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https://www.readbyqxmd.com/read/27922636/dna-methylation-and-substance-use-risk-a-prospective-genome-wide-study-spanning-gestation-to-adolescence
#1
C A M Cecil, E Walton, R G Smith, E Viding, E J McCrory, C L Relton, M Suderman, J-B Pingault, W McArdle, T R Gaunt, J Mill, E D Barker
Epigenetic processes have been implicated in addiction; yet, it remains unclear whether these represent a risk factor and/or a consequence of substance use. Here, we believe we conducted the first genome-wide, longitudinal study to investigate whether DNA methylation patterns in early life prospectively associate with substance use in adolescence. The sample comprised of 244 youth (51% female) from the Avon Longitudinal Study of Parents and Children (ALSPAC), with repeated assessments of DNA methylation (Illumina 450k array; cord blood at birth, whole blood at age 7) and substance use (tobacco, alcohol and cannabis use; age 14-18)...
December 6, 2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27922001/anthropogenic-impacts-on-mosquito-populations-in-north-america-over-the-past-century
#2
Ilia Rochlin, Ary Faraji, Dominick V Ninivaggi, Christopher M Barker, A Marm Kilpatrick
The recent emergence and spread of vector-borne viruses including Zika, chikungunya and dengue has raised concerns that climate change may cause mosquito vectors of these diseases to expand into more temperate regions. However, the long-term impact of other anthropogenic factors on mosquito abundance and distributions is less studied. Here, we show that anthropogenic chemical use (DDT; dichlorodiphenyltrichloroethane) and increasing urbanization were the strongest drivers of changes in mosquito populations over the last eight decades in areas on both coasts of North America...
December 6, 2016: Nature Communications
https://www.readbyqxmd.com/read/27918078/nuclear-ca-2-signalling-in-arbuscular-mycorrhizal-and-actinorhizal-endosymbioses-on-the-trail-of-novel-underground-signals
#3
REVIEW
David G Barker, Mireille Chabaud, Guilia Russo, Andrea Genre
I. II. III. IV. References SUMMARY: Root endosymbioses are beneficial associations formed between terrestrial plants and either bacterial or fungal micro-organisms. A common feature of these intracellular symbioses is the requirement for mutual recognition between the two partners before host-regulated microbial entry. As part of this molecular dialogue, symbiosis-specific microbial factors set in motion a highly conserved plant signal transduction pathway, of which a central component is the activation of sustained nuclear Ca(2+) oscillations in target cells of the host epidermis...
December 5, 2016: New Phytologist
https://www.readbyqxmd.com/read/27916240/spatial-phenotyping-of-the-endocardial-endothelium-as-a-function-of-intracardiac-hemodynamic-shear-stress
#4
Margaret E McCormick, Elisabetta Manduchi, Walter R T Witschey, Robert C Gorman, Joseph H Gorman, Yi-Zhou Jiang, Christian J Stoeckert, Alex J Barker, Samuel Yoon, Michael Markl, Peter F Davies
Despite substantial evidence for the central role of hemodynamic shear stress in the functional integrity of vascular endothelial cells, hemodynamic and molecular regulation of the endocardial endothelium lining the heart chambers remains understudied. We propose that regional differences in intracardiac hemodynamics influence differential endocardial gene expression leading to phenotypic heterogeneity of this cell layer. Measurement of intracardiac hemodynamics was performed using 4-dimensional flow MRI in healthy humans (n=8) and pigs (n=5)...
November 16, 2016: Journal of Biomechanics
https://www.readbyqxmd.com/read/27916113/the-mri-helium-crisis-past-and-future
#5
Mahadevappa Mahesh, Peter B Barker
No abstract text is available yet for this article.
December 2016: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/27913878/piroplasms-in-brown-hyaenas-parahyaena-brunnea-and-spotted-hyaenas-crocuta-crocuta-in-namibia-and-south-africa-are-closely-related-to-babesia-lengau
#6
Richard E J Burroughs, Barend L Penzhorn, Ingrid Wiesel, Nancy Barker, Ilse Vorster, Marinda C Oosthuizen
The objective of our study was identification and molecular characterization of piroplasms and rickettsias occurring in brown (Parahyaena brunnea) and spotted hyaenas (Crocuta crocuta) from various localities in Namibia and South Africa. Whole blood (n = 59) and skin (n = 3) specimens from brown (n = 15) and spotted hyaenas (n = 47) were screened for the presence of Babesia, Theileria, Ehrlichia and Anaplasma species using the reverse line blot (RLB) hybridization technique. PCR products of 52/62 (83...
