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Smart biomaterial

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https://www.readbyqxmd.com/read/29130888/co-delivery-of-cisplatin-and-cjm-126-via-photothermal-conversion-nanoparticles-for-enhanced-synergistic-antitumor-efficacy
#1
Chaoqun You, Hongshuai Wu, Mingxin Wang, Zhiguo Gao, Xiangyang Zhang, Baiwang Sun
Polymeric biomaterials that can be smartly disassembled through the cleavage of the covalent bonds in a controllable method upon an environmental stimuli such as pH change, redox, special enzymes, temperature, ultrasound as well as light irradiation but otherwise are stable under physiological condition has attracted great attention in past decades. In our study, a novel NIR-responsive targeted binary-drug loaded nanoparticles encapsulating ICG dye was prepared as a new co-delivery and combined therapy vehicle...
November 13, 2017: Nanotechnology
https://www.readbyqxmd.com/read/29049304/investigation-of-surface-topography-and-stiffness-on-adhesion-and-neurites-extension-of-pc12-cells-on-crosslinked-silica-aerogel-substrates
#2
Kyle J Lynch, Omar Skalli, Firouzeh Sabri
Fundamental understanding and characterization of neural response to substrate topography is essential in the development of next generation biomaterials for nerve repair. Aerogels are a new class of materials with great potential as a biomaterial. In this work, we examine the extension of neurites by PC12 cells plated on matrigel-coated and collagen-coated mesoporous aerogel surfaces. We have successfully established the methodology for adhesion and growth of PC12 cells on polyurea crosslinked silica aerogels...
2017: PloS One
https://www.readbyqxmd.com/read/29031897/smart-electrical-bi-layers-lipopeptides-novel-peptidic-chains-like-zigzag-map-esterified-with-phospho-glyceride-as-mono-layer-moieties-capable-in-forming-a-meso-sphere-envelop-with-scaffold-ability-to-cellular-impurities
#3
REVIEW
Sami Saadi, Nazamid Saari, Abdulkarim Sabo Mohammed, Hasanah Mohd Ghazali, Farooq Anwar
Cell impurities are an emerging nucleating molecular barriers having the capability in disordering the metabolic chain reactions of proteolysis, glycolysis and lipolysis. Their massive effects induced by copolymer crystal growth in compaction with metal and mineral transients are extended as well as in damaging DNA and mRNA structure motif and other molecular assembly e.g. histones structure unites. Their polycrystalline packing modes, polydispersity and their tendency to surface and interface adhesion prompted us in structuring scaffold biomaterials enriched with biopeptides, layered by phospho-glycerides ester-forms...
October 11, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28992510/three-dimensional-piezoelectric-fibrous-scaffolds-selectively-promote-mesenchymal-stem-cell-differentiation
#4
Sita M Damaraju, Yueyang Shen, Ezinwa Elele, Boris Khusid, Ahmad Eshghinejad, Jiangyu Li, Michael Jaffe, Treena Livingston Arinzeh
The discovery of electric fields in biological tissues has led to efforts in developing technologies utilizing electrical stimulation for therapeutic applications. Native tissues, such as cartilage and bone, exhibit piezoelectric behavior, wherein electrical activity can be generated due to mechanical deformation. Yet, the use of piezoelectric materials have largely been unexplored as a potential strategy in tissue engineering, wherein a piezoelectric biomaterial acts as a scaffold to promote cell behavior and the formation of large tissues...
September 19, 2017: Biomaterials
https://www.readbyqxmd.com/read/28975171/injectable-nanoengineered-stimuli-responsive-hydrogels-for-on-demand-and-localized-therapeutic-delivery
#5
Nima A Jalili, Manish K Jaiswal, Charles W Peak, Lauren M Cross, Akhilesh K Gaharwar
"Smart" hydrogels are an emerging class of biomaterials that respond to external stimuli and have been investigated for a range of biomedical applications, including therapeutic delivery and regenerative engineering. Stimuli-responsive nanogels constructed of thermoresponsive polymers such as poly(N-isopropylacrylamide-co-acrylamide) (poly(NIPAM-co-AM)) and magnetic nanoparticles (MNPs) have been developed as "smart carriers" for on-demand delivery of therapeutic biomolecules via magneto-thermal activation...
