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https://www.readbyqxmd.com/read/28448463/thymoquinone-defeats-diabetes-induced-testicular-damage-in-rats-targeting-antioxidant-inflammatory-and-aromatase-expression
#1
Mustafa S Atta, Essam A Almadaly, Ali H El-Far, Rasha M Saleh, Doaa H Assar, Soad K Al Jaouni, Shaker A Mousa
Antioxidants have valuable effects on the process of spermatogenesis, particularly with diabetes mellitus (DM). Therefore, the present study investigated the impact and the intracellular mechanisms by which thymoquinone (TQ) works against diabetes-induced testicular deteriorations in rats. Wistar male rats (n = 60) were randomly allocated into four groups; Control, Diabetic (streptozotocin (STZ)-treated rats where diabetes was induced by intraperitoneal injection of STZ, 65 mg/kg), Diabetic + TQ (diabetic rats treated with TQ (50 mg/kg) orally once daily), and TQ (non-diabetic rats treated with TQ) for 12 weeks...
April 27, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28445960/effect-of-folate-deficiency-on-promoter-methylation-and-gene-expression-of-esr1-cav1-and-elavl1-and-its-influence-on-spermatogenesis
#2
Hong-Fang Yuan, Kai Zhao, Yu Zang, Chun-Yan Liu, Zhi-Yong Hu, Jia-Jing Wei, Ting Zhou, Ying Li, Hui-Ping Zhang
This study aims to investigate the effect of folate deficiency on the male reproductive function and the underlying mechanism. A total of 269 screened participants from 421 recruitments were enrolled in this study. An animal model of folate deficiency was constructed. Folate concentration was measured in the ejaculate, and its association with semen parameters was then determined. The expression and promoter methylation status of ESR1, CAV1, and ELAVL1 were also evaluated. Results showed that seminal plasma folate level was significantly lower among subjects with azoospermia than those with normozoospermia...
April 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28444970/quality-of-life-of-immigrant-and-non-immigrant-infertile-patients-in-a-publicly-funded-in-vitro-fertilization-program-a-cross-sectional-study
#3
J Hasson, T Tulandi, T Shavit, T Shaulov, E Seccareccia, J Takefman
OBJECTIVE: To investigate whether there are differences in fertility quality of life (FertiQoL) and socio-demographic characteristics between immigrants and non-immigrant patients attending a government funded fertility program DESIGN: Cross-sectional study SETTING: McGill University reproductive center in Montreal, Canada, in a time when governmental funding for In-Vitro Fertilization (IVF) was provided to all residents POPULATION: All infertile patients, males and females, attending the center between March to July 2015...
April 26, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28444774/protective-effect-of-l-carnitine-and-l-arginine-against-busulfan-induced-oligospermia-in-adult-rat
#4
A M Abd-Elrazek, O A H Ahmed-Farid
Busulfan is an anticancer drug caused variety of adverse effects for patients with cancer. But it could cause damage to the male reproductive system as one of its adverse effects. This study aimed to investigate the protective effect of L-carnitine and L-arginine on semen quality, oxidative stress parameters and testes cell energy after busulfan treatment. Adult male rats were divided into four groups: control (Con), busulfan (Bus), busulfan plus L-arginine (Bus + L-arg) and busulfan plus L-carnitine (Bus + L-car)...
April 25, 2017: Andrologia
https://www.readbyqxmd.com/read/28444173/tac1-signaling-is-required-for-sexual-maturation-and-responsiveness-of-gnrh-neurons-to-kisspeptin-in-the-male-mouse
#5
Caroline A Maguire, Yong Bhum Song, Min Wu, Silvia León, Rona S Carroll, Meenakshi Alreja, Ursula B Kaiser, Víctor M Navarro
The tachykinins substance P (SP) and neurokinin A (NKA) (Tac1) have emerged as novel regulators of kisspeptin/GnRH release. Recently, we documented that SP modulates reproductive function in the female mouse. Here, we extended this characterization to the male mouse. Tac1-/- male mice showed delayed puberty onset. They also presented significantly decreased expression levels of Pdyn (dynorphin) and Nos1 (nitric oxide synthase) in the mediobasal hypothalamus and elevated Gnrh1 levels. Unexpectedly, the response of Tac1-/- mice to central kisspeptin or senktide (neurokinin B receptor -NK3R- agonist) administration was significantly decreased compared with controls, despite the preserved ability of GnRH neurons to stimulate LH release as demonstrated by central NMDA administration, suggesting a deficit at the GnRH neuron level...
