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https://www.readbyqxmd.com/read/28532072/new-bioactive-bone-like-microspheres-with-intrinsic-magnetic-properties-obtained-by-bio-inspired-mineralisation-process
#1
Tatiana Marisa Fernandes Patrício, Silvia Panseri, Monica Sandri, Anna Tampieri, Simone Sprio
A bio-inspired mineralisation process was investigated and applied to develop novel hybrid magnetic materials by heterogeneous nucleation of Fe(2+)/Fe(3+)-doped hydroxyapatite nanocrystals onto a biopolymeric matrix made of a Type I collagen-based recombinant peptide (RCP). The effect of the synthesis temperature on the phase composition, crystallinity and magnetic properties of the nucleated inorganic phase was studied. The as-obtained magnetic materials were then engineered, by using a water-in-oil emulsification process, into hybrid magnetic microspheres, which were stabilized by de-hydrothermal treatment yielding cross-linking of the macromolecular matrix...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28494738/smart-and-controllable-raav-gene-delivery-carriers-in-progenitor-cells-for-human-musculoskeletal-regenerative-medicine-with-a-focus-on-the-articular-cartilage
#2
Ana Rey-Rico, Magali Cucchiarini
Cell therapy using mesenchymal stem cells (MSCs) is a powerful tool for the treatment of various diseases and injuries. Still, important limitations including the large amounts of cells required for application in vivo and the age-related decline in lifespan, proliferation, and potency may hinder the use of MSCs in patients. In this regard, gene therapy may offer strong approaches to optimize the use of MSCs for regenerative medicine. Diverse nonviral and viral gene vehicles have been manipulated to genetically modify MSCs, among which the highly effective and relatively safe recombinant adeno-associated viral (rAAV) vectors that emerged as the preferred gene delivery system to treat human disorders...
May 10, 2017: Current Gene Therapy
https://www.readbyqxmd.com/read/28475310/novel-light-responsive-biocompatible-hydrogels-produced-by-initiated-chemical-vapor-deposition
#3
Katrin Unger, Paul Salzmann, Cecilia Masciullo, Marco Cecchini, Georg Koller, Anna Maria Coclite
A novel multiresponsive hydrogel has been synthesized by initiated chemical vapor deposition (iCVD). Hydrogels are known for their dynamic swelling response to aqueous environments. A chemical functionalization of the hydrogel surface was performed to add other stimuli-responsive functionalities and obtain a smart material that responds to two stimuli: light irradiation and exposure to aqueous environment. Modifying the hydrogel surface with solution-based methods is often problematic because of the damages caused by the permeation of solvents in the hydrogel...
May 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28420078/natural-phenol-polymers-recent-advances-in-food-and-health-applications
#4
REVIEW
Lucia Panzella, Alessandra Napolitano
Natural phenol polymers are widely represented in nature and include a variety of classes including tannins and lignins as the most prominent. Largely consumed foods are rich sources of phenol polymers, notably black foods traditionally used in East Asia, but other non-edible, easily accessible sources, e.g., seaweeds and wood, have been considered with increasing interest together with waste materials from agro-based industries, primarily grape pomace and other byproducts of fruit and coffee processing. Not in all cases were the main structural components of these materials identified because of their highly heterogeneous nature...
April 14, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28392307/electrically-responsive-core-shell-hybrid-microfibers-for-controlled-drug-release-and-cell-culture
#5
Chuntao Chen, Xiao Chen, Heng Zhang, Qi Zhang, Li Wang, Chenxi Li, Beibei Dai, Jiazhi Yang, Jian Liu, Dongping Sun
It is an active research field to develop fiber-shaped smart materials for biomedical applications. Here we report the development of the multifunctional core-shell hybrid microfibers with excellent mechanical and electrical performance as a new smart biomaterial. The microfibers were synthesized using a combination of co-axial spinning with a microfluidic device and subsequent dip-coating, containing a hydrogel core of bacterial cellulose (BC) and a conductive polymer shell layer of poly(3,4-ethylenedioxythiophene) (PEDOT)...