December 2, 2016: Parasitology Research
https://www.readbyqxmd.com/read/27912729/genomic-insights-from-whole-genome-sequencing-of-four-clonal-outbreak-campylobacter-jejuni-assessed-within-the-global-c-jejuni-population
#7
Clifford G Clark, Chrystal Berry, Matthew Walker, Aaron Petkau, Dillon O R Barker, Cai Guan, Aleisha Reimer, Eduardo N Taboada
BACKGROUND: Whole genome sequencing (WGS) is useful for determining clusters of human cases, investigating outbreaks, and defining the population genetics of bacteria. It also provides information about other aspects of bacterial biology, including classical typing results, virulence, and adaptive strategies of the organism. Cell culture invasion and protein expression patterns of four related multilocus sequence type 21 (ST21) C. jejuni isolates from a significant Canadian water-borne outbreak were previously associated with the presence of a CJIE1 prophage...
December 3, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27911554/thermal-spin-dynamics-of-yttrium-iron-garnet
#8
Joseph Barker, Gerrit E W Bauer
The magnetic insulator yttrium iron garnet can be grown with near perfection and is therefore and ideal conduit for spin currents. It is a complex material with 20 magnetic moments in the unit cell. In spite of being a ferrimagnet, YIG is almost always modeled as a simple ferromagnet with a single spin wave mode. We use the method of atomistic spin dynamics to study the temperature evolution of the full spin wave spectrum, in quantitative agreement with neutron scattering experiments. The antiferromagnetic or optical mode is found to suppress the spin Seebeck effect at room temperature and beyond due to thermally pumped spin currents with opposite polarization to the ferromagnetic mode...
November 18, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27910447/design-of-the-polar-neutron-imaging-aperture-for-use-at-the-national-ignition-facility
#9
V E Fatherley, D A Barker, D N Fittinghoff, R L Hibbard, J I Martinez, F E Merrill, J A Oertel, D W Schmidt, P L Volegov, C H Wilde
The installation of a neutron imaging diagnostic with a polar view at the National Ignition Facility (NIF) required design of a new aperture, an extended pinhole array (PHA). This PHA is different from the pinhole array for the existing equatorial system due to significant changes in the alignment and recording systems. The complex set of component requirements, as well as significant space constraints in its intended location, makes the design of this aperture challenging. In addition, lessons learned from development of prior apertures mandate careful aperture metrology prior to first use...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910188/comparing-rewarding-and-reinforcing-properties-between-bath-salt-3-4-methylenedioxypyrovalerone-mdpv-and-cocaine-using-ultrasonic-vocalizations-in-rats
#10
Steven J Simmons, Ryan A Gregg, Fionya H Tran, Lili Mo, Eva von Weltin, David J Barker, Taylor A Gentile, Lucas R Watterson, Scott M Rawls, John W Muschamp
Abuse of synthetic psychostimulants like synthetic cathinones has risen in recent years. 3,4-Methylenedioxypyrovalerone (MDPV) is one such synthetic cathinone that demonstrates a mechanism of action similar to cocaine. Compared to cocaine, MDPV is more potent at blocking dopamine and norepinephrine reuptake and is readily self-administered by rodents. The present study compared the rewarding and reinforcing properties of MDPV and cocaine using systemic injection dose-response and self-administration models...
December 1, 2016: Addiction Biology
https://www.readbyqxmd.com/read/27908679/skin-surface-brachytherapy-a-survey-of-contemporary-practice-patterns
#11
Anna O Likhacheva, Phillip M Devlin, Shervin M Shirvani, Christopher A Barker, Phillip Beron, Ajay Bhatnagar, Stephen W Doggett, Lawrence Hochman, Charles Hsu, Michael Kasper, Martin Keisch, Subhakar Mutyala, Bradley Prestidge, Silvia Rodriguez Villalba, Vershalee Shukla, Srinath Sundararaman, Mitchell Kamrava
PURPOSE: The aim of this study was to define current patterns of care among radiation oncologists who use skin surface brachytherapy for the treatment of cutaneous squamous cell carcinoma (cSCC) and basal cell carcinoma (BCC) in academic and community settings. METHODS AND MATERIALS: A 30-question electronic survey was administered to clinician members of the American Brachytherapy Society. The respondents were asked to provide details regarding their clinical practice and their approach to skin surface brachytherapy...
November 28, 2016: Brachytherapy
https://www.readbyqxmd.com/read/27908057/a-corpus-of-noise-induced-word-misperceptions-for-english
#12
Ricard Marxer, Jon Barker, Martin Cooke, Maria Luisa Garcia Lecumberri
Words spoken against a noise background often form an ambiguous percept. However, in certain conditions, a listener will mishear a noisy word but report hearing the same incorrect word as reported by other listeners. These consistent hearing errors are valuable as tests of detailed models of speech perception. This paper describes the collection of a corpus of consistent speech misperceptions for English. The mishearings were elicited using a large scale listening study involving 212 participants and over 300 000 token presentations...
November 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27905956/summarizing-health-related-quality-of-life-hrqol-development-and-testing-of-a-one-factor-model
#13
Shaoman Yin, Rashid Njai, Lawrence Barker, Paul Z Siegel, Youlian Liao
BACKGROUND: Health-related quality of life (HRQOL) is a multi-dimensional concept commonly used to examine the impact of health status on quality of life. HRQOL is often measured by four core questions that asked about general health status and number of unhealthy days in the Behavioral Risk Factor Surveillance System (BRFSS). Use of these measures individually, however, may not provide a cohesive picture of overall HRQOL. To address this concern, this study developed and tested a method for combining these four measures into a summary score...
