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https://www.readbyqxmd.com/read/28925605/predictivity-of-nonclinical-male-reproductive-findings-for-human-effects
#1
Anthony R Scialli, Richard V Clark, Robert E Chapin
BACKGROUND: Testing of pharmaceutical products for reproductive toxicity in male laboratory animals is required for registration. METHODS: We evaluated whether the results of studies showing male reproductive toxicity in experimental animals was predictive of reproductive effects in men participating in clinical trials. We surveyed companies for information on pharmaceutical candidates that had shown male reproductive toxicity in nonclinical studies for which there was information on male reproductive effects in clinical trials...
September 19, 2017: Birth defects research
https://www.readbyqxmd.com/read/28923067/a-new-insight-into-male-fertility-preservation-for-patients-with-completely-immotile-spermatozoa
#2
Huanhua Chen, Guixue Feng, Bo Zhang, Hong Zhou, Caizhu Wang, Jinhui Shu, Xianyou Gan, Ruoyun Lin, Dongmei Huang, Yingqin Huang
BACKGROUND: Sperm cryopreservation is the most effective method to preserve male fertility but this is normally used for motile spermatozoa. Thus, only motile spermatozoa are used for cryopreservation in most reproductive medicine centers worldwide. The immotile spermatozoa from some problematic patients are usually discarded, resulting in a missed opportunity of sterility cryopreservation for future assisted reproductive treatments. Many studies have shown that successful fertilization can be obtained after selection of viable sperm from the completely immotile spermatozoa before ICSI...
September 18, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28921784/the-evolution-of-gonad-expenditure-and-gonadosomatic-index-gsi-in-male-and-female-broadcast-spawning-invertebrates
#3
Geoff A Parker, Steven A Ramm, Jussi Lehtonen, Jonathan M Henshaw
Sedentary broadcast-spawning marine invertebrates, which release both eggs and sperm into the water for fertilization, are of special interest for sexual selection studies. They provide unique insight into the early stages of the evolutionary succession leading to the often-intense operation of both pre- and post-mating sexual selection in mobile gonochorists. Since they are sessile or only weakly mobile, adults can interact only to a limited extent with other adults and with their own fertilized offspring...
September 18, 2017: Biological Reviews of the Cambridge Philosophical Society
https://www.readbyqxmd.com/read/28920796/successful-laparoscopic-oviductal-artificial-insemination-in-the-clouded-leopard-neofelis-nebulosa-in-thailand
#4
Wanlaya Tipkantha, Paweena Thuwanut, Umaporn Maikeaw, Ampika Thongphakdee, Saifon Yapila, Sumate Kamolnorranath, Boripat Siriaroonrat, Pierre Comizzoli, Kaywalee Chatdarong
Captive breeding of clouded leopards (Neofelis nebulosa) is challenging because of mating incompatibility, high incidence of teratospermia in males, and inconsistent ovulation patterns in females. Assisted reproductive techniques, therefore, are necessary to overcome these issues and maintain the genetic diversity in the captive population. The objective was to use laparoscopic oviductal artificial insemination (AI) to breed genetically valuable females (n = 4; aged 4.5-5 yr) that were unsuccessfully paired...
September 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28920783/successful-reduction-of-feather-damaging-behavior-by-social-restructuring-in-a-group-of-golden-conures-guaruba-guarouba
#5
Mathias Dislich, Ulrich Neumann, Lorenzo Crosta
A variety of infectious and noninfectious causes may contribute to feather-damaging behavior (FDB) in birds. This paper describes an episode of FDB behavior related to an isosexual group composition in a group of 20 golden conures (Guaruba guarouba) kept in a collective aviary. After ruling out infectious causative agents and analyzing the social bird group composition over a period of 10 yr, the male to female ratio of the group was reduced from 1.7 to 1.0. This intervention resulted in a significant improvement of the feather condition and improved reproduction...
