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https://www.readbyqxmd.com/read/28720809/microbial-turnover-times-in-the-deep-seabed-studied-by-amino-acid-racemization-modelling
#1
Stefan Braun, Snehit S Mhatre, Marion Jaussi, Hans Røy, Kasper U Kjeldsen, Christof Pearce, Marit-Solveig Seidenkrantz, Bo Barker Jørgensen, Bente Aa Lomstein
The study of active microbial populations in deep, energy-limited marine sediments has extended our knowledge of the limits of life on Earth. Typically, microbial activity in the deep biosphere is calculated by transport-reaction modelling of pore water solutes or from experimental measurements involving radiotracers. Here we modelled microbial activity from the degree of D:L-aspartic acid racemization in microbial necromass (remains of dead microbial biomass) in sediments up to ten million years old. This recently developed approach (D:L-amino acid modelling) does not require incubation experiments and is highly sensitive in stable, low-activity environments...
July 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28718799/zebrafish-as-a-model-organism-for-the-development-of-drugs-for-skin-cancer
#2
REVIEW
Fatemeh Bootorabi, Hamed Manouchehri, Reza Changizi, Harlan Barker, Elisabetta Palazzo, Annalisa Saltari, Mataleena Parikka, Carlo Pincelli, Ashok Aspatwar
Skin cancer, which includes melanoma and squamous cell carcinoma, represents the most common type of cutaneous malignancy worldwide, and its incidence is expected to rise in the near future. This condition derives from acquired genetic dysregulation of signaling pathways involved in the proliferation and apoptosis of skin cells. The development of animal models has allowed a better understanding of these pathomechanisms, with the possibility of carrying out toxicological screening and drug development. In particular, the zebrafish (Danio rerio) has been established as one of the most important model organisms for cancer research...
July 18, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28716796/clinical-and-cost-effectiveness-of-progressive-exercise-compared-with-best-practice-advice-with-or-without-corticosteroid-injection-for-the-treatment-of-rotator-cuff-disorders-protocol-for-a-2x2-factorial-randomised-controlled-trial-the-grasp-trial
#3
Sally Hopewell, David J Keene, Michael Maia Schlüssel, Melina Dritsaki, Susan Dutton, Andrew Carr, William Hamilton, Zara Hansen, Anju Jaggi, Chris Littlewood, Hessam Soutakbar, Peter Heine, Lucy Cureton, Karen Barker, Sarah E Lamb
INTRODUCTION: Shoulder pain is very common, with around 70% of cases due to disorders of the rotator cuff. Despite widespread provision of physiotherapy, there is uncertainty about which type of exercise and delivery mechanisms are associated with best outcomes. There is also uncertainty around the long-term benefits and harms of corticosteroid injection therapy, which is often used in addition to physiotherapy. The Getting it Right: Addressing Shoulder Pain trial will assess the clinical and cost-effectiveness of individually tailored, progressive exercise compared with best practice advice, with or without corticosteroid injection, in adults with a rotator cuff disorder...
