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JOURNAL ARTICLE
Diego Josa Montero, Gisell Bustos Moya, Soad Amira Yusef, Stephanie Crevoisier, Edwin Silva, Natalia López, Rafael Leal, Isabel Torres Molina, Juan Pablo Osorio, Gerson Arias, Fabián Cortés-Muñoz, Carolina Sánchez, Luis Felipe Reyes
BACKGROUND: Early and adequate antibiotic treatment is the cornerstone of improving clinical outcomes in patients with bloodstream infections (BSI). Delays in appropriate antimicrobial therapy have catastrophic consequences for patients with BSI. Microbiological characterization of multi-drug resistant pathogens (MDRP) allows clinicians to provide appropriate treatments. Current microbiologic techniques may take up to 96 h to identify causative pathogens and their resistant patterns. Therefore, there is an important need to develop rapid diagnostic strategies for MDRP...
December 26, 2022: Antibiotics
#22
JOURNAL ARTICLE
Min Yi, Bin Zhuo, Freda Cooner
Oncology/hematology is a competitive therapeutic area where the landscape is constantly evolving. With regulatory support, many drug developers have spent a lot of resources on the operationalization of innovative clinical trial designs, for example, adaptive Bayesian designs in confirmatory clinical trial settings. While overall survival is considered the gold standard in these designs, it is often not a viable choice in identifying treatment efficacy at a reasonable pace, especially for early-stage therapies...
January 18, 2023: Journal of Biopharmaceutical Statistics
#23
JOURNAL ARTICLE
Leandro Moreira Peres, Fabio Luis-Silva, Mayra Gonçalves Menegueti, Lucas Sato, Anibal Basile-Filho, Vivian Marques Miguel Suen, Olindo Assis Martins-Filho, Maria Auxiliadora-Martins
INTRODUCTION: Therapy and nutritional status directly interfere in the clinical evolution of critically ill patients, in reducing morbidity and mortality, by maintaining the functional integrity of the gastrointestinal tract, decreasing the catabolic response, besides contributing to the reduction of hospitalization time resulting in less treatment cost. Critical patients and trauma victims suffer early changes in the quantity and quality of muscle mass. Tools to identify the groups most susceptible to these complications are necessary so that interventions can minimize the deleterious effects of malnutrition in critically ill patients...
December 2, 2022: Medicine (Baltimore)
#24
REVIEW
Elena A Egorova, Maxim P Nikitin
Active targeting of tumors is believed to be the key to efficient cancer therapy and accurate, early-stage diagnostics. Active targeting implies minimized off-targeting and associated cytotoxicity towards healthy tissue. One way to acquire active targeting is to employ conjugates of therapeutic agents with ligands known to bind receptors overexpressed onto cancer cells. The integrin receptor family has been studied as a target for cancer treatment for almost fifty years. However, systematic knowledge on their effects on cancer cells, is yet lacking, especially when utilized as an active targeting ligand for particulate formulations...
November 8, 2022: International Journal of Molecular Sciences
#25
REVIEW
Rachel Teh, Ali Azimi, Gulietta M Pupo, Marina Ali, Graham J Mann, Pablo Fernández-Peñas
Overdiagnosis of early melanoma is a significant problem. Due to subtle unique and overlapping clinical and histological criteria between pigmented lesions and the risk of mortality from melanoma, some benign pigmented lesions are diagnosed as melanoma. Although histopathology is the gold standard to diagnose melanoma, there is a demand to find alternatives that are more accurate and cost-effective. In the current "omics" era, there is gaining interest in biomarkers to help diagnose melanoma early and to further understand the mechanisms driving tumour progression...