October 19, 2017: Nanoscale
https://www.readbyqxmd.com/read/28960765/new-hydroxyapatite-nanophases-with-enhanced-osteogenic-and-antibacterial-activity
#6
A Ballardini, M Montesi, S Panseri, A Vandini, P G Balboni, A Tampieri, S Sprio
The present work describes the synthesis and characterization of new apatite phases co-doped with gallium, magnesium and carbonate, exhibiting osteogenic and antibacterial ability. The apatites are synthesized at low temperature to retain nanocrystallinity and controlled doping with the various bioactive foreign ions, as assessed by physico-chemical and crystallographic analyses, reporting the achievement of single phases with reduced crystal ordering. The analysis of single and multi-doped apatites reports to different mechanisms acting in the incorporation of gallium and magnesium ions in the apatite structure...
September 29, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28927933/azopolymer-photopatterning-for-directional-control-of-angiogenesis
#7
Chiara Fedele, Maria De Gregorio, Paolo A Netti, Silvia Cavalli, Chiara Attanasio
Understanding cellular behavior in response to microenvironmental stimuli is central to tissue engineering. An increasing number of reports emphasize the high sensitivity of cells to the physical characteristics of the surrounding milieu and in particular, topographical cues. In this work, we investigated the influence of dynamic topographic signal presentation on sprout formation and the possibility to obtain a space-time control over sprouting directionality without growth factors, in order to investigate the contribution of just topography in the angiogenic process...
November 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28841771/introduction-of-nature-s-complexity-in-engineered-blood-compatible-biomaterials
#8
REVIEW
Bastiaan D Ippel, Patricia Y W Dankers
Biomaterials with excellent blood-compatibility are needed for applications in vascular replacement therapies, such as vascular grafts, heart valves and stents, and in extracorporeal devices such as hemodialysis machines and blood-storage bags. The modification of materials that are being used for blood-contacting devices has advanced from passive surface modifications to the design of more complex, smart biomaterials that respond to relevant stimuli from blood to counteract coagulation. Logically, the main source of inspiration for the design of new biomaterials has been the endogenous endothelium...
August 25, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28821114/preparation-and-characterization-of-a-composite-biomaterial-including-starch-micro-nano-particles-loaded-chitosan-gel
#9
Dorsa Dehghan Baniani, Reza Bagheri, Atefeh Solouk
Thermosensitive Chitosan hydrogels which can be injected into defects with minimally invasive approach were prepared. Also starch micro/nano particles were synthesized via water-in-oil (W/O) miniemulsion technique. The starch particles were incorporated into the chitosan hydrogel to prepare injectable thermosensitive hydrogel composites. Tube inverting method, compression tests, swelling studies, XRD, SEM, OM, DLS, UV-vis spectroscopy were used for investigations. Results revealed that increasing crosslinker and surfactant contents and stirring rate leads to particle size reduction...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28782856/an-on-site-transformation-strategy-for-treatment-of-bacterial-infection
#10
Guo-Bin Qi, Di Zhang, Fu-Hua Liu, Zeng-Ying Qiao, Hao Wang
To date, numerous nanosystems have been developed as antibiotic replacements for bacterial infection treatment. However, these advanced systems are limited owing to their nontargeting accumulation and the consequent side effects. Herein, transformable polymer-peptide biomaterials have been developed that enable specific accumulation in the infectious site and long-term retention, resulting in enhanced binding capability and killing efficacy toward bacteria. The polymer-peptide conjugates are composed of a chitosan backbone and two functional peptides, i...
