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https://www.readbyqxmd.com/read/29161804/importance-of-biological-ultrafine-particles-in-indoor-dust-as-a-pathogenesis-of-chronic-inflammatory-lung-diseases
#1
Young-Koo Jee, Jinho Yang, Yoon-Keun Kim, You-Young Kim, Tae Soo Kang
The role of infectious agents in the etiology of inflammatory diseases once believed to be non-infectious is increasingly being recognized. Many bacterial components in the indoor dust can evoke inflammatory lung diseases. Bacteria secrete nanometer-sized vesicles into the extracellular milieu, so-called extracellular vesicles (EVs). which are pathophysiologically related to inflammatory diseases. Microbiota compositions in the indoor dust revealed the presence of both gram-negative and gram-positive bacteria...
November 17, 2017: Environmental Health and Toxicology
https://www.readbyqxmd.com/read/29161802/the-impact-of-surgical-timing-on-pathologic-tumor-response-after-short-course-and-long-course-preoperative-chemoradiation-for-locally-advanced-rectal-adenocarcinoma
#2
Sea-Won Lee, Jong Hoon Lee, In Kyu Lee, Seong Taek Oh, Dae Yong Kim, Tae Hyun Kim, Jae Hwan Oh, Ji Yeon Baek, Hee Jin Chang, Hee Chul Park, Hee Cheol Kim, Eui Kyu Chie, Taek-Keun Nam, Hong Seok Jang
Purpose: A pooled analysis of multi-institutional trials was performed to analyze the effect of surgical timing on tumor response by comparing short course concurrent chemoradiotherapy (CCRT) with long course CCRT followed by delayed surgery in locally advanced rectal cancer. Materials and Methods: Three hundred patients with cT3-4N0-2 rectal adenocarcinoma were included. Long course patients from KROG 14-12 (n=150) were matched 1:1 to 150 short course patients from KROG 10-01 (NCT01129700) and KROG 11-02 (NCT01431599) according to stage, age, and other risk factors...
November 21, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29161796/-small-bowel-perforation-caused-by-press-through-package
#3
Jung Seok Kim, Jae Myung Cha, Min Seob Kwak, Jin Young Yoon, Jung Won Jeon, Hyun Phil Shin, Kwang Ro Joo, Joung Il Lee, Hye Young Kim
With an increased use of the press-through package (PTP) tablet, there has also been an increase in mis-swallowing cases, especially in elderly patients. We report a rare case of PTP-induced small bowel perforation and fistula formation with adjacent small bowel in a healthy elderly patient, who experienced persistent abdominal pain of unknown cause. A 62-year-old healthy man was admitted to our hospital with left abdominal pain that started one month ago. Neither abdominal tenderness nor rebound tenderness was present on physical examination...
November 25, 2017: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/29161794/feasibility-of-temporary-pancreatic-stenting-after-early-endoscopic-retrograde-cholangiopancreatography-in-patients-with-acute-biliary-pancreatitis
#4
Jun Kyu Lee, Dong Kee Jang, Hyun Woo Kang, Sang Hyub Lee
Background/Aims: To assess the safety and effectiveness of temporary pancreatic stenting after early endoscopic retrograde cholangiopancreatography (ERCP) in patients with acute biliary pancreatitis regardless of the severity or concomitant cholangitis. Methods: Temporary pancreatic stenting was performed in 79 patients with visualized pancreatic duct during ERCP. The outcomes of 64 patients with adequate pancreatic stenting (PS) and 15 patients with inadequate pancreatic stenting (no PS) were compared in this prospective, observational trial...
November 25, 2017: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/29161778/highly-efficient-destruction-of-squamous-carcinoma-cells-of-the-head-and-neck-by-photochemical-internalization-of-ranpirnase
#5
Nora Liebers, Tim Holland-Letz, Mona Welschof, Anders Høgset, Dirk Jäger, Michaela A E Arndt, Jürgen Krauss
Introduction: Photochemical Internalization is a novel drug delivery technology for cancer treatment based on the principle of Photodynamic Treatment. Using a photosensitizer that locates in endocytic vesicles membranes of tumor cells, Photochemical internalization enables cytosolic release of endocytosed antitumor agents in a site-specific manner. The purpose of the present in-vitro study was to explore whether Photochemical Internalization is able to enhance the efficacy of Ranpirnase, a cytotoxic amphibian ribonuclease, for eradication of squamous cell carcinoma of the head and neck...
