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https://www.readbyqxmd.com/read/28749599/heat-induced-inflammation-and-its-role-in-esophageal-cancer
#1
REVIEW
Mohaddese Maghsudlu, Ehsan Farashahi Yazd
Esophageal cancer as the sixth common cause of cancer death in the world consists of different histological types with various incidence patterns. Among them, esophageal adenocarcinoma and esophageal squamous cell carcinoma are the most prevalent types which also have different causality, cell of origin and risk factors. Since epidemiological studies have announced consumption of hot substances as one of the major risk factors for squamous cell carcinoma, evaluating the effect of this external stress on esophagus cells seems desirable...
July 27, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28749506/the-origin-of-high-electrocatalytic-activity-of-hydrogen-peroxide-reduction-reaction-by-a-g-c3n4-hopg-sensor
#2
C G Gomez, A M Silva, M C Strumia, L B Avalle, M I Rojas
Graphitic carbon nitride (g-C3N4) was synthesized from a low-cost precursor by means of a thermal process. The product was characterized by several spectroscopic techniques and the crystallinity was analyzed by X-ray diffraction. In the manufacture of the sensor, g-C3N4 was chemically exfoliated and a film was placed on the surface of a Highly Oriented Pyrolytic Graphite (HOPG). We compared the electrocatalytic activities of g-C3N4/HOPG and pristine HOPG surfaces as sensors for H2O2 quantification in buffer solution at pH 7...
July 27, 2017: Nanoscale
https://www.readbyqxmd.com/read/28749505/the-influence-of-surface-area-porous-structure-and-surface-state-on-the-supercapacitor-performance-of-titanium-oxynitride-implications-for-a-nanostructuring-strategy
#3
Eun Joo Lee, Lanlee Lee, Muhammad Awais Abbas, Jin Ho Bang
A recent surge of interest in metal (oxy)nitride materials for energy storage devices has given rise to the rapid development of various nanostructuring strategies for these materials. In supercapacitor applications, early transition metal (oxy)nitrides have been extensively explored, among which titanium oxynitride stands out due to its great potential for charge storage. Despite recent advances in supercapacitors based on titanium oxynitride, many underlying factors governing their capacitive performance remain elusive...
July 27, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28749503/crab-shell-induced-synthesis-of-ordered-macroporous-carbon-nanofiber-arrays-coupled-with-mnco2o4-nanoparticles-as-bifunctional-oxygen-catalysts-for-rechargeable-zn-air-batteries
#4
Duan Bin, Ziyang Guo, Andebet Gedamu Tamirat, Yuanyuan Ma, Yonggang Wang, Yongyao Xia
The oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) are traditionally carried out using noble metals (such as Pt) and metal oxides (such as RuO2 and IrO2) as catalysts, respectively. Nevertheless, several key issues such as high cost, poor stability, and detrimental environmental effects limit the catalytic activity of these noble metal- and metal oxide-based catalysts. Herein, we have designed and synthesized macroporous carbon nanofiber arrays by using a natural crab shell template. Subsequently, spinel MnCo2O4 nanoparticles were embedded into the nitrogen-doped macroporous carbon nanofiber arrays (NMCNAs) by a hydrothermal method...
July 27, 2017: Nanoscale
https://www.readbyqxmd.com/read/28749496/electrodeposited-high-strength-thermally-stable-spectrally-selective-rhenium-nickel-inverse-opals
#5
Runyu Zhang, Joseph Cohen, Shanhui Fan, Paul V Braun
Rhenium-Nickel (RexNi100-x) based 3D metallic inverse opals (IOs) were realized via colloidal crystal templated electrodeposition from an aqueous electrolyte. By varying the electrodeposition parameters, x could be varied from 0 to 88. Under reducing conditions, the rhenium-rich IOs were structurally stable to temperatures of at least 1000 °C for 5 h and for at least 12 h after coating with a thin layer of Al2O3. This demonstrated level of thermal stability is significantly improved compared to previously reported electrodeposited refractory inverse opals with similar characteristic dimensions...
