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https://www.readbyqxmd.com/read/29162179/variation-in-dna-methylation-of-the-oxytocin-receptor-gene-predicts-children-s-resilience-to-prenatal-stress
#1
Izabela Milaniak, Charlotte A M Cecil, Edward D Barker, Caroline L Relton, Tom R Gaunt, Wendy McArdle, Sara R Jaffee
Emerging research in epigenetics has shown that there is variability in how environmental exposures "get under the skin" through mechanisms like DNA methylation to influence gene expression that may lead to differential adaptations to stress. This is the first study to examine prospectively the relationship between DNA methylation at birth and resilience to prenatal environmental stressors in several domains (conduct, hyperactivity, emotional problems, and global symptomatology) in middle childhood. We focused on DNA methylation in the vicinity of the oxytocin receptor (OXTR) gene as it has been previously associated with impairments in social-cognitive processes that may underlie a wide range of childhood psychopathology...
December 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/29156933/-prevention-of-obesity-from-perinatal-stage
#2
Rosa Mª Martínez García, Ana Isabel Jiménez Ortega, Heldry González Torres, Rosa María Ortega
Obesity is one of the major health problems and a determining factor in the prevalence of diseases such as metabolic syndrome, asthma, sleep apnea, infertility and various types of cancer. Its origin is multifactorial, involving genetic, socioeconomic and environmental factors. These last ones contribute mostly to explain the current epidemic growth of this disease. The sedentary lifestyle, inadequate diet, lack of sleep, alterations in intestinal microbiota and stress are factors related to its development...
October 15, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29152558/erratum-author-correction-using-a-smartphone-based-self-management-platform-to-support-medication-adherence-and-clinical-consultation-in-parkinson-s-disease
#3
Rashmi Lakshminarayana, Duolao Wang, David Burn, K Ray Chaudhuri, Clare Galtrey, Natalie Valle Guzman, Bruce Hellman, Ben James, Suvankar Pal, Jon Stamford, Malcolm Steiger, R W Stott, James Teo, Roger A Barker, Emma Wang, Bastiaan R Bloem, Martijn van der Eijk, Lynn Rochester, Adrian Williams
[This corrects the article DOI: 10.1038/s41531-016-0003-z.].
2017: NPJ Parkinson's Disease
https://www.readbyqxmd.com/read/29149897/enablers-and-barriers-to-secondary-prophylaxis-for-rheumatic-fever-among-m%C3%A4-ori-aged-14-21-in-new-zealand-a-framework-method-study
#4
Hilary Barker, John G Oetzel, Nina Scott, Michelle Morley, Polly E Atatoa Carr, Keri Bolton Oetzel
BACKGROUND: Acute rheumatic fever (ARF) rates have declined to near zero in nearly all developed countries. However, in New Zealand rates have not declined since the 1980s. Further, ARF diagnoses in New Zealand are inequitably distributed--occurring almost exclusively in Māori (the indigenous population) and Pacific children--with very low rates in the majority New Zealand European population. With ARF diagnosis, secondary prophylaxis is key to prevent recurrence. The purpose of this study was to identify the perceived enablers and barriers to secondary recurrence prophylaxis following ARF for Māori patients aged 14-21...
November 17, 2017: International Journal for Equity in Health
https://www.readbyqxmd.com/read/29148160/chronic-parenting-stress-and-mood-reactivity-the-role-of-sleep-quality
#5
Chelsea da Estrela, Erin T Barker, Sarah Lantagne, Jean-Philippe Gouin
Sleep is a basic biological process supporting emotion regulation. The emotion regulation function of sleep may be particularly important in the context of chronic stress. To better understand how chronic stress and sleep interact to predict mood, 66 parents of children with autism completed daily diaries assessing parenting stress, negative mood, and sleep quality for 6 consecutive days. Hierarchical linear modelling revealed that daily negative mood was predicted by between-person differences in parenting stress and between-person differences in sleep efficiency...
November 17, 2017: Stress and Health: Journal of the International Society for the Investigation of Stress
https://www.readbyqxmd.com/read/29145590/who-uses-foodbanks-and-why-exploring-the-impact-of-financial-strain-and-adverse-life-events-on-food-insecurity
#6
E Prayogo, A Chater, S Chapman, M Barker, N Rahmawati, T Waterfall, G Grimble
Background: Rising use of foodbanks highlights food insecurity in the UK. Adverse life events (e.g. unemployment, benefit delays or sanctions) and financial strains are thought to be the drivers of foodbank use. This research aimed to explore who uses foodbanks, and factors associated with increased food insecurity. Methods: We surveyed those seeking help from front line crisis providers from foodbanks (N = 270) and a comparison group from Advice Centres (ACs) (N = 245) in relation to demographics, adverse life events, financial strain and household food security...
