keyword
MENU ▼
Read by QxMD icon Read
search

oncopathology

keyword
https://www.readbyqxmd.com/read/27869446/-oncopathological-aspects-of-brca1-and-brca2-genes-inactivation-in-tumors-of-ovary-fallopian-tube-and-pelvic-peritoneum
#1
Petr Škapa, Pavel Dundr
Ovarian carcinoma represents a heterogeneous group of malignant epithelial tumors which could be divided into two fundamental groups: Type I (endometrioid carcinoma, clear cell carcinoma, low grade serous carcinoma, mucinous carcinoma and more rare seromucinous carcinoma and malignant Brenner tumor) and type II (high grade serous carcinoma - HGSC). HGSC is the most frequent ovarian carcinoma which may be etiologically linked to inactivation of tumor suppressor genes BRCA1/2 and TP53 and differs from type I carcinomas by higher aggressiveness, tendency to peritoneal spread and worse prognosis...
2016: Ceskoslovenská Patologie
https://www.readbyqxmd.com/read/26980676/stimulator-of-interferon-genes-sting-a-new-chapter-in-virus-associated-cancer-research-lessons-from-wild-derived-mouse-models-of-innate-immunity
#2
Alexander Poltorak, Olga Kurmyshkina, Tatyana Volkova
Thanks to the numerous studies that have been carried out recently in the field of cytosolic DNA sensing, STING (Stimulator of Interferon Genes) is now recognized as a key mediator of innate immune signaling. A substantial body of evidence derived from in vivo mouse models demonstrates that STING-regulated pathways underlie the pathogenesis of many diseases including infectious diseases and cancers. It has also become evident from these studies that STING is a promising therapeutic target for the treatment of cancer...
March 4, 2016: Cytokine & Growth Factor Reviews
https://www.readbyqxmd.com/read/26925646/disorder-of-endothelia-vessels-functional-state-with-malignant-tumors-in-patients-exposed-anthropogenic-radiation
#3
Laura Pak, Yoshihiro Noso, Nailya Chaizhunusova, Zukhra Anambaeva, Tasbolat Adylkhanov, Nobuo Takeichi, Sayakhat Lzhaev, Daniyar Aldyngurov, Raikhan Tuleutayeva, Ainur Argynbekova, Gulyash Tanysheva, Lashyn Zhazykbayeva, Ainur Baissalbayeva, Tolebay Rakhypbekov
The aim of this research is to determine the characteristics of endothelial factors and the hemostatic system conditions with malignant neoplasms patients, which were exposed to ionizing radiation. Total number of examined people is 223, 153 of them are patients with gastrointestinal tract oncopathology. The article presents the results of the analysis of numerical indicators of endothelial condition and platelet hemostasis of patients, who had cancer. They lived in the regions of Kazakhstan, subjected to contamination of radionuclides as a result of nuclear weapons tests, which took place in this region from 1949 to 1989...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/26885534/monocyte-activation-in-immunopathology-cellular-test-for-development-of-diagnostics-and-therapy
#4
REVIEW
Ekaterina A Ivanova, Alexander N Orekhov
Several highly prevalent human diseases are associated with immunopathology. Alterations in the immune system are found in such life-threatening disorders as cancer and atherosclerosis. Monocyte activation followed by macrophage polarization is an important step in normal immune response to pathogens and other relevant stimuli. Depending on the nature of the activation signal, macrophages can acquire pro- or anti-inflammatory phenotypes that are characterized by the expression of distinct patterns of secreted cytokines and surface antigens...
2016: Journal of Immunology Research
https://www.readbyqxmd.com/read/26350744/-oxidative-stress-in-platelets-at-an-oncopathology
#5
E G Gorozhanskaya, S P Sviridova, V N Baykova, G N Zubrikhina, M M Dobrovolskaya, A V Sitov
To determine the biochemical disorders in the blood coagulation mechanism associated with oxidative stress parameters of the antioxidant status were examined in platelets of 57 colorectal cancer patients, (including 21 patients before and after surgery), and 40 healthy individuals. We determined the total content of nitric oxide (NOx), levels of superoxide dismutase (Cu/ZnSOD), glutathione and malondialdehyde (MDA). Before treatment, we observed the changes in the antioxidant defense system of platelets, which did not depend on the prevalence of malignancy: elevated levels of SOD by 16% (p<0...
