keyword
MENU ▼
Read by QxMD icon Read
search

Patient turnaround time

keyword
https://www.readbyqxmd.com/read/29906597/saliva-as-a-diagnostic-specimen-for-testing-respiratory-virus-by-a-point-of-care-molecular-assay-a-diagnostic-validity-study
#1
Kelvin Kw To, Cyril Cy Yip, Cherie Yw Lai, Carlos Kh Wong, Deborah Ty Ho, Polly Kp Pang, Anthony Ck Ng, Kit-Hang Leung, Rosana Ws Poon, Kwok-Hung Chan, Vincent Cc Cheng, Ivan Fn Hung, Kwok-Yung Yuen
OBJECTIVES: Automated point-of-care molecular assays have greatly shortened the turnaround time of respiratory virus testing. One of the major bottlenecks now lies at the step of the specimen collection especially in a busy clinical setting. Saliva is a convenient specimen type which can be provided easily from adult patients. This study assessed the diagnostic validity, specimen collection time, and cost associated with the use of saliva. METHODS: This was a prospective diagnostic validity study comparing the detection rate of respiratory viruses between saliva and nasopharyngeal aspirate (NPA) among adult hospitalized patients using Xpert® Xpress Flu/RSV...
June 12, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29901861/rapid-proteomic-analysis-for-solid-tumors-reveals-lsd1-as-a-drug-target-in-an-end-stage-cancer-patient
#2
Sophia Doll, Maximilian C Kriegmair, Alberto Santos, Michael Wierer, Fabian Coscia, Helen Michele Neil, Stefan Porubsky, Philipp E Geyer, Andreas Mund, Philipp Nuhn, Matthias Mann
Recent advances in mass spectrometry (MS)-based technologies are now set to transform translational cancer proteomics from an idea to a practice. Here, we present a robust proteomic workflow for the analysis of clinically relevant human cancer tissues that allows quantitation of thousands of tumor proteins in several hours of measuring time and a total turnaround of a few days. We applied it to a chemorefractory metastatic case of the extremely rare urachal carcinoma. Quantitative comparison of lung metastases and surrounding tissue revealed several significantly upregulated proteins, among them lysine-specific histone demethylase 1 (LSD1/KDM1A)...
June 14, 2018: Molecular Oncology
https://www.readbyqxmd.com/read/29889862/viral-load-testing-and-the-use-of-test-results-for-clinical-decision-making-for-hiv-treatment-in-cameroon-an-insight-into-the-clinic-laboratory-interface
#3
George Awungafac, Elvis T Amin, Akemfua Fualefac, Noah F Takah, Lucy A Agyingi, Julius Nwobegahay, Pascale Ondoa, Patrick A Njukeng
BACKGROUND: The viral load (VL) in patients receiving antiretroviral therapy (ART) is the best predictor of treatment outcome. The anticipated benefits of VL monitoring depend on the actual uptake of VL test results for clinical decisions. The objective of this study was to assess the uptake and utilization of VL test results for clinical decisions on HIV treatment in Cameroon, from 2013 to 2017. METHODS: This was a retrospective cohort analysis of data from files of patients receiving ART at Buea, Limbe, Bamenda and Bafoussam regional hospital HIV treatment centers...
2018: PloS One
https://www.readbyqxmd.com/read/29888625/electron-microscopy-can-still-have-a-role-in-the-diagnosis-of-selected-inborn-errors-of-metabolism
#4
Mana Taweevisit, Paul S Thorner
Many anatomic pathology laboratories no longer have electron microscopy facilities. A retrospective review of autopsies was performed to identify cases of inborn errors of metabolism (IEM) and determine the contribution of electron microscopy in making the diagnosis in those cases. Over a period of 17 years, there were 900 perinatal and pediatric autopsies. There were 7 cases (1%) of IEM, including 4 cases of Pompe disease, 1 case of I-cell disease, 1 case of bile acid synthesis defect, and 1 case of mitochondrial disease (Leigh syndrome)...
January 1, 2018: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/29887235/laboratory-testing-in-primary-care-a-systematic-review-of-health-it-impacts
#5
REVIEW
Éric Maillet, Guy Paré, Leanne M Currie, Louis Raymond, Ana Ortiz de Guinea, Marie-Claude Trudel, Josianne Marsan
INTRODUCTION: Laboratory testing in primary care is a fundamental process that supports patient management and care. Any breakdown in the process may alter clinical information gathering and decision-making activities and can lead to medical errors and potential adverse outcomes for patients. Various information technologies are being used in primary care with the goal to support the process, maximize patient benefits and reduce medical errors. However, the overall impact of health information technologies on laboratory testing processes has not been evaluated...