November 14, 2017: Journal of Public Health
https://www.readbyqxmd.com/read/29145207/determinants-prevalence-and-trajectory-of-long-term-post-stroke-cognitive-impairment-results-from-a-4-year-follow-up-of-the-auckland-stroke-regional-outcomes-study-iv-study
#7
Susan Mahon, Priya Parmar, Suzanne Barker-Collo, Rita Krishnamurthi, Kelly Jones, Alice Theadom, Valery Feigin
BACKGROUND: The long-term (>12 months) prevalence, predictors, and trajectory of post-stroke cognitive deficits are not well established, especially at a community level. This study investigated the longitudinal course and prevalence of cognitive impairment in an incidence cohort, identifying factors associated with declining cognition. METHODS: Two hundred fifty-seven participants (mean age = 67.93 ± 13.59) of first-ever stroke survivors, completed cognitive assessments within 2 weeks post stroke, and/or 1, 6, 12, and 48-month...
November 16, 2017: Neuroepidemiology
https://www.readbyqxmd.com/read/29142047/multi-center-evaluation-of-the-vitek-ms-v3-0-system-for-the-identification-of-filamentous-fungi
#8
Jenna Rychert, E Sue Slechta, Adam P Barker, Edwin Miranda, N Esther Babady, Yi-Wei Tang, Connie Gibas, Nathan Wiederhold, DeAnna Sutton, Kimberly E Hanson
Invasive fungal infections are an important cause of morbidity and mortality affecting primarily immunocompromised patients. While fungal identification to the species level is critical to providing appropriate therapy, it can be slow, laborious, and often relies on subjective morphologic criteria. The use of MALDI-TOF mass spectrometry has the potential to speed up and improve the accuracy of identification. In this multi-center study, we evaluated the accuracy of the VITEK® MS v3.0 system in identifying 1,601 clinical mold isolates as compared to identification by DNA sequence analysis and supported by morphologic and phenotypic testing...
November 15, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29141211/lateral-preoptic-control-of-the-lateral-habenula-through-convergent-glutamate-and-gaba-transmission
#9
David J Barker, Jorge Miranda-Barrientos, Shiliang Zhang, David H Root, Hui-Ling Wang, Bing Liu, Erin S Calipari, Marisela Morales
The lateral habenula (LHb) is a brain structure that participates in cognitive and emotional processing and has been implicated in several mental disorders. Although one of the largest inputs to the LHb originates in the lateral preoptic area (LPO), little is known about how the LPO participates in the regulation of LHb function. Here, we provide evidence that the LPO exerts bivalent control over the LHb through the convergent transmission of LPO glutamate and γ-aminobutyric acid (GABA) onto single LHb neurons...
November 14, 2017: Cell Reports
https://www.readbyqxmd.com/read/29139607/iatrogenic-arteriovenous-fistula-of-the-breast-following-core-biopsy-presenting-in-pregnancy
#10
Sarah Barker, Michael Ashcroft, Nick Abbott
Core-biopsy of the breast is the standard of care for assessment of breast lumps. It is rarely associated with a vascular injury resulting in the formation of an arteriovenous fistula. Though previously noted in the medical literature, it has never been reported in the context of pregnancy and lactation.
November 15, 2017: Breast Journal
https://www.readbyqxmd.com/read/29139195/phenotypic-characteristics-associated-with-slow-gait-speed-in-idiopathic-pulmonary-fibrosis
#11
Claire M Nolan, Matthew Maddocks, Toby M Maher, Jane L Canavan, Sarah E Jones, Ruth E Barker, Suhani Patel, Joseph Jacob, Paul Cullinan, William D-C Man
BACKGROUND AND OBJECTIVE: Usual gait speed over 4 m (4MGS) is an established functional performance measure in older adults that consistently predicts adverse health outcomes, but few data exist in idiopathic pulmonary fibrosis (IPF). We assessed the reliability of 4MGS, its relationship with established outcome measures and its responsiveness to pulmonary rehabilitation. METHODS: In four prospective IPF cohorts, 4MGS inter-observer (n = 46) and test-retest (n = 46) reliability, concurrent validity (n = 65 and n = 62) and responsiveness (n = 60) were determined...
