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https://www.readbyqxmd.com/read/30011777/the-american-association-for-thoracic-surgery-consensus-guidelines-on-bicuspid-aortic-valve-related-aortopathy-full-online-only-version
#1
Michael A Borger, Paul W M Fedak, Elizabeth H Stephens, Thomas G Gleason, Evaldas Girdauskas, John S Ikonomidis, Ali Khoynezhad, Samuel C Siu, Subodh Verma, Michael D Hope, Duke E Cameron, Donald F Hammer, Joseph S Coselli, Marc R Moon, Thoralf M Sundt, Alex J Barker, Michael Markl, Alessandro Della Corte, Hector I Michelena, John A Elefteriades
Bicuspid aortic valve disease is the most common congenital cardiac disorder, being present in 1% to 2% of the general population. Associated aortopathy is a common finding in patients with bicuspid aortic valve disease, with thoracic aortic dilation noted in approximately 40% of patients in referral centers. Several previous consensus statements and guidelines have addressed the management of bicuspid aortic valve-associated aortopathy, but none focused entirely on this disease process. The current guidelines cover all major aspects of bicuspid aortic valve aortopathy, including natural history, phenotypic expression, histology and molecular pathomechanisms, imaging, indications for surgery, surveillance, and follow-up, and recommendations for future research...
August 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/30011756/the-american-association-for-thoracic-surgery-consensus-guidelines-on-bicuspid-aortic-valve-related-aortopathy-executive-summary
#2
Michael A Borger, Paul W M Fedak, Elizabeth H Stephens, Thomas G Gleason, Evaldas Girdauskas, John S Ikonomidis, Ali Khoynezhad, Samuel C Siu, Subodh Verma, Michael D Hope, Duke E Cameron, Donald F Hammer, Joseph S Coselli, Marc R Moon, Thoralf M Sundt, Alex J Barker, Michael Markl, Alessandro Della Corte, Hector I Michelena, John A Elefteriades
Bicuspid aortic valve disease is a common congenital cardiac disorder, being present in 1% to 2% of the general population. Associated aortopathy is a common finding in patients with bicuspid aortic valve disease, with thoracic aortic dilation noted in approximately 40% of patients in referral centers. Several previous consensus statements and guidelines have addressed the management of bicuspid aortic valve-associated aortopathy, but none focused entirely on this disease process. The current document is an executive summary of "The American Association for Thoracic Surgery Guidelines on Bicuspid Aortic Valve-Related Aortopathy...
August 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/30011306/time-course-of-traumatic-neuroma-development
#3
Karla M C Oliveira, Lukas Pindur, Zhihua Han, Mit B Bhavsar, John H Barker, Liudmila Leppik
This study was designed to characterize morphologic stages during neuroma development post amputation with an eye toward developing better treatment strategies that intervene before neuromas are fully formed. Right forelimbs of 30 Sprague Dawley rats were amputated and limb stumps were collected at 3, 7, 28, 60 and 90 Days Post Amputation (DPA). Morphology of newly formed nerves and neuromas were assessed via general histology and neurofilament protein antibody staining. Analysis revealed six morphological characteristics during nerve and neuroma development; 1) normal nerve, 2) degenerating axons, 3) axonal sprouts, 4) unorganized bundles of axons, 5) unorganized axon growth into muscles, and 6) unorganized axon growth into fibrotic tissue (neuroma)...
2018: PloS One
https://www.readbyqxmd.com/read/30011101/understanding-the-profile-of-personal-alert-victoria-clients-who-fall
#4
Sze-Ee Soh, Darshini Ayton, Renata Morello, Aleksandra Natora, Sarah Yallop, Anna Barker
Personal response systems are used to support frail, older people, and people with disabilities to live independently in their own homes. This paper describes the patterns, characteristics, and outcomes of Personal Alert Victoria (PAV) clients who experience a fall. It also examines the current falls prevention referral practices of assessors who determine whether an older person would benefit from a personal response system. Deidentified data on clients from the PAV service provider from 2012 to 2014 were linked to routine data maintained by the Department of Health and Human Services in Victoria...