July 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/28716717/big-gaba-edited-mr-spectroscopy-at-24-research-sites
#4
Mark Mikkelsen, Peter B Barker, Pallab K Bhattacharyya, Maiken K Brix, Pieter F Buur, Kim M Cecil, Kimberly L Chan, David Y-T Chen, Alexander R Craven, Koen Cuypers, Michael Dacko, Niall W Duncan, Ulrike Dydak, David A Edmondson, Gabriele Ende, Lars Ersland, Fei Gao, Ian Greenhouse, Ashley D Harris, Naying He, Stefanie Heba, Nigel Hoggard, Tun-Wei Hsu, Jacobus F A Jansen, Alayar Kangarlu, Thomas Lange, R Marc Lebel, Yan Li, Chien-Yuan E Lin, Jy-Kang Liou, Jiing-Feng Lirng, Feng Liu, Ruoyun Ma, Celine Maes, Marta Moreno-Ortega, Scott O Murray, Sean Noah, Ralph Noeske, Michael D Noseworthy, Georg Oeltzschner, James J Prisciandaro, Nicolaas A J Puts, Timothy P L Roberts, Markus Sack, Napapon Sailasuta, Muhammad G Saleh, Michael-Paul Schallmo, Nicholas Simard, Stephan P Swinnen, Martin Tegenthoff, Peter Truong, Guangbin Wang, Iain D Wilkinson, Hans-Jörg Wittsack, Hongmin Xu, Fuhua Yan, Chencheng Zhang, Vadim Zipunnikov, Helge J Zöllner, Richard A E Edden
Magnetic resonance spectroscopy (MRS) is the only biomedical imaging method that can noninvasively detect endogenous signals from the neurotransmitter γ-aminobutyric acid (GABA) in the human brain. Its increasing popularity has been aided by improvements in scanner hardware and acquisition methodology, as well as by broader access to pulse sequences that can selectively detect GABA, in particular J-difference spectral editing sequences. Nevertheless, implementations of GABA-edited MRS remain diverse across research sites, making comparisons between studies challenging...
July 14, 2017: NeuroImage
https://www.readbyqxmd.com/read/28715700/a-simultaneous-multi-slice-selective-j-resolved-experiment-for-fully-resolved-scalar-coupling-information
#5
Qing Zeng, Liangjie Lin, Jinyong Chen, Yanqin Lin, Peter B Barker, Zhong Chen
Proton-proton scalar coupling plays an important role in molecular structure elucidation. Many methods have been proposed for revealing scalar coupling networks involving chosen protons. However, determining all JHH values within a fully coupled network remains as a tedious process. Here, we propose a method termed as simultaneous multi-slice selective J-resolved spectroscopy (SMS-SEJRES) for simultaneously measuring JHH values out of all coupling networks in a sample within one experiment. In this work, gradient-encoded selective refocusing, PSYCHE decoupling and echo planar spectroscopic imaging (EPSI) detection module are adopted, resulting in different selective J-edited spectra extracted from different spatial positions...
July 10, 2017: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/28715198/structural-variations-in-hybrid-all-nanoparticle-gibbsite-nanoplatelet-cellulose-nanocrystal-multilayered-films
#6
Clélia Martin, Robert David Barker, Erik B Watkins, Frederic Dubreuil, Emily D Cranston, Laurent Heux, Bruno Jean
Cellulose nanocrystals (CNCs) are promising bio-sourced building blocks for the production of high performance materials. In the last ten years, CNCs have been used in conjunction with polymers for the design of multilayered thin films via the layer-by-layer assembly technique. Herein, polymer chains have been replaced with positively charged inorganic gibbsite nanoplatelets (GN) to form hybrid "nanoparticle-only" composite films. A combination of atomic force microscopy and neutron reflectivity experiments was exploited to investigate the growth and structure of the films...
July 17, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28713440/investigating-the-physical-stability-of-repackaged-medicines-stored-into-commercially-available-multicompartment-compliance-aids-mcas
#7
Bahijja Tolulope Raimi-Abraham, Alba Garcia Del Valle, Carlota Varon Galcera, Susan Anne Barker, Mine Orlu
BACKGROUND: Compliance aids are devices which have been developed and are currently used to assist individuals in their medicines management. The use of compliance aids involves the transfer of medicines from the manufacturers' original packaging and repackaged into an multicompartment compliance aid (MCA). MCAs do not guarantee the same level of protection compared to manufacturer's original packaging. OBJECTIVE: The aim of this study was to investigate the stability profile of atenolol, aspirin and lansoprazole dosage forms repackaged together in two different commercially available MCAs...