April 6, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28279921/computational-smart-polymer-design-based-on-elastin-protein-mutability
#6
Anna Tarakanova, Wenwen Huang, Anthony S Weiss, David L Kaplan, Markus J Buehler
Soluble elastin-like peptides (ELPs) can be engineered into a range of physical forms, from hydrogels and scaffolds to fibers and artificial tissues, finding numerous applications in medicine and engineering as "smart polymers". Elastin-like peptides are attractive candidates as a platform for novel biomaterial design because they exhibit a highly tunable response spectrum, with reversible phase transition capabilities. Here, we report the design of the first virtual library of elastin-like protein models using methods for enhanced sampling to study the effect of peptide chemistry, chain length, and salt concentration on the structural transitions of ELPs, exposing associated molecular mechanisms...
May 2017: Biomaterials
https://www.readbyqxmd.com/read/28254064/smart-biomaterials-smarter-medicine
#7
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
February 2017: EBioMedicine
https://www.readbyqxmd.com/read/28243085/continuous-release-of-bone-morphogenetic-protein-2-through-nano-graphene-oxide-based-delivery-influences-the-activation-of-the-nf-%C3%AE%C2%BAb-signal-transduction-pathway
#8
Cheng Zhong, Jun Feng, Xiangjin Lin, Qi Bao
Graphene oxide (GO) has been used as a delivery vehicle for small molecule drugs and nucleotides. To further investigate GO as a smart biomaterial for the controlled release of cargo molecules, we hypothesized that GO may be an appropriate delivery vehicle because it releases bone morphogenetic protein 2 (BMP2). GO characterization indicated that the size distribution of the GO flakes ranged from 81.1 nm to 45,749.7 nm, with an approximate thickness of 2 nm. After BMP2 adsorption onto GO, Fourier-transformed infrared spectroscopy (FTIR) and thermal gravimetric analysis were performed...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28237820/molecular-dynamics-study-on-dna-nanotubes-as-drug-delivery-vehicle-for-anticancer-drugs
#9
Lijun Liang, Jia-Wei Shen, Qi Wang
In recent years, self-assembled DNA nanotubes have emerged as a type of nano-biomaterials with great potential for biomedical applications. To develop universal nanocarriers for smart and targeted drug delivery from DNA nanotubes, the understanding of interaction mechanism between DNA nanotubes and drugs is essential. In this study, the interactions between anti-cancer drugs and DNA nanotubes were investigated via molecular dynamics simulation. Our simulation results demonstrated that the DNA nanotubes could serve as a good drug delivery material by absorption of anti-cancer drugs with π-π interactions...
May 1, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28220178/a-photo-degradable-supramolecular-hydrogel-for-selective-delivery-of-microrna-into-3d-cultured-cells
#10
Zhengquan Zhou, Qikun Yi, Tingting Xia, Wencui Yin, Adnan A Kadi, Jinbo Li, Yan Zhang
Multi-functional supramolecular hydrogels have emerged as smart biomaterials for diverse biomedical applications. Here we report a multi-functional supramolecular hydrogel formed by the conjugate of the bioactive GRGDS peptide with biaryltetrazole that is the substrate of photo-click reaction. The hydrogel was used as a biocompatible matrix to encapsulate live cells for 3D culture. The presence of the RGD epitope in the hydrogelator enhanced the interaction of the nanofiber with integrin over-expressing cells, which resulted in the selective enhancement in the miRNA delivery into the encapsulated U87 cells...