November 14, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/29132380/addressing-challenges-in-scaling-up-tb-and-hiv-treatment-integration-in-rural-primary-healthcare-clinics-in-south-africa-suthi-a-cluster-randomized-controlled-trial-protocol
#12
Kogieleum Naidoo, Santhanalakshmi Gengiah, Nonhlanhla Yende-Zuma, Nesri Padayatchi, Pierre Barker, Andrew Nunn, Priashni Subrayen, Salim S Abdool Karim
BACKGROUND: A large and compelling clinical evidence base has shown that integrated TB and HIV services leads to reduction in human immunodeficiency virus (HIV)- and tuberculosis (TB)-associated mortality and morbidity. Despite official policies and guidelines recommending TB and HIV care integration, its poor implementation has resulted in TB and HIV remaining the commonest causes of death in several countries in sub-Saharan Africa, including South Africa. This study aims to reduce mortality due to TB-HIV co-infection through a quality improvement strategy for scaling up of TB and HIV treatment integration in rural primary healthcare clinics in South Africa...
November 13, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/29130585/exploring-patient-reported-outcomes-following-percutaneous-coronary-intervention-a-qualitative-study
#13
Darshini R Ayton, Anna L Barker, Geeske M E E Peeters, Danielle E Berkovic, Jeffrey Lefkovits, Angela Brennan, Sue Evans, John Zalcberg, Christopher Reid, Johannes Just Stoelwinder, John McNeil
BACKGROUND: Percutaneous coronary intervention (PCI) is a common cardiac procedure used to treat obstructive coronary artery disease. Patient-centred care is a priority in cardiovascular health having been shown to increase patient satisfaction, engagement with rehabilitation activities and reduce anxiety. Evidence indicates that patient-centred care is best achieved by routine collection of patient-reported outcomes (PROs). However, existing patient-reported outcome measures (PROMs) have limited the patient involvement in their development...
November 12, 2017: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/29129512/thieno-2-3-b-pyridine-derivatives-are-potent-anti-platelet-drugs-inhibiting-platelet-activation-aggregation-and-showing-synergy-with-aspirin
#14
Naif K Binsaleh, Catherine A Wigley, Kathryn A Whitehead, Michelle van Rensburg, Johannes Reynisson, Lisa I Pilkington, David Barker, Sarah Jones, Nina C Dempsey-Hibbert
Drugs which inhibit platelet function are commonly used to prevent blood clot formation in patients with Acute Coronary Syndromes (ACS) or those at risk of stroke. The thieno[3,2-c]pyridine class of therapeutic agents, of which clopidogrel is the most commonly used, target the P2Y12 receptor, and are often used in combination with acetylsalicylic acid (ASA). Six thieno[2,3-b]pyridine were assessed for in vitro anti-platelet activity; all derivatives showed effects on both platelet activation and aggregation, and showed synergy with ASA...
November 7, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29124290/predicting-psychiatric-readmission-sex-specific-models-to-predict-30-day-readmission-following-acute-psychiatric-hospitalization
#15
Lucy Church Barker, Andrea Gruneir, Kinwah Fung, Nathan Herrmann, Paul Kurdyak, Elizabeth Lin, Paula A Rochon, Dallas Seitz, Valerie H Taylor, Simone N Vigod
PURPOSE: Psychiatric readmission is a common negative outcome. Predictors of readmission may differ by sex. This study aimed to derive and internally validate sex-specific models to predict 30-day psychiatric readmission. METHODS: We used population-level health administrative data to identify predictors of 30-day psychiatric readmission among women (n = 33,353) and men (n = 32,436) discharged from all psychiatric units in Ontario, Canada (2008-2011). Predictor variables included sociodemographics, health service utilization, and clinical characteristics...