April 21, 2017: Endocrinology
https://www.readbyqxmd.com/read/28444146/nonsense-in-the-testis-multiple-roles-for-nonsense-mediated-decay-revealed-in-male-reproduction
#6
Clinton C MacDonald, Petar N Grozdanov
Nonsense-mediated mRNA decay, or NMD, is a quality control mechanism that identifies cytoplasmic mRNAs containing translational termination (stop) codons in specific contexts - either premature termination codons or unusually long 3΄ untranslated regions - and targets them for degradation. In recent studies, researchers in different labs have knocked out important genes involved in NMD, Upf2 and Upf3a, and one component of chromatoid bodies, Tdrd6, and examined the consequences for spermatogenesis. Disruption of Upf2 during early stages of spermatogenesis resulted in disappearance of nearly all spermatogenic cells through loss of NMD...
April 22, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28443373/association-between-women-s-empowerment-and-maternal-and-child-nutrition-in-kalal%C3%A3-district-of-northern-benin
#7
Halimatou Alaofè, Min Zhu, Jennifer Burney, Rosamond Naylor, Taren Douglas
BACKGROUND: Evidence on effectiveness of women's empowerment (WE) to reduce undernutrition is limited in sub-Sahara Africa, and few studies incorporate multidimensional measures of WE. OBJECTIVE: To examine whether a WE status, in sum and across leadership, decision-making, mobility, economic security, male involvement in housework, and nonfamily group domains, is associated with women and their children nutritional status in Kalalé district of northern Benin. METHODS: Data were obtained from the 2014 Solar Market Garden baseline study: 767 paired reproductive-age women aged 15 to 49 years and children 6 to 59 months old...
January 1, 2017: Food and Nutrition Bulletin
https://www.readbyqxmd.com/read/28443181/development-of-a-test-method-for-the-evaluation-of-dna-damage-in-mouse-spermatogonial-stem-cells
#8
Hye Lyun Jeon, Jung-Sun Yi, Tae Sung Kim, Youkyung Oh, Hye Jeong Lee, Minseong Lee, Jin Seok Bang, Kinarm Ko, Il Young Ahn, Kyungyuk Ko, Joohwan Kim, Hye-Kyung Park, Jong Kwon Lee, Soo Jung Sohn
Although alternative test methods based on the 3Rs (Replacement, Reduction, Refinement) are being developed to replace animal testing in reproductive and developmental toxicology, they are still in an early stage. Consequently, we aimed to develop alternative test methods in male animals using mouse spermatogonial stem cells (mSSCs). Here, we modified the OECD TG 489 and optimized the in vitro comet assay in our previous study. This study aimed to verify the validity of in vitro tests involving mSSCs by comparing their results with those of in vivo tests using C57BL/6 mice by gavage...
April 2017: Toxicological Research
https://www.readbyqxmd.com/read/28442349/perinatal-programming-of-the-orexinergic-hypocretinergic-system-in-hypothalamus-and-anterior-pituitary-by-testosterone
#9
Natalia I Cataldi, Victoria A Lux-Lantos, Carlos Libertun
Orexins A/B derived from hypothalamic prepro-orexin (PPO) are agonists for orexin receptors 1 (OX1) and 2 (OX2). Previously, we showed clear sex differences in the hypothalamic-pituitary-gonadal orexinergic system in adult rodents. Here, we studied the effect of sexual brain differentiation on the orexinergic system in neuroendocrine structures regulating reproduction. We evaluated: a: proestrous and neonatally androgenized female rats; b: adult males, untreated or gonadectomized in adulthood and injected with oil or estradiol and progesterone (E2/P4); c: control and demasculinized males (perinatally treated with flutamide and later castration) injected either with oil or E2/P4 in adulthood...
April 22, 2017: Peptides
https://www.readbyqxmd.com/read/28441596/individual-variation-of-persistent-organic-pollutants-in-relation-to-stable-isotope-ratios-sex-reproductive-phase-and-oxidative-status-in-scopoli-s-shearwaters-calonectris-diomedea-from-the-southern-mediterranean
#10
David Costantini, Manrico Sebastiano, Martina S Müller, Igor Eulaers, Per Ambus, Govindan Malarvannan, Adrian Covaci, Bruno Massa, Giacomo Dell'Omo
Little is known about the accumulation of persistent organic pollutants (POPs) and its consequences for seabirds in the Mediterranean basin. We characterised the plasma contaminant profile (polychlorinated biphenyls ΣPCBs; organochlorine pesticides ΣOCPs; polybrominated diphenyl ethers ΣPBDEs) of a population of the seabird Scopoli's shearwater (Calonectris diomedea) that breeds in the southern Mediterranean (Linosa Island) and investigated (i) whether sex, stable isotope ratios (related to diet), reproductive phase (early incubation vs...