September 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28919973/study-of-male-mediated-gene-flow-across-a-hybrid-zone-in-the-common-shrew-sorex-araneus-using-y-chromosome
#6
Andrei V Polyakov, Viktor V Panov
Despite many studies, the impact of chromosome rearrangements on gene flow between chromosome races of the common shrew (Sorex araneus Linnaeus, 1758) remains unclear. Interracial hybrids form meiotic chromosome complexes that are associated with reduced fertility. Nevertheless comprehensive investigations of autosomal and mitochondrial markers revealed weak or no barrier to gene flow between chromosomally divergent populations. In a narrow zone of contact between the Novosibirsk and Tomsk races hybrids are produced with extraordinarily complex configurations at meiosis I...
2017: Comparative Cytogenetics
https://www.readbyqxmd.com/read/28918748/new-data-on-programmed-risks-of-death-in-normal-mice-and-mutants-with-growth-delay
#7
A G Malygin
Study of the lifespans of normal (non mutant) mice and growth delay mutants has shown that mortality rates for both kinds of animals exhibit reproducible fluctuations. In the case of the mutant mice, the positions of peaks on the differential mortality curves (mortality rate plotted against lifespan) coincided in different-sex groups of animals and in same-sex subgroups of animals. Differential mortality curves of the mutant mice also had a peak at 1 month of age that was absent from the differential mortality curves of the normal mice...
July 2017: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/28917945/toxic-responses-of-perna-viridis-hepatopancreas-exposed-to-ddt-benzo-a-pyrene-and-their-mixture-uncovered-by-itraq-based-proteomics-and-nmr-based-metabolomics
#8
Qinqin Song, Hailong Zhou, Qian Han, Xiaoping Diao
Dichlorodiphenyltrichloroethane (DDT) and benzo(a)pyrene (BaP) are environmental estrogens (EEs) that are ubiquitous in the marine environment. In the present study, we integrated isobaric tags for relative and absolute quantitation (iTRAQ)-based proteomic and nuclear magnetic resonance (NMR)-based metabolomic approaches to explore the toxic responses of green mussel hepatopancreas exposed to DDT (10μg/L), BaP (10μg/L) and their mixture. The metabolic responses indicated that BaP primarily disturbed energy metabolism and osmotic regulation in the hepatopancreas of the male green mussel P...
September 11, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28917944/tetrabromoethylcyclohexane-affects-gonadal-differentiation-and-development-in-the-frog-pelophylax-nigromaculatus
#9
Peng-Yan Liu, Tan Meng, Yuan-Yuan Li, Man Cai, Xing-Hong Li, Juan Chen, Zhan-Fen Qin
Tetrabromoethylcyclohexane (TBECH), an additive brominated flame retardant, has been shown to have an androgenic activity in vitro. In the present study, we aimed to investigate the effects of TBECH on gonadal differentiation and development in the frog Pelophylax nigromaculatus, an amphibian species sensitive to androgenic chemicals, and to assess the androgenic activity of TBECH in vivo. P. nigromaculatus tadpoles were exposed to TBECH (1, 10, 100nM) from Gosner stage 24 to complete metamorphosis, and to 5α-dihydrotestosterone (DHT) as a positive control...
September 9, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28917444/developing-a-hospital-wide-fertility-preservation-service-for-pediatric-and-young-adult-patients
#10
Claire A Carlson, Thomas F Kolon, Peter Mattei, Wendy Hobbie, Clarisa R Gracia, Sue Ogle, Jill P Ginsberg
PURPOSE: Gonadal damage is a common consequence of treatment for pediatric malignancies. Nononcologic conditions may also utilize treatments with potential impact on fertility. Models for oncology fertility preservation programs have emerged and demonstrate that a multidisciplinary team approach can have a positive impact on referral patterns, appropriate risk counseling, and access to fertility preservation options. Expansion of programmatic breadth is needed, providing improved care to nonmalignant conditions where the disease itself may impact reproductive health or treatment modalities...