July 2015: Biomedit︠s︡inskai︠a︡ Khimii︠a︡
https://www.readbyqxmd.com/read/26107190/-drawing-a-molecular-portrait-of-cin-and-cervical-cancer-a-review-of-genome-wide-molecular-profiling-data
#6
REVIEW
Olga V Kurmyshkina, Pavel I Kovchur, Tatyana O Volkova
In this review we summarize the results of studies employing high-throughput methods of profiling of HPV-associated cervical intraepithelial neoplasia (CIN) and squamous cell cervical cancers at key intracellular regulatory levels to demonstrate the unique identity of the landscape of molecular changes underlying this oncopathology, and to show how these changes are related to the 'natural history' of cervical cancer progression and the formation of clinically significant properties of tumors. A step-wise character of cervical cancer progression is a morphologically well-described fact and, as evidenced by genome-wide screenings, it is indeed the consistent change of the molecular profiles of HPV-infected epithelial cells through which they progressively acquire the phenotypic hallmarks of cancerous cells...
2015: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/25209392/performance-of-amplicon-based-next-generation-dna-sequencing-for-diagnostic-gene-mutation-profiling-in-oncopathology
#7
Daoud Sie, Peter J F Snijders, Gerrit A Meijer, Marije W Doeleman, Marinda I H van Moorsel, Hendrik F van Essen, Paul P Eijk, Katrien Grünberg, Nicole C T van Grieken, Erik Thunnissen, Henk M Verheul, Egbert F Smit, Bauke Ylstra, Daniëlle A M Heideman
PURPOSE: Next generation DNA sequencing (NGS) holds promise for diagnostic applications, yet implementation in routine molecular pathology practice requires performance evaluation on DNA derived from routine formalin-fixed paraffin-embedded (FFPE) tissue specimens. The current study presents a comprehensive analysis of TruSeq Amplicon Cancer Panel-based NGS using a MiSeq Personal sequencer (TSACP-MiSeq-NGS) for somatic mutation profiling. METHODS: TSACP-MiSeq-NGS (testing 212 hotspot mutation amplicons of 48 genes) and a data analysis pipeline were evaluated in a retrospective learning/test set approach (n = 58/n = 45 FFPE-tumor DNA samples) against 'gold standard' high-resolution-melting (HRM)-sequencing for the genes KRAS, EGFR, BRAF and PIK3CA...
October 2014: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/23479951/-contemporary-aspects-of-maintenance-and-promotion-of-health-of-the-workers-employed-at-the-aluminum-production-enterprises
#8
N F Izmerov, I V Bukhtiiarov, L V Prokopenko, L P Kuz'mina, N S Sorkina, T B Burmistrova, G N Lagutina
The exposure of the combined occupational hazards on the workers of aluminum plants results in the development of the occupational chronic diseases of bronchopulmonary and bone systems and oncopathology. Pathogenetic mechanisms of the toxic exposure of fluorides on the body as well as molecular and cellular structures are presented.
2012: Meditsina Truda i Promyshlennaia Ekologiia
https://www.readbyqxmd.com/read/23285748/-radiation-induced-modification-of-human-somatic-cell-chromosome-sensitivity-to-the-testing-mutagenic-exposure-of-bleomycin-in-vitro-in-lung-cancer-patients-in-delayed-terms-following-chernobyl-accident
#9
M A Pilinskaia, S S Dybskiĭ, E B Dybskaia, L I Shvaĭko
By using modified "G2-bleomycin sensitivity assay" above background level of cytogenetic effect considered as a marker of hidden chromosome instability (HCI) has been investigated in 3 groups--liquidators of Chernobyl accident (occupational group 1), patients with lung cancer who denied conscious contact--with ionizing radiation (group of comparison), liquidators with lung cancer (occupational group 2). Significant interindividual variations of cytogenetic effects induced with bleomycin and the lack of positive correlation between background and above background frequencies of chromosome aberrations have been shown in all observed groups...
