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Smart biomaterial

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https://www.readbyqxmd.com/read/28092777/controlling-the-3d-architecture-of-self-lifting-auto-generated-tissue-equivalents-slates-for-optimized-corneal-graft-composition-and-stability
#1
Ricardo M Gouveia, Elena González-Andrades, Juan C Cardona, Carmen González-Gallardo, Ana M Ionescu, Ingrid Garzon, Miguel Alaminos, Miguel González-Andrades, Che J Connon
Ideally, biomaterials designed to play specific physical and physiological roles in vivo should comprise components and microarchitectures analogous to those of the native tissues they intend to replace. For that, implantable biomaterials need to be carefully designed to have the correct structural and compositional properties, which consequently impart their bio-function. In this study, we showed that the control of such properties can be defined from the bottom-up, using smart surface templates to modulate the structure, composition, and bio-mechanics of human transplantable tissues...
December 23, 2016: Biomaterials
https://www.readbyqxmd.com/read/28080020/biocatalytic-self-assembly-using-reversible-and-irreversible-enzyme-immobilization
#2
Maria Paola Conte, King Hang Aaron Lau, Rein V Ulijn
Biocatalytic control of molecular self-assembly provides an effective approach for developing smart biomaterials, allowing versatile enzyme-mediated tuning of material structure and properties as well as biomedical applications. We functionalized surfaces with bioinspired polydopamine and polyphenol coatings to study the effects of enzyme surface localization and surface release on the self-assembly process. We show how these coatings could be conveniently used to release enzymes for bulk gelation as well as to irreversibly immobilize enzymes for localizing the self-assembly to the surface...
January 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28069504/ph-sensitive-peptide-hydrogel-for-glucose-responsive-insulin-delivery
#3
Xue Li, Mian Fu, Jun Wu, Chenyu Zhang, Xin Deng, Arvind Dhinakar, Wenlong Huang, Hai Qian, Liang Ge
: Glucose-responsive system is one of important options for self-regulated insulin delivery to treat diabetes, which has become an issue of great public health concern in the world. In this study, we developed a novel and biocompatible glucose-responsive insulin delivery system using a pH-sensitive peptide hydrogel as a carrier loaded with glucose oxidase, catalase and insulin. The peptide could self-assemble into hydrogel under physiological conditions. When hypoglycemia is encountered, neighboring alkaline amino acid side chains are significantly repulsed due to reduced local pH by the enzymatic conversion of glucose into glucoinc acid...
January 6, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28026935/thermoresponsive-semi-ipn-hydrogel-microfibers-from-continuous-fluidic-processing-with-high-elasticity-and-fast-actuation
#4
Yan Liu, Kaihuan Zhang, Jinghong Ma, G Julius Vancso
Hydrogels with rapid and strong response to external stimuli and possessing high elasticity and strength have been considered as platform materials for numerous applications, e.g., in biomaterials engineering. Thermoresponsive hydrogels based on semi-interpenetrating polymer networks (semi-IPN) featuring N-isopropylacrylamide with copolymers of poly(N-isopropylacrylamide-co-hydroxyethyl methacrylate) p(NIPAM-HEMA) chains are prepared and described. The copolymer was characterized by FTIR, NMR, and GPC. The semi-IPN structured hydrogel and its responsive properties were evaluated by dynamic mechanical measurements, SEM, DSC, equilibrium swelling ratio, and dynamic deswelling tests...
December 27, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27992845/pnipam-grafted-surfaces-through-atrp-and-raft-polymerization-chemistry-and-bioadhesion
#5
REVIEW
G Conzatti, S Cavalie, C Combes, J Torrisani, N Carrere, A Tourrette
Biomaterials surface design is critical for the control of materials and biological system interactions. Being regulated by a layer of molecular dimensions, bioadhesion could be effectively tailored by polymer surface grafting. Basically, this surface modification can be controlled by radical polymerization, which is a useful tool for this purpose. The aim of this review is to provide a comprehensive overview of the role of surface characteristics on bioadhesion properties. We place a particular focus on biomaterials functionalized with a brush surface, on presentation of grafting techniques for "grafting to" and "grafting from" strategies and on brush characterization methods...
