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https://www.readbyqxmd.com/read/27909828/the-dopamine-related-polymorphisms-bdnf-comt-drd2-drd3-and-drd4-are-not-linked-with-changes-in-csf-dopamine-levels-and-frequency-of-hiv-infection
#1
Anne Horn, C Scheller, S du Plessis, R Burger, G Arendt, J Joska, S Sopper, C M Maschke, M Obermann, I W Husstedt, J Hain, P Riederer, E Koutsilieri
We showed previously that higher levels in CSF dopamine in HIV patients are associated with the presence of the dopamine transporter (DAT) 10/10-repeat allele which was also detected more frequently in HIV-infected individuals compared to uninfected subjects. In the current study, we investigated further whether other genetic dopamine (DA)-related polymorphisms may be related with changes in CSF DA levels and frequency of HIV infection in HIV-infected subjects. Specifically, we studied genetic polymorphisms of brain-derived neurotrophic factor, catechol-O-methyltransferase, and dopamine receptors DRD2, DRD3, and DRD4 genetic polymorphisms in uninfected and HIV-infected people in two different ethnical groups, a German cohort (Caucasian, 72 individuals with HIV infection and 22 individuals without HIV infection) and a South African cohort (Xhosan, 54 individuals with HIV infection and 19 individuals without HIV infection)...
December 1, 2016: Journal of Neural Transmission
https://www.readbyqxmd.com/read/27903042/prevalence-and-management-of-diabetes-in-residential-aged-care-facilities-in-north-east-victoria-australia
#2
Helen M Haines, Holly Bannon-Murphy, Tim Amos, Robert Krones
BACKGROUND: Managing diabetes in residential aged care facilities (RACFs) presents challenges to general practitioners (GPs) as the incidence of the disease increases. OBJECTIVE: The objective of this article is to describe the prevalence and management of diabetes in RACFs in north-east Victoria. METHODS: The method used for this study was a cross-sectional audit of medical files. RESULTS: Ten RACFs were invited and agreed to participate, giving a sample of 593 residents...
December 2016: Australian Family Physician
https://www.readbyqxmd.com/read/27900214/are-magnetic-resonance-imaging-undetectable-prostate-tumours-clinically-significant-results-of-histopathological-analyses
#3
Kristian D Stensland, Karl Coutinho, Adele R Hobbs, Lindsay Haines, Shemille A Collingwood, Young Suk Kwon, Simon J Hall, Maria Katsigeorgis, Seyed Behzad Jazayeri, David B Samadi
OBJECTIVE: To investigate whether tumours at threshold values for detection on magnetic resonance imaging (MRI) represent clinically significant tumours or not, and therefore the utility of MRI in active surveillance (AS) protocols. PATIENTS AND METHODS: A retrospective analysis of a single institution database was performed after Institutional Review Board approval. Between 2010 and 2013, 1633 patients underwent robot-assisted laparoscopic prostatectomy (RALP) at a single institution by a single surgeon...
December 2016: Arab Journal of Urology
https://www.readbyqxmd.com/read/27897176/correspondence-reply-to-strongly-driven-re-co2-redox-reaction-at-high-pressure-and-high-temperature
#4
Mario Santoro, Federico A Gorelli, Roberto Bini, Ashkan Salamat, Gaston Garbarino, Claire Levelut, Olivier Cambon, Julien Haines
No abstract text is available yet for this article.
November 29, 2016: Nature Communications
https://www.readbyqxmd.com/read/27897154/carbon-enters-silica-forming-a-cristobalite-type-co2-sio2-solid-solution
#5
Mario Santoro, Federico A Gorelli, Roberto Bini, Ashkan Salamat, Gaston Garbarino, Claire Levelut, Olivier Cambon, Julien Haines
No abstract text is available yet for this article.
November 29, 2016: Nature Communications
https://www.readbyqxmd.com/read/27894710/bowel-dysfunction-after-anastomotic-leakage-in-laparoscopic-sphincter-saving-operative-intervention-for-rectal-cancer-a-case-matched-study-in-46-patients-using-the-low-anterior-resection-score
#6
Elisabeth Hain, Gilles Manceau, Léon Maggiori, Cécile Mongin, Justine Prost À la Denise, Yves Panis
BACKGROUND: After sphincter-saving operation for rectal cancer, the impact of anastomotic leakage on function has been well studied. The purpose of the present work was to assess the influence of symptomatic and asymptomatic anastomotic leakage on bowel function and health-related quality of life using the Low Anterior Resection Syndrome score and the disease-specific questionnaire European Organization for Research and Treatment of Quality of Life Questionnaire for Colorectal Cancer...
