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https://www.readbyqxmd.com/read/27910965/notable-deals-in-the-pharmaceutical-industry-in-the-third-quarter-of-2016
#1
E Cruces
During the third quarter of 2016, Cortellis Competitive Intelligence had 865 new deals added as part of its ongoing coverage of pharmaceutical licensing activity. This figure shows similar deal activity compared with the same quarter of 2015 (934), and 21% less than the previous quarter, although they had similar disclosed financial sizes in comparison with the first half of 2016. This article will focus on a number of the most valuable and notable deals forged during the quarter, as well as a selection of deals from some of the most prolific deal makers...
October 2016: Drugs of Today
https://www.readbyqxmd.com/read/27910739/overview-on-therapeutic-applications-of-microparticulate-drug-delivery-systems
#2
Swarna Bale, Amit Khurana, A Shiva Shankar Reddy, Mandip Singh, Chandraiah Godugu
Research in novel drug delivery systems is being explored competitively in order to attain maximum therapeutic effect while minimizing the adverse effects. Despite several advancements in pharmaceutical formulations, one of the major challenges still persisting is sustained drug release. Microencapsulation enacts as an intelligent approach with a strong therapeutic impact and is in demand globally in medical technology due to its specific and attractive properties, including biocompatibility, stability, target specificity, uniform encapsulation, better compliance, and controlled and sustained release patterns that are responsible for diminishing the toxicity and dosage frequency...
2016: Critical Reviews in Therapeutic Drug Carrier Systems
https://www.readbyqxmd.com/read/27881894/competition-related-factors-directly-influence-preferences-for-facial-cues-of-dominance-in-allies
#3
Christopher D Watkins, Benedict C Jones
ABSTRACT: Alliance formation is a critical dimension of social intelligence in political, social and biological systems. As some allies may provide greater "leverage" than others during social conflict, the cognitive architecture that supports alliance formation in humans may be shaped by recent experience, for example in light of the outcomes of violent or non-violent forms intrasexual competition. Here we used experimental priming techniques to explore this issue. Consistent with our predictions, while men's preferences for dominant allies strengthened following losses (compared to victories) in violent intrasexual contests, women's preferences for dominant allies weakened following losses (compared to victories) in violent intrasexual contests...
2016: Behavioral Ecology and Sociobiology
https://www.readbyqxmd.com/read/27815130/informational-masking-and-the-effects-of-differences-in-fundamental-frequency-and-fundamental-frequency-contour-on-phonetic-integration-in-a-formant-ensemble
#4
Robert J Summers, Peter J Bailey, Brian Roberts
This study explored the effects on speech intelligibility of across-formant differences in fundamental frequency (ΔF0) and F0 contour. Sentence-length speech analogues were presented dichotically (left=F1+F3; right=F2), either alone or-because competition usually reveals grouping cues most clearly-accompanied in the left ear by a competitor for F2 (F2C) that listeners must reject to optimize recognition. F2C was created by inverting the F2 frequency contour. In experiment 1, all left-ear formants shared the same constant F0 and ΔF0F2 was 0 or ±4 semitones...
November 1, 2016: Hearing Research
https://www.readbyqxmd.com/read/27762047/a-responsive-battery-with-controlled-energy-release
#5
Xiaopeng Wang, Jian Gao, Zhihua Cheng, Nan Chen, Liangti Qu
A new type of responsive battery with the fascinating feature of pressure perceptibility has been developed, which can spontaneously, timely and reliably control the power outputs (e.g., current and voltage) in response to pressure changes. The device design is based on the structure of the Zn-air battery, in which graphene-coated sponge serves as pressure-sensitive air cathode that endows the whole system with the capability of self-controlled energy release. The responsive batteries exhibit superior battery performance with high open-circuit voltage (1...
November 14, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27757452/spatial-organization-based-reciprocal-switching-of-enzyme-free-nucleic-acid-circuits
#6
Yidan Tang, Zhentong Zhu, Baiyang Lu, Bingling Li
We report a new nucleic acid sensing strategy through an intelligent design of spatial organization based reciprocal switching of catalytic hairpin assembly (CHA). The so-called SORS-CHA not only turns a well-designed CHA circuit into a relatively universal detector for any targeting sequence, but also guarantees a much enhanced signal resolution and a believability to minimize the misreading induced by unexpected signal drifts. With more trustworthy results, but a simpler sequence design, nucleic acid circuits could become competitive in real-world applications...
October 19, 2016: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/27757379/tourism-guide-cloud-service-quality-what-actually-delights-customers
#7
Shu-Ping Lin, Chen-Lung Yang, Han-Chung Pi, Thao-Minh Ho
BACKGROUND: The emergence of advanced IT and cloud services has beneficially supported the information-intensive tourism industry, simultaneously caused extreme competitions in attracting customers through building efficient service platforms. On response, numerous nations have implemented cloud platforms to provide value-added sightseeing information and personal intelligent service experiences. Despite these efforts, customers' actual perspectives have yet been sufficiently understood...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27722214/notable-deals-in-the-pharmaceutical-industry-in-the-second-quarter-of-2016
#8
P D'Souza
During the second quarter of 2016, Cortellis Competitive Intelligence had 1,014 new deals added as part of its ongoing coverage of pharmaceutical licensing activity. This was on par with the last quarter (1,011) and a substantial increase on the same quarter for the previous 1 year (659). This article will focus on highlighting a number of the most valuable and notable deals forged during the quarter, as well as a selection of deals from some of the most prolific deal makers. An update on milestone, options and terminated deals of significance will also be presented, along with an early outlook on the next quarter's pharmaceutical licensing activity...