July 27, 2017: Nanoscale
https://www.readbyqxmd.com/read/28749490/evidence-for-cooperative-na-and-cl-binding-by-strongly-hydrated-l-proline
#6
Olga A Dmitrieva, Marina V Fedotova, Richard Buchner
In nature the amino acid l-proline (Pro) is a ubiquitous and highly effective osmolyte protecting cells against osmotic stress. To understand this effect knowledge of the hydration of Pro and its interactions with dissolved salts is essential. We studied these properties by combining statistical mechanics and broadband dielectric spectroscopy and found that Pro remains strongly hydrated up to high amino-acid concentrations. This is also the case upon NaCl addition to a 0.6 M Pro solution. Here, additionally a Pro·NaCl aggregate is formed with a stability constant of K° ≈ 0...
July 27, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28749470/mir-181d-and-c-myc-mediated-inhibition-of-cry2-and-fbxl3-reprograms-metabolism-in-colorectal-cancer
#7
Xiaofeng Guo, Yuekun Zhu, Xinya Hong, Mukun Zhang, Xingfeng Qiu, Zhenfa Wang, Zhongquan Qi, Xuehui Hong
Colorectal cancer (CRC) is the second major cause of tumor-related deaths. MicroRNAs (miRNAs) have pivotal roles in CRC progression. Here, we describe the effect of miR-181d on CRC cell metabolism and underlying molecular mechanism. Our data firmly demonstrated that knockdown of miR-181d suppressed CRC cell proliferation, migration, and invasion by impairing glycolysis. Mechanistically, miR-181d stabilized c-myc through directly targeting the 3'-UTRs of CRY2 and FBXL3, which subsequently increased the glucose consumption and the lactate production...
July 27, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28749427/advanced-growth-factor-delivery-systems-in-wound-management-and-skin-regeneration
#8
REVIEW
Jin Woo Park, Seung Rim Hwang, In-Soo Yoon
Growth factors are endogenous signaling molecules that regulate cellular responses required for wound healing processes such as migration, proliferation, and differentiation. However, exogenous application of growth factors has limited effectiveness in clinical settings due to their low in vivo stability, restricted absorption through skin around wound lesions, elimination by exudation prior to reaching the wound area, and other unwanted side effects. Sophisticated systems to control the spatio-temporal delivery of growth factors are required for the effective and safe use of growth factors as regenerative treatments in clinical practice, such as biomaterial-based drug delivery systems (DDSs)...
July 27, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28749370/hierarchical-nanosheet-based-ni3s2-microspheres-grown-on-ni-foam-for-high-performance-all-solid-state-asymmetric-supercapacitors
#9
Gaofeng Li, Yuan Cong, Chuanxiang Zhang, Haijun Tao, Yueming Sun, Yuqiao Wang
The hierarchical nanosheet-based Ni3S2 microspheres directly grew on Ni foam using a two-step hydrothermal method. The microsphere with a diameter of ~1 microns and a rough surface was well connected with each other without any binders to provide a larger specific surface area, shorter ion/electron diffusion paths, richer electroactive sites as a supercapacitor electrode. As a three-electrode supercapacitor, it delivers the high specific capacity of 981.8 F g-1 at 2 A g-1, excellent rate capability of 436.4 F g-1 at 12 A g-1, and good cycling stability of 950...
July 27, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28749363/distributed-parametric-consensus-optimization-with-an-application-to-model-predictive-consensus-problem
#10
Xinli Shi, Jinde Cao, Wei Huang
In this paper, we study a special class of distributed convex optimization problems--distributed parametric consensus optimization problem (DPCOP), for which a two-stage optimization method including primal decomposition and distributed consensus is provided. Different from traditional distributed optimization problems driving all the local states to a common value, DPCOP aims to solve a system-wide problem with partial common parameters shared amongst local agents in a distributed way. To relax the restriction on the topology, a distributed projected subgradient method is applied in distributed consensus stage to achieve the consensus of local estimated parameters, while the subgradients can be obtained by solving a multiparametric problem locally...