February 21, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28195832/four-dimensional-printing-hierarchy-scaffolds-with-highly-biocompatible-smart-polymers-for-tissue-engineering-applications
#11
Shida Miao, Wei Zhu, Nathan J Castro, Jinsong Leng, Lijie Grace Zhang
The objective of this study was to four-dimensional (4D) print novel biomimetic gradient tissue scaffolds with highly biocompatible naturally derived smart polymers. The term "4D printing" refers to the inherent smart shape transformation of fabricated constructs when implanted minimally invasively for seamless and dynamic integration. For this purpose, a series of novel shape memory polymers with excellent biocompatibility and tunable shape changing effects were synthesized and cured in the presence of three-dimensional printed sacrificial molds, which were subsequently dissolved to create controllable and graded porosity within the scaffold...
October 2016: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28126309/smart-radiation-therapy-biomaterials
#12
REVIEW
Wilfred Ngwa, Francis Boateng, Rajiv Kumar, Darrell J Irvine, Silvia Formenti, Twalib Ngoma, Carsten Herskind, Marlon R Veldwijk, Georg Lars Hildenbrand, Michael Hausmann, Frederik Wenz, Juergen Hesser
Radiation therapy (RT) is a crucial component of cancer care, used in the treatment of over 50% of cancer patients. Patients undergoing image guided RT or brachytherapy routinely have inert RT biomaterials implanted into their tumors. The single function of these RT biomaterials is to ensure geometric accuracy during treatment. Recent studies have proposed that the inert biomaterials could be upgraded to "smart" RT biomaterials, designed to do more than 1 function. Such smart biomaterials include next-generation fiducial markers, brachytherapy spacers, and balloon applicators, designed to respond to stimuli and perform additional desirable functions like controlled delivery of therapy-enhancing payloads directly into the tumor subvolume while minimizing normal tissue toxicities...
March 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28116907/quantitative-control-of-protein-and-cell-interaction-with-nanostructured-surfaces-by-cluster-assembling
#13
Carsten Schulte, Alessandro Podestà, Cristina Lenardi, Gabriella Tedeschi, Paolo Milani
The development of smart prosthetics, scaffolds, and biomaterials for tissue engineering and organ-on-a-chip devices heavily depends on the understanding and control of biotic/abiotic interfaces. In recent years, the nanometer scale emerged as the predominant dimension for processes impacting on protein adsorption and cellular responses on surfaces. In this context, the extracellular matrix (ECM) can be seen as the prototype for an intricate natural structure assembled by nanoscale building blocks forming highly variable nanoscale configurations, dictating cellular behavior and fate...
January 24, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28092777/controlling-the-3d-architecture-of-self-lifting-auto-generated-tissue-equivalents-slates-for-optimized-corneal-graft-composition-and-stability
#14
Ricardo M Gouveia, Elena González-Andrades, Juan C Cardona, Carmen González-Gallardo, Ana M Ionescu, Ingrid Garzon, Miguel Alaminos, Miguel González-Andrades, Che J Connon
Ideally, biomaterials designed to play specific physical and physiological roles in vivo should comprise components and microarchitectures analogous to those of the native tissues they intend to replace. For that, implantable biomaterials need to be carefully designed to have the correct structural and compositional properties, which consequently impart their bio-function. In this study, we showed that the control of such properties can be defined from the bottom-up, using smart surface templates to modulate the structure, composition, and bio-mechanics of human transplantable tissues...
March 2017: Biomaterials
https://www.readbyqxmd.com/read/28080020/biocatalytic-self-assembly-using-reversible-and-irreversible-enzyme-immobilization
#15
M P Conte, K H A Lau, R V Ulijn
Biocatalytic control of molecular self-assembly provides an effective approach for developing smart biomaterials, allowing versatile enzyme-mediated tuning of material structure and properties as well as enabling biomedical applications. We functionalized surfaces with bioinspired polydopamine and polyphenol coatings to study the effects of enzyme surface localization and surface release on the self-assembly process. We show how these coatings could be conveniently used to release enzymes for bulk gelation as well as to irreversibly immobilize enzymes for localizing the self-assembly to the surface...