June 2017: Journal of Pharmaceutical Health Services Research
https://www.readbyqxmd.com/read/28713351/a-genome-wide-association-study-to-identify-diagnostic-markers-for-human-pathogenic-campylobacter-jejuni-strains
#8
Cody J Buchanan, Andrew L Webb, Steven K Mutschall, Peter Kruczkiewicz, Dillon O R Barker, Benjamin M Hetman, Victor P J Gannon, D Wade Abbott, James E Thomas, G Douglas Inglis, Eduardo N Taboada
Campylobacter jejuni is a leading human enteric pathogen worldwide and despite an improved understanding of its biology, ecology, and epidemiology, limited tools exist for identifying strains that are likely to cause disease. In the current study, we used subtyping data in a database representing over 24,000 isolates collected through various surveillance projects in Canada to identify 166 representative genomes from prevalent C. jejuni subtypes for whole genome sequencing. The sequence data was used in a genome-wide association study (GWAS) aimed at identifying accessory gene markers associated with clinically related C...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28711727/a-chemotherapy-only-regimen-of-busulfan-melphalan-and-fludarabine-and-rabbit-atg-followed-by-allogeneic-t-cell-depleted-hematopoietic-stem-cell-transplants-for-the-treatment-of-myeloid-malignancies
#9
Barbara Spitzer, Ann A Jakubowski, Esperanza B Papadopoulos, Kirsten Fuller, Patrick D Hilden, James W Young, Juliet Barker, Guenther Koehne, Miguel-Angel Perales, Katharine C Hsu, Marcel R M van den Brink, Nancy A Kernan, Susan E Prockop, Andromachi Scaradavou, Hugo Castro-Malaspina, Richard J O'Reilly, Farid Boulad
We sought to develop a myeloablative chemotherapeutic regimen to secure consistent engraftment of T-cell depleted (TCD) hematopoietic stem cell transplants (HSCT) without the need for total body irradiation, thereby reducing toxicity, while maintaining low rates of GvHD and without increasing relapse. We investigated the myeloablative combination of busulfan and melphalan, with the immunosuppressive agents fludarabine and rabbit anti-thymocyte gloubin (r-ATG) as cytoreduction prior to a T-cell depleted HSCT...
July 12, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28710090/the-clinical-and-economic-effect-of-vascular-access-selection-in-patients-initiating-hemodialysis-with-a-catheter
#10
Alian Al-Balas, Timmy Lee, Carlton J Young, Jeffrey A Kepes, Jill Barker-Finkel, Michael Allon
Patients in the United States frequently initiate hemodialysis with a central venous catheter (CVC) and subsequently undergo placement of a new arteriovenous fistula (AVF) or arteriovenous graft (AVG). Little is known about the clinical and economic effects of initial vascular access choice. We identified 479 patients starting hemodialysis with a CVC at a large medical center (during 2004-2012) who subsequently had an AVF (n=295) or AVG (n=105) placed or no arteriovenous access (CVC group, n=71). Compared with patients receiving an AVG, those receiving an AVF had more frequent surgical access procedures per year (1...
July 14, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28706199/defective-sphingosine-1-phosphate-metabolism-is-a-druggable-target-in-huntington-s-disease
#11
Alba Di Pardo, Enrico Amico, Abdul Basit, Andrea Armirotti, Piyush Joshi, Diana M Neely, Romina Vuono, Salvatore Castaldo, Anna F Digilio, Francesco Scalabrì, Giuseppe Pepe, Francesca Elifani, Michele Madonna, Se Kyoo Jeong, Bu-Mahn Park, Maurizio D'Esposito, Aaron B Bowman, Roger A Barker, Vittorio Maglione
Huntington's disease is characterized by a complex and heterogeneous pathogenic profile. Studies have shown that disturbance in lipid homeostasis may represent a critical determinant in the progression of several neurodegenerative disorders. The recognition of perturbed lipid metabolism is only recently becoming evident in HD. In order to provide more insight into the nature of such a perturbation and into the effect its modulation may have in HD pathology, we investigated the metabolism of Sphingosine-1-phosphate (S1P), one of the most important bioactive lipids, in both animal models and patient samples...