December 7, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/27989830/hydrogel-based-approaches-for-cardiac-tissue-engineering
#6
Laura Saludas, Simon Pascual-Gil, Felipe Prósper, Elisa Garbayo, María Blanco-Prieto
Heart failure still represents the leading cause of death worldwide. Novel strategies using stem cells and growth factors have been investigated for effective cardiac tissue regeneration and heart function recovery. However, some major challenges limit their translation to the clinic. Recently, biomaterials have emerged as a promising approach to improve delivery and viability of therapeutic cells and proteins for the regeneration of the damaged heart. In particular, hydrogels are considered one of the most promising vehicles...
October 29, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27987788/antibody-coupled-hydroxyapatite-nanoparticles-as-efficient-tools-for-labeling-intracellular-proteins
#7
Fabiola Vázquez-Hernández, Salvador Mendoza-Acevedo, Claudia Oliva Mendoza-Barrera, Julio Mendoza-Álvarez, Juan Pedro Luna-Arias
Smart biomaterials for active targeting are a novel way for biosensing, gene and drug delivery, and bioimaging. The functional additives are chosen according to the material carrier characteristics, i.e. the functional mercapto acids of different lengths. In order to identify the target tissue, cell, organ or molecule, the biomaterial must be equipped with a recognizing molecule on its surface. In most cases, semiconductor o metal materials are employed in bioimaging and biosensing applications; in gene and drug delivery area, it is useful to employ porous nanoparticles as carriers...
February 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27987712/hyaluronic-acid-doped-poly-3-4-ethylenedioxythiophene-chitosan-gelatin-pedot-ha-cs-gel-porous-conductive-scaffold-for-nerve-regeneration
#8
Shuping Wang, Shui Guan, Zhibo Zhu, Wenfang Li, Tianqing Liu, Xuehu Ma
Conducting polymer, as a "smart" biomaterial, has been increasingly used to construct tissue engineered scaffold for nerve tissue regeneration. In this study, a novel porous conductive scaffold was prepared by incorporating conductive hyaluronic acid (HA) doped-poly(3,4-ethylenedioxythiophene) (PEDOT-HA) nanoparticles into a chitosan/gelatin (Cs/Gel) matrix. The physicochemical characteristics of Cs/Gel scaffold with 0-10wt% PEDOT-HA were analyzed and the results indicated that the incorporation of PEDOT-HA into scaffold increased the electrical and mechanical properties while decreasing the porosity and water absorption...
February 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27987689/leptothrix-sp-sheaths-modified-with-iron-oxide-particles-magnetically-responsive-high-aspect-ratio-functional-material
#9
Ivo Safarik, Ralitsa Angelova, Eva Baldikova, Kristyna Pospiskova, Mirka Safarikova
Smart materials of biological origin are attracting a lot of attention nowadays, especially as catalysts, carriers or adsorbents. Among them, magnetically modified biomaterials are especially important due to their response to external magnetic field. This report demonstrates that naturally occurring micrometer sized, high aspect ratio material (native and autoclaved Leptothrix sp. sheaths) efficiently bind synthetically prepared magnetite and maghemite nanoparticles and their aggregates. Magnetic modification of Leptothrix sheaths enables to prepare a promising material for advanced biotechnology and environmental technology applications...
February 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27981886/additive-manufacturing-of-vascular-grafts-and-vascularized-tissue-constructs
#10
Laura Elomaa, Yunzhi Peter Yang
There is a great need for engineered vascular grafts among patients with cardiovascular diseases who are in need of bypass therapy and lack autologous healthy blood vessels. In addition, because of the severe worldwide shortage of organ donors, there is an increasing need for engineered vascularized tissue constructs as an alternative to organ transplants. Additive manufacturing (AM) offers great advantages and flexibility of fabrication of cell-laden, multimaterial, and anatomically shaped vascular grafts and vascularized tissue constructs...