November 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/29161775/the-influence-of-different-peptide-combinations-to-increase-the-immunogenicity-of-the-gonadotrophin-releasing-hormone-vaccine-for-prostate-cancer-treatment
#6
Franklin Fuentes Aguilar, Jesús Junco Barranco, Lesvia Calzada Aguilera, Eddy Bover Fuentes, Jose André Serradelo Leal, Eduardo Hernández López, Eulogio Pimentel Vázquez, Roberto Basulto Baker, Osvaldo Reyes Acosta, Hilda Garay Pérez, Gerardo Guillén Nieto
Purpose: Therapeutic vaccines, specifically the Gonadotrophin Releasing Hormone (GnRH) vaccine, are considered an additional therapeutic option for advanced stage prostate cancer. Our work showed amplification of the immune response when combining two peptides with and without the Very Small Size Proteoliposomes (VSSP). VSSP is a potent adjuvant for dendritic cells activation and Th1 differentiation. as enhanced immune response. Methods: The test was carried out in Copenhagen rats as animal model...
November 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/29161766/identification-of-alpha-gal-sensitivity-in-patients-with-a-diagnosis-of-idiopathic-anaphylaxis
#7
Melody C Carter, Karina N Ruiz-Esteves, Lisa Workman, Philip Lieberman, Thomas A E Platts-Mills, Dean D Metcalfe
IgE antibodies (Ab) specific to galactose-α-1,3-galactose (alpha-gal) are responsible for a delayed form of anaphylaxis that occurs 3 to 6 hours after red meat ingestion. In a unique prospective study of seventy participants referred with a diagnosis of idiopathic anaphylaxis (IA), six (9%) were found to have IgE to alpha-gal. Upon institution of a diet free of red meat, all patients had no further episodes of anaphylaxis. Two of these individuals had indolent systemic mastocytosis (ISM). Those with ISM had more severe clinical reactions but lower specific IgE to alpha-gal and higher serum tryptase levels, reflective of the mast cell burden...
November 21, 2017: Allergy
https://www.readbyqxmd.com/read/29161764/mechanism-of-doxorubicin-cardiotoxicity-evaluated-by-integrating-multiple-molecular-effects-into-a-biophysical-model
#8
M Fernandez-Chas, M J Curtis, S A Niederer
BACKGROUND AND PURPOSE: Doxorubicin (DOX) is an effective cancer therapeutic agent but causes therapy-limiting cardiotoxicity. The effects of DOX and its metabolite doxorubicinol (DOXL) on individual channels have been well characterised in isolation. However, it is unknown how the action and interaction of affected channels combine to generate the phenotypic cardiotoxic outcome. We sought to develop an in silico model that links drug effects on channels to action potential duration (APD) and intracellular Ca(2+) concentration in order to address this gap in knowledge...
November 21, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29161755/kv-1-channel-expression-and-vasomotor-function-in-human-coronary-resistance-arteries
#9
Yoshinori Nishijima, Ankush Korishettar, Dawid S Chabowski, Sheng Cao, Xiaodong Zheng, David D Gutterman, David X Zhang
OBJECTIVES: KV channels are important regulators of vascular tone, but the identity of specific KV channels involved and their regulation in disease remain less well understood. We determined the expression of KV 1 channel subunits and their role in cAMP-mediated dilation in coronary resistance arteries from subjects with and without coronary artery disease (CAD). METHODS: Human coronary arteries and arterioles (HCA) from non-CAD and CAD patients were assessed for mRNA and protein expression of KV 1 channel subunits with molecular techniques and for vasodilator response with isolated arterial myography...
November 21, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29161753/improving-the-efficacy-of-proteasome-inhibitors-in-the-treatment-of-renal-cell-carcinoma-by-combination-with-the-hiv-protease-inhibitors-lopinavir-or-nelfinavir
#10
Dominik Abt, Andrej Besse, Lenka Sedlarikova, Marianne Kraus, Juergen Bader, Tobias Silzle, Martina Vodinska, Ondrej Slaby, Hans-Peter Schmid, Daniel Stephan Engeler, Christoph Driessen, Lenka Besse
OBJECTIVES: To assess the potential of second-generation proteasome inhibition by carfilzomib and its combination with the HIV-protease inhibitors (HIV-PIs) lopinavir and nelfinavir in vitro for improved treatment of clear cell renal cell cancer (ccRCC). MATERIALS AND METHODS: Cytotoxicity, reactive oxygen species (ROS) production and unfolded protein response (UPR) activation of proteasome inhibitors, HIV-PIs and their combination was assessed in 3 cell lines and primary cells derived from 3 ccRCC tumors by MTS assay, flow cytometry, quantitative PCR and western blot, respectively...
