-sequences-used-in-a-c-vep-based-bci-for-online-wheelchair-control
#2
Jonas Isaksen, Ali Mohebbi, Sadasivan Puthusserypady, Jonas Isaksen, Ali Mohebbi, Sadasivan Puthusserypady, Jonas Isaksen, Sadasivan Puthusserypady, Ali Mohebbi
In this study, a c-VEP based BCI system was developed to run on three distinctive pseudorandom sequences, namely the m-code, the Gold-code, and the Barker-code. The Visual Evoked Potentials (VEPs) were provoked using these codes. In the online session, subjects controlled a LEGO(®) Mindstorms(®) robot around a fixed track. Choosing the optimal code proved a significant increase in accuracy (p<;0.00001) over the average performance. No single code proved significantly more accurate than the others (p=0...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28221079/cue-induced-food-seeking-after-punishment-is-associated-with-increased-fos-expression-in-the-lateral-hypothalamus-and-basolateral-and-medial-amygdala
#3
Erin J Campbell, David J Barker, Helen M Nasser, Konstantin Kaganovsky, Christopher V Dayas, Nathan J Marchant
In humans, relapse to unhealthy eating habits following dieting is a significant impediment to obesity treatment. Food-associated cues are one of the main triggers of relapse to unhealthy eating during self-imposed abstinence. Here we report a behavioral method examining cue-induced relapse to food seeking following punishment-induced suppression of food taking. We trained male rats to lever press for food pellets that were delivered after a 10-s conditional stimulus (CS) (appetitive). Following training, 25% of reinforced lever presses resulted in the presentation of a compound stimulus consisting of a novel CS (aversive) and the appetitive CS followed by a pellet and footshock...
February 20, 2017: Behavioral Neuroscience
https://www.readbyqxmd.com/read/28220657/a-geographic-study-of-west-nile-virus-in-humans-dead-corvids-and-mosquitoes-in-ontario-using-spatial-scan-statistics-with-a-survival-time-application
#4
A L Thomas-Bachli, D L Pearl, O Berke, E J Parmley, I K Barker
Surveillance of West Nile virus (WNv) in Ontario has included passive reporting of human cases and testing of trapped mosquitoes and dead birds found by the public. The dead bird surveillance programme was limited to testing within a public health unit (PHU) until a small number of birds test positive. These dead corvid and mosquito surveillance programmes have not been compared for their ability to provide early warning in geographic areas where human cases occur each year. Spatial scan statistics were applied to time-to-event survival data based on first cases of WNv in found dead corvids, mosquitoes and humans...
February 20, 2017: Zoonoses and Public Health
https://www.readbyqxmd.com/read/28219428/characteristics-and-longitudinal-progression-of-chronic-obstructive-pulmonary-disease-in-gold-b-patients
#5
Philip J Lawrence, Umme Kolsum, Vandana Gupta, Gavin Donaldson, Richa Singh, Bethan Barker, Leena George, Adam Webb, Anthony J Brookes, Christopher Brightling, Jadwiga Wedzicha, Dave Singh
BACKGROUND: The characteristics and natural history of GOLD B COPD patients are not well described. The clinical characteristics and natural history of GOLD B patients over 1 year in a multicentre cohort of COPD patients in the COPDMAP study were assessed. We aimed to identify the subgroup of patients who progressed to GOLD D (unstable GOLD B patients) and identify characteristics associated with progression. METHODS: Three hundred seventy COPD patients were assessed at baseline and 12 months thereafter...
February 20, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28213909/improving-prescribing-practices-a-pharmacist-led-educational-intervention-for-nurse-practitioner-students
#6
Jennifer A Sabatino, Maria C Pruchnicki, Alexa M Sevin, Elizabeth Barker, Christopher G Green, Kyle Porter
BACKGROUND AND PURPOSE: To assess impact of a pharmacist-led educational intervention on family nurse practitioner (FNP) students' prescribing skills, perception of preparedness to prescribe, and perception of pharmacist as collaborator. METHOD: Prospective pre-post assessment of a 14-week educational intervention in an FNP program in the spring semester of 2014. Students participated in an online module of weekly patient cases and prescriptions emphasizing legal requirements, prescription accuracy, and appropriate therapy...
February 18, 2017: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/28213592/the-evidence-of-benefits-of-exercise-training-in-interstitial-lung-disease-a-randomised-controlled-trial
#7
Leona M Dowman, Christine F McDonald, Catherine J Hill, Annemarie L Lee, Kathryn Barker, Claire Boote, Ian Glaspole, Nicole S L Goh, Anne M Southcott, Angela T Burge, Rebecca Gillies, Alicia Martin, Anne E Holland
BACKGROUND: Uncertainty exists regarding the clinical relevance of exercise training across the range of interstitial lung diseases (ILDs). OBJECTIVE: To establish the impact of exercise training in patients with ILDs of differing aetiology and severity. METHODS: 142 participants with ILD (61 idiopathic pulmonary fibrosis (IPF), 22 asbestosis, 23 connective tissue disease-related ILD (CTD-ILD) and 36 with other aetiologies) were randomised to either 8 weeks of supervised exercise training or usual care...