November 2012: T︠S︡itologii︠a︡ i Genetika
https://www.readbyqxmd.com/read/22406782/concordance-between-local-institutional-and-central-pathology-review-in-glioblastoma-implications-for-research-and-practice-a-pilot-study
#10
MULTICENTER STUDY
Tejpal Gupta, Vimoj Nair, Sridhar Epari, Torsten Pietsch, Rakesh Jalali
BACKGROUND: There is significant inter-observer variation amongst the neuro-pathologists in the typing, subtyping, and grading of glial neoplasms for diagnosis. Centralized pathology review has been proposed to minimize this inter-observer variation and is now almost mandatory for accrual into multicentric trials. We sought to assess the concordance between neuro-pathologists on histopathological diagnosis of glioblastoma. MATERIALS AND METHODS: Comparison of local, institutional, and central neuro-oncopathology reporting in a cohort of 34 patients with newly diagnosed supratentorial glioblastoma accrued consecutively at a tertiary-care institution on a prospective trial testing the addition of a new agent to standard chemo-radiation regimen...
January 2012: Neurology India
https://www.readbyqxmd.com/read/21887926/quantitative-molecular-analysis-in-mantle-cell-lymphoma
#11
REVIEW
H Brízová, I Hilská, M Mrhalová, R Kodet
A molecular analysis has three major roles in modern oncopathology--as an aid in the differential diagnosis, in molecular monitoring of diseases, and in estimation of the potential prognosis. In this report we review the application of the molecular analysis in a group of patients with mantle cell lymphoma (MCL). We demonstrate that detection of the cyclin D1 mRNA level is a molecular marker in 98% of patients with MCL. Cyclin D1 quantitative monitoring is specific and sensitive for the differential diagnosis and for the molecular monitoring of the disease in the bone marrow...
July 2011: Ceskoslovenská Patologie
https://www.readbyqxmd.com/read/21634118/-arf6-rala-and-birc5-protein-expression-in-non-small-cell-lung-cancer
#12
A V Knizhnik, O B Kovaleva, K K Laktionov, V V Mochal'nikova, A V Komel'kov, E M Chevkina, I B Zborovskaia
Evaluation of tumor markers expression pattern which determines individual progression parameters is one of the major topics in molecular oncopathology research. This work presents research on expression analysis of several Ras-Ral associated signal transduction pathway proteins (Arf6, RalA and BIRC5) in accordance with clinical criteria in non small cell lung cancer patients. Using Western-blot analysis and RT-PCR Arf6, RalA and BIRC5 expression has been analyzed in parallel in 53 non small cell lung cancer samples of different origin...
March 2011: Molekuliarnaia Biologiia
https://www.readbyqxmd.com/read/21510078/-age-diseases-depending-on-geomagnetic-field-activity-inside-the-womb-period
#13
V A Iamshanov
Between age diseases two are standing out: oncological and cardiovascular ones. They give a main contribution to mortality of the population. Those who avoid these diseases have a chance to live longer. The author suggests a hypothesis of one common factor, which deviation leads to oncology or cardiovascular illness. Such factor is a production of nitric oxide in the organism, which depends on the geomagnetic activity (GMA). At excess production of nitric oxide the risk of oncopathology (breast cancer, bladder and lung cancer and others) is increased...
2010: Advances in Gerontology, Uspekhi Gerontologii
https://www.readbyqxmd.com/read/21395132/-role-of-polymeric-nitric-oxide-in-oncopathology
#14
V A Iamshanov
No abstract text is available yet for this article.
2010: Voprosy Onkologii
https://www.readbyqxmd.com/read/20387655/-oncogenes-ret-ptc-and-mechanisms-of-their-involvement-in-thyroid-cancerogenesis
#15
REVIEW
L H Voskoboĭnyk
Papillary thyroid carcinomas are the most common type of thyroid oncopathology, and are rather often associated with the expression of RET/PTC oncogens. The first oncogen RET/PTC1 was isolated more than 20 years ago. Now 13 different forms of RET/PTC are known, and 12 different partner-genes are described, that could be involved in formation of RET/PTC oncogenes. The most common of them are RET/PTC1 and RET/PTC3 forms. The great majority of oncogens RET/PTC, except for two--ELKS-RET and HOOK3-RET, have been founded in radioaction-induced thyroid tumors...