April 22, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28441547/phthalate-exposure-even-below-us-epa-reference-doses-was-associated-with-semen-quality-and-reproductive-hormones-prospective-marhcs-study-in-general-population
#11
Qing Chen, Huan Yang, Niya Zhou, Lei Sun, Huaqiong Bao, Lu Tan, Hongqiang Chen, Xi Ling, Guowei Zhang, Linping Huang, Lianbing Li, Mingfu Ma, Hao Yang, Xiaogang Wang, Peng Zou, Kaige Peng, Taixiu Liu, Xiefei Shi, Dejian Feng, Ziyuan Zhou, Lin Ao, Zhihong Cui, Jia Cao
BACKGROUND: Environment-Protection-Agency Reference Doses (EPA RfDs) for phthalate intakes are based on limited evidence, especially regarding low-dose male-reproductive toxicity. This study investigates the association between phthalate exposure and semen parameters and reproductive hormones in a general population with low phthalate exposure compared to the EPA RfDs. METHODS: The MARHCS (Male-Reproductive-Health-in-Chongqing-College-Students) cohort recruited 796 male students, who experienced a relocation of campuses and shifting environmental exposure...
April 22, 2017: Environment International
https://www.readbyqxmd.com/read/28441342/of-oestrogens-and-sperm-a-review-of-the-roles-of-oestrogens-and-oestrogen-receptors-in-male-reproduction
#12
REVIEW
Pavla Dostalova, Eva Zatecka, Katerina Dvorakova-Hortova
The crucial role that oestrogens play in male reproduction has been generally accepted; however, the exact mechanism of their action is not entirely clear and there is still much more to be clarified. The oestrogen response is mediated through oestrogen receptors, as well as classical oestrogen receptors' variants, and their specific co-expression plays a critical role. The importance of oestrogen signalling in male fertility is indicated by the adverse effects of selected oestrogen-like compounds, and their interaction with oestrogen receptors was proven to cause pathologies...
April 25, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28440870/intensity-of-male-male-competition-predicts-morph-diversity-in-a-colour-polymorphic-lizard
#13
Guillem Pérez I de Lanuza, Miguel A Carretero, Enrique Font
Sexual selection is one of the main processes involved in the emergence and maintenance of heritable colour polymorphisms in a variety of taxa. Here we test whether the intensity of sexual selection, estimated from population sex ratio, predicts morph diversity in Podarcis muralis, a colour polymorphic lizard with discrete white, yellow, orange, white-orange, and yellow-orange male and female phenotypes (i.e. morphs). In a sample of 116 Pyrenean populations and 5421 lizards, sex ratios (m/f) vary from 0.29 to 2...
April 25, 2017: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/28440264/use-of-testicular-sperm-for-intracytoplasmic-sperm-injection-in-men-with-high-sperm-dna-fragmentation-a-swot-analysis
#14
Sandro C Esteves, Matheus Roque, Nicolás Garrido
Spermatozoa retrieved from the testis of men with high levels of sperm DNA fragmentation (SDF) in the neat semen tend to have better DNA quality. Given the negative impact of SDF on the outcomes of Assisted Reproductive Technology (ART), an increased interest has emerged about the use of testicular sperm for intracytoplasmic sperm injection (Testi-ICSI). In this article, we used a SWOT (strengths, weaknesses, opportunities, and threats) analysis to summarize the advantages and drawbacks of this intervention...
April 18, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28439067/perfluorooctanesulfonate-pfos-induced-sertoli-cell-injury-through-a-disruption-of-f-actin-and-microtubule-organization-is-mediated-by-akt1-2
#15
Ying Gao, Haiqi Chen, Xiang Xiao, Wing-Yee Lui, Will M Lee, Dolores D Mruk, C Yan Cheng
PFOS (perfluorooctanesulfonate, or perfluorooctane sulfonic acid) is an anthropogenic fluorosurfactant widely used in consumer products. While its use in Europe, Canada and the U.S. has been banned due to its human toxicity, it continues to be used in China and other developing countries as a global pollutant. Herein, using an in vitro model of Sertoli cell blood-testis barrier (BTB), PFOS was found to induce Sertoli cell injury by perturbing actin cytoskeleton through changes in the spatial expression of actin regulatory proteins...