July 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28704644/amide-proton-transfer-weighted-magnetic-resonance-image-guided-stereotactic-biopsy-in-patients-with-newly-diagnosed-gliomas
#12
Shanshan Jiang, Charles G Eberhart, Yi Zhang, Hye-Young Heo, Zhibo Wen, Lindsay Blair, Huamin Qin, Michael Lim, Alfredo Quinones-Hinojosa, Jon D Weingart, Peter B Barker, Martin G Pomper, John Laterra, Peter C M van Zijl, Jaishri O Blakeley, Jinyuan Zhou
PURPOSE: Pathological assessment using World Health Organization (WHO) criteria is the gold standard for diagnosis of gliomas. However, the accuracy of diagnosis is limited by tissue sampling, particularly for infiltrating, heterogeneous tumours. We assessed the accuracy of amide proton transfer-weighted (APTw) magnetic resonance imaging (MRI)-guided tissue sampling to identify regions of high-grade glioma via radiographic-histopathologic correlation in patients with newly suspected glioma...
July 10, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28702509/loss-of-function-variants-of-scn8a-in-intellectual-disability-without-seizures
#13
Jacy L Wagnon, Bryan S Barker, Matteo Ottolini, Young Park, Alicia Volkheimer, Purnima Valdez, Marielle E M Swinkels, Manoj K Patel, Miriam H Meisler
OBJECTIVE: To determine the functional effect of SCN8A missense mutations in 2 children with intellectual disability and developmental delay but no seizures. METHODS: Genomic DNA was analyzed by next-generation sequencing. SCN8A variants were introduced into the Nav1.6 complementary DNA by site-directed mutagenesis. Channel activity was measured electrophysiologically in transfected ND7/23 cells. The stability of the mutant channels was assessed by Western blot...
August 2017: Neurology. Genetics
https://www.readbyqxmd.com/read/28701772/genetic-targeting-and-anatomical-registration-of-neuronal-populations-in-the-zebrafish-brain-with-a-new-set-of-bac-transgenic-tools
#14
Dominique Förster, Irene Arnold-Ammer, Eva Laurell, Alison J Barker, António M Fernandes, Karin Finger-Baier, Alessandro Filosa, Thomas O Helmbrecht, Yvonne Kölsch, Enrico Kühn, Estuardo Robles, Krasimir Slanchev, Tod R Thiele, Herwig Baier, Fumi Kubo
Genetic access to small, reproducible sets of neurons is key to an understanding of the functional wiring of the brain. Here we report the generation of a new Gal4- and Cre-driver resource for zebrafish neurobiology. Candidate genes, including cell type-specific transcription factors, neurotransmitter-synthesizing enzymes and neuropeptides, were selected according to their expression patterns in small and unique subsets of neurons from diverse brain regions. BAC recombineering, followed by Tol2 transgenesis, was used to generate driver lines that label neuronal populations in patterns that, to a large but variable extent, recapitulate the endogenous gene expression...
July 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28699772/incorporating-cardiopulmonary-resuscitation-training-into-a-cardiac-rehabilitation-programme-a-feasibility-study
#15
Susie Cartledge, Judith Finn, Janet E Bray, Rosalind Case, Lauren Barker, Diane Missen, James Shaw, Dion Stub
BACKGROUND: Patients with a cardiac history are at future risk of cardiac events, including out-of-hospital cardiac arrest. Targeting cardiopulmonary resuscitation (CPR) training to family members of cardiac patients has long been advocated, but is an area in need of contemporary research evidence. An environment yet to be investigated for targeted training is cardiac rehabilitation. AIM: To evaluate the feasibility of providing CPR training in a cardiac rehabilitation programme among patients, their family members and staff...