August 2018: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/29885310/evaluation-of-bd-vacutainer%C3%A2-barricor%C3%A2-blood-collection-tubes-for-routine-chemistry-testing-on-a-roche-cobas%C3%A2-8000-platform
#6
Jeffrey E Fournier, Victoria Northrup, Claudette Clark, Jacqueline Fraser, Michael Howlett, Paul Atkinson, Jennifer L Shea
INTRODUCTION: Barricor™ Vacutainers® are a novel non-gel separator blood collection tube. These tubes enable faster pre-analytical processing which could reduce turnaround time and be beneficial in an acute care setting. We sought to evaluate the bias, stability, and integrity of plasma generated from these tubes compared to Plasma Separator Tubes™ (PST) for 50 routine chemistry analytes on a Roche Cobas® 8000 analyzer. METHODS: Paired samples were collected from 150 patients originating in the emergency department and outpatient collections at the Saint John Regional Hospital...
June 6, 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29848567/direct-whole-genome-sequencing-of-sputum-accurately-identifies-drug-resistant-mycobacterium-tuberculosis-faster-than-mgit-culture-sequencing
#7
Ronan M Doyle, Carrie Burgess, Rachel Williams, Rebecca Gorton, Helen Booth, James Brown, Josephine M Bryant, Jackie Chan, Dean Creer, Jolyon Holdstock, Heinke Kunst, Stefan Lozewicz, Gareth Platt, Erika Yara Romero, Graham Speight, Simon Tiberi, Ibrahim Abubakar, Marc Lipman, Timothy D McHugh, Judith Breuer
The current methods available to diagnose antimicrobial resistant Mycobacterium tuberculosis infections require positive culture or only test a limited number of resistance-associated mutations. Rapid, accurate identification of antimicrobial resistance enables prompt initiation of effective treatment. Here, we determine the utility of whole-genome sequencing (WGS) M. tuberculosis directly from routinely obtained diagnostic sputum samples to provide a comprehensive resistance profile compared to Mycobacterial Growth Indicator Tube (MGIT) WGS...
May 30, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29794541/can-biomarkers-improve-the-rational-use-of-antibiotics
#8
Patricia S Fontela, Shauna O'Donnell, Jesse Papenburg
PURPOSE OF REVIEW: We aim to review recent literature about the use of biomarkers to guide the initiation and duration of antibiotic treatments for suspected bacterial infections. RECENT FINDINGS: Several good quality meta-analyses show that procalcitonin can be safely used to guide antibiotic-related decisions, especially for respiratory infections, thereby decreasing unnecessary antibiotic exposure. Furthermore, the use of CRP-based algorithms to guide antibiotic initiation in primary care patients with acute respiratory infections is associated with a reduction in antibiotic use without an increase in adverse events...
May 21, 2018: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/29790446/ninety-to-nothing-a-pdsa-quality-improvement-project
#9
Gayle Linda Prybutok
Purpose The purpose of this paper is to present a case study of a successful quality improvement project in an acute care hospital focused on reducing the time of the total patient visit in the emergency department. Design/methodology/approach A multidisciplinary quality improvement team, using the PDSA (Plan, Do, Study, Act) Cycle, analyzed the emergency department care delivery process and sequentially made process improvements that contributed to project success. Findings The average turnaround time goal of 90 minutes or less per visit was achieved in four months, and the organization enjoyed significant collateral benefits both internal to the organization and for its customers...
May 14, 2018: International Journal of Health Care Quality Assurance
https://www.readbyqxmd.com/read/29790443/improvement-of-laboratory-turnaround-time-using-lean-methodology
#10
Shradha Gupta, Sahil Kapil, Monica Sharma
Purpose The purpose of this paper is to discuss the implementation of lean methodology to reduce the turnaround time (TAT) of a clinical laboratory in a super speciality hospital. Delays in report delivery lead to delayed diagnosis increased waiting time and decreased customer satisfaction. The reduction in TAT will lead to increased patient satisfaction, quality of care, employee satisfaction and ultimately the hospital's revenue. Design/methodology/approach The generic causes resulting in increasing TAT of clinical laboratories were identified using lean tools and techniques such as value stream mapping (VSM), Gemba, Pareto Analysis and Root Cause Analysis...
