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Smart biomaterial

Zhijun Shi, Xing Gao, Muhammad Wajid Ullah, Sixiang Li, Qun Wang, Guang Yang
Hydrogels prepared from natural polymers have received immense considerations over the past decade due to their safe nature, biocompatibility, hydrophilic properties, and biodegradable nature. More recently, when treated with electroactive materials, these hydrogels were endowed with high electrical conductivity, electrochemical redox properties, and electromechanical properties; consequently, forming a smart hydrogel. The biological properties of these smart hydrogels, classified as electroconductive hydrogels, can be combined with electronics...
September 30, 2016: Biomaterials
Cui Tan, Xiaoxu Zhang, Qing Li
Two major problems with magnesium (Mg) alloy biomaterials are the poor corrosion resistance and infection associated with implantation. In this study, a novel calcium phosphate (CaP)/tetracycline (TC) composite coating for Mg implants that can both improve the corrosion resistance of Mg and release a drug in a durable way is reported. Scanning electron microscope (SEM) images showed that TC additives make the CaP coating more compact and uniform. Electrochemical tests indicated CaP/TC coatings can provide excellent corrosion protection for Mg alloy substrates...
October 8, 2016: Biomedizinische Technik. Biomedical Engineering
Hirak K Patra, Yashpal Sharma, Mohammad Mirazul Islam, Mohammad Javad Jafari, N Arul Murugan, Hisatoshi Kobayashi, Anthony P F Turner, Ashutosh Tiwari
To cope with the rapid evolution of the tissue engineering field, it is now essential to incorporate the use of on-site responsive scaffolds. Therefore, it is of utmost importance to find new 'Intelligent' biomaterials that can respond to the physicochemical changes in the microenvironment. In this present report, we have developed biocompatible stimuli responsive polyaniline-multiwalled carbon nanotube/poly(N-isopropylacrylamide), (PANI-MWCNT/PNIPAm) composite nanofiber networks and demonstrated the physiological temperature coordinated cell grafting phenomenon on its surface...
October 6, 2016: Nanoscale
Christopher D Jones, Jonathan W Steed
Advances in the field of supramolecular chemistry have made it possible, in many situations, to reliably engineer soft materials to address a specific technological problem. Particularly exciting are "smart" gels that undergo reversible physical changes on exposure to remote, non-invasive environmental stimuli. This review explores the development of gels which are transformed by heat, light and ultrasound, as well as other mechanical inputs, applied voltages and magnetic fields. Focusing on small-molecule gelators, but with reference to organic polymers and metal-organic systems, we examine how the structures of gelator assemblies influence the physical and chemical mechanisms leading to thermo-, photo- and mechano-switchable behaviour...
September 20, 2016: Chemical Society Reviews
May Griffith, Mohammad M Islam, Joel Edin, Georgia Papapavlou, Oleksiy Buznyk, Hirak K Patra
Biomaterials are now being used or evaluated clinically as implants to supplement the severe shortage of available human donor organs. To date, however, such implants have mainly been developed as scaffolds to promote the regeneration of failing organs due to old age or congenital malformations. In the real world, however, infection or immunological issues often compromise patients. For example, bacterial and viral infections can result in uncontrolled immunopathological damage and lead to organ failure. Hence, there is a need for biomaterials and implants that not only promote regeneration but also address issues that are specific to compromised patients, such as infection and inflammation...
2016: Frontiers in Bioengineering and Biotechnology
Hee-Won Kim, Kisuk Yang, Woo-Jin Jeong, Sung-Ju Choi, Jong Seung Lee, Ann-Na Cho, Gyeong-Eon Chang, Eunji Cheong, Seung-Woo Cho, Yong-Beom Lim
Stimuli-responsive hybrid materials that combine the dynamic nature self-assembled organic nanostructures, unique photophysical properties of inorganic materials, and molecular recognition capability of biopolymers can provide sophisticated nanoarchitectures with unprecedented functions. In this report, infrared (IR)-responsive self-assembled peptide-carbon nanotube (CNT) hybrids that enable the spatiotemporal control of bioactive ligand multivalency and subsequent human neural stem cell (hNSC) differentiation are reported...
October 12, 2016: ACS Applied Materials & Interfaces
M Salimi Bani, H Asgharzadeh Shirazi, M R Ayatollahi, Alireza Asnafi
Based on radial functionally graded biomaterials and inspired by the geometry of a real aorta blood vessel, a new model was proposed to fabricate the artificial blood vessels. A finite element analyzer is employed to reach the optimal and proper material properties while earlier, it was validated by two famous theories, i.e., the first shear deformation and the plane elasticity. First, the geometry of a real ascending aorta part was simulated and then solved under the axially varying blood pressure and other real and actual conditions...