November 25, 2016: Surgery
https://www.readbyqxmd.com/read/27892998/overall-survival-following-neoadjuvant-chemotherapy-vs-primary-cytoreductive-surgery-in-women-with-epithelial-ovarian-cancer-analysis-of-the-national-cancer-database
#7
J Alejandro Rauh-Hain, Alexander Melamed, Alexi Wright, Allison Gockley, Joel T Clemmer, John O Schorge, Marcela G Del Carmen, Nancy L Keating
Importance: Uncertainty remains about the relative benefits of primary cytoreductive surgery (PCS) vs neoadjuvant chemotherapy (NACT) for advanced-stage epithelial ovarian cancer (EOC). Objective: To compare overall survival of PCS vs NACT in a large national population of women with advanced-stage EOC. Design, Setting, and Participants: Retrospective cohort study of women with stage IIIC and IV EOC diagnosed between 2003 and 2011 treated at hospitals across the United States reporting to the National Cancer Data Base...
November 17, 2016: JAMA Oncology
https://www.readbyqxmd.com/read/27892982/vision-loss-in-a-teenage-girl-with-postconcussion-syndrome
#8
Hasenin Al-Khersan, Tim Hain, Michael A Grassi
No abstract text is available yet for this article.
November 17, 2016: JAMA Ophthalmology
https://www.readbyqxmd.com/read/27892854/a-comprehensive-excitatory-input-map-of-the-striatum-reveals-novel-functional-organization
#9
Barbara J Hunnicutt, Bart C Jongbloets, William T Birdsong, Katrina J Gertz, Haining Zhong, Tianyi Mao
The striatum integrates excitatory inputs from the cortex and the thalamus to control diverse functions. Although the striatum is thought to consist of sensorimotor, associative and limbic domains, their precise demarcations and whether additional functional subdivisions exist remain unclear. How striatal inputs are differentially segregated into each domain is also poorly understood. This study presents a comprehensive map of the excitatory inputs to the mouse striatum. The input patterns reveal boundaries between the known striatal domains...
November 28, 2016: ELife
https://www.readbyqxmd.com/read/27890597/identification-eukaryotic-expression-and-structure-function-characterizations-of-%C3%AE-defensin-like-homologues-from-pelodiscus-sinensis
#10
Haining Yu, Xuelian Liu, Hui Wang, Lan Feng, Xue Qiao, Shasha Cai, Nannan Shi, Yipeng Wang
Defensins are a group of host defense peptides that play a central role in host innate immune responses. Here, 26 genes encoding β-defensin-like peptides have been identified for the first time in Pelodiscus sinensis using database mining approach. Phylogenetic study confirmed that β-defensins are fast evolving genes with high rates of sequence substitutions. The expression level of several selected genes in different tissues was examined by RT-PCR. Ps-BDs mainly adopt β-strands and/or α-helix conformations homology modeled by Rosetta program...
November 24, 2016: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/27888942/lessons-learned-from-two-decades-of-patient-and-family-centered-care-in-radiology-part-2-building-a-culture
#11
James V Rawson, Layne Mitchell, Lewis Golden, Alisa Murdock, G Rebecca Haines
As reimbursements are increasingly linked to patient experience, physicians and hospitals will need to find ways to incorporate patient and family input into operational decisions. Rather than starting from the beginning, health systems could learn from practitioners who have been experimenting in this space and are willing to share their experience. The authors share lessons learned from two decades of experience incorporating patient and family advisers into the clinical operation of a radiology department and the resulting culture change...
December 2016: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/27888941/lessons-learned-from-two-decades-of-patient-and-family-centered-care-in-radiology-part-1-getting-started
#12
James V Rawson, Layne Mitchell, Lewis Golden, Alisa Murdock, G Rebecca Haines
Patient- and family-centered care has a long history, but the application of these principles to radiology is limited by infrequent direct patient contact for many radiologists; scarce peer-reviewed data in the radiology literature; and sparse access to implementation strategies, tools, and best practices. In a series of two articles, the authors share two decades of lessons learned from implementing patient- and family-centered care in a radiology department.
December 2016: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/27886565/investigating-the-relationship-between-reduced-self-awareness-of-falls-risk-rehabilitation-engagement-and-falls-in-older-adults
#13
Tijana Mihaljcic, Terry P Haines, Jennie L Ponsford, Renerus J Stolwyk
The present study aimed to investigate whether self-awareness of falls risk is associated with rehabilitation engagement, motivation for rehabilitation, and number of falls after hospital discharge. The sample comprised 91 older adults (Mage=77.97, SD=8.04) undergoing inpatient rehabilitation. The Self-Awareness of Falls Risk Measure (SAFRM) was used to measure different aspects of self-awareness. The treating physiotherapist and occupational therapist rated the patient's engagement in rehabilitation and the patient reported his/her motivation for treatment...
November 16, 2016: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/27885565/analysis-of-bacterial-fungal-and-archaeal-populations-from-a-municipal-wastewater-treatment-plant-developing-an-innovative-aerobic-granular-sludge-process
#14
Jun Liu, Jun Li, Yaqiang Tao, Balasubramanian Sellamuthu, Ryan Walsh
Mature granules and flocs from aerobic sludge were collected from the wastewater treatment plant (WWTP) treating both municipal and industrial effluents in Haining city China. This plant has been operating under conditions favoring aerobic granular sludge formation, for over 3 years, suggesting that the granules, which stably retained under changing effluent conditions, may contain unique microbial populations. Microbial analysis indicated that the granular sludge was primarily composed of Planctomycetes, Proteobacteria and Bacteroidetes from the bacterial phyla...