November 9, 2017: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/29121495/energy-expenditure-growth-and-nutritional-therapy-in-appropriate-and-small-for-gestational-age-preterm-infants
#16
Andrea Dunshee de Abranches, Fernanda Valente Mendes Soares, Letícia Duarte Villela, Maria Dalva Barbosa Barker Méio, Olivia Araújo Zin, Saint-Clair Gomes Junior, Maria Elisabeth Lopes Moreira
OBJECTIVE: To evaluate the resting energy expenditure, growth, and quantity of energy and macronutrients intake in a group of preterm newborns. METHODS: The cohort study was performed with appropriate and small for gestational age preterm infants (birth weight lower than 1500g or gestational age<32 weeks). Resting energy expenditure was measured using indirect calorimetry on the 7th, 14th, 21st, and 28th days of life, and at discharge. Length, head circumference and body weight were assessed weekly...
November 6, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/29118648/data-release-dna-barcodes-of-plant-species-collected-for-the-global-genome-initiative-for-gardens-program-national-museum-of-natural-history-smithsonian-institution
#17
Jose D Zúñiga, Morgan R Gostel, Daniel G Mulcahy, Katharine Barker, Asia Hill, Maryam Sedaghatpour, Samantha Q Vo, Vicki A Funk, Jonathan A Coddington
The Global Genome Initiative has sequenced and released 1961 DNA barcodes for genetic samples obtained as part of the Global Genome Initiative for Gardens Program. The dataset includes barcodes for 29 plant families and 309 genera that did not have sequences flagged as barcodes in GenBank and sequences from officially recognized barcoding genetic markers meet the data standard of the Consortium for the Barcode of Life. The genetic samples were deposited in the Smithsonian Institution's National Museum of Natural History Biorepository and their records were made public through the Global Genome Biodiversity Network's portal...
2017: PhytoKeys
https://www.readbyqxmd.com/read/29118256/survey-of-knowledge-beliefs-and-behaviors-of-migrant-vietnamese-parents-regarding-young-children-s-oral-health
#18
Uyen N Nguyen, Dorothy J Rowe, Judith C Barker
Purpose: The purpose of this study was to investigate the oral health knowledge, beliefs, and behaviors of migrant Vietnamese parents of 1-5 year-olds in San Jose, California.Method: A verbally-administered survey was conducted with a convenience sample of 45 Vietnamese parents recruited at San Jose public libraries. Following preliminary screening, written informed consent was obtained from eligible individuals. A pre-tested, structured 94-item questionnaire was used to collect information regarding parent demographics, and the parent's knowledge, beliefs, and behaviors about children's oral health...
April 2017: Journal of Dental Hygiene: JDH
https://www.readbyqxmd.com/read/29117105/efficacy-of-web-based-weight-loss-maintenance-programs-a-randomized-controlled-trial-comparing-standard-features-versus-the-addition-of-enhanced-personalized-feedback-over-12-months
#19
Clare E Collins, Philip J Morgan, Melinda J Hutchesson, Christopher Oldmeadow, Daniel Barker, Robin Callister
Few randomized controlled trials (RCT) have evaluated the efficacy of web-based programs targeting maintenance of lost weight. The aims of this study were to evaluate two versions of a commercially available web-based weight loss maintenance (WLM) program and examine whether the provision of enhanced feedback was associated with better WLM. The study was an assessor-blinded RCT of change in body mass index (BMI) over 12 months WLM. Participants were 227 adults (44% male, 42.3 ± 10.1 years, BMI 30.4 ± 4.1 kg/m²) randomized to either a basic (Basic WLM) or enhanced program with additional support (Enhanced WLM)...
November 8, 2017: Behavioral Sciences
https://www.readbyqxmd.com/read/29115288/child-environmental-exposures-to-water-and-sand-at-the-beach-findings-from-studies-of-over-68-000-subjects-at-12-beaches
#20
Stephanie DeFlorio-Barker, Benjamin F Arnold, Elizabeth A Sams, Alfred P Dufour, John M Colford, Steven B Weisberg, Kenneth C Schiff, Timothy J Wade
Swimming and recreating in lakes, oceans, and rivers is common, yet the literature suggests children may be at greater risk of illness following such exposures. These effects might be due to differences in immunity or differing behavioral factors such as poorer hygiene, longer exposures to, and greater ingestion of potentially contaminated water and sand. We pooled data from 12 prospective cohorts (n=68,685) to examine exposures to potentially contaminated media such as beach water and sand among children compared with adults, and conducted a simulation using self-reported time spent in the water and volume of water swallowed per minute by age to estimate the total volume of water swallowed per swimming event by age category...
November 8, 2017: Journal of Exposure Science & Environmental Epidemiology
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