May 14, 2018: International Journal of Health Care Quality Assurance
https://www.readbyqxmd.com/read/29787327/establishing-and-evaluating-autoverification-rules-with-intelligent-guidelines-for-arterial-blood-gas-analysis-in-a-clinical-laboratory
#11
Jie Wu, Meichen Pan, Huizhen Ouyang, Zhili Yang, Qiaoxin Zhang, Yingmu Cai
Arterial blood gas (ABG) analysis is important for acutely ill patients and should be performed by qualified laboratorians. The existing manual verifications are tedious, time-consuming, and prone to send wrong reports. Autoverification uses computer-based rules to verify clinical laboratory test results without manual review. To date, no data are available on the use of autoverification for ABG analysis. All autoverification rules were established according to AUTO10-A. Additionally, the rules were established using retrospective patient data, and then validated by actual clinical samples in a "live" environment before go-live...
May 1, 2018: SLAS Technology
https://www.readbyqxmd.com/read/29779958/development-of-an-anti-epo-antibody-detection-kit-based-on-lab-on-a-chip-and-bridging-antibody-technologies
#12
Jin-Gyo Oh, Jihyun Seong, Sunmi Han, Tae-Hwe Heo
Immunogenicity is a major concern in the use of biological drugs. In particular, antibody-mediated pure red cell aplasia (PRCA) is a rare condition that is caused by administration of recombinant erythropoietin. There are numerous assay platforms for detect EPO anti-drug antibody (ADA), and most have appropriate assay sensitivity, but in need of improvement in terms of assay turnaround time and user accessibility. Here, the new method was developed based on lab-on-a-chip technology and bridging ELISA. The FREND™ Cartridge is equipped with a microfluidic lateral flow channel, enabling easy, fast and accurate immunoassays with small sample volumes...
May 17, 2018: Biologicals: Journal of the International Association of Biological Standardization
https://www.readbyqxmd.com/read/29774171/the-effect-of-satellite-laboratory-installation-on-chemotherapy-waiting-time-in-an-oncology-treatment-unit
#13
Abdullah Bany Hamdan, Abdullah Aldakhil, Mushabbab Asiri, Jesusa Tamani, Sherwynn Javison, Sheena Peethambaran, Isamme AlFayyad, Richard Erlandez, Huda AlKarim, Musa AlHarbi
Background Timely treatment is a patient's right. Increasing the efficiency of laboratory testing could potentially improve hospital operations, provide quicker access to health services, and have a positive impact on patient experience. Installation of a satellite laboratory may shorten laboratory turnaround time (TAT) and chemotherapy waiting time. Method The laboratory TAT and chemotherapy waiting time were analyzed and compared before and three years after the establishment of the satellite laboratory. Result The mean laboratory TAT decreased from one hour and 30 minutes at baseline in 2012 to 43, 43, and 37 minutes in 2013, 2014, and 2015, respectively; a reduction rate of 59%...
March 16, 2018: Curēus
https://www.readbyqxmd.com/read/29769074/delay-in-reviewing-test-results-prolongs-hospital-length-of-stay-a-retrospective-cohort-study
#14
Mei-Sing Ong, Farah Magrabi, Enrico Coiera
BACKGROUND: Failure in the timely follow-up of test results has been widely documented, contributing to delayed medical care. Yet, the impact of delay in reviewing test results on hospital length of stay (LOS) has not been studied. We examine the relationship between laboratory tests review time and hospital LOS. METHODS: A retrospective cohort study of inpatients admitted to a metropolitan teaching hospital in Sydney, Australia, between 2011 and 2012 (n = 5804)...
May 16, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29760947/incorporating-epilepsy-genetics-into-clinical-practice-a-360%C3%A2-evaluation
#15
Stephanie Oates, Shan Tang, Richard Rosch, Rosalie Lear, Elaine F Hughes, Ruth E Williams, Line H G Larsen, Qin Hao, Hans Atli Dahl, Rikke S Møller, Deb K Pal
We evaluated a new epilepsy genetic diagnostic and counseling service covering a UK population of 3.5 million. We calculated diagnostic yield, estimated clinical impact, and surveyed referring clinicians and families. We costed alternative investigational pathways for neonatal onset epilepsy. Patients with epilepsy of unknown aetiology onset < 2 years; treatment resistant epilepsy; or familial epilepsy were referred for counseling and testing. We developed NGS panels, performing clinical interpretation with a multidisciplinary team...