November 21, 2017: BJU International
https://www.readbyqxmd.com/read/29161746/exercise-performed-concomitantly-with-particulate-matter-exposure-inhibits-lung-injury
#11
Adriano Silva-Renno, Guilherme Crisitanini Baldivia, Manoel C Oliveira-Junior, Maysa Alves Rodrigues Brandao-Rangel, Elias El-Mafarjeh, Marisa Dolhnikoff, Thaís Mauad, Jôse Mára Britto, Paulo Hilário Nascimento Saldiva, Luis Vicente Franco Oliveira, Ana P Ligeiro-Oliveira, Gustavo Silveira Graudenz, Rodolfo Paula Vieira
Air pollution is a growing problem worldwide, inducing and exacerbating several diseases. Among the several components of air pollutants, particulate matter (PM), especially thick (10-2.5 µm; PM 10) and thin (≤2.5 µm; PM 2.5), are breathable particles that easily can be deposited within the lungs, resulting in pulmonary and systemic inflammation. Although physical activity is strongly recommended, its effects when practiced in polluted environments are questionable. Therefore, the present study evaluated the pulmonary and systemic response of concomitant treadmill training with PM 2...
November 21, 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29161745/resting-autonomic-function-in-active-and-insufficiently-active-people-living-with-hiv
#12
Norberto Quiles, Carol Garber, Joseph Ciccolo
Autonomic dysfunction appears to be prevalent in people living with HIV/AIDS (PLWHA). However, there are limited data on the resting autonomic responses to exercise in active and insufficiently active PLWHA. We aimed to determine whether active PLWHA have better autonomic responses compared with insufficiently active PLWHA. Active PLWHA receiving anti-retroviral therapy (n=13) and insufficiently active PLWHA (n=10) were recruited. A 10-min recording of the supine electrocardiogram was taken. Resting heart rate variability was analyzed from this electrocardiogram...
November 21, 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29161706/endotoxin-effects-on-cardiac-and-renal-functions-and-cardiorenal-syndromes
#13
Grazia Maria Virzì, Anna Clementi, Alessandra Brocca, Claudio Ronco
Gram-negative sepsis is a major cause of morbidity and mortality in critical ill patients. Recent findings in molecular biology and in signaling pathways have enhanced our understanding of its pathogenesis and opened up opportunities of innovative therapeutic approaches. Endotoxin plays a pivotal role in the pathogenesis of multi-organ dysfunction in the setting of gram-negative sepsis. Indeed, heart and kidney impairments seem to be induced by the release of circulating pro-inflammatory and pro-apoptotic mediators triggered by endotoxin interaction with immune cells...
November 22, 2017: Blood Purification
https://www.readbyqxmd.com/read/29161701/yin-yang-1-dynamically-regulates-antiviral-innate-immune-responses-during-viral-infection
#14
Jie Zan, Hao Zhang, Ai-Ping Gu, Kai-Lun Zhong, Min-Yi Lu, Xiao-Xin Bai, Jin-Yang Zhang, Jun Cai
BACKGROUND/AIMS: Type I interferon (IFN-1) production and IFN-1 signaling play critical roles in the host antiviral innate immune responses. Although transcription factor Yin Yang 1 (YY1) has been reported to have a dual activator/repressor role during the regulation of interferon beta (IFN-β) promoter activity, the roles of YY1 in the regulation of upstream signaling pathways leading to IFN-1 induction and IFN-1 signaling during viral infection remain to be elucidated. METHODS: The roles of YY1 in IFN-1 production and IFN-1 signaling were investigated using immunoblotting, real-time PCR, small interfering RNA (siRNA)-mediated YY1 knockdown, YY1 overexpression by transient transfection, and co-immunoprecipitation, using mouse cells...
November 20, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29161699/patterns-of-detection-of-fetal-posterior-fossa-anomalies-analysis-of-81-cases-in-the-second-half-of-gestation
#15
Stéphanie Friszer, Ferdinand Dhombres, Eléonore Blondiaux, Marie-Laure Moutard, Catherine Garel, Jean-Marie Jouannic
OBJECTIVE: To establish which characteristics of fetal ultrasound screening lead to the diagnosis of posterior fossa (PF) anomalies. METHODS: A total of 81 fetuses with PF anomalies diagnosed after dedicated neuroimaging between July 1, 2007, and January 1, 2013, were included. The ultrasound characteristics of the fetal cerebellum categorized according to an anatomical approach to the PF, associated fetal anomalies, gestational age at diagnosis, and the potential benefits from systematic measurement of the transverse cerebellar diameter (TCD) were analyzed...