July 16, 2018: Health & Social Care in the Community
https://www.readbyqxmd.com/read/30010756/adjuvant-bevacizumab-for-melanoma-patients-at-high-risk-of-recurrence-survival-analysis-of-the-avast-m-trial
#5
P G Corrie, A Marshall, P D Nathan, P Lorigan, M Gore, S Tahir, G Faust, C G Kelly, M Marples, S J Danson, E Marshall, S J Houston, R E Board, A M Waterston, J P Nobes, M Harries, S Kumar, A Goodman, A Dalgleish, A Martin-Clavijo, S Westwell, R Casasola, D Chao, A Maraveyas, P M Patel, C H Ottensmeier, D Farrugia, A Humphreys, B Eccles, G Young, E O Barker, C Harman, M Weiss, K A Myers, A Chhabra, S H Rodwell, J A Dunn, M R Middleton
Background: Bevacizumab is a recombinant humanised monoclonal antibody to vascular endothelial growth factor (VEGF) shown to improve survival in advanced solid cancers. We evaluated the role of adjuvant bevacizumab in melanoma patients at high risk of recurrence. Patients and Methods: Patients with resected AJCC stage IIB, IIC and III cutaneous melanoma were randomised to receive either adjuvant bevacizumab (7.5 mg/kg IV 3 weekly for 1 year) or standard observation...
July 13, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/30009983/microfluidic-assisted-nanoprecipitation-of-pegylated-poly-d-l-lactic-acid-co-caprolactone-effect-of-macromolecular-and-microfluidic-parameters-on-particle-size-and-paclitaxel-encapsulation
#6
Enrique Lallana, Roberto Donno, Davide Magrì, Katie Barker, Zahid Nazir, Kevin Treacher, M Jayne Lawrence, Marianne Ashford, Nicola Tirelli
In this work we evaluate the effect of polymer composition and architecture of (PEGylated) polyesters on particle size and paclitaxel (PTX) loading for particles manufactured via microfluidic-assisted, continuous-flow nanoprecipitation using two microfluidic chips with different geometries and mixing principles. We have prepared poly (d,l-lactic acid-co-caprolactone) (PLCL) from ring-opening polymerization (ROP) of LA and CL mixtures and different (macro) initiators (namely, 1-dodecanol, a MeO-PEG-OH, and a 4-armed star PEG-OH), rendering polyesters that vary in monomer composition (i...
July 12, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/30007367/increased-burden-of-suicidality-among-young-street-involved-sex-workers-who-use-drugs-in-vancouver-canada
#7
Brittany Barker, Scott E Hadland, Huiru Dong, Kate Shannon, Thomas Kerr, Kora DeBeck
Background: The risks of suicidality among street-involved youth who use drugs and engage in sex work are not well described. This study sought to evaluate if street-involved youth who engage in sex work were at an elevated risk for attempting suicide. Methods: Data were derived from the At-Risk Youth Study, a prospective cohort of street-involved youth who use drugs in Vancouver, Canada. Multivariable generalized estimating equation analyses were employed to examine whether youth who engaged in sex work were at elevated risk of attempting suicide, controlling for possible confounders...
July 11, 2018: Journal of Public Health
https://www.readbyqxmd.com/read/30006439/irf5-is-increased-in-laboring-myometrium-and-regulates-pro-labor-mediators
#8
Ratana Lim, Gillian Barker, Martha Lappas
Preterm birth continues to be the leading cause of neonatal mortality and morbidities that can extend into adult life. Few treatment options stem from our incomplete understanding of the mechanisms of human labor and delivery. Activation of the inflammatory response in gestational tissues by inflammation and/or infection leads to the production of pro-inflammatory and pro-labor mediators, thus preterm birth. Interferon regulatory factor 5 (IRF5) has recently emerged as an important pro-inflammatory transcription factor involved in acute and chronic inflammation...
July 13, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/30004811/non-invasive-wave-intensity-analysis-predicts-functional-worsening-in-children-with-pulmonary-arterial-hypertension
#9
Michal Schafer, Neil Wilson, D Dunbar Ivy, Richard Ing, Steven H Abman, Lorna Browne, Gareth Morgan, Michael Ross, Daniel McLennan, Alex Barker, Brian Fonseca, Michael Di Maria, Kendall S Hunter, Uyen Truong
The purpose of this study was to characterize the pulmonary vascular stiffness using wave intensity analysis (WIA) in children with pulmonary arterial hypertension (PAH), compare the WIA indices with catheterization and MRI derived hemodynamics, and assess the prognostic ability of WIA derived biomarkers to predict the functional worsening. WIA was performed in children with PAH (n=40) and healthy controls (n=15) from phase-contrast MRI derived flow and area waveforms in the main pulmonary artery. From comprehensive WIA spectra, we collected and compared with healthy controls forward compression waves (FCW), backward compression waves (BCW), forward decompression waves (FDW), and wave propagation speed (c-MPA)...