September 13, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28917309/toxic-action-of-acmella-oleracea-extract-on-the-male-reproductive-system-of-amblyomma-cajennense-ticks
#11
Luís Adriano Anholeto, Patrícia Rosa de Oliveira, Rodney Alexandre Ferreira Rodrigues, Lais Thiemi Yamane, Karina Neoob de Carvalho Castro, Allan Roberto Fernandes Ferreira, Maria Izabel Camargo-Mathias
The present study evaluated through morphohistological and histochemical techniques the effects of different concentrations of crude ethanolic extract of A. oleracea (EEAO) (Jambu) on the male reproductive system of Amblyomma cajennense sensu stricto (s.s.) ticks. The toxicity of this natural chemical was stablished, signalizing the promising potential of the compound as a strategy to control ectoparasites in the near future. For the experiment, 100 males fed on host rabbits with homogeneous weight (p>0...
September 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28916783/differential-regulation-of-vaginal-lipocalins-obp-mup-during-the-estrous-cycle-of-the-house-mouse
#12
Martina Černá, Barbora Kuntová, Pavel Talacko, Romana Stopková, Pavel Stopka
Female house mice produce pheromone-carrying major urinary proteins (MUPs) in a cycling manner, thus reaching the maximum urinary production just before ovulation. This is thought to occur to advertise the time of ovulation via deposited urine marks. This study aimed to characterize the protein content from the house mouse vaginal flushes to detect putative vaginal-advertising molecules for a direct identification of reproductive states. Here we show that the mouse vaginal discharge contains lipocalins including those from the odorant binding (OBP) and major urinary (MUP) protein families...
September 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28915398/masculinization-and-reproductive-effects-in-western-mosquitofish-gambusia-affinis-after-long-term-exposure-to-androstenedione
#13
Li-Ping Hou, Yang Yang, Hu Shu, Guang-Guo Ying, Jian-Liang Zhao, Gui-Zhen Fang, Li Xin, Wen-Jun Shi, Li Yao, Xue-Mei Cheng
Androstenedione (AED) is a naturally occurring steroid hormone. It is metabolized to potent androgens, which may induce androgenic effects in fish. However, little is known whether and how the androgens interfere with the fish gonadal development and reproduction. This study aimed at demonstrating the effects of long-term AED exposure on reproduction and development in mosquitofish (Gambusia affinis). The growth, development and several morphological endpoints, including the segment number and length of anal fin, histological changes of gonads and liver, were evaluated in mosquitofish during development from fertilized embryo to adulthood (180 days) after exposure of AED at environmentally relevant concentrations...
September 12, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28915245/effects-of-gnrh-vaccination-in-wild-and-captive-african-elephant-bulls-loxodonta-africana-on-reproductive-organs-and-semen-quality
#14
Imke Lueders, Debbie Young, Liana Maree, Gerhard van der Horst, Ilse Luther, Stephan Botha, Brendan Tindall, Geoffrey Fosgate, André Ganswindt, Henk J Bertschinger
OBJECTIVES: Although the African elephant (Loxodonta africana) is classified as endangered by the International Union for Conservation of Nature (IUCN), in some isolated habitats in southern Africa, contraception is of major interest due to local overpopulation. GnRH vaccination has been promoted as a non-invasive contraceptive measure for population management of overabundant wildlife. We tested the efficacy of this treatment for fertility control in elephant bulls. METHODS: In total, 17 male African elephants that were treated with a GnRH vaccine were examined in two groups...
2017: PloS One
https://www.readbyqxmd.com/read/28912601/phf7-a-novel-male-gene-influences-female-fecundity-and-population-growth-in-nilaparvata-lugens-st%C3%A3-l-hemiptera-delphacidae
#15
Lin-Quan Ge, Ting Xia, Bo Huang, Hao-Tian Gu, Qi-Sheng Song, Guo-Qing Yang, Fang Liu, Jin-Cai Wu
PHF7 exhibits male-specific expression in early germ cells, germline stem cells and spermatogonia in insects, and its expression promotes spermatogenesis in germ cells when they are present in a male soma. However, the influence of male-specific PHF7 on female reproductive biology via mating remains unclear. Thus, we investigated the potential impacts of male PHF7, existed in seminal fluid of Nilaparvata lugens (NlPHF7), on fecundity and population growth via mating. Our results revealed that suppressing male NlPHF7 expression by RNAi led to decreases in body weight, soluble accessory gland protein content, arginine content, and reproductive organ development in males, resulting in significant reduction of oviposition periods and fecundity in females, and significant decrease in body weight, fat body and ovarian protein content, yeast-like symbionts abundance, ovarian development and vitellogenin gene expression in their female mating partners...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28912046/seasonal-expression-of-luteinizing-hormone-receptor-and-follicle-stimulating-hormone-receptor-in-testes-of-the-wild-ground-squirrels-citellus-dauricus-brandt
#16
Junjie Wang, Ying Wang, Manyu Zhu, Fengwei Zhang, Xia Sheng, Haolin Zhang, Yingying Han, Zhengrong Yuan, Qiang Weng
The objective of this study was to evaluate whether luteinizing hormone (LH), follicle stimulating hormone (FSH) and their receptors luteinizing hormone receptor (LHR) and follicle stimulating hormone receptor (FSHR) play roles in the seasonal spermatogenesis of the wild ground squirrels. To that end, we characterized the testicular immunolocalization of LHR and FSHR, their expression on both mRNA and protein levels, as well as serum concentrations of LH and FSH in male wild ground squirrels throughout the annual reproductive cycle...