September 15, 2016: Medical & Biological Engineering & Computing
Antonio Paciello, Giuseppe Amalfitano, Alessandro Garziano, Francesco Urciuolo, Paolo A Netti
In this study, a novel micrometric biomaterial acting as a cyclic oxygen releasing system is designed. Human hemoglobin (Hb) is conjugated to the surface of gelatin microspheres (GM) to produce gelatin hemoglobin oxygen depot (G-HbOD). G-HbOD is obtained by means of two different conjugation strategies. The degree of conjugation of GM surfaces in terms of free amino groups by using HPLC is first evaluated. By following the strategy A (G-HbOD_A), Hb is conjugated to GM by means of the formation of a polyurethane linker...
September 5, 2016: Advanced Healthcare Materials
Adérito J R Amaral, George Pasparakis
Cell surface engineering has emerged as a powerful approach to forming cell aggregates/spheroids and cell-biomaterial ensembles with significant uses in tissue engineering and cell therapeutics. Herein, we demonstrate that cell membrane remodeling with a thermoresponsive boronic acid copolymer induces the rapid formation of spheroids using either cancer or cardiac cell lines under conventional cell culture conditions at minute concentrations. It is shown that the formation of well-defined spheroids is accelerated by at least 24 h compared to non-polymer-treated controls, and, more importantly, the polymer allows for fine control of the aggregation kinetics owing to its stimulus response to temperature and glucose content...
September 7, 2016: ACS Applied Materials & Interfaces
Liyang Shi, Yuanyuan Han, Jöns Hilborn, Dmitri Ossipov
We report a strategy to generate a self-healing and pH responsive hydrogel network between drug-loaded nanoparticles and natural polysaccharides via magnesium-bisphosphonate ligand interactions. The injectable drug depot disassembles in a tumor-specific environment, providing localized uptake of the nanoparticles, which is highly appreciated in drug delivery applications and manufacturing of drug-loaded biomaterials using a syringe-based deposition technique.
September 25, 2016: Chemical Communications: Chem Comm
Muhammad Jbara, Shay Laps, Suman Kumar Maity, Ashraf Brik
The design and synthesis of biomolecules that are responsive to external stimuli is of great interest in various research areas, such as in the preparation of smart biomaterial and chemical biology. Polypeptide backbone disassembly as a response to a particular stimulus is of interest, as it leads to a complete loss of the protein tertiary structure and, as a result, to a loss of function. In this study, a strategy based on palladium-assisted efficient cleavage of backbone thiazolidine linkage in peptides and proteins was developed...
October 10, 2016: Chemistry: a European Journal
Fernando Luis Esteban Florez, Rochelle Denise Hiers, Kristin Smart, Jens Kreth, Fengxia Qi, Justin Merritt, Sharukh Soli Khajotia
OBJECTIVE: The release of unpolymerized monomers and by-products of resin composites influences biofilm growth and confounds the measurement of metabolic activity. Current assays to measure biofilm viability have critical limitations and are typically not performed on relevant substrates. The objective of the present study was to determine the utility of firefly luciferase assay for quantification of the viability of intact biofilms on a resin composite substrate, and correlate the results with a standard method (viable colony counts)...
October 2016: Dental Materials: Official Publication of the Academy of Dental Materials
Uwe Freudenberg, Yingkai Liang, Kristi L Kiick, Carsten Werner
Glycosaminoglycans (GAGs) govern important functional characteristics of the extracellular matrix (ECM) in living tissues. Incorporation of GAGs into biomaterials opens up new routes for the presentation of signaling molecules, providing control over development, homeostasis, inflammation, and tumor formation and progression. Recent approaches to GAG-based materials are reviewed, highlighting the formation of modular, tunable biohybrid hydrogels by covalent and non-covalent conjugation schemes, including both theory-driven design concepts and advanced processing technologies...
July 27, 2016: Advanced Materials
Hong-Wei An, Sheng-Lin Qiao, Li-Li Li, Chao Yang, Yao-Xin Lin, Yi Wang, Zeng-Ying Qiao, Lei Wang, Hao Wang
Bioinspired design concept has been recognized as one of the most promising strategies for discovering new biomaterials. However, smart biomaterials that are of growing interests in biomedical field need biological processability to meet their emergent applications in vivo. Herein, a new bio-orthogonally deciphered approach has been demonstrated for modulating optical properties of nanomaterials in living systems. The self-assembled nanoemitters based on cyanine-pyrene molecule 1 with inert optical property are designed and prepared...