2018: NPJ Genomic Medicine
https://www.readbyqxmd.com/read/29756162/retrospective-analysis-of-mepivacaine-prilocaine-and-chloroprocaine-for-low-dose-spinal-anaesthesia-in-outpatient-perianal-procedures
#16
Volker Gebhardt, Kevin Kiefer, Dieter Bussen, Christel Weiss, Marc D Schmittner
PURPOSE: Perianal procedures are carried out in an outpatient setting regularly. The purpose of this retrospective analysis was to investigate the impact of different local anaesthetics (LA) for spinal anaesthesia (SPA) on operating room (OR) efficiency (perioperative process times, turnaround times) and postoperative recovery. This study aims on the determination of the optimal LA for low-dose SPA in the specific setting of a high-volume day-surgery centre. METHODS: Anaesthesia records of all patients undergoing perianal outpatient surgery under saddle-block SPA at the Mannheim University Medical Centre from 2008 until 2017 were analysed...
May 13, 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29755687/clinical-application-of-targeted-next-generation-sequencing-for-colorectal-cancer-patients-a-multicentric-belgian-experience
#17
Nicky D'Haene, Quitterie Fontanges, Nancy De Nève, Oriane Blanchard, Barbara Melendez, Monique Delos, Marie-Françoise Dehou, Calliope Maris, Nathalie Nagy, Emmanuel Rousseau, Josse Vandenhove, André Gilles, Carine De Prez, Laurine Verset, Marie-Paule Van Craynest, Pieter Demetter, Jean-Luc Van Laethem, Isabelle Salmon, Marie Le Mercier
International guidelines made RAS (KRAS and NRAS) status a prerequisite for the use of anti-EGFR agents for metastatic colorectal cancer (CRC) patients. Daily, new data emerges on the theranostic and prognostic role of molecular biomarkers; this is a strong incentive for a validated, sensitive, and broadly available molecular screening test. Next-generation sequencing (NGS) has begun to supplant other technologies for genomic profiling. We report here our 2 years of clinical practice using NGS results to guide therapeutic decisions...
April 17, 2018: Oncotarget
https://www.readbyqxmd.com/read/29747221/flow-cytometry-shows-added-value-in-diagnosing-lymphoma-in-brain-biopsies
#18
Matthijs van der Meulen, Jacoline E C Bromberg, King H Lam, Ruben Dammers, Anton W Langerak, Jeanette K Doorduijn, Johan M Kros, Martin J van den Bent, Vincent H J van der Velden
BACKGROUND: To assess the sensitivity, specificity and turnaround time of flow cytometric analysis on brain biopsies compared to histology plus immunohistochemistry analysis in tumors with clinical suspicion of lymphoma. METHODS: All brain biopsies performed between 2010 and 2015 at our institution and analyzed by both immunohistochemistry and flow cytometry were included in this retrospective study. Immunohistochemistry was considered the gold standard. RESULTS: In a total of 77 biopsies from 71 patients, 49 lymphomas were diagnosed by immunohistochemistry, flow cytometry results were concordant in 71 biopsies (92,2%)...
May 10, 2018: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/29739120/concordance-of-capillary-electrophoresis-and-conventional-gel-electrophoresis-in-two-different-groups-of-patients-with
#19
Suekyeung Kim, Hyung-Seok Yang, Anbok Lee, Sun Young Cho
BACKGROUND: Serum and urinary protein electrophoresis play an important role in the identification of monoclonal gammopathy. Recently, capillary electrophoresis (CE) has been adapted in many clinical laboratories because of several advantages such as short turnaround time, automation, and high reproducibility. However, there have been unsolved concerns for the concordance between conventional gel and automated capillary electrophoresis methods for protein separation in clinical specimens...
March 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29719423/reduction-in-laboratory-turnaround-time-decreases-emergency-room-length-of-stay
#20
Nitin Kaushik, Victor S Khangulov, Matthew O'Hara, Ramy Arnaout
Objective: Laboratory tests are an important contributor to treatment decisions in the emergency department (ED). Rapid turnaround of laboratory tests can optimize ED throughout by reducing the length of stay (LOS) and improving patient outcomes. Despite evidence supporting the effect of shorter turnaround time (TAT) on LOS and outcomes, there is still a lack of large retrospective studies examining these associations. Here, we evaluated the effect of a reduction in laboratory TAT on ED LOS using retrospective analysis of Electronic Health Records (EHR)...
2018: Open Access Emergency Medicine: OAEM
keyword
keyword
57463
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"