July 13, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/30004780/spin-isomer-conversion-of-water-at-room-temperature-and-quantum-rotor-induced-nuclear-polarization-in-the-water-endofullerene-h_-2-o-c_-60
#10
Benno Meier, Karel Kouřil, Christian Bengs, Hana Kouřilová, Timothy C Barker, Stuart J Elliott, Shamim Alom, Richard J Whitby, Malcolm H Levitt
Water exists in two forms, para and ortho, that have nuclear spin states with different symmetries. Here we report the conversion of fullerene-encapsulated para water to ortho water. The enrichment of para water at low temperatures is monitored via changes in the electrical polarizability of the material. Upon rapid dissolution of the material in toluene the excess para water converts to ortho water. In H_{2}^{16}O@C_{60} the conversion leads to a slow increase in the NMR signal. In H_{2}^{17}O@C_{60} the conversion gives rise to weak signal enhancements attributed to quantum-rotor-induced nuclear spin polarization...
June 29, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/30004542/real-time-in-situ-dynamic-sub-surface-imaging-of-multi-component-electrodeposited-films-using-event-mode-neutron-reflectivity
#11
A Robert Hillman, Robert Barker, Robert M Dalgliesh, Virginia C Ferreira, Emma J R Palin, Rachel M Sapstead, Emma L Smith, Nina-Juliane Steinke, Karl S Ryder, Andrew D Ballantyne
Exquisite control of the electrodeposition of metal films and coatings is critical to a number of high technology and manufacturing industries, delivering functionality as diverse as anti-corrosion and anti-wear coatings, electronic device interconnects and energy storage. The frequent involvement of more than one metal motivates the capability to control, maintain and monitor spatial disposition of the component metals, whether as multilayers, alloys or composites. Here we investigate the deposition, evolution and dissolution of single and two-component metal layers involving Ag, Cu, and Sn on Au substrates immersed in the deep eutectic solvent (DES) Ethaline...
July 13, 2018: Faraday Discussions
https://www.readbyqxmd.com/read/30003879/talin-is-a-substrate-for-sumoylation-in-migrating-cancer-cells
#12
Zhiyao Huang, Diana Barker, Jonathan M Gibbins, Philip R Dash
Focal adhesions (FAs) play an important role in cancer cell migration and metastasis by linking the actin cytoskeleton to the extracellular matrix, allowing the cell to generate traction. SUMOylation is a post-translational modification of proteins on lysine residues that can affect protein localisation, turnover and protein-protein interactions. In this study, we demonstrate that talin, a key component of FAs, can be post-translationally modified by SUMOylation in MDA-MB-231 breast cancer cells and U2OS osteosarcoma cells...
July 9, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/30003381/analysis-of-oxygen-uptake-efficiency-parameters-in-young-people-with-cystic-fibrosis
#13
Owen W Tomlinson, Alan R Barker, Lucy V Chubbock, Daniel Stevens, Zoe L Saynor, Patrick J Oades, Craig A Williams
PURPOSE: This study characterised oxygen uptake efficiency (OUE) in children with mild-to-moderate cystic fibrosis (CF). Specifically, it investigated (1) the utility of OUE parameters as potential submaximal surrogates of peak oxygen uptake ([Formula: see text]), and (2) the relationship between OUE and disease severity. METHODS: Cardiopulmonary exercise test (CPET) data were collated from 72 children [36 CF, 36 age- and sex-matched controls (CON)], with OUE assessed as its highest 90-s average (plateau; OUEP), the gas exchange threshold (OUEGET ) and respiratory compensation point (OUERCP )...
July 12, 2018: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29999186/the-role-of-birth-weight-on-the-causal-pathway-to-child-and-adolescent-adhd-symptomatology-a-population-based-twin-differences-longitudinal-design
#14
Kai Xiang Lim, Chao-Yu Liu, Tabea Schoeler, Charlotte A M Cecil, Edward D Barker, Essi Viding, Corina U Greven, Jean-Baptiste Pingault
BACKGROUND: Available evidence points towards lower birth weight as a risk factor for the development of attention deficit/hyperactivity disorder (ADHD) symptoms. We probed the causal nature of this putative effect of birth weight on ADHD symptoms using the twin differences design, which accounts for genetic and shared environmental confounds. METHOD: In a large population-based twin sample - 3,499 monozygotic (MZ) and 6,698 dizygotic (DZ) pairs - parents, teachers or twins rated the twins' ADHD symptoms at nine assessment waves (2-16 years)...