July 25, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28749355/hardware-accelerator-for-the-multifractal-analysis-of-dna-sequences
#11
Jorge E Duarte-Sanchez, Jaime Velasco-Medina, Pedro A Moreno
The multifractal analysis has allowed to quantify the genetic variability and non-linear stability along the human genome sequence. It has some implications in explaining several genetic diseases given by some chromosome abnormalities, among other genetic particularities. The multifractal analysis of a genome is carried out by dividing the complete DNA sequence in smaller fragments and calculating the generalized dimension spectrum of each fragment using the chaos game representation and the box-counting method...
July 24, 2017: IEEE/ACM Transactions on Computational Biology and Bioinformatics
https://www.readbyqxmd.com/read/28749242/interactive-association-between-rhoa-transcriptional-signaling-inhibitor-ccg1423-and-human-serum-albumin-biophysical-and-in-silico-studies
#12
Zahirul Kabir, Hamidah Ghani, Saharuddin B Mohamad, Zazali Alias, Saad Tayyab
Multiple spectroscopic techniques, such as fluorescence, absorption and circular dichroism along with in silico studies were used to characterize the binding of a potent inhibitor molecule, CCG1423 to the major transport protein, human serum albumin (HSA). Fluorescence and absorption spectroscopic results confirmed CCG1423-HSA complex formation. A strong binding affinity stabilized the CCG1423-HSA complex, as evident from the values of the binding constant (Ka = 1.35×10(6) - 5.43×10(5) M(-1)). The KSV values for CCG1423-HSA system were inversely correlated with temperature, suggesting the involvement of static quenching mechanism...
July 27, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28749203/cb002-a-novel-p53-tumor-suppressor-pathway-restoring-small-molecule-induces-tumor-cell-death-through-the-pro-apoptotic-protein-noxa
#13
Liz J Hernandez-Borrero, Shengliang Zhang, Amriti Lulla, David T Dicker, Wafik S El-Deiry
P53 tumor suppressor gene mutations occur in the majority of human cancers and contribute to tumor development, progression and therapy resistance. Direct functional restoration of p53 as a transcription factor has been difficult to achieve in the clinic. We performed a functional screen using a bioluminescence-based transcriptional read-out to identify small molecules that restore the p53 pathway in mutant p53-bearing cancer cells. We identified CB002, as a candidate that restores p53 function in mutant p53-expressing colorectal cancer cells and without toxicity to normal human fibroblasts...
July 27, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28749196/double-stranded-telomeric-dna-binding-proteins-diversity-matters
#14
Filip Červenák, Katarína Juríková, Regina Sepšiová, Martina Neboháčová, Jozef Nosek, Ľubomír Tomáška
Telomeric sequences constitute only a small fraction of the whole genome yet they are crucial for ensuring genomic stability. This function is in large part mediated by protein complexes recruited to telomeric sequences by specific telomere-binding proteins (TBPs). Although the principal tasks of nuclear telomeres are the same in all eukaryotes, TBPs in various taxa exhibit a surprising diversity indicating their distinct evolutionary origin. This diversity is especially pronounced in ascomycetous yeasts where they must have co-evolved with rapidly diversifying sequences of telomeric repeats...
July 27, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28749136/high-performance-pyrochlore-type-yttrium-ruthenate-electrocatalyst-for-oxygen-evolution-reaction-in-acidic-media
#15
Jaemin Kim, Pei-Chieh Shih, Kai-Chieh Tsao, Yung-Tin Pan, Xi Yin, Cheng-Jun Sun, Hong Yang
Development of acid-stable electrocatalysts with low overpotential for oxygen evolution reaction (OER) is a major challenge to produce of hydrogen directly from water. We report in this paper a pyrochlore yttrium ruthenate (Y2Ru2O7-δ) electrocatalyst that has significantly enhanced performance towards OER in acid media over the best-known catalysts, with an onset overpotential of 190 mV and high stability in 0.1-M perchloric acid solution. X-ray absorption near-edge structure (XANES) indicates Y2Ru2O7-δ electrocatalyst had a low valence state that favors the high OER activity...