September 11, 2017: Acta Histochemica
https://www.readbyqxmd.com/read/28911868/central-and-peripheral-expression-sites-of-phoenixin-14-immunoreactivity-in-rats
#17
Philip Prinz, Sophie Scharner, Tiemo Friedrich, Martha Schalla, Miriam Goebel-Stengel, Matthias Rose, Andreas Stengel
Phoenixin is a pleiotropic peptide involved in reproduction, anxiety and recently also implicated in the control of food intake. Besides the 20-amino acid phoenixin, the 14-amino acid phoenixin-14 also shows bioactive properties. However, the expression sites of phoenixin-14 in the brain and peripheral tissues are not yet described in detail. Therefore, a mapping of the brain and peripheral tissues from male and female Sprague-Dawley rats with a specific phoenixin-14 antibody was performed using western blot and immunohistochemistry...
September 11, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28911800/evolution-of-the-sex-ratio-and-effective-number-under-gynodioecy-and-androdioecy
#18
Marcy K Uyenoyama, Naoki Takebayashi
We address the evolution of effective number of individuals under androdioecy and gynodioecy. We analyze dynamic models of autosomal modifiers of weak effect on sex expression. In our zygote control models, the sex expressed by a zygote depends on its own genotype, while in our maternal control models, it depends on the genotype of its maternal parent. Our analysis unifies full multi-dimensional local stability analysis with the Li-Price equation, which for all its heuristic appeal, describes evolutionary change over a single generation...
September 11, 2017: Theoretical Population Biology
https://www.readbyqxmd.com/read/28911537/functional-study-of-cordyceps-sinensis-and-cordycepin-in-male-reproduction-a-review
#19
REVIEW
Yung-Chia Chen, Ying-Hui Chen, Bo-Syong Pan, Ming-Min Chang, Bu-Miin Huang
Cordyceps sinensis has various biological and pharmacological functions, and it has been claimed as a tonic supplement for sexual and reproductive dysfunctions for a long time in oriental society. In this article, the in vitro and in vivo effects of C. sinensis and cordycepin on mouse Leydig cell steroidogenesis are briefly described, the stimulatory mechanisms are summarized, and the recent findings related to the alternative substances regulating male reproductive functions are also discussed.
January 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28911172/androgens-mediate-sex-dependent-gonadotropin-expression-during-late-prenatal-development-in-the-mouse
#20
Michael J Kreisman, Christopher I Song, Kathleen Yip, Bryony V Natale, David R Natale, Kellie M Breen
Central organization of the hypothalamic-pituitary-gonadal axis is initiated during fetal life. At this critical time, gonadal hormones mediate sex-specific development of the hypothalamic-pituitary axis, which then dictates reproductive physiology and behavior in adulthood. Although studies have investigated the effects of prenatal androgens on central factors influencing gonadotropin-releasing hormone (GnRH) release, the impact of fetal androgens on gonadotrope function has been overlooked. In the current study, we demonstrated that gonadotropin gene expression and protein production were robustly elevated in female mice compared with males during late fetal development and that this sex difference was dependent on fetal androgens...
September 1, 2017: Endocrinology
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