November 21, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/29161696/the-protein-expression-level-of-a-heterogeneous-gene-inserted-in-lipi-1-of-the-listeria-ivanovii-genome-relies-on-its-insertion-orientation
#16
Sijing Liu, Mingjuan Jiang, Lin Su, Tian Tang, Xiang Zhang, Yongyu Li, Qikang Pu, Chenyan Ren, Chuan Wang
Due to its capability to multiply in either phagocytic or nonphagocytic cells, and to subsequently elicit a robust cellular immune response, Listeria ivanovii (LI) is thought to be feasible for developing bacteria-based live attenuated vaccines. We previously generated several recombinant LI strains expressing Mycobacterium tuberculosis antigens. Since the expression level of heterogeneous protein was sometimes very low, we attempted to elucidate the principle of heterogeneous protein expression in such recombinant LI strains...
November 22, 2017: Journal of Molecular Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29161690/catechins-blunt-the-effects-of-oxldl-and-its-primary-metabolite-phosphatidylcholine-hydroperoxide-on-endothelial-dysfunction-through-inhibition-of-oxidative-stress-and-restoration-of-enos-in-rats
#17
Hao-Hsiang Chang, Chen-Yen Chien, Kuo-Hsin Chen, Shih-Chung Huang, Chiang-Ting Chien
BACKGROUND/AIMS: We explored the effects of catechins (decaffeinated green tea extracts containing (-)-epicatechin, (-)-epigallocatechin, (-)-epicatechin gallate and (-)-epigallocatechin gallate) on atherosclerosis risk factors, oxidized low-density lipoprotein (oxLDL) and its primary metabolite, phosphatidylcholine hydroperoxide (PCOOH) induced oxidative injury in cultured endothelial cell line and rats. METHODS: We used endothelial cell line and male Wistar rats to determine the effect of catechins on oxLDL or PCOOH induced oxidative injury including apoptosis, H2O2 level, vascular responses and urinary 8-isoprostane and nitrite/nitrate concentration...
November 22, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29161677/nanotechnology-based-recent-approaches-for-sensing-and-remediation-of-pesticides
#18
REVIEW
Deepak Rawtani, Nitasha Khatri, Sanjiv Tyagi, Gaurav Pandey
Pesticides are meant to control and destroy the pests and weeds. They are classified into different categories on the basis their origin and type of pest they target. Chemical pesticides such as insecticides, herbicides and fungicides are commonly used in agricultural fields. However, the excessive use of these agrochemicals have adverse effects on environment such as reduced population of insect pollinators, threat to endangered species and habitat of birds. Upon consumption; chemical pesticides also cause various health issues such as skin, eye and nervous system related problems and cancer upon prolonged exposure...
November 18, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/29161674/deep-brain-stimulation-of-the-subcallosal-cingulate-gyrus-in-patients-with-treatment-resistant-depression-a-double-blinded-randomized-controlled-study-and-long-term-follow-up-in-eight-patients
#19
Angela Merkl, Sabine Aust, Gerd-Helge Schneider, Veerle Visser-Vandewalle, Andreas Horn, Andrea A Kühn, Jens Kuhn, Malek Bajbouj
BACKGROUND: Deep brain stimulation (DBS) of the subcallosal cingulate gyrus (SCG) is an experimental approach in treatment-resistant depression (TRD). Short-term results of efficacy in DBS are incongruent and studies investigating long-term effects are warranted. METHODS: We assessed efficacy of SCG-DBS in eight patients randomized into a delayed-onset group (sham-DBS four weeks) and a non-delayed-onset group. The primary outcome measure was improvement on the Hamilton Depression Rating-Scale (HAMD-24-item-version)...
November 8, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29161670/construction-of-plasmonic-ag-modified-phosphorous-doped-ultrathin-g-c3n4-nanosheets-bivo4-photocatalyst-with-enhanced-visible-near-infrared-response-ability-for-ciprofloxacin-degradation
#20
Yaocheng Deng, Lin Tang, Chengyang Feng, Guangming Zeng, Jiajia Wang, Yaoyu Zhou, Yani Liu, Bo Peng, Haopeng Feng
To realize the full utilization of solar energy, the design of highly efficient photocatalyst with improved visible-near-infrared photocatalysis performance has attracted great attentions for environment pollutant removal. In this work, we rationally employed the surface plasmon resonance effect of metallic Ag in the phosphorus doped ultrathin g-C3N4 nanosheets (PCNS) and BiVO4 composites to construct a ternary Ag@PCNS/BiVO4 photocatalyst. It was applied for the photodegradation of ciprofloxacin (CIP), exhibiting 92...
November 15, 2017: Journal of Hazardous Materials
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