January 10, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/27934188/nanostructured-montmorillonite-clay-for-controlling-the-lipase-mediated-digestion-of-medium-chain-triglycerides
#11
Tahnee J Dening, Paul Joyce, Shasha Rao, Nicky Thomas, Clive A Prestidge
Biocompatible lipid hybrid particles composed of montmorillonite and medium chain triglycerides were engineered for the first time by spray drying oil-in-water emulsions stabilized by montmorillonite platelets to form montmorillonite-lipid hybrid (MLH) microparticles containing up to 75% w/w lipid. In vitro lipolysis studies under simulated intestinal conditions indicated that the specific porous nanoarchitecture and surface chemistry of MLH particles significantly increased the rate (>10-fold) and extent of lipase-mediated digestion compared to that of coarse and homogenized submicrometer triglyceride emulsions...
December 7, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27893196/guiding-hmsc-adhesion-and-differentiation-on-supported-lipid-bilayers
#12
Gülistan Koçer, Pascal Jonkheijm
Mesenchymal stem cells (MSCs) are intensively investigated for regenerative medicine applications due to their ease of isolation and multilineage differentiation capacity. Hence, designing instructive microenvironments to guide MSC behavior is important for the generation of smart interfaces to enhance biomaterial performance in guiding desired tissue formation. Supported lipid bilayers (SLBs) as cell membrane mimetics can be employed as biological interfaces with easily tunable characteristics such as biospecificity, mobility, and density of predesigned ligand molecules...
November 28, 2016: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/27890732/programmed-near-infrared-light-responsive-drug-delivery-system-for-combined-magnetic-tumor-targeting-magnetic-resonance-imaging-and-chemo-phototherapy
#13
Qianhua Feng, Yuanyuan Zhang, Wanxia Zhang, Yongwei Hao, Yongchao Wang, Hongling Zhang, Lin Hou, Zhenzhong Zhang
: In this study, an intelligent drug delivery system was developed by capping doxorubicin (DOX)-loaded hollow mesoporous CuS nanoparticles (HMCuS NPs) with superparamagnetic iron oxide nanoparticles (IONPs). Under near infrared (NIR) light irradiation, the versatile HMCuS NPs could exploit the merits of both photothermal therapy (PTT) and photodynamic therapy (PDT) simultaneously. Herein, the multifunctional IONPs as gatekeeper with the enhanced capping efficiency were supposed to realize "zero premature release" and minimize the adverse side effects during the drug delivery in vivo...
November 24, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27880013/on-demand-release-of-hydrosoluble-drugs-from-a-paramagnetic-porous-collagen-based-scaffold
#14
Simona Bettini, Valentina Bonfrate, Marta Madaghiele, Luca Salvatore, Zois Syrgiannis, Gabriele Giancane, Ludovico Valli
The design of a collagen scaffold containing iron oxide nanostructures capped by a TiO2 (anatase) layer is reported. The TiO2 shell is proposed to perform a dual role: 1) as an innovative and biocompatible cross-linker agent, providing binding sites to the protein moiety, through the well-known TiO2 chemical affinity towards carboxyl groups, and 2) as a protective surface layer for the paramagnetic core against oxidation. Simultaneously, the presence of the nanostructures confers to the collagen gel sensitivity to an external stimulus; that is, the application of a magnetic field...
November 23, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27814702/biomimetic-approaches-with-smart-interfaces-for-bone-regeneration
#15
REVIEW
G S Sailaja, P Ramesh, Sajith Vellappally, Sukumaran Anil, H K Varma
A 'smart tissue interface' is a host tissue-biomaterial interface capable of triggering favourable biochemical events inspired by stimuli responsive mechanisms. In other words, biomaterial surface is instrumental in dictating the interface functionality. This review aims to investigate the fundamental and favourable requirements of a 'smart tissue interface' that can positively influence the degree of healing and promote bone tissue regeneration. A biomaterial surface when interacts synergistically with the dynamic extracellular matrix, the healing process become accelerated through development of a smart interface...