February 17, 2017: Thorax
https://www.readbyqxmd.com/read/28211944/bayesian-response-adaptive-designs-for-basket-trials
#8
Steffen Ventz, William T Barry, Giovanni Parmigiani, Lorenzo Trippa
We develop a general class of response-adaptive Bayesian designs using hierarchical models, and provide open source software to implement them. Our work is motivated by recent master protocols in oncology, where several treatments are investigated simultaneously in one or multiple disease types, and treatment efficacy is expected to vary across biomarker-defined subpopulations. Adaptive trials such as I-SPY-2 (Barker et al., 2009) and BATTLE (Zhou et al., 2008) are special cases within our framework. We discuss the application of our adaptive scheme to two distinct research goals...
February 17, 2017: Biometrics
https://www.readbyqxmd.com/read/28208440/charge-segregation-in-weakly-ionized-microgels
#9
John S Hyatt, Alison M Douglas, Chris Stanley, Changwoo Do, Thomas H Barker, Alberto Fernández-Nieves
We investigate microgels synthesized from N-isopropylacrylamide (NIPAM) copolymerized with a large mol% of acrylic acid, finding that when the acid groups are partially ionized at high temperatures, competition between ion-induced swelling and hydrophobic deswelling of poly(NIPAM) chains results in microphase separation. In cross-linked microgels, this manifests as a dramatic decrease in the ratio between the radius of gyration and the hydrodynamic radius to ∼0.2, indicating that almost all the mass of the microgel is concentrated near the particle center...
January 2017: Physical Review. E
https://www.readbyqxmd.com/read/28207841/barriers-and-enablers-to-the-implementation-of-the-6-pack-falls-prevention-program-a-pre-implementation-study-in-hospitals-participating-in-a-cluster-randomised-controlled-trial
#10
Darshini R Ayton, Anna L Barker, Renata T Morello, Caroline A Brand, Jason Talevski, Fiona S Landgren, Mayer M Melhem, Evelyn Bian, Sandra G Brauer, Keith D Hill, Patricia M Livingston, Mari Botti
Evidence for effective falls prevention interventions in acute wards is limited. One reason for this may be suboptimal program implementation. This study aimed to identify perceived barriers and enablers of the implementation of the 6-PACK falls prevention program to inform the implementation in a randomised controlled trial. Strategies to optimise successful implementation of 6-PACK were also sought. A mixed-methods approach was applied in 24 acute wards from 6 Australian hospitals. Participants were nurses working on participating wards and senior hospital staff including Nurse Unit Managers; senior physicians; Directors of Nursing; and senior personnel involved in quality and safety or falls prevention...
2017: PloS One
https://www.readbyqxmd.com/read/28204086/identification-of-antibody-against-snrpb-small-nuclear-ribonucleoprotein-associated-proteins-b-and-b-as-an-autoantibody-marker-in-crohn-s-disease-using-an-immunoproteomics-approach
#11
Haoyu Wang, Gokhan Demirkan, Xiaofang Bian, Garrick Wallstrom, Kristi Barker, Kailash Karthikeyan, Yanyang Tang, Shabana F Pasha, Jonathan A Leighton, Ji Qiu, Joshua LaBaer
No abstract text is available yet for this article.
February 14, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28199376/acceptability-of-the-6-pack-falls-prevention-program-a-pre-implementation-study-in-hospitals-participating-in-a-cluster-randomized-controlled-trial
#12
Anna L Barker, Renata T Morello, Darshini R Ayton, Keith D Hill, Caroline A Brand, Patricia M Livingston, Mari Botti
There is limited evidence to support the effectiveness of falls prevention interventions in the acute hospital setting. The 6-PACK falls prevention program includes a fall-risk tool; 'falls alert' signs; supervision of patients in the bathroom; ensuring patients' walking aids are within reach; toileting regimes; low-low beds; and bed/chair alarms. This study explored the acceptability of the 6-PACK program from the perspective of nurses and senior staff prior to its implementation in a randomised controlled trial...
2017: PloS One
https://www.readbyqxmd.com/read/28198898/the-synthesis-of-an-edta-like-chelating-peptidomimetic-building-block-suitable-for-solid-phase-peptide-synthesis
#13
Jan Spengler, Michael Barker, Constanze Schelhorn, Jesús García, Maria J Macias, Fernando Albericio
A novo trifunctional EDTA-like peptidomimetic amino acid is described. This unique building block, which is prepared in a straightforward manner from commercialized starting materials, contains three moieties: a hexadentate chelating unit similar to that present in EDTA, and amino and carboxylic groups, which facilitate its introduction into the backbone of peptides using conventional SPPS. As a proof of concept, this building block is introduced into a cyclic peptide inspired from the family of Gratisin analogues...