February 1, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28069504/ph-sensitive-peptide-hydrogel-for-glucose-responsive-insulin-delivery
#16
Xue Li, Mian Fu, Jun Wu, Chenyu Zhang, Xin Deng, Arvind Dhinakar, Wenlong Huang, Hai Qian, Liang Ge
Glucose-responsive system is one of important options for self-regulated insulin delivery to treat diabetes, which has become an issue of great public health concern in the world. In this study, we developed a novel and biocompatible glucose-responsive insulin delivery system using a pH-sensitive peptide hydrogel as a carrier loaded with glucose oxidase, catalase and insulin. The peptide could self-assemble into hydrogel under physiological conditions. When hypoglycemia is encountered, neighboring alkaline amino acid side chains are significantly repulsed due to reduced local pH by the enzymatic conversion of glucose into gluconic acid...
January 6, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28026935/thermoresponsive-semi-ipn-hydrogel-microfibers-from-continuous-fluidic-processing-with-high-elasticity-and-fast-actuation
#17
Yan Liu, Kaihuan Zhang, Jinghong Ma, G Julius Vancso
Hydrogels with rapid and strong response to external stimuli and possessing high elasticity and strength have been considered as platform materials for numerous applications, e.g., in biomaterials engineering. Thermoresponsive hydrogels based on semi-interpenetrating polymer networks (semi-IPN) featuring N-isopropylacrylamide with copolymers of poly(N-isopropylacrylamide-co-hydroxyethyl methacrylate) p(NIPAM-HEMA) chains are prepared and described. The copolymer was characterized by FTIR, NMR, and GPC. The semi-IPN structured hydrogel and its responsive properties were evaluated by dynamic mechanical measurements, SEM, DSC, equilibrium swelling ratio, and dynamic deswelling tests...
December 27, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27992845/pnipam-grafted-surfaces-through-atrp-and-raft-polymerization-chemistry-and-bioadhesion
#18
REVIEW
G Conzatti, S Cavalie, C Combes, J Torrisani, N Carrere, A Tourrette
Biomaterials surface design is critical for the control of materials and biological system interactions. Being regulated by a layer of molecular dimensions, bioadhesion could be effectively tailored by polymer surface grafting. Basically, this surface modification can be controlled by radical polymerization, which is a useful tool for this purpose. The aim of this review is to provide a comprehensive overview of the role of surface characteristics on bioadhesion properties. We place a particular focus on biomaterials functionalized with a brush surface, on presentation of grafting techniques for "grafting to" and "grafting from" strategies and on brush characterization methods...
March 1, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/27989830/hydrogel-based-approaches-for-cardiac-tissue-engineering
#19
Laura Saludas, Simon Pascual-Gil, Felipe Prósper, Elisa Garbayo, María Blanco-Prieto
Heart failure still represents the leading cause of death worldwide. Novel strategies using stem cells and growth factors have been investigated for effective cardiac tissue regeneration and heart function recovery. However, some major challenges limit their translation to the clinic. Recently, biomaterials have emerged as a promising approach to improve delivery and viability of therapeutic cells and proteins for the regeneration of the damaged heart. In particular, hydrogels are considered one of the most promising vehicles...
October 29, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27987788/antibody-coupled-hydroxyapatite-nanoparticles-as-efficient-tools-for-labeling-intracellular-proteins
#20
Fabiola Vázquez-Hernández, Salvador Mendoza-Acevedo, Claudia Oliva Mendoza-Barrera, Julio Mendoza-Álvarez, Juan Pedro Luna-Arias
Smart biomaterials for active targeting are a novel way for biosensing, gene and drug delivery, and bioimaging. The functional additives are chosen according to the material carrier characteristics, i.e. the functional mercapto acids of different lengths. In order to identify the target tissue, cell, organ or molecule, the biomaterial must be equipped with a recognizing molecule on its surface. In most cases, semiconductor o metal materials are employed in bioimaging and biosensing applications; in gene and drug delivery area, it is useful to employ porous nanoparticles as carriers...
February 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
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