November 5, 2016: Journal of Biomedical Science
https://www.readbyqxmd.com/read/27796463/defining-the-properties-of-an-array-of-nh2-modified-substrates-for-the-induction-of-a-mature-osteoblast-osteocyte-phenotype-from-a-primary-human-osteoblast-population-using-controlled-nanotopography-and-surface-chemistry
#16
Sandra A Fawcett, Judith M Curran, Rui Chen, Nicholas P Rhodes, Mark F Murphy, Peter Wilson, Lakshminarayan Ranganath, Jane P Dillon, James A Gallagher, John A Hunt
Accelerating the integration of a joint replacement or the healing of a bone fracture, particularly a complicated non-union fracture, would improve patient welfare and decrease healthcare costs. Currently, an autologous bone graft is the gold standard method for the treatment of complicated non-union fractures, but it is not always possible to harvest such a graft. A proactive highly inductive so-called smart material approach is pertinent in these cases. In this study, the surface chemistry of a previously approved material with desirable bulk material properties was modified to investigate its potential as an economical and effective alternative...
October 28, 2016: Calcified Tissue International
https://www.readbyqxmd.com/read/27782402/3d-printing-of-photoresponsive-biomaterials-for-control-of-bacterial-microenvironments
#17
Jodi L Connell, Eric T Ritschdorff, Jason B Shear
Advances in microscopic three-dimensional (µ3D) printing provide a means to microfabricate an almost limitless range of arbitrary geometries, offering new opportunities to rapidly prototype complex architectures for microfluidic and cellular applications. Such 3D lithographic capabilities present the tantalizing prospect for engineering micromechanical components - for example, pumps and valves - for cellular environments comprised of smart materials whose size, shape, permeability, stiffness, and other attributes might be modified in real time to precisely manipulate ultra-low-volume samples...
October 26, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27721086/electroconductive-natural-polymer-based-hydrogels
#18
Zhijun Shi, Xing Gao, Muhammad Wajid Ullah, Sixiang Li, Qun Wang, Guang Yang
Hydrogels prepared from natural polymers have received immense considerations over the past decade due to their safe nature, biocompatibility, hydrophilic properties, and biodegradable nature. More recently, when treated with electroactive materials, these hydrogels were endowed with high electrical conductivity, electrochemical redox properties, and electromechanical properties; consequently, forming a smart hydrogel. The biological properties of these smart hydrogels, classified as electroconductive hydrogels, can be combined with electronics...
December 2016: Biomaterials
https://www.readbyqxmd.com/read/27718479/fabrication-of-multifunctional-cap-tc-composite-coatings-and-the-corrosion-protection-they-provide-for-magnesium-alloys
#19
Cui Tan, Xiaoxu Zhang, Qing Li
Two major problems with magnesium (Mg) alloy biomaterials are the poor corrosion resistance and infection associated with implantation. In this study, a novel calcium phosphate (CaP)/tetracycline (TC) composite coating for Mg implants that can both improve the corrosion resistance of Mg and release a drug in a durable way is reported. Scanning electron microscope (SEM) images showed that TC additives make the CaP coating more compact and uniform. Electrochemical tests indicated CaP/TC coatings can provide excellent corrosion protection for Mg alloy substrates...
October 8, 2016: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/27714161/inflammation-sensitive-in-situ-smart-scaffolding-for-regenerative-medicine
#20
Hirak K Patra, Yashpal Sharma, Mohammad Mirazul Islam, Mohammad Javad Jafari, N Arul Murugan, Hisatoshi Kobayashi, Anthony P F Turner, Ashutosh Tiwari
To cope with the rapid evolution of the tissue engineering field, it is now essential to incorporate the use of on-site responsive scaffolds. Therefore, it is of utmost importance to find new 'Intelligent' biomaterials that can respond to the physicochemical changes in the microenvironment. In this present report, we have developed biocompatible stimuli responsive polyaniline-multiwalled carbon nanotube/poly(N-isopropylacrylamide), (PANI-MWCNT/PNIPAm) composite nanofiber networks and demonstrated the physiological temperature coordinated cell grafting phenomenon on its surface...
October 6, 2016: Nanoscale
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