July 27, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28749130/fluorination-of-boron-doped-diamond-film-electrodes-for-minimization-of-perchlorate-formation
#16
Pralay Gayen, Brian P Chaplin
This research investigated the effects of surface fluorination on both rates of organic compound oxidation (phenol, terephthalic acid (TA)) and ClO4(-) formation at boron-doped diamond (BDD) film anodes at 22(o) C. Different fluorination methods (i.e., electrochemical oxidation with perfluorooctanoic acid (PFOA), radio frequency plasma, and silanization) were used to incorporate fluorinated moieties on the BDD surface, which was confirmed by X-ray photoelectron spectroscopy (XPS). The silanization method was found to be the most effective fluorination method using a 1H, 1H, 2H, 2H perfluorodecyltrichlorosilane (aliphatic silane) precursor to form a self assembled monolayer (SAM) on the oxygenated BDD surface...
July 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28749024/chemical-stability-of-morphine-and-methadone-and-of-methadone-in-combination-with-acepromazine-medetomidine-or-xylazine-during-prolonged-storage-in-syringes
#17
D Y Lee, N Watson, T Whittem
OBJECTIVE: To assess the chemical and physical stability of morphine and methadone stored in syringes for 12 months and of methadone when mixed with acepromazine, medetomidine or xylazine. METHODS: A high-performance liquid chromatography (HPLC) technique was developed and validated for the analysis of morphine and methadone. Morphine and methadone were dispensed into syringes and stored at 25°C/60% relative humidity (RH) and 40°C/75% RH. Solutions containing mixtures of methadone combined with acepromazine, medetomidine or xylazine were stored in syringes at 25°C/60%RH...
August 2017: Australian Veterinary Journal
https://www.readbyqxmd.com/read/28749023/in-this-issue-august-2017-urgent-action-needed-to-facilitate-insecticides-for-screwworm-infestation-%C3%A2-%C3%A2-%C3%A2-experimental-footrot-studies-in-sheep-%C3%A2-%C3%A2-%C3%A2-oestrus-synchronisation-programs-in-dairy-cattle-%C3%A2-%C3%A2-%C3%A2-neuroendodermal-cyst-in-a-dog-%C3%A2-%C3%A2-%C3%A2-stability-of-morphine
#18
EDITORIAL
https://www.readbyqxmd.com/read/28749012/disulfide-bond-mimetics-strategies-and-challenges
#19
Alessandro Gori, Paola Gagni, Silvia Rinaldi
The activity profile of many biologically relevant proteins and peptides often relies on a precise 3D structural organization. In this context, disulfide bonds are natural covalent constraints that play a key role in driving and stabilizing the folding pattern of these molecules. Despite its prominent significance as structural motif, the disulfide bond itself is inherently unstable under physiological conditions, posing a major limit to the use and development of disulfide-rich peptides and proteins as molecular tools and drug lead compounds...
July 27, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28748956/thermally-stable-single-atom-pt-m-al2o3-for-selective-hydrogenation-and-co-oxidation
#20
Zailei Zhang, Yihan Zhu, Hiroyuki Asakura, Bin Zhang, Jiaguang Zhang, Maoxiang Zhou, Yu Han, Tsunehiro Tanaka, Aiqin Wang, Tao Zhang, Ning Yan
Single-atom metal catalysts offer a promising way to utilize precious noble metal elements more effectively, provided that they are catalytically active and sufficiently stable. Herein, we report a synthetic strategy for Pt single-atom catalysts with outstanding stability in several reactions under demanding conditions. The Pt atoms are firmly anchored in the internal surface of mesoporous Al2O3, likely stabilized by coordinatively unsaturated pentahedral Al(3+) centres. The catalyst keeps its structural integrity and excellent performance for the selective hydrogenation of 1,3-butadiene after exposure to a reductive atmosphere at 200 °C for 24 h...
July 27, 2017: Nature Communications
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