January 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/27883365/educational-interventions-for-the-management-of-cancer-related-fatigue-in-adults
#15
REVIEW
Sally Bennett, Amanda Pigott, Elaine M Beller, Terry Haines, Pamela Meredith, Christie Delaney
BACKGROUND: Cancer-related fatigue is reported as the most common and distressing symptom experienced by patients with cancer. It can exacerbate the experience of other symptoms, negatively affect mood, interfere with the ability to carry out everyday activities, and negatively impact on quality of life. Educational interventions may help people to manage this fatigue or to cope with this symptom, and reduce its overall burden. Despite the importance of education for managing cancer-related fatigue there are currently no systematic reviews examining this approach...
November 24, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27882569/selective-reduction-in-the-expression-of-ugts-and-sults-a-novel-mechanism-by-which-piperine-enhances-the-bioavailability-of-curcumin-in-rat
#16
Xiaohui Zeng, Dake Cai, Qiaohuang Zeng, Zhao Chen, Guoping Zhong, Juncheng Zhuo, Haining Gan, Xuejun Huang, Ziming Zhao, Nan Yao, Dane Huang, Chengzhe Zhang, Dongmei Sun, Yuxing Chen
Curcumin (CUR) is known to exert numerous health-promoting effects in pharmacological studies, but its low-bioavailability hinders the development of CUR as a feasible therapeutic agent. Piperine (PIP) has been reported to enhance the bioavailability of CUR, but the underlying mechanism remains poorly understood. In an attempt to find the mechanism by which PIP enhances the bioavailability of CUR, dosage ratio (CUR: PIP) and PIP pre-treatment are hypothesized as key factors for bioavailability improvement in this combination...
November 23, 2016: Biopharmaceutics & Drug Disposition
https://www.readbyqxmd.com/read/27871320/assessment-of-the-dimensionality-of-the-wijma-delivery-expectancy-experience-questionnaire-using-factor-analysis-and-rasch-analysis
#17
J F Pallant, H M Haines, P Green, J Toohill, J Gamble, D K Creedy, J Fenwick
BACKGROUND: Fear of childbirth has negative consequences for a woman's physical and emotional wellbeing. The most commonly used measurement tool for childbirth fear is the Wijma Delivery Expectancy Questionnaire (WDEQ-A). Although originally conceptualized as unidimensional, subsequent investigations have suggested it is multidimensional. This study aimed to undertake a detailed psychometric assessment of the WDEQ-A; exploring the dimensionality and identifying possible subscales that may have clinical and research utility...
November 21, 2016: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/27866127/prevention-of-coronary-microvascular-plugging-the-next-target-in-stemi
#18
Christiaan J M Vrints, Steven E F Haine
No abstract text is available yet for this article.
November 20, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27865383/analytical-and-clinical-performance-characteristics-of-the-abbott-realtime-mtb-rif-inh-resistance-an-assay-for-the-detection-of-rifampicin-and-isoniazid-resistant-mycobacterium-tuberculosis-in-pulmonary-specimens
#19
Joshua Kostera, Gregor Leckie, Ning Tang, John Lampinen, Magdalena Szostak, Klara Abravaya, Hong Wang
Clinical management of drug-resistant tuberculosis patients continues to present significant challenges to global health. To tackle these challenges, the Abbott RealTime MTB RIF/INH Resistance assay was developed to accelerate the diagnosis of rifampicin and/or isoniazid resistant tuberculosis to within a day. This article summarizes the performance of the Abbott RealTime MTB RIF/INH Resistance assay; including reliability, analytical sensitivity, and clinical sensitivity/specificity as compared to Cepheid GeneXpert MTB/RIF version 1...
December 2016: Tuberculosis
https://www.readbyqxmd.com/read/27865235/role-of-real-time-pcr-for-detection-of-tuberculosis-and-drug-resistance-directly-from-clinical-samples
#20
Parashuram Rao, Kiran Chawla, Vishnu Prasad Shenoy, Chiranjay Mukhopadhyay
BACKGROUND: Only a few studies done earlier in India reveal the utility of real-time PCR in detecting drug resistance in cases of pulmonary tuberculosis. OBJECTIVES: The study was carried out to standardise real-time PCR (Quantitative real-time PCR, qPCR) targeting 16s RNA for the rapid detection of tuberculosis and its drug resistance from suspected TB patients. MATERIALS AND METHODS: Sputum samples from 100 clinically suspected tuberculosis patients, after processing were subjected to microscopy, MGIT culture and qPCR...
July 2016: Indian Journal of Tuberculosis
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