February 15, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28197672/functional-near-infrared-spectroscopy-fnirs-brain-imaging-of-multi-sensory-integration-during-computerized-dynamic-posturography-in-middle-aged-and-older-adults
#14
Chia-Cheng Lin, Jeffrey W Barker, Patrick J Sparto, Joseph M Furman, Theodore J Huppert
Studies suggest that aging affects the sensory re-weighting process, but the neuroimaging evidence is minimal. Functional Near-Infrared Spectroscopy (fNIRS) is a novel neuroimaging tool that can detect brain activities during dynamic movement condition. In this study, fNIRS was used to investigate the hemodynamic changes in the frontal-lateral, temporal-parietal, and occipital regions of interest (ROIs) during four sensory integration conditions that manipulated visual and somatosensory feedback in 15 middle-aged and 15 older adults...
February 14, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28196717/perinatal-programming-by-inflammation
#15
Sarah J Spencer, Urs Meyer
Since Levine and then Barker's seminal work mid to late last century demonstrating the importance of early life environment, intensive research has revealed the plasticity, vulnerability and resilience of the developing brain to environmental challenges. In particular, early exposure to infectious pathogens and inflammatory stimuli has a lasting impact on brain and behavior. These data establish clear effects on vulnerability to later disease and neuroinflammatory injury, cognitive function and emotionality, and even responses to pain and susceptibility to metabolic disorders...
February 11, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28194751/juvenile-generalized-pustular-psoriasis-is-a-chronic-recalcitrant-disease-an-analysis-of-27-patients-seen-in-a-tertiary-hospital-in-johor-malaysia
#16
Bi-Wen Lau, Dee-Zhen Lim, Francesca Capon, Jonathan N Barker, Siew-Eng Choon
BACKGROUND: Limited information exists regarding juvenile generalized pustular psoriasis (GPP). We aim to determine the clinical profile and outcome of Malaysians with juvenile GPP. METHODS: Review of hospital case notes on patients with juvenile GPP. RESULTS: Twenty-seven patients with juvenile GPP were identified. Female to male ratio was 1.4:1. The median age at onset of GPP was 6.5 years. Ten patients had prior psoriasis with a median pre-pustular duration of 2...
February 14, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28194270/total-synthesis-of-a-key-series-of-vinblastines-modified-at-c4-that-define-the-importance-and-surprising-trends-in-activity
#17
Shouliang Yang, Kuppusamy Sankar, Colin K Skepper, Timothy J Barker, John C Lukesh, Daniel M Brody, Manuela M Brütsch, Dale L Boger
The total synthesis and evaluation of a key systematic series of vinblastines that incorporate the first deep-seated changes to the substituent at C4 are detailed. The synthetic approach features an expanded and redefined scope of a 1,3,4-oxadiazole [4 + 2]/[3 + 2] cycloaddition cascade in which electronically mismatched electron-deficient trisubstituted alkenes and unactivated trisubstituted alkenes were found to productively initiate the cycloaddition cascade with tethered electron-deficient 1,3,4-oxadiazoles...
February 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28193613/apparent-aortic-stiffness-in-children-with-pulmonary-arterial-hypertension-existence-of-vascular-interdependency
#18
Michal Schäfer, D Dunbar Ivy, Steven H Abman, Alex J Barker, Lorna P Browne, Brian Fonseca, Vitaly Kheyfets, Kendall S Hunter, Uyen Truong
BACKGROUND: Left ventricular dysfunction, mediated by ventricular interdependence, has been associated with negative outcomes in children with pulmonary arterial hypertension (PAH). Considering the dilation of the pulmonary arteries as a paramount sign of PAH, we hypothesized that the ascending aorta will present signs of apparent stiffness in children with PAH and that this effect may be because of mechanical interaction with the dilated main pulmonary artery (MPA). METHODS AND RESULTS: Forty-two children with PAH and 26 age- and size-matched controls underwent comprehensive cardiac magnetic resonance evaluation...
February 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28188778/work-limitations-four-years-following-mild-traumatic-brain-injury-a-cohort-study
#19
Alice Theadom, Suzanne Barker-Collo, Kelly Jones, Michael Kahan, Braden Te Ao, Kathryn McPherson, Nicola Starkey, Valery Feigin
OBJECTIVE: To explore employment status, work limitations and productivity loss following mild traumatic brain injury (TBI). STUDY DESIGN: Inception cohort study over four years. SETTING: General community. PARTICIPANTS: 245 Adults (>16 years at the time of injury), who experienced a mild TBI and who were employed prior to their injury. INTERVENTIONS: Not applicable MAIN OUTCOME MEASURES: Details of the injury, demographic information and pre-injury employment status were collected from medical records and self-report...
February 7, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28188448/discrete-barker-frailty-and-warped-mortality-dynamics-at-older-ages
#20
Alberto Palloni, Hiram Beltrán-Sánchez
We develop a discrete variant of a general model for adult mortality influenced by the delayed impact of early conditions on adult health and mortality. The discrete variant of the model builds on an intuitively appealing interpretation of conditions that induce delayed effects and is an extension of the discrete form of the standard frailty model with distinct implications. We show that introducing delayed effects is equivalent to perturbing adult mortality patterns with a particular class of time-/age-varying frailty...
February 10, 2017: Demography
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