July 11, 2016: Population Health Metrics
https://www.readbyqxmd.com/read/27903127/introduction-craniopharyngioma-current-and-emerging-treatment-modalities
#14
Fred G Barker, Rudolf Fahlbusch, Theodore H Schwartz, Jeffrey H Wisoff
No abstract text is available yet for this article.
December 2016: Neurosurgical Focus
https://www.readbyqxmd.com/read/27903124/diagnosis-and-management-of-craniopharyngiomas-in-the-era-of-genomics-and-targeted-therapy
#15
Juan Carlos Martinez-Gutierrez, Megan R D'Andrea, Daniel P Cahill, Sandro Santagata, Fred G Barker, Priscilla K Brastianos
Craniopharyngiomas are rare intracranial neoplasms that pose clinical challenges due to their location adjacent to vital structures. The authors have previously shown high mutation rates of BRAF V600E in papillary craniopharyngioma and of CTNNB1 in adamantinomatous craniopharyngioma. These activating driver mutations are potential therapeutic targets, and the authors have recently reported a significant response to BRAF/MEK inhibition in a patient with multiply recurrent PCP. As these targetable mutations warrant prospective research, the authors will be conducting a national National Cancer Institute-sponsored multicenter clinical trial to investigate BRAF/MEK inhibition in the treatment of craniopharyngioma...
December 2016: Neurosurgical Focus
https://www.readbyqxmd.com/read/27900190/prospective-12-month-functional-and-vocational-outcomes-of-hip-arthroscopy-for-femoroacetabular-impingement-as-part-of-an-evidence-based-hip-pain-rehabilitation-pathway-in-an-active-military-population
#16
A N Bennett, J Nixon, A Roberts, R Barker-Davies, R Villar, J M Houghton
BACKGROUND: Femoroacetabular impingement (FAI) is common with an estimated prevalence of 10-15% among young active individuals. The natural history of the disorder is progression to early osteoarthritis. Hip arthroscopy is recommended if conservative treatments fail; however, outcomes are unclear, particularly in highly active populations. AIM: To evaluate the functional and vocational outcome of hip arthroscopy, as part of an evidence-based rehabilitation hip pain pathway, for the treatment of FAI in an active military population...
2016: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/27898072/elevated-brain-lactate-in-schizophrenia-a-7%C3%A2-t-magnetic-resonance-spectroscopy-study
#17
L M Rowland, S Pradhan, S Korenic, S A Wijtenburg, L E Hong, R A Edden, P B Barker
Various lines of evidence suggest that brain bioenergetics and mitochondrial function may be altered in schizophrenia. On the basis of prior phosphorus-31 ((31)P)-magnetic resonance spectroscopy (MRS), post-mortem and preclinical studies, this study was designed to test the hypothesis that abnormal glycolysis leads to elevated lactate concentrations in subjects with schizophrenia. The high sensitivity of 7 Tesla proton ((1)H)-MRS was used to measure brain lactate levels in vivo. Twenty-nine controls and 27 participants with schizophrenia completed the study...
November 29, 2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27897740/evidence-based-practice-for-nurses-and-healthcare-professionals-third-edition-barker-janet-linsley-paul-kane-ros-evidence-based-practice-for-nurses-and-healthcare-professionals-third-edition-240pp-%C3%A2-22-99-sage-9781473925038-1473925037-formula-see-text
#18
(no author information available yet)
This book provides a complete primer on the subject of evidence-based practice in health care. As an introductory single textbook, it is especially useful for nurses undertaking academic study, or who are new to the subject.
November 16, 2016: Nursing Standard
https://www.readbyqxmd.com/read/27897188/community-participation-for-individuals-with-spinal-cord-injury-living-in-queensland-australia
#19
J J Carr, M B Kendall, D I Amsters, K J Pershouse, P Kuipers, P Buettner, R N Barker
STUDY DESIGN: Sequential mixed method design. OBJECTIVES: Determine factors associated with community participation for individuals with spinal cord injury (SCI). SETTING: Queensland, Australia. METHODS: Phase I consisted of a quantitative telephone survey of 270 people who had sustained a SCI within the past 50 years. To verify and interpret survey findings, Phase II involved a qualitative investigation. One focus group, one dyadic and one in-depth interview were conducted with a separate sample of eight people who had sustained a SCI within the past 50 years...
November 29, 2016: Spinal Cord
https://www.readbyqxmd.com/read/27894631/elderly-woman-with-altered-mental-status-and-hypoxia
#20
Rebecca A Martin, David Wharton, Chad Barker, Claudia D Haivas, Berneet Kaur, Jessica Whittle
No abstract text is available yet for this article.
December 2016: Annals of Emergency Medicine
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