July 1, 2017: European Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/28699736/detection-of-an-integrin-binding-mechanoswitch-within-fibronectin-during-tissue-formation-and-fibrosis
#16
Lizhi Cao, John Nicosia, Jacqueline Larouche, Yuanyuan Zhang, Haylee Bachman, Ashley C Brown, Lars Holmgren, Thomas H Barker
Fibronectin (Fn) is an extracellular matrix protein that orchestrates complex cell adhesion and signaling through cell surface integrin receptors during tissue development, remodeling, and disease, such as fibrosis. Fn is sensitive to mechanical forces in its tandem type III repeats, resulting in extensive molecular enlongation. As such, it has long been hypothesized that cell- and tissue-derived forces may activate an "integrin switch" within the critical integrin-binding ninth and 10th type III repeats-conferring differential integrin-binding specificity, leading to differential cell responses...
July 12, 2017: ACS Nano
https://www.readbyqxmd.com/read/28696383/alfalfa-responses-to-gypsum-application-measured-using-undisturbed-soil-columns
#17
Rebecca Tirado-Corbalá, Brian K Slater, Warren A Dick, Dave Barker
Gypsum is an excellent source of Ca and S, both of which are required for crop growth. Large amounts of by-product gypsum [Flue gas desulfurization gypsum-(FGDG)] are produced from coal combustion in the United States, but only 4% is used for agricultural purposes. The objective of this study was to evaluate the effects of (1) untreated, (2) short-term (4-year annual applications of gypsum totaling 6720 kg ha(-1)), and (3) long-term (12-year annual applications of gypsum totaling 20,200 kg ha(-1)) on alfalfa (Medicago sativa L...
July 11, 2017: Plants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28695949/synthesis-and-biological-evaluation-of-the-ascidian-blood-pigment-halocyamine-a
#18
Hugo K H Fong, Jean Michel Brunel, Arlette Longeon, Marie-Lise Bourguet-Kondracki, David Barker, Brent R Copp
Synthesis of the antimicrobial marine natural product halocyamine A has been achieved utilizing a combination of Sonogashira coupling, ruthenium complex/ytterbium triflate catalyzed hydroamidation and solid-phase peptide synthesis (SPPS) chemistry. The synthetic natural product exhibited only modest levels of antibacterial activities but significant antioxidant activity.
July 11, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28694532/membrane-association-landscape-of-myelin-basic-protein-portrays-formation-of-the-myelin-major-dense-line
#19
Arne Raasakka, Salla Ruskamo, Julia Kowal, Robert Barker, Anne Baumann, Anne Martel, Jussi Tuusa, Matti Myllykoski, Jochen Bürck, Anne S Ulrich, Henning Stahlberg, Petri Kursula
Compact myelin comprises most of the dry weight of myelin, and its insulative nature is the basis for saltatory conduction of nerve impulses. The major dense line (MDL) is a 3-nm compartment between two cytoplasmic leaflets of stacked myelin membranes, mostly occupied by a myelin basic protein (MBP) phase. MBP is an abundant myelin protein involved in demyelinating diseases, such as multiple sclerosis. The association of MBP with lipid membranes has been studied for decades, but the MBP-driven formation of the MDL remains elusive at the biomolecular level...
July 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28690923/voxel-placement-precision-for-gaba-edited-magnetic-resonance-spectroscopy
#20
Xue Bai, Ashley D Harris, Tao Gong, Nicolaas A J Puts, Guangbin Wang, Michael Schär, Peter B Barker, Richard A E Edden
The purpose of the present study was to assess the reproducibility of voxel placement for GABA-edited MRS. GABA-edited MRS data were acquired in 13 healthy volunteers from (3 cm)(3) voxel; and within the same session a second acquisition was independently prescribed. A three-dimensional voxel mask image was reconstructed in T1-image-space using the SVMask tool (in house software). Reproducibility of voxel placement was assessed using the Dice overlap coefficient, both within-subject and between-subject following co-registration of T1 images and transformation of voxel mask images to standard space...
March 2017: Open J Radiol
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