August 3, 2016: ACS Applied Materials & Interfaces
Yun Xiao, Samad Ahadian, Milica Radisic
Progress in biomaterials science and engineering and increasing knowledge in cell biology have enabled us to develop functional biomaterials providing appropriate biochemical and biophysical cues for tissue regeneration applications. Tissue regeneration is particularly important to treat chronic wounds of people with diabetes. Understanding and controlling the cellular microenvironment of the wound tissue are important to improve the wound healing process. Here, we review different biochemical (e.g., growth factors, peptides, DNA, and RNA) and biophysical (e...
July 13, 2016: Tissue Engineering. Part B, Reviews
Francesco Baino, Sonia Fiorilli, Chiara Vitale-Brovarone
UNLABELLED: Bioactive glasses have been traditionally used in the clinical practice to fill and restore osseous defects due to their unique ability to bond to host bone and stimulate new bone growth. In the last decade, a new set of bioactive glasses characterized by a highly ordered mesoporous texture has been developed and studied as a smart platform for the controlled release of biomolecules, in situ therapy and regenerative applications. This review points out the great potential carried by hierarchical bioactive glass scaffolds that exhibit pore scales from the meso- to the macro-range, and their impact in the broad field of tissue engineering, including the emerging applications in contact with soft tissues and diagnostics...
September 15, 2016: Acta Biomaterialia
Cuixia Chen, Yu Zhang, Rui Fei, Changhai Cao, Meng Wang, Jingxin Wang, Jingkun Bai, Henry Cox, Thomas Waigh, Jian R Lu, Hai Xu
The self-assembly of short peptides is a promising route to the creation of smart biomaterials. To combine peptide self-assembly with enzymatic catalysis, we design an amphiphilic short peptide I3QGK that can self-assemble into long nanoribbons in aqueous solution. Upon addition of transglutaminase (TGase), the peptide solution undergoes a distinct sol-gel transition to form a rigid hydrogel, which shows strong shear-thinning and immediate recovery properties. Transmission electron microscopy (TEM) and atomic force microscopy (AFM) measurements indicate the occurrence of considerable nanofibers in addition to the original nanoribbons...
July 20, 2016: ACS Applied Materials & Interfaces
Merve Erginer, Ayca Akcay, Binnaz Coskunkan, Tunc Morova, Deniz Rende, Seyda Bucak, Nihat Baysal, Rahmi Ozisik, Mehmet S Eroglu, Mehmet Agirbasli, Ebru Toksoy Oner
Chemical derivatives of levan from Halomonas smyrnensis AAD6(T) with low, medium and high levels of sulfation were synthesized and characterized by FTIR and 2D-NMR. Sulfated levan samples were found to exhibit anticoagulation activity via the intrinsic pathway like heparin in a dose-dependent manner. Exceptionally high heparin equivalent activity of levan sulfate was shown to proceed via thrombin inhibition where decreased Factor Xa activity with increasing concentration was observed in antithrombin tests and above a certain concentration, levan sulfate showed a better inhibitor activity than heparin...
September 20, 2016: Carbohydrate Polymers
Yan-Fang Li, Peter Slemming-Adamsen, Jing Wang, Jie Song, Xueqin Wang, Ying Yu, Mingdong Dong, Chunying Chen, Flemming Besenbacher, Menglin Chen
Smart materials for on-demand delivery of therapeutically active agents are challenging in pharmaceutical and biomaterials science. In the present study, we report hybrid nanofibres capable of being reversibly controlled to pulsatile deliver both therapeutic drugs and cells on-demand of near-infrared (NIR) light. The nanofibres, fabricated by co-electrospinning of poly (N-isopropylacrylamide), silica-coated gold nanorods and polyhedral oligomeric silsesquinoxanes have, for the first time, demonstrated rapid, reversible large-volume changes of 83% on-demand with NIR stimulation, with retained nanofibrous morphology...
May 31, 2016: Journal of Tissue Engineering and Regenerative Medicine
Kin-Ya Tomizaki, Atsushi Tanaka, Hiroki Shimada, Koki Nishizawa, Tsubasa Wada, Takahito Imai
There is increasing interest in designing smart biomaterials by employing the self-assembly characteristics of synthetic peptides. The use of amyloid-like fibrils is one approach to nanometer- and micrometer-sized supramolecular structures. However, it is generally difficult to predict and/or analyze peptide conformations in nanostructures generated by the self-assembly of β-sheet-forming peptides such as amyloid-β peptide because each peptide experiences a slightly different environment. Therefore, a methodology for rationally designing peptide-based smart materials is required...
June 1, 2016: Bioorganic & Medicinal Chemistry Letters
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