August 2016: Drugs of Today
https://www.readbyqxmd.com/read/27722213/notable-deals-in-the-pharmaceutical-industry-in-the-first-quarter-of-2016
#9
E Cruces
During the first quarter of 2016, Cortellis Competitive Intelligence had 1,011 new deals added as part of its ongoing coverage of pharmaceutical licensing activity. This was a slight decrease on the last quarter (Q4 2015: 1,075) but a significant increase on the same quarter for the previous year (Q1 2015: 826). This article will focus on highlighting a number of the most valuable and notable deals forged during the quarter, as well as a selection of deals from some of the most prolific deal makers. An update on milestone, options and terminated deals of significance will also be presented, along with an early outlook on the next quarter's pharmaceutical licensing activity...
August 2016: Drugs of Today
https://www.readbyqxmd.com/read/27698662/a-novel-hybrid-clonal-selection-algorithm-with-combinatorial-recombination-and-modified-hypermutation-operators-for-global-optimization
#10
Weiwei Zhang, Jingjing Lin, Honglei Jing, Qiuwen Zhang
Artificial immune system is one of the most recently introduced intelligence methods which was inspired by biological immune system. Most immune system inspired algorithms are based on the clonal selection principle, known as clonal selection algorithms (CSAs). When coping with complex optimization problems with the characteristics of multimodality, high dimension, rotation, and composition, the traditional CSAs often suffer from the premature convergence and unsatisfied accuracy. To address these concerning issues, a recombination operator inspired by the biological combinatorial recombination is proposed at first...
2016: Computational Intelligence and Neuroscience
https://www.readbyqxmd.com/read/27627313/effects-of-competition-and-cooperation-interaction-between-agents-on-networks-in-the-presence-of-a-market-capacity
#11
A Sonubi, A Arcagni, S Stefani, M Ausloos
A network effect is introduced taking into account competition, cooperation, and mixed-type interaction among agents along a generalized Verhulst-Lotka-Volterra model. It is also argued that the presence of a market capacity undoubtedly enforces a definite limit on the agent's size growth. The state stability of triadic agents, i.e., the most basic network plaquette, is investigated analytically for possible scenarios, through a fixed-point analysis. It is discovered that: (i) market demand is only satisfied for full competition when one agent monopolizes the market; (ii) growth of agent size is encouraged in full cooperation; (iii) collaboration among agents to compete against one single agent may result in the disappearance of this single agent out of the market; and (iv) cooperating with two rivals may become a growth strategy for an intelligent agent...
August 2016: Physical Review. E
https://www.readbyqxmd.com/read/27607882/discovery-of-the-aryl-heterocyclic-amine-aha-insecticides-synthesis-insecticidal-activity-field-results-mode-of-action-and-bioavailability-of-a-leading-field-candidate
#12
William H Dent, Mark A Pobanz, Chaoxian Geng, Thomas C Sparks, Gerald B Watson, Theodore J Letherer, Kenneth W Beavers, Cathy D Young, Yelena A Adelfinskaya, Ronald R Ross, Greg Whiteker, James Renga
BACKGROUND: Gamma-amino butyric acid (GABA) antagonists are proven targets for control of Lepidopteran and other pests. New heterocyclic compounds with high insecticidal activity were discovered using a competitive-intelligence inspired scaffold hopping approach to generate analogs of fipronil, a known GABA antagonist. These novel aryl heterocyclic amines (AHA's) displayed broad spectrum activity on a number of chewing insect pests. RESULTS: Through >370 modifications of the core AHA structure, a 7-pyrazolopyridine lead molecule was found to exhibit much improved activity on a number of insect pests...
September 8, 2016: Pest Management Science
https://www.readbyqxmd.com/read/27586751/across-formant-integration-and-speech-intelligibility-effects-of-acoustic-source-properties-in-the-presence-and-absence-of-a-contralateral-interferer
#13
Robert J Summers, Peter J Bailey, Brian Roberts
The role of source properties in across-formant integration was explored using three-formant (F1+F2+F3) analogues of natural sentences (targets). In experiment 1, F1+F3 were harmonic analogues (H1+H3) generated using a monotonous buzz source and second-order resonators; in experiment 2, F1+F3 were tonal analogues (T1+T3). F2 could take either form (H2 or T2). Target formants were always presented monaurally; the receiving ear was assigned randomly on each trial. In some conditions, only the target was present; in others, a competitor for F2 (F2C) was presented contralaterally...