November 14, 2022: Experimental Dermatology
#26
JOURNAL ARTICLE
Maureen J Miller, Shama Cash-Goldwasser, Grace E Marx, Caroline A Schrodt, Anne Kimball, Kia Padgett, Rebecca S Noe, David W McCormick, Joshua M Wong, Sarah M Labuda, Brian F Borah, Isaac Zulu, Amimah Asif, Gurpreet Kaur, Janet M McNicholl, Athena Kourtis, Andrew Tadros, Sarah Reagan-Steiner, Jana M Ritter, Yon Yu, Patricia Yu, Rachel Clinton, Corrine Parker, Eleanor S Click, Johanna S Salzer, Andrea M McCollum, Brett Petersen, Faisal S Minhaj, Ericka Brown, Michael P Fischer, Robert L Atmar, Andrew R DiNardo, Ya Xu, Cameron Brown, Jerry Clay Goodman, Ashley Holloman, Julia Gallardo, Hanna Siatecka, Georgia Huffman, John Powell, Philip Alapat, Pralay Sarkar, Nicola A Hanania, Or Bruck, Steven D Brass, Aneesh Mehta, Alexandra W Dretler, Amanda Feldpausch, Jessica Pavlick, Hillary Spencer, Isaac Ghinai, Stephanie R Black, Laura N Hernandez-Guarin, Sarah Y Won, Shivanjali Shankaran, Andrew T Simms, Jemma Alarcón, Jesse G O'Shea, John T Brooks, Jennifer McQuiston, Margaret A Honein, Siobhán M O'Connor, Kevin Chatham-Stephens, Kevin O'Laughlin, Agam K Rao, Elliot Raizes, Jeremy A W Gold, Sapna Bamrah Morris
As of October 21, 2022, a total of 27,884 monkeypox cases (confirmed and probable) have been reported in the United States.§ Gay, bisexual, and other men who have sex with men have constituted a majority of cases, and persons with HIV infection and those from racial and ethnic minority groups have been disproportionately affected (1,2). During previous monkeypox outbreaks, severe manifestations of disease and poor outcomes have been reported among persons with HIV infection, particularly those with AIDS (3-5)...
November 4, 2022: MMWR. Morbidity and Mortality Weekly Report
#27
JOURNAL ARTICLE
Anna Maria Peri, Weiping Ling, Luis Furuya-Kanamori, Patrick N A Harris, David L Paterson
BACKGROUND: Early identification of bloodstream pathogens and their associated antimicrobial resistance may shorten time to optimal therapy in patients with sepsis. The BioFire Blood Culture Identification 2 Panel (BCID2) is a novel multiplex PCR detecting 43 targets directly from positive blood cultures, reducing turnaround times. METHODS: We have performed a systematic review and meta-analysis of diagnostic test accuracy studies to assess the BCID2 performance for pathogen identification and resistance markers detection compared to gold standard culture-based methods (including phenotypic and/or genotypic characterization)...
October 20, 2022: BMC Infectious Diseases
#28
REVIEW
Zaria Malindi, Stefan Barth, Heidi Abrahamse
Melanoma is highly aggressive and is known to be efficient at resisting drug-induced apoptotic signals. Resection is currently the gold standard for melanoma management, but it only offers local control of the early stage of the disease. Metastatic melanoma is prone to recurrence, and has a poor prognosis and treatment response. Thus, the need for advanced theranostic alternatives is evident. Photodynamic therapy has been increasingly studied for melanoma treatment; however, it relies on passive drug accumulation, leading to off-target effects...
September 1, 2022: Biomedicines
#29
JOURNAL ARTICLE
Simon Faissner, Neele Heitmann, Carlos Plaza-Sirvent, Paulina Trendelenburg, Ulas Ceylan, Jeremias Motte, Clara Bessen, Doris Urlaub, Carsten Watzl, Oliver Overheu, Anke Reinacher-Schick, Kerstin Hellwig, Stephanie Pfaender, Ingo Schmitz, Ralf Gold
Objective: The pandemic induced by SARS-CoV-2 has huge implications for patients with immunosuppression that is caused by disorders or specific treatments. Especially approaches targeting B cells via anti-CD20 therapy are associated with impaired humoral immune response but sustained cellular immunity. Ofatumumab is a human anti-CD20 directed antibody applied in low dosages subcutaneously, recently licensed for Multiple Sclerosis (MS). Effects of early ofatumumab treatment on alterations of immune cell composition and immune response towards SARS-CoV-2 are incompletely understood...