September 2017: Advanced Materials
https://www.readbyqxmd.com/read/28776612/overcoming-t-gondii-infection-and-intracellular-protein-nanocapsules-as-biomaterials-for-ultrasonically-controlled-drug-release
#11
REVIEW
M S Aw, L Paniwnyk
One of the pivotal matters of concern in intracellular drug delivery is the preparation of biomaterials containing drugs that are compatible with the host target. Nanocapsules for oral delivery are found to be suitable candidates for targeting Toxoplasma gondii (T. gondii), a maneuvering and smart protozoic parasite found across Europe and America that causes a subtle but deadly infection. To overcome this disease, there is much potential of integrating protein-based cells into bioinspired nanocompartments such as via biodegradable cross-linked disulfide polyelectrolyte nanoparticles...
September 26, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28774114/fc-binding-ligands-of-immunoglobulin-g-an-overview-of-high-affinity-proteins-and-peptides
#12
REVIEW
Weonu Choe, Trishaladevi A Durgannavar, Sang J Chung
The rapidly increasing application of antibodies has inspired the development of several novel methods to isolate and target antibodies using smart biomaterials that mimic the binding of Fc-receptors to antibodies. The Fc-binding domain of antibodies is the primary binding site for e.g., effector proteins and secondary antibodies, whereas antigens bind to the Fab region. Protein A, G, and L, surface proteins expressed by pathogenic bacteria, are well known to bind immunoglobulin and have been widely exploited in antibody purification strategies...
December 8, 2016: Materials
https://www.readbyqxmd.com/read/28711155/manufacturing-cell-therapies-using-engineered-biomaterials
#13
REVIEW
Amr A Abdeen, Krishanu Saha
Emerging manufacturing processes to generate regenerative advanced therapies can involve extensive genomic and/or epigenomic manipulation of autologous or allogeneic cells. These cell engineering processes need to be carefully controlled and standardized to maximize safety and efficacy in clinical trials. Engineered biomaterials with smart and tunable properties offer an intriguing tool to provide or deliver cues to retain stemness, direct differentiation, promote reprogramming, manipulate the genome, or select functional phenotypes...
October 2017: Trends in Biotechnology
https://www.readbyqxmd.com/read/28647792/regeneration-of-hyaline-cartilage-promoted-by-xenogeneic-mesenchymal-stromal-cells-embedded-within-elastin-like-recombinamer-based-bioactive-hydrogels
#14
David Pescador, Arturo Ibáñez-Fonseca, Fermín Sánchez-Guijo, Jesús G Briñón, Francisco Javier Arias, Sandra Muntión, Cristina Hernández, Alessandra Girotti, Matilde Alonso, María Consuelo Del Cañizo, José Carlos Rodríguez-Cabello, Juan Francisco Blanco
Over the last decades, novel therapeutic tools for osteochondral regeneration have arisen from the combination of mesenchymal stromal cells (MSCs) and highly specialized smart biomaterials, such as hydrogel-forming elastin-like recombinamers (ELRs), which could serve as cell-carriers. Herein, we evaluate the delivery of xenogeneic human MSCs (hMSCs) within an injectable ELR-based hydrogel carrier for osteochondral regeneration in rabbits. First, a critical-size osteochondral defect was created in the femora of the animals and subsequently filled with the ELR-based hydrogel alone or with embedded hMSCs...
August 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28637399/biomineralized-recombinant-collagen-based-scaffold-mimicking-native-bone-enhances-mesenchymal-stem-cell-interaction-and-differentiation
#15
Gloria Belén Ramirez-Rodríguez, Monica Montesi, Silvia Panseri, Simone Sprio, Anna Tampieri, Monica Sandri
The need of synthetic bone grafts that recreate from macro to nanoscale level the biochemical and biophysical cues of bone extracellular matrix (ECM) has been a major driving force for the development of new generation of biomaterials. In this study, synthetic bone substitutes have been synthesized via biomimetic mineralization of a recombinant collagen type I derived peptide (RCP), enriched in tri-amino acid sequence arginine-glycine-aspartate (RGD). 3D isotropic porous scaffolds of three different compositions are developed by freeze-drying: non-mineralized (RCP, as a control), mineralized (Ap/RCP) and mineralized scaffolds in presence of magnesium (MgAp/RCP) that closely imitate bone composition...