August 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27579323/hybrid-binary-imperialist-competition-algorithm-and-tabu-search-approach-for-feature-selection-using-gene-expression-data
#14
Shuaiqun Wang, Aorigele, Wei Kong, Weiming Zeng, Xiaomin Hong
Gene expression data composed of thousands of genes play an important role in classification platforms and disease diagnosis. Hence, it is vital to select a small subset of salient features over a large number of gene expression data. Lately, many researchers devote themselves to feature selection using diverse computational intelligence methods. However, in the progress of selecting informative genes, many computational methods face difficulties in selecting small subsets for cancer classification due to the huge number of genes (high dimension) compared to the small number of samples, noisy genes, and irrelevant genes...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27528758/the-quantum-mitochondrion-and-optimal-health
#15
REVIEW
Alistair V W Nunn, Geoffrey W Guy, Jimmy D Bell
A sufficiently complex set of molecules, if subject to perturbation, will self-organize and show emergent behaviour. If such a system can take on information it will become subject to natural selection. This could explain how self-replicating molecules evolved into life and how intelligence arose. A pivotal step in this evolutionary process was of course the emergence of the eukaryote and the advent of the mitochondrion, which both enhanced energy production per cell and increased the ability to process, store and utilize information...
August 15, 2016: Biochemical Society Transactions
https://www.readbyqxmd.com/read/27521768/restarting-and-recentering-genetic-algorithm-variations-for-dna-fragment-assembly-the-necessity-of-a-multi-strategy-approach
#16
James Alexander Hughes, Sheridan Houghten, Daniel Ashlock
DNA Fragment assembly - an NP-Hard problem - is one of the major steps in of DNA sequencing. Multiple strategies have been used for this problem, including greedy graph-based algorithms, deBruijn graphs, and the overlap-layout-consensus approach. This study focuses on the overlap-layout-consensus approach. Heuristics and computational intelligence methods are combined to exploit their respective benefits. These algorithm combinations were able to produce high quality results surpassing the best results obtained by a number of competitive algorithms specially designed and tuned for this problem on thirteen of sixteen popular benchmarks...
August 10, 2016: Bio Systems
https://www.readbyqxmd.com/read/27448381/snapvideo-personalized-video-generation-for-a-sightseeing-trip
#17
Luming Zhang, Peiguang Jing, Yuting Su, Chao Zhang, Ling Shao
Leisure tourism is an indispensable activity in urban people's life. Due to the popularity of intelligent mobile devices, a large number of photos and videos are recorded during a trip. Therefore, the ability to vividly and interestingly display these media data is a useful technique. In this paper, we propose SnapVideo, a new method that intelligently converts a personal album describing of a trip into a comprehensive, aesthetically pleasing, and coherent video clip. The proposed framework contains three main components...
July 19, 2016: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/27392341/show-and-tell-lessons-learned-from-the-2015-mscoco-image-captioning-challenge
#18
Oriol Vinyals, Alexander Toshev, Samy Bengio, Dumitru Erhan
Automatically describing the content of an image is a fundamental problem in artificial intelligence that connects computer vision and natural language processing. In this paper, we present a generative model based on a deep recurrent architecture that combines recent advances in computer vision and machine translation and that can be used to generate natural sentences describing an image. The model is trained to maximize the likelihood of the target description sentence given the training image. Experiments on several datasets show the accuracy of the model and the fluency of the language it learns solely from image descriptions...
July 7, 2016: IEEE Transactions on Pattern Analysis and Machine Intelligence
https://www.readbyqxmd.com/read/27313604/an-artificial-intelligence-system-to-predict-quality-of-service-in-banking-organizations
#19
Mauro Castelli, Luca Manzoni, Aleš Popovič
Quality of service, that is, the waiting time that customers must endure in order to receive a service, is a critical performance aspect in private and public service organizations. Providing good service quality is particularly important in highly competitive sectors where similar services exist. In this paper, focusing on banking sector, we propose an artificial intelligence system for building a model for the prediction of service quality. While the traditional approach used for building analytical models relies on theories and assumptions about the problem at hand, we propose a novel approach for learning models from actual data...
2016: Computational Intelligence and Neuroscience
https://www.readbyqxmd.com/read/27304969/can-rhesus-monkey-learn-executive-attention
#20
Jessica Bramlett-Parker, David A Washburn
A growing body of data indicates that, compared to humans, rhesus monkeys perform poorly on tasks that assess executive attention, or voluntary control over selection for processing, particularly under circumstances in which attention is attracted elsewhere by competing stimulus control. In the human-cognition literature, there are hotly active debates about whether various competencies such as executive attention, working memory capacity, and fluid intelligence can be improved through training. In the current study, rhesus monkeys (Macaca mulatta) completed an attention-training intervention including several inhibitory-control tasks (a Simon task, numerical Stroop task, global/local interference task, and a continuous performance task) to determine whether generalized improvements would be observed on a version of the Attention Network Test (ANT) of controlled attention, which was administered before and after the training intervention...
June 13, 2016: Behavioral Sciences
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