April 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28439006/murine-model-indicates-22q11-2-signaling-adaptor-crkl-is-a-dosage-sensitive-regulator-of-genitourinary-development
#16
Meade Haller, Qianxing Mo, Akira Imamoto, Dolores J Lamb
The spectrum of congenital anomalies affecting either the upper tract (kidneys and ureters) or lower tract (reproductive organs) of the genitourinary (GU) system are fundamentally linked by the developmental origin of multiple GU tissues, including the kidneys, gonads, and reproductive ductal systems: the intermediate mesoderm. Although ∼31% of DiGeorge/del22q11.2 syndrome patients exhibit GU defects, little focus has been placed on the molecular etiology of GU defects in this syndrome. Among del22q11.2 patients exhibiting GU anomalies, we have mapped the smallest relevant region to only five genes, including CRKLCRKL encodes a src-homology adaptor protein implicated in mediating tyrosine kinase signaling, and is expressed in the developing GU-tract in mice and humans...
April 24, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28438864/partial-deletions-of-y-chromosome-in-infertile-men-with-non-obstructive-azoospermia-and-oligoasthenoteratozoospermia-in-a-turkish-population
#17
Cemallettin Cengiz Beyaz, Sezgin Gunes, Kadir Onem, Tuba Kulac, Ramazan Asci
Many genetic alterations have been identified to aid in understanding the genetic basis of male infertility, however, the cause of 30% of male infertility remains unknown. Some studies indicated that subdeletions of Y chromosome may be a reason for male infertility caused by testicular failure. In this regard, we aimed to investigate frequency of AZFc region subdeletions and their clinical effects in patients with idiopathic infertility. A total of 333 male infertile patients with non-obstructive azoospermia (NOA) or oligoasthenoteratozoospermia (OAT), and 87 normozoospermic controls were screened to detect gr/gr, b1/b3 and b2/b3 subdeletions...
May 2017: In Vivo
https://www.readbyqxmd.com/read/28438852/the-use-of-proteomics-in-assisted-reproduction
#18
REVIEW
Ioanna Kosteria, Athanasios K Anagnostopoulos, Christina Kanaka-Gantenbein, George P Chrousos, George T Tsangaris
Despite the explosive increase in the use of Assisted Reproductive Technologies (ART) over the last 30 years, their success rates remain suboptimal. Proteomics is a rapidly-evolving technology-driven science that has already been widely applied in the exploration of human reproduction and fertility, providing useful insights into its physiology and leading to the identification of numerous proteins that may be potential biomarkers and/or treatment targets of a successful ART pregnancy. Here we present a brief overview of the techniques used in proteomic analyses and attempt a comprehensive presentation of recent data from mass spectrometry-based proteomic studies in humans, regarding all components of ARTs, including the male and female gamete, the derived zygote and embryo, the endometrium and, finally, the ART offspring both pre- and postnatally...
May 2017: In Vivo
https://www.readbyqxmd.com/read/28438692/temporal-variation-in-the-operational-sex-ratio-and-male-mating-behaviours-in-reindeer-rangifer-tarandus
#19
Robert B Weladji, Guillaume Body, Øystein Holand, Xiuxiang Meng, Mauri Nieminen
In polygynous species, sexual selection is mostly driven by male ability to monopolize access to females in oestrous. In ungulates, the operational sex ratio (OSR), i.e. the proportion of males to individuals ready to mate, varies throughout the peak rut, resulting from the temporal variation in the number of females in oestrous. But the way males adjust their mating tactics to maximise their access to females in oestrous (i.e. as OSR varies) is yet to be investigated. Using 15 years of behavioural observations in reindeer (Rangifer tarandus), we compared the relative importance of time within the rutting season (days to the peak-rut) and the OSR to explain the variation in the propensity (i...
April 21, 2017: Behavioural Processes
https://www.readbyqxmd.com/read/28438518/testicular-spermatogenesis-and-sperm-morphology-in-martarega-bentoi-heteroptera-notonectidae
#20
Ademária M Novais, Glenda Dias, José Lino-Neto
The testicular, spermatogenesis and sperm morphology of the backswimmer Martarega bentoi was described using light and transmission electron microscopy. In this species, a pair of testes, two deferent ducts, two different pairs of accessory glands, and an ejaculatory duct form the male reproductive system. Each testis consists of two testicular follicles, which are arranged side by side in snail shape. The follicles are filled with cysts at different stages of spermatogenesis, but in the same cyst the germ cells (up to 64) are in the same stage...
April 21, 2017: Arthropod Structure & Development
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