June 22, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28608630/precisely-tailored-dna-nanostructures-and-their-theranostic-applications
#16
REVIEW
Bing Zhu, Lihua Wang, Jiang Li, Chunhai Fan
A critical challenge in nanotechnology is the limited precision and controllability of the structural parameters, which brings about concerns in uniformity, reproducibility and performance. Self-assembled DNA nanostructures, as a newly emerged type of nano-biomaterials, possess low-nanometer precision, excellent programmability and addressability. They can precisely arrange various molecules and materials to form spatially ordered complex, resulting in unambiguous physical or chemical properties. Because of these, DNA nanostructures have shown great promise in numerous biomedical theranostic applications...
June 13, 2017: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/28578565/conditional-network-assembly-and-targeted-protein-retention-via-environmentally-responsive-engineered-%C3%AE-roll-peptides
#17
Beyza Bulutoglu, Sarah J Yang, Scott Banta
Stimulus-responsive biomaterials have applications in many areas of biotechnology, such as tissue engineering, drug delivery, and bioelectrocatalysis. The intrinsically disordered repeat-in-toxin (RTX) domain is a conformationally dynamic peptide that gains β-roll secondary structure when bound to calcium ions. A smart hydrogel platform was constructed by genetically fusing two rationally designed mutant RTX domains: first, a mutant peptide with hydrophobic interfaces capable of calcium-dependent network assembly, and second, another mutant that conditionally binds the model target protein lysozyme...
June 15, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28576030/sustainable-and-smart-keratin-hydrogel-with-ph-sensitive-swelling-and-enhanced-mechanical-properties
#18
María Luz Peralta Ramos, Joaquín Antonio González, Lucas Fabian, Claudio Javier Pérez, María Emilia Villanueva, Guillermo Javier Copello
Protein based hydrogels are a very interesting type of biomaterials with many probed strengths related to their source and chemical structure. Biocompatibility and biodegradability are accompanied by affordability when it comes to low cost sources. The main keratin source is agroindustrial waste, such as feathers, horns, hooves, hair and wool. Thus, the main cost of keratin hydrogels derives from their processing. Here is presented a new strategy for the obtaining of a keratin hydrogel with enhanced mechanical properties using low cost reagents...
September 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28574092/a-highly-controllable-protein-self-assembly-system-with-morphological-versatility-induced-by-reengineered-host-guest-interactions
#19
Xiumei Li, Yushi Bai, Zupeng Huang, Chengye Si, Zeyuan Dong, Quan Luo, Junqiu Liu
Manipulating proteins to self-assemble into highly ordered nanostructures not only provides insights into the natural protein assembly process but also allows access to advanced biomaterials. Host-guest interactions have been widely used in the construction of artificial protein assemblies in recent years. CB[8] can selectively associate with two tripeptide Phe-Gly-Gly (FGG) tags with an extraordinarily high binding affinity (Kter = 1.5 × 10(11) M(-2)). However, the FGG tags utilized before are all fixed to the N-termini via genetic fusion; this spatial limitation greatly confined the availability of the CB[8]/FGG pair in the construction of more sophisticated protein nanostructures...
June 2, 2017: Nanoscale
https://www.readbyqxmd.com/read/28558979/biocompatibility-of-hydrogel-based-scaffolds-for-tissue-engineering-applications
#20
REVIEW
Sheva Naahidi, Mousa Jafari, Megan Logan, Yujie Wang, Yongfang Yuan, Hojae Bae, Brian Dixon, P Chen
Recently, understanding of the extracellular matrix (ECM) has expanded rapidly due to the accessibility of cellular and molecular techniques and the growing potential and value for hydrogels in tissue engineering. The fabrication of hydrogel-based cellular scaffolds for the generation of bioengineered tissues has been based on knowledge of the composition and structure of ECM. Attempts at recreating ECM have used either naturally-derived ECM components or synthetic polymers with structural integrity derived from hydrogels...
May 27, 2017: Biotechnology Advances
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