2022: Frontiers in Immunology
#30
JOURNAL ARTICLE
Shi-Jie Liu, Ke Ma, Long-Shan Liu, Ke Wang, Ying-Ao Zhang, Zi-Rong Bi, Yan-Xu Chen, Ke-Zheng Chen, Chang-Xi Wang, Sheng-Lin Qiao
Accurate and non-invasive monitoring of allograft posttransplant is essential for early detection of acute cellular rejection and determines the long-term survival of the graft. Clinically, tissue biopsy is the most effective approach for diagnosing transplant rejection. Nonetheless, the procedure is invasive and potentially triggers organ failure. This work aims to design and apply GzmB-responsive nanosensors (GBRNs) that can readily size-change in graft tissues. Subsequently, we investigate the activity of serine protease granzyme B by generating a direct colorimetric urinary readout for non-invasive detection of transplant rejection in under 1 h...
July 13, 2022: Biosensors & Bioelectronics
#31
REVIEW
Andrea M Guida, Bruno Sensi, Vincenzo Formica, Rolando M D'Angelillo, Mario Roselli, Giovanna Del Vecchio Blanco, Piero Rossi, Gabriella T Capolupo, Marco Caricato, Giuseppe S Sica
Colorectal carcinoma is the second leading cause of cancer-related deaths, and indeed, rectal cancer accounting for approximately one third of newly diagnosed patients. Gold standard in the treatment of rectal cancer is a multimodality approach, aiming at a good control of the local disease. Distant recurrences are the major cause of mortality. Currently, Locally Advanced Rectal Cancer (LARC) patients undergo a combined treatment of chemotherapy and radiotherapy, followed by surgery. Eventually, more chemotherapy, namely adjuvant chemotherapy (aCT), may be necessary...
June 13, 2022: Biology Direct
#32
JOURNAL ARTICLE
Ryohei Yamauchi, Natsuki Murayoshi, Shinobu Akiyama, Norifumi Mizuno, Tomoyuki Masuda, Tomoko Itazawa, Jiro Kawamori
External beam accelerated partial breast irradiation (APBI) is an alternative treatment for patients with early-stage breast cancer. The efficacy of image-guided radiotherapy (IGRT) using fiducial markers, such as gold markers or surgical clips, has been demonstrated. However, the effects of respiratory motion during a single fraction have not been reported. This study aimed to evaluate the residual image registration error of fiducial marker-based IGRT by respiratory motion and propose a suitable treatment strategy...
September 2022: Physical and engineering sciences in medicine
#33
Heloísa Ferreira Pinto Santos, Lusiele Guaraldo, Renata Saraiva Pedro, Luana Santana Damasceno, Cláudio Tadeu Daniel-Ribeiro, Patrícia Brasil
Malaria is a curable disease for which early diagnosis and treatment, together with the elimination of vectors, are the principal control tools. Non-adherence to antimalarial treatment may contribute to therapeutic failure, development of antimalarial resistance, introduction or resurgence of malaria in non-endemic areas, and increased healthcare costs. The literature describes several methods to directly or indirectly assess adherence to treatment, but no gold standard exists. The main purpose of this review is to systematize the methods used to assess patient adherence to antimalarial treatment...
2022: Frontiers in Pharmacology
#34
JOURNAL ARTICLE
Sergio Ferra-Murcia, Antonio Ramón Collado-Romacho, Bruno José Nievas-Soriano, Fernando Reche-Lorite, Tesifón Parrón-Carreño
Treatment with interferon-free direct-acting antivirals (DAA) has become the gold standard in chronic hepatitis C virus (HCV) infection. Nevertheless, little research about the metabolic impact of achieving sustained virological response (SVR) is available in HCV/HIV co-infected patients. This research aimed to evaluate early anthropometric, lipid and liver parameters changes after achieving SVR 12 weeks after treatment (SVR12). A real-life retrospective descriptive before-after study assessed 128 DAA treatment episodes from 2015 to 2019 in HCV/HIV co-infected patients...
May 7, 2022: Journal of Clinical Medicine
#35
REVIEW
Monika Geretsegger, Laura Fusar-Poli, Cochavit Elefant, Karin A Mössler, Giovanni Vitale, Christian Gold
BACKGROUND: Social interaction and social communication are among the central areas of difficulty for autistic people. Music therapy uses music experiences and the relationships that develop through them to enable communication and expression, thus attempting to address some of the core problems of autistic people. Music therapy has been applied in autism since the early 1950s, but its availability to autistic individuals varies across countries and settings. The application of music therapy requires specialised academic and clinical training which enables therapists to tailor the intervention to the specific needs of the individual...