July 12, 2018: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/29998476/mechanisms-of-blood-pressure-control-following-acute-exercise-in-adolescents-effects-of-exercise-intensity-on-haemodynamics-and-baroreflex-sensitivity
#15
Ricardo Oliveira, Alan R Barker, Florian Debras, Alexandra O'Doherty, Craig A Williams
NEW FINDINGS: What is the central question of this study? What are the autonomic and vascular components of the baroreflex during hypotension following different exercise intensities in adolescents? What is the main finding and its importance? Hypotension after high-intensity exercise lasted 60 min, whereas following moderate-intensity exercise, blood pressure was restored after 20 min. Stroke volume and peripheral resistance responses were different between intensities. Post both exercise intensities, baroreflex sensitivity was lowered mainly due to the autonomic component, which returned to baseline 60 min post-exercise...
July 11, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29996088/a-neural-circuit-underlying-the-generation-of-hot-flushes
#16
Stephanie L Padilla, Christopher W Johnson, Forrest D Barker, Michael A Patterson, Richard D Palmiter
Hot flushes are a sudden feeling of warmth commonly associated with the decline of gonadal hormones at menopause. Neurons in the arcuate nucleus of the hypothalamus that express kisspeptin and neurokinin B (Kiss1ARH neurons) are candidates for mediating hot flushes because they are negatively regulated by sex hormones. We used a combination of genetic and viral technologies in mice to demonstrate that artificial activation of Kiss1ARH neurons evokes a heat-dissipation response resulting in vasodilation (flushing) and a corresponding reduction of core-body temperature in both females and males...
July 10, 2018: Cell Reports
https://www.readbyqxmd.com/read/29991383/gonorrhoea-treatment-failure-caused-by-a-neisseria-gonorrhoeae-strain-with-combined-ceftriaxone-and-high-level-azithromycin-resistance-england-february-2018
#17
David W Eyre, Nicholas D Sanderson, Emily Lord, Natasha Regisford-Reimmer, Kevin Chau, Leanne Barker, Markus Morgan, Robert Newnham, Daniel Golparian, Magnus Unemo, Derrick W Crook, Tim Ea Peto, Gwenda Hughes, Michelle J Cole, Helen Fifer, Anne Edwards, Monique I Andersson
We describe a gonorrhoea case with combined high-level azithromycin resistance and ceftriaxone resistance. In February 2018, a heterosexual male was diagnosed with gonorrhoea in the United Kingdom following sexual intercourse with a locally resident female in Thailand and failed treatment with ceftriaxone plus doxycycline and subsequently spectinomycin. Resistance arose from two mechanisms combining for the first time in a genetic background similar to a commonly circulating strain. Urgent action is essential to prevent further spread...
July 2018: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/29991341/n-n-dimethyltryptamine-facts-and-myths
#18
Steven A Barker
No abstract text is available yet for this article.
July 2018: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29989208/targeting-wnt-signaling-pseudokinases-in-hematological-cancers
#19
REVIEW
Hanna Karvonen, Robert Perttilä, Wilhelmiina Niininen, Harlan Barker, Daniela Ungureanu
Recent studies showed that several pseudokinases from the receptor tyrosine kinase family are important players in regulating cancer cell invasion, metastasis and drug-resistance, suggesting that targeting these proteins can play a therapeutic role in cancer treatment. Receptor Tyr kinase-like orphan receptors (RORs), protein Tyr kinase 7 (PTK7) (also called colon carcinoma kinase 4 (CCK4)), and receptor-like Tyr kinase (RYK) are Wnt ligand binding receptors within the non-canonical Wnt signaling, with important roles in development, tissue homeostasis and organogenesis...
July 10, 2018: European Journal of Haematology
https://www.readbyqxmd.com/read/29988953/node-pore-coded-coincidence-correction-coulter-counters-code-design-and-sparse-deconvolution
#20
Michael Kellman, Francois Rivest, Alina Pechacek, Lydia Sohn, Michael Lustig
We present a novel method to perform individual particle (e.g. cells or viruses) coincidence correction through joint channel design and algorithmic methods. Inspired by multiple-user communication theory, we modulate the channel response, with Node-Pore Sensing, to give each particle a binary Barker code signature. When processed with our modified successive interference cancellation method, this signature enables both the separation of coincidence particles and a high sensitivity to small particles. We identify several sources of modeling error and mitigate most effects using a data-driven self-calibration step and robust regression...
April 15, 2018: IEEE Sensors Journal
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