November 2009: Ukraïnsʹkyĭ Biokhimichnyĭ Z︠h︡urnal
https://www.readbyqxmd.com/read/20101793/-diagnostic-value-of-cardiac-troponin-t-increase-in-critically-ill-patients
#16
E V Koshkina, M Ia Krasnosel'skiĭ, N M Fedorovskiĭ, E V Goriacheva, A A Polupan, A A Aref'ev, A G Katrukha
There are presently reports on elevated levels of cardiac troponins in patients without acute myocardial infarction (AMI). The objective of this investigation was to study the diagnostic value of increased blood cardiac troponin T levels in patients without its clinical picture and ECG changes characteristic of AMI. The study covered 72 patients (48 males and 24 females) aged 54 to 87 years (mean 69.8 +/- 11.2 years). The inclusion criteria were increased cardiac troponin T; the main exclusion criteria were AMI-typical anginal pain and characteristic ECG changes (ST-segment elevation, the appearance of pathological Q waves)...
November 2009: Anesteziologiia i Reanimatologiia
https://www.readbyqxmd.com/read/18652022/-the-sociological-study-of-the-nonresident-patients
#17
COMPARATIVE STUDY
V O Shchepin, Iu K Larionov, I A Gekht
The study of opinions of the patients dwelling in the various regions of the Russian Federation concerning their treatment in the curative preventive institutions of Samarskaya Oblast. Among nonresident patients 52% had an opportunity to pay for additional medical services in the medical institutions of Samarskaya Oblast. This fact testify that among population of neighboring regions the solvent demand of certain kinds of medical care is formed. The patients from neighboring and distant regions much more actively use the free market niches of medical and hospital services...
January 2008: Problemy Sot︠s︡ialʹnoĭ Gigieny, Zdravookhranenii︠a︡ i Istorii Medit︠s︡iny
https://www.readbyqxmd.com/read/18422029/exaggerated-thyroid-stimulating-hormone-secretion-in-children-exposed-to-the-chernobyl-nuclear-reactor-catastrophe
#18
O Y Boyarskaya, O V Kopilova
We present results of a long-term study of the morpho-functional state of the thyroid gland and of the functional capacities of the hypothalamic-hypophyseal system, as shown by thyrotropin releasing hormone stimulation, in different groups of children who suffered from the Chernobyl accident. It was shown that the thyroid gland of the children who were evacuated from the 30-km zone was damaged most severely due to the influence of radioactive iodine (131I). Living on radionuclide-polluted territories in conditions of iodine deficiency has been an additional contributory factor in the development of thyroid gland diseases...
February 2008: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/18208745/-open-and-laparoscopic-transhiatal-oesophagectomy-for-cancer-of-the-oesophagus-analysis-of-resection-margins-and-lymph-nodes
#19
COMPARATIVE STUDY
Víctor Valentí, Sally Fares, Rally Fares, Neal Reynolds, Patricia Cohen, Nick Theodoro, Alberto Martínez-Isla
INTRODUCTION: Surgical treatment of cancer of the oesophagus is associated with a high morbidity and mortality. Minimally invasive surgery has been proposed as an alternative to try to reduce these complications; however, at this time there are not many studies that evaluate the oncological validity of this method. The objective of this work is to give a preliminary audit of the results of our experience in both surgical techniques, with special emphasis on the oncopathological aspects (resection margins and lymph nodes)...
January 2008: Cirugía Española
https://www.readbyqxmd.com/read/17663172/-geomagnetic-field-variations-in-the-human-prenatal-period-and-cancer-in-adults
#20
V A Iamshanov
Our earlier evidence pointed to a relationship between geomagnetic field (GMF) variations in pre- and early postnatal periods and appearance in the future of oncopathology in these patients. It appears to contribute to risk for such malignancies in adults as breast, lung, liver, bladder, kidney, prostate, hypophysis cancer, ovarian carcinoma, skin melanoma, Hodgkin's disease, lymphoma, and probably stomach cancer. No link was detected between esophageal, thyroid, colorectal cancer or cervical carcinoma, on the one hand, and GMF variations in prenatal period, on the other...
2007: Voprosy Onkologii
keyword
keyword
57472
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"