May 9, 2022: Cochrane Database of Systematic Reviews
#36
JOURNAL ARTICLE
Sonal Mistry, Anup Das, Sina Saffaran, Nadir Yehya, Timothy E Scott, Marc Chikhani, John G Laffey, Jonathan G Hardman, Luigi Camporota, Declan G Bates
BACKGROUND: Airway pressure release ventilation (APRV) is widely available on mechanical ventilators and has been proposed as an early intervention to prevent lung injury or as a rescue therapy in the management of refractory hypoxemia. Driving pressure ([Formula: see text]) has been identified in numerous studies as a key indicator of ventilator-induced-lung-injury that needs to be carefully controlled. [Formula: see text] delivered by the ventilator in APRV is not directly measurable in dynamic conditions, and there is no "gold standard" method for its estimation...
April 26, 2022: Respiratory Research
#37
JOURNAL ARTICLE
Menna Hashish, Mohamed Reda Bassiouny
Seizures are the most common neurological disorders in newborns. Managing neonatal seizures is challenging, especially for neurologists who are not neonatal specialists. Acute brain injury during ischemic insult is a key component of seizure occurrence, while genetic and metabolic disorders play less prevalent but more severe roles. The diagnosis of neonatal seizure is ambiguous, as the subjective differentiation between seizure and nonepileptic events is difficult; therefore, electrographic recording is the gold standard for diagnosis...
November 2022: Clinical and experimental pediatrics
#38
JOURNAL ARTICLE
Lei Chen, Yin Sun, Min Tang, Denglong Wu, Zhendong Xiang, Chi-Ping Huang, Bosen You, Dongdong Xie, Qinglin Ye, Dexin Yu, Chawnshang Chang
Androgen deprivation therapy (ADT) is a gold standard treatment for advanced PCa. However, most patients eventually develop the castration-resistant prostate cancer (CRPC) that progresses rapidly despite ongoing systemic androgen deprivation. While early studies indicated that high physiological doses of androgens might suppress rather than promote PCa cell growth in some selective CRPC patients, the exact mechanism of this opposite effect remains unclear. Here we found that Enzalutamide-resistant (EnzR) CRPC cells can be suppressed by the high-dose-androgen (dihydrotestosterone, DHT)...
March 22, 2022: Cell Death Discovery
#39
JOURNAL ARTICLE
Robert S Wallis, Sibuse Ginindza, Trevor Beattie, Nishanee Arjun, Morongwe Likoti, Modulakgotla Sebe, Vinodh A Edward, Mohammed Rassool, Khatija Ahmed, Katherine Fielding, Bintou A Ahidjo, Mboyo D T Vangu, Gavin Churchyard
BACKGROUND: Current tuberculosis treatments leave most patients with bronchiectasis and fibrosis, permanent conditions that impair lung function and increase all-cause post-TB mortality. Host-directed therapies (HDTs) may reduce lung inflammation and hasten eradication of infection. Biomarkers can accelerate tuberculosis regimen development, but no studies have yet examined early biomarkers of TB-HDTs. METHODS: Biomarkers of inflammation and microbicidal activity were evaluated as a part of a recent phase-2 randomized controlled trial of four HDTs in 200 patients with pulmonary tuberculosis and baseline predictors of poor outcome, including CC-11050 (PDE4i), everolimus (mTORi), auranofin (oral gold salt), and ergocalciferol (vitamin D)...
2022: PloS One
#40
REVIEW
Yolanda Piña, Sirisha Yadugiri, Debra N Yeboa, Sherise D Ferguson, Peter A Forsyth, Isabella C Glitza Oliva
PURPOSE OF REVIEW: Melanoma has one of the highest incidences of causing leptomeningeal disease (LMD) among solid tumors. LMD patients have very poor prognosis with a dismal survival despite aggressive management. In this article, we review the current approaches in the management of patients with LMD secondary to melanoma, including updates in diagnosis, treatment, up-to-date clinical studies, and future directions. RECENT FINDINGS: Cerebrospinal fluid (CSF) cytology remains the gold standard for diagnosis, and alternatively, MRI based on clinical presentation can be used...
January 2022: Current Oncology Reports
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